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1. Searching for Heavy Dark Matter near the Planck Mass with XENON1T

Author

Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

Multiple viable theoretical models predict heavy dark matter particles with a mass close to the Planck mass, a range relatively unexplored by current experimental measurements. We use 219.4 days of data collected with the XENON1T experiment to conduct a blind search for signals from Multiply-Interacting Massive Particles (MIMPs). Their unique track signature allows a targeted analysis with only 0.05 expected background events from muons. Following unblinding, we observe no signal candidate events. This work places strong constraints on spin-independent interactions of dark matter particles with a mass between 1$\times$10$^{12}\,$GeV/c$^2$ and 2$\times$10$^{17}\,$GeV/c$^2$. In addition, we present the first exclusion limits on spin-dependent MIMP-neutron and MIMP-proton cross-sections for dark matter particles with masses close to the Planck scale., Comment: 7 pages, 6 figures

Published
2023
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2. Detector signal characterization with a Bayesian network in XENONnT

Author

XENON Collaboration, Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment
Abstract

We developed a detector signal characterization model based on a Bayesian network trained on the waveform attributes generated by a dual-phase xenon time projection chamber. By performing inference on the model, we produced a quantitative metric of signal characterization and demonstrate that this metric can be used to determine whether a detector signal is sourced from a scintillation or an ionization process. We describe the method and its performance on electronic-recoil (ER) data taken during the first science run of the XENONnT dark matter experiment. We demonstrate the first use of a Bayesian network in a waveform-based analysis of detector signals. This method resulted in a 3% increase in ER event-selection efficiency with a simultaneously effective rejection of events outside of the region of interest. The findings of this analysis are consistent with the previous analysis from XENONnT, namely a background-only fit of the ER data., Comment: 11 pages, 8 figures

Published
2023
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3. First Dark Matter Search with Nuclear Recoils from the XENONnT Experiment

Author

XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

We report on the first search for nuclear recoils from dark matter in the form of weakly interacting massive particles (WIMPs) with the XENONnT experiment which is based on a two-phase time projection chamber with a sensitive liquid xenon mass of $5.9$ t. During the approximately 1.1 tonne-year exposure used for this search, the intrinsic $^{85}$Kr and $^{222}$Rn concentrations in the liquid target were reduced to unprecedentedly low levels, giving an electronic recoil background rate of $(15.8\pm1.3)~\mathrm{events}/(\mathrm{t\cdot y \cdot keV})$ in the region of interest. A blind analysis of nuclear recoil events with energies between $3.3$ keV and $60.5$ keV finds no significant excess. This leads to a minimum upper limit on the spin-independent WIMP-nucleon cross section of $2.58\times 10^{-47}~\mathrm{cm}^2$ for a WIMP mass of $28~\mathrm{GeV}/c^2$ at $90\%$ confidence level. Limits for spin-dependent interactions are also provided. Both the limit and the sensitivity for the full range of WIMP masses analyzed here improve on previous results obtained with the XENON1T experiment for the same exposure., Comment: Limit points are included in the submission file

Published
2023
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4. The Triggerless Data Acquisition System of the XENONnT Experiment

Author

Aprile, E., Aalbers, J., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Coderre, D., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Rocchetti, A., Sanchez, L., Sanchez-Lucas, P., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., and Zhu, T.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The XENONnT detector uses the latest and largest liquid xenon-based time projection chamber (TPC) operated by the XENON Collaboration, aimed at detecting Weakly Interacting Massive Particles and conducting other rare event searches. The XENONnT data acquisition (DAQ) system constitutes an upgraded and expanded version of the XENON1T DAQ system. For its operation, it relies predominantly on commercially available hardware accompanied by open-source and custom-developed software. The three constituent subsystems of the XENONnT detector, the TPC (main detector), muon veto, and the newly introduced neutron veto, are integrated into a single DAQ, and can be operated both independently and as a unified system. In total, the DAQ digitizes the signals of 698 photomultiplier tubes (PMTs), of which 253 from the top PMT array of the TPC are digitized twice, at $\times10$ and $\times0.5$ gain. The DAQ for the most part is a triggerless system, reading out and storing every signal that exceeds the digitization thresholds. Custom-developed software is used to process the acquired data, making it available within $\mathcal{O}\left(10\text{ s}\right)$ for live data quality monitoring and online analyses. The entire system with all the three subsystems was successfully commissioned and has been operating continuously, comfortably withstanding readout rates that exceed $\sim500$ MB/s during calibration. Livetime during normal operation exceeds $99\%$ and is $\sim90\%$ during most high-rate calibrations. The combined DAQ system has collected more than 2 PB of both calibration and science data during the commissioning of XENONnT and the first science run.

Published
2022
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5. Low-energy Calibration of XENON1T with an Internal $^{37}$Ar Source

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Sanchez-Lucas, P., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., Zhu, T., Geppert, C., and Riemer, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A low-energy electronic recoil calibration of XENON1T, a dual-phase xenon time projection chamber, with an internal $^{37}$Ar source was performed. This calibration source features a 35-day half-life and provides two mono-energetic lines at 2.82 keV and 0.27 keV. The photon yield and electron yield at 2.82 keV are measured to be (32.3$\pm$0.3) photons/keV and (40.6$\pm$0.5) electrons/keV, respectively, in agreement with other measurements and with NEST predictions. The electron yield at 0.27 keV is also measured and it is (68.0$^{+6.3}_{-3.7}$) electrons/keV. The $^{37}$Ar calibration confirms that the detector is well-understood in the energy region close to the detection threshold, with the 2.82 keV line reconstructed at (2.83$\pm$0.02) keV, which further validates the model used to interpret the low-energy electronic recoil excess previously reported by XENON1T. The ability to efficiently remove argon with cryogenic distillation after the calibration proves that $^{37}$Ar can be considered as a regular calibration source for multi-tonne xenon detectors.

Published
2022
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6. Effective field theory and inelastic dark matter results from XENON1T

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

In this work, we expand on the XENON1T nuclear recoil searches to study the individual signals of dark matter interactions from operators up to dimension-eight in a Chiral Effective Field Theory (ChEFT) and a model of inelastic dark matter (iDM). We analyze data from two science runs of the XENON1T detector totaling 1\,tonne$\times$year exposure. For these analyses, we extended the region of interest from [4.9, 40.9]$\,$keV$_{\text{NR}}$ to [4.9, 54.4]$\,$keV$_{\text{NR}}$ to enhance our sensitivity for signals that peak at nonzero energies. We show that the data is consistent with the background-only hypothesis, with a small background over-fluctuation observed peaking between 20 and 50$\,$keV$_{\text{NR}}$, resulting in a maximum local discovery significance of 1.7\,$\sigma$ for the Vector$\otimes$Vector$_{\text{strange}}$ ($VV_s$) ChEFT channel for a dark matter particle of 70$\,$GeV/c$^2$, and $1.8\,\sigma$ for an iDM particle of 50$\,$GeV/c$^2$ with a mass splitting of 100$\,$keV/c$^2$. For each model, we report 90\,\% confidence level (CL) upper limits. We also report upper limits on three benchmark models of dark matter interaction using ChEFT where we investigate the effect of isospin-breaking interactions. We observe rate-driven cancellations in regions of the isospin-breaking couplings, leading to up to 6 orders of magnitude weaker upper limits with respect to the isospin-conserving case.

