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568 results on '"Pecoits-Filho, R."'

2. OC 45.3 Major Bleeding Event Rates in Patients on Hemodialysis and Peritoneal Dialysis: Results from the International DOPPS and PDOPPS

Author

Guedes, M., primary, Zhao, J., additional, Coyle, C., additional, Bash, L., additional, Ramey, D., additional, Atkins, G., additional, Johnson, D., additional, Vega, A., additional, Urena, P., additional, Manuel Ferraro, P., additional, Al Ghonaim, M., additional, Bonaca, M., additional, Pecoits-Filho, R., additional, and Karaboyas, A., additional

Published
2023
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3. WCN23-1055 CONSTIPATION AND CLINICAL OUTCOMES IN PERITONEAL DIALYSIS THAILAND RESULTS FROM PDOPPS

Author

Tharapanich, H., primary, Halue, G., additional, Kanjanabuch, T., additional, Phannajit, J., additional, Lorvinitnun, P., additional, Chieochanthanakij, R., additional, Treamtrakanpon, W., additional, Parinyasiri, U., additional, Lowmseng, N., additional, Songviriyavithaya, P., additional, Johnson, D.W., additional, Perl, J., additional, Pecoits-Filho, R., additional, and Tungsanga, K., additional

Published
2023
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8. Establishing a Core Outcome Measure for Peritoneal Dialysis-related Peritonitis: A Standardized Outcomes in Nephrology-Peritoneal Dialysis Consensus Workshop Report.

Author

Shen J.I., Cho Y., Manera K.E., Brown F., Dong J., Al Sahlawi M., Acevedo R.G., Htay H., Ito Y., Kanjanabuch T., Nessim S.J., Ngaruiya G., Piraino B., Szeto C.-C., Teitelbaum I., Amir N., Craig J.C., Baumgart A., Gonzalez A.M., Viecelli A.K., Wilkie M., Tong A., SONG Executive Committee, Craig J., Wang A., Hemmelgarn B., Manns B., Wheeler D., Gill J., Tugwell P., Pecoits-Filho R., Crowe S., Harris T., Van Biesen W., Winkelmayer W., SONG-PD Steering Group, Johnson D.W., Brown E., Brunier G., Manera K., Mehrotra R., Dunning S.-A., Dunning T., SONG-PD Infection Expert Working Group, Perl J., Szeto C.C., Forfang D., Gomez R., Nessim S., Shen J., SONG Coordinating Committee, Martin A., Bernier-Jean A., Matus Gonzalez A., Viecelli A., Ju A., Teixera-Pinto A., Sautenet B., Hanson C., Guha C., Sumpton D., Hannan E., O'Lone E., Au E., Kerklaan J., Dunn L., Howell M., Nataatmadja M., Evangelidis N., Natale P., Cazzolli R., Anumudu S., Carter S., Gutman T., Rahim Vastani T.V., Participants and contributors - Health professionals, Abu-Alfa A., Matus-Gonzalez A., Aufricht C., Wallace E., Dasgupta I., Knight J., Foo M., Lambie M., Schreiber M., Pisoni R., Apata R., Antwi S., Novosad S., Davies S., Booth S., Participants and contributors - Patients/family members/caregivers, Lau A., Chi A., Heckendorn B., Allen B., Dewey B., Horton D., Edwards D., Robinson E., Franco F., Braddock G., Grossman G., Chestney J., Laws K., Clark K., Penningtown K., Richardson L., Verdin N., Jefferson N., Scholes-Robertson N., Gedney N., Chestney N., Griffiths P., Kidwell S., Downs S., Ball T., Yaeger T., Elly V., Senior W., Shen J.I., Cho Y., Manera K.E., Brown F., Dong J., Al Sahlawi M., Acevedo R.G., Htay H., Ito Y., Kanjanabuch T., Nessim S.J., Ngaruiya G., Piraino B., Szeto C.-C., Teitelbaum I., Amir N., Craig J.C., Baumgart A., Gonzalez A.M., Viecelli A.K., Wilkie M., Tong A., SONG Executive Committee, Craig J., Wang A., Hemmelgarn B., Manns B., Wheeler D., Gill J., Tugwell P., Pecoits-Filho R., Crowe S., Harris T., Van Biesen W., Winkelmayer W., SONG-PD Steering Group, Johnson D.W., Brown E., Brunier G., Manera K., Mehrotra R., Dunning S.-A., Dunning T., SONG-PD Infection Expert Working Group, Perl J., Szeto C.C., Forfang D., Gomez R., Nessim S., Shen J., SONG Coordinating Committee, Martin A., Bernier-Jean A., Matus Gonzalez A., Viecelli A., Ju A., Teixera-Pinto A., Sautenet B., Hanson C., Guha C., Sumpton D., Hannan E., O'Lone E., Au E., Kerklaan J., Dunn L., Howell M., Nataatmadja M., Evangelidis N., Natale P., Cazzolli R., Anumudu S., Carter S., Gutman T., Rahim Vastani T.V., Participants and contributors - Health professionals, Abu-Alfa A., Matus-Gonzalez A., Aufricht C., Wallace E., Dasgupta I., Knight J., Foo M., Lambie M., Schreiber M., Pisoni R., Apata R., Antwi S., Novosad S., Davies S., Booth S., Participants and contributors - Patients/family members/caregivers, Lau A., Chi A., Heckendorn B., Allen B., Dewey B., Horton D., Edwards D., Robinson E., Franco F., Braddock G., Grossman G., Chestney J., Laws K., Clark K., Penningtown K., Richardson L., Verdin N., Jefferson N., Scholes-Robertson N., Gedney N., Chestney N., Griffiths P., Kidwell S., Downs S., Ball T., Yaeger T., Elly V., and Senior W.

Abstract

Introduction: Peritoneal dialysis (PD)-related peritonitis is one of the leading causes of discontinuation of PD and is considered a critically important outcome for patients on PD. However, there is no universally accepted method of measuring this outcome in clinical trials. Method(s): We convened an online consensus workshop to establish a core outcome measure for PD-related peritonitis in clinical trials. Result(s): A total of 53 participants, including 18 patients and caregivers, from 12 countries engaged in breakout discussions in this workshop. Transcripts were analyzed thematically. We identified the following 3 themes: (i) feasibility and applicability across diverse settings, which reflected the difficulty with implementing laboratory-based measures in resource-limited environments; (ii) ensuring validity, which included minimizing false positives and considering the specificity of symptoms; and (iii) being meaningful and tangible to patients, which meant that the measure should be easy to interpret, reflect the impact that symptoms have on patients, and promote transparency by standardizing the reporting of peritonitis among dialysis units. Conclusion(s): A core outcome measure for PD-related peritonitis should include both symptom-based and laboratory-based criteria. Thus, the International Society for Peritoneal Dialysis (ISPD) definition of peritonitis is acceptable. However, there should be consideration of reporting suspected peritonitis in cases where laboratory confirmation is not possible. The measure should include all infections from the time of catheter insertion and capture both the rate of infection and the number of patients who remain peritonitis free. A core outcome measure with these features would increase the impact of clinical trials on the care and decision-making of patients receiving PD.Copyright © 2022 International Society of Nephrology

Published
2022

9. Risk factors for incident kidney disease in older adults: an Australian prospective population-based study.

Author

Kang, A, Sukkar, L, Hockham, C, Jun, M, Young, T, Scaria, A, Foote, C, Neuen, BL, Cass, A, Pollock, C, Comino, E, Lung, T, Pecoits-Filho, R, Rogers, K, Jardine, MJ, EXTEND45 Study Steering Committee†, Kang, A, Sukkar, L, Hockham, C, Jun, M, Young, T, Scaria, A, Foote, C, Neuen, BL, Cass, A, Pollock, C, Comino, E, Lung, T, Pecoits-Filho, R, Rogers, K, Jardine, MJ, and EXTEND45 Study Steering Committee†

Abstract

BACKGROUND AND AIM: To determine risk factors for incident chronic kidney disease (CKD) in a large population-based cohort. METHODS: This prospective opt-in population-based cohort study is based on the 45 and Up Study, where New South Wales residents aged ≥45 years were randomly sampled from the Services Australia database and agreed to complete the 45 and Up Study baseline questionnaire and have their responses linked to their health data in routinely collected databases. The primary outcome was the development of incident CKD, defined as eGFR < 60 mL/min/1.73 m2 . CKD incidence was calculated using Poisson regression. Risk factors for incident CKD were assessed using Cox regression in multivariable models. RESULTS: In 39 574 participants who did not have CKD at enrolment, independent factors associated with developing CKD included: older age, regional residence (HR 1.38 (1.27-1.50) for outer regional vs major city), smoking (1.13 (1.00-1.27) for current smoker vs non-smoker), obesity (1.25 (1.16-1.35) for obese vs normal body mass index), diabetes mellitus (1.41 (1.33-1.50)), hypertension (1.53 (1.44-1.62)), coronary heart disease (1.13 (1.07-1.20)), depression/anxiety (1.16 (1.09-1.24)) and cancer (1.29 (1.20-1.39)). Migrants were less likely to develop CKD compared with people born in Australia (0.88 (0.83-0.94)). Gender, partner status and socioeconomic factors were not independently associated with developing CKD. CONCLUSIONS: This large population-based study found multiple modifiable and non-modifiable factors were independently associated with developing CKD. In the Australian setting, the risk of CKD was higher with regional residence. Differences according to socioeconomic status were predominantly explained by age, comorbidities and harmful health-related behaviours.

