Search

Your search keyword '"Patruno, Leonardo"' showing total 10 results
Start Over Author "Patruno, Leonardo"
10 results on '"Patruno, Leonardo"'

2. Role of Breast Cancer Risk Estimation Models to Identify Women Eligible for Genetic Testing and Risk-Reducing Surgery.

Author

Irelli, Azzurra, Patruno, Leonardo Valerio, Chiatamone Ranieri, Sofia, Di Giacomo, Daniela, Malatesta, Sara, Alesse, Edoardo, Tessitore, Alessandra, and Cannita, Katia

Subjects
GENETIC testing, BREAST cancer, DISEASE risk factors, OVARIAN cancer, CHECKPOINT kinase 2, PRENATAL genetic testing
Abstract

Hereditary breast and ovarian cancer (HBOC) syndrome is responsible for approximately 10% of breast cancers (BCs). The HBOC gene panel includes both high-risk genes, i.e., a four times higher risk of BC (BRCA1, BRCA2, PALB2, CDH1, PTEN, STK11 and TP53), and moderate-risk genes, i.e., a two to four times higher risk of BC (BARD1, CHEK2, RAD51C, RAD51D and ATM). Pathogenic germline variants (PGVs) in HBOC genes confer an absolute risk of BC that changes according to the gene considered. We illustrate and compare different BC risk estimation models, also describing their limitations. These models allow us to identify women eligible for genetic testing and possibly to offer surgical strategies for primary prevention, i.e., risk-reducing mastectomies and salpingo-oophorectomies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Weighing the role of skeletal muscle mass and muscle density in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: a multicenter real-life study

Author

Cortellini, Alessio, Bozzetti, Federico, Palumbo, Pierpaolo, Brocco, Davide, Di Marino, Pietro, Tinari, Nicola, De Tursi, Michele, Agostinelli, Veronica, Patruno, Leonardo, Valdesi, Cristina, Mereu, Manuela, Verna, Lucilla, Lanfiuti Baldi, Paola, Venditti, Olga, Cannita, Katia, Masciocchi, Carlo, Barile, Antonio, McQuade, Jennifer Leigh, Ficorella, Corrado, and Porzio, Giampiero

Published
2020
Full Text
View/download PDF

5. Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status

Author

Irelli, Azzurra, primary, Parisi, Alessandro, additional, D’Orazio, Carla, additional, Sidoni, Tina, additional, Rotondaro, Silvia, additional, Patruno, Leonardo, additional, Pavese, Francesco, additional, Bafile, Alberto, additional, Resta, Valter, additional, Pizzorno, Laura, additional, Ciuffetelli, Virginia, additional, Dalmas, Antonella, additional, Calvisi, Giuseppe, additional, Di Sibio, Alessandra, additional, Marzullo, Anna, additional, Zelli, Veronica, additional, Compagnoni, Chiara, additional, Tessitore, Alessandra, additional, Alesse, Edoardo, additional, Ficorella, Corrado, additional, Cortellini, Alessio, additional, and Cannita, Katia, additional

Published
2022
Full Text
View/download PDF

7. Concurrent RAS and RAS/BRAF V600E variants in colorectal cancer: more frequent than expected?

Author

Zelli, Veronica, Parisi, Alessandro, Patruno, LEONARDO VALERIO, Katia, Cannita, Ficorella, Corrado, Luzi, Carla, Compagnoni, Chiara, Zazzeroni, Francesca, Alesse, Edoardo, and Tessitore, Alessandra

Subjects
concurrent RAS/BRAF variants, colorectal cancer, concurrent RAS/BRAF variants, case report, mutation frequency, Q9 clinical–pathological features, Q9 clinical–pathological features, case report, colorectal cancer, mutation frequency
Published
2022

8. Post-Induction Management in Patients With Left-Sided RAS and BRAF Wild-Type Metastatic Colorectal Cancer Treated With First-Line Anti-EGFR-Based Doublet Regimens: A Multicentre Study

Author

Parisi, Alessandro, primary, Cortellini, Alessio, additional, Venditti, Olga, additional, Filippi, Roberto, additional, Salvatore, Lisa, additional, Tortora, Giampaolo, additional, Ghidini, Michele, additional, Nigro, Olga, additional, Gelsomino, Fabio, additional, Zurlo, Ina Valeria, additional, Fulgenzi, Claudia, additional, Lombardi, Pasquale, additional, Roselló Keränen, Susana, additional, Depetris, Ilaria, additional, Giampieri, Riccardo, additional, Morelli, Cristina, additional, Di Marino, Pietro, additional, Di Pietro, Francesca Romana, additional, Zanaletti, Nicoletta, additional, Vitale, Pasquale, additional, Garajova, Ingrid, additional, Spinelli, Gian Paolo, additional, Zoratto, Federica, additional, Roberto, Michela, additional, Petrillo, Angelica, additional, Aimar, Giacomo, additional, Patruno, Leonardo, additional, D’Orazio, Carla, additional, Ficorella, Corrado, additional, Ferri, Claudio, additional, and Porzio, Giampiero, additional

Published
2021
Full Text
View/download PDF

9. Effect of concomitant medications with immune-modulatory properties on the outcomes of patients with advanced cancer treated with immune checkpoint inhibitors: development and validation of a novel prognostic index

Author

Buti, Sebastiano, primary, Bersanelli, Melissa, additional, Perrone, Fabiana, additional, Tiseo, Marcello, additional, Tucci, Marco, additional, Adamo, Vincenzo, additional, Stucci, Luigia S., additional, Russo, Alessandro, additional, Tanda, Enrica T., additional, Spagnolo, Francesco, additional, Rastelli, Francesca, additional, Pergolesi, Federica, additional, Santini, Daniele, additional, Russano, Marco, additional, Anesi, Cecilia, additional, Giusti, Raffaele, additional, Filetti, Marco, additional, Marchetti, Paolo, additional, Botticelli, Andrea, additional, Gelibter, Alain, additional, Occhipinti, Mario Alberto, additional, Ferrari, Marco, additional, Vitale, Maria Giuseppa, additional, Nicolardi, Linda, additional, Chiari, Rita, additional, Rijavec, Erika, additional, Nigro, Olga, additional, Tuzi, Alessandro, additional, De Tursi, Michele, additional, Di Marino, Pietro, additional, Conforti, Fabio, additional, Queirolo, Paola, additional, Bracarda, Sergio, additional, Macrini, Serena, additional, Gori, Stefania, additional, Zoratto, Federica, additional, Veltri, Enzo, additional, Di Cocco, Barbara, additional, Mallardo, Domenico, additional, Vitale, Maria Grazia, additional, Santoni, Matteo, additional, Patruno, Leonardo, additional, Porzio, Giampiero, additional, Ficorella, Corrado, additional, Pinato, David J., additional, Ascierto, Paolo A., additional, and Cortellini, Alessio, additional

Published
2021
Full Text
View/download PDF

10. Weighing the role of concomitant medications during PD-1/PD-L1 checkpoint blockade: A preliminary analysis.

Author

Cortellini, Alessio, primary, Mallardo, Domenico, additional, Vitale, Maria Grazia, additional, Bracarda, Sergio, additional, Macrini, Serena, additional, Di Marino, Pietro, additional, De Tursi, Michele, additional, Petragnani, Nicola, additional, Natoli, Clara, additional, Nigro, Olga, additional, Tuzi, Alessandro, additional, Patruno, Leonardo Valerio, additional, Porzio, Giampiero, additional, Cannita, Katia, additional, Fargnoli, Maria Concetta, additional, Ficorella, Corrado, additional, and Ascierto, Paolo Antonio, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results