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865 results on '"Pazhenkottil, Aju"'

4. Myocardial Blood Flow Quantification Using Stress Cardiac Magnetic Resonance Improves Detection of Coronary Artery Disease

Author

Wang, Shuo, Kim, Paul, Wang, Haonan, Ng, Ming-Yen, Arai, Andrew E., Singh, Amita, Mushtaq, Saima, Sin, Tsun Hei, Tada, Yuko, Hillier, Elizabeth, Jin, Ruyun, Mariager, Christian Østergaard, Salerno, Michael, Pontone, Gianluca, Urmeneta Ulloa, Javier, Saeed, Ibrahim M., Patel, Hena, Goh, Victor, Madsen, Simon, Kim, Won Yong, Singram Krishnam, Mayil, Martínez de Vega, Vicente, Maceira, Alicia M., Monmeneu, Jose V., Pazhenkottil, Aju P., Amir-Khalili, Alborz, Benovoy, Mitchel, Friedrich, Silke, Janich, Martin A., Friedrich, Matthias G., and Patel, Amit R.

Published
2024
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10. Left ventricular function and volumes from gated [13N]-ammonia positron emission tomography myocardial perfusion imaging: A prospective head-to-head comparison against CMR using a hybrid PET/MR device

Author

Maurer, Alexander, Sustar, Aleksandra, Giannopoulos, Andreas A., Grünig, Hannes, Bakula, Adam, Patriki, Dimitri, von Felten, Elia, Messerli, Michael, Pazhenkottil, Aju P., Gebhard, Catherine, Kaufmann, Philipp A., Buechel, Ronny R., and Fuchs, Tobias A.

Published
2023
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15. Imaging of heart disease in women: review and case presentation

Author

Mikail, Nidaa, Rossi, Alexia, Bengs, Susan, Haider, Achi, Stähli, Barbara E., Portmann, Angela, Imperiale, Alessio, Treyer, Valerie, Meisel, Alexander, Pazhenkottil, Aju P., Messerli, Michael, Regitz-Zagrosek, Vera, Kaufmann, Philipp A., Buechel, Ronny R., and Gebhard, Cathérine

Published
2022
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19. Abstract 16882: Comparison of Regadenoson and Adenosine in First Pass Quantitative Perfusion Cardiovascular Magnetic Resonance in Subjects With Suspected Coronary Microvascular Disease

Author

Rodriguez-Lozano, Patricia, Wang, Shuo, Wang, Haonan, Ng, Ming-Yen, Kim, Paul, Singh, Amita, Mushtaq, Saima, Tsun Hei, Sin, Tada, Yuko, Hillier, Elizabeth, Mariager, Christian Østergaard, Salerno, Michael, Pontone, Gianluca, Urmeneta, Javier, Saeed, Ibrahim M, Patel, Hena, Madsen, Simon, Martinez, Vicente, Maceira, Alicia, Monmeneu, Jose, Pazhenkottil, Aju P, Benovoy, Mitchel, Amir-Khalili, Alborz, Janich, Martin A, Arai, Andrew E, Friedrich, Matthias G, and Patel, Amit R

Published
2023
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20. Abstract 16817: Comparison of Diagnostic Performance of Quantitative Perfusion Stress Myocardial Perfusion Imaging With Cardiac Magnetic Resonance Between Different Vasodilators

Author

Rodriguez-Lozano, Patricia, Wang, Shuo, Wang, Haonan, Ng, Ming-Yen, Kim, Paul, Singh, Amita, Mushtaq, Saima, Tsun Hei, Sin, Tada, Yuko, Hillier, Elizabeth, Østergaard Mariager, Christian, Salerno, Michael, Pontone, Gianluca, Urmeneta, Javier, Saeed, Ibrahim M, Patel, Hena, Martinez, Vicente, Maceira, Alicia, Monmeneu, Jose, Pazhenkottil, Aju P, Benovoy, Mitchel, Amir-Khalili, Alborz, Janich, Martin A, Arai, Andrew E, Friedrich, Matthias G, and Patel, Amit R

Published
2023
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21. Dimensional structure of the Brief Illness Perception Questionnaire and Association with adverse childhood experiences in patients with an implantable cardioverter-defibrillator.

