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1. BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability

Author

Silva, Maria P., Ferreira, Luísa T., Brás, Natércia F., Torres, Lurdes, Brandão, Andreia, Pinheiro, Manuela, Cardoso, Marta, Resende, Adriana, Vieira, Joana, Palmeira, Carlos, Martins, Gabriela, Silva, Miguel, Pinto, Carla, Peixoto, Ana, Silva, João, Henrique, Rui, Maia, Sofia, Maiato, Helder, Teixeira, Manuel R., and Paulo, Paula

Published
2024
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2. Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene

Author

Cardoso, Marta, Maia, Sofia, Brandão, Andreia, Sahasrabudhe, Ruta, Lott, Paul, Belter, Natalia, Carvajal-Carmona, Luis G, Paulo, Paula, and Teixeira, Manuel R

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Prostate Cancer, Genetics, Clinical Research, Human Genome, Cancer, Genetic Testing, Urologic Diseases, Aging, 2.1 Biological and endogenous factors, Aetiology, Humans, Male, Exome Sequencing, Genetic Predisposition to Disease, Germ-Line Mutation, Prostatic Neoplasms, Transcription Factors, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundProstate cancer (PrCa) is one of the most hereditable human cancers, however, only a small fraction of patients has been shown to carry deleterious variants in known cancer predisposition genes.MethodsWhole-exome sequencing was performed in multiple affected members of 45 PrCa families to select the best candidate genes behind part of the PrCa missing hereditability. Recurrently mutated genes were prioritised, and further investigated by targeted next-generation sequencing in the whole early-onset and/or familial PrCa series of 462 patients.ResultsPRUNE2 stood out from our analysis when also considering the available data on its association with PrCa development. Ten germline pathogenic/likely pathogenic variants in the PRUNE2 gene were identified in 13 patients. The most frequent variant was found in three unrelated patients and identical-by-descent analysis revealed that the haplotype associated with the variant is shared by all the variant carriers, supporting the existence of a common ancestor.DiscussionThis is the first report of pathogenic/likely pathogenic germline variants in PRUNE2 in PrCa patients, namely in those with early-onset/familial disease. Importantly, PRUNE2 was the most frequently mutated gene in the whole series, with a deleterious germline variant identified in 2.8% of the patients, representing a novel prostate cancer predisposition gene.

Published
2023

3. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Author

Wang, Anqi, Shen, Jiayi, Rodriguez, Alex A., Saunders, Edward J., Chen, Fei, Janivara, Rohini, Darst, Burcu F., Sheng, Xin, Xu, Yili, Chou, Alisha J., Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Plym, Anna, Sahimi, Ali, Hoffman, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Laisk, Triin, Figuerêdo, Jéssica, Muir, Kenneth, Ito, Shuji, Liu, Xiaoxi, Uchio, Yuji, Kubo, Michiaki, Kamatani, Yoichiro, Lophatananon, Artitaya, Wan, Peggy, Andrews, Caroline, Lori, Adriana, Choudhury, Parichoy P., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Rentsch, Christopher T., Cho, Kelly, Mcmahon, Benjamin H., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Borge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Andreas, Stroomberg, Hein V., Batra, Jyotsna, Chambers, Suzanne, Horvath, Lisa, Clements, Judith A., Tilly, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordstrom, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie, Cook, Michael B., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Koutros, Stella, Beane Freeman, Laura E., Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Butler, Ebonee N., Mohler, James L., Taylor, Jack A., Kogevinas, Manolis, Dierssen-Sotos, Trinidad, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Pilie, Patrick, Yu, Yao, Bohlender, Ryan J., Gu, Jian, Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Brenner, Hermann, Chen, Xuechen, Holleczek, Bernd, Schöttker, Ben, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine M., Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Abraham, Aswin, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer, Petrovics, Gyorgy, Casey, Graham, Wang, Ying, Tettey, Yao, Lachance, Joseph, Tang, Wei, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Yamoah, Kosj, Govindasami, Koveela, Chokkalingam, Anand P., Keaton, Jacob M., Hellwege, Jacklyn N., Clark, Peter E., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Ogunbiyi, Olufemi, Shittu, Olayiwola, Amodu, Olukemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Ajibola, Hafees O., Jamda, Mustapha A., Oluwole, Olabode P., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Diop, Halimatou, Gundell, Susan M., Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Kachuri, Linda, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Preuss, Michael H., Loos, Ruth J. F., Zawistowski, Matthew, Zöllner, Sebastian, Lu, Zeyun, Van Den Eeden, Stephen K., Easton, Douglas F., Ambs, Stefan, Edwards, Todd L., Mägi, Reedik, Rebbeck, Timothy R., Fritsche, Lars, Chanock, Stephen J., Berndt, Sonja I., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Gaziano, J. Michael, Justice, Amy C., Mancuso, Nick, Terao, Chikashi, Eeles, Rosalind A., Kote-Jarai, Zsofia, Madduri, Ravi K., Conti, David V., and Haiman, Christopher A.

