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2. Whole Exome Sequencing Identifies Epithelial and Immune Dysfunction‐Related Biomarkers in Food Protein‐Induced Enterocolitis Syndrome.

Author

Camino‐Mera, Alba, Pardo‐Seco, Jacobo, Bello, Xabier, Argiz, Laura, Boyle, Robert J., Custovic, Adnan, Herberg, Jethro, Kaforou, Myrsini, Arasi, Stefania, Fiocchi, Alessandro, Pecora, Valentina, Barni, Simona, Mori, Francesca, Bracamonte, Teresa, Echeverria, Luis, O'Valle‐Aísa, Virginia, Hernández‐Martínez, Noelia Lara, Carballeira, Iria, García, Emilio, and Garcia‐Magan, Carlos

Subjects
INFLAMMATORY bowel diseases, DELAYED diagnosis, FOOD allergy, GENETIC variation, GENETICS, MILK allergy
Abstract

Background: Food protein‐induced enterocolitis syndrome (FPIES) is a food allergy primarily affecting infants, often leading to vomiting and shock. Due to its poorly understood pathophysiology and lack of specific biomarkers, diagnosis is frequently delayed. Understanding FPIES genetics can shed light on disease susceptibility and pathophysiology—key to developing diagnostic, prognostic, preventive and therapeutic strategies. Using a well‐characterised cohort of patients we explored the potential genome‐wide susceptibility factors underlying FPIES. Methods: Blood samples from 41 patients with oral food challenge‐proven FPIES were collected for a comprehensive whole exome sequencing association study. Results: Notable genetic variants, including rs872786 (RBM8A), rs2241880 (ATG16L1) and rs2289477 (ATG16L1), were identified as significant findings in FPIES. A weighted SKAT model identified six other associated genes including DGKZ and SIRPA. DGKZ induces TGF‐β signalling, crucial for epithelial barrier integrity and IgA production; RBM8A is associated with thrombocytopenia absent radius syndrome, frequently associated with cow's milk allergy; SIRPA is associated with increased neutrophils/monocytes in inflamed tissues as often observed in FPIES; ATG16L1 is associated with inflammatory bowel disease. Coexpression correlation analysis revealed a functional correlation between RBM8A and filaggrin gene (FLG) in stomach and intestine tissue, with filaggrin being a known key pathogenic and risk factor for IgE‐mediated food allergy. A transcriptome‐wide association study suggested genetic variability in patients impacted gene expression of RBM8A (stomach and pancreas) and ATG16L1 (transverse colon). Conclusions: This study represents the first case–control exome association study of FPIES patients and marks a crucial step towards unravelling genetic susceptibility factors underpinning the syndrome. Our findings highlight potential factors and pathways contributing to FPIES, including epithelial barrier dysfunction and immune dysregulation. While these results are novel, they are preliminary and need further validation in a second cohort of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Reactivity to allergenic food contaminants: A study on products on the market

Author

Fiocchi, Alessandro, primary, Monaci, Linda, additional, De Angelis, Elisabetta, additional, Calandrelli, Veronica, additional, Dahdah, Lamia, additional, Valluzzi, Rocco, additional, Urbani, Sara, additional, Mazzuca, Carmen, additional, Arasi, Stefania, additional, Cafarotti, Arianna, additional, Riccardi, Carla, additional, Artesani, Maria Cristina, additional, Putignani, Lorenza, additional, Pecora, Valentina, additional, Marzano, Valeria, additional, and Fierro, Vincenzo, additional

Published
2023
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7. Botanical Impurities in the Supply Chain: A New Allergenic Risk Exacerbated by Geopolitical Challenges.