Published
2022

10. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

Author

Perkovic, V., Jardine, M. J., Neal, B., Bompoint, S., Heerspink, H. J. L., Charytan, D. M., Edwards, R., Agarwal, R., Bakris, G., Bull, S., Cannon, C. P., Capuano, G., Chu, P. -L., De Zeeuw, D., Greene, T., Levin, A., Pollock, C., Wheeler, D. C., Yavin, Y., Zhang, H., Zinman, B., Meininger, G., Brenner, B. M., Mahaffey, K. W., Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M, Morren, F, Goykhman, S, David, C, Yost, L, Wang, H, Hettiarachchi, M, Thimmaiah, R, Koppolu, D, George, S, Schmidt, M, Ignjatovic, J, Chapin, L, Travis, K, Destree, M, Sood, V, Coffee, L, De Brouwer, K, Zaviriukha, V, Starzec, A, Koizumi, M, Lin, G, Chen, E, Lin, P, Leia, C, Mascaro, D, Amigo, A, Limos, A, Abrahamsen, I, Jaffer, S, Ahuad Guerrero RA, Albisu, Jp, Alvarisqueta, A, Bartolacci, I, Berli, Ma, Bordonava, A, Calella, P, Cantero, Mc, Cartasegna, Lr, Cercos, E, Coloma, Gc, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, Ca, Cusumano, Am, Douthat, Wg, Dran, Rd, Farias, E, Fernandez, Mf, Finkelstein, H, Fragale, G, Fretes, Jo, Garcia, Nh, Gastaldi, A, Gelersztein, E, Glenny, Ja, Gonzalez, Jp, Gonzalez Colaso PDC, Goycoa, C, Greloni, Gc, Guinsburg, A, Hermida, S, Juncos, Li, Klyver, Mi, Kraft, F, Krynski, F, Lanchiotti, Pv, Leon de la Fuente RA, Marchetta, N, Mele, P, Nicolai, S, Novoa, Pa, Orio, Si, Otreras, F, Oviedo, A, Raffaele, P, Resk, Jh, Rista, L, Rodriguez Papini, N, Sala, J, Santos, Jc, Schiavi, Lb, Sessa, H, Smith Casabella, T, Ulla, Mr, Valdez, M, Vallejos, A, Villarino, A, Visco, Ve, Wassermann, A, Zaidman, Cj, Cheung, Nw, Droste, C, Fraser, I, Johnson, D, Mah, Pm, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, Ra, Alves da Costa FA, Amodeo, C, Andreotti Turatti LA, Bregman, R, Camelo Sanches FC, Canani, Lh, Chacra, Ar, Cunha Borges JL, Cunha Vêncio SA, da Silva Franco RJ, D'Avila, D, de Souza Portes, E, de Souza, P, Deboni, Lm, Filho, Ff, Geloneze Neto, B, Gomes, M, Kohara, Sk, Keitel, E, Kerr Saraiva JF, Kurtz Lisboa HR, de Carvalho Contieri FL, Milagres, R, Montenegro Junior, R, Moreira de Brito, C, Nazzer Hissa, M, Nazario Sabbag ÂR, Noronha, I, Panarotto, D, Pecoits Filho, R, Pereira, Ma, Saporito, W, Scotton, As, Schuch, T, Simões de Almeida, R, Slompo Ramos, C, Soares Felício, J, Thomé, F, Tibes Hachmann JC, Yamada, S, Yoiti Hayashida, C, Zanata Petry TB, Zanella, Mt, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A, Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Chouinard, G, Conway, J, Cournoyer, S, Daroza, G, De Serres, S, Dubé, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, Mcmahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, N, Fernández Montenegro MA, Godoy Jorquera JG, Medina Fariña, M, Saavedra Gajardo, V, Vejar, M, Chen, N, Chen, Q, Gan, S, Kong, Y, Li, D, Li, W, Li, X, Lin, H, Liu, J, Lu, W, Mao, H, Ren, Y, Song, W, Sun, J, Sun, L, Tu, P, Wang, G, Yang, J, Yin, A, Yu, X, Zhao, M, Zheng, H, Accini Mendoza JL, Arcos, E, Avendano, J, Diaz Ruiz JEA, Garcia Ortiz LH, Gonzalez, A, Hernandez Triana, E, Higuera, Jd, Malaver, N, Molina de Salazar DI, Rosero, R, Terront Lozano MA, Valderrama Cometa, L, Valenzuela, A, Vargas Alonso RD, Villegas, I, Yupanqui, H, Bartaskova, D, Barton, P, Belobradkova, J, Dohnalova, L, Drasnar, T, Ferkl, R, Halciakova, K, Klokocnikova, V, Kovar, R, Lastuvka, J, Lukac, M, Pesickova, S, Peterka, K, Pumprla, J, Rychlik, I, Saudek, F, Tesar, V, Valis, M, Weiner, P, Zemek, S, Alamartine, E, Borot, S, Cariou, B, Dussol, B, Fauvel, Jp, Gourdy, P, Klein, A, Le Meur, Y, Penfornis, A, Roussel, R, Saulnier, Pj, Thervet, E, Zaoui, P, Burst, V, Faghih, M, Faulmann, G, Haller, H, Jerwan-Keim, R, Maxeiner, S, Paschen, B, Plassmann, G, Rose, L, Gonzalez Orellana RA, Haase, Fp, Moreira Diaz JP, Ramirez Roca LA, Sánchez Arenales JA, Sanchez Polo JV, Turcios Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Abraham, O, Bhushan, Rs, Deepak, D, Edwin, Fm, Gopalakrishnan, N, Gracious, N, Hansraj, A, Jain, D, Keshavamurthy, Cb, Khullar, D, Manisha, S, Peringat, J, Prasad, N, Satyanarayana, Rk, Sreedhar, R, Sreelatha, M, Sudhakar, B, Vyasam, Rc, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, Derosa, G, Di Carlo, A, Di Cianni, G, Frascà, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, Fc, Serviddio, G, Stella, A, Trevisan, R, Veronelli, Am, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T, Kajiyama, S, Kashine, S, Kawada, T, Kodera, T, Kono, H, Koyama, K, Kumeda, Y, Miyauchi, S, Mizuyama, K, Niiya, T, Oishi, H, Ota, S, Sakakibara, T, Takai, M, Tomonaga, O, Tsujimoto, M, Wakasugi, M, Wakida, Y, Watanabe, T, Yamada, M, Yanagida, K, Yanase, T, Yumita, W, Gaupsiene, E, Kozloviene, D, Navickas, A, Urbanaviciene, E, Abdul Ghani, R, Abdul Kadir, K, Ali, N, Che Yusof MD, Gan, Cl, Ismail, M, Kong, Wy, Lam, Sw, Lee, Ly, Loh, Cl, Manocha, Ab, Ng, Ks, Nik Ahmad NNF, Ratnasingam, V, Bin Shudim SS, Vengadasalam, P, Abraira Munoz LD, Salazar, Ma, Cruz, Jb, Soto, Mb, Ramos, Jc, Wong, Ac, Correa Rotter JR, Diaz Escalante, T, Enriquez Sosa FE, Flores Lozano, F, Flota Cervera LF, Frenk Baron, P, Garcia Ballesteros, C, Gomez Rangel JD, Herrera Jimenez LE, Irizar Santana SS, Jimenez Florez, F, Laviada Molina, H, Luna Ceballos RI, Martin Del Camp Blanco, B, Morales Franco, G, Moreno Loza OT, Mustieles Rocha, C, Obrador Vera, G, Orozco Castellanos, R, Peralta Calcaneo, J, Reyes Rosano MA, Rodriguez Pattzi, H, Rosas Guzman, J, Rucker Joerg IE, Saaveddra Sanchez SB, Sanchez Mijangos JH, Serrano Sanson, P, Tamayo, Y Orozco JA, Tellez Chavez, E, Valdes Depeda, A, Venegas Carrillo, L, Villagordoa Mesa, J, Zamarripa Escobedo, R, Baker, J, Noonan, P, Scott, R, Walker, R, Watson, E, Williams, M, Young, S, Abejuela, Z, Agra, J, Aquitania, G, Caringal, C, Comia, Rs, Delos Santos, L, Gomez, O, Jimeno, C, Tan, G, Tolentino, M, Yao, C, Yap, Ye, Ygpuara, Mdl, Bijata-Bronisz, R, Hotlos, L, Januszewicz, A, Kaczmarek, B, Kaminska, A, Lazuka, L, Madej, A, Mazur, S, Mlodawska-Choluj, D, Orlowska-Kowalik, G, Popenda, G, Rewerska, B, Sowinski, D, Angelescu, Lm, Anghel, V, Avram, Ri, Busegeanu, Mm, Cif, A, Cosma, D, Crisan, C, Demian, Ld, Ferariu, Ie, Halmagyi, I, Hancu, N, Munteanu, M, Negru, D, Onaca, Ag, Petrica, L, Popa, Ar, Ranetti, Ae, Serafinceanu, C, Toarba, C, Agafyina, A, Barbarash, O, Barysheva, O, Chizhov, D, Dobronravov, V, Glinkina, I, Grineva, E, Khirmanov, V, Kolmakova, E, Koroleva, T, Kvitkova, L, Marasaev, V, Mkrtumyan, A, Morugova, T, Nagibovich, G, Nagibovich, O, Nedogoda, S, Osipova, I, Raskina, T, Samoylova, Y, Sazonova, O, Shamkhalova, M, Shutemova, E, Shwartz, Y, Uriasyev, O, Vorobyev, S, Zateyshchikova, A, Zateyshshikov, D, Zykova, T, Antic, S, Djordjevic, M, Kendereski, A, Lalic, K, Lalic, N, Popovic-Radinovic, V, Babikova, J, Benusova, O, Buganova, I, Culak, J, Dzupina, A, Dzuponova, J, Fulop, P, Ilavska, A, Martinka, E, Ochodnicka, Z, Pella, D, Smatanova, I, Ahmed, F, Badat, A, Breedt, J, Govender, V, Govender, R, Joshi, M, Jurgens, J, Latiff, G, Lombard, L, Mookadam, M, Ngcakani, N, Nortje, H, Oosthuizen, H, Pillay-Ramaya, L, Prozesky, H, Reddy, J, Rheeder, P, Seeber, M, Cho, Ym, Jeong, Ik, Kim, Sg, Kim, Yh, Kwon, Hs, Kwon, Mj, Lee, Bw, Lee, J, Lee, Mk, Nam, Ms, Oh, Kh, Park, Cy, Park, Sh, Yoon, Kh, Alvarez Garcia, P, Asmarats Mercadal, L, Barrios, C, Cereto Castro, F, Cigarran Guldris, S, Dominquez Lopez, M, Egido de Los Rios, J, Fernandez Fresnedo, G, Galan Serrano, A, Garcia, I, Gonzalez Martinez FJ, Jodar Gimeno JE, Muñoz Lopez Mendoza, M, Malek Marin, T, Morales Portillo, C, Munar Vila MA, Muñoz Torres, M, Nieto Iglesias, J, Pantoja Perez, J, Perez Vera, M, Portoles Perez JM, Quesada Simón MA, Simo Canonge, R, Soto Gonzalez, A, Terns