Published
2022
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7. An approximate likelihood for nuclear recoil searches with XENON1T data

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The XENON collaboration has published stringent limits on specific dark matter -nucleon recoil spectra from dark matter recoiling on the liquid xenon detector target. In this paper, we present an approximate likelihood for the XENON1T 1 tonne-year nuclear recoil search applicable to any nuclear recoil spectrum. Alongside this paper, we publish data and code to compute upper limits using the method we present. The approximate likelihood is constructed in bins of reconstructed energy, profiled along the signal expectation in each bin. This approach can be used to compute an approximate likelihood and therefore most statistical results for any nuclear recoil spectrum. Computing approximate results with this method is approximately three orders of magnitude faster than the likelihood used in the original publications of XENON1T, where limits were set for specific families of recoil spectra. Using this same method, we include toy Monte Carlo simulation-derived binwise likelihoods for the upcoming XENONnT experiment that can similarly be used to assess the sensitivity to arbitrary nuclear recoil signatures in its eventual 20 tonne-year exposure., Comment: Accepted by European Physical Journal C

Published
2022
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8. Search for New Physics in Electronic Recoil Data from XENONnT

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Gardner, R., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Paschos, P., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Stephen, J., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment
Abstract

We report on a blinded analysis of low-energy electronic-recoil data from the first science run of the XENONnT dark matter experiment. Novel subsystems and the increased 5.9 tonne liquid xenon target reduced the background in the (1, 30) keV search region to $(15.8 \pm 1.3)$ events/(tonne$\times$year$\times$keV), the lowest ever achieved in a dark matter detector and $\sim$5 times lower than in XENON1T. With an exposure of 1.16 tonne-years, we observe no excess above background and set stringent new limits on solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter., Comment: 10 pages, 6 figures. Data points are available in https://zenodo.org/record/7311940

Published
2022
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9. Double-Weak Decays of $^{124}$Xe and $^{136}$Xe in the XENON1T and XENONnT Experiments

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We present results on the search for double-electron capture ($2\nu\text{ECEC}$) of $^{124}$Xe and neutrinoless double-$\beta$ decay ($0\nu\beta\beta$) of $^{136}$Xe in XENON1T. We consider captures from the K- up to the N-shell in the $2\nu\text{ECEC}$ signal model and measure a total half-life of $T_{1/2}^{2\nu\text{ECEC}}=(1.1\pm0.2_\text{stat}\pm0.1_\text{sys})\times 10^{22}\;\text{yr}$ with a $0.87\;\text{kg}\times\text{yr}$ isotope exposure. The statistical significance of the signal is $7.0\,\sigma$. We use XENON1T data with $36.16\;\text{kg}\times\text{yr}$ of $^{136}$Xe exposure to search for $0\nu\beta\beta$. We find no evidence of a signal and set a lower limit on the half-life of $T_{1/2}^{0\nu\beta\beta} > 1.2 \times 10^{24}\;\text{yr}\; \text{at}\; 90\,\%\;\text{CL}$. This is the best result from a dark matter detector without an enriched target to date. We also report projections on the sensitivity of XENONnT to $0\nu\beta\beta$. Assuming a $275\;\text{kg}\times\text{yr}$ $^{136}$Xe exposure, the expected sensitivity is $T_{1/2}^{0\nu\beta\beta} > 2.1 \times 10^{25}\;\text{yr}\; \text{at}\; 90\,\%\;\text{CL}$, corresponding to an effective Majorana mass range of $\langle m_{\beta\beta} \rangle < (0.19 - 0.59)\;\text{eV/c}^2$., Comment: 23 pages, 14 figures, 9 tables, version accepted for publication in Phys. Rev. C

Published
2022
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10. A Next-Generation Liquid Xenon Observatory for Dark Matter and Neutrino Physics

