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Since December 2019, the world has been facing the life-threatening disease, named Coronavirus disease-19 (COVID-19), recognized as a pandemic by the World Health Organization. The response of the Emergency Medicine network, integrating "out-of-hospital" and "hospital" activation, is crucial whenever the health system has to face a medical emergency, being caused by natural or human-derived disasters as well as by a rapidly spreading epidemic outbreak. We here report the Pavia Emergency Medicine network response to the COVID-19 outbreak. The "out-of-hospital" response was analysed in terms of calls, rescues and missions, whereas the "hospital" response was detailed as number of admitted patients and subsequent hospitalisation or discharge. The data in the first 5 weeks of the Covid-19 outbreak (February 21-March 26, 2020) were compared with a reference time window referring to the previous 5 weeks (January 17-February 20, 2020) and with the corresponding historical average data from the previous 5 years (February 21-March 26). Since February 21, 2020, a sudden and sustained increase in the calls to the AREU 112 system was noted (+ 440%). After 5 weeks, the number of calls and missions was still higher as compared to both the reference pre-Covid-19 period (+ 48% and + 10%, respectively) and the historical control (+ 53% and + 22%, respectively). Owing to the overflow from the neighbouring hospitals, which rapidly became overwhelmed and had to temporarily close patient access, the population served by the Pavia system more than doubled (from 547.251 to 1.135.977 inhabitants, + 108%). To minimize the possibility of intra-hospital spreading of the infection, a separate "Emergency Department-Infective Disease" was created, which evaluated 1241 patients with suspected infection (38% of total ED admissions). Out of these 1241 patients, 58.0% (n = 720) were admitted in general wards (n = 629) or intensive care unit (n = 91). To allow this massive number of admissions, the hospital reshaped many general ward Units, which became Covid-19 Units (up to 270 beds) and increased the intensive care unit beds from 32 to 60. In the setting of a long-standing continuing emergency like the present Covid-19 outbreak, the integration, interaction and team work of the "out-of-hospital" and "in-hospital" systems have a pivotal role. The present study reports how the rapid and coordinated reorganization of both might help in facing such a disaster. AREU-112 and the Emergency Department should be ready to finely tune their usual cooperation to respond to a sudden and overwhelming increase in the healthcare needs brought about by a pandemia like the current one. This lesson should shape and reinforce the future.

The outcome of refractory/relapsed (R/R) acute leukemias is still dismal and their treatment represents an unmet clinical need. However, allogeneic transplantation (allo-HSCT) remains the only potentially curative approach in this setting. A prospective study (GANDALF-01, NCT01814488; EUDRACT:2012-004008-37) on transplantation with alternative donors had been run by GITMO using a homogeneous myeloablative conditioning regimen with busulfan, thiotepa and fludarabine while GVHD prophylaxis was stratified by donor type. The study enrolled 101 patients; 90 found an alternative donor and 87 ultimately underwent allo-HSCT. Two-year overall survival of the entire and of the transplant population (primary endpoint) were 19% and 22%, without significant differences according to disease, donor type and disease history (relapsed vs refractory patients). Two-year progression-free survival was 19% and 17% respectively. The cumulative incidences of relapse and non-relapse mortality were 49% and 33% at two years. Acute grade II-IV and chronic GVHD occurred in 23 and 10 patients. Dose intensification with a myeloablative two-alkylating regimen as sole strategy for transplanting R/R acute leukemia does seem neither to improve the outcome nor to control disease relapse. A pre-planned relapse prevention should be included in the transplant strategy in this patient population.

Despite its brief history, Berlin Dada (1918–20) produced a glut of chronicles and memoirs, as if to immortalize its ephemeral insurgency. Its self-appointed chronicler, Richard Huelsenbeck, tried to harness this compulsion to memorialize in the service of Dadaist agitation he hoped would unleash a revolutionary time and redeem the failure of the communist uprisings at the end of World War I. his seditious temporality was based on two incompatible concepts of revolution: a properly political notion aimed at overthrowing an unjust regime and a vitalist discourse aimed at tapping into the circular low of life. he clash of the two modes of revolutionary time is enacted in Hannah Höch's photomontage “Cut with the Kitchen Knife” (1919). he spectral temporality that sustains both is conjured by the Dada Almanac (1920), a literary compendium that doubles as a quirky inquiry into political normativity and an inluential paradigm of Dada's self-legitimation.

We describe clinical characteristics, treatments and outcomes of 44 Caucasian patients with coronavirus disease (COVID-19) at a single hospital in Pavia, Italy, from 21–28 February 2020, at the beginning of the outbreak in Europe. Seventeen patients developed severe disease, two died. After a median of 6 days, 14 patients were discharged from hospital. Predictors of lower odds of discharge were age > 65 years, antiviral treatment and for severe disease, lactate dehydrogenase > 300 mg/dL.

This essay juxtaposes the understanding of Konstruktion developed within German Constructivism to the humanist notion of Bildung that framed debates on the Bildungsroman and the novel at the beginning of the twentieth century. Far from refuting the project of Bildung, Konstruktion actualizes some of its central tenets while grappling with the questions of temporality and futurity that bedeviled the idea of Bildung. After tracing the ways in which Bildung and Konstruktion played out discursively in the early twentieth century, I examine how the two tropes are productively unfolded in One-Way Street (1928), Walter Benjamin's endeavor at grounding and enacting an activist model of literature. At issue is the possibility of grasping literature as a realm for the performative construction of the human outside the historical teleology that rendered Bildung unacceptable.

