210 results on '"Patrini, Davide"'
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2. Maintaining safe lung cancer surgery during the COVID-19 pandemic in a global city
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Fraser, Stephanie, Baranowski, Ralitsa, Patrini, Davide, Nandi, Jay, Al-Sahaf, May, Smelt, Jeremy, Hoffman, Ross, Santhirakumaran, Gowthanan, Lee, Michelle, Wali, Anuj, Dickinson, Harvey, Jadoon, Mehmood, Harrison-Phipps, Karen, King, Juliet, Pilling, John, Bille, Andrea, Okiror, Lawrence, Stamenkovic, Sasha, Waller, David, Wilson, Henrietta, Jordan, Simon, Begum, Sofina, Buderi, Silviu, Tan, Carol, Hunt, Ian, Vaughan, Paul, Jenkins, Melanie, Hayward, Martin, Lawrence, David, Beddow, Emma, Anikin, Vladimir, Mani, Aleksander, Finch, Jonathan, Maheswaran, Hendramoorthy, Lim, Eric, Routledge, Tom, Lau, Kelvin, and Harling, Leanne
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- 2021
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3. Surgical Techniques for Chest Wall Diseases
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Scarci, Marco, Bedetti, Benedetta, Bertolaccini, Luca, Patrini, Davide, Schmidt, Joachim, Minervini, Fabrizio, Solli, Piergiorgio, Nistor, Claudiu E., editor, Tsui, Steven, editor, Kırali, Kaan, editor, Ciuche, Adrian, editor, Aresu, Giuseppe, editor, and Kocher, Gregor J., editor
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- 2020
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4. A cohort study of 30 day mortality after NON-EMERGENCY surgery in a COVID-19 cold site
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Abdel-Aziz, Tarek Ezzatt, Allen, Clare, Allen, Sian, Alnajjar, Hussain, Andrich, Daniella, Arumuham, Vimoshan, Aslam, Naaila, Barod, Ravi, Batty, Rosie, Briggs, Timothy, Brockbank, Eleanor, Chand, Manish, Choong, Simon, Christopher, Nim, Collins, Justin, Crosbie, James, Dickinson, Louise, Doufekas, Konstantinos, Feneley, Mark, Greenwell, Tamsin, Grey, Alistair, Hamid, Rizwan, Hines, John, Jenks, Julie, Jeyarajah, Arjun, Jurkovic, Davor, Kelkar, Anand, Kotsopoulos, Ioannis, Kurzawinski, Tomasz, Lawrence, David, Li, Chi-Ying, May, Robert, McCullough, Jonathan, Mitsos, Sofoklis, Moore, Caroline, Mould, Tim, Mundy, Anthony, Nathan, Senthil, Nicolae, Robert, Ockrim, Jeremy, Olaitan, Adeola, Orczyk, Clement, Pakzad, Mahreen, Panagiotopoulos, Nikolaos, Patki, Prasad, Patrini, Davide, Pendse, Douglas, Phadnis, Saurabh, Rajan, Prabhakar, Ralph, David, Rampling, Tommy, Sangster, Pippa, Shaw, Greg, Smith, Daron, Sooriakumaran, Prasanna, Sridhar, Ashwin, Strange, Tom, Tran, Maxine, Volanis, Dimitrios, Wood, Dan, Wood, Christopher, Kasivisvanathan, Veeru, Lindsay, Jamie, Rakshani-Moghadam, Sara, Elhamshary, Ahmed, Kapriniotis, Konstantinos, Kazantzis, Georgios, Syed, Bilal, Bex, Axel, Ho, Daniel Heffernan, Hayward, Martin, Bhan, Chetan, MacDonald, Nicola, Clarke, Simon, Walker, David, Bellingan, Geoff, Moore, James, Rohn, Jennifer, Muneer, Asif, Roberts, Lois, Haddad, Fares, and Kelly, John D.
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- 2020
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5. Focus on the pulmonary involvement and genetic patterns in Birt-Hogg-Dubè syndrome: Literature review
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Marziali, Valentina, Geropoulos, Georgios, Frasca, Luca, Longo, Filippo, Patrini, Davide, Panagiotopoulos, Nikolaos, and Crucitti, Pierfilippo
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- 2020
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6. Left VATS Upper Lobectomy
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Scarci, Marco, Bedetti, Benedetta, Bertolaccini, Luca, Righi, Ilaria, Patrini, Davide, Crisci, Roberto, Gonzalez-Rivas, Diego, editor, Ng, Calvin Sze Hang, editor, Rocco, Gaetano, editor, and D’Amico, Thomas A., editor
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- 2019
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7. Reply to Treassure et al.
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Gkikas, Andreas, primary, Kakos, Christos, additional, Lampridis, Savvas, additional, and Patrini, Davide, additional
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- 2023
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8. Editorial: Early chest drain removal following lung resection
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Scarci, Marco, primary, Gkikas, Andreas, additional, Patrini, Davide, additional, Minervini, Fabrizio, additional, and Cerfolio, Robert J., additional
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- 2023
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9. Body composition and lung cancer-associated cachexia in TRACERx
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Al-Sawaf, Othman, Weiss, Jakob, Skrzypski, Marcin, Lam, Jie Min, Karasaki, Takahiro, Zambrana, Francisco, Kidd, Andrew C, Frankell, Alexander M, Watkins, Thomas BK, Martinez-Ruiz, Carlos, Puttick, Clare, Black, James RM, Huebner, Ariana, Al Bakir, Maise, Sokac, Mateo, Collins, Susie, Veeriah, Selvaraju, Magno, Neil, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Ward, Sophia, Jayanth, Nick, Salgado, Roberto, Bridge, Christopher P, Christiani, David C, Mak, Raymond H, Bay, Camden, Rosenthal, Michael, Sattar, Naveed, Welsh, Paul, Liu, Ying, Perrimon, Norbert, Popuri, Karteek, Beg, Mirza Faisal, McGranahan, Nicholas, Hackshaw, Allan, Breen, Danna M, O'Rahilly, Stephen, Birkbak, Nicolai J, Aerts, Hugo JWL, Jamal-Hanjani, Mariam, Swanton, Charles, Lester, Jason F, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Fennell, Dean A, Matharu, Gurdeep, Shaw, Jacqui A, Riley, Joan, Primrose, Lindsay, Boleti, Ekaterini, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Price, Gillian, Kerr, Keith M, Benafif, Sarah, Gilbert, Kayleigh, Naidu, Babu, Patel, Akshay J, Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Middleton, Gary, Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Crosbie, Philip, Gomes, Fabio, Brown, Kate, Carter, Mathew, Chaturvedi, Anshuman, Priest, Lynsey, Oliveira, Pedro, Lindsay, Colin R, Blackhall, Fiona H, Krebs, Matthew G, Summers, Yvonne, Clipson, Alexandra, Tugwood, Jonathan, Kerr, Alastair, Rothwell, Dominic G, Kilgour, Elaine, Dive, Caroline, Schwarz, Roland F, Kaufmann, Tom L, Wilson, Gareth A, Rosenthal, Rachel, Van Loo, Peter, Szallasi, Zoltan, Kisistok, Judit, Diossy, Miklos, Demeulemeester, Jonas, Bunkum, Abigail, Stewart, Aengus, Magness, Alastair, Rowan, Andrew, Karamani, Angeliki, Chain, Benny, Campbell, Brittany B, Castignani, Carla, Bailey, Chris, Abbosh, Christopher, Weeden, Clare E, Lee, Claudia, Richard, Corentin, Hiley, Crispin T, Moore, David A, Pearce, David R, Karagianni, Despoina, Biswas, Dhruva, Levi, Dina, Hoxha, Elena, Cadieux, Elizabeth Larose, Lim, Emilia L, Colliver, Emma, Nye, Emma, Gronroos, Eva, Galvez-Cancino, Felip, Athanasopoulou, Foteini, Gimeno-Valiente, Francisco, Kassiotis, George, Stavrou, Georgia, Mastrokalos, Gerasimos, Zhai, Haoran, Lowe, Helen L, Matos, Ignacio Garcia, Goldman, Jacki, Reading, James L, Herrero, Javier, Rane, Jayant K, Nicod, Jerome, Hartley, John