Search

Your search keyword '"Paul Dickman"' showing total 18 results
Start Over Author "Paul Dickman"
18 results on '"Paul Dickman"'

1. ATF6α Activation Enhances Survival against Chemotherapy and Serves as a Prognostic Indicator in Osteosarcoma

Author

Suma Yarapureddy, Jazmine Abril, Janet Foote, Saravana Kumar, Omar Asad, Veena Sharath, Janine Faraj, Dustin Daniel, Paul Dickman, Andrea White-Collins, Pooja Hingorani, and Aparna R Sertil

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Patients with metastatic or relapsed/refractory osteosarcoma (OS) have a 5-year survival rate of

Published
2019
Full Text
View/download PDF

3. Maternal suicide - Register based study of all suicides occurring after delivery in Sweden 1974-2009.

Author

Henrik Lysell, Marie Dahlin, Alexander Viktorin, Elsa Ljungberg, Brian M D'Onofrio, Paul Dickman, and Bo Runeson

Subjects
Medicine, Science
Abstract

Recent research suggests that having a newborn child is associated with substantially reduced risk for maternal suicide. We studied postpartum suicides in a national cohort of mothers and the role of mental disorder, self-harm and delivery related factors.We used a nested case-control design with data from Swedish registries. The cohort consisted of all women given birth in Sweden 1974-2009. Mothers who died by suicide during follow-up were considered cases (n = 1,786) and risk of suicide was estimated with proximity to delivery as the explanatory variable. In a second step, association between suicide during the first year following delivery (n = 145) and mental disorder, self-harm and delivery related variables risk factors were analyzed.The first postpartum year was associated with a lower risk of suicide, compared to later (RR 0.80, 95%CI 0.66-0.96), which was unaltered after adjustment for socio-economic status and history of self-harm (aRR 0.82, 95%CI 0.68-0.99). Compared to living mothers, suicide victims of the postpartum year more often had affective disorders (aRR 133.94, 95%CI 45.93-390.61), psychotic disorders (aRR 83.69, 95%CI 36.99-189.31) and history of self-harm (aRR 47.56, 95%CI 18.24-124.02). The aRR of stillbirth was 2.66 (95%CI 0.63-11.30).We found only a weak negative association between childbirth during the preceding year and suicide, when using mothers as controls. A severe mental disorder after delivery and a history of self-harm was strongly associated with increased risk of suicide in the postpartum year and may inform the clinical assessment postpartum.

Published
2018
Full Text
View/download PDF

4. The Miniproject: An initial step in scientific research skill development for first-semester medical students

Author

Jennifer LP Protudjer, Riitta Möller, Matti J Nikkola, Paul Dickman, and Amelie Plymoth

Subjects
Clinician-scientist, Medical education, Self-directed learning, Special aspects of education, LC8-6691, Medicine
Abstract

Although medical students involved in research training express greater interest in academic medicine, a paucity of clinician-scientists remains. Herein, we describe a feasible project, titled 'The Miniproject,' which introduces first-semester medical students to basic concepts in scientific research. The Miniproject was introduced in 2007 as part of a major curriculum reform to provide a structured, systematic approach to scientific training to Karolinska Institute's study programme in Medicine. The Miniproject itself was developed in recognition that emphasis is increasingly placed on student-centred study, which involves greater assumption of responsibility by the student for his or her own learning. Over the course of five days during the first weeks of medical school, students participate in a variety of activities designed to align with five intended learning outcomes. These intended learning outcomes include: formulating a scientific hypothesis; discussing, in broad terms, at least one method used to answer a scientific question; giving and receiving feedback from peers and teachers; demonstrating the ability to search, interpret, present and discuss written and oral scientific medical information; and actively engaging in a small group discussion. Teachers facilitate small group discussions, but encourage students to lead these discussions. Via electronic, anonymous evaluations, most students (65.1%) evaluated the Miniproject as good or very good. In conclusion, the Miniproject is a feasible project led by researchers, and which is designed to introduce first-semester medical students to scientific literature and the research process, as initial steps in the scientific development thread.

