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1. Computer-aided diagnosis for the resect-and-discard strategy for colorectal polyps: a systematic review and meta-analysis

Author

Carrara, Silvia, Fugazza, Alessandro, Capogreco, Antonio, Massimi, Davide, Djinbachian, Roupen, Takishima, Kazumi, Mochizuki, Kenichi, Miyata, Yuki, Mochida, Kentaro, Akimoto, Yoshika, Kuroki, Takanori, Morita, Yuriko, Shiina, Osamu, Kato, Shun, Barua, Ishita, Holme, Øyvind, Wieszczy, Paulina, Løberg, Magnus, Kalager, Mette, Gulati, Shraddha, Williams, Sophie, Hayee, Bu, Patel, Mehul, Gunasingam, Nishmi, Kent, Alexandra, Emmanuel, Andrew, Haji, Amyn, Itoh, Hayato, Mori, Kensaku, Nemoto, Tetsuo, Munck, Carl, Aksel Nilsen, Jens, Astrup Hvattum, Stine, Oskar Frigstad, Svein, Tandberg, Petter, Lanza, Davide, Bonanno, Giacomo, Hassan, Cesare, Rizkala, Tommy, Mori, Yuichi, Spadaccini, Marco, Misawa, Masashi, Antonelli, Giulio, Rondonotti, Emanuele, Dekker, Evelien, Houwen, Britt B S L, Pech, Oliver, Baumer, Sebastian, Li, James Weiquan, von Renteln, Daniel, Haumesser, Claire, Maselli, Roberta, Facciorusso, Antonio, Correale, Loredana, Menini, Maddalena, Schilirò, Alessandro, Khalaf, Kareem, Patel, Harsh, Radadiya, Dhruvil K, Bhandari, Pradeep, Kudo, Shin-ei, Sultan, Shahnaz, Vandvik, Per Olav, Sharma, Prateek, Rex, Douglas K, Foroutan, Farid, and Repici, Alessandro

Published
2024
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2. Computer-aided diagnosis improves characterization of Barrett’s neoplasia by general endoscopists (with video)

Author

Alkhalaf, Alaa, Herrero, Lorenza Alvarez, Baldaque-Silva, Francisco, Barret, Maximilien, Bergman, Jacques J., Beyna, Torsten, Bisschops, Raf, Boers, Tim G., Curvers, Wouter, Deprez, Pierre H., Duits, Lucas C., Elbe, Peter, Esteban, Jose Miguel, Falk, Gary W., Fockens, Kiki N., Ginsberg, Gregory G., de Groof, Albert J., Haidry, Rehan, Houben, Martin H., Infantolino, Anthony, Iyer, Prasad G., Jong, Martijn, Jonge, Pieter-Jan de, Jukema, Jelmer B., Koch, Arjun, Komanduri, Srinadh, Konda, Vani, Kusters, Koen C., Leclerq, Philippe, Leggett, Cadman L., Lightdale, Charles J., Mallant-Hent, Rosalie C., Villarejo, Guiomar Moral, Fernández-Sordo, Jacobo Ortiz, Pech, Oliver, Penman, Ian, Pouw, Roos E., van der Putten, Joost A., Ragunath, Krish, Scholten, Pieter, Seewald, Stefan, Sethi, Amritha, Smith, Michael S., van der Sommen, Fons, Trindade, Arvind, Wani, Sachin, Waxman, Irving, Westerhof, Jessie, Weusten, Bas L., de With, Peter H., Wolfsen, Herbert C., Kusters, Carolus H.J., Jong, Martijn R., Boers, Tim, Weusten, Bas L.A.M., Houben, Martin H.M.G., Nagengast, Wouter B., Mallant-Hent, Rosalie, Silva, Francisco Baldaque, Ortiz Fernández-Sordo, Jacobo, Moral Villarejo, Guiomar, Montazeri, Nahid S.M., der Sommen, Fons van, and de Groof, A. Jeroen

Published
2024
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3. Cold Versus Hot Snare Endoscopic Resection of Large Nonpedunculated Colorectal Polyps: Randomized Controlled German CHRONICLE Trial

Author

Steinbrück, Ingo, Ebigbo, Alanna, Kuellmer, Armin, Schmidt, Arthur, Kouladouros, Konstantinos, Brand, Markus, Koenen, Teresa, Rempel, Viktor, Wannhoff, Andreas, Faiss, Siegbert, Pech, Oliver, Möschler, Oliver, Dumoulin, Franz Ludwig, Kirstein, Martha M., von Hahn, Thomas, Allescher, Hans-Dieter, Gölder, Stefan K., Götz, Martin, Hollerbach, Stephan, Lewerenz, Björn, Meining, Alexander, Messmann, Helmut, Rösch, Thomas, and Allgaier, Hans-Peter

Published
2024
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4. The use of a real-time computer-aided detection system for visible lesions in the Barrett’s esophagus during live endoscopic procedures: a pilot study (with video)

Author

Alkhalaf, Alaa, Herrero, Lorenza Alvarez, Baldaque-Silva, Francisco, Barret, Maximilien, Bergman, Jacques J., Beyna, Torsten, Boers, Tim G., Elbe, Peter, Fockens, Kiki N., de Groof, Albert J., Houben, Martin H., Jong, Martijn, Jukema, Jelmer B., Kusters, Koen C., Mallant-Hent, Rosalie C., Villarejo, Guiomar Moral, Nagengast, Wouter, Fernández-Sordo, Jacobo Ortiz, Pech, Oliver, Pouw, Roos E., van der Putten, Joost A., Ragunath, Krish, Scholten, Pieter, Seewald, Stefan, der Sommen, Fons van, Westerhof, Jessie, Weusten, Bas L., de With, Peter H., Jong, Martijn R., Boers, Tim, Kusters, Carolus H.J., Duits, Lucas C., van der Sommen, Fons, and de Groof, A. Jeroen

