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1. Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

Author

King, Hannah A. D., Joyce, M. Gordon, Lakhal-Naouar, Ines, Ahmed, Aslaa, Cincotta, Camila Macedo, Subra, Caroline, Peachman, Kristina K., Hack, Holly R., Chen, Rita E., Thomas, Paul V., Chen, Wei-Hung, Sankhala, Rajeshwer S., Hajduczki, Agnes, Martinez, Elizabeth J., Peterson, Caroline E., Chang, William C., Choe, Misook, Smith, Clayton, Headley, Jarrett A., Elyard, Hanne A., Cook, Anthony, Anderson, Alexander, Wuertz, Kathryn McGuckin, Dong, Ming, Swafford, Isabella, Case, James B., Currier, Jeffrey R., Lal, Kerri G., Amare, Mihret F., Dussupt, Vincent, Molnar, Sebastian, Daye, Sharon P., Zeng, Xiankun, Barkei, Erica K., Alfson, Kendra, Staples, Hilary M., Carrion, Ricardo, Krebs, Shelly J., Paquin-Proulx, Dominic, Karasavvas, Nicos, Polonis, Victoria R., Jagodzinski, Linda L., Vasan, Sandhya, Scott, Paul T., Huang, Yaoxing, Nair, Manoj S., Ho, David D., de Val, Natalia, Diamond, Michael S., Lewisi, Mark G., Rao, Mangala, Matyas, Gary R., Gromowski, Gregory D., Peel, Sheila A., Michael, Nelson L., Modjarrad, Kayvon, and Bolton, Diane L.

Published
2021

2. Liposome Formulations as Adjuvants for Vaccines

Author

Rao, Mangala, Peachman, Kristina K., Alving, Carl R., Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Malissen, Bernard, Series Editor, Rappuoli, Rino, Series Editor, and Gill, Harvinder Singh, editor

Published
2021
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5. Analytical validation of quantitative SARS-CoV-2 subgenomic and viral load laboratory developed tests conducted on the Panther Fusion® (Hologic) with preliminary application to clinical samples

Author

Lakhal-Naouar, Ines, primary, Hack, Holly R., additional, Moradel, Edgar, additional, Jarra, Amie, additional, Grove, Hannah L., additional, Ismael, Rani M., additional, Padilla, Steven, additional, Coleman, Dante, additional, Ouellette, Jason, additional, Darden, Janice, additional, Storme, Casey, additional, Peachman, Kristina K., additional, Hall, Tara L., additional, Huhtanen, Mark E., additional, Scott, Paul T., additional, Hakre, Shilpa, additional, Jagodzinski, Linda L., additional, and Peel, Sheila A., additional

Published
2023
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8. HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues

Author

Ollerton, Matthew T., primary, Folkvord, Joy M., additional, Peachman, Kristina K., additional, Shashikumar, Soumya, additional, Morrison, Elaine B., additional, Jagodzinski, Linda L., additional, Peel, Sheila A., additional, Khreiss, Mohammad, additional, D’Aquila, Richard T., additional, Casares, Sofia, additional, Rao, Mangala, additional, and Connick, Elizabeth, additional

Published
2022
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9. Validation of SARS-CoV-2 pooled testing for surveillance using the Panther Fusion® system: Impact of pool size, automation, and assay chemistry

Author

Park, Rudolph, primary, Chandrasekaran, Prabha, additional, Hernandez, Heather, additional, Lakhal-Naouar, Ines, additional, Peachman, Kristina K., additional, Hack, Holly R., additional, Coleman, Dante, additional, Ouellette, Jason, additional, Darden, Janice M., additional, M’hamdi, Oussama, additional, Sugiharto, Victor A., additional, Chen, Hua-Wei, additional, Schilling, Megan A., additional, Simons, Mark P., additional, Collins, Natalie D., additional, Johnson, Yuliya S., additional, Jagodzinski, Linda L., additional, and Peel, Sheila A., additional

Published
2022
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10. Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 Infection

Author

Wieczorek, Lindsay, primary, Zemil, Michelle, additional, Merbah, Mélanie, additional, Dussupt, Vincent, additional, Kavusak, Erin, additional, Molnar, Sebastian, additional, Heller, Jonah, additional, Beckman, Bradley, additional, Wollen-Roberts, Suzanne, additional, Peachman, Kristina K., additional, Darden, Janice M., additional, Krebs, Shelly, additional, Rolland, Morgane, additional, Peel, Sheila A., additional, and Polonis, Victoria R., additional