Published
2016

5. Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

Author

Naomi Ssenyonga, Charles Stiller, Kayo Nakata, Jaime Shalkow, Shelagh Redmond, Jean-Luc Bulliard, Fabio Girardi, Christine Fowler, Rafael Marcos-Gragera, Audrey Bonaventure, Nathalie Saint-Jacques, Pamela Minicozzi, Prithwish De, Miguel Rodríguez-Barranco, Siri Larønningen, Veronica Di Carlo, Margit Mägi, Mikhail Valkov, Karri Seppä, Dyfed Wyn Huws, Michel P Coleman, Claudia Allemani, Sabiha Bouzbid, Mokhtar Hamdi-Chérif, Lamia Kara, Kaouel Meguenni, Derbali Regagba, Sine Bayo, Traore Cheick Bougadari, Shyam Shunker Manraj, Karima Bendahhou, Akinade Ladipo, Olufemi Ogunbiyi, Nontuthuzelo Somdyala, María Agustina Chaplin, Florencia Moreno, Gladis Calabrano, Silvia Espinola, Beatriz Carballo Quintero, Rosalba Fita, Walter Laspada, Susana Ibañez, Carlos Lima, Allini Mafra Da Costa, Paulo César De Souza, Juliana Chaves, Cyntia Laporte, Maria Paula Curado, Jose Carlos de Oliveira, Claudia Veneziano, Donaldo Veneziano, Ana Beatriz Almeida, Maria Latorre, Gulnar Azevedo e Silva, Marise Rebelo, Marceli Santos, Juan Galaz, Mackarena Aparicio Aravena, Jocelyn Sanhueza Monsalve, Denise Herrmann, Solange Vargas, Victor Herrera, Claudia Uribe, Luis Eduardo Bravo, Luz Stella Garcia, Nelson Arias-Ortiz, Daniela Morantes, Daniel Jurado, María Yépez Chamorro, Sandra Delgado, Melissa Ramirez, Yaima Galán Alvarez, Priscila Torres, Fray Martínez-Reyes, Leyda Jaramillo, Rina Quinto, Jhoanna Castillo, Mariela Mendoza, Patricia Cueva, José Yépez, Bernard Bhakkan, Jacqueline Deloumeaux, Clarisse Joachim, Jonathan Macni, Rodolfo Carrillo, Jaime Shalkow Klincovstein, Rebeca Rivera Gomez, Patricia Perez, Ebert Poquioma, Guillermo Tortolero-Luna, Diego Zavala, Rafael Alonso, Enrique Barrios, Angela Eckstrand, Cindy Nikiforuk, Ryan Woods, Gail Noonan, Donna Turner, Eshwar Kumar, Bin Zhang, Jeff Dowden, Gregory Doyle, Gordon Walsh, Aniq Anam, Carol McClure, Kim Vriends, Christine Bertrand, Agnihotram Ramanakumar, Serena Kozie, Heather Stuart-Panko, Tara Freeman, Justin George, Rosa Avila, David O'Brien, Abby Holt, Lyn Almon, Kevin Ward, Sandy Kwong, Cyllene Morris, Randi Rycroft, Lloyd Mueller, Cathryn Phillips, Heather Brown, Betsy Cromartie, Julie Ruterbusch, Ann Schwartz, Gary Levin, Brad Wohler, Rana Bayakly, Scarlett Gomez, Meg McKinley, Rosemary Cress, Joni Davis, Brenda Hernandez, Christopher Johnson, Bozena Morawski, Laura Ruppert, Suzanne Bentler, Mary Charlton, Bin Huang, Thomas Tucker, Dennis Deapen, Lihua Liu, Mei-Chin Hsieh, Xiao-Cheng Wu, Molly Schwenn, Kimberly Stern, Susan Gershman, Richard Knowlton, Georgetta Alverson, Tamara Weaver, Jay Desai, Deirdre Rogers, Jeanette Jackson-Thompson, Debbi Lemons, Heather Zimmerman, Michelle Hood, Jenifer Roberts-Johnson, Whitney Hammond, Judith Rees, Karen Pawlish, Antoinette Stroup, Charles Key, Charles Wiggins, Amy Kahn, Maria Schymura, Soundarya Radhakrishnan, Chandrika Rao, Lynn Giljahn, Roberta Slocumb, Christy Dabbs, Raffaella Espinoza, Karen Aird, Todd Beran, Jim Rubertone, Stephen Slack, Junhie Oh, Tiffany Janes, Stephen Schwartz, Stephanie Chiodini, Deborah Hurley, Martin Whiteside, Saroj Rai, Melanie Williams, Kim Herget, Carol Sweeney, Alison Johnson, Mahesh Keitheri Cheteri, Patti Migliore Santiago, Steven Blankenship, Shawn Farley, Robert Borchers, Robin Malicki, Julia Espinoza, Joseph Grandpre, Brenda Edwards, Angela Mariotto, Hannah Weir, Reda Wilson, Ning Wang, Lei Yang, Jian-Shun Chen, Yu-Tong