Published
2024
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6. Accuracy of Computer-aided Diagnosis in Colonoscopy Varies According to Polyp Location: A Systematic Review and Meta-analysis

Author

Rizkala, Tommy, Hassan, Cesare, Mori, Yuichi, Spadaccini, Marco, Antonelli, Giulio, Dekker, Evelien, Houwen, Britt B.S.L., Pech, Oliver, Baumer, Sebastian, Rondonotti, Emanuele, Radaelli, Franco, Li, James Weiquan, von Renteln, Daniel, Misawa, Masashi, Facciorusso, Antonio, Maselli, Roberta, Carrara, Silvia, Fugazza, Alessandro, Capogreco, Antonio, Khalaf, Kareem, Patel, Harsh, Sharma, Prateek, Rex, Douglas, and Repici, Alessandro

Published
2024
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9. S2k guideline Gastroesophageal reflux disease and eosinophilic esophagitis of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS).

Author

MadischAhmed120000-0002-7904-7893KoopHerbert3MiehlkeStephan45LeersJessica67LorenzPia8JansenPetra Lynen8PechOliver9SchillingDieter10LabenzJoachim11, Madisch, Ahmed, Koop, Herbert, Miehlke, Stephan, Leers, Jessica, Lorenz, Pia, Jansen, Petra Lynen, Pech, Oliver, Schilling, Dieter, Labenz, Joachim, AllescherHans-DieterBläkerHendrikCacaKarelFrielingThomasGranderathFrank A.HörningAndréHosieStuartLangerRupertMessmannHelmutMöllerGudrunPehlChristianSchlagChristophSchmidt-ChoudhuryAnjonavon ArnimUlrikeWenzlTobias, Allescher, Hans-Dieter, Bläker, Hendrik, Caca, Karel, Frieling, Thomas, Granderath, Frank A., Hörning, André, Hosie, Stuart, Langer, Rupert, and Messmann, Helmut

Published
2024
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10. Cold versus Hot Snare Endoscopic Resection of Large Non-Pedunculated Colorectal Polyps (Randomized-controlled German CHRONICLE-trial)

Author

Steinbrück, Ingo, primary, Ebigbo, Alanna, additional, Kuellmer, Armin, additional, Schmidt, Arthur, additional, Kouladouros, Konstantinos, additional, Brand, Markus, additional, Koenen, Teresa, additional, Rempel, Viktor, additional, Wannhoff, Andreas, additional, Faiss, Siegbert, additional, Pech, Oliver, additional, Möschler, Oliver, additional, Dumoulin, Franz Ludwig, additional, Kirstein, Martha M., additional, von Hahn, Thomas, additional, Allescher, Hans-Dieter, additional, Gölder, Stefan, additional, Götz, Martin, additional, Hollerbach, Stephan, additional, Lewerenz, Björn, additional, Meining, Alexander, additional, Messmann, Helmut, additional, Rösch, Thomas, additional, and Allgaier, Hans-Peter, additional

Published
2024
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11. COMPUTER-AIDED DIAGNOSIS IMPROVES CHARACTERIZATION OF BARRETT’S NEOPLASIA BY GENERAL ENDOSCOPISTS

Author

Jukema, Jelmer B., primary, Kusters, Carolus H.J., additional, Jong, Martijn R., additional, Fockens, Kiki N., additional, Boers, Tim, additional, van der Putten, Joost A., additional, Pouw, Roos E., additional, Duits, Lucas C., additional, Weusten, BasL.A.M., additional, Herrero, Lorenza. Alvarez, additional, Houben, Martin H.M.G., additional, Nagengast, Wouter B., additional, Westerhof, Jessie, additional, Alkhalaf, Alaa, additional, Mallant-Hent, Rosalie, additional, Scholten, Pieter, additional, Ragunath, Krish, additional, Seewald, Stefan, additional, Elbe, Peter, additional, Silva, Francisco Baldaque, additional, Barret, Maximilien, additional, Fernández-Sordo, Jacobo Ortiz, additional, Villarejo, Guiomar Moral, additional, Pech, Oliver, additional, Beyna, Torsten, additional, Montazeri, Nahid S.M., additional, van der Sommen, Fons, additional, de With, Peter H., additional, de Groof, A. Jeroen, additional, Bergman, Jacques J., additional, Herrero, Lorenza Alvarez, additional, Baldaque-Silva, Francisco, additional, Bisschops, Raf, additional, Boers, Tim G., additional, Curvers, Wouter, additional, Deprez, Pierre H., additional, Esteban, Jose Miguel, additional, Falk, Gary W., additional, Ginsberg, Gregory G., additional, de Groof, Albert J., additional, Haidry, Rehan, additional, Houben, Martin H., additional, Infantolino, Anthony, additional, Iyer, Prasad G., additional, Jong, Martijn, additional, Jonge, Pieter-Jan de, additional, Jukema, Jelmer B., additional, Koch, Arjun, additional, Komanduri, Srinadh, additional, Konda, Vani, additional, Kusters, Koen C., additional, Leclerq, Philippe, additional, Leggett, Cadman L., additional, Lightdale, Charles J., additional, Mallant-Hent, Rosalie C., additional, Muthusamy, V Raman, additional, Penman, Ian, additional, Sethi, Amritha, additional, Smith, Michael S., additional, Trindade, Arvind, additional, Wani, Sachin, additional, Waxman, Irving, additional, Weusten, Bas L., additional, and Wolfsen, Herbert C., additional