Author

Aalbers, J., Abe, K., Aerne, V., Agostini, F., Maouloud, S. Ahmed, Akerib, D. S., Akimov, D. Yu., Akshat, J., Musalhi, A. K. Al, Alder, F., Alsum, S. K., Althueser, L., Amarasinghe, C. S., Amaro, F. D., Ames, A., Anderson, T. J., Andrieu, B., Angelides, N., Angelino, E., Angevaare, J., Antochi, V. C., Martin, D. Antón, Antunovic, B., Aprile, E., Araújo, H. M., Armstrong, J. E., Arneodo, F., Arthurs, M., Asadi, P., Baek, S., Bai, X., Bajpai, D., Baker, A., Balajthy, J., Balashov, S., Balzer, M., Bandyopadhyay, A., Bang, J., Barberio, E., Bargemann, J. W., Baudis, L., Bauer, D., Baur, D., Baxter, A., Baxter, A. L., Bazyk, M., Beattie, K., Behrens, J., Bell, N. F., Bellagamba, L., Beltrame, P., Benabderrahmane, M., Bernard, E. P., Bertone, G. F., Bhattacharjee, P., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Binau, A. R., Biondi, R., Biondi, Y., Birch, H. J., Bishara, F., Bismark, A., Blanco, C., Blockinger, G. M., Bodnia, E., Boehm, C., Bolozdynya, A. I., Bolton, P. D., Bottaro, S., Bourgeois, C., Boxer, B., Brás, P., Breskin, A., Breur, P. A., Brew, C. A. J., Brod, J., Brookes, E., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Burdin, S., Buse, S., Busenitz, J. K., Buttazzo, D., Buuck, M., Buzulutskov, A., Cabrita, R., Cai, C., Cai, D., Capelli, C., Cardoso, J. M. R., Carmona-Benitez, M. C., Cascella, M., Catena, R., Chakraborty, S., Chan, C., Chang, S., Chauvin, A., Chawla, A., Chen, H., Chepel, V., Chott, N. I., Cichon, D., Chavez, A. Cimental, Cimmino, B., Clark, M., Co, R. T., Colijn, A. P., Conrad, J., Converse, M. V., Costa, M., Cottle, A., Cox, G., Creaner, O., Garcia, J. J. Cuenca, Cussonneau, J. P., Cutter, J. E., Dahl, C. E., D'Andrea, V., David, A., Decowski, M. P., Dent, J. B., Deppisch, F. F., de Viveiros, L., Di Gangi, P., Di Giovanni, A., Di Pede, S., Dierle, J., Diglio, S., Dobson, J. E. Y., Doerenkamp, M., Douillet, D., Drexlin, G., Druszkiewicz, E., Dunsky, D., Eitel, K., Elykov, A., Emken, T., Engel, R., Eriksen, S. R., Fairbairn, M., Fan, A., Fan, J. J., Farrell, S. J., Fayer, S., Fearon, N. M., Ferella, A., Ferrari, C., Fieguth, A., Fiorucci, S., Fischer, H., Flaecher, H., Flierman, M., Florek, T., Foot, R., Fox, P. J., Franceschini, R., Fraser, E. D., Frenk, C. S., Frohlich, S., Fruth, T., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Gaitskell, R. J., Galloway, M., Gao, F., Garcia, I. Garcia, Genovesi, J., Ghag, C., Ghosh, S., Gibson, E., Gil, W., Giovagnoli, D., Girard, F., Glade-Beucke, R., Glück, F., Gokhale, S., de Gouvêa, A., Gráf, L., Grandi, L., Grigat, J., Grinstein, B., van der Grinten, M. G. D., Grössle, R., Guan, H., Guida, M., Gumbsheimer, R., Gwilliam, C. B., Hall, C. R., Hall, L. J., Hammann, R., Han, K., Hannen, V., Hansmann-Menzemer, S., Harata, R., Hardin, S. P., Hardy, E., Hardy, C. A., Harigaya, K., Harnik, R., Haselschwardt, S. J., Hernandez, M., Hertel, S. A., Higuera, A., Hils, C., Hochrein, S., Hoetzsch, L., Hoferichter, M., Hood, N., Hooper, D., Horn, M., Howlett, J., Huang, D. Q., Huang, Y., Hunt, D., Iacovacci, M., Iaquaniello, G., Ide, R., Ignarra, C. M., Iloglu, G., Itow, Y., Jacquet, E., Jahangir, O., Jakob, J., James, R. S., Jansen, A., Ji, W., Ji, X., Joerg, F., Johnson, J., Joy, A., Kaboth, A. C., Kamaha, A. C., Kanezaki, K., Kar, K., Kara, M., Kato, N., Kavrigin, P., Kazama, S., Keaveney, A. W., Kellerer, J., Khaitan, D., Khazov, A., Khundzakishvili, G., Khurana, I., Kilminster, B., Kleifges, M., Ko, P., Kobayashi, M., Kodroff, D., Koltmann, G., Kopec, A., Kopmann, A., Kopp, J., Korley, L., Kornoukhov, V. N., Korolkova, E. V., Kraus, H., Krauss, L. M., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Kuger, F., Kumar, J., Paredes, B. López, LaCascio, L., Laine, Q., Landsman, H., Lang, R. F., Leason, E. A., Lee, J., Leonard, D. S., Lesko, K. T., Levinson, L., Levy, C., Li, I., Li, S. C., Li, T., Liang, S., Liebenthal, C. S., Lin, J., Lin, Q., Lindemann, S., Lindner, M., Lindote, A., Linehan, R., Lippincott, W. H., Liu, X., Liu, K., Liu, J., Loizeau, J., Lombardi, F., Long, J., Lopes, M. I., Asamar, E. Lopez, Lorenzon, W., Lu, C., Luitz, S., Ma, Y., Machado, P. A. N., Macolino, C., Maeda, T., Mahlstedt, J., Majewski, P. A., Manalaysay, A., Mancuso, A., Manenti, L., Manfredini, A., Mannino, R. L., Marangou, N., March-Russell, J., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Martin, R., Martinez-Soler, I., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Mastronardi, M., Matias-Lopes, J. A., McCarthy, M. E., McFadden, N., McGinness, E., McKinsey, D. N., McLaughlin, J., McMichael, K., Meinhardt, P., Menéndez, J., Meng, Y., Messina, M., Midha, R., Milisavljevic, D., Miller, E. H., Milosevic, B., Milutinovic, S., Mitra, S. A., Miuchi, K., Mizrachi, E., Mizukoshi, K., Molinario, A., Monte, A., Monteiro, C. M. B., Monzani, M. E., Moore, J. S., Morå, K., Morad, J. A., Mendoza, J. D. Morales, Moriyama, S., Morrison, E., Morteau, E., Mosbacher, Y., Mount, B. J., Mueller, J., Murphy, A. St. J., Murra, M., Naim, D., Nakamura, S., Nash, E., Navaieelavasani, N., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Newstead, J. L., Ni, K., Nikoleyczik, J. A., Niro, V., Oberlack, U. G., Obradovic, M., Odgers, K., O'Hare, C. A. J., Oikonomou, P., Olcina, I., Oliver-Mallory, K., Oranday, A., Orpwood, J., Ostrovskiy, I., Ozaki, K., Paetsch, B., Pal, S., Palacio, J., Palladino, K. J., Palmer, J., Panci, P., Pandurovic, M., Parlati, A., Parveen, N., Patton, S. J., Pěč, V., Pellegrini, Q., Penning, B., Pereira, G., Peres, R., Perez-Gonzalez, Y., Perry, E., Pershing, T., Petrossian-Byrne, R., Pienaar, J., Piepke, A., Pieramico, G., Pierre, M., Piotter, M., Pizella, V., Plante, G., Pollmann, T., Porzio, D., Qi, J., Qie, Y., Qin, J., Raj, N., Silva, M. Rajado, Ramanathan, K., García, D. Ramírez, Ravanis, J., Redard-Jacot, L., Redigolo, D., Reichard, S., Reichenbacher, J., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rocchetti, A., Rosenfeld, S. L., Rosero, R., Rupp, N., Rushton, T., Saha, S., Sanchez, L., Sanchez-Lucas, P., Santone, D., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Sazzad, A. B. M. R., Scheibelhut, M., Schnee, R. W., Schrank, M., Schreiner, J., Schulte, P., Schulte, D., Eissing, H. Schulze, Schumann, M., Schwemberger, T., Schwenk, A., Schwetz, T., Lavina, L. Scotto, Scovell, P. R., Sekiya, H., Selvi, M., Semenov, E., Semeria, F., Shagin, P., Shaw, S., Shi, S., Shockley, E., Shutt, T. A., Si-Ahmed, R., Silk, J. J., Silva, C., Silva, M. C., Simgen, H., Šimkovic, F., Sinev, G., Singh, R., Skulski, W., Smirnov, J., Smith, R., Solmaz, M., Solovov, V. N., Sorensen, P., Soria, J., Sparmann, T. J., Stancu, I., Steidl, M., Stevens, A., Stifter, K., Strigari, L. E., Subotic, D., Suerfu, B., Suliga, A. M., Sumner, T. J., Szabo, P., Szydagis, M., Takeda, A., Takeuchi, Y., Tan, P. -L., Taricco, C., Taylor, W. C., Temples, D. J., Terliuk, A., Terman, P. A., Thers, D., Thieme, K., Thümmler, Th., Tiedt, D. R., Timalsina, M., To, W. H., Toennies, F., Tong, Z., Toschi, F., Tovey, D. R., Tranter, J., Trask, M., Trinchero, G. C., Tripathi, M., Tronstad, D. R., Trotta, R., Tsai, Y. D., Tunnell, C. D., Turner, W. G., Ueno, R., Urquijo, P., Utku, U., Vaitkus, A., Valerius, K., Vassilev, E., Vecchi, S., Velan, V., Vetter, S., Vincent, A. C., Vittorio, L., Volta, G., von Krosigk, B., von Piechowski, M., Vorkapic, D., Wagner, C. E. M., Wang, A. M., Wang, B., Wang, Y., Wang, W., Wang, J. J., Wang, L. -T., Wang, M., Watson, J. R., Wei, Y., Weinheimer, C., Weisman, E., Weiss, M., Wenz, D., West, S. M., Whitis, T. J., Williams, M., Wilson, M. J., Winkler, D., Wittweg, C., Wolf, J., Wolf, T., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Wu, V. H. S., Wu, P., Wüstling, S., Wurm, M., Xia, Q., Xiang, X., Xing, Y., Xu, J., Xu, Z., Xu, D., Yamashita, M., Yamazaki, R., Yan, H., Yang, L., Yang, Y., Ye, J., Yeh, M., Young, I., Yu, H. B., Yu, T. T., Yuan, L., Zavattini, G., Zerbo, S., Zhang, Y., Zhong, M., Zhou, N., Zhou, X., Zhu, T., Zhu, Y., Zhuang, Y., Zopounidis, J. P., Zuber, K., and Zupan, J.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon time-projection chamber is the leading technology to cover the available parameter space for Weakly Interacting Massive Particles (WIMPs), while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinoless double-beta decay and through a variety of astrophysical sources. A next-generation xenon-based detector will therefore be a true multi-purpose observatory to significantly advance particle physics, nuclear physics, astrophysics, solar physics, and cosmology. This review article presents the science cases for such a detector., Comment: 77 pages, 40 figures, 1262 references