Author

Dinardo, Giulio, Dahdah, Lamia, Cafarotti, Arianna, Arasi, Stefania, Fierro, Vincenzo, Pecora, Valentina, Mazzuca, Carmen, Urbani, Sara, Artesani, Maria Cristina, Riccardi, Carla, Valluzzi, Rocco Luigi, Indolfi, Cristiana, Miraglia del Giudice, Michele, and Fiocchi, Alessandro

Abstract

Background: The supply chains of food raw materials have recently been heavily influenced by geopolitical events. Products that came from, or transited through, areas currently in conflict are now preferentially supplied from alternative areas. These changes may entail risks for food safety. Methods: We review the potential allergenicity of botanical impurities, specifically vegetable contaminants, with particular attention to the contamination of vegetable oils. We delve into the diverse types of botanical impurities, their sources, and the associated allergenic potential. Our analysis encompasses an evaluation of the regulatory framework governing botanical impurities in food labeling. Results: Unintended plant-derived contaminants may manifest in raw materials during various stages of food production, processing, or storage, posing a risk of allergic reactions for individuals with established food allergies. Issues may arise from natural occurrence, cross-contamination in the supply chain, and contamination at during production. The food and food service industries are responsible for providing and preparing foods that are safe for people with food allergies: we address the challenges inherent in risk assessment of botanical impurities. Conclusions: The presence of botanical impurities emerges as a significant risk factor for food allergies in the 2020s. We advocate for regulatory authorities to fortify labeling requirements and develop robust risk assessment tools. These measures are necessary to enhance consumer awareness regarding the potential risks posed by these contaminants. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Featured Cover.

Author

Camino‐Mera, Alba, Pardo‐Seco, Jacobo, Bello, Xabier, Argiz, Laura, Boyle, Robert J., Custovic, Adnan, Herberg, Jethro, Kaforou, Myrsini, Arasi, Stefania, Fiocchi, Alessandro, Pecora, Valentina, Barni, Simona, Mori, Francesca, Bracamonte, Teresa, Echeverria, Luis, O'Valle‐Aísa, Virginia, Hernández‐Martínez, Noelia Lara, Carballeira, Iria, García, Emilio, and Garcia‐Magan, Carlos

Subjects
ENTEROCOLITIS, BIOMARKERS
Abstract

The article "Featured Cover" in Clinical & Experimental Allergy showcases research on biomarkers in Food Protein-Induced Enterocolitis Syndrome using Whole Exome Sequencing. The study was conducted by a team of researchers led by Alba Camino-Mera and includes a diverse group of contributors. The research sheds light on epithelial and immune dysfunction-related biomarkers in the syndrome. [Extracted from the article]

Published
2024
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19. Food allergy and food intolerance: diagnosis and treatment

Author

Patriarca, Giampiero, Schiavino, Domenico, Pecora, Valentina, Lombardo, Carla, Pollastrini, Emanuela, Aruanno, Arianna, Sabato, Vito, Colagiovanni, Amira, Rizzi, Angela, De Pasquale, Tiziana, Roncallo, Chiara, Decinti, Marzia, Musumeci, Sonia, Gasbarrini, Giovanni, Buonomo, Alessandro, and Nucera, Eleonora

Published
2009
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25. Oral Rush Desensitization in Peanut Allergy: A Case Report

Author

Patriarca, Giampiero, Nucera, Eleonora, Pollastrini, Emanuela, De Pasquale, Tiziana, Lombardo, Carla, Buonomo, Alessandro, Roncallo, Chiara, Pecora, Valentina, Musumeci, Sonia, Altomonte, Giorgia, Alonzi, Cristiana, Schiavino, Domenico, and Gasbarrini, Giovanni

Published
2006
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27. Specific oral immunotherapy in food allergic patients: transient or persistent tolerance?

Author

Nucera, Eleonora, Ricci, Anna Giulia, Rizzi, Angela, Mezzacappa, Simona, Di Rienzo, Alessia, Pecora, Valentina, Patriarca, Giampiero, Buonomo, Alessandro, Aruanno, Arianna, Schiavino, Domenico, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Rizzi, Angela (ORCID:0000-0002-6795-746X), Schiavino, Domenico (ORCID:0000-0003-3824-0619), Nucera, Eleonora, Ricci, Anna Giulia, Rizzi, Angela, Mezzacappa, Simona, Di Rienzo, Alessia, Pecora, Valentina, Patriarca, Giampiero, Buonomo, Alessandro, Aruanno, Arianna, Schiavino, Domenico, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Rizzi, Angela (ORCID:0000-0002-6795-746X), and Schiavino, Domenico (ORCID:0000-0003-3824-0619)