Riera, M, Tinahones Madueno FJ, Plaza, Mv, Chang, Ct, Chuang, Lm, Hsia, Tl, Hsieh, Ch, Lin, Cc, Lu, Yc, Sheu, Wh, Barna, O, Bilyk, Sd, Botsyurko, V, Dudar, I, Fushtey, I, Godlevska, O, Golovchenko, O, Gyrina, O, Kazmirchuk, A, Komisarenko, I, Korzh, O, Kravchun, N, Legun, O, Mankovskyy, B, Martynyuk, L, Mostovoy, Y, Pashkovska, N, Pererva, L, Pertseva, T, Samoylov, O, Smirnov, I, Svyshchenko, Y, Tomashkevych, H, Topchii, I, Tryshchuk, N, Tseluyko, V, Vizir, V, Vlasenko, M, Zlova, T, Zub, L, Abusnana, S, Railey, M, Abouglila, K, Ainsworth, P, Ali, Z, Arutchelvam, V, Barnard, M, Bellary, S, Davies, E, Davies, M, Davies, S, Dawson, A, El Kossi, M, English, P, Fraser, D, Gnudi, L, Gunstone, A, Hall, T, Hanif, W, Jackson, A, Johnson, A, Joseph, F, Krishnan, S, Kumwenda, M, Macdougall, I, Nixon, P, O'Hare, J, Philip, S, Ramtoola, S, Saxena, M, Sennik, D, Simon, G, Singh, B, Stephens, J, Strzelecka, A, Symonds, R, Turner, W, Wahba, M, Wakeling, J, Wheeler, D, Winocour, P, Abdallah, J, Abdullah, R, Abramowitz, M, Acosta, I, Aiello, J, Akright, L, Akyea-Djamson, A, Alappan, R, Alicic, R, Al-Karadsheh, A, Allison, Dc, Arauz-Pacheco, C, Arfeen, S, Arif, A, Arvind, M, Atray, N, Awad, A, Barnhill, P, Barranco, E, Barrera, C, Beacom, M, Behara, V, Belo, D, Bentley-Lewis, R, Berenguer, R, Bermudez, L, Bernardo, M, Biscoveanu, M, Bowman-Stroud, C, Brandon, D, Brusco, O, Busch, R, Canaan, Y, Chilito, A, Christensen, T, Christiano, C, Christofides, E, Chuateco, C, Cohen, K, Cohen, R, Cohen-Stein, D, Cook, C, Coyne, D, Daboul, N, Darwish, R, Daswani, A, Deck, K, Desouza, C, Dev, D, Dhillon, M, Dua, S, Eder, F, Elosegui, Am, El-Shahawy, M, Ervin, J, Esquenazi, A, Evans, J, Fishbane, S, Frias, J, Galindo-Ramos, E, Galphin, C, Ghazi, A, Gonzalez, E, Gorson, D, Gowda, A, Greco, B, Grubb, S, Gulati, R, Hammoud, J, Handelsman, S, Hartman, I, Hershon, K, Hiser, D, Hon, G, Jacob, R, Jaime, M, Jamal, A, Kaupke, C, Keightley, G, Kern, E, Khanna, R, Khitan, Z, Kim, S, Kopyt, N, Kovesdy, C, Krishna, G, Kropp, J, Kumar, A, Kumar, J, Kumar, N, Kusnir, J, Lane, W, Lawrence, M, Lehrner, L, Lentz, J, Levinson, D, Lewis, D, Liss, K, Maddux, A, Maheshwari, H, Mandayam, S, Marar, I, Mehta, B, Middleton, J, Mordujovich, J, Moreda, R, Moustafa, M, Mujica Trenche, S, Narayanan, M, Narvarte, J, Nassar, T, Newman, G, Nichol, B, Nicol, P, Nisnisan, J, Nossuli, Ak, Obialo, C, Olelewe, S, Oliver, M, O'Shaughnessy, A, Padron, J, Pankhaniya, R, Parker, R, Patel, D, Patel, G, Patel, N, Pavon, H, Perez, A, Perez, C, Perlman, A, Pettis, K, Pharr, W, Phillips, A, Purighalla, R, Quesada-Suarez, L, Ranjan, R, Rastogi, S, Rendell, M, Rich, L, Robinson, M, Rodriguez, H, Rosas, S, Saba, F, Sankaram, R, Sarin, R, Schreiman, R, Scott, D, Sekkarie, M, Sensenbrenner, J, Shakeel, M, Shanik, M, Shaw, S, Smith, S, Solomon, R, Sprague, A, Spry, L, Suchinda, P, Sultan, S, Surampudi, P, Sussman, S, Tan, A, Terrelonge, A, Thompson, M, Trespalacios, F, Trippe, B, Trueba, P, Twahirwa, M, Updegrove, J, Van Buren, P, Vannorsdall, M, Varghese, F, Velasquez-Mieyer, P, Ventrapragada, S, Vukotic, G, Wadud, K, Warren, M, Watson, H, Watts, R, Weiner, D, Welker, J, Welsh, J, Williams, S, Zaniewski-Singh, M., Perkovic, Vlado, Jardine, Meg J, Neal, Bruce, Bompoint, Severine, Heerspink, Hiddo J L, Charytan, David M, Edwards, Robert, Agarwal, Rajiv, Bakris, George, Bull, Scott, Cannon, Christopher P, Capuano, George, Chu, Pei-Ling, de Zeeuw, Dick, Greene, Tom, Levin, Adeera, Pollock, Carol, Wheeler, David C, Yavin, Yshai, Zhang, Hong, Zinman, Bernard, Meininger, Gary, Brenner, Barry M, Mahaffey, Kenneth W, collaborator: Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M, Morren, F, Goykhman, S, David, C, Yost, L, Wang, H, Hettiarachchi, M, Thimmaiah, R, Koppolu, D, George, S, Schmidt, M, Ignjatovic, J, Chapin, L, Travis, K, Destree, M, Sood, V, Coffee, L, De Brouwer, K, Zaviriukha, V, Starzec, A, Koizumi, M, Lin, G, Chen, E, Lin, P, Leia, C, Mascaro, D, Amigo, A, Limos, A, Abrahamsen, I, Jaffer, S, Ahuad Guerrero, Ra, Albisu, Jp, Alvarisqueta, A, Bartolacci, I, Berli, Ma, Bordonava, A, Calella, P, Cantero, Mc, Cartasegna, Lr, Cercos, E, Coloma, Gc, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, Ca, Cusumano, Am, Douthat, Wg, Dran, Rd, Farias, E, Fernandez, Mf, Finkelstein, H, Fragale, G, Fretes, Jo, Garcia, Nh, Gastaldi, A, Gelersztein, E, Glenny, Ja, Gonzalez, Jp, Gonzalez Colaso, Pdc, Goycoa, C, Greloni, Gc, Guinsburg, A, Hermida, S, Juncos, Li, Klyver, Mi, Kraft, F, Krynski, F, Lanchiotti, Pv, Leon de la Fuente, Ra, Marchetta, N, Mele, P, Nicolai, S, Novoa, Pa, Orio, Si, Otreras, F, Oviedo, A, Raffaele, P, Resk, Jh, Rista, L, Rodriguez Papini, N, Sala, J, Santos, Jc, Schiavi, Lb, Sessa, H, Smith Casabella, T, Ulla, Mr, Valdez, M, Vallejos, A, Villarino, A, Visco, Ve, Wassermann, A, Zaidman, Cj, Cheung, Nw, Droste, C, Fraser, I, Johnson, D, Mah, Pm, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, Ra, Alves da Costa, Fa, Amodeo, C, Andreotti Turatti, La, Bregman, R, Camelo Sanches, Fc, Canani, Lh, Chacra, Ar, Cunha Borges, Jl, Cunha Vêncio, Sa, da Silva Franco, Rj, D'Avila, D, de Souza Portes, E, de Souza, P, Deboni, Lm, Filho, Ff, Geloneze Neto, B, Gomes, M, Kohara, Sk, Keitel, E, Kerr Saraiva, Jf, Kurtz Lisboa, Hr, de Carvalho Contieri, Fl, Milagres, R, Montenegro Junior, R, Moreira de Brito, C, Nazzer Hissa, M, Nazario Sabbag, Âr, Noronha, I, Panarotto, D, Pecoits Filho, R, Pereira, Ma, Saporito, W, Scotton, A, Schuch, T, Simões de Almeida, R, Slompo Ramos, C, Soares Felício, J, Thomé, F, Tibes Hachmann, Jc, Yamada, S, Yoiti Hayashida, C, Zanata Petry, Tb, Zanella, Mt, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A, Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Chouinard, G, Conway, J, Cournoyer, S, Daroza, G, De Serres, S, Dubé, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, Mcmahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, N, Fernández Montenegro, Ma, Godoy Jorquera, Jg, Medina Fariña, M, Saavedra Gajardo, V, Vejar, M, Chen, N, Chen, Q, Gan, S, Kong, Y, Li, D, Li, W, Li, X, Lin, H, Liu, J, Lu, W, Mao, H, Ren, Y, Song, W, Sun, J, Sun, L, Tu, P, Wang, G, Yang, J, Yin, A, Yu, X, Zhao, M, Zheng, H, Accini Mendoza, Jl, Arcos, E, Avendano, J, Diaz Ruiz, Jea, Garcia Ortiz, Lh, Gonzalez, A, Hernandez Triana, E, Higuera, Jd, Malaver, N, Molina de Salazar, Di, Rosero, R, Terront Lozano, Ma, Valderrama Cometa, L, Valenzuela, A, Vargas Alonso, Rd, Villegas, I, Yupanqui, H, Bartaskova, D, Barton, P, Belobradkova, J, Dohnalova, L, Drasnar, T, Ferkl, R, Halciakova, K, Klokocnikova, V, Kovar, R, Lastuvka, J, Lukac, M, Pesickova, S, Peterka, K, Pumprla, J, Rychlik, I, Saudek, F, Tesar, V, Valis, M, Weiner, P, Zemek, S, Alamartine, E, Borot, S, Cariou, B, Dussol, B, Fauvel, Jp, Gourdy, P, Klein, A, Le Meur, Y, Penfornis, A, Roussel, R, Saulnier, Pj, Thervet, E, Zaoui, P, Burst, V, Faghih, M, Faulmann, G, Haller, H, Jerwan-Keim, R, Maxeiner, S, Paschen, B, Plassmann, G, Rose, L, Gonzalez Orellana, Ra, Haase, Fp, Moreira Diaz, Jp, Ramirez Roca, La, Sánchez Arenales, Ja, Sanchez Polo, Jv, Turcios Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Abraham, O, Bhushan, R, Deepak, D, Edwin, Fm, Gopalakrishnan, N, Gracious, N, Hansraj, A, Jain, D, Keshavamurthy, Cb, Khullar, D, Manisha, S, Peringat, J, Prasad, N, Satyanarayana, Rk, Sreedhar, R, Sreelatha, M, Sudhakar, B, Vyasam, Rc, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, Derosa, G, Di Carlo, A, Di Cianni, G, Frascà, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, Fc, Serviddio, G, Stella, A, Trevisan, R, Veronelli, Am, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T et al, Groningen Kidney Center (GKC), and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)

