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2. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses
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Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. 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Inquilla-Castillo, Miguel Angel, Juàrez-Eyzaguirre, Jesus Alberto, Laca-Barrera, Manuel, León-Jiménez, Franco, Luna-Wilson, Carla Vanessa, Màlaga, German, Marin, Ricardo, Mejía-Cordero, Fernando, Mendoza-Laredo, Juan Arturo, Meregildo-Rodríguez, Edinson Dante, Miranda-Manrique, Gonzalo Francisco, Olivera-Chaupis, Marco, Ortega-Monasterios, Fatima Josefina, Otazú-Ybàñez, Jimmy Pedro, Paredes-Moreno, María Angélica, Peña-Mayorga, Claudia Ximena, Peña-Vàsquez, Olivia del Carmen, Peña-Villalobos, Alejandro, Ponce, Oscar J, Ponte-Fernandez, Katherin Estefania, Pro, Jose, Quispe-Nolazco, César Miguel, Ramos-Samanez, Manuel Efrain, Rojas-Murrugarra, Kory Mirtha, Samanez-Pérez, Jorge Mauro, Sànchez-Carrillo, Halbert Chrostian, Sànchez-Garavito, Epifanio, Sànchez-Sevillano, Ricardo Manuel, Sandoval-Manrique, Hernan, Santos-Revilla, Gabriela, Silva-Ramos, Julio Antonio, Solano-Ico, Manuel Alberto, Soto, Alonso, Sotomayor-Woolcott, Giannilu Michelle, Tapia-Orihuela, Ruben Kevin Arnold, Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. Bernadette, Chua, Mitzi Marie, Climacosa, Fresthel Monica, David-Wang, Aileen, De los Reyes, Virginia, Europa, Gilly May, Fernandez, Lenora, Francisco, Jorge, Garcia, Gerard, Garcia, Jemelyn, Gler, Maria Tarcela, Isidro, Marie Grace Dawn, Javier, Rozelle Jade, Kwek, Marion, Lansang, Mary Ann, Lee, Aileen, Li, Kingbherly, Llanes, Mark Ramon Victor, Llorin, Ryan, Macadato, Omar Khayyam, Malundo, Anna Flor, Mercado, Maria Elizabeth, Mujeres, Mercedes, Nepomuceno, Marisse, Ngo-Sanchez, Katha, Orden, Mary Claire, Pablo-Villamor, Maria Philina, Paez, Ruel Dionisio, Palmes, Patricio, Panaligan, Marion, Quinivista-Yoon, Jenny Mae, Ramos, Mary Shiela Ariola, Ramos -Penalosa, Christine, Reyes, Sheila Marie, Roa, Kathryn, Roman, Arthur Dessi, Rosario, Minette Claire, Roxas, Evalyn, Santos, Lourdes Ella Gonzales, Soldevilla, Helmar, Solante, Rontgene, Suaco, Jane, Tagarda, Daisy, Tang, Issa Rufina, Te, Bob, Teo, Dennis, Tibayan, Christopher John, Villalobos, Ralph Elvi, Ymbong, Duane Richard, Zabat, Gelza Mae, Batkova, Stepanka, Cardoso, Orlando, Garrote, Ana-Raquel, Lino, Sara, Manata, Maria-José, Pinheiro, Helder, Póvoas, Diana, Ramirez, Freddy, Seixas, Diana, Naji, Assem, Al Gethamy, M Al, AL-Mulaify, Mohammed Sami, Al Maghraby, Reem, Alrajhi, A, Al Sharidi, Aynaa, Alotaibi, Naif, AlShaharani, F, Barry, Mazin, Ghonem, Leen, Khalel, Anas, Kharaba, Ayman Mohammed, Alabdan, Lulwah, AlAbdullah, Mohammed Sharaf, Al Shabib, Abdullah, Bengu, Simangele, Bennet, Jacklyn, Dubula, Thozama, Howell, Pauline, Janse van Vuuren, Cloete, Kalla, Ismail, Lifson, Aimee, Maasdorp, Shaun, Magua, Nombulelo, Maluleke, Vongani, Mbhele, Nokuphiwa, Mdladla, Nathi, Mendelson, Mark, Menezes, Colin, Mwelase, Thando, Nchabeleng, Maphoshane, Palanee-Phillips, Thesla, Parker, Victoria, Rassool, Mohammed, Reeder, Paul, Sossen, Bianca, Steyn, Dewald, Tsitsi, Merika, van Blydenstein, Sarah Alex, Venter, Michelle, Van Vuuren, Janse, Venturas, Jacquie, Abad Pérez, Daniel, Abenza, Maria José, Alarcón-Payer, Carolina, Armero Garrigos, Eva, Arribas, Jose