Abstract

Introduction: The first therapeutic choice for food allergy is avoidance of the responsible food, but when this approach is not possible, specific oral desensitization could be considered as a good alternative. It is not clear yet whether the acquired tolerance is transient or persistent. Aim: We report on a subset of 13 patients of a larger study, treated successfully with specific oral tolerance induction who experienced secondary loss of tolerance after a period of allergen avoidance. Material and methods: Thirteen patients affected by IgE-mediated food allergy: to cow milk (3 patients), to hen egg (3 patients), to cod fish (2 patients), to peanuts (1 patient) and to corn (1 patient) confirmed by a complete allergological workup and a double-blind placebo-controlled food challenge (DBPCFC), were treated with sublingual-oral desensitization. After the interruption of the maintenance phase, the laboratory tests were performed and 12 of 13 patients underwent DBPCFC. Results: Oral specific desensitization was completed successfully in all the 13 reported patients. At different times after the end of treatment, they decided, on their own initiative, to stop the ingestion of incriminated food. A new food allergen re-exposure caused adverse reactions in 12 of 13 patients. The detection of specific IgE and IgG4 during the period of allergen avoidance showed an increase in or a stable level of specific IgE and a decrease in specific IgG4 in 8 patients. Conclusions: According to our experience, the tolerance obtained through the desensitizing treatment is transient and so the regular allergen intake is necessary for its maintenance.

Published
2018

28. Proceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects: Rome, Italy/Vatican City. 27-29 April 2017

Author

Traina, Giovanni, Valluzzi, Rocco Luigi, Fierro, Vincenzo, Riccardi, Carla, Artesani, Maria Cristina, De Vuono, Andrea, Fiocchi, Alessandro, Martelli, Alberto G, Ríos, Luis Alberto, Alcocer, Christian R, Navarrete, Elsy, Del Rio Navarro, Blanca Estela, Gonzalez, Victor, Velasco, Berenice, Perez Aviles, Herberth J, Fernandez, Roberto Jose, Pozo, F Cesar, Farhan, Abdal Jabbar, Arshad, Hasan, Hussain, Ahmed, Sharikadze, Olena, Okhotnikova, Olena, Alcover, Javier, Rodriguez, Diego, Pineda, Fernando, Dalal, Ilan, Weinbrand-Goichberg, Jenny, Benor, Shira, Rottem, Menachem, Kivity, Shmuel, Sato, Sakura, Yanagida, Noriyuki, Ebisawa, Motohiro, Umanets, Tetiana, Antipkin, Youriy, Barzylovich, Vladyslava, Lapshyn, Volodymyr, Umanets, Mykola, Yuriev, Sergey, Bekir, Suzan, Pincock, Tobias, Vieira Hernandez, Alberto, Capriles Hulett, Arnaldo, Sánchez Borges, Mario, Fabiano, Fabiola, Albarran, Carlos, Goyal, Rohit, Gupta, Shilpa, Gaurav, Garg, Luskin, Allan T, Griffin, Noelle M, Wagelie-Steffen, Amy, Trzaskoma, Benjamin L, Limb, Susan L, Busse, William W, Zeiger, Robert S, Gonzalez-Reyes, Erika, Casale, Thomas B, Chipps, Bradley E, Sugizaki, Chizuko, Goto, Fumiko, Yamaide, Akiko, Mitsunaga, Kanako, Tomiita, Minako, Hoshioka, Akira, Shimojo, Naoki, Pop, Liviu L, Ciucǎ, Ioana-Mihaela, Tǎmaş, Liviu, Lazarescu, Marilena, Pienar, Corina, Yamaide, Fumiya, Fikri, Bahrul, Sato, Hironori, Okishima, Naoko, Kobayashi, Miyabi, Takai, Mizuki, Nishigata, Kotarou, Yoda, Ryou, Oana, Yu-Ta, Kajiwara, Chifu, Shimodaira, Moe, Suzuki, Tomoka, Iizawa, Hiromi, Kamijo, Koji, Karmakar, Bijoya, Bhattacharya, Swati Gupta, Blohlávková, Simona, Kopelentová, Eliška, Víšek, Petr, Štádler, Jakub, Šetinová, Ivana, Novobílská, Jana, Lundelin, Krisa, Salminen, Seppo, Isolauri, Erika, Pitt, Tracy, Flanders, Tamar, Peñalver, Marcos, Martínez, Patricia, Lluch, Magdalena, Malet, Alfonso, Nam, Young-Hee, Jin, Hyun Jung, Lee, Soo-Keol, Kulalert, Prapasri, Sritipsukho, Paskorn, Pathumanond, Jayanton, Baynova, Krasimira, Labella, Marina, De Aramburu, Teresa, Prados, Manuel, Haanpää, Leena, Aarnio, Jasmin, Nermes, Merja, Af Ursin, Piia, Kaljonen, Anne, Bala, Nandana, Bhagwat, Ketaki, Hindley, James, Chapman, Martin, Baalasubramanian, Sivasankar, Besednjak-Kocijančič, Lilijana, SenGupta, Koyel, Antonova, Evgeniya, Kong, Amanda M, Iqbal, Ahmar, Teague, W Gerald, Trzaskoma, Benjamin, Ortiz, Benjamin, Paknis, Brandee, Iqbal, Amar, Rosen, Karin, Szefler, Stanley, Alblooshi, Afaf, Al-Hammadi, Suleiman, Vega, Arantza, Gutiérrez-Rivas, Raquel, Alonso, Ana Maria, Beitia, Juan Maria, Belén Mateo, Maria, Cárdenas, Remedios, García-Domínguez, Juan Jesús, Pitchon Dos Reis, Raquel, Gonçalves Alvim, Cristina, Andrade, Claudia, Reis, Adriana, Ribeiro, Henrique, Panaitescu Bunu, Carmen, Marusciac, Laura, Paralescu, Sorin, Tamas, Paul, Panitescu Bunu, Carmen, Martí Guadaño, Enrique, Escobar Bolaños, Carolina, Martí José, Natalia, Pau Casanovas, Pol, Biarnés Rib, Gemma, Castells, Mariana, de Vicente Jiménez, Talía, Mennini, Maurizio, De Angelis, Papola, Rea, Francesca, Malamisura, Monica, Tambucci, Renato, Dall'Oglio, Luigi, Del Chierico, Federica, Napolitano, Tania, Reddel, Silvia, Vernocchi, Pamela, D'Ambrosio, Angelo, Putignani, Lorenza, Dahdah, Lamia, Banzato, Claudia, Echeverría Zudaire, Luís Angel, Plaza, Ana María, Bosque García, Montserrat, Íbero, Marcel, Mazzina, Oscar, Marzano, Valeria, Pecora, Valeria, Koch, Pierluigi, Pecora, Valentina, Valentini, Diletta, Santamaria, Francesca, Valluzzi, Rocco, Mukherjee, Anwesha, Kandhare, Amit, and Bodhankar, Subhash