Published
2022
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11. A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine Is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model

Author

Johnston, Sara C., primary, Ricks, Keersten M., additional, Lakhal-Naouar, Ines, additional, Jay, Alexandra, additional, Subra, Caroline, additional, Raymond, Jo Lynne, additional, King, Hannah A. D., additional, Rossi, Franco, additional, Clements, Tamara L., additional, Fetterer, David, additional, Tostenson, Samantha, additional, Cincotta, Camila Macedo, additional, Hack, Holly R., additional, Kuklis, Caitlin, additional, Soman, Sandrine, additional, King, Jocelyn, additional, Peachman, Kristina K., additional, Kim, Dohoon, additional, Chen, Wei-Hung, additional, Sankhala, Rajeshwer S., additional, Martinez, Elizabeth J., additional, Hajduczki, Agnes, additional, Chang, William C., additional, Choe, Misook, additional, Thomas, Paul V., additional, Peterson, Caroline E., additional, Anderson, Alexander, additional, Swafford, Isabella, additional, Currier, Jeffrey R., additional, Paquin-Proulx, Dominic, additional, Jagodzinski, Linda L., additional, Matyas, Gary R., additional, Rao, Mangala, additional, Gromowski, Gregory D., additional, Peel, Sheila A., additional, White, Lauren, additional, Smith, Jeffrey M., additional, Hooper, Jay W., additional, Michael, Nelson L., additional, Modjarrad, Kayvon, additional, Joyce, M. Gordon, additional, Nalca, Aysegul, additional, Bolton, Diane L., additional, and Pitt, Margaret L. M., additional

Published
2022
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12. A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates

Author

Joyce, M. Gordon, primary, King, Hannah A. D., additional, Elakhal-Naouar, Ines, additional, Ahmed, Aslaa, additional, Peachman, Kristina K., additional, Macedo Cincotta, Camila, additional, Subra, Caroline, additional, Chen, Rita E., additional, Thomas, Paul V., additional, Chen, Wei-Hung, additional, Sankhala, Rajeshwer S., additional, Hajduczki, Agnes, additional, Martinez, Elizabeth J., additional, Peterson, Caroline E., additional, Chang, William C., additional, Choe, Misook, additional, Smith, Clayton, additional, Lee, Parker J., additional, Headley, Jarrett A., additional, Taddese, Mekdi G., additional, Elyard, Hanne A., additional, Cook, Anthony, additional, Anderson, Alexander, additional, McGuckin Wuertz, Kathryn, additional, Dong, Ming, additional, Swafford, Isabella, additional, Case, James Brett, additional, Currier, Jeffrey R., additional, Lal, Kerri G., additional, Molnar, Sebastian, additional, Nair, Manoj S., additional, Dussupt, Vincent, additional, Daye, Sharon P., additional, Zeng, Xiankun, additional, Barkei, Erica K., additional, Staples, Hilary M., additional, Alfson, Kendra, additional, Carrion, Ricardo, additional, Krebs, Shelly J., additional, Paquin-Proulx, Dominic, additional, Karasavva, Nicos, additional, Polonis, Victoria R., additional, Jagodzinski, Linda L., additional, Amare, Mihret F., additional, Vasan, Sandhya, additional, Scott, Paul T., additional, Huang, Yaoxing, additional, Ho, David D., additional, de Val, Natalia, additional, Diamond, Michael S., additional, Lewis, Mark G., additional, Rao, Mangala, additional, Matyas, Gary R., additional, Gromowski, Gregory D., additional, Peel, Sheila A., additional, Michael, Nelson L., additional, Bolton, Diane L., additional, and Modjarrad, Kayvon, additional

Published
2022
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13. Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

Author

Bradley, Todd, Pollara, Justin, Santra, Sampa, Vandergrift, Nathan, Pittala, Srivamshi, Bailey-Kellogg, Chris, Shen, Xiaoying, Parks, Robert, Goodman, Derrick, Eaton, Amanda, Balachandran, Harikrishnan, Mach, Linh V., Saunders, Kevin O., Weiner, Joshua A., Scearce, Richard, Sutherland, Laura L., Phogat, Sanjay, Tartaglia, Jim, Reed, Steven G., Hu, Shiu-Lok, Theis, James F., Pinter, Abraham, Montefiori, David C., Kepler, Thomas B., Peachman, Kristina K., Rao, Mangala, Michael, Nelson L., Suscovich, Todd J., Alter, Galit, Ackerman, Margaret E., Moody, M. Anthony, Liao, Hua-Xin, Tomaras, Georgia, Ferrari, Guido, Korber, Bette T., and Haynes, Barton F.