Published
2023
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9. The effect of sample size on polygenic hazard models for prostate cancer

Author

Karunamuni, Roshan A, Huynh-Le, Minh-Phuong, Fan, Chun C, Eeles, Rosalind A, Easton, Douglas F, Kote-Jarai, ZSofia, Amin Al Olama, Ali, Benlloch Garcia, Sara, Muir, Kenneth, Gronberg, Henrik, Wiklund, Fredrik, Aly, Markus, Schleutker, Johanna, Sipeky, Csilla, Tammela, Teuvo LJ, Nordestgaard, Børge G, Key, Tim J, Travis, Ruth C, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Pharoah, Paul, Pashayan, Nora, Khaw, Kay-Tee, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S, Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa, Brenner, Hermann, Schöttker, Ben, Holleczek, Bernd, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Clements, Judith A, Spurdle, Amanda, Teixeira, Manuel R, Paulo, Paula, Maia, Sofia, Pandha, Hardev, Michael, Agnieszka, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, and Seibert, Tyler M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prostate Cancer, Cancer, Aging, Urologic Diseases, Clinical Trials as Topic, Genome-Wide Association Study, Humans, Male, Models, Genetic, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Proportional Hazards Models, Prostatic Neoplasms, Sample Size, Australian Prostate Cancer BioResource, PRACTICAL Consortium, Genetics, Clinical Sciences, Genetics & Heredity, Clinical sciences
Abstract

We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training and testing sets. Established-SNP models considered 65 SNPs that had been previously associated with prostate cancer. Discovery-SNP models used stepwise selection to identify new SNPs. The performance of each PHS model was calculated for random sizes of the training set. The performance of a representative Established-SNP model was estimated for random sizes of the testing set. Mean HR98/50 (hazard ratio of top 2% to average in test set) of the Established-SNP model increased from 1.73 [95% CI: 1.69-1.77] to 2.41 [2.40-2.43] when the number of training samples was increased from 1 thousand to 30 thousand. Corresponding HR98/50 of the Discovery-SNP model increased from 1.05 [0.93-1.18] to 2.19 [2.16-2.23]. HR98/50 of a representative Established-SNP model using testing set sample sizes of 0.6 thousand and 6 thousand observations were 1.78 [1.70-1.85] and 1.73 [1.71-1.76], respectively. We estimate that a study population of 20 thousand men is required to develop Discovery-SNP PHS models while 10 thousand men should be sufficient for Established-SNP models.

Published
2020

10. A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data

Author

Huynh-Le, Minh-Phuong, Fan, Chun Chieh, Karunamuni, Roshan, Walsh, Eleanor I, Turner, Emma L, Lane, J Athene, Martin, Richard M, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Parsons, J Kellogg, Eeles, Rosalind A, Easton, Douglas F, Kote-Jarai, Zsofia, Al Olama, Ali Amin, Garcia, Sara Benlloch, Muir, Kenneth, Grönberg, Henrik, Wiklund, Fredrik, Aly, Markus, Schleutker, Johanna, Sipeky, Csilla, Tammela, Teuvo LJ, Nordestgaard, Børge Grønne, Key, Timothy J, Travis, Ruth C, Pharoah, Paul DP, Pashayan, Nora, Khaw, Kay-Tee, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S, Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa A, Brenner, Hermann, Schöttker, Ben, Holleczek, Bernd, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Slavov, Chavdar Kroumov, Kaneva, Radka P, Mitev, Vanio I, Batra, Jyotsna, Clements, Judith A, Spurdle, Amanda B, BioResource, for the Australian Prostate Cancer, Teixeira, Manuel R, Paulo, Paula, Maia, Sofia, Pandha, Hardev, Michael, Agnieszka, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, Seibert, Tyler M, and Consortium, for the PRACTICAL

Subjects
Biomedical and Clinical Sciences, Health Sciences, Clinical Sciences, Oncology and Carcinogenesis, Aging, Prostate Cancer, Cancer, Prevention, Urologic Diseases, Good Health and Well Being, Aged, Early Detection of Cancer, Humans, Male, Middle Aged, Neoplasm Grading, Population Control, Prostatic Neoplasms, Australian Prostate Cancer BioResource, PRACTICAL Consortium, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundA polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. Here, we assess the potential impact of PHS-informed screening.MethodsUnited Kingdom population incidence data (Cancer Research United Kingdom) and data from the Cluster Randomized Trial of PSA Testing for Prostate Cancer were combined to estimate age-specific clinically significant prostate cancer incidence (Gleason score ≥7, stage T3-T4, PSA ≥10, or nodal/distant metastases). Using HRs estimated from the ProtecT prostate cancer trial, age-specific incidence rates were calculated for various PHS risk percentiles. Risk-equivalent age, when someone with a given PHS percentile has prostate cancer risk equivalent to an average 50-year-old man (50-year-standard risk), was derived from PHS and incidence data. Positive predictive value (PPV) of PSA testing for clinically significant prostate cancer was calculated using PHS-adjusted age groups.ResultsThe expected age at diagnosis of clinically significant prostate cancer differs by 19 years between the 1st and 99th PHS percentiles: men with PHS in the 1st and 99th percentiles reach the 50-year-standard risk level at ages 60 and 41, respectively. PPV of PSA was higher for men with higher PHS-adjusted age.ConclusionsPHS provides individualized estimates of risk-equivalent age for clinically significant prostate cancer. Screening initiation could be adjusted by a man's PHS.ImpactPersonalized genetic risk assessments could inform prostate cancer screening decisions.