Published
2017

30. How to actively treat food allergy

Author

Pecora, Valentina, primary, Mennini, Maurizio, additional, Calandrelli, Veronica, additional, Patriarca, Giampiero, additional, Valluzzi, Rocco, additional, and Fierro, Vincenzo, additional

Published
2018
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36. lezioni di immunoallergologia

Author

PATRIARCA, GIAMPIERO, SCHIAVINO, DOMENICO, NUCERA, ELEONORA, PECORA, VALENTINA, SABATO, VITO, RIZZI, ANGELA, Nucera, Eleonora, Patriarca, Giampiero, Schiavino, Domenico, Colagiovanni, Amira, Pecora, Valentina, Sabato, Vito, Aruanno, Arianna, Buonomo, Alessandro, De Pasquale, Tiziana Maria Angela, Lombardo, Carla, Pascolini, Lucilla, Pollastrini, Emanuela, Rizzi, Angela, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Schiavino, Domenico (ORCID:0000-0003-3824-0619), De Pasquale, Tiziana Maria, Rizzi, Angela (ORCID:0000-0002-6795-746X), PATRIARCA, GIAMPIERO, SCHIAVINO, DOMENICO, NUCERA, ELEONORA, PECORA, VALENTINA, SABATO, VITO, RIZZI, ANGELA, Nucera, Eleonora, Patriarca, Giampiero, Schiavino, Domenico, Colagiovanni, Amira, Pecora, Valentina, Sabato, Vito, Aruanno, Arianna, Buonomo, Alessandro, De Pasquale, Tiziana Maria Angela, Lombardo, Carla, Pascolini, Lucilla, Pollastrini, Emanuela, Rizzi, Angela, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Schiavino, Domenico (ORCID:0000-0003-3824-0619), De Pasquale, Tiziana Maria, and Rizzi, Angela (ORCID:0000-0002-6795-746X)

Abstract

il sistema innunitario è un complesso di cellule e molecole specializzate nella distinzione del self e del non self.