This essay examines Irmgard Keun's novel Das kunstseidene Madchen (1932) against the backdrop of Weimar-era discourses on the emancipatory potential of vision. While the narrative's thematization of vision has been productively analyzed from the perspective of feminist and film theory, less attention has been paid to its ties to contemporary discourses concerned with retooling a vision enhanced by new technologies like film into an instrument of emancipatory self-fashioning. As the article shows, Keun's novel reflects critically on these discourses by casting its heroine's sentimental journey in terms of an education in vision that leads to acknowledging the distance between the visual as a mode of inscription and the visible as a domain of perception. In so doing the novel delivers a critical commentary on contemporary discourses that located agency in a conquest of the visible attained by manipulating the visual.

The Chatter of the Visible examines the paradoxical narrative features of the photomontage aesthetics of artists associated with Dada, Constructivism, and the New Objectivity. While montage strategies have commonly been associated with the purposeful interruption of and challenge to narrative consistency and continuity, McBride offers an historicized reappraisal of 1920s and 1930s German photomontage work to show that its peculiar mimicry was less a rejection of narrative and more an extension or permutation of it—a means for thinking in narrative textures exceeding constraints imposed by “flat” print media (especially the novel and other literary genres). McBride’s contribution to the conversation around Weimar-era montage is in her situation of the form of the work as a discursive practice in its own right, which affords humans a new way to negotiate temporality, as a particular mode of thinking that productively relates the particular to the universal, or as a culturally specific form of cognition.

When the Anglo-American artists known as "neo-dada" re- discovered the work of Kurt Schwitters in the late 1950s, they thought they had found a model for robust artistic intervention that promised a way out of the strictures of Abstract Expression- ism. Artists like Robert Rauschenberg and Allan Kaprow saw in Schwitters's collages of recycled refuse a model for critiquing the self-perpetuating cycle of consumerism and waste in capitalist societies. However, their interpretation of Schwitters's practices was based on a misreading of sorts, since Schwitters's use of trash in his collages had never been intended as an anti-capitalist critique of social relations in its day. Quite to the contrary. It had originally served to sustain a formalist aesthetics predicated on the autonomy of art from politics. Indeed, Schwitters's flaunted disinterest for politics with regard to Germany's aborted revolu- tion and the turmoil of the early Weimar period had earned him the contempt of militant Dadaists like George Grosz and Richard Huelsenbeck, who curtly denied his request for admission to the

This article examines the discourse on beauty, style, and fashion developed by Viennese architect and essayist Adolf Loos between the 1890s and the 1920s. Contrary to conventional understanding, it argues that Loos's critique of contemporary architectural and fashion styles should not be read as contributing to the discourse of lost authenticity and estranged identity, which is identified with Viennese modernism. Instead, this essay draws on Loos's passionate endorsement of contemporary fashion in order to reconstruct his optimistic vision of modernity, which he saw peopled by individuals whose identity is inscribed on a discursive surface and lacks the depth of metaphysical substance.

The quality control of herbal drugs and their intermediates is essential, especially when they are used as feedstock for medicine development. This study aimed at applying the methodologies established by Brazilian legislation for the development of parameters concerning the characterization and quality control of leaf powder and tincture of Arrabidaea chica (H & B) Verlot. Known as cipó-pau (vinestick), carajeru, pariri, among others, it presents antifungal activity and is used in several diseases such as mycosis and ringworm. The physico-chemical characteristics of the plant drug. The phytochemical screening of the t inc tur e indi cat ed the pr e s enc e of r educ ing sugar s , anthocyanidins , anthocyanins , anthraquinones, steroids, triterpenoids, phenols, flavanonols, flavanols, flavanones, saponins and tannins catechists. HPLC chromatograms showed peaks at 275 nm and 290 nm, with Rt of 8.91 and 13.57 min, whose corresponding spectra showed absorption maxima which is characteristic of flavones and biflavonols -283 nm and 334 nm. Some metabolites found in the phytochemical screening and detected by HPLC may justify the popular use of A. chica as antimicrobial and antifungal medicine., Colegio de Farmacéuticos de la Provincia de Buenos Aires

Summary This paper reports for the first time data on the taxonomic distribution and abundance of woody plants with extrafloral nectaries (EFNs) in plant communities occuring in the Amazon region, Brazil. Surveys were carried out in four vegetation types: ‘terra firme’ forest, successional forest, ‘buritirana’ (palm vegetation) and ‘shrub canga’ (savanna). EFNSs were present in 30 plant species belonging to 22 genera and 14 families. Nectary species represented 17.6 to 53.3% of the species sampled in different areas, with local abundances varying from 19.1 to 50.0%. The percentage of species with EFNs was greater in the flora of the shrub canga than in the terra firme and successional forests. Nectary plants were more abundant in the shrub canga and successional forest. The data for proportion and abundance of nectary species in Amazonian vegetation types were in general much higher than those obtained in temperate habitats, and support the hypothesis that EFNs tend to be more common in tropical environments. It is suggested that the high abundance of EFNs in the surveyed areas may be the result of intense foraging activity by ants on plants, leading to the formation of facultative mutualisms.