Subjects
Aged, Canagliflozin, Cardiovascular Diseases, Creatinine, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Double-Blind Method, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic, Male, Middle Aged, Sodium-Glucose Transporter 2 Inhibitors, Type 2 diabetes, 030204 cardiovascular system & hematology, Diabetic nephropathy, Kidney Failure, chemistry.chemical_compound, 0302 clinical medicine, 030212 general & internal medicine, 03.02. Klinikai orvostan, Dapagliflozin, Chronic, 11 Medical and Health Sciences, EMPAGLIFLOZIN, General Medicine, Life Sciences & Biomedicine, Type 2, medicine.drug, medicine.medical_specialty, Nephropathy, 03 medical and health sciences, Medicine, General & Internal, Internal medicine, Diabetes mellitus, General & Internal Medicine, CREDENCE Trial Investigators, medicine, Diabetes Mellitus, Science & Technology, business.industry, urogenital system, diabetic nephropathy, Type 2 Diabetes Mellitus, KIDNEY-DISEASE, medicine.disease, chemistry, business, Kidney disease
Abstract

BACKGROUND: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin-angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of

Published
2019

11. High sodium intake is associated with important risk factors in a large cohort of chronic kidney disease patients

Author

Nerbass, F.B., Pecoits-Filho, R., McIntyre, N.J., McIntyre, C.W., and Taal, M.W.

Subjects
Sodium (Nutrient) -- Health aspects, Chronic kidney failure -- Risk factors, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: An Increased risk of mortality and cardiovascular disease (CVD) Is observed In people with chronic kidney disease (CKD) even in early stages. Dietary sodium intake has been associated with important CVD and CKD progression risk factors such as hypertension and proteinuria in this population. We aimed to investigate the relationship between sodium intake and CVD or CKD progression risk factors in a large cohort of patients with CKD stage 3 recruited from primary care. SUBJECTS/METHODS: A total of 1733 patients with previous estimated glomerular filtration rate (eGFR) of 30-59 ml/min/1.73[m.sup.2], with a mean age 72.9 [+ or -] 9.0 years, were recruited from 32 general practices in primary care in England. Medical history was obtained and participants underwent clinical assessment, urine and serum biochemistry testing. Sodium intake was estimated from three early-morning urine specimens using an equation validated for this study population. RESULTS: Sixty percent of participants who had estimated sodium intake above recommendation (>100 mmol/day or 6 g salt/day) also had higher diastolic blood pressure, mean arterial pressure (MAP), urinary albumin-to-creatinine ratio, high- sensitive C-reactive protein and uric acid and used a greater number of anti-hypertensive drugs. In multivariable regression analysis, excessive sodium intake was an independent predictor of MAP (B = 1.57, 95% confidence interval (CI) 0.41-2.72; P = 0.008) and albuminuria (B = 1.35, 95% CI 1.02-1.79; P = 0.03). CONCLUSIONS: High sodium intake was associated with CVD and CKD progression risk factors in patients with predominantly early stages of CKD followed up in primary care. This suggests that dietary sodium intake could afffect CVD risk even in early or mild CKD. Intervention studies are warranted to investigate the potential benefit of dietary advice to reduce sodium intake in this population. European Journal of Clinical Nutrition (2015) 69, 786-790; doi:10.1038/ejcn.2014.215; published online 8 October 2014, INTRODUCTION People with chronic kidney disease (CKD) are at an increased risk of mortality, and cardiovascular disease (CVD) is the leading cause of premature death. (1,2) The increase in risk [...]

Published
2015
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13. POS-305 HOSPITALIZATIONS AND LENGTH OF STAY IN PATIENTS WITH CKD WITH AND WITHOUT HYPERKALEMIA: A REPORT FROM THE DISCOVER CKD RETROSPECTIVE COHORT

Author

James, G., primary, Carrero, J.J., additional, Khezrian, M., additional, Fishbane, S., additional, Wittbrodt, E., additional, Kanda, E., additional, Chen, H., additional, Kashihara, N., additional, Järbrink, K., additional, Lam, C.S.P., additional, Pollock, C., additional, Lainscak, M., additional, Stenvinkel, P., additional, Wheeler, D.C., additional, and Pecoits-Filho, R., additional

Published
2022
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14. POS-968 COVID-19 PANDEMIC IDENTIFIES SIGNIFICANT GLOBAL INEQUITIES IN HEMODIALYSIS CARE IN LOW AND LOWER MIDDLE INCOME COUNTRIES - AN ISN/DOPPS SURVEY

Author

Tannor, E.K., primary, BIEBER, B., additional, Luyckx, V., additional, Shah, D.S., additional, Liew, A., additional, Evans, R., additional, Aylward, R., additional, Guedes, M., additional, Pisoni, R.L., additional, Robinson, B.M., additional, Caskey, F., additional, Jha, V., additional, Pecoits-Filho, R., additional, and Dreyer, G., additional

Published
2022
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15. POS-926 IN-CENTRE HAEMODIALYSIS CENTRES VARIABLY AFFECTED BY THE CORONAVIRUS-2019 PANDEMIC IN DIFFERENT REGIONS OF THE WORLD: THE INTERNATIONAL SOCIETY OF NEPHROLOGY-DIALYSIS OUTCOMES PRACTICE PATTERNS STUDY SURVEY

Author

AYLWARD, R., primary, BIEBER, B., additional, Guedes, M., additional, Pisoni, R., additional, Koranteng Tannor, E., additional, Dreyer, G., additional, Liew, A., additional, Luyckx, V., additional, Singh, D., additional, Phiri, C., additional, Evans, R., additional, Jha, V., additional, Pecoits-Filho, R., additional, Robinson, B., additional, and Caskey, F., additional