A, Peggs, Karl S, Enfield, Katey SS, Selvaraju, Kayalvizhi, Thol, Kerstin, Litchfield, Kevin, Ng, Kevin W, Chen, Kezhong, Dijkstra, Krijn, Grigoriadis, Kristiana, Thakkar, Krupa, Ensell, Leah, Shah, Mansi, Duran, Marcos Vasquez, Litovchenko, Maria, Sunderland, Mariana Werner, Hill, Mark S, Dietzen, Michelle, Leung, Michelle, Escudero, Mickael, Angelova, Mihaela, Tanic, Miljana, Sivakumar, Monica, Kanu, Nnennaya, Chervova, Olga, Lucas, Olivia, Pich, Oriol, Hobson, Philip, Pawlik, Piotr, Stone, Richard Kevin, Bentham, Robert, Hynds, Robert E, Vendramin, Roberto, Saghafinia, Sadegh, Lopez, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Quezada, Sergio A, Vanloo, Sharon, Zaccaria, Simone, Hessey, Sonya, Boeing, Stefan, Beck, Stephan, Bola, Supreet Kaur, Denner, Tamara, Marafioti, Teresa, Mourikis, Thanos P, Spanswick, Victoria, Barbe, Vittorio, Lu, Wei-Ting, Hill, William, Liu, Wing Kin, Wu, Yin, Naito, Yutaka, Ramsden, Zoe, Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Fraioli, Francesco, Ashford, Paul, Clark, Tristan, Forster, Martin D, Lee, Siow Ming, Borg, Elaine, Falzon, Mary, Papadatos-Pastos, Dionysis, Wilson, James, Ahmad, Tanya, Procter, Alexander James, Ahmed, Asia, Taylor, Magali N, Nair, Arjun, Lawrence, David, Patrini, Davide, Navani, Neal, Thakrar, Ricky M, Janes, Sam M, Hoogenboom, Emilie Martinoni, Monk, Fleur, Holding, James W, Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Khiroya, Reena, Stephens, Robert CM, Wong, Yien Ning Sophia, Bandula, Steve, Sharp, Abigail, Smith, Sean, Gower, Nicole, Dhanda, Harjot Kaur, Chan, Kitty, Pilotti, Camilla, Leslie, Rachel, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Yuan, Yinyin, Chuter, David, MacKenzie, Mairead, Chee, Serena, Alzetani, Aiman, Cave, Judith, Scarlett, Lydia, Richards, Jennifer, Ingram, Papawadee, Austin, Silvia, Lim, Eric, De Sousa, Paulo, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Bhayani, Harshil, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Begum, Sofina, Buderi, Silviu, Kaniu, Daniel, Malima, Mpho, Booth, Sarah, Nicholson, Andrew G, Fernandes, Nadia, Shah, Pratibha, Proli, Chiara, Hewish, Madeleine, Danson, Sarah, Shackcloth, Michael J, Robinson, Lily, Russell, Peter, Blyth, Kevin G, Dick, Craig, Le Quesne, John, Kirk, Alan, Asif, Mo, Bilancia, Rocco, Kostoulas, Nikos, and Thomas, Mathew
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Male ,Proteomics ,Cachexia ,Lung Neoplasms ,Antigens, Neoplasm ,Carcinoma, Non-Small-Cell Lung ,Body Weight ,Body Composition ,Humans ,Neoplasm Recurrence, Local ,Muscle, Skeletal ,Neoplasm Proteins - Abstract
Cancer-associated cachexia (CAC) is a major contributor to morbidity and mortality in individuals with non-small cell lung cancer. Key features of CAC include alterations in body composition and body weight. Here, we explore the association between body composition and body weight with survival and delineate potential biological processes and mediators that contribute to the development of CAC. Computed tomography-based body composition analysis of 651 individuals in the TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy (Rx)) study suggested that individuals in the bottom 20th percentile of the distribution of skeletal muscle or adipose tissue area at the time of lung cancer diagnosis, had significantly shorter lung cancer-specific survival and overall survival. This finding was validated in 420 individuals in the independent Boston Lung Cancer Study. Individuals classified as having developed CAC according to one or more features at relapse encompassing loss of adipose or muscle tissue, or body mass index-adjusted weight loss were found to have distinct tumor genomic and transcriptomic profiles compared with individuals who did not develop such features. Primary non-small cell lung cancers from individuals who developed CAC were characterized by enrichment of inflammatory signaling and epithelial-mesenchymal transitional pathways, and differentially expressed genes upregulated in these tumors included cancer-testis antigen MAGEA6 and matrix metalloproteinases, such as ADAMTS3. In an exploratory proteomic analysis of circulating putative mediators of cachexia performed in a subset of 110 individuals from TRACERx, a significant association between circulating GDF15 and loss of body weight, skeletal muscle and adipose tissue was identified at relapse, supporting the potential therapeutic relevance of targeting GDF15 in the management of CAC. ispartof: NATURE MEDICINE vol:29 issue:4 ispartof: location:United States status: Published online
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- 2023
10. The evolution of non-small cell lung cancer metastases in TRACERx
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Al Bakir, Maise, Huebner, Ariana, Martinez-Ruiz, Carlos, Grigoriadis, Kristiana, Watkins, Thomas BK, Pich, Oriol, Moore, David A, Veeriah, Selvaraju, Ward, Sophia, Laycock, Joanne, Johnson, Diana, Rowan, Andrew, Razaq, Maryam, Akther, Mita, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Hessey, Sonya, Dietzen, Michelle, Colliver, Emma, Frankell, Alexander, Bunkum, Abigail, Lim, Emilia L, Karasaki, Takahiro, Abbosh, Christopher, Hiley, Crispin T, Hill, Mark S, Cook, Daniel E, Wilson, Gareth A, Salgado, Roberto, Nye, Emma, Stone, Richard Kevin, Fennell, Dean A, Price, Gillian, Kerr, Keith M, Naidu, Babu, Middleton, Gary, Summers, Yvonne, Lindsay, Colin R, Blackhall, Fiona H, Cave, Judith, Blyth, Kevin G, Nair, Arjun, Ahmed, Asia, Taylor, Magali N, Procter, Alexander James, Falzon, Mary, Lawrence, David, Navani, Neal, Thakrar, Ricky M, Janes, Sam M, Papadatos-Pastos, Dionysis, Forster, Martin D, Lee, Siow Ming, Ahmad, Tanya, Quezada, Sergio, Peggs, Karl S, Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Birkbak, Nicolai J, Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles, Lester, Jason F, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Matharu, Gurdeep, Shaw, Jacqui A, Riley, Joan, Primrose, Lindsay, Boleti, Ekaterini, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Benafif, Sarah, Gilbert, Kayleigh, Patel, Akshay J, Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Crosbie, Philip, Gomes, Fabio, Brown, Kate, Carter, Mathew, Chaturvedi, Anshuman, Priest, Lynsey, Oliveira, Pedro, Krebs, Matthew G, Clipson, Alexandra, Tugwood, Jonathan, Kerr, Alastair, Rothwell, Dominic G, Kilgour, Elaine, Aerts, Hugo JWL, Schwarz, Roland F, Kaufmann, Tom L, Rosenthal, Rachel, Szallasi, Zoltan, Kisistok, Judit, Sokac, Mateo, Diossy, Miklos, Demeulemeester, Jonas, Stewart, Aengus, Magness, Alastair, Karamani, Angeliki, Chain, Benny, Campbell, Brittany B, Castignani, Carla, Bailey, Chris, Puttick, Clare, Weeden, Clare E, Lee, Claudia, Richard, Corentin, Pearce, David R, Karagianni, Despoina, Biswas, Dhruva, Levi, Dina, Hoxha, Elena, Larose Cadieux, Elizabeth, Gronroos, Eva, Galvez-Cancino, Felip, Athanasopoulou, Foteini, Gimeno-Valiente, Francisco, Kassiotis, George, Stavrou, Georgia, Mastrokalos, Gerasimos, Zhai, Haoran, Lowe, Helen L, Matos, Ignacio, Goldman, Jacki, Reading, James L, Black, James RM, Herrero, Javier, Rane, Jayant