He, Guo-Hui Song, Xiao-Ping Gu, Dan Mei, Heng-Ming Ge, Tong-Hao Wu, Yan-Yan Li, De-Li Zhao, Feng Jin, Jian-Hua Zhang, Feng-Dong Zhu, Qian Junhua, Yan Lei Yang, Chun-Xiao Jiang, Wang Biao, Jian Wang, Qi-Long Li, He Yi, Xin Zhou, JianMei Dong, WeiWei Li, Fang-Xian Fu, Jian-Guo Chen, Jian Zhu, Yan-Hua Li, Yu-Qiang Lu, Min Fan, Su-Qin Huang, Guo-Ping Guo, Hua Zhaolai, Kuangrong Wei, Wan-Qing Chen, Wenqiang Wei, Hongmei Zeng, Anna Demetriou, Wai Kong Mang, Kai Cheong Ngan, Amal Kataki, Manigreeva Krishnatreya, Padmavathi Amma Jayalekshmi, Paul Sebastian, Preethi George, Aleyamma Mathew, Ambakumar Nandakumar, Reza Malekzadeh, Gholamreza Roshandel, Lital Keinan-Boker, Barbara Silverman, Hidemi Ito, Yuriko Koyanagi, Masako Sato, Fumio Tobori, Ichiro Nakata, Norihiro Teramoto, Masakazu Hattori, Yasuharu Kaizaki, Fumitaka Moki, Hiromi Sugiyama, Mai Utada, Makiko Nishimura, Keiichi Yoshida, Katsuki Kurosawa, Yuji Nemoto, Hiroto Narimatsu, Masahiko Sakaguchi, Seiki Kanemura, Michiko Naito, Rintaro Narisawa, Isao Miyashiro, Daisuke Mori, Mayuko Yoshitake, Izumi Oki, Norimasa Fukushima, Akiko Shibata, Keiichiro Iwasa, Chie Ono, Tomohiro Matsuda, Omar Nimri, Kyu-Won Jung, Young-Joo Won, Eiman Alawadhi, Amani Elbasmi, Azizah Ab Manan, Farzaana Adam, Erdenekhuu Nansalmaa, Undarmaa Tudev, Chimedsuren Ochir, Al Hareth Al Khater, Mufid El Mistiri, Gek Hsiang Lim, Yik Ying Teo, Chun-Ju Chiang, Wen-Chung Lee, Rangsiya Buasom, Suleeporn Sangrajrang, Krittika Suwanrungruang, Patravoot Vatanasapt, Karnchana Daoprasert, Donsuk Pongnikorn, Atit Leklob, Somphob Sangkitipaiboon, Sarayut Geater, Hutcha Sriplung, Okan Ceylan, Iskender Kög, Oya Dirican, Tülay Köse, Tulın Gurbuz, Füsun Emine Karašahin, Duygu Turhan, Umut Aktaş, Yakup Halat, Sultan Eser, Cankut Yakut, Merve Altinisik, Yasar Cavusoglu, Ayşe Türkköylü, Nuršen Üçüncü, Monika Hackl, Anna Zborovskaya, Olga Aleinikova, Kris Henau, Liesbet Van Eycken, Trayan Atanasov, Zdravka Valerianova, Mario Šekerija, Ladislav Dušek, Miroslav Zvolský, Lina Steinrud Mørch, Hans Storm, Charlotte Wessel Skovlund, Kaire Innos, Nea Malila, Jérémie Jégu, Michel Velten, Edouard Cornet, Xavier Troussard, Anne-Marie Bouvier, Anne-Valérie Guizard, Véronique Bouvier, Guy Launoy, Sandrine Dabakuyo Yonli, Marie-Laure Poillot, Marc Maynadié, Morgane Mounier, Lina Vaconnet, Anne-Sophie Woronoff, Mélanie Daoulas, Michel Robaszkiewicz, Jacqueline Clavel, Claire Poulalhon, Emmanuel Desandes, Brigitte Lacour, Isabelle Baldi, Camille Pouchieu, Brice Amadeo, Gaëlle Coureau, Alain Monnereau, Magali Audoin, Tania D'Almeida, Séverine Boyer, Karima Hammas, Brigitte Trétarre, Marc Colonna, Patricia Delafosse, Sandrine Plouvier, Anne Cowppli-Bony, Florence Molinié, Simona Bara, Olivier Ganry, Bénédicte Lapôtre-Ledoux, Laetitia Daubisse-Marliac, Nadine Bossard, Jacques Estève, Zoé Uhry, Roland Stabenow, Heide Wilsdorf-Köhler, Andrea Eberle, Sabine Luttmann, Imma Löhden, Alice Nennecke, Joachim Kieschke, Eunice Sirri, Christina Justenhoven, Sylke Zeissig, Bernd Holleczek, Nora Eisemann, Alexander Katalinic, Rachelle Asquez, Vijay Kumar, Eleni Petridou, Elínborg Ólafsdóttir, Laufey Tryggvadóttir, Deirdre Murray, Paul Walsh, Hildrun Sundseth, Guido Mazzoleni, Fabio Vittadello, Enzo Coviello, Francesco Cuccaro, Rocco Galasso, Giuseppe Sampietro, Michele Magoni, Antonino Ardizzone, Angelo D'Argenzio, Alessia Anna Di Prima, Antonella Ippolito, Anna Maria Lavecchia, Antonella Sutera Sardo, Gemma Gola, Paola Ballotari, Erica