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2. Supplementary Figure 1 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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3. Supplementary Figure 9 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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4. Supplementary Table 1 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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5. Supplementary Figure 2 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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6. Supplementary Figure 7 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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7. Supplementary Figure 6 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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8. Supplementary Figure 3 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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9. Supplementary Figure 8 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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10. Supplementary Table 2 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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11. Supplementary Table 4 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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12. Supplementary Figure 4 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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13. Supplementary Figure 5 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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14. Supplementary Table 3 from Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, primary, Solomon, David A., primary, Hariono, Sujatmi, primary, Hashizume, Rintaro, primary, Barkovich, Krister, primary, Baker, Suzanne J., primary, Paugh, Barbara S., primary, Jones, Chris, primary, Forshew, Tim, primary, Hindley, Guy F., primary, Hodgson, J. Graeme, primary, Kim, Jung-Sik, primary, Rowitch, David H., primary, Weiss, William A., primary, Waldman, Todd A., primary, and James, C. David, primary

Published
2023
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15. Supplementary Table 2 from Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Author

Paugh, Barbara S., primary, Zhu, Xiaoyan, primary, Qu, Chunxu, primary, Endersby, Raelene, primary, Diaz, Alexander K., primary, Zhang, Junyuan, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Reis, Rui M., primary, Onar-Thomas, Arzu, primary, Broniscer, Alberto, primary, Wetmore, Cynthia, primary, Zhang, Jinghui, primary, Jones, Chris, primary, Ellison, David W., primary, and Baker, Suzanne J., primary

Published
2023
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16. Data from Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Author

Paugh, Barbara S., primary, Zhu, Xiaoyan, primary, Qu, Chunxu, primary, Endersby, Raelene, primary, Diaz, Alexander K., primary, Zhang, Junyuan, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Reis, Rui M., primary, Onar-Thomas, Arzu, primary, Broniscer, Alberto, primary, Wetmore, Cynthia, primary, Zhang, Jinghui, primary, Jones, Chris, primary, Ellison, David W., primary, and Baker, Suzanne J., primary

Published
2023
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17. Supplementary Table 1 from Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Author

Paugh, Barbara S., primary, Zhu, Xiaoyan, primary, Qu, Chunxu, primary, Endersby, Raelene, primary, Diaz, Alexander K., primary, Zhang, Junyuan, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Reis, Rui M., primary, Onar-Thomas, Arzu, primary, Broniscer, Alberto, primary, Wetmore, Cynthia, primary, Zhang, Jinghui, primary, Jones, Chris, primary, Ellison, David W., primary, and Baker, Suzanne J., primary

Published
2023
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18. Supplementary Table 3 from Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Author

Paugh, Barbara S., primary, Zhu, Xiaoyan, primary, Qu, Chunxu, primary, Endersby, Raelene, primary, Diaz, Alexander K., primary, Zhang, Junyuan, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Reis, Rui M., primary, Onar-Thomas, Arzu, primary, Broniscer, Alberto, primary, Wetmore, Cynthia, primary, Zhang, Jinghui, primary, Jones, Chris, primary, Ellison, David W., primary, and Baker, Suzanne J., primary

Published
2023
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19. Supplementary Table 4 from Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Author

Paugh, Barbara S., primary, Zhu, Xiaoyan, primary, Qu, Chunxu, primary, Endersby, Raelene, primary, Diaz, Alexander K., primary, Zhang, Junyuan, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Reis, Rui M., primary, Onar-Thomas, Arzu, primary, Broniscer, Alberto, primary, Wetmore, Cynthia, primary, Zhang, Jinghui, primary, Jones, Chris, primary, Ellison, David W., primary, and Baker, Suzanne J., primary

Published
2023
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20. Supplementary Figure Legends and Figures from Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Author

Paugh, Barbara S., primary, Zhu, Xiaoyan, primary, Qu, Chunxu, primary, Endersby, Raelene, primary, Diaz, Alexander K., primary, Zhang, Junyuan, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Reis, Rui M., primary, Onar-Thomas, Arzu, primary, Broniscer, Alberto, primary, Wetmore, Cynthia, primary, Zhang, Jinghui, primary, Jones, Chris, primary, Ellison, David W., primary, and Baker, Suzanne J., primary

Published
2023
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21. Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

Author

Wang, Hong, Diaz, Alexander K., Shaw, Timothy I., Li, Yuxin, Niu, Mingming, Cho, Ji-Hoon, Paugh, Barbara S., Zhang, Yang, Sifford, Jeffrey, Bai, Bing, Wu, Zhiping, Tan, Haiyan, Zhou, Suiping, Hover, Laura D., Tillman, Heather S., Shirinifard, Abbas, Thiagarajan, Suresh, Sablauer, Andras, Pagala, Vishwajeeth, High, Anthony A., Wang, Xusheng, Li, Chunliang, Baker, Suzanne J., and Peng, Junmin

