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540 results on '"Pays, Etienne"'

6. The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity

Author

Lecordier, Laurence, Uzureau, Sophie, Vanwalleghem, Gilles, Deleu, Magali, Crowet, Jean-Marc, Barry, Paul, Moran, Barry, Voorheis, Paul, Dumitru, Andra-Cristina, Yamaryo-Botté, Yoshiki, Dieu, Marc, Tebabi, Patricia, Vanhollebeke, Benoit, Lins, Laurence, Botté, Cyrille Y., Alsteens, David, Dufrêne, Yves, Pérez-Morga, David, Nolan, Derek P., and Pays, Etienne

Published
2020
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15. Endocytosis in African Trypanosomes

Author

Nolan, Derek P., Garcia-Salcedo, Jose A., Geuskens, Maurice, Salmon, Didier, Paturiaux-Hanocq, Françoise, Pays, Annette, Tebabi, Patricia, Pays, Etienne, Black, Samuel J., editor, and Seed, J. Richard, editor

Published
2002
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16. Adenylate Cyclases of Trypanosoma brucei Inhibit the Innate Immune Response of the Host

Author

Salmon, Didier, Vanwalleghem, Gilles, Morias, Yannick, Denoeud, Julie, Krumbholz, Carsten, Lhommé, Frédéric, Bachmaier, Sabine, Kador, Markus, Gossmann, Jasmin, Dias, Fernando Braga Stehling, De Muylder, Géraldine, Uzureau, Pierrick, Magez, Stefan, Moser, Muriel, De Baetselier, Patrick, Van Den Abbeele, Jan, Beschin, Alain, Boshart, Michael, and Pays, Etienne

Published
2012
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17. The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection

Author

Pays, Etienne

Subjects
0301 basic medicine, Apolipoprotein L1, Golgi Apparatus, Biochemistry, 0302 clinical medicine, Phosphatidylinositol Phosphates, Neoplasms, State‐Of‐The‐Art Review, Renal Insufficiency, biology, Chemistry, apoptosis, Actomyosin, 3. Good health, Cell biology, Phosphotransferases (Alcohol Group Acceptor), Virus Diseases, 030220 oncology & carcinogenesis, symbols, medicine.symptom, vesicular trafficking, Intracellular, autophagy, Programmed cell death, Biochimie, Inflammation, 03 medical and health sciences, symbols.namesake, Apolipoproteins L, medicine, Animals, Humans, actomyosin organization, Autistic Disorder, Molecular Biology, mitochondrial fission, Autophagy, Autophagosomes, Biologie moléculaire, Cell Biology, Golgi apparatus, Trypanosomiasis, African, 030104 developmental biology, Gene Expression Regulation, Schizophrenia, biology.protein, Calcium, Biologie cellulaire, PI4KB
Abstract

The discovery that apolipoprotein L1 (APOL1) is the trypanolytic factor of human serum raised interest about the function of APOLs, especially following the unexpected finding that in addition to their protective action against sleeping sickness, APOL1 C-terminal variants also cause kidney disease. Based on the analysis of the structure and trypanolytic activity of APOL1, it was proposed that APOLs could function as ion channels of intracellular membranes and be involved in mechanisms triggering programmed cell death. In this review, the recent finding that APOL1 and APOL3 inversely control the synthesis of phosphatidylinositol-4-phosphate (PI(4)P) by the Golgi PI(4)-kinase IIIB (PI4KB) is commented. APOL3 promotes Ca2+-dependent activation of PI4KB, but due to their increased interaction with APOL3, APOL1 C-terminal variants can inactivate APOL3, leading to reduction of Golgi PI(4)P synthesis. The impact of APOLs on several pathological processes that depend on Golgi PI(4)P levels is discussed. I propose that through their effect on PI4KB activity, APOLs control not only actomyosin activities related to vesicular trafficking, but also the generation and elongation of autophagosomes induced by inflammation., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2020

18. Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

Author

Genovese, Giulio, Friedman, David J., Ross, Michael D., Lecordier, Laurence, Uzureau, Pierrick, Freedman, Barry I., Bowden, Donald W., Langefeld, Carl D., Oleksyk, Taras K., Knob, Andrea L. Uscinski, Bernhardy, Andrea J., Hicks, Pamela J., Nelson, George W., Vanhollebeke, Benoit, Winkler, Cheryl A., Kopp, Jeffrey B., Pays, Etienne, and Pollak, Martin R.