Published
2022
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16. Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Cheung, A, Chang, T, Cushman, W, Furth, S, Ix, J, Pecoits-Filho, R, Perkovic, V, Sarnak, M, Tobe, S, Tomson, C, Cheung, M, Wheeler, D, Winkelmayer, W, Mann, J, Bakris, G, Damasceno, A, Dwyer, J, Fried, L, Haynes, R, Hirawa, N, Holdaas, H, Ibrahim, H, Ingelfinger, J, Iseki, K, Khwaja, A, Kimmel, P, Kovesdy, C, Ku, E, Lerma, E, Luft, F, Lv, J, Mcfadden, C, Muntner, P, Myers, M, Navaneethan, S, Parati, G, Peixoto, A, Prasad, R, Rahman, M, Rocco, M, Rodrigues, C, Roger, S, Stergiou, G, Tomlinson, L, Tonelli, M, Toto, R, Tsukamoto, Y, Walker, R, Wang, A, Wang, J, Warady, B, Whelton, P, Williamson, J, Cheung A. K., Chang T. I., Cushman W. C., Furth S. L., Ix J. H., Pecoits-Filho R., Perkovic V., Sarnak M. J., Tobe S. W., Tomson C. R. V., Cheung M., Wheeler D. C., Winkelmayer W. C., Mann J. F. E., Bakris G. L., Damasceno A., Dwyer J. P., Fried L. F., Haynes R., Hirawa N., Holdaas H., Ibrahim H. N., Ingelfinger J. R., Iseki K., Khwaja A., Kimmel P. L., Kovesdy C. P., Ku E., Lerma E. V., Luft F. C., Lv J., McFadden C. B., Muntner P., Myers M. G., Navaneethan S. D., Parati G., Peixoto A. J., Prasad R., Rahman M., Rocco M. V., Rodrigues C. I. S., Roger S. D., Stergiou G. S., Tomlinson L. A., Tonelli M., Toto R. D., Tsukamoto Y., Walker R., Wang A. Y. -M., Wang J., Warady B. A., Whelton P. K., Williamson J. D., Cheung, A, Chang, T, Cushman, W, Furth, S, Ix, J, Pecoits-Filho, R, Perkovic, V, Sarnak, M, Tobe, S, Tomson, C, Cheung, M, Wheeler, D, Winkelmayer, W, Mann, J, Bakris, G, Damasceno, A, Dwyer, J, Fried, L, Haynes, R, Hirawa, N, Holdaas, H, Ibrahim, H, Ingelfinger, J, Iseki, K, Khwaja, A, Kimmel, P, Kovesdy, C, Ku, E, Lerma, E, Luft, F, Lv, J, Mcfadden, C, Muntner, P, Myers, M, Navaneethan, S, Parati, G, Peixoto, A, Prasad, R, Rahman, M, Rocco, M, Rodrigues, C, Roger, S, Stergiou, G, Tomlinson, L, Tonelli, M, Toto, R, Tsukamoto, Y, Walker, R, Wang, A, Wang, J, Warady, B, Whelton, P, Williamson, J, Cheung A. K., Chang T. I., Cushman W. C., Furth S. L., Ix J. H., Pecoits-Filho R., Perkovic V., Sarnak M. J., Tobe S. W., Tomson C. R. V., Cheung M., Wheeler D. C., Winkelmayer W. C., Mann J. F. E., Bakris G. L., Damasceno A., Dwyer J. P., Fried L. F., Haynes R., Hirawa N., Holdaas H., Ibrahim H. N., Ingelfinger J. R., Iseki K., Khwaja A., Kimmel P. L., Kovesdy C. P., Ku E., Lerma E. V., Luft F. C., Lv J., McFadden C. B., Muntner P., Myers M. G., Navaneethan S. D., Parati G., Peixoto A. J., Prasad R., Rahman M., Rocco M. V., Rodrigues C. I. S., Roger S. D., Stergiou G. S., Tomlinson L. A., Tonelli M., Toto R. D., Tsukamoto Y., Walker R., Wang A. Y. -M., Wang J., Warady B. A., Whelton P. K., and Williamson J. D.

Abstract

In September 2017, KDIGO (Kidney Disease: Improving Global Outcomes) convened a Controversies Conference titled Blood Pressure in Chronic Kidney Disease (CKD). The purpose of the meeting was to consider which recommendations from the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKD should be reevaluated based on new evidence from clinical trials. Participants included a multidisciplinary panel of clinical and scientific experts. Discussions focused on the optimal means for measuring blood pressure (BP) as well as managing BP in CKD patients. Consistent with the 2012 Guideline, the conference did not address BP management in patients on maintenance dialysis.

Published
2019

17. Effect of hepatitis C serology on C-reactive protein in a cohort of Brazilian hemodialysis patients

Author

Nascimento M.M., Bruchfeld A., Suliman M.E., Hayashi S.Y., Pecoits-Filho R., Manfro R.C., Pachaly M.A., Renner L., Stenvinkel P., Riella M.C., and Lindholm B.

Subjects
Hepatitis C, C-reactive protein, Interleukin-6, Hemodialysis, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

Hepatitis C (HCV) is not an uncommon feature in hemodialysis (HD) patients and may be a cause of systemic inflammation. Plasma cytokine interleukin-6 (IL-6) is mainly produced by circulating and peripheral cells and induces the hepatic synthesis of C-reactive protein (CRP), which is the main acute phase reactant. The aim of this study was to investigate the influence of HCV on two markers of systemic inflammation, serum CRP and IL-6, in HD patients. The study included 118 HD patients (47% males, age 47 ± 13 years, 9% diabetics) who had been treated by standard HD for at least 6 months. The patients were divided into two groups depending on the presence (HCV+) or absence (HCV-) of serum antibodies against HCV. Serum albumin (S-Alb), plasma high sensitivity CRP (hsCRP), IL-6, and alanine aminotransferase (ALT) were measured and the values were compared with those for 22 healthy controls. Median hsCRP and IL-6 values and hsCRP/IL-6 ratio were: 3.5 vs 2.1 mg/l, P < 0.05; 4.3 vs 0.9 pg/ml, P < 0.0001, and 0.8 vs 2.7, P < 0.0001, for patients and controls, respectively. Age, gender, S-Alb, IL-6 and hsCRP did not differ between the HCV+ and HCV- patients. However, HCV+ patients had higher ALT (29 ± 21 vs 21 ± 25 IU/l) and had been on HD for a longer time (6.1 ± 3.0 vs 4.0 ± 2.0 years, P < 0.0001). Moreover, HCV+ patients had a significantly lower median hsCRP/IL-6 ratio (0.7 vs 0.9, P < 0.05) compared to the HCV- group. The lower hsCRP/IL-6 ratio in HCV+ patients than in HCV- patients suggests that hsCRP may be a less useful marker of inflammation in HCV+ patients and that a different cut-off value for hsCRP for this population of patients on HD may be required to define inflammation.

Published
2005

21. PUK4 General Practitioner Utilization and Costs of Chronic Kidney Disease According to the 2012 KDIGO CKD Classification: A Report from the DISCOVER CKD Retrospective Cohort

Author

Garcia Sanchez, J.J., primary, Arnold, M., additional, Carrero, J.J., additional, James, G., additional, Heerspink, H., additional, Abdul Sultan, A., additional, Lam, C., additional, Chen, T., additional, Nolan, S., additional, Pecoits-Filho, R., additional, and Pollock, C., additional

Published
2021
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23. POS-328 THE BURDEN OF HYPERKALEMIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A REPORT FROM THE DISCOVER CKD RETROSPECTIVE COHORT

Author

JAMES, G., primary, Carrero, J.J., additional, Kumar, S., additional, Fishbane, S., additional, Wittbrodt, E., additional, Kanda, E., additional, Hedman, K., additional, Kashihara, N., additional, Kosiborod, M., additional, Lainscak, M., additional, Lam, C., additional, Pollock, C., additional, Stenvinkel, P., additional, Wheeler, D.C., additional, and Pecoits-Filho, R., additional

Published
2021
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24. POS-526 UNDERSTANDING THE PATIENT EXPERIENCE AND CLINICAL COURSE DURING THE INCIDENT DIALYSIS PERIOD: DESIGN AND IMPLEMENTATION OF A DOPPS CHINA STUDY

Author

HENN, L., primary, Ni, Z., additional, Liang, X., additional, Guedes, M., additional, Zhao, J., additional, Wittbrodt, E., additional, Khan, F., additional, Sloand, J., additional, Garcia-Sanchez, J.J., additional, Hedman, K., additional, James, G., additional, Pecoits-Filho, R., additional, Pisoni, R., additional, Robinson, B., additional, and Zuo, L., additional

Published
2021
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25. POS-319 EMERGENCY AND CRITICAL HEALTHCARE RESOURCE UTILISATION OF PATIENTS WITH CHRONIC KIDNEY DISEASE ACCORDING TO SEVERITY OF ALBUMINURIA: A REPORT FROM THE DISCOVER CKD RETROSPECTIVE COHORT

Author

GARCIA SANCHEZ, J.J., primary, Carrero, J.J., additional, Arnold, M., additional, Heerspink, H., additional, James, G., additional, Lam, C., additional, Abdul Sultan, A., additional, Pollock, C., additional, Chen, T., additional, Nolan, S., additional, and Pecoits-Filho, R., additional

Published
2021
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26. POS-329 TREATMENT PATTERNS IN CHRONIC KIDNEY DISEASE PATIENTS WITH HYPERKALEMIA: A REPORT FROM THE DISCOVER CKD RETROSPECTIVE COHORT