Giacomazzi, Stefano Ferretti, Luigino Dal Maso, Diego Serraino, Maria Vittoria Celesia, Rosa Angela Filiberti, Fabio Pannozzo, Anna Melcarne, Fabrizio Quarta, Anita Andreano, Antonio Giampiero Russo, Giuliano Carrozzi, Claudia Cirilli, Luca Cavalieri d'Oro, Magda Rognoni, Mario Fusco, Maria Francesca Vitale, Mario Usala, Rosanna Cusimano, Walter Mazzucco, Maria Michiara, Paolo Sgargi, Lorenza Boschetti, Giorgio Chiaranda, Pietro Seghini, Milena Maule, Franco Merletti, Eugenia Spata, Rosario Tumino, Pamela Mancuso, Massimo Vicentini, Tiziana Cassetti, Romano Sassatelli, Fabio Falcini, Stefania Giorgetti, Anna Luisa Caiazzo, Rossella Cavallo, Daniela Piras, Francesca Bella, Anselmo Madeddu, Anna Clara Fanetti, Sergio Maspero, Simona Carone, Antonia Mincuzzi, Giuseppa Candela, Tiziana Scuderi, Maria Adalgisa Gentilini, Roberto Rizzello, Stefano Rosso, Roberto Zanetti, Adele Caldarella, Teresa Intrieri, Fortunato Bianconi, Fabrizio Stracci, Paolo Contiero, Giovanna Tagliabue, Massimo Rugge, Manuel Zorzi, Simonetta Beggiato, Angelita Brustolin, Roberta De Angelis, Gemma Gatta, Anita Maurina, Marija Oniščuka, Mohsen Mousavi, Nadezda Lipunova, Ieva Vincerzevskienė, Dominic Agius, Neville Calleja, Sabine Siesling, Otto Visser, Tom Johannesen, Maciej Trojanowski, Tomasz Mierzwa, Jadwiga Rachtan, Kamila Kępska, Beata Kościańska, Joanna Wójcik-Tomaszewska, Marcin Motnyk, Anna Gos, Magdalena Bielska-Lasota, Joanna Didkowska, Urszula Wojciechowska, Gonçalo Forjaz de Lacerda, Raul Rego, Branca Carrito, Ana Pais, Maria José Bento, Jessica Rodrigues, Antonio Lourenço, Alexandra Mayer-da-Silva, Luminita Blaga, Daniela Coza, Lubov Gusenkova, Olga Lazarevich, Olga Prudnikova, Dmitri Mikhailovich Vjushkov, Alla Egorova, Andrey Orlov, Lidiya Pikalova, Lilia Zhuikova, Juraj Adamcik, Chakameh Safaei Diba, Vesna Zadnik, Tina Zagar, Marta De-La-Cruz, Arantza Lopez-de-Munain, Araceli Aleman, Dolores Rojas, Rosario Jiménez Chillarón, Ana Isabel Marcos Navarro, Montse Puigdemont, María-José Sánchez Perez, Paula Franch Sureda, Maria Ramos Montserrat, Maria Dolores Chirlaque López, Antonia Sánchez Gil, Eva Ardanaz, Marcela Guevara, Adela Cañete-Nieto, Rafael Peris-Bonet, Marià Carulla, Jaume Galceran, Fernando Almela, Consol Sabater, Staffan Khan, David Pettersson, Paul Dickman, Katharina Staehelin, Benjamin Struchen, Christian Herrmann, Seyed Mohsen Mousavi, Céline Egger Hayoz, Christine Bouchardy, Robin Schaffar, Philip Went, Manuela Maspoli-Conconi, Claudia Kuehni, Andrea Bordoni, Laura Ortelli, Arnaud Chiolero, Isabelle Konzelmann, Sabine Rohrmann, Miriam Wanner, John Broggio, Jem Rashbass, Deirdre Fitzpatrick, Anna Gavin, David Morrison, Catherine Thomson, Giles Greene, Dyfed Huws, Michel Coleman, Melissa Matz, Natalia Sanz, Richard Stephens, Elizabeth Chalker, Mirka Smith, Jessica Gugusheff, Hui You, Shu Qin Li, Sarah Dugdale, Julie Moore, Shoni Philpot, Rhonda Pfeiffer, Helen Thomas, Bruna Silva Ragaini, Alison Venn, Sue Evans, Luc Te Marvelde, Vedrana Savietto, Richard Trevithick, David Currow, Chris Lewis, Ssenyonga, Naomi, Stiller, Charle, Nakata, Kayo, Shalkow, Jaime, Redmond, Sheilagh, Bulliard, Jean-Luc, Girardi, Fabio, Fowler, Christine, Marcos-Gragera, Raphael, Bonaventure, Audrey, Saint-Jacques, Nathalie, Minicozzi, Pamela, De, Prithwish, Rodríguez-Barranco, Miguel, Larønningen, Siri, Di Carlo, Veronica, Mägi, Margit, Valkov, Mikhail, Seppä, Karri, Wyn Huws, Dyfed, Coleman, Michel P, Allemani, Claudia, and Mazzucco, Walter