Published
2020

11. Partner-based HIV treatment for seroconcordant couples attending antenatal and postnatal care in rural Mozambique: A cluster randomized controlled trial

Author

Audet, Carolyn M., primary, Graves, Erin, additional, Shepherd, Bryan E., additional, Prigmore, Heather L., additional, Brooks, Hannah L., additional, Emílio, Almiro, additional, Matino, Ariano, additional, Paulo, Paula, additional, Diemer, Matthew A., additional, Frisby, Michael, additional, Sack, Daniel E., additional, Aboobacar, Arifo, additional, Barreto, Ezequiel, additional, Van Rompaey, Sara, additional, and De Schacht, Caroline, additional

Published
2024
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13. Methane Production from Pretreated Anaerobic Sludge

Author

Scarcelli, Priscila Guenka, Serejo, Mayara Leite, Ruas, Graziele, Akayama, Mateus Nishiyama, Paulo, Paula Loureiro, Boncz, Marc Árpad, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Naddeo, Vincenzo, editor, Choo, Kwang-Ho, editor, and Ksibi, Mohamed, editor

Published
2022
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14. Removal of Clostridium Perfringens and Staphylococcus sp. In Microalgae-Bacterial System: Influence of Microalgae Inoculum and CO2/O2 Addition

Author

Ruas, Graziele, Farias, Sarah Lacerda, dos Reis, Bruno Aquino Bezerra, Serejo, Mayara Leite, Paulo, Paula Loureiro, Boncz, Marc Árpád, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Naddeo, Vincenzo, editor, Choo, Kwang-Ho, editor, and Ksibi, Mohamed, editor

Published
2022
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15. Influence of CO2 Addition and Semi-Continuous Feed Regime on Pathogen Removal—Shaded HRAP

Author

Ruas, Graziele, Farias, Sarah Lacerda, Nantes, Maria Alice, Serejo, Mayara Leite, Paulo, Paula Loureiro, Boncz, Marc Árpad, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Naddeo, Vincenzo, editor, Choo, Kwang-Ho, editor, and Ksibi, Mohamed, editor

Published
2022
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17. Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.

Author

Seibert, Tyler M, Fan, Chun Chieh, Wang, Yunpeng, Zuber, Verena, Karunamuni, Roshan, Parsons, J Kellogg, Eeles, Rosalind A, Easton, Douglas F, Kote-Jarai, ZSofia, Al Olama, Ali Amin, Garcia, Sara Benlloch, Muir, Kenneth, Grönberg, Henrik, Wiklund, Fredrik, Aly, Markus, Schleutker, Johanna, Sipeky, Csilla, Tammela, Teuvo Lj, Nordestgaard, Børge G, Nielsen, Sune F, Weischer, Maren, Bisbjerg, Rasmus, Røder, M Andreas, Iversen, Peter, Key, Tim J, Travis, Ruth C, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Pharoah, Paul, Pashayan, Nora, Khaw, Kay-Tee, Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S, Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa, Brenner, Hermann, Cuk, Katarina, Saum, Kai-Uwe, Park, Jong Y, Sellers, Thomas A, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Clements, Judith A, Spurdle, Amanda, Teixeira, Manuel R, Paulo, Paula, Maia, Sofia, Pandha, Hardev, Michael, Agnieszka, Kierzek, Andrzej, Karow, David S, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, and PRACTICAL Consortium*

Subjects
PRACTICAL Consortium*, Humans, Prostatic Neoplasms, Kallikreins, Prostate-Specific Antigen, Disease-Free Survival, Risk Assessment, Survival Analysis, Cohort Studies, Predictive Value of Tests, Age of Onset, Genotype, Polymorphism, Single Nucleotide, Aged, Middle Aged, European Continental Ancestry Group, Male, Early Detection of Cancer, Outcome Assessment, Health Care, Polymorphism, Single Nucleotide, Outcome Assessment, Health Care, Aging, Urologic Diseases, Cancer, Genetic Testing, Prevention, Prostate Cancer, Genetics, 2.1 Biological and endogenous factors, General & Internal Medicine, Public Health and Health Services, Clinical Sciences
Abstract