K, Nicod, Jerome, Lam, Jie Min, Hartley, John A, Enfield, Katey SS, Selvaraju, Kayalvizhi, Thol, Kerstin, Litchfield, Kevin, Ng, Kevin W, Chen, Kezhong, Dijkstra, Krijn, Thakkar, Krupa, Ensell, Leah, Shah, Mansi, Vasquez, Marcos, Litovchenko, Maria, Werner Sunderland, Mariana, Leung, Michelle, Escudero, Mickael, Angelova, Mihaela, Tanic, Miljana, Sivakumar, Monica, Kanu, Nnennaya, Chervova, Olga, Lucas, Olivia, Al-Sawaf, Othman, Hobson, Philip, Pawlik, Piotr, Bentham, Robert, Hynds, Robert E, Vendramin, Roberto, Saghafinia, Sadegh, Lopez, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Vanloo, Sharon, Boeing, Stefan, Beck, Stephan, Bola, Supreet Kaur, Denner, Tamara, Marafioti, Teresa, Mourikis, Thanos P, Spanswick, Victoria, Barbe, Vittorio, Lu, Wei-Ting, Hill, William, Liu, Wing Kin, Wu, Yin, Naito, Yutaka, Ramsden, Zoe, Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Fraioli, Francesco, Ashford, Paul, Clark, Tristan, Borg, Elaine, Wilson, James, Patrini, Davide, Martinoni Hoogenboom, Emilie, Monk, Fleur, Holding, James W, Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Khiroya, Reena, Stephens, Robert CM, Wong, Yien Ning Sophia, Bandula, Steve, Sharp, Abigail, Smith, Sean, Gower, Nicole, Dhanda, Harjot Kaur, Chan, Kitty, Pilotti, Camilla, Leslie, Rachel, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Yuan, Yinyin, Chuter, David, MacKenzie, Mairead, Chee, Serena, Alzetani, Aiman, Scarlett, Lydia, Richards, Jennifer, Ingram, Papawadee, Austin, Silvia, Lim, Eric, De Sousa, Paulo, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Bhayani, Harshil, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Begum, Sofina, Buderi, Silviu, Kaniu, Daniel, Malima, Mpho, Booth, Sarah, Nicholson, Andrew G, Fernandes, Nadia, Shah, Pratibha, Proli, Chiara, Hewish, Madeleine, Danson, Sarah, Shackcloth, Michael J, Robinson, Lily, Russell, Peter, Dick, Craig, Le Quesne, John, Kirk, Alan, Asif, Mo, Bilancia, Rocco, Kostoulas, Nikos, and Thomas, Mathew
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Clonal Evolution ,Cohort Studies ,Evolution, Molecular ,Lung Neoplasms ,Carcinoma, Non-Small-Cell Lung ,Disease Progression ,Humans ,Neoplasm Metastasis ,Neoplasm Recurrence, Local ,Clone Cells - Abstract
Metastatic disease is responsible for the majority of cancer-related deaths1. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive primary tumour sampling. Polyclonal dissemination, which was associated with extrathoracic disease recurrence, was found in 32% of cases. Primary lymph node disease contributed to metastatic relapse in less than 20% of cases, representing a hallmark of metastatic potential rather than a route to subsequent recurrences/disease progression. Metastasis-seeding subclones exhibited subclonal expansions within primary tumours, probably reflecting positive selection. Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need to develop strategies to target metastasis-seeding subclones before relapse. ispartof: NATURE vol:616 issue:7957 ispartof: location:England status: Published online
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- 2023
11. The evolution of lung cancer and impact of subclonal selection in TRACERx
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Frankell, Alexander M, Dietzen, Michelle, Al Bakir, Maise, Lim, Emilia L, Karasaki, Takahiro, Ward, Sophia, Veeriah, Selvaraju, Colliver, Emma, Huebner, Ariana, Bunkum, Abigail, Hill, Mark S, Grigoriadis, Kristiana, Moore, David A, Black, James RM, Liu, Wing Kin, Thol, Kerstin, Pich, Oriol, Watkins, Thomas BK, Naceur-Lombardelli, Cristina, Cook, Daniel E, Salgado, Roberto, Wilson, Gareth A, Bailey, Chris, Angelova, Mihaela, Bentham, Robert, Martinez-Ruiz, Carlos, Abbosh, Christopher, Nicholson, Andrew G, Le Quesne, John, Biswas, Dhruva, Rosenthal, Rachel, Puttick, Clare, Hessey, Sonya, Lee, Claudia, Prymas, Paulina, Toncheva, Antonia, Smith, Jon, Xing, Wei, Nicod, Jerome, Price, Gillian, Kerr, Keith M, Naidu, Babu, Middleton, Gary, Blyth, Kevin G, Fennell, Dean A, Forster, Martin D, Lee, Siow Ming, Falzon, Mary, Hewish, Madeleine, Shackcloth, Michael J, Lim, Eric, Benafif, Sarah, Russell, Peter, Boleti, Ekaterini, Krebs, Matthew G, Lester, Jason F, Papadatos-Pastos, Dionysis, Ahmad, Tanya, Thakrar, Ricky M, Lawrence, David, Navani, Neal, Janes, Sam M, Dive, Caroline, Blackhall, Fiona H, Summers, Yvonne, Cave, Judith, Marafioti, Teresa, Herrero, Javier, Quezada, Sergio A, Peggs, Karl S, Schwarz, Roland F, Van Loo, Peter, Miedema, Daniel M, Birkbak, Nicolai J, Hiley, Crispin T, Hackshaw, Allan, Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Matharu, Gurdeep, Shaw, Jacqui A, Riley, Joa, Primrose, Lindsay, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Gilbert, Kayleigh, Patel, Akshay J, Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Crosbie, Philip, Gomes, Fabio, Brown, Kate, Carter, Mathew, Chaturvedi, Anshuman, Priest, Lynsey, Oliveira, Pedro, Lindsay, Colin R, Clipson, Alexandra, Tugwood, Jonathan, Kerr, Alastair, Rothwell, Dominic G, Kilgour, Elaine, Aerts, Hugo JWL, Kaufmann, Tom L, Szallasi, Zoltan, Kisistok, Judit, Sokac, Mateo, Diossy, Miklos, Demeulemeester, Jonas, Stewart, Aengus, Magness, Alastair, Rowan, Andrew, Karamani, Angeliki, Chain, Benny, Campbell, Brittany B, Castignani, Carla, Weeden, Clare E, Richard, Corentin, Pearce, David R, Karagianni, Despoina, Levi, Dina, Hoxha, Elena, Larose Cadieux, Elizabeth, Nye, Emma, Gronroos, Eva, Galvez-Cancino, Felip, Athanasopoulou, Foteini, Gimeno-Valiente, Francisco, Kassiotis, George, Stavrou, Georgia, Mastrokalos, Gerasimos, Zhai, Haoran L, Lowe, Helen L, Matos, Ignacio, Goldman, Jacki, Reading, James L, Rane, Jayant K, Lam, Jie Min, Hartley, John A, Enfield, Katey SS, Selvaraju, Kayalvizhi, Litchfield, Kevin, Ng, Kevin W, Chen, Kezhong, Dijkstra, Krijn, Thakkar, Krupa, Ensell, Leah, Shah, Mansi, Vasquez, Marcos, Litovchenko, Maria, Werner Sunderland, Mariana, Leung, Michelle, Escudero, Mickael, Tanic, Miljana, Sivakumar, Monica, Kanu, Nnennaya, Chervova, Olga, Lucas, Olivia, Al-Sawaf, Othman, Hobson, Philip, Pawlik, Piotr, Stone, Richard Kevin, Hynds, Robert E, Vendramin, Roberto, Saghafinia, Sadegh, Lopez, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Vanloo, Sharon, Boeing, Stefan, Beck, Stephan, Bola, Supreet Kaur, Denner, Tamara, Mourikis, Thanos P, Spanswick, Victoria, Barbe, Vittorio, Lu, Wei-Ting, Hill, William, Wu, Yin, Naito, Yutaka, Ramsden, Zoe, Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Fraioli, Francesco, Ashford, Paul, Clark, Tristan, Borg, Elaine, Wilson, James, Procter, Alexander James, Ahmed, Asia, Taylor, Magali N, Nair, Arjun, Patrini, Davide, Martinoni Hoogenboom, Emilie, Monk, Fleur, Holding, James W, Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Khiroya, Reena, Stephens, Robert CM, Wong, Yien Ning Sophia, Bandula, Steve, Sharp, Abigail, Smith, Sean, Gower, Nicole, Dhanda, Harjot Kaur, Chan, Kitty, Pilotti, Camilla, Leslie, Rachel, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Yuan, Yinyin, Chuter, David, MacKenzie, Mairead, Chee, Serena, Alzetani, Aiman, Scarlett, Lydia, Richards, Jennifer, Ingram, Papawadee, Austin, Silvia, De Sousa, Paulo, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Bhayani, Harshil, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Begum, Sofina, Buderi, Silviu, Kaniu, Daniel, Malima, Mpho, Booth, Sarah, Fernandes, Nadia, Shah, Pratibha, Proli, Chiara, Danson, Sarah, Robinson, Lily, Dick, Craig, Kirk, Alan, Asif, Mo, Bilancia, Rocco, Kostoulas, Nikos, and Thomas, Mathew