Published
2019
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24. Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

Author

Larson, Jon D., primary, Kasper, Lawryn H., additional, Paugh, Barbara S., additional, Jin, Hongjian, additional, Wu, Gang, additional, Kwon, Chang-Hyuk, additional, Fan, Yiping, additional, Shaw, Timothy I., additional, Silveira, André B., additional, Qu, Chunxu, additional, Xu, Raymond, additional, Zhu, Xiaoyan, additional, Zhang, Junyuan, additional, Russell, Helen R., additional, Peters, Jennifer L., additional, Finkelstein, David, additional, Xu, Beisi, additional, Lin, Tong, additional, Tinkle, Christopher L., additional, Patay, Zoltan, additional, Onar-Thomas, Arzu, additional, Pounds, Stanley B., additional, McKinnon, Peter J., additional, Ellison, David W., additional, Zhang, Jinghui, additional, and Baker, Suzanne J., additional

Published
2019
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25. Abstract 3006: Oncogenic activity of H3.3 K27M in a spontaneous DIPG mouse model

Author

Larson, Jon D., primary, Kasper, Lawryn H., additional, Wu, Gang, additional, Fan, Yiping, additional, Finkelstein, David, additional, Jin, Hongjian, additional, Paugh, Barbara S., additional, Silveira, Andre B., additional, Xu, Beisi, additional, Zhu, Xiaoyan, additional, Zhang, Junyuan, additional, Russell, Helen R., additional, McKinnon, Peter J., additional, Ellison, David W., additional, Zhang, Jinghui, additional, and Baker, Suzanne J., additional

Published
2017
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26. Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Author

Paugh, Barbara S., primary, Zhu, Xiaoyan, additional, Qu, Chunxu, additional, Endersby, Raelene, additional, Diaz, Alexander K., additional, Zhang, Junyuan, additional, Bax, Dorine A., additional, Carvalho, Diana, additional, Reis, Rui M., additional, Onar-Thomas, Arzu, additional, Broniscer, Alberto, additional, Wetmore, Cynthia, additional, Zhang, Jinghui, additional, Jones, Chris, additional, Ellison, David W., additional, and Baker, Suzanne J., additional

Published
2013
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27. Targeted Therapy for BRAFV600E Malignant Astrocytoma

Author

Nicolaides, Theodore P., primary, Li, Huifang, additional, Solomon, David A., additional, Hariono, Sujatmi, additional, Hashizume, Rintaro, additional, Barkovich, Krister, additional, Baker, Suzanne J., additional, Paugh, Barbara S., additional, Jones, Chris, additional, Forshew, Tim, additional, Hindley, Guy F., additional, Hodgson, J. Graeme, additional, Kim, Jung-Sik, additional, Rowitch, David H., additional, Weiss, William A., additional, Waldman, Todd A., additional, and James, C. David, additional

Published
2011
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28. Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma

Author

Paugh, Barbara S., primary, Broniscer, Alberto, additional, Qu, Chunxu, additional, Miller, Claudia P., additional, Zhang, Junyuan, additional, Tatevossian, Ruth G., additional, Olson, James M., additional, Geyer, J. Russell, additional, Chi, Susan N., additional, da Silva, Nasjla Saba, additional, Onar-Thomas, Arzu, additional, Baker, Justin N., additional, Gajjar, Amar, additional, Ellison, David W., additional, and Baker, Suzanne J., additional

Published
2011
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29. Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease

Author

Paugh, Barbara S., primary, Qu, Chunxu, additional, Jones, Chris, additional, Liu, Zhaoli, additional, Adamowicz-Brice, Martyna, additional, Zhang, Junyuan, additional, Bax, Dorine A., additional, Coyle, Beth, additional, Barrow, Jennifer, additional, Hargrave, Darren, additional, Lowe, James, additional, Gajjar, Amar, additional, Zhao, Wei, additional, Broniscer, Alberto, additional, Ellison, David W., additional, Grundy, Richard G., additional, and Baker, Suzanne J., additional

Published
2010
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30. Sphingosine-1-Phosphate and Interleukin-1 Independently Regulate Plasminogen Activator Inhibitor-1 and Urokinase-Type Plasminogen Activator Receptor Expression in Glioblastoma Cells: Implications for Invasiveness

Author

Bryan, Lauren, primary, Paugh, Barbara S., additional, Kapitonov, Dmitri, additional, Wilczynska, Katarzyna M., additional, Alvarez, Silvina M., additional, Singh, Sandeep K., additional, Milstien, Sheldon, additional, Spiegel, Sarah, additional, and Kordula, Tomasz, additional

Published
2008
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31. EGF regulates plasminogen activator inhibitor‐1 (PAI‐1) by a pathway involving c‐Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells

Author

Paugh, Barbara S., primary, Paugh, Steven W., additional, Bryan, Lauren, additional, Kapitonov, Dmitri, additional, Wilczynska, Katarzyna M., additional, Gopalan, Sunita M., additional, Rokita, Hanna, additional, Milstien, Sheldon, additional, Spiegel, Sarah, additional, and Kordula, Tomasz, additional

Published
2007
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32. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.