ObjectivesTo develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age.DesignAnalysis of genotype, PCa status, and age to select single nucleotide polymorphisms (SNPs) associated with diagnosis. These polymorphisms were incorporated into a survival analysis to estimate their effects on age at diagnosis of aggressive PCa (that is, not eligible for surveillance according to National Comprehensive Cancer Network guidelines; any of Gleason score ≥7, stage T3-T4, PSA (prostate specific antigen) concentration ≥10 ng/L, nodal metastasis, distant metastasis). The resulting polygenic hazard score is an assessment of individual genetic risk. The final model was applied to an independent dataset containing genotype and PSA screening data. The hazard score was calculated for these men to test prediction of survival free from PCa.SettingMultiple institutions that were members of international PRACTICAL consortium.ParticipantsAll consortium participants of European ancestry with known age, PCa status, and quality assured custom (iCOGS) array genotype data. The development dataset comprised 31 747 men; the validation dataset comprised 6411 men.Main outcome measuresPrediction with hazard score of age of onset of aggressive cancer in validation set.ResultsIn the independent validation set, the hazard score calculated from 54 single nucleotide polymorphisms was a highly significant predictor of age at diagnosis of aggressive cancer (z=11.2, P98th centile) were compared with those with average scores (30th-70th centile), the hazard ratio for aggressive cancer was 2.9 (95% confidence interval 2.4 to 3.4). Inclusion of family history in a combined model did not improve prediction of onset of aggressive PCa (P=0.59), and polygenic hazard score performance remained high when family history was accounted for. Additionally, the positive predictive value of PSA screening for aggressive PCa was increased with increasing polygenic hazard score.ConclusionsPolygenic hazard scores can be used for personalised genetic risk estimates that can predict for age at onset of aggressive PCa.

Published
2018

18. Contributors

Author

Ali, Ubhat, primary, Alvarez-Chavez, P. Elizabeth, additional, Avalos-Ramírez, Antonio, additional, Barman, L., additional, Barrales-Fernández, Christell, additional, Bhowmick, G.D., additional, Brar, Kamalpreet Kaur, additional, Brar, Satinder Kaur, additional, Chatterjee, Pritha, additional, Chaudhary, M., additional, Cheela, VR Sankar, additional, Cuprys, Agnieszka, additional, Davoodi, Seyyed Mohammadreza, additional, Dubey, Brajesh K., additional, Fournel, Sébastien, additional, Ghanei, Javad, additional, Ghosal, Partha Sarathi, additional, Godbout, Stéphane, additional, Gupta, Ashok Kumar, additional, Jain, N., additional, Karimi Darvanjooghi, Mohammad Hossein, additional, Khurana, Pratishtha, additional, Kulkarni, Kaivalya, additional, Kumar, Pratik, additional, Larios-Martínez, A. Dalila, additional, Magalhães Filho, Fernando Jorge, additional, Magdouli, Sara, additional, Majumder, Abhradeep, additional, Méndez-Carreto, Carlos, additional, Miri, Saba, additional, Osorio-Gonzalez, Carlos Saul, additional, Paulo, Paula, additional, Pulicharla, Rama, additional, Raja, Waseem, additional, Raza, Hayat, additional, Ruiz-Colorado, Nora, additional, Saini, Rahul, additional, Sandoval-Salas, Fabiola, additional, Sebastian, Joseph, additional, Shu, Xuhan, additional, Talekar, Guruprasad V., additional, and Tiwari, Bikash R., additional

Published
2022
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20. Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study

Author

Karlsson, Questa, Brook, Mark N., Dadaev, Tokhir, Wakerell, Sarah, Saunders, Edward J., Muir, Kenneth, Neal, David E., Giles, Graham G., MacInnis, Robert J., Thibodeau, Stephen N., McDonnell, Shannon K., Cannon-Albright, Lisa, Teixeira, Manuel R., Paulo, Paula, Cardoso, Marta, Huff, Chad, Li, Donghui, Yao, Yu, Scheet, Paul, Permuth, Jennifer B., Stanford, Janet L., Dai, James Y., Ostrander, Elaine A., Cussenot, Olivier, Cancel-Tassin, Géraldine, Hoegel, Josef, Herkommer, Kathleen, Schleutker, Johanna, Tammela, Teuvo L.J., Rathinakannan, Venkat, Sipeky, Csilla, Wiklund, Fredrik, Grönberg, Henrik, Aly, Markus, Isaacs, William B., Dickinson, Jo L., FitzGerald, Liesel M., Chua, Melvin L.K., Nguyen-Dumont, Tu, Schaid, Daniel J., Southey, Melissa C., Eeles, Rosalind A., and Kote-Jarai, Zsofia

Published
2021
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24. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Author