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Lung Neoplasms ,Treatment Outcome ,DNA Copy Number Variations ,Mutagenesis ,Carcinoma, Non-Small-Cell Lung ,Mutation ,Smoking ,Humans ,Adenocarcinoma of Lung ,Neoplasm Recurrence, Local ,Phylogeny - Abstract
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome. In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite patients having a history of smoking, 8% of lung adenocarcinomas lacked evidence of tobacco-induced mutagenesis. These tumours also had similar detection rates for EGFR mutations and for RET, ROS1, ALK and MET oncogenic isoforms compared with tumours in never-smokers, which suggests that they have a similar aetiology and pathogenesis. Large subclonal expansions were associated with positive subclonal selection. Patients with tumours harbouring recent subclonal expansions, on the terminus of a phylogenetic branch, had significantly shorter disease-free survival. Subclonal WGD was detected in 19% of tumours, and 10% of tumours harboured multiple subclonal WGDs in parallel. Subclonal, but not truncal, WGD was associated with shorter disease-free survival. Copy number heterogeneity was associated with extrathoracic relapse within 1 year after surgery. These data demonstrate the importance of clonal expansion, WGD and copy number instability in determining the timing and patterns of relapse in non-small cell lung cancer and provide a comprehensive clinical cancer evolutionary data resource. ispartof: NATURE vol:616 issue:7957 ispartof: location:England status: Published online
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- 2023
12. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx
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Karasaki, Takahiro, Moore, David A, Veeriah, Selvaraju, Naceur-Lombardelli, Cristina, Toncheva, Antonia, Magno, Neil, Ward, Sophia, Al Bakir, Maise, Watkins, Thomas BK, Grigoriadis, Kristiana, Huebner, Ariana, Hill, Mark S, Frankell, Alexander M, Abbosh, Christopher, Puttick, Clare, Zhai, Haoran, Gimeno-Valiente, Francisco, Saghafinia, Sadegh, Kanu, Nnennaya, Dietzen, Michelle, Pich, Oriol, Lim, Emilia L, Martinez-Ruiz, Carlos, Black, James RM, Biswas, Dhruva, Campbell, Brittany B, Lee, Claudia, Colliver, Emma, Enfield, Katey SS, Hessey, Sonya, Hiley, Crispin T, Zaccaria, Simone, Litchfield, Kevin, Birkbak, Nicolai J, Cadieux, Elizabeth Larose, Demeulemeester, Jonas, Van Loo, Peter, Adusumilli, Prasad R, Tan, Kay See, Cheema, Waseem, Sanchez-Vega, Francisco, Jones, David R, Rekhtman, Natasha, Travis, William D, Hackshaw, Allan, Marafioti, Teresa, Salgado, Roberto, Le Quesne, John, Nicholson, Andrew G, McGranahan, Nicholas, Swanton, Charles, Jamal-Hanjani, Mariam, Lester, Jason F, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Fennell, Dean A, Matharu, Gurdeep, Shaw, Jacqui A, Riley, Joan, Primrose, Lindsay, Boleti, Ekaterini, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Price, Gillian, Kerr, Keith M, Benafif, Sarah, Gilbert, Kayleigh, Naidu, Babu, Patel, Akshay J, Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Middleton, Gary, Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Crosbie, Philip, Gomes, Fabio, Brown, Kate, Carter, Mathew, Chaturvedi, Anshuman, Priest, Lynsey, Oliveira, Pedro, Lindsay, Colin R, Blackhall, Fiona H, Krebs, Matthew G, Summers, Yvonne, Clipson, Alexandra, Tugwood, Jonathan, Kerr, Alastair, Rothwell, Dominic G, Kilgour, Elaine, Dive, Caroline, Aerts, Hugo JWL, Schwarz, Roland F, Kaufmann, Tom L, Wilson, Gareth A, Rosenthal, Rachel, Szallasi, Zoltan, Kisistok, Judit, Sokac, Mateo, Diossy, Miklos, Bunkum, Abigail, Stewart, Aengus, Magness, Alastair, Rowan, Andrew, Karamani, Angeliki, Chain, Benny, Castignani, Carla, Bailey, Chris, Weeden, Clare E, Richard, Corentin, Pearce, David R, Karagianni, Despoina, Levi, Dina, Hoxha, Elena, Nye, Emma, Gronroos, Eva, Galvez-Cancino, Felip, Athanasopoulou, Foteini, Kassiotis, George, Stavrou, Georgia, Mastrokalos, Gerasimos, Lowe, Helen L, Matos, Ignacio Garcia, Goldman, Jacki, Reading, James L, Herrero, Javier, Rane, Jayant K, Nicod, Jerome, Lam, Jie Min, Hartley, John A, Peggs, Karl S, Selvaraju, Kayalvizhi, Thol, Kerstin, Ng, Kevin W, Chen, Kezhong, Dijkstra, Krijn, Thakkar, Krupa, Ensell, Leah, Shah, Mansi, Duran, Marcos Vasquez, Litovchenko, Maria, Sunderland, Mariana Werner, Leung, Michelle, Escudero, Mickael, Angelova, Mihaela, Tanic, Miljana, Sivakumar, Monica, Chervova, Olga, Lucas, Olivia, Al-Sawaf, Othman, Prymas, Paulina, Hobson, Philip, Pawlik, Piotr, Stone, Richard Kevin, Bentham, Robert, Hynds, Robert E, Vendramin, Roberto, Lopez, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Quezada, Sergio A, Vanloo, Sharon, Boeing, Stefan, Beck, Stephan, Bola, Supreet Kaur, Denner, Tamara, Mourikis, Thanos P, Spanswick, Victoria, Barbe, Vittorio, Lu, Wei-Ting, Hill, William, Liu, Wing Kin, Wu, Yin, Naito, Yutaka, Ramsden, Zoe, Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Fraioli, Francesco, Ashford, Paul, Clark, Tristan, Forster, Martin D, Lee, Siow Ming, Borg, Elaine, Falzon, Mary, Papadatos-Pastos, Dionysis, Wilson, James, Ahmad, Tanya, Procter, Alexander James, Ahmed, Asia, Taylor, Magali N, Nair, Arjun, Lawrence, David, Patrini, Davide, Navani, Neal, Thakrar, Ricky M, Janes, Sam M, Hoogenboom, Emilie Martinoni, Monk, Fleur, Holding, James W, Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Khiroya, Reena, Stephens, Robert CM, Wong, Yien Ning Sophia, Bandula, Steve, Sharp, Abigail, Smith, Sean, Gower, Nicole, Dhanda, Harjot Kaur, Chan, Kitty, Pilotti, Camilla, Leslie, Rachel, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Yuan, Yinyin, Chuter, David, MacKenzie, Mairead, Chee, Serena, Alzetani, Aiman, Cave, Judith, Scarlett, Lydia, Richards, Jennifer, Ingram, Papawadee, Austin, Silvia, Lim, Eric, De Sousa, Paulo, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Bhayani, Harshil, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Begum, Sofina, Buderi, Silviu, Kaniu, Daniel, Malima, Mpho, Booth, Sarah, Fernandes, Nadia, Shah, Pratibha, Proli, Chiara, Hewish, Madeleine, Danson, Sarah, Shackcloth, Michael J, Robinson, Lily, Russell, Peter, Blyth, Kevin G, Dick, Craig, Kirk, Alan, Asif, Mo, Bilancia, Rocco, Kostoulas, Nikos, and Thomas, Mathew
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TRACERx Consortium - Abstract
Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and micropapillary tumors. How morphology reflects tumor evolution and disease progression is poorly understood. Whole-exome sequencing data generated from 805 primary tumor regions and 121 paired metastatic samples across 248 LUADs from the TRACERx 421 cohort, together with RNA-sequencing data from 463 primary tumor regions, were integrated with detailed whole-tumor and regional histopathological analysis. Tumors with predominantly high-grade patterns showed increased chromosomal complexity, with higher burden of loss of heterozygosity and subclonal somatic copy number alterations. Individual regions in predominantly high-grade pattern tumors exhibited higher proliferation and lower clonal diversity, potentially reflecting large recent subclonal expansions. Co-occurrence of truncal loss of chromosomes 3p and 3q was enriched in predominantly low-/mid-grade tumors, while purely undifferentiated solid-pattern tumors had a higher frequency of truncal arm or focal 3q gains and SMARCA4 gene alterations compared with mixed-pattern tumors with a solid component, suggesting distinct evolutionary trajectories. Clonal evolution analysis revealed that tumors tend to evolve toward higher-grade patterns. The presence of micropapillary pattern and 'tumor spread through air spaces' were associated with intrathoracic recurrence, in contrast to the presence of solid/cribriform patterns, necrosis and preoperative circulating tumor DNA detection, which were associated with extra-thoracic recurrence. These data provide insights into the relationship between LUAD morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk. ispartof: NATURE MEDICINE vol:29 issue:4 ispartof: location:United States status: Published online
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- 2023
13. Postoperative care of a 60 year old male with squamous cell carcinoma with severe COPD and no other comorbidities
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Hayward, Martin, additional and Patrini, Davide, additional
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- 2018
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14. Preoperative assessment and fitness for surgery: T2N0M0 left hilar squamous cell carcinoma in a female with severe COPD
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Hayward, Martin, additional and Patrini, Davide, additional
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- 2018
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15. Preoperative prognostic factors for 5-year survival following pulmonary metastasectomy from colorectal cancer: a systematic review and meta-analysis
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Gkikas, Andreas, primary, Kakos, Christos, additional, Lampridis, Savvas, additional, Godolphin, Peter J, additional, and Patrini, Davide, additional
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- 2023
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16. Lymphoepithelioma-Like Carcinoma of the Lung Associated With Epstein-Barr Virus in a Caucasian Patient: A Case Report
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Lampridis, Savvas, primary, Gkikas, Andreas, additional, Pisciella, Maria Chiara, additional, Salvatorelli, Giulia, additional, and Patrini, Davide, additional
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- 2022
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17. How effective is indocyanine green (ICG) in localization of malignant pulmonary nodules? A systematic review and meta-analysis
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Gkikas, Andreas, primary, Lampridis, Savvas, additional, Patrini, Davide, additional, Kestenholz, Peter B., additional, Scarci, Marco, additional, and Minervini, Fabrizio, additional
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- 2022
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18. The Role of Surgery in Patients with COVID-19-Related Thoracic Complications
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Raveglia, Federico, primary, Scarci, Marco, additional, Rimessi, Arianna, additional, Orlandi, Riccardo, additional, Rebora, Paola, additional, Cioffi, Ugo, additional, Guttadauro, Angelo, additional, Ruffini, Enrico, additional, Benvenuti, Mauro, additional, Cardillo, Giuseppe, additional, Patrini, Davide, additional, Vannucci, Fernando, additional, Yusuf, Nasser, additional, Jindal, Pramoj, additional, and Cerfolio, Robert, additional
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- 2022
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19. Stage IIIA non-small cell lung cancer: a contraindication for video-assisted thoracic surgery lobectomy?—a narrative review
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Schnorr, Philipp, primary, Zalepugas, Donatas, additional, Patrini, Davide, additional, Schmidt, Joachim, additional, and Bedetti, Benedetta, additional
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- 2022
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20. Thoracic Outlet Syndrome: Single Center Experience on Robotic Assisted First Rib Resection and Literature Review
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Gkikas, Andreas, primary, Lampridis, Savvas, additional, Patrini, Davide, additional, Kestenholz, Peter B., additional, Azenha, Luis Filipe, additional, Kocher, Gregor Jan, additional, Scarci, Marco, additional, and Minervini, Fabrizio, additional
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- 2022
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21. Colchicine prevents early postoperative pericardial and pleural effusions
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Imazio, Massimo, Brucato, Antonio, Rovere, Maria Elena, Gandino, Anna, Cemin, Roberto, Ferrua, Stefania, Maestroni, Silvia, Zingarelli, Edoardo, Barosi, Alberto, Simon, Caterina, Sansone, Fabrizio, Patrini, Davide, Vitali, Ettore, Belli, Riccardo, Ferrazzi, Paolo, Trinchero, Rita, Spodick, David H., and Adler, Yehuda
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- 2011
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22. Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies
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Minervini, Fabrizio, primary, Boschetti, Laura, additional, Gregor, Michael, additional, Provencio, Mariano, additional, Calvo, Virginia, additional, Kestenholz, Peter B., additional, Lampridis, Savvas, additional, Patrini, Davide, additional, Bertoglio, Pietro, additional, Azenha, L. Filipe, additional, Sergi, Consolato M., additional, and Kocher, Gregor J., additional
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- 2021
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23. Pneumonectomy for lung cancer in the elderly: lessons learned from a multicenter study
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Minervini, Fabrizio, primary, Kocher, Gregor J., additional, Bertoglio, Pietro, additional, Kestenholz, Peter B., additional, Muñoz, Carlos Gálvez, additional, Patrini, Davide, additional, Ceulemans, Laurens J., additional, Begum, Housne, additional, Lutz, Jon, additional, Shojai, Max, additional, Shargall, Yaron, additional, and Scarci, Marco, additional
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- 2021
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24. Histological characteristics of screen-detected lung cancers: should rate of growth influence management?