Author

Wu, Gang, Diaz, Alexander K, Paugh, Barbara S, Rankin, Sherri L, Ju, Bensheng, Li, Yongjin, Zhu, Xiaoyan, Qu, Chunxu, Chen, Xiang, Zhang, Junyuan, Easton, John, Edmonson, Michael, Ma, Xiaotu, Lu, Charles, Nagahawatte, Panduka, Hedlund, Erin, Rusch, Michael, Pounds, Stanley, Lin, Tong, and Onar-Thomas, Arzu

Subjects
GLIOMAS, BRAIN stem, GENETIC mutation, CELL cycle regulation, NEUROTROPHIN receptors, HISTONES
Abstract

Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGGs (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing. We identified recurrent somatic mutations in ACVR1 exclusively in DIPGs (32%), in addition to previously reported frequent somatic mutations in histone H3 genes, TP53 and ATRX, in both DIPGs and NBS-HGGs. Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40% of NBS-HGGs in infants. Mutations targeting receptor tyrosine kinase-RAS-PI3K signaling, histone modification or chromatin remodeling, and cell cycle regulation were found in 68%, 73% and 59% of pediatric HGGs, respectively, including in DIPGs and NBS-HGGs. This comprehensive analysis provides insights into the unique and shared pathways driving pediatric HGG within and outside the brainstem. [ABSTRACT FROM AUTHOR]

Published
2014
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33. EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells.

Author

Paugh, Barbara S., Paugh, Steven W., Bryan, Lauren, Kapitonov, Dmitri, Wilczynska, Katarzyna M., Gopalan, Sunita M., Rokita, Hanna, Milstien, Sheldon, Spiegel, Sarah, and Kordula, Tomasz

Subjects
*EPIDERMAL growth factor, *PLASMINOGEN activators, *PROTEIN kinase C, *SPHINGOSINE, *GLIOMAS
Abstract

Patients with gliomas expressing high levels of epidermal growth factor receptor (EGFR) and plasminogen activator inhibitor-1 (PAI-1) have a shorter overall survival prognosis. Moreover, EGF enhances PAI-1 expression in glioma cells. Although multiple known signaling cascades are activated by EGF in glioma cells, we show for the first time that EGF enhances expression of PAI-1 via sequential activation of c-Src, protein kinase C delta (PKCδ), and sphingosine kinase 1 (SphK1), the enzyme that produces sphingosine-1-phosphate. EGF induced rapid phosphorylation of c-Src and PKCδ and concomitant translocation of PKCδ as well as SphK1 to the plasma membrane. Down-regulation of PKCδ abolished EGF-induced SphK1 translocation and up-regulation of PAI-1 by EGF; whereas, down-regulation of PKCα had no effect on the EGF-induced PAI-1 activation but enhanced its basal expression. Similarly, inhibition of c-Src activity by PP2 blocked both EGF-induced translocation of SphK1 and PKCδ to the plasma membrane and up-regulation of PAI-1 expression. Furthermore, SphK1 was indispensable for both EGF-induced c-Jun phosphorylation and PAI-1 expression. Collectively, our results provide a functional link between three critical downstream targets of EGF, c-Src, PKCδ and SphK1 that have all been implicated in regulating motility and invasion of glioma cells. [ABSTRACT FROM AUTHOR]

Published
2008
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34. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

Author

Wu, Gang, Broniscer, Alberto, McEachron, Troy A, Lu, Charles, Paugh, Barbara S, Becksfort, Jared, Qu, Chunxu, Ding, Li, Huether, Robert, Parker, Matthew, Zhang, Junyuan, Gajjar, Amar, Dyer, Michael A, Mullighan, Charles G, Gilbertson, Richard J, Mardis, Elaine R, Wilson, Richard K, Downing, James R, Ellison, David W, and Zhang, Jinghui

Subjects
SOMATIC cells, GENETIC mutation, GLIOMAS, BRAIN stem, HISTONES
Abstract

To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration. [ABSTRACT FROM AUTHOR]

Published
2012
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