Conti, David V., Darst, Burcu F., Moss, Lilit C., Saunders, Edward J., Sheng, Xin, Chou, Alisha, Schumacher, Fredrick R., Olama, Ali Amin Al, Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Sahimi, Ali, Hoffmann, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Muir, Kenneth, Lophatananon, Artitaya, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne R., Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokołorczyk, Dominika, Lubiński, Jan, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Børge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Martin Andreas, Iversen, Peter, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Horvath, Lisa, Clements, Judith A., Tilley, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordström, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie J., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Geybels, Milan S., Koutros, Stella, Freeman, Laura E. Beane, Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Burnet, Neil, Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Fontham, Elizabeth T. H., Mohler, James, Taylor, Jack A., Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Weaver, Brandi, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Saum, Kai-Uwe, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine, Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer C., Petrovics, Gyorgy, Casey, Graham, Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Mancuso, Nicholas, Berndt, Sonja I., Van Den Eeden, Stephen K., Easton, Douglas F., Chanock, Stephen J., Cook, Michael B., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Eeles, Rosalind A., Kote-Jarai, Zsofia, and Haiman, Christopher A.

Published
2021
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25. HIV self-test performance evaluation among priority populations in rural Mozambique: Results from a community-based observational study.

Author

De Schacht, Caroline, Lucas, Carlota, Paulo, Paula, Naftal Fernando, Anibal, Ernesto Chinai, Jalilo, Silva, Wilson P., Amane, Guita, Sultane, Thebora, Honwana, Nely, Malimane, Inacio, Couto, Aleny, Yu, Zhihong, and Wester, C. William

Subjects
RURAL population, YOUNG adults, HIV testing kits, CONVENIENCE sampling (Statistics), PATIENT self-monitoring, SCIENTIFIC observation
Abstract

Background: In 2021, Mozambique initiated community-based oral HIV self-testing (HIVST) to increase testing access and uptake among priority groups, including adult males, adolescents, and young adults. Within an HIVST pilot project, we conducted a performance evaluation assessing participants' ability to successfully conduct HIVST procedures and interpret results. Methods: A cross-sectional study was performed between February-March 2021 among employees, students (18–24 years of age), and community members, using convenience sampling, in two rural districts of Zambézia Province, Mozambique. We quantified how well untrained users performed procedures for the oral HIVST (Oraquick®) through direct observation using a structured checklist, from which we calculated an HIVST usability index (scores ranging 0–100%). Additionally, participants interpreted three previously processed anonymous HIVST results. False reactive and false non-reactive interpretation results were presented as proportions. Bivariate analysis was conducted using Chi-square and Fisher exact tests. Results: A total of 312 persons participated (131[42%] community members, 71[23%] students, 110[35%] employees); 239 (77%) were male; the mean age was 28 years (standard deviation 10). Average usability index scores were 80% among employees, 86% among students, and 77% among community members. Main procedural errors observed included "incorrect tube positioning" (49%), "incorrect specimen collection" (43%), and "improper waiting time for result interpretation" (42%). From the presented anonymous HIVST results, 75% (n = 234) correctly interpreted all three results, while 9 (3%) of study participants failed to correctly interpret any results. Overall, 36 (12%) gave a false non-reactive result interpretation, 21 (7%) a false reactive result interpretation, and 14 (4%) gave both false non-reactive and false reactive result interpretations. Community members generally had lower performance. Conclusions: Despite some observed testing procedural errors, most users could successfully perform an HIVST. Educational sessions at strategic places (e.g., schools, workplaces), and support via social media and hotlines, may improve HIVST performance quality, reducing the risk of incorrect interpretation. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Understanding of medical students regarding the clinical scope of the plastic surgery specialty

Author

Pedro Freire Guerra Boldrin, Júlia Alves Nascimento Rodrigues, Laíne Ribeiro Antonelli, Maria Luísa Peres Vilela, Giovana Alcino Carneiro, and Paulo Paula Piccolo

Subjects
medical students, plastic surgery, understanding, medicine, knowledge, Surgery, RD1-811
Abstract

Introduction: Plastic surgery is popularly known for its performance in body aesthetics. Besides, it includes burns, microsurgery, hand and craniomaxillofacial surgery. Due to the diversity of medical specialties, many of the procedures in which plastic surgeons are trained are also performed by other specialists, which may justify the population's lack of knowledge regarding the rich plastic work. The objective is to understand the Brazilian medical students' comprehension of the plastic surgery clinical scope. Methods: Cross-sectional study, applying an online questionnaire with Google Docs platform using the inclusion criteria of being a medical student and over eighteen years old. It consisted of twelve clinical cases sent to participants through social networks. At the end of 99 days after the link's release, the questionnaire was closed, and the answers were counted with Windows Excel. Results: Sample composed of 423 participants, with a female majority and an average age of 22.23 years, with a higher prevalence of the third year of the academic clinical cycle. It was noticed that students are familiar with plastic surgeons' actions in the aesthetic field, breast reconstruction after carcinoma, and reparative treatment of burns. Academics poorly indicated the treatment of fractures in the craniomaxillofacial complex and the palmar tendons' laceration approach. Conclusion: Students have a good understanding of the role of plastic surgeons in the aesthetic field.