Published
2024
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12. Computer-aided diagnosis for the resect-and-discard strategy for colorectal polyps: a systematic review and meta-analysis

Author

Hassan, Cesare, Rizkala, Tommy, Mori, Yuichi, Spadaccini, Marco, Misawa, Masashi, Antonelli, Giulio, Rondonotti, Emanuele, Dekker, Evelien, Houwen, Britt B S L, Pech, Oliver, Baumer, Sebastian, Li, James Weiquan, von Renteln, Daniel, Haumesser, Claire, Maselli, Roberta, Facciorusso, Antonio, Correale, Loredana, Menini, Maddalena, Schilirò, Alessandro, Khalaf, Kareem, Patel, Harsh, Radadiya, Dhruvil K, Bhandari, Pradeep, Kudo, Shin-ei, Sultan, Shahnaz, Vandvik, Per Olav, Sharma, Prateek, Rex, Douglas K, Foroutan, Farid, Repici, Alessandro, Carrara, Silvia, Fugazza, Alessandro, Capogreco, Antonio, Massimi, Davide, Djinbachian, Roupen, Takishima, Kazumi, Mochizuki, Kenichi, Miyata, Yuki, Mochida, Kentaro, Akimoto, Yoshika, Kuroki, Takanori, Morita, Yuriko, Shiina, Osamu, Kato, Shun, Barua, Ishita, Holme, Øyvind, Wieszczy, Paulina, Løberg, Magnus, Kalager, Mette, Gulati, Shraddha, Williams, Sophie, Hayee, Bu, Patel, Mehul, Gunasingam, Nishmi, Kent, Alexandra, Emmanuel, Andrew, Haji, Amyn, Itoh, Hayato, Mori, Kensaku, Nemoto, Tetsuo, Munck, Carl, Aksel Nilsen, Jens, Astrup Hvattum, Stine, Oskar Frigstad, Svein, Tandberg, Petter, Lanza, Davide, and Bonanno, Giacomo

Abstract

The resect-and-discard strategy allows endoscopists to replace post-polypectomy pathology with real-time prediction of polyp histology during colonoscopy (optical diagnosis). We aimed to investigate the benefits and harms of implementing computer-aided diagnosis (CADx) for polyp pathology into the resect-and-discard strategy.

Published
2024
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13. Expert assessment of infiltration depth and recommendation of endoscopic resection technique in early Barrett cancer

Author

Younis, Fadi, Rösch, Thomas, Beyna, Torsten, Ebigbo, Alanna, Faiss, Siegbert, May, Andrea, Pech, Oliver, Dautel, Philip, Anders, Mario, Clauditz, Till, Zimmermann‐Fraedrich, Katharina, Sehner, Susanne, and Schachschal, Guido

Abstract

Early Barrett cancer can be curatively treated by endoscopic resection. The choice of the resection technique, however—endoscopic mucosal resection (EMR) or submucosal dissection (ESD)—largely depends on the assumed infiltration depth as judged by the endoscopist. However, the accuracy of endoscopic diagnosis of the degree of cancer infiltration is not known. Three to four high‐quality images (both in overview and close‐up) from 202 of early Barrett esophagus cancer cases (82% men, mean age 66.9 years) were selected from our endoscopy database (73.3% stage T1a and 26.7% in stage T1b). Images were shown to 9 Barrett esophagus experts, with patients' clinical data (age, sex, Barrett esophagus length) and biopsy results. The experts were asked to predict infiltration depth (T1b vs. T1a), and to suggest the appropriate endoscopic resection technique (EMR or ESD, or surgery). Interobserver variability (kappa values) was also determined for these parameters. Overall positive (PPV) and negative predictive values (NPV) to diagnose T1b versus T1a infiltration were 40.7% (95% CI: 36.7, 44.8) and 79.8% (95% CI: 77.5, 81.9), respectively; kappa value was 0.41. Paris classification (kappa 0.51) and suggested treatment also varied between experts. In a post hoc analysis, only the correlation between lesions classified as invisible or flat according to the Paris classification (IIB; 25% of all cases) and the suggested resection technique was better: In this subgroup, EMR was recommended in >80% of cases, with a high complete (basal R0) resection rate (mean of 88.1%). Precise endoscopic distinction between mucosal and submucosal involvement of Barrett esophagus cancer by experts as a basis for choosing the resection technique has limited predictive values and high interobserver variability. It seems that mainly invisible/flat lesions may result in good resection outcomes when treated by EMR, but this stratification strategy has to be assessed in further studies.