Published
2010

37. Profilin desensitization: A case series

Author

Nucera, Eleonora, Aruanno, Arianna, Rizzi, Angela, Pecora, Valentina, Patriarca, Giampiero, Buonomo, Alessandro, Mezzacappa, Simona, Schiavino, Domenico, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Rizzi, Angela (ORCID:0000-0002-6795-746X), Schiavino, Domenico (ORCID:0000-0003-3824-0619), Nucera, Eleonora, Aruanno, Arianna, Rizzi, Angela, Pecora, Valentina, Patriarca, Giampiero, Buonomo, Alessandro, Mezzacappa, Simona, Schiavino, Domenico, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Rizzi, Angela (ORCID:0000-0002-6795-746X), and Schiavino, Domenico (ORCID:0000-0003-3824-0619)

Abstract

The role of profilin as an allergen has long been questioned. The capacity of profilin to induce respiratory symptoms has recently been demonstrated; moreover, over 50% of patients sensitized to profilin experienced symptoms after the ingestion of plant-derived foods, suggesting that profilin should be considered as a clinically relevant food allergen.We describe the cases of seven allergic patients with oral allergy syndrome and other adverse reactions after eating plant-derived food, that have been undergone to profilin desensitization treatment.The protocol started with a drop of profilin solution (50 µg/mL) diluted 1:1018 in water until the highest dose of 10 drops of undiluted solution three times a week. At the end of the treatment we observed a decreased mean diameter of profilin wheal in skin prick test (SPT) in five of the seven participants and in profilin specific IgE values in six patients that repeated the test. Regarding basophil activation test (BAT) and the detection of IgG4, we do not have significant results because the tests have to be repeated in some patients. Regarding the double-blind placebo-controlled challenges, after about 10 months of induction phase all the patients showed tolerance to several foods that they previously did not tolerate.Moreover, the immunotherapy with profilin has proved to be safe because no serious adverse events have been reported in our patients.In summary, the results of this exploratory study of sublingual immunotherapy (SLIT) for profilin allergy show that it can be a promising therapeutic option that could modify the clinical reactivity of the patients to the intake of plant-derived food.