Published
2020
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28. Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

Author

Gusev, Alexander, Shi, Huwenbo, Kichaev, Gleb, Pomerantz, Mark, Li, Fugen, Long, Henry W, Ingles, Sue A, Kittles, Rick A, Strom, Sara S, Rybicki, Benjamin A, Nemesure, Barbara, Isaacs, William B, Zheng, Wei, Pettaway, Curtis A, Yeboah, Edward D, Tettey, Yao, Biritwum, Richard B, Adjei, Andrew A, Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P, John, Esther M, Murphy, Adam B, Signorello, Lisa B, Carpten, John, Leske, M Cristina, Wu, Suh-Yuh, Hennis, Anslem JM, Neslund-Dudas, Christine, Hsing, Ann W, Chu, Lisa, Goodman, Phyllis J, Klein, Eric A, Witte, John S, Casey, Graham, Kaggwa, Sam, Cook, Michael B, Stram, Daniel O, Blot, William J, Eeles, Rosalind A, Easton, Douglas, Kote-Jarai, Zsofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham G, Southey, Melissa C, Fitzgerald, Liesel M, Gronberg, Henrik, Wiklund, Fredrik, Aly, Markus, Henderson, Brian E, Schleutker, Johanna, Wahlfors, Tiina, Tammela, Teuvo LJ, Nordestgaard, Børge G, Key, Tim J, Travis, Ruth C, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Pharoah, Paul, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S, Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa, Teerlink, Craig, Brenner, Hermann, Dieffenbach, Aida K, Arndt, Volker, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Spurdle, Amanda, Clements, Judith A, Teixeira, Manuel R, Pandha, Hardev, Michael, Agnieszka, Paulo, Paula, Maia, Sofia, Kierzek, Andrzej, PRACTICAL consortium, Conti, David V, and Albanes, Demetrius

Subjects
PRACTICAL consortium, Cell Line, Tumor, Humans, Prostatic Neoplasms, Genetic Predisposition to Disease, Histones, Epigenesis, Genetic, Acetylation, Inheritance Patterns, Linkage Disequilibrium, Polymorphism, Single Nucleotide, African Americans, European Continental Ancestry Group, Male, Atlases as Topic, Genome-Wide Association Study, Genetic Loci, Cell Line, Tumor, Epigenesis, Genetic, Polymorphism, Single Nucleotide
Abstract

Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.

Published
2016

31. Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer

Author

Peixoto, Andreia, Ferreira, Dylan, Azevedo, Rita, Freitas, Rui, Fernandes, Elisabete, Relvas-Santos, Marta, Gaiteiro, Cristiana, Soares, Janine, Cotton, Sofia, Teixeira, Beatriz, Paulo, Paula, Lima, Luís, Palmeira, Carlos, Martins, Gabriela, Oliveira, Maria José, Silva, André M. N., Santos, Lúcio Lara, and Ferreira, José Alexandre

Published
2021
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32. Wetlands construídos como ecotecnologia para o tratamento de águas residuárias: Experiências brasileiras

Author

Sezerino, Pablo Heleno, primary, Pelissari, Catiane, additional, Silva, Arieleen Reis da, additional, Matos, Mateus Pimentel de, additional, Matos, Antonio Teixeira de, additional, Bassani, Leandro, additional, Decezaro, Samara Terezinha, additional, Silveira, Daniele Damasceno, additional, Trein, Camila Maria, additional, Moraes, Mirene Augusta de Andrade, additional, Sperling, Marcos Von, additional, Filho, Fernando Jorge Correa Magalhães, additional, Paulo, Paula Loureiro, additional, Rodrigues, Eduardo Bello, additional, Kaick, Tamara Simone Van, additional, Araújo, Ronaldo Kanopf de, additional, Colares, Gustavo Stolzenberg, additional, Lutterbeck, Carlos Alexandre, additional, and Machado, Ênio Leandro, additional

Published
2021
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36. Treated domestic effluents for non-potable reuse: microbial risk assessment and economic viability.

Author

da Silva Santos, Luciene, de Simone Souza, Hugo Henrique, Amoah, Isaac Dennis, Magri, Maria Elisa, Nobuyoshi Ide, Carlos, and Loureiro Paulo, Paula

Subjects
SEWAGE, SANITATION, WASTEWATER treatment, NET present value, RISK assessment, WATER reuse
Abstract

In this study, we applied quantitative microbial risk assessment and net present value methodologies to evaluate the economic viability and safety of wastewater treatment to produce water for reuse. We found payback periods of three to over 15 years for investment in the universalisation of sanitation services in the selected municipalities, wherein the most feasible scenarios were those in which water reuse was carried out at its maximum potential. Microbial risk was assessed in terms of reduced concentrations of Escherichia coli. Results show that reuse of wastewater treated by different plant configurations for crop irrigation, involving only secondary treatment processes, presented high risk of infection for both farmers and consumers (3.50E–02 ± 3.10E–03 and 5.80E 02 ± 3.30E–03, respectively). In the urban and industrial context, it did not pose any risk beyond the tolerable risk recommended by WHO, except for the worker's droplet ingestion route of exposure (2.40E–03 ± 3.80E–03). [ABSTRACT FROM AUTHOR]