Ramon, Ascaso, Ana, Berenguer, Juan, Cabello-Clotet, Noemí, Chamorro Tojeiro, Sandra, Cuenca-Acevedo, Rafael, de la Calle, Fernando, Del Toro, Maria Dolores, Díaz Pollàn, Beatriz, Diez, Cristina, Esquillor-Rodrigo, María José, Estrada, Vicente, Fanciulli, Chiara, Fanjul, Francisco, Fernàndez de Orueta, Lucía, Ferre, Adrian, Ferreira Pasos, Eva Maria, Gainzarain-Arana, Juan-Carlos, Garcia, Felipe, García Deltoro, Miguel, Goikoetxea Agirre, Ane Josune, Gómez Barquero, Julia, Gomez-Huelgas, Ricardo, Gonzàlez Moraleja, Julio, Guijarro, Carlos, Gutierrez, Felix, Guzmàn, Jesús, Ibarguren, Maialen, Iribarren, Jose Antonio, Jerusalem, Koen, Juan Arribas, Arturo, Lalueza, A, Leone, Antonio, Lopez Azkarreta, Iñigo, Lozano-Martin, Daniel, Lucendo, Alfredo J, Luengo López, Mariella, Martín Oterino, JA, Masa, JF, Merino, Esperanza, Monge-Maillo, Begoña, Moran-Rodríguez, Miguel-Angel, Muñez Rubio, Elena, Muñoz Sanchez, Josefa, Nuñez Orantos, Maria Jose, Nuño, Enrique, Ortiz-De-Zarate-Ibarra, Zuriñe, Pagàn-Muñoz, Bàrbara, Paño-Pardo, José Ramón, Peñaranda, Maria, Pérez Chica, Gerardo, Pérez Fernàndez, AM, Pérez-López, Carmen, Polo San Ricardo, Victor, Portu-Zapirain, Joseba, Puchades, Francesco, Rivas Paterna, Ana Belen, Rodríguez Vidigal, Francisco F, Rodríguez-Baño, Jesus, Ruiz-Seco, Pilar, Ryan, Pablo, Saez-De-Adana, Ester, Salas, Rosario, Salavert Lletí, Miguel, Sandoval, Raquel, Toyas-Miazza, Carla, Valencia, Jorge, Vargas, Emilio, Velasco, Maria, Von Wichmann, Miguel Angel, Bosshard, Andreas, Calmy, Alexandra, Castro, Tiago, Cavassini, Matthias, Clerc, Olivier, Conen, Anna, Desbaillets, Nicolas, Desgranges, Florian, Duss, Francois, Emonet, Stephane, Erard, Veronique, Eyer, Myriam, Fayet-Mello, Aurélie, Flammer, Yvonne, Friedl, Andrée, Fulchini, Rosamaria, Furrer, Hansjakob, Garin, Nicolas, Gastberger, Salome, Greiner, Michael, Haefliger, David, Haubitz, Sebastian, Hoffmann, Matthias, Isenring, Egon, Jakopp, Barbara, Lampert, Markus, Marinosci, Annalisa, Martin, Yvonne, Petignat, Pierre-Auguste, Piso, Rein Jan, Prendki, Virginie, Rutishauser, Jonas, Schaefer, Elisabeth, Schmiedel, Yvonne, Schwery, Stefan, Stavropoulou, Elisavet, Stoeckle, Marcel, Suttels, Veronique, Thurnher, Maria Christine, van den Bogaart, Lorena, West, Emily, Wiegand, Jan, and Wiggli, Benedikt
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- 2022
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3. COVID-19 vaccination among health care workers in Finland: coverage, perceptions and attitudes
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Hämäläinen, Aleksi, primary, Patovirta, Riitta-Liisa, additional, Vuorinen, Sakari, additional, Leppäaho-Lakka, Jaana, additional, Kilpinen, Sanna, additional, Sieberns, Jennifer, additional, Ruotsalainen, Eija, additional, Koivula, Irma, additional, and Hämäläinen, Sari, additional
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- 2024
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4. Disease burden caused by respiratory syncytial virus compared with influenza among adults: a retrospective cohort study from Eastern Finland in 2017–2018
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Hämäläinen, Aleksi, primary, Savinainen, Ellamaria, additional, Hämäläinen, Sari, additional, Sivenius, Katariina, additional, Kauppinen, Juha, additional, Koivula, Irma, additional, and Patovirta, Riitta-Liisa, additional