Published
2016

38. Proceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects

Author

Traina, Giovanni, Valluzzi, Rocco Luigi, Fierro, Vincenzo, Riccardi, Carla, Artesani, Maria Cristina, De Vuono, Andrea, Fiocchi, Alessandro, Martelli, Alberto G., Ríos, Luis Alberto, Alcocer, Christian R., Navarrete, Elsy, Del Rio Navarro, Blanca Estela, Gonzalez, Victor, Velasco, Berenice, Perez Aviles, Herberth J., Fernandez, Roberto Jose, Pozo, F. Cesar, Farhan, Abdal Jabbar, Arshad, Hasan, Hussain, Ahmed, Sharikadze, Olena, Okhotnikova, Olena, Alcover, Javier, Rodriguez, Diego, Pineda, Fernando, Dalal, Ilan, Weinbrand-Goichberg, Jenny, Benor, Shira, Rottem, Menachem, Kivity, Shmuel, Sato, Sakura, Yanagida, Noriyuki, Ebisawa, Motohiro, Umanets, Tetiana, Antipkin, Youriy, Barzylovich, Vladyslava, Lapshyn, Volodymyr, Umanets, Mykola, Yuriev, Sergey, Bekir, Suzan, Pincock, Tobias, Vieira Hernandez, Alberto, Capriles Hulett, Arnaldo, Sánchez Borges, Mario, Fabiano, Fabiola, Albarran, Carlos, Goyal, Rohit, Gupta, Shilpa, Gaurav, Garg, Luskin, Allan T., Griffin, Noelle M., Wagelie-Steffen, Amy, Trzaskoma, Benjamin L., Limb, Susan L., Busse, William W., Zeiger, Robert S., Gonzalez-Reyes, Erika, Casale, Thomas, Chipps, Bradley E., Sugizaki, Chizuko, Goto, Fumiko, Yamaide, Akiko, Mitsunaga, Kanako, Tomiita, Minako, Hoshioka, Akira, Shimojo, Naoki, Pop, Liviu L., Ciucǎ, Ioana-Mihaela, Tǎmaş, Liviu, Lazarescu, Marilena, Pienar, Corina, Yamaide, Fumiya, Fikri, Bahrul, Sato, Hironori, Okishima, Naoko, Kobayashi, Miyabi, Takai, Mizuki, Nishigata, Kotarou, Yoda, Ryou, Oana, Yu-ta, Kajiwara, Chifu, Shimodaira, Moe, Suzuki, Tomoka, Iizawa, Hiromi, Kamijo, Koji, Karmakar, Bijoya, Bhattacharya, Swati Gupta, Blohlávková, Simona, Kopelentová, Eliška, Víšek, Petr, Štádler, Jakub, Šetinová, Ivana, Novobílská, Jana, Lundelin, Krisa, Salminen, Seppo, Isolauri, Erika, Pitt, Tracy, Flanders, Tamar, Peñalver, Marcos, Martínez, Patricia, Lluch, Magdalena, Malet, Alfonso, Nam, Young-Hee, Jin, Hyun Jung, Lee, Soo-Keol, Kulalert, Prapasri, Sritipsukho, Paskorn, Pathumanond, Jayanton, Baynova, Krasimira, Labella, Marina, De Aramburu, Teresa, Prados, Manuel, Haanpää, Leena, Aarnio, Jasmin, Nermes, Merja, af Ursin, Piia, Kaljonen, Anne, Bala, Nandana, Bhagwat, Ketaki, Hindley, James, Chapman, Martin, Baalasubramanian, Sivasankar, Besednjak-Kocijančič, Lilijana, SenGupta, Koyel, Antonova, Evgeniya, Kong, Amanda M., Iqbal, Ahmar, Teague, W. Gerald, Trzaskoma, Benjamin, Ortiz, Benjamin, Paknis, Brandee, Iqbal, Amar, Rosen, Karin, Szefler, Stanley, Alblooshi, Afaf, Al-Hammadi, Suleiman, Vega, Arantza, Gutiérrez-Rivas, Raquel, Alonso, Ana Maria, Beitia, Juan Maria, Belén Mateo, Maria, Cárdenas, Remedios, García-Domínguez, Juan Jesús, Pitchon dos Reis, Raquel, Gonçalves Alvim, Cristina, Andrade, Claudia, Reis, Adriana, Ribeiro, Henrique, Panaitescu Bunu, Carmen, Marusciac, Laura, Paralescu, Sorin, Tamas, Paul, Panitescu Bunu, Carmen, Martí Guadaño, Enrique, Escobar Bolaños, Carolina, Martí José, Natalia, Pau Casanovas, Pol, Biarnés Rib, Gemma, Castells, Mariana, de Vicente Jiménez, Talía, Mennini, Maurizio, De Angelis, Papola, Rea, Francesca, Malamisura, Monica, Tambucci, Renato, Dall'Oglio, Luigi, Del Chierico, Federica, Napolitano, Tania, Reddel, Silvia, Vernocchi, Pamela, D'Ambrosio, Angelo, Putignani, Lorenza, Dahdah, Lamia, Banzato, Claudia, Echeverría Zudaire, Luís Angel, Plaza, Ana María, Bosque, Montserrat, Íbero, Marcel, Mazzina, Oscar, Marzano, Valeria, Pecora, Valeria, Koch, Pierluigi, Pecora, Valentina, Valentini, Diletta, Santamaria, Francesca, Mukherjee, Anwesha, Kandhare, Amit, Bodhankar, Subhash, and Universitat Autònoma de Barcelona