Published
2024
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16. A deep learning system for detection of early Barrett's neoplasia: a model development and validation study

Author

Fockens, K N, primary, Jong, M R, additional, Jukema, J B, additional, Boers, T G W, additional, Kusters, C H J, additional, van der Putten, J A, additional, Pouw, R E, additional, Duits, L C, additional, Montazeri, N S M, additional, van Munster, S N, additional, Weusten, B L A M, additional, Alvarez Herrero, L, additional, Houben, M H M G, additional, Nagengast, W B, additional, Westerhof, J, additional, Alkhalaf, A, additional, Mallant-Hent, R C, additional, Scholten, P, additional, Ragunath, K, additional, Seewald, S, additional, Elbe, P, additional, Baldaque-Silva, F, additional, Barret, M, additional, Ortiz Fernández-Sordo, J, additional, Villarejo, G Moral, additional, Pech, O, additional, Beyna, T, additional, van der Sommen, F, additional, de With, P H, additional, de Groof, A J, additional, Bergman, J J, additional, Alkhalaf, Alaa, additional, Alvarez Herrero, Lorenza, additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Bergman, Jacques J, additional, Beyna, Torsten, additional, Bisschops, Raf, additional, Boers, Tim G, additional, Curvers, Wouter, additional, Deprez, Pierre H, additional, Duits, Lucas C, additional, Elbe, Peter, additional, Esteban, Jose M, additional, Falk, Gary W, additional, Fockens, Kiki N, additional, Ganguly, Eric, additional, Ginsberg, Gregory G, additional, de Groof, Albert J, additional, Haidry, Rehan, additional, Houben, Martin H, additional, Infantolino, Anthony, additional, Iyer, Prasad G, additional, Jong, Martijn R, additional, De Jonge, Pieter-Jan, additional, Jukema, Jelmer B, additional, Koch, Arjun K, additional, Komanduri, Srinadh, additional, Konda, Vani, additional, Kusters, Carolus H J, additional, Leclercq, Philippe, additional, Leggett, Cadman L, additional, Lemmers, Arnaud, additional, Lightdale, Charles J, additional, Mallant-Hent, Rosalie C, additional, Moral Villarejo, Guiomar, additional, Muthusamy, V Raman, additional, Nagengast, Wouter, additional, Ortiz Fernández-Sordo, Jacobo, additional, Pech, Oliver, additional, Penman, Ian, additional, Pleskow, Douglas K, additional, Pouw, Roos E, additional, van der Putten, Joost A, additional, Ragunath, Krish, additional, Scholten, Pieter, additional, Seewald, Stefan, additional, Sethi, Amritha, additional, Smith, Michael S, additional, Van der Sommen, Fons, additional, Trindade, Arvind, additional, Wani, Sachin, additional, Waxman, Irving, additional, Westerhof, Jessie, additional, Weusten, Bas L, additional, de With, Peter H N, additional, and Wolfsen, Herbert C, additional

Published
2023
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19. S3-Leitlinie Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus.

Author

Ebert, Matthias P., Fischbach, Wolfgang, Hollerbach, Stephan, Höppner, Jens, Lorenz, Dietmar, Stahl, Michael, Stuschke, Martin, Pech, Oliver, Vanhoefer, Udo, Porschen, Rainer, Baretton, Gustavo, Bostel, Tilmann, Bruns, Christiane, Ell, Christian, Follmann, Markus, Goerling, Ute, Grenacher, Lars, Haardt, Julia, Hölscher, Arnulf H., and Hummel, Richard

Published
2024
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21. Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Author

Weusten, Bas L. A. M., additional, Bisschops, Raf, additional, Dinis-Ribeiro, Mario, additional, di Pietro, Massimiliano, additional, Pech, Oliver, additional, Spaander, Manon C. W., additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Coron, Emmanuel, additional, Fernández-Esparrach, Glòria, additional, Fitzgerald, Rebecca C., additional, Jansen, Marnix, additional, Jovani, Manol, additional, Marques-de-Sa, Ines, additional, Rattan, Arti, additional, Tan, W. Keith, additional, Verheij, Eva P. D., additional, Zellenrath, Pauline A., additional, Triantafyllou, Konstantinos, additional, and Pouw, Roos E., additional

Published
2023
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22. Accuracy of polyp characterization by artificial intelligence and endoscopists: a prospective, non-randomized study in a tertiary endoscopy center

Author

Baumer, Sebastian, primary, Streicher, Kilian, primary, Alqahtani, Saleh A., additional, Brookman-Amissah, Dominic, additional, Brunner, Monika, additional, Federle, Christoph, additional, Muehlenberg, Klaus, additional, Pfeifer, Lukas, additional, Salzberger, Andrea, additional, Schorr, Wolfgang, additional, Zustin, Jozef, additional, and Pech, Oliver, additional

Published
2023
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24. A prospective multicenter study using a new multiband mucosectomy device for endoscopic resection of early neoplasia in Barrett’s esophagus

Author

Pouw, Roos E., Beyna, Torsten, Belghazi, Kamar, Koch, Arjun D., Schoon, Erik J., Haidry, Rehan, Weusten, Bas L., Bisschops, Raf, Shaheen, Nicholas J., Wallace, Michael B., Marcon, Norman, Heise-Ginsburg, Rachel, Gotink, Anniek W., Wang, Kenneth K., Leggett, Cadman L., Ortiz-Fernández-Sordo, Jacobo, Ragunath, Krish, DiPietro, Massimiliano, Pech, Oliver, Neuhaus, Horst, and Bergman, Jacques J.