Published
2017
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15. Validation of SARS-CoV-2 pooled testing for surveillance using the Panther Fusion® system: Impact of pool size, automation, and assay chemistry.

Author

Park, Rudolph, Chandrasekaran, Prabha, Hernandez, Heather, Lakhal-Naouar, Ines, Peachman, Kristina K., Hack, Holly R., Coleman, Dante, Ouellette, Jason, Darden, Janice M., M'hamdi, Oussama, Sugiharto, Victor A., Chen, Hua-Wei, Schilling, Megan A., Simons, Mark P., Collins, Natalie D., Johnson, Yuliya S., Jagodzinski, Linda L., and Peel, Sheila A.

Subjects
AUTOMATION, DIAGNOSTIC specimens, OCHRATOXINS, TURNAROUND time, NUCLEIC acids, SARS-CoV-2, DETECTION limit
Abstract

Combining diagnostic specimens into pools has been considered as a strategy to augment throughput, decrease turnaround time, and leverage resources. This study utilized a multi-parametric approach to assess optimum pool size, impact of automation, and effect of nucleic acid amplification chemistries on the detection of SARS-CoV-2 RNA in pooled samples for surveillance testing on the Hologic Panther Fusion® System. Dorfman pooled testing was conducted with previously tested SARS-CoV-2 nasopharyngeal samples using Hologic's Aptima® and Panther Fusion® SARS-CoV-2 Emergency Use Authorization assays. A manual workflow was used to generate pool sizes of 5:1 (five samples: one positive, four negative) and 10:1. An automated workflow was used to generate pool sizes of 3:1, 4:1, 5:1, 8:1 and 10:1. The impact of pool size, pooling method, and assay chemistry on sensitivity, specificity, and lower limit of detection (LLOD) was evaluated. Both the Hologic Aptima® and Panther Fusion® SARS-CoV-2 assays demonstrated >85% positive percent agreement between neat testing and pool sizes ≤5:1, satisfying FDA recommendation. Discordant results between neat and pooled testing were more frequent for positive samples with CT>35. Fusion® CT (cycle threshold) values for pooled samples increased as expected for pool sizes of 5:1 (CT increase of 1.92–2.41) and 10:1 (CT increase of 3.03–3.29). The Fusion® assay demonstrated lower LLOD than the Aptima® assay for pooled testing (956 vs 1503 cp/mL, pool size of 5:1). Lowering the cut-off threshold of the Aptima® assay from 560 kRLU (manufacturer's setting) to 350 kRLU improved the assay sensitivity to that of the Fusion® assay for pooled testing. Both Hologic's SARS-CoV-2 assays met the FDA recommended guidelines for percent positive agreement (>85%) for pool sizes ≤5:1. Automated pooling increased test throughput and enabled automated sample tracking while requiring less labor. The Fusion® SARS-CoV-2 assay, which demonstrated a lower LLOD, may be more appropriate for surveillance testing. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

Author

King, Hannah A. D., primary, Gordon Joyce, M., additional, Naouar, Ines Elakhal, additional, Ahmed, Aslaa, additional, Cincotta, Camila Macedo, additional, Subra, Caroline, additional, Peachman, Kristina K., additional, Hack, Holly H., additional, Chen, Rita E., additional, Thomas, Paul V., additional, Chen, Wei-Hung, additional, Sankhala, Rajeshwer S., additional, Hajduczki, Agnes, additional, Martinez, Elizabeth J., additional, Peterson, Caroline E., additional, Chang, William C., additional, Choe, Misook, additional, Smith, Clayton, additional, Headley, Jarrett A., additional, Elyard, Hanne A., additional, Cook, Anthony, additional, Anderson, Alexander, additional, Wuertz, Kathryn McGuckin, additional, Dong, Ming, additional, Swafford, Isabella, additional, Case, James B., additional, Currier, Jeffrey R., additional, Lal, Kerri G., additional, Amare, Mihret F., additional, Dussupt, Vincent, additional, Molnar, Sebastian, additional, Daye, Sharon P., additional, Zeng, Xiankun, additional, Barkei, Erica K., additional, Alfson, Kendra, additional, Staples, Hilary M., additional, Carrion, Ricardo, additional, Krebs, Shelly J., additional, Paquin-Proulx, Dominic, additional, Karasavvas, Nicos, additional, Polonis, Victoria R., additional, Jagodzinski, Linda L., additional, Vasan, Sandhya, additional, Scott, Paul T., additional, Huang, Yaoxing, additional, Nair, Manoj S., additional, Ho, David D., additional, de Val, Natalia, additional, Diamond, Michael S., additional, Lewis, Mark G., additional, Rao, Mangala, additional, Matyas, Gary R., additional, Gromowski, Gregory D., additional, Peel, Sheila A., additional, Michael, Nelson L., additional, Modjarrad, Kayvon, additional, and Bolton, Diane L., additional