Author

Dörner, Marc, von Känel, Roland, Pazhenkottil, Aju P., Altwegg, Rahel, König, Noelle, Nager, Ladina, Attanasio, Veronica, Guth, Lisa, Zirngast, Sina, Menzi, Anna, Zuccarella-Hackl, Claudia, and Princip, Mary

Subjects
ADVERSE childhood experiences, IMPLANTABLE cardioverter-defibrillators, PATIENT experience, DIMENSIONAL analysis, PATIENTS' attitudes
Abstract

Illness perceptions (IP), as measured by the Brief Illness Perception Questionnaire (BIPQ), and adverse childhood experiences (ACE) have been shown to affect the physical and psychological well-being in different patient populations. However, little is known about IP and ACE in patients with an implantable cardioverter-defibrillator (ICD). Our objectives were to investigate the dimensional structure and to evaluate correlates of the BIPQ in ICD patients. 423 patients with an ICD were prospectively recruited. We conducted a principal component analysis to determine the dimensional structure of the BIPQ. Associations between ACE, other sociodemographic and clinical variables, and IP were analysed using a multivariable linear regression. We identified a two-factor structure (I = Consequences, II = Control) of the BIPQ. Among others, a higher number of ICD shocks in the past (0.21, 95% CI = 0.01–0.41, p = 0.036), low physical activity (-2.16, 95% CI = -4.37 to -0.37, p = 0.045), more frequent ACE (0.56, 95% CI = 0.08–1.22, p = 0.030), ICD shock-related concerns (0.75, 95% CI 0.62–0.89, p < 0.001), and primary ICD indication (-2.29, 95% CI -4.47 to -0.11, p = 0.039) were significantly associated with more threatening IP. The identification of those variables might lead to more precise interventions targeting maladaptive IP in this vulnerable patient population. [ABSTRACT FROM AUTHOR]

Published
2025
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22. Splenic switch-off as a novel marker for adenosine response in nitrogen-13 ammonia PET myocardial perfusion imaging: Cross-validation against CMR using a hybrid PET/MR device

Author

Bakula, Adam, Patriki, Dimitri, von Felten, Elia, Benetos, Georgios, Sustar, Aleksandra, Benz, Dominik C., Wiedemann-Buser, Muriel, Treyer, Valerie, Pazhenkottil, Aju P., Gräni, Christoph, Gebhard, Catherine, Kaufmann, Philipp A., Buechel, Ronny R., and Fuchs, Tobias A.

Published
2022
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34. Relationship between erectile dysfunction and alexithymia in male patients with implantable cardioverter defibrillators: a cross-sectional study.

Author

Ledermann, Katharina, Zuccarella-Hackl, Claudia, Altwegg, Rahel, Dörner, Marc, Attanasio, Veronica, Guth, Lisa, Zirngast, Sina, Pazhenkottil, Aju P., Menzi, Anna, von Känel, Roland, and Princip, Mary

Subjects
SEXUAL excitement, IMPOTENCE, IMPLANTABLE cardioverter-defibrillators, ADJUSTMENT disorders, SELF-expression
Abstract