Subjects
lcsh:Immunologic diseases. Allergy, Pulmonary and Respiratory Medicine, business.industry, Immunology, MEDLINE, Library science, Meeting Abstracts, Vatican City, Hot topics, Immunology and Allergy, Medicine, lcsh:RC581-607, business
Published
2017
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39. Profilin desensitization: A case series

Author

Nucera, Eleonora, primary, Aruanno, Arianna, additional, Rizzi, Angela, additional, Pecora, Valentina, additional, Patriarca, Giampiero, additional, Buonomo, Alessandro, additional, Mezzacappa, Simona, additional, and Schiavino, Domenico, additional

Published
2016
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42. Sensitization pattern to inhalant and food allergens in symptomatic children at first evaluation

Author

Fiocchi, Alessandro, Pecora, Valentina, Petersson, Carl Johan, Dahdah, Lamia, Borres, Magnus P., Amengual, Maria J., Huss-Marp, Johannes, Mazzina, Oscar, Di Girolamo, Francesco, Fiocchi, Alessandro, Pecora, Valentina, Petersson, Carl Johan, Dahdah, Lamia, Borres, Magnus P., Amengual, Maria J., Huss-Marp, Johannes, Mazzina, Oscar, and Di Girolamo, Francesco

Abstract

Background: Data on specific IgE sensitization prevalence in children with allergy-like symptoms seen in the primary care setting are rare. Early diagnosis of allergic diseases is important to prevent clinical manifestations, exacerbations or expansion of allergic diseases to other organ systems. The present study aims to assess the usefulness of early serological diagnosis in children with common allergic symptoms. Methods: 532 children (<15 years of age), with at least one of ten allergy-like symptoms, from 21 primary care centers in two geographic areas of Italy and Spain were included in the study. Patients were tested with, either Phadiatop (R) Infant (0-5 years of age) or Phadiatop (R) and food mix (fx5e) (>5 years of age) to discriminate atopic from non-atopic subjects. A blood sample of atopic subjects was taken for additional 6-26 specific IgE antibody determinations from a predefined panel using the ImmunoCAP (R) System. Results: 267 children (50.2 %) were positive in the initial test and were classified as atopic. 14 % were mono-sensitized, 37 % were sensitized to 2-3 allergens and 49 % to more than 3 allergens. The average number of symptoms in the atopic group was 3.3 vs 2.8 in the non-atopic group. The prevalence of sensitization to single allergens was highest for grass and ragweed pollen and house-dust mites (19-28 %). Sensitization to tree allergens was highest for olive tree (16.5 %). Cow's milk and egg white were the most sensitizing foods (similar to 15 %). Food allergen sensitization predominated in younger children (OR = 2.8) whereas the inverse occurred with inhalant allergens (OR = 2.5 to 5.6). A significant positive correlation between patient age and the number of sensitizations was found. Conclusions: Specific IgE sensitization in children with allergy-like symptoms is common. Multiple sensitization is predominating. Number of clinical symptoms was higher in the atopic group compared to the non-atopic without a correlation with the n

Published
2015
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43. Utility of Basophil Activation Test for monitoring the acquisition of clinical tolerance after oral desensitization to cow's milk: Pilot study

Author

Nucera, Eleonora, Pecora, Valentina, Buonomo, Alessandro, Rizzi, Angela, Aruanno, Arianna, Pascolini, Lucilla, Ricci, Anna Giulia, Di Rienzo, Alessia, Mezzacappa, Simona, Ferraironi, Manuela, Patriarca, Giampiero, Gasbarrini, Giovanni Battista, Schiavino, Domenico, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Rizzi, Angela (ORCID:0000-0002-6795-746X), Schiavino, Domenico (ORCID:0000-0003-3824-0619), Nucera, Eleonora, Pecora, Valentina, Buonomo, Alessandro, Rizzi, Angela, Aruanno, Arianna, Pascolini, Lucilla, Ricci, Anna Giulia, Di Rienzo, Alessia, Mezzacappa, Simona, Ferraironi, Manuela, Patriarca, Giampiero, Gasbarrini, Giovanni Battista, Schiavino, Domenico, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Rizzi, Angela (ORCID:0000-0002-6795-746X), and Schiavino, Domenico (ORCID:0000-0003-3824-0619)

