One of the main causes for the scarce use of biofertilizers for the improvement of soils and the increase of productivity, is the insufficient knowledge of farmers about the advantages of its usage at Calixto Garcia municipality, located southwest of Holguin Province. Thus, the objective of this research was to elaborate a program for the knowledge management on biofertilizers, in which synergy and participation, facilitated innovation at a local level for a sustainable farming development, through semi-structured interview with 35 farmers in the CCS (Cooperative of credit and service) "Juan Manuel Romero" and the participative observation for three years of the systematic work in this farm. The synergy and participative program for the knowledge management on the use of biofertilizers was obtained and it contains four stages-: elaboration, planning, execution and control and adjustment; with fifteen phases: understanding of necessities and knowledge opportunities, construction, organization, distribution, application and exploitation of this knowledge by the farmer. The needs of knowledge and the typology of producers were identified, comprised by four groups for the recommendation of activities on agrarian extension. A knowledge map about biofertilizers for the municipality with the main knowledge sources and actors with influence upon the thematic was obtained. [ABSTRACT FROM AUTHOR]