Author

JAMES, G., primary, Carrero, J.J., additional, Kumar, S., additional, Fishbane, S., additional, Wittbrodt, E., additional, Kanda, E., additional, Hedman, K., additional, Kashihara, N., additional, Kosiborod, M., additional, Lainscak, M., additional, Lam, C., additional, Pollock, C., additional, Stenvinkel, P., additional, Wheeler, D.C., additional, and Pecoits-Filho, R., additional

Published
2021
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27. POS-832 DAPAGLIFLOZIN IN IgA NEPHROPATHY: FINDINGS FROM THE DAPA-CKD TRIAL

Author

Lambers Heerspink, H., primary, Toto, R.D., additional, Jongs, N., additional, Vart, P., additional, Chertow, G.M., additional, Hou, F.F., additional, McMurray, J.J.V., additional, Pecoits-Filho, R., additional, Correa-Rotter, R., additional, Rossing, P., additional, Sjöström, C.D., additional, Stefánsson, B.V., additional, Umanath, K., additional, Langkilde, A.M., additional, and Wheeler, D.C., additional

Published
2021
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28. POS-503 EVALUATING CHRONIC KIDNEY DISEASE PROGRESSION: A REPORT FROM THE DISCOVER CKD RETROSPECTIVE COHORT

Author

ABDUL SULTAN, A., primary, Heerspink, H., additional, Arnold, M., additional, Pollock, C., additional, Garcia Sanchez, J.J., additional, Carrero, J.J., additional, Pecoits-Filho, R., additional, Lam, C., additional, Kashihara, N., additional, Kanda, E., additional, Kosiborod, M., additional, Fishbane, S., additional, Lainscak, M., additional, Stenvinkel, P., additional, and Wheeler, D.C., additional

Published
2021
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31. Risk factors for incident kidney disease in older adults: an Australian prospective population-based study

Author

Kang, A, Sukkar, L, Hockham, C, Jun, M, Young, T, Scaria, A, Foote, C, Neuen, BL, Cass, A, Pollock, C, Comino, E, Lung, T, Pecoits-Filho, R, Rogers, K, Jardine, MJ, and EXTEND45 Study Steering Committee†

Subjects
Male, 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1117 Public Health and Health Services, Incidence, Australia, Cohort Studies, Risk Factors, General & Internal Medicine, Humans, Female, Obesity, Prospective Studies, Renal Insufficiency, Chronic, Aged, Glomerular Filtration Rate
Abstract

BACKGROUND AND AIM: To determine risk factors for incident chronic kidney disease (CKD) in a large population-based cohort. METHODS: This prospective opt-in population-based cohort study is based on the 45 and Up Study, where New South Wales residents aged ≥45 years were randomly sampled from the Services Australia database and agreed to complete the 45 and Up Study baseline questionnaire and have their responses linked to their health data in routinely collected databases. The primary outcome was the development of incident CKD, defined as eGFR

Published
2020

32. Incidence and associations of chronic kidney disease in community participants with diabetes: A 5-year prospective analysis of the EXTEND45 study

Author

Sukkar, L, Kang, A, Hockham, C, Young, T, Jun, M, Foote, C, Pecoits-Filho, R, Neuen, B, Rogers, K, Pollock, C, Cass, A, Sullivan, D, Wong, G, Knight, J, Peiris, D, Gallagher, M, Jardine, M, Sukkar, L, Kang, A, Hockham, C, Young, T, Jun, M, Foote, C, Pecoits-Filho, R, Neuen, B, Rogers, K, Pollock, C, Cass, A, Sullivan, D, Wong, G, Knight, J, Peiris, D, Gallagher, M, and Jardine, M

Abstract

OBJECTIVE To determine the incidence of and factors associated with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 in people with diabetes. RESEARCH DESIGN AND METHODS Weidentified people with diabetes in the EXamining ouTcomEs in chroNic Disease in the 45 andUp Study (EXTEND45), a population-based cohort study (2006-2014) that linked the Sax Institute's 45 and Up Study cohort to community laboratory and administrative data in New South Wales, Australia. The study outcome was the first eGFR measurement <60 mL/min/1.73 m2 recorded during the follow-up period. Participants with eGFR < 60 mL/min/1.73 m2 at baseline were excluded. We used Poisson regression to estimate the incidence of eGFR <60 mL/min/1.73 m2 and multivariable Cox regression to examine factors associated with the study outcome. RESULTS Of 9,313 participants with diabetes, 2,106 (22.6%) developed incident eGFR <60 mL/min/1.73 m2 over a median follow-up time of 5.7 years (interquartile range, 3.0- 5.9 years). The eGFR <60 mL/min/1.73m2 incidence rate per 100 person-years was 6.0 (95% CI 5.7-6.3) overall, 1.5 (1.3-1.9) in participants aged 45-54 years, 3.7 (3.4- 4.0) for 55-64 year olds, 7.6 (7.1-8.1) for 65-74 year olds, 15.0 (13.0-16.0) for 75-84 year olds, and 26.0 (22.0-32.0) for those aged 85 years and over. In a fully adjusted multivariable model incidence was independently associated with age (hazard ratio 1.23 per 5-year increase; 95% CI 1.19-1.26), geography (outer regional and remote versus major city: 1.36; 1.17-1.58), obesity (obese class III versus normal: 1.44; 1.16-1.80), and the presence of hypertension (1.52; 1.33-1.73), coronary heart disease (1.13; 1.02-1.24), cancer (1.30; 1.14-1.50), and depression/anxiety (1.14; 1.01-1.27). CONCLUSIONS In participants with diabetes, the incidence of an eGFR <60 mL/min/1.73 m2 was high. Older age, remoteness of residence, and the presence of various comorbid conditions were associated with higher incidence.

Published
2020

33. Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Author

Wilkie M., Madero M., Sarafidis P.A., Unruh M.L., Wang A.Y.-M., Weiner D.E., Cheung M., Jadoul M., Winkelmayer W.C., Adragao T., Anumudu S.J., Chan C.T., Cheung A.K., Costanzo M.R., Dasgupta I., Davenport A., Davies S.J., Dekker M.J.E., Dember L.M., Gallego D., Gomez R., Hawley C.M., Hecking M., Iseki K., Jha V., Kooman J.P., Kovesdy C.P., Lacson E., Liew A., Lok C.E., McIntyre C.W., Mehrotra R., Miskulin D.C., Movilli E., Paglialonga F., Pecoits-Filho R., Perl J., Pollock C.A., Riella M.C., Rossignol P., Shroff R., Sola L., Sondergaard H., Tang S.C.W., Tong A., Tsukamoto Y., Watnick S., Weir M.R., Wetmore J.B., Wilkie C., Lindley E., Polkinghorne K.R., Flythe J.E., Chang T.I., Gallagher M.P., Wilkie M., Madero M., Sarafidis P.A., Unruh M.L., Wang A.Y.-M., Weiner D.E., Cheung M., Jadoul M., Winkelmayer W.C., Adragao T., Anumudu S.J., Chan C.T., Cheung A.K., Costanzo M.R., Dasgupta I., Davenport A., Davies S.J., Dekker M.J.E., Dember L.M., Gallego D., Gomez R., Hawley C.M., Hecking M., Iseki K., Jha V., Kooman J.P., Kovesdy C.P., Lacson E., Liew A., Lok C.E., McIntyre C.W., Mehrotra R., Miskulin D.C., Movilli E., Paglialonga F., Pecoits-Filho R., Perl J., Pollock C.A., Riella M.C., Rossignol P., Shroff R., Sola L., Sondergaard H., Tang S.C.W., Tong A., Tsukamoto Y., Watnick S., Weir M.R., Wetmore J.B., Wilkie C., Lindley E., Polkinghorne K.R., Flythe J.E., Chang T.I., and Gallagher M.P.

Abstract

Blood pressure (BP) and volume control are critical components of dialysis care and have substantial impacts on patient symptoms, quality of life, and cardiovascular complications. Yet, developing consensus best practices for BP and volume control have been challenging, given the absence of objective measures of extracellular volume status and the lack of high-quality evidence for many therapeutic interventions. In February of 2019, Kidney Disease: Improving Global Outcomes (KDIGO) held a Controversies Conference titled Blood Pressure and Volume Management in Dialysis to assess the current state of knowledge related to BP and volume management and identify opportunities to improve clinical and patient-reported outcomes among individuals receiving maintenance dialysis. Four major topics were addressed: BP measurement, BP targets, and pharmacologic management of suboptimal BP; dialysis prescriptions as they relate to BP and volume; extracellular volume assessment and management with a focus on technology-based solutions; and volume-related patient symptoms and experiences. The overarching theme resulting from presentations and discussions was that managing BP and volume in dialysis involves weighing multiple clinical factors and risk considerations as well as patient lifestyle and preferences, all within a narrow therapeutic window for avoiding acute or chronic volume-related complications. Striking this challenging balance requires individualizing the dialysis prescription by incorporating comorbid health conditions, treatment hemodynamic patterns, clinical judgment, and patient preferences into decision-making, all within local resource constraints.Copyright © 2020 International Society of Nephrology

Published
2020

34. Identifying critically important vascular access outcomes for trials in haemodialysis: An international survey with patients, caregivers and health professionals.