Published
2018
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25. 300. ENDOSCOPIC FOLLOW-UP OF RADICALLY RESECTED SUBMUCOSAL ESOPHAGEAL ADENOCARCINOMA: PRELIMINARY RESULTS OF AN ONGOING PROSPECTIVE, INTERNATIONAL, MULTICENTER COHORT REGISTRY (PREFER TRIAL)

Author

Pouw, Roos, primary, Nieuwenhuis, Esther, additional, Jansen, Marnix, additional, Koch, Arjun, additional, Spaander, Manon, additional, Nagengast, Wouter, additional, Westerhof, Jessie, additional, Bisschops, Raf, additional, De Hertogh, Gert, additional, Neuhaus, Horst, additional, Beyna, Torsten, additional, Bourke, Michael, additional, Weusten, Bas, additional, Alkhalaf, Alaa, additional, Pech, Oliver, additional, Seewald, Stefan, additional, Haidry, Rehan, additional, Schoon, Erik, additional, Schlag, Christoph, additional, De Wulf, Dominiek, additional, Houben, Martin, additional, Messman, Helmut, additional, Dewint, Pieter, additional, Ortiz, Jacobo, additional, Meijer, Sybren, additional, Bergman, Jacques, additional, and Pouw, Roos, additional

Published
2023
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26. CLINICAL VALIDATION OF A COMPUTER-AIDED DETECTION MODEL FOR COLORECTAL POLYP DETECTION (CAD-ARTIPOD) TRIAL USING A SECOND OBSERVER AND REAL-TIME UNBLINDING

Author

Sinonquel, Pieter, primary, Eelbode, Tom, additional, Pech, Oliver, additional, De Wulf, Dominiek, additional, Dewint, Pieter, additional, Neumann, Helmut, additional, Antonelli, Giulio, additional, Tate, David, additional, Lemmers, Arnaud, additional, Pilonis, Nastazja, additional, Kaminski, Michal, additional, Demedts, Ingrid, additional, Hassan, Cesare, additional, Roelandt, Philip, additional, Maes, Frederik, additional, and Bisschops, Raf, additional

Published
2023
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27. COMPUTER-AIDED DIAGNOSIS (CADX) IMPROVES CHARACTERIZATION OF BARRETT’S NEOPLASIA BY ENDOSCOPISTS

Author

Jukema, Jelmer, primary, Kusters, Koen, additional, Jong, Martijn, additional, Fockens, Kiki, additional, Boers, Tim, additional, Van Der Putten, Joost, additional, Pouw, Roos, additional, Duits, Lucas, additional, Weusten, Bas, additional, Herrero, L. Alvarez, additional, Houben, Martin, additional, Nagengast, Wouter, additional, Westerhof, Jessie, additional, Alkhalaf, A., additional, Mallant-Hent, Rosalie, additional, Scholten, Pieter, additional, Ragunath, Krish, additional, Seewald, Stefan, additional, Elbe, Peter, additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Fernández-Sordo, Jacobo Ortiz, additional, Villarejo, Guiomar Moral, additional, Pech, Oliver, additional, Beyna, Torsten, additional, Van Der Sommen, Fons, additional, De With, P.H.N., additional, De Groof, Jeroen, additional, and Bergman, Jacques, additional

Published
2023
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28. VIDEO-BASED COMPUTER AIDED DETECTION SYSTEM IMPROVES BARRETT’S NEOPLASIA DETECTION OF GENERAL ENDOSCOPISTS IN A MULTI-STEP BENCHMARKING STUDY

Author

Jong, Martijn, primary, Fockens, Kiki, additional, Jukema, Jelmer, additional, Boers, Tim, additional, Kusters, Koen, additional, Van Der Putten, Joost, additional, Pouw, Roos, additional, Duits, Lucas, additional, Weusten, Bas, additional, Herrero, L. Alvarez, additional, Houben, Martin, additional, Nagengast, Wouter, additional, Westerhof, Jessie, additional, Alkhalaf, A., additional, Mallant-Hent, Rosalie, additional, Scholten, Pieter, additional, Ragunath, Krish, additional, Seewald, Stefan, additional, Elbe, Peter, additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Fernández-Sordo, Jacobo Ortiz, additional, Villarejo, Guiomar Moral, additional, Pech, Oliver, additional, Beyna, Torsten, additional, Van Der Sommen, Fons, additional, De With, P.H.N., additional, De Groof, Jeroen, additional, and Bergman, Jacques, additional

Published
2023
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30. Updated German guideline on diagnosis and treatment of squamous cell carcinoma and adenocarcinoma of the esophagus

Author

Porschen, Rainer, Fischbach, Wolfgang, Gockel, Ines, Hollerbach, Stephan, Hölscher, Arnulf, Jansen, Petra Lynen, Miehlke, Stephan, Pech, Oliver, Stahl, Michael, Vanhoefer, Udo, and Ebert, Matthias P. A.

Abstract

Diagnosis and therapy of esophageal carcinoma is challenging and requires a multidisciplinary approach. The purpose of the updated German guideline “Diagnosis and Treatment of Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus—version 3.1” is to provide practical and evidence‐based advice for the management of patients with esophageal cancer. Recommendations were developed by a multidisciplinary expert panel based on an extensive and systematic evaluation of the published medical literature and the application of well‐established methodologies (e.g. Oxford evidence grading scheme, grading of recommendations). Accurate diagnostic evaluation of the primary tumor as well as lymph node and distant metastases is required in order to guide patients to a stage‐appropriate therapy after the initial diagnosis of esophageal cancer. In high‐grade intraepithelial neoplasia or mucosal carcinoma endoscopic resection shall be performed. Whether endoscopic resection is the definitive therapeutic measure depends on the histopathological evaluation of the resection specimen. Esophagectomy should be performed minimally invasive or in combination with open procedures (hybrid technique). Because the prognosis in locally advanced esophageal carcinoma is poor with surgery alone, multimodality therapy is recommended. In locally advanced adenocarcinomas of the esophagus or esophagogastric junction, perioperative chemotherapy or preoperative radiochemotherapy should be administered. In locally advanced squamous cell carcinomas of the esophagus, preoperative radiochemotherapy followed by complete resection or definitive radiochemotherapy without surgery should be performed. In the case of residual tumor in the resection specimen after neoadjuvant radiochemotherapy and R0 resection of squamous cell carcinoma or adenocarcinoma, adjuvant immunotherapy with nivolumab should be given. Systemic palliative treatment options (chemotherapy, chemotherapy plus immunotherapy, immunotherapy alone) in unresectable or metastastic esophageal cancer depend on histology and are stratified according to PD‐L1 and/or Her2 expression.