Published
2022
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11. Application and modeling of an online distillation method to reduce krypton and argon in XENON1T

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Form, S., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hiraide, K., Hoetzsch, L., Howlett, J., Huhmann, C., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Ni, K., Oberlack, U., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sartorelli, G., Schreiner, J., Schulte, D., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Therreau, C., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Westermann, J., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., and Zopounidis, J. P.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A novel online distillation technique was developed for the XENON1T dark matter experiment to reduce intrinsic background components more volatile than xenon, such as krypton or argon, while the detector was operating. The method is based on a continuous purification of the gaseous volume of the detector system using the XENON1T cryogenic distillation column. A krypton-in-xenon concentration of $(360 \pm 60)$ ppq was achieved. It is the lowest concentration measured in the fiducial volume of an operating dark matter detector to date. A model was developed and fit to the data to describe the krypton evolution in the liquid and gas volumes of the detector system for several operation modes over the time span of 550 days, including the commissioning and science runs of XENON1T. The online distillation was also successfully applied to remove Ar-37 after its injection for a low energy calibration in XENON1T. This makes the usage of Ar-37 as a regular calibration source possible in the future. The online distillation can be applied to next-generation experiments to remove krypton prior to, or during, any science run. The model developed here allows further optimization of the distillation strategy for future large scale detectors.

Published
2021
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12. Emission of Single and Few Electrons in XENON1T and Limits on Light Dark Matter

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shenyang, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., and Zopounidis, J. P.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

Delayed single- and few-electron emissions plague dual-phase time projection chambers, limiting their potential to search for light-mass dark matter. This paper examines the origins of these events in the XENON1T experiment. Characterization of the intensity of delayed electron backgrounds shows that the resulting emissions are correlated, in time and position, with high-energy events and can effectively be vetoed. In this work we extend previous S2-only analyses down to a single electron. From this analysis, after removing the correlated backgrounds, we observe rates < 30 events/(electron*kg*day) in the region of interest spanning 1 to 5 electrons. We derive 90% confidence upper limits for dark matter-electron scattering, first direct limits on the electric dipole, magnetic dipole, and anapole interactions, and bosonic dark matter models, where we exclude new parameter space for dark photons and solar dark photons., Comment: 20 pages, 17 figures, Updated to correct published Solar Dark Photon limit

Published
2021
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13. Material radiopurity control in the XENONnT experiment

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hiraide, K., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Ni, K., Oberlack, U., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sartorelli, G., Schreiner, J., Schulte, D., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Therreau, C., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Westermann, J., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., Zopounidis, J. P., Laubenstein, M., and Nisi, S.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The selection of low-radioactive construction materials is of the utmost importance for rare-event searches and thus critical to the XENONnT experiment. Results of an extensive radioassay program are reported, in which material samples have been screened with gamma-ray spectroscopy, mass spectrometry, and $^{222}$Rn emanation measurements. Furthermore, the cleanliness procedures applied to remove or mitigate surface contamination of detector materials are described. Screening results, used as inputs for a XENONnT Monte Carlo simulation, predict a reduction of materials background ($\sim$17%) with respect to its predecessor XENON1T. Through radon emanation measurements, the expected $^{222}$Rn activity concentration in XENONnT is determined to be 4.2$\,(^{+0.5}_{-0.7})\,\mu$Bq/kg, a factor three lower with respect to XENON1T. This radon concentration will be further suppressed by means of the novel radon distillation system.

Published
2021
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14. Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: Insights from the START study