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Hall, Helen, primary, Davies, Kate, additional, Frazer, Zoe, additional, Pennycuick, Adam, additional, Hynds, Robert, additional, Hughes, Laura, additional, Teague, Jonathan, additional, Malhi, Aman, additional, Nair, Arjun, additional, Monk, Fleur, additional, Moore, David, additional, Hayward, Martin, additional, Lawrence, David, additional, Mitsos, Sofoklis, additional, Panagiotopoulos, Nikolaos, additional, Patrini, Davide, additional, Ricketts, William, additional, Baranowski, Ralitsa, additional, Lau, Kelvin, additional, Stamenkovic, Sasha, additional, Waller, David, additional, Wilson, Henrietta, additional, Casey, Laura, additional, Giaslakiotis, Konstantinos, additional, Sheaff, Michael, additional, Hackshaw, Allan, additional, and Janes, Sam, additional
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- 2021
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25. Riding the Wave: Maintaining Safe Lung Cancer Surgery During the COVID-19 Pandemic in a Global City
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Fraser, Stephanie, primary, Baranowski, Ralitsa, additional, Patrini, Davide, additional, Nandi, Jayanta, additional, Al-Sahaf, May, additional, Smelt, Jeremy, additional, Hoffman, Ross, additional, Santhirakumaran, Gownathan, additional, Wali, Anuj, additional, Lee, Michelle, additional, Dickinson, Harvey, additional, Jadoon, Mehmood, additional, Harrison-Phipps, Karen, additional, King, Juliet, additional, Pilling, John, additional, Bille, Andrea, additional, Okiror, Lawrence, additional, Stamenkovic, Sasha, additional, Waller, David, additional, Wilson, Henrietta, additional, Jordan, Simon, additional, Begum, Sofina, additional, Buderi, Silviu, additional, Tan, Carol, additional, Hunt, Ian, additional, Vaughan, Paul, additional, Jenkins, Melanie, additional, Hayward, Martin, additional, Lawrence, David, additional, Beddow, Emma, additional, Anikin, Vladimir, additional, Mani, Aleksander, additional, Finch, John, additional, Maheswaran, Hendramoorthy, additional, Lim, Eric, additional, Routledge, Tom, additional, Lau, Kelvin, additional, and Harling, Leanne, additional
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- 2021
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26. A cohort study of 30 day mortality after NON-EMERGENCY surgery in a COVID-19 cold site
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Kasivisvanathan, Veeru, primary, Lindsay, Jamie, additional, Rakshani-Moghadam, Sara, additional, Elhamshary, Ahmed, additional, Kapriniotis, Konstantinos, additional, Kazantzis, Georgios, additional, Syed, Bilal, additional, Hines, John, additional, Bex, Axel, additional, Ho, Daniel Heffernan, additional, Hayward, Martin, additional, Bhan, Chetan, additional, MacDonald, Nicola, additional, Clarke, Simon, additional, Walker, David, additional, Bellingan, Geoff, additional, Moore, James, additional, Rohn, Jennifer, additional, Muneer, Asif, additional, Roberts, Lois, additional, Haddad, Fares, additional, Kelly, John D., additional, Abdel-Aziz, Tarek Ezzatt, additional, Allen, Clare, additional, Allen, Sian, additional, Alnajjar, Hussain, additional, Andrich, Daniella, additional, Arumuham, Vimoshan, additional, Aslam, Naaila, additional, Barod, Ravi, additional, Batty, Rosie, additional, Briggs, Timothy, additional, Brockbank, Eleanor, additional, Chand, Manish, additional, Choong, Simon, additional, Christopher, Nim, additional, Collins, Justin, additional, Crosbie, James, additional, Dickinson, Louise, additional, Doufekas, Konstantinos, additional, Feneley, Mark, additional, Greenwell, Tamsin, additional, Grey, Alistair, additional, Hamid, Rizwan, additional, Jenks, Julie, additional, Jeyarajah, Arjun, additional, Jurkovic, Davor, additional, Kelkar, Anand, additional, Kotsopoulos, Ioannis, additional, Kurzawinski, Tomasz, additional, Lawrence, David, additional, Li, Chi-Ying, additional, May, Robert, additional, McCullough, Jonathan, additional, Mitsos, Sofoklis, additional, Moore, Caroline, additional, Mould, Tim, additional, Mundy, Anthony, additional, Nathan, Senthil, additional, Nicolae, Robert, additional, Ockrim, Jeremy, additional, Olaitan, Adeola, additional, Orczyk, Clement, additional, Pakzad, Mahreen, additional, Panagiotopoulos, Nikolaos, additional, Patki, Prasad, additional, Patrini, Davide, additional, Pendse, Douglas, additional, Phadnis, Saurabh, additional, Rajan, Prabhakar, additional, Ralph, David, additional, Rampling, Tommy, additional, Sangster, Pippa, additional, Shaw, Greg, additional, Smith, Daron, additional, Sooriakumaran, Prasanna, additional, Sridhar, Ashwin, additional, Strange, Tom, additional, Tran, Maxine, additional, Volanis, Dimitrios, additional, Wood, Dan, additional, and Wood, Christopher, additional
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- 2020
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27. Video-thoracoscopic left cardiac sympathetic denervation for long-QT syndrome
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Lampridis, Savvas, primary, Antonopoulos, Achilleas, additional, Kakos, Christos, additional, Mitsos, Sofoklis, additional, Patrini, Davide, additional, Lawrence, David R, additional, and Panagiotopoulos, Nikolaos, additional
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- 2020
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28. Hybrid three-stage repair of mega aorta syndrome with the Lupiae technique
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Troisi, Nicola, Bichi, Samuele, Patrini, Davide, Arena, Vincenzo, Setti, Marco, Pitì, Antonino, and Esposito, Giampiero
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- 2013
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29. Sutureless repair for postinfarction cardiac rupture: A simple approach with a tissue-adhering patch
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Raffa, Giuseppe M., Tarelli, Giuseppe, Patrini, Davide, and Settepani, Fabrizio
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- 2013
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30. Left Atrial Roof: An Alternative Minimal Approach for Mitral Valve Surgery
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Esposito, Giampiero, Cappabianca, Giangiuseppe, Bichi, Samuele, Patrini, Davide, and Pellegrino, Pasquale
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- 2012
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31. The role of a multidisciplinary team in chest wall trauma management
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Patrini, Davide, primary, Lawrence, David, additional, Lampridis, Savvas, additional, Minervini, Fabrizio, additional, Giorgi, Lorenzo, additional, Palermo, Roberto, additional, Hayward, Martin, additional, Scarci, Marco, additional, Schmidt, Joachim, additional, and Bedetti, Benedetta, additional
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- 2020
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32. Changes in the quality of life following surgery for hyperhidrosis
