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4. A randomized controlled trial of antibody response to 2019–20 cell-based inactivated and egg-based live attenuated influenza vaccines in children and young adults

Author

Williams, Katherine V., primary, Zhai, Bo, additional, Alcorn, John F., additional, Patricia Nowalk, Mary, additional, Levine, Min Z., additional, Kim, Sara S., additional, Flannery, Brendan, additional, Moehling Geffel, Krissy, additional, Jaber Merranko, Amanda, additional, Nagg, Jennifer P., additional, Collins, Mark, additional, Susick, Michael, additional, Clarke, Karen S., additional, Zimmerman, Richard K., additional, and Martin, Judith M., additional

Published
2022
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5. 2062. Improving Antibiotic Prescribing in the Ambulatory Care Setting—Stewardship through Influenza Vaccination, US Flu VE Network 2013–2014 Through 2017–2018

Author

Smith, Emily, primary, M. Fry, Alicia, additional, Hicks, Lauri, additional, Fleming-Dutra, Katherine E, additional, Martin, Emily T, additional, Zimmerman, Richard, additional, Jackson, Michael L, additional, McLean, Huong, additional, Olson, Scott C, additional, Gaglani, Manjusha, additional, Flannery, Brendan, additional, Ferdinands, Jill, additional, Patel, Manish, additional, and Patricia Nowalk, Mary, additional

Published
2019
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7. 2014-2015 Influenza Vaccine Effectiveness in the United States by Vaccine Type.

Author

Zimmerman, Richard K., Patricia Nowalk, Mary, Jessie Chung, Jackson, Michael L., Jackson, Lisa A., Petrie, Joshua G., Monto, Arnold S., McLean, Huong Q., Belongia, Edward A., Gaglani, Manjusha, Murthy, Kempapura, Fry, Alicia M., and Flannery, Brendan

Subjects
*VACCINE effectiveness, *INFLUENZA viruses, *AGE groups, *VACCINATION, *REVERSE transcriptase polymerase chain reaction
Abstract

Background. Circulating A/H3N2 influenza viruses drifted significantly after strain selection for the 2014-2015 vaccines. Also in 2014-2015, the Advisory Committee on Immunization Practices recommended preferential use of live attenuated influenza vaccine (LAIV) over inactivated influenza vaccine (IIV) among children aged 2-8 years. Methods. Vaccine effectiveness (VE) across age groups and vaccine types was examined among outpatients with acute respiratory illness at 5 US sites using a test-negative design, that compared the odds of vaccination among reverse transcription polymerase chain reaction-confirmed influenza positives and negatives. Results. Of 9311 enrollees with complete data, 7078 (76%) were influenza negative, 1840 (19.8%) were positive for influenza A (A/H3N2, n = 1817), and 395 (4.2%) were positive for influenza B (B/Yamagata, n = 340). The overall adjusted VE was 19% (95% confidence interval [CI], 10% to 27%) and was statistically significant in all age strata except those aged 18-64 years. The adjusted VE of 6% (95%CI, -5% to 17%) against A/H3N2-associated illness was not statistically significant, unlike VE for influenza B/Yamagata, which was 55% (95%CI, 43% to 65%). Among those aged 2-8 years, VE against A/H3N2 was 15% (95%CI, -16% to 38%) for IIV and -3% (CI, -50% to 29%) for LAIV; VE against B/Yamagata was 40% (95%CI, -20% to 70%) for IIV and 74% (95%CI, 25% to 91%) for LAIV. Conclusions. The 2014-2015 influenza vaccines offered little protection against the predominant influenza A/H3N2 virus but were effective against influenza B. Preferential use of LAIV among young children was not supported. [ABSTRACT FROM AUTHOR]

Published
2016
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9. Interim Estimates of 2013-14 Seasonal Influenza Vaccine Effectiveness - United States, February 2014.

Author

Flannery, Brendan, Thaker, Swathi N., Clippard, Jessie, Monto, Arnold S., Ohmit, Suzanne E., Zimmerman, Richard K., Patricia Nowalk, Mary, Gaglani, Manjusha, Jackson, Michael L., Jackson, Lisa A., Belongia, Edward A., McLean, Huong Q., Berman, LaShondra, Foust, Angie, Sessions, Wendy, Spencer, Sarah, and Fry, Alicia M.

Subjects
INFLUENZA vaccines, SEASONAL influenza, RESEARCH, AGE distribution, COMPARATIVE studies, CONFIDENCE intervals, CLINICAL pathology, EVALUATION of medical care, MEDICAL cooperation, REPORT writing, RESPIRATORY diseases, CONTROL groups, INFLUENZA A virus, H1N1 subtype, DESCRIPTIVE statistics, SYMPTOMS, PREVENTION, VACCINATION, THERAPEUTICS
Abstract

The article presents a report which provides interim estimates on the effectiveness of seasonal influenza vaccines in the U.S. from December 2, 2013 to January 23, 2014. Data from the U.S. Influenza Vaccine Effectiveness (Flu VE) Network are analyzed. The value of seasonal influenza vaccination in the prevention of influenza is highlighted.

Published
2014

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