Author

Steering Committee, De Luca (Chairman), L., Gulizia (co-chairman), M.M., Temporelli, P.L., Riccio, C., Colivicchi, F., Amico, A.F., Formigli, D., Geraci, G., Di Lenarda, A., Executive Committee, De Luca, L., Maggioni, A.P., Lucci, D., Coordinating Center, Lorimer, A., Orsini, G., Gonzini, L., Fabbri, G., Priami, P., Maras, P., Ramani, F., Falcone, C., Passarelli, I., Mauri, S., Calabrò, P., Bianchi, R., Di Palma, G., Mascia, F., Vetrano, A., Fusco, A., Proia, E., Aiello, A., Tomai, F., Licitra, R., Petrolini, A., Bosco, B., Magliari, F., Callerame, M., Mazzella, T., Lettica, G.V., Coco, G., Incao, F., Marinacci, L., D'Addario, S., Tartaglione, S.N., Ubaldi, S., Sanchez, F.A., Costa, P., Manca, G., Failla, M., Scherillo, M., Procaccini, V., Senni, M., Luminita, E.M., Bonomo, P., Mossa, C., Corda, S., Colavita, A.R., Trevisonno, G., Vizzari, G., Cosentino, N., Formaro, C., Paolillo, C., Nalin, I.L., De Rosa, F.M., Fontana, F., Fuscaldo, G.F., Passamonti, E., Bertella, E., Calvaruso, E.V., Varani, E., Tani, F., Cicchitelli, G., Gabrielli, D., Paoloni, P., Marziali, A., Campo, G., Tebaldi, M., Biscaglia, S., Biase, M Di, Brunetti, N.D., Gallotta, A.M., Mattei, L., Marini, R., Balsemin, F., Urbano, M.D., Naio, R., Vicinelli, P., Arena, G., Mazzini, M., Gigli, N., Miserrafiti, B., Monopoli, A., Mortara, A., Delfino, P., Chioffi, M.M., Marino, P., Gravellone, M., Barbieri, L., Ledda, A., Carmina, M.G., Raisaro, A.E., Di Giacomo, C., Somaschini, A., Fasano, M.L., Sannazzaro, M., Arcieri, R., Pantaleoni, M., Leuzzi, C., Gorlato, G., Greco, G., Chiera, A., Ammaturo, T.A., Malanchini, G., Del Corral, M.P., Tedesco, L., Pede, S., Urso, L.G., Piscione, F., Galasso, G., Provasoli, S., Fattore, L., Lucca, G., Cresti, A., Cardillo, A., Fera, M.S., Vennettilli, F., Gaudio, C., Paravati, V., Caldarola, P., Locuratolo, N., Verlato, R., De Conti, F., Turiano, G., Preti, G., Moretti, L., Silenzi, S., Colonna, G., Picciolo, A., Nicosia, A., Cascone, C., Di Sciascio, G., Mangiacapra, F., Russo, A., Mastroianno, S., Esposito, G., Cosmi, F., D'Orazio, S., Costantini, C., Lanari, A., De Rosa, P., Esposito, L., Bilato, C., Valle, C Dalla, Ceresa, M., Colombo, E., Pennisi, V., Casciola, G., Driussi, M., Bisceglia, T., Scalvini, S., Rivadossi, F., Volpe, M., Comito, F., Scorzoni, D., Grimoldi, P., Lagioia, R., Santoro, D., De Cesare, N., Comotti, T., Poli, A., Martina, P., Musolino, M.F., Multari, E.I., Bilardo, G., Scalchi, G., Olivieri, C., Caranci, F., Pavan, D., Ganci, G., Mariani, A., Falchetti, E., Lanzillo, T., Caccavale, A., Bongo, A.S., Rizzi, A., Favilli, R., Maffei, S., Mallardo, M., Fulgione, C., Bordin, F., Bonmassari, R., Battaia, E., Puzzo, A., Vianello, G., D'Arpino, A., Romei, M., Pajes, G., Petronzelli, S., Ghezzi, F., Brigido, S., Pignatelli, L., Brscic, E., Sori, P., Russo, M., Biancolillo, E., Ignone, G., De Giorgio, N.A., Campaniello, C., Ponticelli, P., Margonato, A., Gerosa, S., Cutaia, A., Casalicchio, C., Bartolomucci, F., Larosa, C., Spadafina, T., Putignano, A., De Cristofaro, R., Bernardi, L., Sommariva, L., Celestini, A., Bertucci, C.M., Marchetti, M., Grisolia, E Franceschini, Ammendolea, C., Carini, M., Scipione, P., Politano, M., Rubino, G., Reina, C., Peccerillo, N., Paloscia, L., D'Alleva, A., Petacchi, R., Pignalosa, M., Lucchetti, D., Di Palma, F., La Mastra, R.A., Filippis, M De, Fontanella, B., Zanini, G., Casolo, G., Del Meglio, J., Parato, V.M., Genovesi, E., D'Alimonte, A., Miglioranza, A., Alessandri, N., Moscariello, F., Mauro, C., Sasso, A., Caso, P., Petrillo, C., Napoletano, C., Paparoni, S.R., Bernardo, V., Serdoz, R., Rotunno, R., Oppo, I., Aloisio, A., Aurelio, A., Licciardello, G., Cassaniti, L., Gulizia, M.M., Francese, G.M., Marcassa, C., Villani, R., Zorzoli, F., Mileto, F., Vecchis, M De, Scolozzi, D., Lupi, G., Caruso, D., Rebulla, E., La Fata, B., Anselmi, M., Girardi, P., Borruso, E., Ferrantelli, G., Sassone, B., Bressan, S., Capriolo, M., Pelissero, E., Piancastelli, M., Gobbi, M., Cocco, F., Bruno, M.G., Berti, S., Lo Surdo, G., Tanzi, P., De Rosa, R., Vilei, E., De Iaco, M.R., Grassi, G., Zanella, C., Marullo, L., Alfano, G., Pelaggi, P., Talarico, R., Tuccillo, B., Irace, L., Proietti, F., Di Croce, G., Di Lorenzo, L., Zarrilli, A., Bongini, M., Ranise, A., Aprile, A., Fornengo, C., Capogrosso, V., Tranghese, A., Golia, B., Marziano, A., Roncon, L., Picariello, C., Bagni, E., Leci, E., Gregorio, G., Gatto, F., Piemonte, F., Gervasio, F., Navazio, A., Guerri, E., Belmonte, E., Marino, F., Di Belardino, N., Di Nuzzo, M.R., Epifani, M., Comolatti, G., Conconi, B., Benea, D., Casu, G., Merella, P., Ammirati, M.A., Corrado, V.M., Spagnolo, D., Caico, S.I., Bonizzato, S., Margheri, M., Corrado, L., Antonicelli, R., Ferrigno, C., Merlino, A., Nassiacos, D., Antonelli, A., Marchese, A., Uguccioni, M., Villella, A., Bechi, S., Lo Bianco, F., Bedogni, F., Negro, L., Donato, L., Statile, D., Cassin, M., Fedele, F., Granatelli, A., Calcagno, S., Politi, A., Pani, A., De Luca, Leonardo, Temporelli, Pier Luigi, Gulizia, Michele Massimo, Gonzini, Lucio, Ammaturo, Tiziana Anita, Tedesco, Luigi, Pede, Silvia, Oliva, Fabrizio, Gabrielli, Domenico, Colivicchi, Furio, and Averna, Maurizio R.

Published
2023
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15. Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: Insights from the START study