Published
2024
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31. Development of quality indicators for endoscopic eradication therapies in Barrett’s esophagus: the TREAT-BE (Treatment with Resection and Endoscopic Ablation Techniques for Barrett’s Esophagus) Consortium

Author

Wani, Sachin, Muthusamy, V. Raman, Shaheen, Nicholas J., Yadlapati, Rena, Wilson, Robert, Abrams, Julian A., Bergman, Jacques, Chak, Amitabh, Chang, Kenneth, Das, Ananya, Dumot, John, Edmundowicz, Steven A., Eisen, Glenn, Falk, Gary W., Fennerty, M. Brian, Gerson, Lauren, Ginsberg, Gregory G., Grande, David, Hall, Matt, Harnke, Ben, Inadomi, John, Jankowski, Janusz, Lightdale, Charles J., Makker, Jitin, Odze, Robert D., Pech, Oliver, Sampliner, Richard E., Spechler, Stuart, Triadafilopoulos, George, Wallace, Michael B., Wang, Kenneth, Waxman, Irving, and Komanduri, Srinadh

Published
2017
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32. Towards a robust and compact deep learning system for primary detection of early Barrett’s neoplasia: Initial image‐based results of training on a multi‐center retrospectively collected data set

Author

Fockens, Kiki N., primary, Jukema, Jelmer B., additional, Boers, Tim, additional, Jong, Martijn R., additional, van der Putten, Joost A., additional, Pouw, Roos E., additional, Weusten, Bas L. A. M., additional, Alvarez Herrero, Lorenza, additional, Houben, Martin H. M. G., additional, Nagengast, Wouter B., additional, Westerhof, Jessie, additional, Alkhalaf, Alaa, additional, Mallant, Rosalie, additional, Ragunath, Krish, additional, Seewald, Stefan, additional, Elbe, Peter, additional, Barret, Maximilien, additional, Ortiz Fernández‐Sordo, Jacobo, additional, Pech, Oliver, additional, Beyna, Torsten, additional, van der Sommen, Fons, additional, de With, Peter H., additional, de Groof, A. Jeroen, additional, and Bergman, Jacques J., additional

Published
2023
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34. Endoscopic submucosal dissection techniques and technology: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review

Author

Libânio, Diogo, primary, Pimentel-Nunes, Pedro, primary, Bastiaansen, Barbara, additional, Bisschops, Raf, additional, Bourke, Michael J., additional, Deprez, Pierre H., additional, Esposito, Gianluca, additional, Lemmers, Arnaud, additional, Leclercq, Philippe, additional, Maselli, Roberta, additional, Messmann, Helmut, additional, Pech, Oliver, additional, Pioche, Mathieu, additional, Vieth, Michael, additional, Weusten, Bas L.A.M., additional, Fuccio, Lorenzo, additional, Bhandari, Pradeep, additional, and Dinis-Ribeiro, Mario, additional

Published
2023
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36. Wide-area transepithelial sampling with computer-assisted analysis to detect high grade dysplasia and cancer in Barrett's esophagus: a multicenter randomized study

Author

van Munster, Sanne N, Leclercq, Philippe, Haidry, Rehan, Messmann, Helmut, Probst, Andreas, Ragunath, Krish, Bhandari, Pradeep, Repici, Alessandro, Munoz-Navas, Miguel, Seewald, Stefan, Lemmers, Arnaud, Fernández-Esparrach, Glòria, Pech, Oliver, Schoon, Erik J, Kariv, Revital, Neuhaus, Horst, Weusten, Bas L A M, Siersema, Peter D, Correale, Loredana, Meijer, Sybren L, de Hertogh, Gert, Bergman, Jacques J G H M, Hassan, Cesare, Bisschops, Raf, van Munster, Sanne N, Leclercq, Philippe, Haidry, Rehan, Messmann, Helmut, Probst, Andreas, Ragunath, Krish, Bhandari, Pradeep, Repici, Alessandro, Munoz-Navas, Miguel, Seewald, Stefan, Lemmers, Arnaud, Fernández-Esparrach, Glòria, Pech, Oliver, Schoon, Erik J, Kariv, Revital, Neuhaus, Horst, Weusten, Bas L A M, Siersema, Peter D, Correale, Loredana, Meijer, Sybren L, de Hertogh, Gert, Bergman, Jacques J G H M, Hassan, Cesare, and Bisschops, Raf