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- 2022
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5. Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial
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Nevalainen, Olli P. O., Horstia, Saana, Laakkonen, Sanna, Rutanen, Jarno, Mustonen, Jussi M. J., Kalliala, Ilkka E. J., Ansakorpi, Hanna, Kreivi, Hanna-Riikka, Kuutti, Pauliina, Paajanen, Juuso, Parkkila, Seppo, Paukkeri, Erja-Leena, Perola, Markus, Pourjamal, Negar, Renner, Andreas, Rosberg, Tuomas, Rutanen, Taija, Savolainen, Joni, Ala-Kokko, Tero, Antonen, Jaakko, Delany, Jutta, Ekroos, Heikki, Hankkio, Riina, Haukipää, Mia, Hetemäki, Iivo, Holma, Pia, Holmberg, Ville, Jalkanen, Ville, Jouppila, Jenni, Jämsänen, Toni, Järventie, Juuso, Järvinen, Petrus, Kauma, Heikki, Kilpeläinen, Tuomas P., Komulainen, Riitta, Kuitunen, Ilari, Lamminmäki, Satu M. H., Mattila, Tiina M., Myllärniemi, Marjukka, Mäkinen, Laura K., Mäntylä, Jarkko, Määttä, Gitte, Niskanen, Joni, Nykänen, Taina, Nyqvist, Miro, Partanen, Terhi, Patovirta, Riitta-Liisa, Puusti, Emmi, Reponen, Emma, Risku, Sari, Saalasti, Mari, Salonen, Päivi, Sinisalo, Marjatta U., Sivenius, Katariina, Säilä, Petrus, Tuominen, Susanna, Haukka, Jari K., Guyatt, Gordon H., Tikkinen, Kari A. O., Investigators, Solidarity Finland, Department of Surgery, Faculty of Medicine, Medicum, Clinicum, Department of Obstetrics and Gynecology, HUS Gynecology and Obstetrics, HUS Heart and Lung Center, Department of Medicine, Keuhkosairauksien yksikkö, CAMM - Research Program for Clinical and Molecular Metabolism, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, Porvoo Hospital Area, Hyvinkää Hospital Area, Ville Holmberg's research group / Infections in Migrants, HUS Inflammation Center, Infektiosairauksien yksikkö, HUS Abdominal Center, Urologian yksikkö, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, Faculty Common Matters (Faculty of Medicine), HUS Pharmacy, Jari Haukka / Principal Investigator, Department of Public Health, South Carelia Social and Health care District Eksote, Tampere University, Health Sciences, Tays Research Services, Department of Internal medicine, BioMediTech, and Department of Clinical Microbiology
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Alanine ,Multidisciplinary ,General Physics and Astronomy ,General Chemistry ,3121 Internal medicine ,Antiviral Agents ,General Biochemistry, Genetics and Molecular Biology ,COVID-19 Drug Treatment ,Hospitalization ,Treatment Outcome ,Post-Acute COVID-19 Syndrome ,3121 General medicine, internal medicine and other clinical medicine ,Quality of Life ,Humans ,3111 Biomedicine ,Finland ,Randomized Controlled Trials as Topic - Abstract
We report the first long-term follow-up of a randomized trial (NCT04978259) addressing the effects of remdesivir on recovery (primary outcome) and other patient-important outcomes one year after hospitalization resulting from COVID-19. Of the 208 patients recruited from 11 Finnish hospitals, 198 survived, of whom 181 (92%) completed follow-up. At one year, self-reported recovery occurred in 85% in remdesivir and 86% in standard of care (SoC) (RR 0.94, 95% CI 0.47-1.90). We infer no convincing difference between remdesivir and SoC in quality of life or symptom outcomes (p > 0.05). Of the 21 potential long-COVID symptoms, patients reported moderate/major bother from fatigue (26%), joint pain (22%), and problems with memory (19%) and attention/concentration (18%). In conclusion, after a one-year follow-up of hospitalized patients, one in six reported they had not recovered well from COVID-19. Our results provide no convincing evidence of remdesivir benefit, but wide confidence intervals included possible benefit and harm.