Published
2021
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17. Efficacy of a Broadly Neutralizing SARS-CoV-2 Ferritin Nanoparticle Vaccine in Nonhuman Primates

Author

Joyce, Michael G., primary, King, Hannah A. D., additional, Naouar, Ines Elakhal, additional, Ahmed, Aslaa, additional, Peachman, Kristina K., additional, Cincotta, Camila Macedo, additional, Subra, Caroline, additional, Chen, Rita E., additional, Thomas, Paul V., additional, Chen, Wei-Hung, additional, Sankhala, Rajeshwer S., additional, Hajduczki, Agnes, additional, Martinez, Elizabeth J., additional, Peterson, Caroline E., additional, Chang, William C., additional, Choe, Misook, additional, Smith, Clayton, additional, Lee, Parker J., additional, Headley, Jarrett A., additional, Taddese, Mekdi G., additional, Elyard, Hanne A., additional, Cook, Anthony, additional, Anderson, Alexander, additional, McGuckin-Wuertz, Kathryn, additional, Dong, Ming, additional, Swafford, Isabella, additional, Case, James B., additional, Currier, Jeffrey R., additional, Lal, Kerri G., additional, O’Connell, Robert J., additional, Molnar, Sebastian, additional, Nair, Manoj S., additional, Dussupt, Vincent, additional, Daye, Sharon P., additional, Zeng, Xiankun, additional, Barkei, Erica K., additional, Staples, Hilary M., additional, Alfson, Kendra, additional, Carrion, Ricardo, additional, Krebs, Shelly J., additional, Paquin-Proulx, Dominic, additional, Karasavva, Nicos, additional, Polonis, Victoria R., additional, Jagodzinski, Linda L., additional, Amare, Mihret F., additional, Vasan, Sandhya, additional, Scott, Paul T., additional, Huang, Yaoxing, additional, Ho, David D., additional, de Val, Natalia, additional, Diamond, Michael S., additional, Lewis, Mark G., additional, Rao, Mangala, additional, Matyas, Gary R., additional, Gromowski, Gregory D., additional, Peel, Sheila A., additional, Michael, Nelson L., additional, Bolton, Diane L., additional, and Modjarrad, Kayvon, additional

Published
2021
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19. Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

Author

Liao, Hua-Xin, Bonsignori, Mattia, Alam, Munir S., McLellan, Jason S., Tomaras, Georgia D., Moody, Anthony M., Kozink, Daniel M., Hwang, Kwan-Ki, Chen, Xi, Tsao, Chun-Yen, Liu, Pinghuang, Lu, Xiaozhi, Parks, Robert J., Montefiori, David C., Ferrari, Guido, Pollara, Justin, Rao, Mangala, Peachman, Kristina K., Santra, Sampa, Letvin, Norman L., Karasavvas, Nicos, Yang, Zhi-Yong, Dai, Kaifan, Pancera, Marie, Gorman, Jason, Wiehe, Kevin, Nicely, Nathan I., Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Tartaglia, James, Sinangil, Faruk, Kim, Jerome H., Michael, Nelson L., Kepler, Thomas B., Kwong, Peter D., Mascola, John R., Nabel, Gary J., Pinter, Abraham, Zolla-Pazner, Susan, and Haynes, Barton F.

Published
2013
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25. Modulation of Antibody Responses to the V1V2 and V3 Regions of HIV-1 Envelope by Immune Complex Vaccines

Author

Hioe, Catarina E., primary, Kumar, Rajnish, additional, Upadhyay, Chitra, additional, Jan, Muzafar, additional, Fox, Alisa, additional, Itri, Vincenza, additional, Peachman, Kristina K., additional, Rao, Mangala, additional, Liu, Lily, additional, Lo, Nathan C., additional, Tuen, Michael, additional, Jiang, Xunqing, additional, Kong, Xiang-Peng, additional, and Zolla-Pazner, Susan, additional

Published
2018
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28. Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Author