Author

De Luca, L, Temporelli, P, Gulizia, M, Gonzini, L, Ammaturo, T, Tedesco, L, Pede, S, Oliva, F, Gabrielli, D, Colivicchi, F, Averna, M, Steering, C, Gulizia (co-chairman), M, Riccio, C, Amico, A, Formigli, D, Geraci, G, Di Lenarda, A, Executive, C, Maggioni, A, Lucci, D, Coordinating, C, Lorimer, A, Orsini, G, Fabbri, G, Priami, P, Maras, P, Ramani, F, Falcone, C, Passarelli, I, Mauri, S, Calabro, P, Bianchi, R, Di Palma, G, Mascia, F, Vetrano, A, Fusco, A, Proia, E, Aiello, A, Tomai, F, Licitra, R, Petrolini, A, Bosco, B, Magliari, F, Callerame, M, Mazzella, T, Lettica, G, Coco, G, Incao, F, Marinacci, L, D'Addario, S, Tartaglione, S, Ubaldi, S, Sanchez, F, Costa, P, Manca, G, Failla, M, Scherillo, M, Procaccini, V, Senni, M, Luminita, E, Bonomo, P, Mossa, C, Corda, S, Colavita, A, Trevisonno, G, Vizzari, G, Cosentino, N, Formaro, C, Paolillo, C, Nalin, I, De Rosa, F, Fontana, F, Fuscaldo, G, Passamonti, E, Bertella, E, Calvaruso, E, Varani, E, Tani, F, Cicchitelli, G, Paoloni, P, Marziali, A, Campo, G, Tebaldi, M, Biscaglia, S, Biase, M, Brunetti, N, Gallotta, A, Mattei, L, Marini, R, Balsemin, F, Urbano, M, Naio, R, Vicinelli, P, Arena, G, Mazzini, M, Gigli, N, Miserrafiti, B, Monopoli, A, Mortara, A, Delfino, P, Chioffi, M, Marino, P, Gravellone, M, Barbieri, L, Ledda, A, Carmina, M, Raisaro, A, Di Giacomo, C, Somaschini, A, Fasano, M, Sannazzaro, M, Arcieri, R, Pantaleoni, M, Leuzzi, C, Gorlato, G, Greco, G, Chiera, A, Malanchini, G, Del Corral, M, Urso, L, Piscione, F, Galasso, G, Provasoli, S, Fattore, L, Lucca, G, Cresti, A, Cardillo, A, Fera, M, Vennettilli, F, Gaudio, C, Paravati, V, Caldarola, P, Locuratolo, N, Verlato, R, De Conti, F, Turiano, G, Preti, G, Moretti, L, Silenzi, S, Colonna, G, Picciolo, A, Nicosia, A, Cascone, C, Di Sciascio, G, Mangiacapra, F, Russo, A, Mastroianno, S, Esposito, G, Cosmi, F, D'Orazio, S, Costantini, C, Lanari, A, De Rosa, P, Esposito, L, Bilato, C, Valle, C, Ceresa, M, Colombo, E, Pennisi, V, Casciola, G, Driussi, M, Bisceglia, T, Scalvini, S, Rivadossi, F, Volpe, M, Comito, F, Scorzoni, D, Grimoldi, P, Lagioia, R, Santoro, D, De Cesare, N, Comotti, T, Poli, A, Martina, P, Musolino, M, Multari, E, Bilardo, G, Scalchi, G, Olivieri, C, Caranci, F, Pavan, D, Ganci, G, Mariani, A, Falchetti, E, Lanzillo, T, Caccavale, A, Bongo, A, Rizzi, A, Favilli, R, Maffei, S, Mallardo, M, Fulgione, C, Bordin, F, Bonmassari, R, Battaia, E, Puzzo, A, Vianello, G, D'Arpino, A, Romei, M, Pajes, G, Petronzelli, S, Ghezzi, F, Brigido, S, Pignatelli, L, Brscic, E, Sori, P, Russo, M, Biancolillo, E, Ignone, G, De Giorgio, N, Campaniello, C, Ponticelli, P, Margonato, A, Gerosa, S, Cutaia, A, Casalicchio, C, Bartolomucci, F, Larosa, C, Spadafina, T, Putignano, A, De Cristofaro, R, Bernardi, L, Sommariva, L, Celestini, A, Bertucci, C, Marchetti, M, Grisolia, E, Ammendolea, C, Carini, M, Scipione, P, Politano, M, Rubino, G, Reina, C, Peccerillo, N, Paloscia, L, D'Alleva, A, Petacchi, R, Pignalosa, M, Lucchetti, D, Di Palma, F, La Mastra, R, Filippis, M, Fontanella, B, Zanini, G, Casolo, G, Del Meglio, J, Parato, V, Genovesi, E, D'Alimonte, A, Miglioranza, A, Alessandri, N, Moscariello, F, Mauro, C, Sasso, A, Caso, P, Petrillo, C, Napoletano, C, Paparoni, S, Bernardo, V, Serdoz, R, Rotunno, R, Oppo, I, Aloisio, A, Aurelio, A, Licciardello, G, Cassaniti, L, Francese, G, Marcassa, C, Villani, R, Zorzoli, F, Mileto, F, Vecchis, M, Scolozzi, D, Lupi, G, Caruso, D, Rebulla, E, La Fata, B, Anselmi, M, Girardi, P, Borruso, E, Ferrantelli, G, Sassone, B, Bressan, S, Capriolo, M, Pelissero, E, Piancastelli, M, Gobbi, M, Cocco, F, Bruno, M, Berti, S, Lo Surdo, G, Tanzi, P, De Rosa, R, Vilei, E, De Iaco, M, Grassi, G, Zanella, C, Marullo, L, Alfano, G, Pelaggi, P, Talarico, R, Tuccillo, B, Irace, L, Proietti, F, Di Croce, G, Di Lorenzo, L, Zarrilli, A, Bongini, M, Ranise, A, Aprile, A, Fornengo, C, Capogrosso, V, Tranghese, A, Golia, B, Marziano, A, Roncon, L, Picariello, C, Bagni, E, Leci, E, Gregorio, G, Gatto, F, Piemonte, F, Gervasio, F, Navazio, A, Guerri, E, Belmonte, E, Marino, F, Di Belardino, N, Di Nuzzo, M, Epifani, M, Comolatti, G, Conconi, B, Benea, D, Casu, G, Merella, P, Ammirati, M, Corrado, V, Spagnolo, D, Caico, S, Bonizzato, S, Margheri, M, Corrado, L, Antonicelli, R, Ferrigno, C, Merlino, A, Nassiacos, D, Antonelli, A, Marchese, A, Uguccioni, M, Villella, A, Bechi, S, Lo Bianco, F, Bedogni, F, Negro, L, Donato, L, Statile, D, Cassin, M, Fedele, F, Granatelli, A, Calcagno, S, Politi, A, Pani, A, De Luca L., Temporelli P. L., Gulizia M. M., Gonzini L., Ammaturo T. A., Tedesco L., Pede S., Oliva F., Gabrielli D., Colivicchi F., Averna M. R., Steering Committee, Gulizia (co-chairman) M. M., Riccio C., Amico A. F., Formigli D., Geraci G., Di Lenarda A., Executive Committee, Maggioni A. P., Lucci D., Coordinating Center, Lorimer A., Orsini G., Fabbri G., Priami P., Maras P., Ramani F., Falcone C., Passarelli I., Mauri S., Calabro P., Bianchi R., Di Palma G., Mascia F., Vetrano A., Fusco A., Proia E., Aiello A., Tomai F., Licitra R., Petrolini A., Bosco B., Magliari F., Callerame M., Mazzella T., Lettica G. V., Coco G., Incao F., Marinacci L., D'Addario S., Tartaglione S. N., Ubaldi S., Sanchez F. A., Costa P., Manca G., Failla M., Scherillo M., Procaccini V., Senni M., Luminita E. M., Bonomo P., Mossa C., Corda S., Colavita A. R., Trevisonno G., Vizzari G., Cosentino N., Formaro C., Paolillo C., Nalin I. L., De Rosa F. M., Fontana F., Fuscaldo G. F., Passamonti E., Bertella E., Calvaruso E. V., Varani E., Tani F., Cicchitelli G., Paoloni P., Marziali A., Campo G., Tebaldi M., Biscaglia S., Biase M. D., Brunetti N. D., Gallotta A. M., Mattei L., Marini R., Balsemin F., Urbano M. D., Naio R., Vicinelli P., Arena G., Mazzini M., Gigli N., Miserrafiti B., Monopoli A., Mortara A., Delfino P., Chioffi M. M., Marino