Abstract

BACKGROUND: Current surveillance for Barrett's esophagus (BE), consisting of four-quadrant random forceps biopsies (FBs), has an inherent risk of sampling error. Wide-area transepithelial sampling (WATS) may increase detection of high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). In this multicenter randomized trial, we aimed to evaluate WATS as a substitute for FB.METHODS: Patients with known BE and a recent history of dysplasia, without visible lesions, at 17 hospitals were randomized to receive either WATS followed by FB or vice versa. All WATS samples were examined, with computer assistance, by at least two experienced pathologists at the CDx Diagnostics laboratory. Similarly, all FBs were examined by two expert pathologists. The primary end point was concordance/discordance for detection of HGD/EAC between the two techniques.RESULTS: 172 patients were included, of whom 21 had HGD/EAC detected by both modalities, 18 had HGD/EAC detected by WATS but missed by FB, and 12 were detected by FB but missed by WATS. The detection rate of HGD/EAC did not differ between WATS and FB (P = 0.36). Using WATS as an adjunct to FB significantly increased the detection of HGD/EAC vs. FB alone (absolute increase 10 % [95 %CI 6 % to 16 %]). Mean procedural times in minutes for FB alone, WATS alone, and the combination were 6.6 (95 %CI 5.9 to 7.1), 4.9 (95 %CI 4.1 to 5.4), and 11.2 (95 %CI 10.5 to 14.0), respectively.CONCLUSIONS: Although the combination of WATS and FB increases dysplasia detection in a population of BE patients enriched for dysplasia, we did not find a statistically significant difference between WATS and FB for the detection of HGD/EAC as single modality.

Published
2023

37. Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Author

MS MDL 1, Cancer, Weusten, Bas L.A.M., Bisschops, Raf, Dinis-Ribeiro, Mario, Di Pietro, Massimiliano, Pech, Oliver, Spaander, Manon C.W., Baldaque-Silva, Francisco, Barret, Maximilien, Coron, Emmanuel, Fernández-Esparrach, Glòria, Fitzgerald, Rebecca C., Jansen, Marnix, Jovani, Manol, Marques-De-Sa, Ines, Rattan, Arti, Tan, W. Keith, Verheij, Eva P.D., Zellenrath, Pauline A., Triantafyllou, Konstantinos, Pouw, Roos E., MS MDL 1, Cancer, Weusten, Bas L.A.M., Bisschops, Raf, Dinis-Ribeiro, Mario, Di Pietro, Massimiliano, Pech, Oliver, Spaander, Manon C.W., Baldaque-Silva, Francisco, Barret, Maximilien, Coron, Emmanuel, Fernández-Esparrach, Glòria, Fitzgerald, Rebecca C., Jansen, Marnix, Jovani, Manol, Marques-De-Sa, Ines, Rattan, Arti, Tan, W. Keith, Verheij, Eva P.D., Zellenrath, Pauline A., Triantafyllou, Konstantinos, and Pouw, Roos E.

Published
2023

38. Endoscopic submucosal dissection techniques and technology: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review

Author

MS MDL 1, Cancer, Libânio, Diogo, Pimentel-Nunes, Pedro, Bastiaansen, Barbara, Bisschops, Raf, Bourke, Michael J, Deprez, Pierre H, Esposito, Gianluca, Lemmers, Arnaud, Leclercq, Philippe, Maselli, Roberta, Messmann, Helmut, Pech, Oliver, Pioche, Mathieu, Vieth, Michael, Weusten, Bas L A M, Fuccio, Lorenzo, Bhandari, Pradeep, Dinis-Ribeiro, Mario, MS MDL 1, Cancer, Libânio, Diogo, Pimentel-Nunes, Pedro, Bastiaansen, Barbara, Bisschops, Raf, Bourke, Michael J, Deprez, Pierre H, Esposito, Gianluca, Lemmers, Arnaud, Leclercq, Philippe, Maselli, Roberta, Messmann, Helmut, Pech, Oliver, Pioche, Mathieu, Vieth, Michael, Weusten, Bas L A M, Fuccio, Lorenzo, Bhandari, Pradeep, and Dinis-Ribeiro, Mario

Published
2023

39. Towards a robust and compact deep learning system for primary detection of early Barrett’s neoplasia: Initial image-based results of training on a multi-center retrospectively collected data set

Author

MS MDL 1, Cancer, Fockens, Kiki N., Jukema, Jelmer B., Boers, Tim, Jong, Martijn R., van der Putten, Joost A., Pouw, Roos E., Weusten, Bas L.A.M., Alvarez Herrero, Lorenza, Houben, Martin H.M.G., Nagengast, Wouter B., Westerhof, Jessie, Alkhalaf, Alaa, Mallant, Rosalie, Ragunath, Krish, Seewald, Stefan, Elbe, Peter, Barret, Maximilien, Ortiz Fernández-Sordo, Jacobo, Pech, Oliver, Beyna, Torsten, van der Sommen, Fons, de With, Peter H., de Groof, A. Jeroen, Bergman, Jacques J., MS MDL 1, Cancer, Fockens, Kiki N., Jukema, Jelmer B., Boers, Tim, Jong, Martijn R., van der Putten, Joost A., Pouw, Roos E., Weusten, Bas L.A.M., Alvarez Herrero, Lorenza, Houben, Martin H.M.G., Nagengast, Wouter B., Westerhof, Jessie, Alkhalaf, Alaa, Mallant, Rosalie, Ragunath, Krish, Seewald, Stefan, Elbe, Peter, Barret, Maximilien, Ortiz Fernández-Sordo, Jacobo, Pech, Oliver, Beyna, Torsten, van der Sommen, Fons, de With, Peter H., de Groof, A. Jeroen, and Bergman, Jacques J.