Kijak, Gustavo H., primary, Sanders-Buell, Eric, additional, Chenine, Agnes-Laurence, additional, Eller, Michael A., additional, Goonetilleke, Nilu, additional, Thomas, Rasmi, additional, Leviyang, Sivan, additional, Harbolick, Elizabeth A., additional, Bose, Meera, additional, Pham, Phuc, additional, Oropeza, Celina, additional, Poltavee, Kultida, additional, O’Sullivan, Anne Marie, additional, Billings, Erik, additional, Merbah, Melanie, additional, Costanzo, Margaret C., additional, Warren, Joanna A., additional, Slike, Bonnie, additional, Li, Hui, additional, Peachman, Kristina K., additional, Fischer, Will, additional, Gao, Feng, additional, Cicala, Claudia, additional, Arthos, James, additional, Eller, Leigh A., additional, O’Connell, Robert J., additional, Sinei, Samuel, additional, Maganga, Lucas, additional, Kibuuka, Hannah, additional, Nitayaphan, Sorachai, additional, Rao, Mangala, additional, Marovich, Mary A., additional, Krebs, Shelly J., additional, Rolland, Morgane, additional, Korber, Bette T., additional, Shaw, George M., additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, and Kim, Jerome H., additional

Published
2017
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30. Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin

Author

Chand, Subhash, primary, Messina, Emily L., additional, AlSalmi, Wadad, additional, Ananthaswamy, Neeti, additional, Gao, Guofen, additional, Uritskiy, Gherman, additional, Padilla-Sanchez, Victor, additional, Mahalingam, Marthandan, additional, Peachman, Kristina K., additional, Robb, Merlin L., additional, Rao, Mangala, additional, and Rao, Venigalla B., additional

Published
2017
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31. Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Author

Kijak, Gustavo H., primary, Sanders-Buell, Eric, additional, Chenine, Agnes-Laurence, additional, Eller, Michael A., additional, Goonetilleke, Nilu, additional, Thomas, Rasmi, additional, Leviyang, Sivan, additional, Harbolick, Elizabeth A., additional, Bose, Meera, additional, Pham, Phuc, additional, Oropeza, Celina, additional, Poltavee, Kultida, additional, O’Sullivan, Anne Marie, additional, Billings, Erik, additional, Merbah, Melanie, additional, Costanzo, Margaret C., additional, Warren, Joanna A., additional, Slike, Bonnie, additional, Li, Hui, additional, Peachman, Kristina K., additional, Fischer, Will, additional, Gao, Feng, additional, Cicala, Claudia, additional, Arthos, James, additional, Eller, Leigh A., additional, O’Connell, Robert J., additional, Sinei, Samuel, additional, Maganga, Lucas, additional, Kibuuka, Hannah, additional, Nitayaphan, Sorachai, additional, Rao, Mangala, additional, Marovich, Mary A., additional, Krebs, Shelly J., additional, Rolland, Morgane, additional, Korber, Bette T., additional, Shaw, George M., additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, and Kim, Jerome H., additional

Published
2017
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32. Development of a combination heroin-HIV vaccine

Author

Matyas, Gary R., primary, Torres, Oscar, additional, Jalah, Rashmi, additional, Antoline, Joshua, additional, Peachman, Kristina K., additional, Rao, Mangala, additional, Jacobson, Arthur, additional, Alving, Carl, additional, and Rice, Kenner, additional

Published
2017
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33. Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte–derived macrophages: the importance of HIV-1 envelope V1V2 region

Author

Jobe, Ousman, primary, Trinh, Hung V, additional, Kim, Jiae, additional, Alsalmi, Wadad, additional, Tovanabutra, Sodsai, additional, Ehrenberg, Philip K, additional, Peachman, Kristina K, additional, Gao, Guofen, additional, Thomas, Rasmi, additional, Kim, Jerome H, additional, Michael, Nelson L, additional, Alving, Carl R, additional, Rao, Venigalla B, additional, and Rao, Mangala, additional

Published
2015
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34. Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor

Author

Peachman, Kristina K., primary, Karasavvas, Nicos, additional, Chenine, Agnes-Laurence, additional, McLinden, Robert, additional, Rerks-Ngarm, Supachai, additional, Jaranit, Kaewkungwal, additional, Nitayaphan, Sorachai, additional, Pitisuttithum, Punnee, additional, Tovanabutra, Sodsai, additional, Zolla-Pazner, Susan, additional, Michael, Nelson L., additional, Kim, Jerome H., additional, Alving, Carl R., additional, and Rao, Mangala, additional

Published
2015
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