Published
2024
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38. Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author

Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary

Published
2023
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39. Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author

Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary

Published
2023
Full Text
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40. Supplementary Acknowledgments from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author

Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary

Published
2023
Full Text
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41. Data from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author

Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary

Published
2023
Full Text
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42. Supplementary Grant Support from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author

Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary

Published
2023
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43. Vertical stratification of sand fly diversity in relation to natural infections of Leishmania sp. and blood-meal sources in Jamari National Forest, Rondônia State, Brazil

Author

Leão, Paula de Oliveira, Pereira Júnior, Antonio Marques, de Paulo, Paula Frassinetti Medeiros, Carvalho, Luis Paulo Costa, Souza, Ana Beatriz Nascimento, da Silva, Michelli Santos, Castro, Thaís Santos, Freitas, Moisés Thiago de Souza, Rodrigues, Moreno Magalhães de Souza, Ferreira, Gabriel Eduardo Melim, and Medeiros, Jansen Fernandes

Published
2020
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46. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Author

Schumacher, Fredrick R., Al Olama, Ali Amin, Berndt, Sonja I., Benlloch, Sara, Ahmed, Mahbubl, Saunders, Edward J., Dadaev, Tokhir, Leongamornlert, Daniel, Anokian, Ezequiel, Cieza-Borrella, Clara, Goh, Chee, Brook, Mark N., Sheng, Xin, Fachal, Laura, Dennis, Joe, Tyrer, Jonathan, Muir, Kenneth, Lophatananon, Artitaya, Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr, Ian M., Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Håkansson, Niclas, West, Catharine M. L., Dunning, Alison M., Burnet, Neil, Mucci, Lorelei A., Giovannucci, Edward, Andriole, Gerald L., Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Beane Freeman, Laura E., Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Travis, Ruth C., Key, Tim J., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C., Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., FitzGerald, Liesel M., Kibel, Adam S., Drake, Bettina F., Vega, Ana, Gómez-Caamaño, Antonio, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L., Stampfer, Meir, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Stanford, Janet L., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Ostrander, Elaine A., Geybels, Milan S., Nordestgaard, Børge G., Nielsen, Sune F., Weischer, Maren, Bisbjerg, Rasmus, Røder, Martin Andreas, Iversen, Peter, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Maier, Christiane, Luedeke, Manuel, Schnoeller, Thomas, Kim, Jeri, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Paulo, Paula, Cardoso, Marta, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Lin, Daniel W., Newcomb, Lisa F., Lessel, Davor, Gamulin, Marija, Kulis, Tomislav, Kaneva, Radka, Usmani, Nawaid, Singhal, Sandeep, Slavov, Chavdar, Mitev, Vanio, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, Xu, Jianfeng, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Michael, Agnieszka, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Lindstrom, Sara, Turman, Constance, Ma, Jing, Hunter, David J., Riboli, Elio, Siddiq, Afshan, Canzian, Federico, Kolonel, Laurence N., Le Marchand, Loic, Hoover, Robert N., Machiela, Mitchell J., Cui, Zuxi, Kraft, Peter, Amos, Christopher I., Conti, David V., Easton, Douglas F., Wiklund, Fredrik, Chanock, Stephen J., Henderson, Brian E., Kote-Jarai, Zsofia, Haiman, Christopher A., Eeles, Rosalind A., The Profile Study, Australian Prostate Cancer BioResource (APCB), The IMPACT Study, Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium (BPC3), The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Cancer of the Prostate in Sweden (CAPS), Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), and The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium

Published
2018
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48. Supplementary notes from Genome-Wide Association Study of Prostate Cancer–Specific Survival