Author

Irish A.B., Mori T.A., Polkinghorne K.R., Hawley C.M., Viecelli A.K., Howell M., Tong A., Teixeira-Pinto A., O'Lone E., Ju A., Craig J.C., Hooi L.-S., Lee T., Lok C.E., Quinn R.R., Vachharajani T.J., Vanholder R., Zuo L., Tordoir J., Pecoits-Filho R., Yuo T., Kopperschmidt P., Johnson D.W., Pascoe E.M., Smith R., Irish A.B., Mori T.A., Polkinghorne K.R., Hawley C.M., Viecelli A.K., Howell M., Tong A., Teixeira-Pinto A., O'Lone E., Ju A., Craig J.C., Hooi L.-S., Lee T., Lok C.E., Quinn R.R., Vachharajani T.J., Vanholder R., Zuo L., Tordoir J., Pecoits-Filho R., Yuo T., Kopperschmidt P., Johnson D.W., Pascoe E.M., and Smith R.

Abstract

Background: Vascular access outcomes reported across haemodialysis (HD) trials are numerous, heterogeneous and not always relevant to patients and clinicians. This study aimed to identify critically important vascular access outcomes. Method(s): Outcomes derived from a systematic review, multi-disciplinary expert panel and patient input were included in a multilanguage online survey. Participants rated the absolute importance of outcomes using a 9-point Likert scale (7-9 being critically important). The relative importance was determined by a best-worst scale using multinomial logistic regression. Open text responses were analysed thematically. Result(s): The survey was completed by 873 participants [224 (26%) patients/caregivers and 649 (74%) health professionals] from 58 countries. Vascular access function was considered the most important outcome (mean score 7.8 for patients and caregivers/8.5 for health professionals, with 85%/95% rating it critically important, and top ranked on best-worst scale), followed by infection (mean 7.4/8.2, 79%/92% rating it critically important, second rank on best-worst scale). Health professionals rated all outcomes of equal or higher importance than patients/caregivers, except for aneurysms. We identified six themes: necessity for HD, applicability across vascular access types, frequency and severity of debilitation, minimizing the risk of hospitalization and death, optimizing technical competence and adherence to best practice and direct impact on appearance and lifestyle. Conclusion(s): Vascular access function was the most critically important outcome among patients/caregivers and health professionals. Consistent reporting of this outcome across trials in HD will strengthen their value in supporting vascular access practice and shared decision making in patients requiring HD.Copyright © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

Published
2020

35. SUN-095 INTERNATIONAL VARIATION IN CLINIC HEMOGLOBIN TARGETS AND ACHIEVED HEMOGLOBIN LEVELS IN ADVANCED CKD: RESULTS FROM THE CKD OUTCOMES AND PRACTICE PATTERNS STUDY (CKDOPPS)

Author

Lopes, M., primary, Tu, C., additional, Zee, J., additional, Allum, A., additional, van Haalen, H., additional, Sloand, J., additional, Glen, J., additional, Reichel, H., additional, Stengel, B., additional, Sukul, N., additional, Wong, M., additional, Lopes, A.A., additional, Pisoni, R., additional, Robinson, B., additional, and Pecoits-Filho, R., additional

Published
2020
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40. Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference

Author

Cheung, A.K., Chang, T.I., Cushman, W.C., Furth, S.L., Ix, J.H., Pecoits-Filho, R., Perkovic, V., Sarnak, M.J., Tobe, S.W., Tomson, C.R.V., Cheung, M., Wheeler, D.C., Winkelmayer, W.C., and Mann, J.F.E.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

In September 2017, KDIGO (Kidney Disease: Improving Global Outcomes) convened a Controversies Conference titled Blood Pressure in Chronic Kidney Disease (CKD). The purpose of the meeting was to consider which recommendations from the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKD should be reevaluated based on new evidence from clinical trials. Participants included a multidisciplinary panel of clinical and scientific experts. Discussions focused on the optimal means for measuring blood pressure (BP) as well as managing BP in CKD patients. Consistent with the 2012 Guideline, the conference did not address BP management in patients on maintenance dialysis.

Published
2019

41. Chronic Kidney Disease and Coronary Artery Disease: JACC State-of-the-Art Review

Author

Sarnak, M. J., Amann, K., Bangalore, S., Cavalcante, J. L., Charytan, D. M., Craig, J. C., Gill, J. S., Hlatky, M. A., Jardine, A. G., Landmesser, U., Newby, L. K., Herzog, C. A., Cheung, M., Wheeler, D. C., Winkelmayer, W. C., Marwick, T. H., Banerjee, D., Briguori, C., Chang, T. I., Chen, C. -L., Defilippi, C. R., Ding, X., Ferro, C. J., Gill, J., Gossl, M., Isbel, N. M., Ishii, H., Jardine, M. J., Kalra, P. A., Laufer, G., Lentine, K. L., Lobdell, K., Lok, C. E., London, G. M., Malyszko, J., Mark, P. B., Marwan, M., Nie, Y., Parfrey, P. S., Pecoits-Filho, R., Pilmore, H., Qunibi, W. Y., Raggi, P., Rattazzi, M., Rossignol, P., Ruturi, J., Sabanayagam, C., Shanahan, C. M., Shroff, G. R., Shroff, R., Webster, A. C., Weiner, D. E., Winther, S., Wiseman, A. C., Yip, A., and Zarbock, A.

Subjects
calcification, acute coronary syndromes, chronic kidney disease, coronary artery disease, revascularization
Published
2019

44. Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups Results From the Randomized CREDENCE Trial