Background: Implantable Cardioverter-Defibrillator (ICD) implantation is a life-saving intervention for individuals at risk of life-threatening arrhythmias. However, the psychosocial impact of ICD implantation extends beyond its cardiovascular benefits, potentially influencing emotional well-being and sexual health. This can lead to erectile dysfunction, which, is often associated with alexithymia. Both erectile dysfunction and alexithymia can significantly affect the psychological well-being of both patients and their partners. Aims: This study examines the association of erectile dysfunction with alexithymia in patients after ICD implantation. Additionally, we investigate potential moderators of this association. Method: Patients (N=165) completed self-rating questionnaires: Toronto Alexithymia scale (TAS-20), International Index of Erectile Function (IIEF-5), Adjustment disorder – new module (ADNM-20). Descriptive statistics, correlations, multivariate linear regressions, and moderation analysis were conducted. Results: The determinants of erectile dysfunction in ICD patients were explored in a regression model explaining 22% of the total variance. The ADNM-20 subscale preoccupation was found to significantly moderate the relationship between the alexithymia subscale externally oriented thinking and erectile dysfunction (R2 = 0.02, p=0.03). Conclusion: We did not find evidence for a relationship between externally oriented thinking and erectile dysfunction at low to average levels of preoccupation. However, evidence for such a relationship was found at high levels of preoccupation, where more externally oriented thinking was related to more erectile dysfunction. The intersection of alexithymia and erectile dysfunction represents a promising avenue for future research, offering opportunities to unravel the intricate connections between emotional processing and sexual health. Enhancing insights into this relationship could lead to innovative interventions that address the needs of individuals struggling with both conditions, fostering improved emotional expression, intimate relationships, and sexual satisfaction. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Duration of adenosine-induced myocardial hyperaemia: insights from quantitative 13N-ammonia positron emission tomography myocardial perfusion imaging.

Author

Garefa, Chrysoula, Sager, Dominik F, Heiniger, Pascal S, Markendorf, Susanne, Albertini, Tobia, Jurisic, Stjepan, Gajic, Marko, Gebhard, Catherine, Benz, Dominik C, Pazhenkottil, Aju P, Giannopoulos, Andreas A, Kaufmann, Philipp A, Slomka, Piotr J, and Buechel, Ronny R

Subjects
LEFT heart ventricle, DATA analysis, ADENOSINES, CORONARY circulation, MULTIPLE regression analysis, POSITRON emission tomography, RETROSPECTIVE studies, QUANTITATIVE research, DESCRIPTIVE statistics, HEART physiology, MANN Whitney U Test, CHI-squared test, PERFUSION imaging, HYPEREMIA, MEDICAL records, ACQUISITION of data, STATISTICS, PERFUSION, DATA analysis software
Abstract

Aims This study aimed to assess the impact of adenosine on quantitative myocardial blood flow (MBF) in a rapid stress–rest protocol compared with a rest–stress protocol using 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI) and to gain insights into the time dependency of such effects. Methods and results Quantitative MBF at rest (rMBF) and during adenosine-induced stress (sMBF) and myocardial flow reserve (MFR) were obtained from 331 retrospectively identified patients who underwent 13N-ammonia PET MPI for suspected chronic coronary syndrome and who all exhibited no perfusion defects. Of these, 146 (44.1%) underwent a rapid stress–rest protocol with a time interval (Δ t stress–rest) of 20 ± 4 min between adenosine infusion offset and rest imaging, as per clinical routine. The remaining 185 (55.9%) patients underwent a rest–stress protocol and served as the reference. Groups did not differ regarding demographics, risk factors, medication, left ventricular function, and calcium scores. rMBF was significantly higher in the stress–rest vs. the rest–stress group [0.80 (interquartile range 0.66–1.00) vs. 0.70 (0.58–0.83) mL·min−1·g−1, P < 0.001], and, as sMBF was identical between groups [2.52 (2.20–2.96) vs. 2.50 (1.96–3.11), P = 0.347], MFR was significantly lower in the stress–rest group [3.07 (2.43–3.88) vs. 3.50 (2.63–4.10), P = 0.007]. There was a weak correlation between Δ t stress–rest and rMBF (r = −0.259, P = 0.002) and between Δ t stress–rest and MFR (r = 0.163, P = 0.049), and the proportion of patients with abnormally high rMBF was significantly decreasing with increasing Δ t stress–rest. Conclusion Intravenously applied adenosine induces a long-lasting hyperaemic effect on the myocardium. Consequently, rapid stress–rest protocols could lead to an overestimation of rMBF and an underestimation of MFR. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Association between vertebral bone mineral density, myocardial perfusion, and long-term cardiovascular outcomes: A sex-specific analysis