Subjects
Adolescent, Australia, 610 Medicine & health, lymphoma, Settore MED/42 - Igiene Generale E Applicata, survival, United States, Europe, Leukemia, Myeloid, Acute, Young Adult, children, population-based/cancer registry, 360 Social problems & social services, survival, leukemia, cancer registry, Hematologic Neoplasms, leukaemia, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, cancer, Humans, Registries, haematological malignancy, Child
Abstract

BACKGROUND Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0-14 years) and adults (aged 15-99 years) diagnosed with a haematological malignancy during 2000-14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and morphology, in young patients (aged 0-24 years). METHODS We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3 that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0-14 years), adolescents (15-19 years), and young adults (20-24 years). We categorised leukaemia subtypes according to the International Classification of Childhood Cancer (ICCC-3), updated with International Classification of Diseases for Oncology, third edition (ICD-O-3) codes. We estimated 5-year net survival by age and morphology, with 95% CIs, using the non-parametric Pohar-Perme estimator. To control for background mortality, we used life tables by country or region, single year of age, single calendar year and sex, and, where possible, by race or ethnicity. All-age survival estimates were standardised to the marginal distribution of young people with leukaemia included in the analysis. FINDINGS 164 563 young people were included in this analysis: 121 328 (73·7%) children, 22 963 (14·0%) adolescents, and 20 272 (12·3%) young adults. In 2010-14, the most common subtypes were lymphoid leukaemia (28 205 [68·2%] patients) and acute myeloid leukaemia (7863 [19·0%] patients). Age-standardised 5-year net survival in children, adolescents, and young adults for all leukaemias combined during 2010-14 varied widely, ranging from 46% in Mexico to more than 85% in Canada, Cyprus, Belgium, Denmark, Finland, and Australia. Individuals with lymphoid leukaemia had better age-standardised survival (from 43% in Ecuador to ≥80% in parts of Europe, North America, Oceania, and Asia) than those with acute myeloid leukaemia (from 32% in Peru to ≥70% in most high-income countries in Europe, North America, and Oceania). Throughout 2000-14, survival from all leukaemias combined remained consistently higher for children than adolescents and young adults, and minimal improvement was seen for adolescents and young adults in most countries. INTERPRETATION This study offers the first worldwide picture of population-based survival from leukaemia in children, adolescents, and young adults. Adolescents and young adults diagnosed with leukaemia continue to have lower survival than children. Trends in survival from leukaemia for adolescents and young adults are important indicators of the quality of cancer management in this age group. FUNDING Children with Cancer UK, the Institut National du Cancer, La Ligue Contre le Cancer, Centers for Disease Control and Prevention, Swiss Re, Swiss Cancer Research foundation, Swiss Cancer League, Rossy Family Foundation, US National Cancer Institute, and the American Cancer Society.