Author

Mahaffey, KW, Jardine, MJ, Bompoint, S, Cannon, CP, Neal, B, Heerspink, HJL, Charytan, DM, Edwards, R, Agarwal, R, Bakris, G, Bull, S, Capuano, G, de Zeeuw, D, Greene, T, Levin, A, Pollock, C, Sun, T, Wheeler, DC, Yavin, Y, Zhang, H, Zinman, B, Rosenthal, N, Brenner, BM, Perkovic, V, Ahuad Guerrero, RA, Aizenberg, D, Pablo Albisu, J, Alvarisqueta, A, Bartolacci, I, Alberto Berli, M, Bordonava, A, Calella, P, Cecilia Cantero, M, Rodolfo Cartasegna, L, Cercos, E, Cecilia Coloma, G, Colombo, H, Commendatore, V, Cuadrado, J, Alberto Cuneo, C, Maria Cusumano, A, Guillermo Douthat, W, Dario Dran, R, Farias, E, Florencia Fernandez, M, Finkelstein, H, Fragale, G, Osvaldo Fretes, J, Horacio Garcia, N, Gastaldi, A, Gelersztein, E, Archibaldo Glenny, J, Pablo Gonzalez, J, Gonzalez Colaso, PDC, Goycoa, C, Cristian Greloni, G, Guinsburg, A, Hermida, S, Isaias Juncos, L, Isabel Klyver, M, Kraft, F, Krynski, F, Virginia Lanchiotti, P, Alfonso Leon de la Fuente, R, Marchetta, N, Mele, P, Nicolai, S, Antonio Novoa, P, Ines Orio, S, Otreras, F, Oviedo, A, Raffaele, P, Hector Resk, J, Rista, L, Rodriguez Papini, N, Sala, J, Santos, JC, Beatriz Schiavi, L, Sessa, H, Smith Casabella, T, Rosa Ulla, M, Valdez, M, Vallejos, A, Villarino, A, Esther Visco, V, Wassermann, A, Javier Zaidman, C, Cheung, NW, Droste, C, Fraser, I, Johnson, D, Mah, PM, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, RA, Alves da Costa, FA, Amodeo, C, Andreotti Turatti, LA, Bregman, R, Camelo Sanches, FC, Canani, LH, Chacra, AR, Cunha Borges, JL, Cunha Vencio, SA, da Silva Franco, RJ, d'Avila, D, Portes, EDS, de Souza, P, Deboni, LM, Fraige Filho, F, Geloneze Neto, B, Gomes, M, Kohara, SK, Keitel, E, Kerr Saraiva, JF, Kurtz Lisboa, HR, de Carvalho Contieri, FL, Milagres, R, Montenegro Junior, R, de Brito, CM, Hissa, MN, Nazario Sabbag, AR, Noronha, I, Panarotto, D, Pecoits Filho, R, Pereira, MA, Saporito, W, Scotton, AS, Schuch, T, de Almeida, RS, Ramos, CS, Felicio, JS, Thome, F, Tibes Hachmann, JC, Yamada, S, Hayashida, CY, Zanata Petry, TB, Zanella, MT, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A, Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Cherney, D, Chouinard, G, Conway, J, Cournoyer, S, DaRoza, G, De Serres, S, Dube, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, McMahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, N, Fernandez Montenegro, MA, Godoy Jorquera, JG, Medina Farina, M, Saavedra Gajardo, V, Vejar, M, Chen, N, Chen, Q, Gan, S, Kong, Y, Li, D, Li, W, Li, X, Lin, H, Liu, J, Lu, W, Mao, H, Ren, Y, Song, W, Sun, J, Sun, L, Tu, P, Wang, G, Yang, J, Yin, A, Yu, X, Zhao, M, Zheng, H, Accini Mendoza, JL, Arcos, E, Avendano, J, Diaz Ruiz, JEA, Garcia Ortiz, LH, Gonzalez, A, Hernandez Triana, E, Diego Higuera, J, Malaver, N, Ines Molina de Salazar, D, Rosero, R, Terront Lozano, MA, Valderrama Cometa, L, Valenzuela, A, Vargas Alonso, RD, Villegas, I, Yupanqui, H, Bartaskova, D, Barton, P, Belobradkova, J, Dohnalova, L, Drasnar, T, Ferkl, R, Halciakova, K, Klokocnikova, V, Kovar, R, Lastuvka, J, Lukac, M, Pesickova, S, Peterka, K, Pumprla, J, Rychlik, I, Saudek, F, Tesar, V, Valis, M, Weiner, P, Zemek, S, Alamartine, E, Borot, S, Cariou, B, Dussol, B, Fauvel, J-P, Gourdy, P, Klein, A, Le Meur, Y, Penfornis, A, Roussel, R, Saulnier, P-J, Thervet, E, Zaoui, P, Burst, V, Faghih, M, Faulmann, G, Haller, H, Jerwan-Keim, R, Maxeiner, S, Paschen, B, Plassmann, G, Rose, L, Gonzalez Orellana, RA, Paul Haase, F, Moreira Diaz, JP, Ramirez Roca, LA, Sanchez Arenales, JA, Sanchez Polo, JV, Turcios Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Abraham, O, Bhushan, RS, Deepak, D, Edwin, FM, Gopalakrishnan, N, Gracious, N, Hansraj, A, Jain, D, Keshavamurthy, CB, Khullar, D, Manisha, S, Peringat, J, Prasad, N, Satyanarayana, RK, Sreedhar, R, Sreelatha, M, Sudhakar, B, Vyasam, RC, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, De Nicola, L, Derosa, G, Di Carlo, A, Di Cianni, G, Frasca, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, FC, Serviddio, G, Stella, A, Trevisan, R, Veronelli, AM, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T, Kajiyama, S, Kashine, S, Kawada, T, Kodera, T, Kono, H, Koyama, K, Kumeda, Y, Miyauchi, S, Mizuyama, K, Niiya, T, Oishi, H, Ota, S, Sakakibara, T, Takai, M, Tomonaga, O, Tsujimoto, M, Wada, T, Wakasugi, M, Wakida, Y, Watanabe, T, Yamada, M, Yanagida, K, Yanase, T, Yumita, W, Gaupsiene, E, Kozloviene, D, Navickas, A, Urbanaviciene, E, Ghani, RA, Kadir, KA, Ali, N, Yusof, MDC, Gan, CL, Ismail, M, Kong, WY, Lam, SW, Lee, LY, Lim, SK, Loh, CL, Manocha, AB, Ng, KS, Ahmad, NNFN, Ratnasingam, V, Bin Shudim, SS, Vengadasalam, P, Abraira Munoz, LD, Alpizar Salazar, M, Baas Cruz, J, Burgos Soto, M, Chevaile Ramos, J, Chew Wong, A, Correa Rotter, JR, Diaz Escalante, T, Enriquez Sosa, FE, Flores Lozano, F, Flota Cervera, LF, Frenk Baron, P, Garcia Ballesteros, C, Gomez Rangel, JD, Herrera Jimenez, LE, Irizar Santana, SS, Jimenez Flores, F, Laviada Molina, H, Luna Ceballos, RI, del Campo Blanco, BM, Morales Franco, G, Moreno Loza, OT, Mustieles Rocha, C, Obrador Vera, G, Orozco Castellanos, R, Peralta Calcaneo, J, Reyes Rosano, MA, Rodriguez Pattzi, H, Rosas Guzman, J, Rucker Joerg, IE, Saavedra Sanchez, SB, Sanchez Mijangos, JH, Serrano Sanson, P, Tamayo y Orozco, JA, Tellez Chavez, E, Valdes Cepeda, A, Venegas Carrillo, L, Villagordoa Mesa, J, Zamarripa Escobedo, R, Baker, J, Noonan, P, Scott, R, Walker, R, Watson, E, Williams, M, Young, S, Abejuela, Z, Agra, J, Aquitania, G, Caringal, C, Comia, RS, Delos Santos, L, Gomez, O, Jimeno, C, Santos, F, Tan, G, Tolentino, M, Yao, C, Yap, YE, Ygpuara, MDL, Bijata-Bronisz, R, Hotlos, L, Januszewicz, A, Kaczmarek, B, Kaminska, A, Lazuka, L, Madej, A, Mazur, S, Mlodawska-Choluj, D, Nowicki, M, Orlowska-Kowalik, G, Popenda, G, Rewerska, B, Sowinski, D, Angelescu, LM, Anghel, V, Avram, R-I, Busegeanu, M-M, Cif, A, Cosma, D, Crisan, C, Demian, LD, Ferariu, IE, Halmagyi, I, Hancu, N, Munteanu, M, Negru, D, Onaca, AG, Petrica, L, Popa, AR, Ranetti, A-E, Serafinceanu, C, Toarba, C, Agafyina, A, Barbarash, O, Barysheva, O, Chizhov, D, Dobronravov, V, Dreval, A, Glinkina, I, Grineva, E, Khirmanov, V, Kolmakova, E, Koroleva, T, Kvitkova, L, Marasaev, V, Mkrtumyan, A, Morugova, T, Nagibovich, G, Nagibovich, O, Nedogoda, S, Osipova, I, Raskina, T, Samoylova, Y, Sazonova, O, Shamkhalova, M, Shutemova, E, Shwartz, Y, Uriasyev, O, Vorobyev, S, Zateyshchikova, A, 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Pharr, W, Phillips, A, Purighalla, R, Quesada-Suarez, L, Ranjan, R, Rastogi, S, Rendell, M, Rich, L, Robinson, M, Rodriguez, H, Rosas, S, Saba, F, Sankaram, R, Sarin, R, Schreiman, R, Scott, D, Sekkarie, M, Sensenbrenner, J, Shakeel, M, Shanik, M, Shaw, S, Smith, S, Solomon, R, Sprague, A, Spry, L, Suchinda, P, Sultan, S, Surampudi, P, Sussman, S, Tan, A, Terrelonge, A, Thompson, M, Trespalacios, F, Trippe, B, Trueba, P, Twahirwa, M, Updegrove, J, Van Buren, P, Vannorsdall, M, Varghese, F, Velasquez-Mieyer, P, Ventrapragada, S, Vukotic, G, Wadud, K, Warren, M, Watson, H, Watts, R, Weiner, D, Welker, J, Welsh, J, Williams, S, and Zaniewski-Singh, M

Abstract

BACKGROUND: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). METHODS: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. RESULTS: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67-0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49-0.94]) and secondary (HR, 0.85 [95% CI, 0.69-1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61-1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59-1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56-1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). CONCLUSIONS: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02065791.

Published
2019

45. Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease

Author

Pinho, N. Alencar de, Levin, A., Fukagawa, M., Hoy, W.E., Pecoits-Filho, R., Reichel, H., Robinson, B., Kitiyakara, C., Wang, Jinwei, Eckardt, K.U., Jha, V., Oh, K.H., Sola, L., Eder, S., Borst, M. de, Brand, J. van den, Taal, M., Feldman, H.I., Stengel, B., Pinho, N. Alencar de, Levin, A., Fukagawa, M., Hoy, W.E., Pecoits-Filho, R., Reichel, H., Robinson, B., Kitiyakara, C., Wang, Jinwei, Eckardt, K.U., Jha, V., Oh, K.H., Sola, L., Eder, S., Borst, M. de, Brand, J. van den, Taal, M., Feldman, H.I., and Stengel, B.

Abstract

Contains fulltext : 215593.pdf (publisher's version ) (Closed access), Although blood pressure control is a major goal in chronic kidney disease, no worldwide overview of either its achievement or antihypertensive prescriptions is currently available. To evaluate this we compared crude prevalence of uncontrolled blood pressure among 17 cohort studies, including 34 602 individuals with estimated glomerular filtration rate under 60 ml/min/1.73 m(2) and treated hypertension across four continents, and estimated observed to expected prevalence ratios, adjusted for potential confounders. Crude prevalence of blood pressure of 140/90 mm Hg or more varied from 28% to 61% and of blood pressure of 130/80 or more from 54% to 84%. Adjusted prevalence ratios indicated poorer hypertension control than expected in cohorts from European countries, India, and Uruguay, and better control in patients from North American and high-income Asian countries. Four antihypertensive drug classes or more were prescribed to more than 30% of participants in North American and some European cohorts, but this practice was less common elsewhere. Renin angiotensin-aldosterone system inhibitors were the most common antihypertensive drugs, prescribed for 54% to 91% of cohort participants. Differences for other drug classes were much stronger, ranging from 11% to 79% for diuretics, 22% to 70% for beta-blockers, and 27% to 75% for calcium-channel blockers. The confounders studied explain only a part of the international variation in blood pressure control among individuals with chronic kidney disease. Thus, considerable heterogeneity in prescription patterns worldwide calls for further investigation into the impact of different approaches on patient outcomes.

Published
2019

50. KIDNEY FUNCTION, GLUCOSE-LOWERING TREATMENT AND HBA1C LEVELS IN PEOPLE WITH PREVALENT DIABETES: A POPULATION-BASED COHORT STUDY (EXTEND45)

Author

Foote, C, Jun, M, Sukkar, L, Kang, A, Rogers, K, Baker, J, Scaria, A, Pecoits-Filho, R, Cass, A, Sullivan, D, Gallagher, M, Pollock, C, Wong, G, Knight, J, Peiris, D, Jardine, M, Foote, C, Jun, M, Sukkar, L, Kang, A, Rogers, K, Baker, J, Scaria, A, Pecoits-Filho, R, Cass, A, Sullivan, D, Gallagher, M, Pollock, C, Wong, G, Knight, J, Peiris, D, and Jardine, M

Published
2018

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