Published
2010

28. Mechanism of Trypanosoma brucei gambiense resistance to human serum

Author

Uzureau, Pierrick, Uzureau, Sophie, Lecordier, Laurence, Fontaine, Frederic, Tebabi, Patricia, Homble, Fabrice, Grelard, Axelle, Zhendre, Vanessa, Nolan, Derek P., Lins, Laurence, Crowet, Jean-Marc, Pays, Annette, Felu, Cecile, Poelvoorde, Philippe, Vanhollebeke, Benoit, Moestrup, Soren K., Lyngso, Jeppe, Pedersen, Jan Skov, Mottram, Jeremy C., Dufoure, Erick J., Perez-Morga, David, and Pays, Etienne

Subjects
Lipid membranes -- Physiological aspects, Serum -- Properties, Trypanosoma brucei -- Properties, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The African parasite Trypanosoma bruceigambiense accounts for 97% of human sleeping sickness cases (1). T. b. gambiense resists the specific human innate immunity acting against several other tsetse-fly-transmitted trypanosome species such as T. b. brucei, the causative agent of nagana disease in cattle. Human immunity to some African trypanosomes is due to two serum complexes designated trypanolytic factors (TLF-1 and -2), which both contain haptoglobin-related protein (HPR) and apolipoprotein LI (APOL1) (2-4). Whereas HPR association with haemoglobin (Hb) allows TLF-1 binding and uptake via the trypanosome receptor TbHpHbR (ref. 5), TLF-2 enters trypanosomes independently of TbHpHbR (refs 4, 5). APOL1 kills trypanosomes after insertion into endosomal/lysosomal membranes (2,6,7). Here we report that T. b. gambiense resists TLFs via a hydrophobic β-sheet of the T. b. gambiense-specific glycoprotein (TgsGP) (8), which prevents APOL1 toxicity and induces stiffening of membranes upon interaction with lipids. Two additional features contribute to resistance to TLFs: reduction of sensitivity to APOL1 requiring cysteine protease activity, and TbHpHbR inactivation due to a L210S substitution. According to such a multifactorial defence mechanism, transgenic expression of T. b. brucei TbHpHbR in T. b. gambiense did not cause parasite lysis in normal human serum. However, these transgenic parasites were killed in hypohaptoglobinaemic serum, after high TLF-1 uptake in the absence of haptoglobin (Hp) that competes for Hb and receptor binding. TbHpHbR inactivation preventing high APOL1 loading in hypohaptoglobinaemic serum may have evolved because of the overlapping endemic area of T.b. gambiense infection and malaria, the main cause of haemolysis-induced hypohaptoglobinaemia in western and central Africa (9)., The protozoan flagellate Trypanosoma brucei brucei infects many mammals, except some primates including humans, where it is lysed by the trypanolytic protein APOL1 (refs 2, 6, 7). APOL1 is associated [...]

Published
2013

30. Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I

Author

Vanhollebeke, Benoit, Truc, Philippe, Joshi, Prashant P., Katti, Ravindra, Poelvoorde, Philippe, Pays, Annette, Jannin, Jean G., and Pays, Etienne

Subjects
Trypanosoma -- Development and progression, Trypanosoma -- Risk factors, India -- Health aspects
Abstract

Humans have innate immunity against Trypanosoma brucei brucei that is known to involve apolipoprotein L-I (APOL1), but a case of T. evansi infection in a human was identified in India. The serum of the infected patient was found to have no trypanolytic activity, a finding linked to the lack of APOL1, and activity was restored by the addition of recombinant APOL1.

Published
2006

31. Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor

Author

Baral, Toya Nath, Magez, Stefan, Stijlemans, Benoit, Conrath, Katja, Vanhollebeke, Benoit, Pays, Etienne, Muyldermans, Serge, and De Baetselier, Patrick

Abstract

Author(s): Toya Nath Baral (corresponding author) [1]; Stefan Magez [1]; Benoit Stijlemans [1]; Katja Conrath [1]; Benoit Vanhollebeke [2]; Etienne Pays [2]; Serge Muyldermans [1]; Patrick De Baetselier [1] High [...]

Published
2006
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33. Apolipoprotein L-I is the trypanosome lytic factor of human serum

Author

Vanhamme, Luc, Paturiaux-Hanocq, Francoise, Poelvoorde, Philippe, Nolan, Derek P., Lins, Laurence, Van Den Abbeele, Jan, Pays, Annette, Tebabi, Patricia, Van Xong, Huang, Jacquet, Alain, Moguilevsky, Nicole, Dieu, Marc, Kane, John P., De Baetselier, Patrick, Brasseur, Robert, and Pays, Etienne

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Luc Vanhamme [1, 2]; Françoise Paturiaux-Hanocq [1, 2]; Philippe Poelvoorde [1, 2]; Derek P. Nolan [1, 3]; Laurence Lins [4]; Jan Van Den Abbeele [5]; Annette Pays [1]; Patricia [...]