Author

Fiechter, Michael, Bengs, Susan, Roggo, Andrea, Haider, Achi, Marędziak, Monika, Portmann, Angela, Treyer, Valerie, Burger, Irene A., Messerli, Michael, Patriki, Dimitri, von Felten, Elia, Benz, Dominik C., Fuchs, Tobias A., Gräni, Christoph, Pazhenkottil, Aju P., Buechel, Ronny R., Kaufmann, Philipp A., and Gebhard, Catherine

Published
2020
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39. Abstract 14447: Multi-Center Evaluation of Stress Myocardial Blood Flow by Cardiac Magnetic Resonance in Known and Suspected Ischemic Heart Disease: Preliminary Findings From the AQUA-MBF Initiative

Author

Wang, Shuo, Wang, Haonan, Benovoy, Mitchel, Ng, Ming-Yen, Kim, Paul, Singh, Amita, Patel, Hena, Saeed, Ibrahim, Pontone, Gianluca, Mushtaq, Saima, Urmeneta, Javier, Hillier, Elizabeth, Gormsen, Lars C, Laustsen, Christoffer, Janich, Martin A, Salerno, Michael, Hirsch, Alexander, Lubberink, Mark, Maceira, Alicia, Monmeneu, Jose, Pazhenkottil, Aju P, Nagpal, Prashant, Friedrich, Silke, Gutbrod, Joseph, Flournoy, Caroline, Tada, Yuko, Tsun Hei, Sin, Fong, Ambrose Ho Tung, Cheng, Ka Man Carmen, Goh, Victor K, Madsen, Simon, Arai, Andrew E, Friedrich, Matthias G, and Patel, Amit R

Published
2022
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43. Imaging of the brain–heart axis: prognostic value in a European setting

Author

Mikail, Nidaa, primary, Sager, Dominik F, additional, Gebert, Pimrapat, additional, Haider, Ahmed, additional, Todorov, Atanas, additional, Bengs, Susan, additional, Sablonier, Noemi, additional, Glarner, Isabelle, additional, Vinzens, Adriana, additional, Sang Bastian, Nastaran, additional, Epprecht, Gioia, additional, Sütsch, Claudia, additional, Delcò, Alessia, additional, Fiechter, Michael, additional, Portmann, Angela, additional, Treyer, Valerie, additional, Wegener, Susanne, additional, Gräni, Christoph, additional, Pazhenkottil, Aju, additional, Gebhard, Caroline E, additional, Regitz-Zagrosek, Vera, additional, Tanner, Felix C, additional, Kaufmann, Philipp A, additional, Buechel, Ronny R, additional, Rossi, Alexia, additional, and Gebhard, Catherine, additional

Published
2024
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44. Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring

Author

Bengs, Susan, Haider, Achi, Warnock, Geoffrey I., Fiechter, Michael, Pargaetzi, Yves, Rampidis, Georgios, Etter, Dominik, Wijnen, Winandus J., Portmann, Angela, Osto, Elena, Treyer, Valerie, Benz, Dominik C., Meisel, Alexander, Fuchs, Tobias A., Gräni, Christoph, Buechel, Ronny R., Kaufmann, Philipp A., Pazhenkottil, Aju P., and Gebhard, Catherine

Published
2021
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45. Age- and sex-dependent changes of resting amygdalar activity in individuals free of clinical cardiovascular disease: Sexual dimorphism in amygdalar activity

Author

Haider, Achi, Bengs, Susan, Diggelmann, Flavia, Epprecht, Gioia, Etter, Dominik, Beeler, Anna Luisa, Wijnen, Winandus J., Treyer, Valerie, Portmann, Angela, Warnock, Geoffrey I., Grämer, Muriel, Todorov, Atanas, Fuchs, Tobias A., Pazhenkottil, Aju P., Buechel, Ronny R., Tanner, Felix C., Kaufmann, Philipp A., Gebhard, Catherine, and Fiechter, Michael