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Patrini, Davide, primary, Bujoreanu, Iulia, additional, Lampridis, Savvas, additional, de Campos, José Ribas Milanez, additional, Bedetti, Benedetta, additional, da Fonseca, Hugo Veiga Sampaio, additional, Lawrence, David, additional, Kauffman, Paulo, additional, and Wolosker, Nelson, additional
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- 2020
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33. Learning points in chest wall trauma management
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Patrini, Davide, primary, Lawrence, David, additional, Lampridis, Savvas, additional, Minervini, Fabrizio, additional, Giorgi, Lorenzo, additional, Palermo, Roberto, additional, Hayward, Martin, additional, Scarci, Marco, additional, Schmidt, Joachim, additional, and Bedetti, Benedetta, additional
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- 2020
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34. COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial
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Imazio, Massimo, Trinchero, Rita, Brucato, Antonio, Rovere, Maria Elena, Gandino, Anna, Cemin, Roberto, Ferrua, Stefania, Maestroni, Silvia, Zingarelli, Edoardo, Barosi, Alberto, Simon, Caterina, Sansone, Fabrizio, Patrini, Davide, Vitali, Ettore, Ferrazzi, Paolo, Spodick, David H., and Adler, Yehuda
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- 2010
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35. Starting a uniportal VATS program - The Bonn experience
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Bedetti, Benedetta, primary, Rimessi, Arianna, additional, Schnorr, Philipp, additional, Matsanis, Iris, additional, Zalepugas, Donatas, additional, Scarci, Marco, additional, Bertolaccini, Luca, additional, Patrini, Davide, additional, and Schmidt, Joachim, additional
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- 2019
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36. The Use of Argon Plasma Energy for Thoracoscopic Pulmonary Metastasectomy: An Alternative Surgical Method
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Lampridis, Savvas, Mitsos, Sofoklis, Patrini, Davide, Lawrence, David R, and Panagiotopoulos, Nikolaos
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- 2019
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37. Rationale and design of the COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 trial): A randomized, placebo-controlled, multicenter study on the use of colchicine for the primary prevention of the postpericardiotomy syndrome, postoperative effusions, and postoperative atrial fibrillation
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Imazio, Massimo, Belli, Riccardo, Brucato, Antonio, Ferrazzi, Paolo, Patrini, Davide, Martinelli, Luigi, Polizzi, Vincenzo, Cemin, Roberto, Leggieri, Anna, Caforio, Alida L.P., Finkelstein, Yaron, Hoit, Brian, Maisch, Bernhard, Mayosi, Bongani M., Oh, Jae K., Ristic, Arsen D., Seferovic, Petar, Spodick, David H., and Adler, Yehuda
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- 2013
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38. Video-thoracoscopic left cardiac sympathetic denervation for long-QT syndrome.
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Lampridis, Savvas, Antonopoulos, Achilleas, Kakos, Christos, Mitsos, Sofoklis, Patrini, Davide, Lawrence, David R, and Panagiotopoulos, Nikolaos
- Abstract
Background: Congenital long-QT syndrome represents the most common cardiac channelopathy and manifests as potentially lethal ventricular arrhythmias. Prevention strategies include beta-blockade pharmacotherapy, implantable cardioverter-defibrillators, and left cardiac sympathetic denervation, which can increase the threshold for ventricular fibrillation. Herein, we report our experience with video-assisted thoracoscopic left cardiac sympathetic denervation. Methods: We performed a retrospective review of the electronic medical records of all patients with congenital long-QT syndrome who underwent video-assisted thoracoscopic left cardiac sympathetic denervation at our institution. Results: From September 2009 to May 2016, 6 patients with a mean age of 30.5 years (range 20–47 years) underwent video-assisted thoracoscopic left cardiac sympathetic denervation for medically refractory long-QT syndrome. All patients had an uneventful recovery and were discharged 1–3 days after the operation. At a median follow-up of 14 months (range 12–60 months), 4 patients had no cardiac events while 2 experienced 1 episode of arrhythmic syncope and 1 episode of appropriate implantable cardioverter-defibrillator shock. Following surgery, the mean annual cardiac events in the study cohort decreased from 2.13 to 0.33 (p = 0.004) and the mean corrected QT interval reduced from 560 ms to 491 ms (p = 0.006). Conclusions: Video-assisted thoracoscopic left cardiac sympathetic denervation is a safe and effective therapy in patients with congenital long-QT syndrome who continue to suffer from recurrent life-threatening arrhythmias or frequent implantable cardioverter-defibrillator discharges despite maximum tolerated doses of beta blockers. [ABSTRACT FROM AUTHOR]
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- 2021
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39. Fc effector function contributes to the activity of human anti-CTLA-4 antibodies
- Author
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Arce Vargas, Frederick, Furness, Andrew J.S., Litchfield, Kevin, Joshi, Kroopa, Rosenthal, Rachel, Ghorani, Ehsan, Solomon, Isabelle, Lesko, Marta H., Ruef, Nora, Roddie, Claire, Henry, Jake Y., Spain, Lavinia, Ben Aissa, Assma, Georgiou, Andrew, Wong, Yien Ning Sophia, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Nicol, David, O'Brien, Tim, Mårtensson, Linda, Ljungars, Anne, Teige, Ingrid, Frendéus, Björn, Pule, Martin, Marafioti, Teresa, Gore, Martin, Larkin, James, Turajlic, Samra, Swanton, Charles, Peggs, Karl S., Quezada, Sergio A., Harrington, Kevin, Melcher, Alan, Wotherspoon, Andrew, Francis, Nicholas, Challacombe, Ben, Fernando, Archana, Hazell, Steve, Chandra, Ashish, Pickering, Lisa, Lynch, Joanna, Rudman, Sarah, Chowdhury, Simon, Harrison-Phipps, Karen, Varia, Mary, Horsfield, Catherine, Polson, Alexander, Stamp, Gordon, O'Donnell, Marie, Drake, William, Hill, Peter, Hrouda, David, Mayer, Eric, Olsburgh, Jonathan, Kooiman, Gordon, O'Connor, Kevin, Stewart, Grant, Aitchison, Michael, Tran, Maxine, Fotiadis, Nicos, Verma, Hema, Lopez, Jose, Lester, Jason, Morgan, Fiona, Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Fennell, Dean, Shaw, Jacqui, Le Quesne, John, Nakas, Apostolos, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Riley, Joan, Primrose, Lindsay, Martinson, Luke, Anand, Girija, Khan, Sajid, Nicolson, Marianne, Kerr, Keith, Palmer, Shirley, Remmen, Hardy, Miller, Joy, Buchan, Keith, Chetty, Mahendran, Gomersall, Lesley, Lock, Sara, Naidu, Babu, Langman, Gerald, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Middleton, Gary, Djearaman, Madava, Summers, Yvonne, Califano, Raffaele, Taylor, Paul, Shah, Rajesh, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Novasio, Juliette, Joseph, Leena, Bishop, Paul, Chaturvedi, Anshuman, Marie