Published
2022
Full Text
View/download PDF

7. BIRC5 expression is a poor prognostic marker in Ewing sarcoma

Author

Pooja, Hingorani, Paul, Dickman, Pamela, Garcia-Filion, Andrea, White-Collins, Edward A, Kolb, and David O, Azorsa

Subjects
Adult, Male, Adolescent, Survivin, Imidazoles, Apoptosis, Bone Neoplasms, Sarcoma, Ewing, Prognosis, Inhibitor of Apoptosis Proteins, Cell Line, Tumor, Child, Preschool, Humans, Female, Child, Biomarkers, Cell Proliferation, Naphthoquinones
Abstract

BIRC5 (Survivin), an inhibitor of apoptosis protein (IAP), is over-expressed in several human cancers and increased expression is associated with poor prognosis. The goal of the current study was to evaluate the role of BIRC5 in Ewing sarcoma (ES), the second most common pediatric bone sarcoma.BIRC5 protein expression was determined in ES cell lines using Western Blot analysis. Functional role of survivin on growth and viability of ES cells was assessed by siRNA knockdown of BIRC5 and by using a small molecule inhibitor YM155. Immunohistochemical analysis for BIRC5 protein was performed on patient tumor samples using an anti-survivin antibody. The degree of BIRC5 protein expression was correlated with clinical parameters and patient outcome.BIRC5 is over-expressed in a panel of ES cell lines. Gene silencing of BIRC5 in the ES cell line TC-71 decreases cell growth by more than 50% for each BIRC5 siRNA construct compared to non-silencing siRNA control constructs. YM155 also reduces ES cell growth and viability with an EC(50) ranging from 2.8 to 6.2 nM. BIRC5 protein is expressed in majority of the ES tumor samples with minimal expression in normal tissue (P0.005). Tumors with more than 50% expression are associated with worse overall survival than tumors with less than 50% expression (Hazard Ratio: 6.05; CI: 1.7-21.4; P = 0.04).BIRC5 is over-expressed in ES cell lines and tumor samples. Further, it plays an important role in cell growth and viability in vitro. Higher degree of expression in patients is an independent poor prognostic factor.

Published
2012

10. Optimizing the design of web-based questionnaires – experience from a population-based study among 50,000 women.

Author

Alexandra Ekman, Åsa Klint, Paul Dickman, Hans-Olov Adami, and Jan-Eric Litton

Subjects
INTERNET questionnaires, EPIDEMIOLOGICAL research, SOCIODEMOGRAPHIC factors, RESPONSE rates
Abstract

Abstract Background  Web-questionnaires are an important tool for future epidemiological research because these allow for rapid and cost-efficient assembly of self-reported information on risk factors and health outcomes. However, to achieve high response rates it is essential to accommodate factors that prevent drop out and so insure validity of future studies. We aim to study how socio-demographic variables as well as design issues such as the ordering and level of difficulty (Easy-to-hard vs. Hard-to-easy) of questions in a web-questionnaire affects the probability of drop out and non-response. Method  In 2003 we invited 47,859 women participating in an ongoing prospective study to a follow-up using a web-based mode. Two versions of the questionnaire existed, varying in level of difficulty (Easy-to-hard vs. Hard-to-easy). We report drop out (proportion non-completers) between groups defined by level of difficulty and estimated adjusted risk differences. Results  The drop out differs significantly depending on the order of the questions in the web-questionnaire. The socio-demographic pattern among lurkers (participants that enter, start responding to, but do not complete a web-questionnaire) differs from that among completers of web-questionnaires. Conclusions  An additional 6% units of completers – persons initiating and completing the questionnaire – can be obtained by considering the ordering of questions. A group uniquely identified in web-surveys,␣as lurkers are potentially easier to persuade to complete an already started web-questionnaire compared to a non-responder. Lurkers thus constitute a unique opportunity of decreasing the drop out rate and therefore merit future research. [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