Published
2003
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37. APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

Author

Uzureau, Sophie, primary, Lecordier, Laurence, additional, Uzureau, Pierrick, additional, Hennig, Dorle, additional, Graversen, Jonas H., additional, Homblé, Fabrice, additional, Mfutu, Pepe Ekulu, additional, Oliveira Arcolino, Fanny, additional, Ramos, Ana Raquel, additional, La Rovere, Rita M., additional, Luyten, Tomas, additional, Vermeersch, Marjorie, additional, Tebabi, Patricia, additional, Dieu, Marc, additional, Cuypers, Bart, additional, Deborggraeve, Stijn, additional, Rabant, Marion, additional, Legendre, Christophe, additional, Moestrup, Søren K., additional, Levtchenko, Elena, additional, Bultynck, Geert, additional, Erneux, Christophe, additional, Pérez-Morga, David, additional, and Pays, Etienne, additional

Published
2020
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40. A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense

Author

Xong, Hoang Van, Vanhamme, Luc, Chamekh, Mustapha, Chimfwembe, Chibeka Evelyn, Abbeele, Jan van den, Pays, Annette, Meirvenne, Nestor van, Hamers, Raymond, Baetselier, Patrick de, and Pays, Etienne

Subjects
Drug resistance in microorganisms -- Genetic aspects, Trypanosoma brucei -- Genetic aspects, Genetic transcription -- Research, Gene expression -- Research, Serum -- Research, Biological sciences
Abstract

A study was performed to demonstrate that the serum-resistance-associated (SRA) gene is an expression site-associated gene of the Edinburgh trypanozoon antigen type 1.10 (ETat 1.10) expression site. The SRA gene was encoded a variant surface glycoprotein-like protein and was only present in the R clones of the ETat strain of the Trypanosoma brucei rhodesiense resistant to normal human serum. Results revealed that SRA resulted to the resistance of the organism against normal human serum.

Published
1998

45. Specific uptake of tumor necrosis factor-alpha is involved in growth control of Trypanosoma brucei

Author

Magez, Stefan, Geuskens, Maurice, Beschin, Alain, del Favero, Herwig, Verschueren, Hendrik, Lucas, Ralf, Pays, Etienne, and de Baetselier, Patrick

Subjects
Trypanosoma brucei -- Research, Tumor necrosis factor -- Analysis, Cytokines -- Physiological aspects, Biological sciences
Abstract

The role of the cytokine tumor-necrosis factor-alpha (TNF-alpha) on the growth regulation of Trypanosoma brucei was determined. TNF-alpha was found to directly interact with T. brucei through a lectin-like domain mapped at the upper side of the TNF molecule which binds to the flagellar pocket. After binding, TNF-alpha are endocytosed and directed to lysosome-like vacuoles to begin lysis. Regulation was manifested by the lytic activity induced by TNF-alpha on the trypanosome during the peak of parasitaemia.

Published
1997

48. Control of gene expression in trypanosomes

Author

Vanhamme, Luc and Pays, Etienne

Subjects
Trypanosoma -- Research, Gene expression -- Research, Parasitic diseases -- Research, Genetic translation -- Research, Biological sciences
Abstract

The action of trypanosomes as carriers of parasitic diseases such as Chagas' disease and the African sleeping sickness operate primarily at posttranscriptional levels during their parasitic life cycle. Protein-coding genes are transcribed into mature mRNAs, or intergenic sequences, in the form of long polycistronic sequences. The untranslated sequences accumulates and promotes the expression of major surface antigens of trypanosomes such as procyclin in insects and variant surface glycoprotein in humans. DNA rearrangements result to antigenic variation and leads to development of the disease.

Published
1995

49. A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei

Author

Salmon, Didier, Geuskens, Maurice, Hanocq, Francoise, Hanocq-Quertier, Jacqueline, Nolan, Derek, Ruben, Larry, and Pays, Etienne

Subjects
Transferrin -- Physiological aspects, Glycoproteins -- Physiological aspects, Trypanosoma brucei -- Research, Biological sciences
Abstract

A heterodimer of the products of ESAG-6 and ESAG-7 mediates the binding and utilization of transferrin (Tf) through bloodstream forms of the transferrin binding protein in T. brucei. Tf binding to the heterodimer occurs at similar orientations of the two subunits and results by simultaneous expression of both subunits in equal amounts, as each subunit homodimerizes when in excess of the other. Each subunit occupies a Tf binding site upon formation of the heterodimer. pESAG-7/6 is the high affinity trypanosomal Tf binding protein.

Published
1994

50. Genetic controls for the expression of surface antigens in African trypanosomes

Author

Pays, Etienne, Vanhamme, Luc, and Berberof, Magali

Subjects
Gene expression -- Research -- Genetic aspects, Parasite antigens -- Research -- Genetic aspects, Antigenic determinants -- Genetic aspects -- Research, Genetic regulation -- Research -- Genetic aspects, Trypanosoma -- Genetic aspects -- Research, Biological sciences, Research, Genetic aspects
Abstract

INTRODUCTION African trypanosomes are the protozoan parasites responsible for major plagues such as the sleeping sickness disease in humans and the Nagana disease in cattle. These parasites are transmitted to [...]

Published
1994

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