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- 2022
6. Support among healthcare workers for the new mandatory seasonal influenza vaccination policy and its effects on vaccination coverage
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Hämäläinen, Aleksi, primary, Patovirta, Riitta-Liisa, additional, Mauranen, Ella, additional, Hämäläinen, Sari, additional, and Koivula, Irma, additional
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- 2021
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7. Effects of mould remediation on school teachers' health
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Patovirta, Riitta-Liisa, primary, Meklin, Teija, additional, Nevalainen, Aino, additional, and Husman, Tuula, additional
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- 2004
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8. MOULD SPECIFIC IgG ANTIBODIES CONNECTED WITH SINUSITIS IN TEACHERS OF MOULD DAMAGED SCHOOL: A TWO-YEAR FOLLOW-UP STUDY.
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Patovirta, Riitta-Liisa, Reiman, Marjut, Husman, Tuula, Haverinen, Ulla, Toivola, Mika, and Nevalainen, Aino
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MOLDS (Fungi) , *IMMUNOGLOBULIN G , *IMMUNOGLOBULINS , *SINUSITIS , *TEACHERS - Abstract
Objectives:The aim of this study was to describe the relationship between mould exposure induced by moisture damage and mould specific immunoglobulin G antibodies to 20 common mould species and their association with respiratory diseases. Materials and Methods: Mould specific c immunoglobulin G (IgG) antibodies were monitored in teachers in a follow-up after an extensive mould remediation process in school buildings. IgG antibodies to 20 different microbes were determined from the sera of 26 teachers (19 exposed and 7 references) by enzyme-linked immunosorbent assay (ELISA). The serum samples were drawn twice, firstly at the completion of the remediation in the spring of 1997 and secondly, two years later in the spring of 1999. Health data was collected with self-administered questionnaires. Results: No statistical differences were found in the overall concentrations of 20 mould-specific IgG-antibodies between the study and control groups at the beginning of the study. An association between sinusitis and elevated mould-specific IgG-levels for Aspergillus fumigatus, Aspergillus versicolor, Aureobasidium pullulans, Chaetomium globosum, Cladosporium cladosporioides, Phialophora bubakii, Rhodotorula glutinis, Sporobolomyces salmonicolor, Stachybotrys atra, and Tritirachium roseum was found in the study group. Conclusions: In a two-year follow-up the total concentration of the IgG antibodies for Tritoseum was lower at the end than at the beginning of the follow-up and this remained significant for the group of teachers with sinusitis. The decrease in... [ABSTRACT FROM AUTHOR]
- Published
- 2003
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