Published
2023

40. Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis

Author

Gharahkhani, Puya, Fitzgerald, Rebecca C, Vaughan, Thomas L, Palles, Claire, Gockel, Ines, Tomlinson, Ian, Buas, Matthew F, May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Kreuser, Nicole, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Manner, Hendrik, Schmidt, Claudia, Hess, Timo, Böhmer, Anne C, Izbicki, Jakob R, Hölscher, Arnulf H, Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Hackelsberger, Andreas, Mayershofer, Rupert, Pech, Oliver, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismüller, Josef, Nöthen, Markus M, Attwood, Stephen, Barr, Hugh, Chegwidden, Laura, de Caestecker, John, Harrison, Rebecca, Love, Sharon B, MacDonald, David, Moayyedi, Paul, Prenen, Hans, Watson, R G Peter, Iyer, Prasad G, Anderson, Lesley A, Bernstein, Leslie, Chow, Wong-Ho, Hardie, Laura J, Lagergren, Jesper, Liu, Geoffrey, Risch, Harvey A, Wu, Anna H, Ye, Weimin, Bird, Nigel C, Shaheen, Nicholas J, Gammon, Marilie D, Corley, Douglas A, Caldas, Carlos, Moebus, Susanne, Knapp, Michael, Peters, Wilbert H M, Neuhaus, Horst, Rösch, Thomas, Ell, Christian, MacGregor, Stuart, Pharoah, Paul, Whiteman, David C, Jankowski, Janusz, and Schumacher, Johannes

Published
2016
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42. Clinical consequences of computer-aided colorectal polyp detection

Author

Sinonquel, Pieter, Eelbode, Tom, Pech, Oliver, De Wulf, Dominiek, Dewint, Pieter, Neumann, Helmut, Antonelli, Giulio, Iacopini, Federico, Tate, David, Lemmers, Arnaud, Pilonis, Nastazja Dagny, Kaminski, Michal Filip, Roelandt, Philip, Hassan, Cesare, Ingrid, Demedts, Maes, Frederik, and Bisschops, Raf

Abstract

Background and aimRandomised trials show improved polyp detection with computer-aided detection (CADe), mostly of small lesions. However, operator and selection bias may affect CADe’s true benefit. Clinical outcomes of increased detection have not yet been fully elucidated.MethodsIn this multicentre trial, CADe combining convolutional and recurrent neural networks was used for polyp detection. Blinded endoscopists were monitored in real time by a second observer with CADe access. CADe detections prompted reinspection. Adenoma detection rates (ADR) and polyp detection rates were measured prestudy and poststudy. Histological assessments were done by independent histopathologists. The primary outcome compared polyp detection between endoscopists and CADe.ResultsIn 946 patients (51.9% male, mean age 64), a total of 2141 polyps were identified, including 989 adenomas. CADe was not superior to human polyp detection (sensitivity 94.6% vs 96.0%) but outperformed them when restricted to adenomas. Unblinding led to an additional yield of 86 true positive polyp detections (1.1% ADR increase per patient; 73.8% were <5 mm). CADe also increased non-neoplastic polyp detection by an absolute value of 4.9% of the cases (1.8% increase of entire polyp load). Procedure time increased with 6.6±6.5 min (+42.6%). In 22/946 patients, the additional detection of adenomas changed surveillance intervals (2.3%), mostly by increasing the number of small adenomas beyond the cut-off.ConclusionEven if CADe appears to be slightly more sensitive than human endoscopists, the additional gain in ADR was minimal and follow-up intervals rarely changed. Additional inspection of non-neoplastic lesions was increased, adding to the inspection and/or polypectomy workload.

Published
2024
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43. Barrett oesophagus

Author

Peters, Yonne, Al-Kaabi, Ali, Shaheen, Nicholas J., Chak, Amitabh, Blum, Andrew, Souza, Rhonda F., Di Pietro, Massimiliano, Iyer, Prasad G., Pech, Oliver, Fitzgerald, Rebecca C., and Siersema, Peter D.

Published
2019
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48. Wide-area transepithelial sampling with computer-assisted analysis to detect high grade dysplasia and cancer in Barrettʼs esophagus: a multicenter randomized study

Author

van Munster, Sanne N., primary, Leclercq, Philippe, primary, Haidry, Rehan, additional, Messmann, Helmut, additional, Probst, Andreas, additional, Ragunath, Krish, additional, Bhandari, Pradeep, additional, Repici, Alessandro, additional, Munoz-Navas, Miguel, additional, Seewald, Stefan, additional, Lemmers, Arnaud, additional, Fernández-Esparrach, Glòria, additional, Pech, Oliver, additional, Schoon, Erik J., additional, Kariv, Revital, additional, Neuhaus, Horst, additional, Weusten, Bas L. A. M., additional, Siersema, Peter D., additional, Correale, Loredana, additional, Meijer, Sybren L., additional, de Hertogh, Gert, additional, Bergman, Jacques J.G.H.M., additional, Hassan, Cesare, additional, and Bisschops, Raf, additional

Published
2022
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50. S3-Leitlinie Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus.

Author

Porschen, Rainer, Fischbach, Wolfgang, Gockel, Ines, Hollerbach, Stephan, Hölscher, Arnulf, Jansen, Petra Lynen, Miehlke, Stephan, Pech, Oliver, Stahl, Michael, Vanhoefer, Udo, Ebert, Matthias P. A., Baretton, Gustavo, Bostel, Tilmann, Ell, Christian, Goerling, Ute, Grenacher, Lars, Kade, Barbara, Knoefel, Wolfram Trudo, Körber, Jürgen, and Lenz, Philipp

Published
2023
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