Published
2021
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46. Comparative diagnostic accuracy of adenosine and regadenoson stress CMR for detecting obstructive coronary artery disease: Insights from the multicenter AQUA study

Author

Lozano, Patricia Rodriguez, Wang, Shuo, Ng, Ming-Yen, Wang, Haonan, Patel, Hena, Mushtaq, Saima, Arai, Andrew A, Saeed, Ibrahim M., Singh, Amita, Kim, Paul J, Salerno, Michael, Sin, Tsun Hei, Hillier, Elizabeth, Mariager, Christian Østergaard, Pontone, Gianluca, Madsen, Simon, Monmeneu, Jose V, Maceira, Alicia M., Tada, Yuko, Pazhenkottil, Aju, Ulloa, Javier Urmeneta, Amir-Khalili, Alborz, Benovoy, Mitchel, Friedrich, Silke, Janich, Martin A., Friedrich, Matthias G., and Patel, Amit R.

Published
2025
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50. Relationship between erectile dysfunction and alexithymia in male patients with implantable cardioverter defibrillators: a cross-sectional study

Author

Ledermann, Katharina; https://orcid.org/0000-0001-9355-2979, Zuccarella-Hackl, Claudia; https://orcid.org/0000-0001-5267-9383, Altwegg, Rahel; https://orcid.org/0009-0005-5142-4270, Dörner, Marc; https://orcid.org/0000-0003-3229-1677, Attanasio, Veronica, Guth, Lisa, Zirngast, Sina, Pazhenkottil, Aju P; https://orcid.org/0000-0002-8847-2154, Menzi, Anna, von Känel, Roland; https://orcid.org/0000-0002-8929-5129, Princip, Mary; https://orcid.org/0000-0002-4937-7605, Ledermann, Katharina; https://orcid.org/0000-0001-9355-2979, Zuccarella-Hackl, Claudia; https://orcid.org/0000-0001-5267-9383, Altwegg, Rahel; https://orcid.org/0009-0005-5142-4270, Dörner, Marc; https://orcid.org/0000-0003-3229-1677, Attanasio, Veronica, Guth, Lisa, Zirngast, Sina, Pazhenkottil, Aju P; https://orcid.org/0000-0002-8847-2154, Menzi, Anna, von Känel, Roland; https://orcid.org/0000-0002-8929-5129, and Princip, Mary; https://orcid.org/0000-0002-4937-7605

Abstract

Background: Implantable Cardioverter-Defibrillator (ICD) implantation is a life-saving intervention for individuals at risk of life-threatening arrhythmias. However, the psychosocial impact of ICD implantation extends beyond its cardiovascular benefits, potentially influencing emotional well-being and sexual health. This can lead to erectile dysfunction, which, is often associated with alexithymia. Both erectile dysfunction and alexithymia can significantly affect the psychological well-being of both patients and their partners. Aims: This study examines the association of erectile dysfunction with alexithymia in patients after ICD implantation. Additionally, we investigate potential moderators of this association. Method: Patients (N=165) completed self-rating questionnaires: Toronto Alexithymia scale (TAS-20), International Index of Erectile Function (IIEF-5), Adjustment disorder – new module (ADNM-20). Descriptive statistics, correlations, multivariate linear regressions, and moderation analysis were conducted. Results: The determinants of erectile dysfunction in ICD patients were explored in a regression model explaining 22% of the total variance. The ADNM-20 subscale preoccupation was found to significantly moderate the relationship between the alexithymia subscale externally oriented thinking and erectile dysfunction (R2 = 0.02, p=0.03). Conclusion: We did not find evidence for a relationship between externally oriented thinking and erectile dysfunction at low to average levels of preoccupation. However, evidence for such a relationship was found at high levels of preoccupation, where more externally oriented thinking was related to more erectile dysfunction. The intersection of alexithymia and erectile dysfunction represents a promising avenue for future research, offering opportunities to unravel the intricate connections between emotional processing and sexual health. Enhancing insights into this relationship could lead to innovative interventions that addr

Published
2024

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