Abstract

Objective: The quantification of basophil activation by flow cytometry is a useful tool for the assessment of immediate-type responses to food allergens and the prediction of clinical tolerance in food allergy patients. The aim of this study is to investigate how the analysis of allergen-induced CD63 up-regulation by flow cytometry can be effective in monitoring the acquisition of clinical tolerance by specific oral desensitization in food allergy. To our knowledge, this is the first study to examine this topic. Materials and methods: Three male patients affected by cow’s milk allergy underwent successful oral desensitization to cow’s milk. In order to monitor the acquired clinical tolerance that occurred after treatment, we performed laboratory tests for total and specific IgE, specific IgG4 and the Basophil Activation Test (BAT) both at baseline and at the end of the desensitization protocol. Results: Using a fluorescent enzyme immunoassay, the comparison of specific cow’s milk antibodies before and after treatment showed a decrease of specific IgE levels, without reaching normal values, and an increase of specific IgG4 levels. A complete suppression of cow’s milk proteins (a-lactoalbumin, b-lactoglobulin and casein) induced CD63 regulation was observed in all three reported cases. Conclusions: Using flow cytometry, food allergen-specific basophil responses could be monitored in order to identify an acquired tolerance induced by desensitization treatment. Although further studies are needed to develop this important new topic, it was interesting to note that the BAT seemed to be more sensitive and characterized by a close correlation with clinical tolerance.

Published
2015

44. Tolerability of aztreonam in patients with cell-mediated allergy to beta-lactams

Author

Buonomo, Alessandro, Nucera, Eleonora, De Pasquale, Tiziana Maria Angela, Pecora, Valentina, Lombardo, Carla, Sabato, Vito, Colagiovanni, Amira, Rizzi, Angela, Aruanno, Arianna, Pascolini, Lucilla, Patriarca, Giampiero, and Schiavino, Domenico

Subjects
Delayed-type hypersensitivity, Penicillin allergy, Adverse reactions to drugs, Settore MED/09 - MEDICINA INTERNA, Drug allergy
Published
2011

46. Utility of Basophil Activation Test for monitoring the acquisition of clinical tolerance after oral desensitization to cow's milk: Pilot study

Author

Nucera, Eleonora, primary, Pecora, Valentina, additional, Buonomo, Alessandro, additional, Rizzi, Angela, additional, Aruanno, Arianna, additional, Pascolini, Lucilla, additional, Ricci, Anna G, additional, Di Rienzo, Alessia, additional, Mezzacappa, Simona, additional, Ferraironi, Manuela, additional, Patriarca, Giampiero, additional, Gasbarrini, Giovanni, additional, and Schiavino, Domenico, additional

Published
2015
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47. Profilin desensitisation in patients with adverse reaction after plant‐derived: our experience

Author

Mezzacappa, Simona, primary, Nucera, Eleonora, additional, Pecora, Valentina, additional, Rizzi, Angela, additional, Aruanno, Arianna, additional, Pascolini, Lucilla, additional, Ferraironi, Manuela, additional, Ricci, Anna Giulia, additional, Di Rienzo, Alessia, additional, Centrone, Michele, additional, Buonomo, Alessandro, additional, and Schiavino, Domenico, additional

Published
2015
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49. lezioni di immunoallergologia

Author

Nucera, Eleonora, Patriarca, Giampiero, Schiavino, Domenico, Colagiovanni, Amira, Pecora, Valentina, Sabato, Vito, Aruanno, Arianna, Buonomo, Alessandro, De Pasquale, Tiziana Maria Angela, Lombardo, Carla, Pascolini, Lucilla, Pollastrini, Emanuela, and Rizzi, Angela

Subjects
Settore MED/09 - MEDICINA INTERNA, sistema immunitario
Published
2010

50. Allergie e intolleranze alimentari

Author

Nucera, Eleonora, Pecora, Valentina, Buonomo, Alessandro, De Pasquale, Tiziana Maria Angela, Sabato, Vito, Colagiovanni, Amira, Rizzi, Angela, Aruanno, Arianna, Pascolini, Lucilla, Ricci, Anna Giulia, and Schiavino, Domenico

Subjects
Allergia alimentare, Intolleranza alimentare, Settore MED/09 - MEDICINA INTERNA
Published
2010

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