Author

Szulkin, Robert, primary, Karlsson, Robert, primary, Whitington, Thomas, primary, Aly, Markus, primary, Gronberg, Henrik, primary, Eeles, Rosalind A., primary, Easton, Douglas F., primary, Kote-Jarai, Zsofia, primary, Al Olama, Ali Amin, primary, Benlloch, Sara, primary, Muir, Kenneth, primary, Giles, Graham G., primary, Southey, Melissa C., primary, FitzGerald, Liesel M., primary, Henderson, Brian E., primary, Schumacher, Fredrick R., primary, Haiman, Christopher A., primary, Sipeky, Csilla, primary, Tammela, Teuvo L.J., primary, Nordestgaard, Børge G., primary, Key, Timothy J., primary, Travis, Ruth C., primary, Neal, David E., primary, Donovan, Jenny L., primary, Hamdy, Freddie C., primary, Pharoah, Paul D.P., primary, Pashayan, Nora, primary, Khaw, Kay-Tee, primary, Stanford, Janet L., primary, Thibodeau, Stephen N., primary, McDonnell, Shannon K., primary, Schaid, Daniel J., primary, Maier, Christiane, primary, Vogel, Walther, primary, Luedeke, Manuel, primary, Herkommer, Kathleen, primary, Kibel, Adam S., primary, Cybulski, Cezary, primary, Lubiński, Jan, primary, Kluźniak, Wojciech, primary, Cannon-Albright, Lisa, primary, Brenner, Hermann, primary, Herrmann, Volker, primary, Holleczek, Bernd, primary, Park, Jong Y., primary, Sellers, Thomas A., primary, Lim, Hui-Yi, primary, Slavov, Chavdar, primary, Kaneva, Radka P., primary, Mitev, Vanio I., primary, Spurdle, Amanda, primary, Teixeira, Manuel R., primary, Paulo, Paula, primary, Maia, Sofia, primary, Pandha, Hardev, primary, Michael, Agnieszka, primary, Kierzek, Andrzej, primary, Batra, Jyotsna, primary, Clements, Judith A., primary, Albanes, Demetrius, primary, Andriole, Gerald L., primary, Berndt, Sonja I., primary, Chanock, Stephen, primary, Gapstur, Susan M., primary, Giovannucci, Edward L., primary, Hunter, David J., primary, Kraft, Peter, primary, Le Marchand, Loic, primary, Ma, Jing, primary, Mondul, Alison M., primary, Penney, Kathryn L., primary, Stampfer, Meir J., primary, Stevens, Victoria L., primary, Weinstein, Stephanie J., primary, Trichopoulou, Antonia, primary, Bueno-de-Mesquita, Bas H., primary, Tjønneland, Anne, primary, Cox, David G., primary, Maehle, Lovise, primary, Schleutker, Johanna, primary, Lindström, Sara, primary, and Wiklund, Fredrik, primary

Published
2023
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49. Data from Genome-Wide Association Study of Prostate Cancer–Specific Survival

Author

Szulkin, Robert, primary, Karlsson, Robert, primary, Whitington, Thomas, primary, Aly, Markus, primary, Gronberg, Henrik, primary, Eeles, Rosalind A., primary, Easton, Douglas F., primary, Kote-Jarai, Zsofia, primary, Al Olama, Ali Amin, primary, Benlloch, Sara, primary, Muir, Kenneth, primary, Giles, Graham G., primary, Southey, Melissa C., primary, FitzGerald, Liesel M., primary, Henderson, Brian E., primary, Schumacher, Fredrick R., primary, Haiman, Christopher A., primary, Sipeky, Csilla, primary, Tammela, Teuvo L.J., primary, Nordestgaard, Børge G., primary, Key, Timothy J., primary, Travis, Ruth C., primary, Neal, David E., primary, Donovan, Jenny L., primary, Hamdy, Freddie C., primary, Pharoah, Paul D.P., primary, Pashayan, Nora, primary, Khaw, Kay-Tee, primary, Stanford, Janet L., primary, Thibodeau, Stephen N., primary, McDonnell, Shannon K., primary, Schaid, Daniel J., primary, Maier, Christiane, primary, Vogel, Walther, primary, Luedeke, Manuel, primary, Herkommer, Kathleen, primary, Kibel, Adam S., primary, Cybulski, Cezary, primary, Lubiński, Jan, primary, Kluźniak, Wojciech, primary, Cannon-Albright, Lisa, primary, Brenner, Hermann, primary, Herrmann, Volker, primary, Holleczek, Bernd, primary, Park, Jong Y., primary, Sellers, Thomas A., primary, Lim, Hui-Yi, primary, Slavov, Chavdar, primary, Kaneva, Radka P., primary, Mitev, Vanio I., primary, Spurdle, Amanda, primary, Teixeira, Manuel R., primary, Paulo, Paula, primary, Maia, Sofia, primary, Pandha, Hardev, primary, Michael, Agnieszka, primary, Kierzek, Andrzej, primary, Batra, Jyotsna, primary, Clements, Judith A., primary, Albanes, Demetrius, primary, Andriole, Gerald L., primary, Berndt, Sonja I., primary, Chanock, Stephen, primary, Gapstur, Susan M., primary, Giovannucci, Edward L., primary, Hunter, David J., primary, Kraft, Peter, primary, Le Marchand, Loic, primary, Ma, Jing, primary, Mondul, Alison M., primary, Penney, Kathryn L., primary, Stampfer, Meir J., primary, Stevens, Victoria L., primary, Weinstein, Stephanie J., primary, Trichopoulou, Antonia, primary, Bueno-de-Mesquita, Bas H., primary, Tjønneland, Anne, primary, Cox, David G., primary, Maehle, Lovise, primary, Schleutker, Johanna, primary, Lindström, Sara, primary, and Wiklund, Fredrik, primary

Published
2023
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