P., Gravellone M., Barbieri L., Ledda A., Carmina M. G., Raisaro A. E., Di Giacomo C., Somaschini A., Fasano M. L., Sannazzaro M., Arcieri R., Pantaleoni M., Leuzzi C., Gorlato G., Greco G., Chiera A., Malanchini G., Del Corral M. P., Urso L. G., Piscione F., Galasso G., Provasoli S., Fattore L., Lucca G., Cresti A., Cardillo A., Fera M. S., Vennettilli F., Gaudio C., Paravati V., Caldarola P., Locuratolo N., Verlato R., De Conti F., Turiano G., Preti G., Moretti L., Silenzi S., Colonna G., Picciolo A., Nicosia A., Cascone C., Di Sciascio G., Mangiacapra F., Russo A., Mastroianno S., Esposito G., Cosmi F., D'Orazio S., Costantini C., Lanari A., De Rosa P., Esposito L., Bilato C., Valle C. D., Ceresa M., Colombo E., Pennisi V., Casciola G., Driussi M., Bisceglia T., Scalvini S., Rivadossi F., Volpe M., Comito F., Scorzoni D., Grimoldi P., Lagioia R., Santoro D., De Cesare N., Comotti T., Poli A., Martina P., Musolino M. F., Multari E. I., Bilardo G., Scalchi G., Olivieri C., Caranci F., Pavan D., Ganci G., Mariani A., Falchetti E., Lanzillo T., Caccavale A., Bongo A. S., Rizzi A., Favilli R., Maffei S., Mallardo M., Fulgione C., Bordin F., Bonmassari R., Battaia E., Puzzo A., Vianello G., D'Arpino A., Romei M., Pajes G., Petronzelli S., Ghezzi F., Brigido S., Pignatelli L., Brscic E., Sori P., Russo M., Biancolillo E., Ignone G., De Giorgio N. A., Campaniello C., Ponticelli P., Margonato A., Gerosa S., Cutaia A., Casalicchio C., Bartolomucci F., Larosa C., Spadafina T., Putignano A., De Cristofaro R., Bernardi L., Sommariva L., Celestini A., Bertucci C. M., Marchetti M., Grisolia E. F., Ammendolea C., Carini M., Scipione P., Politano M., Rubino G., Reina C., Peccerillo N., Paloscia L., D'Alleva A., Petacchi R., Pignalosa M., Lucchetti D., Di Palma F., La Mastra R. A., Filippis M. D., Fontanella B., Zanini G., Casolo G., Del Meglio J., Parato V. M., Genovesi E., D'Alimonte A., Miglioranza A., Alessandri N., Moscariello F., Mauro C., Sasso A., Caso P., Petrillo C., Napoletano C., Paparoni S. R., Bernardo V., Serdoz R., Rotunno R., Oppo I., Aloisio A., Aurelio A., Licciardello G., Cassaniti L., Francese G. M., Marcassa C., Villani R., Zorzoli F., Mileto F., Vecchis M. D., Scolozzi D., Lupi G., Caruso D., Rebulla E., La Fata B., Anselmi M., Girardi P., Borruso E., Ferrantelli G., Sassone B., Bressan S., Capriolo M., Pelissero E., Piancastelli M., Gobbi M., Cocco F., Bruno M. G., Berti S., Lo Surdo G., Tanzi P., De Rosa R., Vilei E., De Iaco M. R., Grassi G., Zanella C., Marullo L., Alfano G., Pelaggi P., Talarico R., Tuccillo B., Irace L., Proietti F., Di Croce G., Di Lorenzo L., Zarrilli A., Bongini M., Ranise A., Aprile A., Fornengo C., Capogrosso V., Tranghese A., Golia B., Marziano A., Roncon L., Picariello C., Bagni E., Leci E., Gregorio G., Gatto F., Piemonte F., Gervasio F., Navazio A., Guerri E., Belmonte E., Marino F., Di Belardino N., Di Nuzzo M. R., Epifani M., Comolatti G., Conconi B., Benea D., Casu G., Merella P., Ammirati M. A., Corrado V. M., Spagnolo D., Caico S. I., Bonizzato S., Margheri M., Corrado L., Antonicelli R., Ferrigno C., Merlino A., Nassiacos D., Antonelli A., Marchese A., Uguccioni M., Villella A., Bechi S., Lo Bianco F., Bedogni F., Negro L., Donato L., Statile D., Cassin M., Fedele F., Granatelli A., Calcagno S., Politi A., Pani A., De Luca, L, Temporelli, P, Gulizia, M, Gonzini, L, Ammaturo, T, Tedesco, L, Pede, S, Oliva, F, Gabrielli, D, Colivicchi, F, Averna, M, Steering, C, Gulizia (co-chairman), M, Riccio, C, Amico, A, Formigli, D, Geraci, G, Di Lenarda, A, Executive, C, Maggioni, A, Lucci, D, Coordinating, C, Lorimer, A, Orsini, G, Fabbri, G, Priami, P, Maras, P, Ramani, F, Falcone, C, Passarelli, I, Mauri, S, Calabro, P, Bianchi, R, Di Palma, G, Mascia, F, Vetrano, A, Fusco, A, Proia, E, Aiello, A, Tomai, F, Licitra, R, Petrolini, A, Bosco, B, Magliari, F, Callerame, M, Mazzella, T, Lettica, G, Coco, G, Incao, F, Marinacci, L, D'Addario, S, Tartaglione, S, Ubaldi, S, Sanchez, F, Costa, P, Manca, G, Failla, M, Scherillo, M, Procaccini, V, Senni, M, Luminita, E, Bonomo, P, Mossa, C, Corda, S, Colavita, A, Trevisonno, G, Vizzari, G, Cosentino, N, Formaro, C, Paolillo, C, Nalin, I, De Rosa, F, Fontana, F, Fuscaldo, G, Passamonti, E, Bertella, E, Calvaruso, E, Varani, E, Tani, F, Cicchitelli, G, Paoloni, P, Marziali, A, Campo, G, Tebaldi, M, Biscaglia, S, Biase, M, Brunetti, N, Gallotta, A, Mattei, L, Marini, R, Balsemin, F, Urbano, M, Naio, R, Vicinelli, P, Arena, G, Mazzini, M, Gigli, N, Miserrafiti, B, Monopoli, A, Mortara, A, Delfino, P, Chioffi, M, Marino, P, Gravellone, M, Barbieri, L, Ledda, A, Carmina, M, Raisaro, A, Di Giacomo, C, Somaschini, A, Fasano, M, Sannazzaro, M, Arcieri, R, Pantaleoni, M, Leuzzi, C, Gorlato, G, Greco, G, Chiera, A, Malanchini, G, Del Corral, M, Urso, L, Piscione, F, Galasso, G, Provasoli, S, Fattore, L, Lucca, G, Cresti, A, Cardillo, A, Fera, M, Vennettilli, F, Gaudio, C, Paravati, V, Caldarola, P, Locuratolo, N, Verlato, R, De Conti, F, Turiano, G, Preti, G, Moretti, L, Silenzi, S, Colonna, G, Picciolo, A, Nicosia, A, Cascone, C, Di Sciascio, G, Mangiacapra, F, Russo, A, Mastroianno, S, Esposito, G, Cosmi, F, D'Orazio, S, Costantini, C, Lanari, A, De Rosa, P, Esposito, L, Bilato, C, Valle, C, Ceresa, M, Colombo, E, Pennisi, V, Casciola, G, Driussi, M, Bisceglia, T, Scalvini, S, Rivadossi, F, Volpe, M, Comito, F, Scorzoni, D, Grimoldi, P, Lagioia, R, Santoro, D, De Cesare, N, Comotti, T, Poli, A, Martina, P, Musolino, M, Multari, E, Bilardo, G, Scalchi, G, Olivieri, C, Caranci, F, Pavan, D, Ganci, G, Mariani, A, Falchetti, E, Lanzillo, T, Caccavale, A, Bongo, A, Rizzi, A, Favilli, R, Maffei, S, Mallardo, M, Fulgione, C, Bordin, F, Bonmassari, R, Battaia, E, Puzzo, A, Vianello, G, D'Arpino, A, Romei, M, Pajes, G, Petronzelli, S, Ghezzi, F, Brigido, S, Pignatelli, L, Brscic, E, Sori, P, Russo, M, Biancolillo, E, Ignone, G, De