Quinn, Anne, Doran, Helen, leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Blackhall, Fiona, Rogan, Jane, Smith, Elaine, Dive, Caroline, Brady, Ged, Rothwell, Dominic, Gulati, Sakshi, Chemie, Francesca, Tugwood, Jonathan, Pierce, Jackie, Lawrence, David, Hayward, Martin, Panagiotopoulos, Nikolaos, George, Robert, Patrini, Davide, Falzon, Mary, Borg, Elaine, Khiroya, Reena, Jamal-Hanjani, Mariam, Wilson, Gareth, Juul Birkbak, Nicolai, Watkins, Thomas, McGranahan, Nicholas, Abbosh, Christopher, Horswell, Stuart, Mitter, Richard, Escudero, Mickael, Stewart, Aengus, Rowan, Andrew, Hiley, Crispin, Goldman, Jacki, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Shaw, Penny, Veeriah, Raju, Czyzewska-Khan, Justyna, Johnson, Diana, Laycock, Joanne, Hynds, Robert, Werner Sunderland, Mariana, Reading, James, Novelli, Marco, Oukrif, Dahmane, Janes, Sam, Forster, Martin, Ahmad, Tanya, Ming Lee, Siow, van Loo, Peter, Herrero, Javier, Hartley, John, Kevin Stone, Richard, Denner, Tamara, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Chambers, Tim, Nye, Emma, Ward, Sophie, Elgar, Greg, Al-Bakir, Maise, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Papadatos-Pastos, Dionysis, Scarci, Marco, Gorman, Pat, Lowe, Helen, Ensell, Leah, Moore, David, MacKenzie, Mairead, Wilcox, Maggie, Bell, Harriet, Hackshaw, Allan, Ngai, Yenting, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Tavares Barbosa, Monica, Nicholson, Andrew, Bowman, Alex, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Elena Cufari, Maria, Carlo Ronquillo, John, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Ezhil, Veni, Prakash, Vineet, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, Asante-Siaw, Julius, Russell, Peter, Light, Teresa, Horey, Tracey, Blyth, Kevin, Dick, Craig, and Kirk, Alan
- Abstract
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8+ to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor responses and survival. In patients with advanced melanoma, response to ipilimumab was associated with the CD16a-V158F high affinity polymorphism. Such activity only appeared relevant in the context of inflamed tumors, explaining the modest response rates observed in the clinical setting. Our data suggest that the activity of anti-CTLA-4 in inflamed tumors may be improved through enhancement of FcγR binding, whereas poorly infiltrated tumors will likely require combination approaches.
- Published
- 2018
40. Bleeding control during VATS major lung resection without conversion: safe and feasible?
- Author
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Minervini, Fabrizio, primary, Kestenholz, Peter Bruno, additional, Bertolaccini, Luca, additional, Bedetti, Benedetta, additional, Patrini, Davide, additional, Cassina, Enrico, additional, and Scarci, Marco, additional
- Published
- 2019
- Full Text
- View/download PDF
41. Is systematic lymph node dissection mandatory or is sampling adequate in patients with stage I non-small-cell lung cancer?
- Author
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Mitsos, Sofoklis, primary, Panagiotopoulos, Nikolaos, additional, Patrini, Davide, additional, and George, Robert S, additional
- Published
- 2018
- Full Text
- View/download PDF
42. Focus on specific disease-part 2: the European Society of Thoracic Surgery chest wall database
- Author
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Bedetti, Benedetta, primary, Patrini, Davide, additional, Bertolaccini, Luca, additional, Crisci, Roberto, additional, Solli, Piergiorgio, additional, Schmidt, Joachim, additional, and Scarci, Marco, additional
- Published
- 2018
- Full Text
- View/download PDF
43. Risk-Adjusted Costs Analysis of a Multicenter Video-Assisted Thoracoscopic Lobectomy Activity
- Author
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Bertolaccini, Luca, primary, Crisci, Roberto, additional, Divisi, Duilio, additional, Bedetti, Benedetta, additional, Libretti, Lidia, additional, Patrini, Davide, additional, Minervini, Fabrizio, additional, and Scarci, Marco, additional
- Published
- 2018
- Full Text
- View/download PDF
44. Multicentre Validation of a Prediction Score of Prolonged Air Leak for VATS Lobectomies
- Author
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Bertolaccini, Luca, primary, Bedetti, Benedetta, additional, Patrini, Davide, additional, Shargall, Yaron, additional, Solli, Piergiorgio, additional, Pirondini, Emanuele, additional, Crisci, Roberto, additional, and Scarci, Marco, additional
- Published
- 2018
- Full Text
- View/download PDF
45. 172 - Histological characteristics of screen-detected lung cancers: should rate of growth influence management?
- Author
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Hall, Helen, Davies, Kate, Frazer, Zoe, Pennycuick, Adam, Hynds, Robert, Hughes, Laura, Teague, Jonathan, Malhi, Aman, Nair, Arjun, Monk, Fleur, Moore, David, Hayward, Martin, Lawrence, David, Mitsos, Sofoklis, Panagiotopoulos, Nikolaos, Patrini, Davide, Ricketts, William, Baranowski, Ralitsa, Lau, Kelvin, Stamenkovic, Sasha, Waller, David, Wilson, Henrietta, Casey, Laura, Giaslakiotis, Konstantinos, Sheaff, Michael, Hackshaw, Allan, and Janes, Sam
- Published
- 2021
- Full Text
- View/download PDF
46. Haemorrhagic complication during a simulation of a right video-assisted thoracic surgery (VATS) upper lobectomy
- Author
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Bedetti, Benedetta, primary, Bertolaccini, Luca, additional, Patrini, Davide, additional, Schmidt, Joachim, additional, and Scarci, Marco, additional
- Published
- 2018
- Full Text
- View/download PDF
47. Virtual reality (VR) simulator of a right video-assisted thoracic surgery (VATS) upper lobectomy
- Author
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Bedetti, Benedetta, primary, Bertolaccini, Luca, additional, Patrini, Davide, additional, Schmidt, Joachim, additional, and Scarci, Marco, additional
- Published
- 2018
- Full Text
- View/download PDF
48. Virtual simulation and learning new skills in video-assisted thoracic surgery
- Author
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Bedetti, Benedetta, primary, Bertolaccini, Luca, additional, Patrini, Davide, additional, Schmidt, Joachim, additional, and Scarci, Marco, additional
- Published
- 2018
- Full Text
- View/download PDF
49. Non-intubated awake uniportal VATS: how to start?
- Author
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Minervini, Fabrizio, primary, Bertolaccini, Luca, additional, Patrini, Davide, additional, Bedetti, Benedetta, additional, Libretti, Lidia, additional, and Scarci, Marco, additional
- Published
- 2018
- Full Text
- View/download PDF
50. Pulmonary metastasectomy and laser-assisted resection
- Author
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Panagiotopoulos, Nikolaos, primary, Patrini, Davide, additional, Lawrence, David, additional, Scarci, Marco, additional, and Mitsos, Sofoklis, additional
- Published
- 2018
- Full Text
- View/download PDF
Catalog
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