11. Feasibility of Using Web-based Questionnaires in Large Population-based Epidemiological Studies.

Author

Alexandra Ekman, Paul Dickman, Åsa Klint, Elisabete Weiderpass, and Jan-Eric Litton

Abstract

To date, few large web-based epidemiological studies have been performed in a population-based setting. Sweden has optimal prerequisites for web-based studies with more than 80% of the general population having access to the Internet. Our aim was to investigate (I) response rates in an epidemiological study using primarily the web as a tool for data collection and (II) whether socio-demographic patterns vary between responders to a web and a paper questionnaire. In 2003, we invited 47,859 women to complete a web questionnaire. Two reminders were sent to non-responders; in the first a random sample received a paper questionnaire and in the second the majority received a paper questionnaire. All other non-responders received web questionnaires. Differences in response rates between responders to web and paper questionnaires with regard to socio-demographic and other variables were analyzed, and estimates of the bias introduced by these differences were estimated. In total, 41% of the women responded to the web questionnaire and 31% to the paper questionnaire (overall response rate 72%). The web-, paper- and non-responders respectively did not differ significantly in age, physical activity levels, and body mass index. Women answering web or paper questionnaires had a higher level of education and income and a lower level of smoking than non-responders. The bias associated with collecting information using web questionnaires was not greater than that caused by paper questionnaires. We conclude that web-based questionnaires are a feasible tool for data collection in large population based epidemiological studies in Sweden. [ABSTRACT FROM AUTHOR]

Published
2006
Full Text
View/download PDF

13. Gonadoblastoma

Author

Blair Reuben, Paul Dickman, Martin Koyle, and Jacob Rajfer

Subjects
Pediatrics, Perinatology and Child Health, General Medicine, Pathology and Forensic Medicine
Published
1987
Full Text
View/download PDF

17. Differences in management of older women influence breast cancer survival: results from a population-based database in Sweden

Author

Eaker, S., Paul Dickman, Bergkvist, L., Holmberg, L., and Uppsala/Orebro Breast Cancer Group

Subjects
Gynecology, Geriatrics, medicine.medical_specialty, education.field_of_study, Relative survival, business.industry, medicine.medical_treatment, Population, General Medicine, medicine.disease, Radiation therapy, Breast cancer, Internal medicine, medicine, Medicine, Stage (cooking), Breast carcinoma, business, education, Survival analysis
Abstract

BackgroundSeveral reports have shown that less aggressive patterns of diagnostic activity and care are provided to elderly breast carcinoma patients. We sought to investigate whether differences in the management of older women with breast cancer are associated with survival.Methods and findingsIn an observational study using a population-based clinical breast cancer register of one health-care region in Sweden, we identified 9,059 women aged 50-84 y diagnosed with primary breast cancer between 1992 and 2002. The 5-y relative survival ratio was estimated for patients classified by age group, diagnostic activity, tumor characteristics, and treatment. The 5-y relative survival for breast cancer patients was lower (up to 13%) in women 70-84 y of age compared to women aged 50-69 y, and the difference was most pronounced in stage IIB-III and in the unstaged. Significant differences in disease management were found, as older women had larger tumors, had fewer nodes examined, and did not receive treatment by radiotherapy or by chemotherapy as often as the younger women. Adjustment for diagnostic activity, tumor characteristics, and treatment diminished the relative excess mortality in stages III and in the unstaged, whereas the excess mortality was only marginally affected in stage IIB.ConclusionsLess diagnostic activity, less aggressive treatment, and later diagnosis in older women are associated with poorer survival. The large differences in treatment of older women are difficult to explain by co-morbidity alone.

Catalog

Books, media, physical & digital resources
See catalog results