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A highly competent synthesis of novel 7‐aryl‐10‐thioxo‐7, 10, 11, 12‐tertahydro‐9H‐benzo [H] pyrimido [4, 5‐b] quinoline‐8‐one derivatives has been reported through a Knoevenagel condensation followed by Michael addition and subsequent cyclization using ethanol:acetic acid (8:2 v/v). The mentioned protocol has advantages like high yields, cleaner reactions, operational simplicity, and environment friendliness. Moreover, these compounds were further screened against the plant pathogenic fungi like Colletotrichum truncatum, Ustilago maydis, Trichosporon, Trichothecium sp., Aspergillus oryze, Aspergillus terreus, and Aspergillus niger by agar well method bioassay. The results were elaborated for minimum inhibitory concentration determination using agar dilution method against fungal strains C. truncatum and U. maydis as well as broth dilution method for bacteria species Gram‐positive Bacillus megaterium and Gram‐negative Proteus vulgaris. Most of the tested compounds showed promising results towards the antimicrobial activity. [ABSTRACT FROM AUTHOR]

A highly competent-diversity oriented synthesis of coumarin core derivatives using a Knoevenagel condensation followed by Michael addition and subsequent cyclization in the presence of (±)-camphor-10-sulfonic acid in a water/ethanol (1:1) solvent system is depicted. Furthermore, easy workup procedures with good yield, rapid reactions with high atom economy, and catalyst recyclability are the fascinating features of the procedure. [ABSTRACT FROM AUTHOR]

Polystyrene-supported sulfonic acid has been found to be an efficient catalyst for the one-pot, three-component synthesis of 2 H-indazolo[2,1- b]phthalazinetriones in greener solvent glycerol. Use of greener solvent glycerol along with a polymer-supported, low toxic, and inexpensive catalyst renders the method eco-friendly. High yields, simple product isolation procedure, and fluorescent and electroluminescent natures of the products are the noteworthy aspects of this protocol. [ABSTRACT FROM AUTHOR]

Abstract: Relatively less toxic and biodegradable ionic liquid [C8dabco]Br has been successfully used for the synthesis of quinoxaline and phthalazinetrione derivatives in an aqueous media. Recyclability of catalyst, high yields, use of environmentally benign aqueous media as solvent, simple product isolation and high atom economy are the noteworthy aspects of the protocols. [Copyright &y& Elsevier]