Giorgio, N, Campaniello, C, Ponticelli, P, Margonato, A, Gerosa, S, Cutaia, A, Casalicchio, C, Bartolomucci, F, Larosa, C, Spadafina, T, Putignano, A, De Cristofaro, R, Bernardi, L, Sommariva, L, Celestini, A, Bertucci, C, Marchetti, M, Grisolia, E, Ammendolea, C, Carini, M, Scipione, P, Politano, M, Rubino, G, Reina, C, Peccerillo, N, Paloscia, L, D'Alleva, A, Petacchi, R, Pignalosa, M, Lucchetti, D, Di Palma, F, La Mastra, R, Filippis, M, Fontanella, B, Zanini, G, Casolo, G, Del Meglio, J, Parato, V, Genovesi, E, D'Alimonte, A, Miglioranza, A, Alessandri, N, Moscariello, F, Mauro, C, Sasso, A, Caso, P, Petrillo, C, Napoletano, C, Paparoni, S, Bernardo, V, Serdoz, R, Rotunno, R, Oppo, I, Aloisio, A, Aurelio, A, Licciardello, G, Cassaniti, L, Francese, G, Marcassa, C, Villani, R, Zorzoli, F, Mileto, F, Vecchis, M, Scolozzi, D, Lupi, G, Caruso, D, Rebulla, E, La Fata, B, Anselmi, M, Girardi, P, Borruso, E, Ferrantelli, G, Sassone, B, Bressan, S, Capriolo, M, Pelissero, E, Piancastelli, M, Gobbi, M, Cocco, F, Bruno, M, Berti, S, Lo Surdo, G, Tanzi, P, De Rosa, R, Vilei, E, De Iaco, M, Grassi, G, Zanella, C, Marullo, L, Alfano, G, Pelaggi, P, Talarico, R, Tuccillo, B, Irace, L, Proietti, F, Di Croce, G, Di Lorenzo, L, Zarrilli, A, Bongini, M, Ranise, A, Aprile, A, Fornengo, C, Capogrosso, V, Tranghese, A, Golia, B, Marziano, A, Roncon, L, Picariello, C, Bagni, E, Leci, E, Gregorio, G, Gatto, F, Piemonte, F, Gervasio, F, Navazio, A, Guerri, E, Belmonte, E, Marino, F, Di Belardino, N, Di Nuzzo, M, Epifani, M, Comolatti, G, Conconi, B, Benea, D, Casu, G, Merella, P, Ammirati, M, Corrado, V, Spagnolo, D, Caico, S, Bonizzato, S, Margheri, M, Corrado, L, Antonicelli, R, Ferrigno, C, Merlino, A, Nassiacos, D, Antonelli, A, Marchese, A, Uguccioni, M, Villella, A, Bechi, S, Lo Bianco, F, Bedogni, F, Negro, L, Donato, L, Statile, D, Cassin, M, Fedele, F, Granatelli, A, Calcagno, S, Politi, A, Pani, A, De Luca L., Temporelli P. L., Gulizia M. M., Gonzini L., Ammaturo T. A., Tedesco L., Pede S., Oliva F., Gabrielli D., Colivicchi F., Averna M. R., Steering Committee, Gulizia (co-chairman) M. M., Riccio C., Amico A. F., Formigli D., Geraci G., Di Lenarda A., Executive Committee, Maggioni A. P., Lucci D., Coordinating Center, Lorimer A., Orsini G., Fabbri G., Priami P., Maras P., Ramani F., Falcone C., Passarelli I., Mauri S., Calabro P., Bianchi R., Di Palma G., Mascia F., Vetrano A., Fusco A., Proia E., Aiello A., Tomai F., Licitra R., Petrolini A., Bosco B., Magliari F., Callerame M., Mazzella T., Lettica G. V., Coco G., Incao F., Marinacci L., D'Addario S., Tartaglione S. N., Ubaldi S., Sanchez F. A., Costa P., Manca G., Failla M., Scherillo M., Procaccini V., Senni M., Luminita E. M., Bonomo P., Mossa C., Corda S., Colavita A. R., Trevisonno G., Vizzari G., Cosentino N., Formaro C., Paolillo C., Nalin I. L., De Rosa F. M., Fontana F., Fuscaldo G. F., Passamonti E., Bertella E., Calvaruso E. V., Varani E., Tani F., Cicchitelli G., Paoloni P., Marziali A., Campo G., Tebaldi M., Biscaglia S., Biase M. D., Brunetti N. D., Gallotta A. M., Mattei L., Marini R., Balsemin F., Urbano M. D., Naio R., Vicinelli P., Arena G., Mazzini M., Gigli N., Miserrafiti B., Monopoli A., Mortara A., Delfino P., Chioffi M. M., Marino P., Gravellone M., Barbieri L., Ledda A., Carmina M. G., Raisaro A. E., Di Giacomo C., Somaschini A., Fasano M. L., Sannazzaro M., Arcieri R., Pantaleoni M., Leuzzi C., Gorlato G., Greco G., Chiera A., Malanchini G., Del Corral M. P., Urso L. G., Piscione F., Galasso G., Provasoli S., Fattore L., Lucca G., Cresti A., Cardillo A., Fera M. S., Vennettilli F., Gaudio C., Paravati V., Caldarola P., Locuratolo N., Verlato R., De Conti F., Turiano G., Preti G., Moretti L., Silenzi S., Colonna G., Picciolo A., Nicosia A., Cascone C., Di Sciascio G., Mangiacapra F., Russo A., Mastroianno S., Esposito G., Cosmi F., D'Orazio S., Costantini C., Lanari A., De Rosa P., Esposito L., Bilato C., Valle C. D., Ceresa M., Colombo E., Pennisi V., Casciola G., Driussi M., Bisceglia T., Scalvini S., Rivadossi F., Volpe M., Comito F., Scorzoni D., Grimoldi P., Lagioia R., Santoro D., De Cesare N., Comotti T., Poli A., Martina P., Musolino M. F., Multari E. I., Bilardo G., Scalchi G., Olivieri C., Caranci F., Pavan D., Ganci G., Mariani A., Falchetti E., Lanzillo T., Caccavale A., Bongo A. S., Rizzi A., Favilli R., Maffei S., Mallardo M., Fulgione C., Bordin F., Bonmassari R., Battaia E., Puzzo A., Vianello G., D'Arpino A., Romei M., Pajes G., Petronzelli S., Ghezzi F., Brigido S., Pignatelli L., Brscic E., Sori P., Russo M., Biancolillo E., Ignone G., De Giorgio N. A., Campaniello C., Ponticelli P., Margonato A., Gerosa S., Cutaia A., Casalicchio C., Bartolomucci F., Larosa C., Spadafina T., Putignano A., De Cristofaro R., Bernardi L., Sommariva L., Celestini A., Bertucci C. M., Marchetti M., Grisolia E. F., Ammendolea C., Carini M., Scipione P., Politano M., Rubino G., Reina C., Peccerillo N., Paloscia L., D'Alleva A., Petacchi R., Pignalosa M., Lucchetti D., Di Palma F., La Mastra R. A., Filippis M. D., Fontanella B., Zanini G., Casolo G., Del Meglio J., Parato V. M., Genovesi E., D'Alimonte A., Miglioranza A., Alessandri N., Moscariello F., Mauro C., Sasso A., Caso P., Petrillo C., Napoletano C., Paparoni S. R., Bernardo V., Serdoz R., Rotunno R., Oppo I., Aloisio A., Aurelio A., Licciardello G., Cassaniti L., Francese G. M., Marcassa C., Villani R., Zorzoli F., Mileto F., Vecchis M. D., Scolozzi D., Lupi G., Caruso D., Rebulla E., La Fata B., Anselmi M., Girardi P., Borruso E., Ferrantelli G., Sassone B., Bressan S., Capriolo M., Pelissero E., Piancastelli M., Gobbi M., Cocco F., Bruno M. G., Berti S., Lo Surdo G., Tanzi P., De Rosa R., Vilei E., De Iaco M. R., Grassi G., Zanella C., Marullo L., Alfano G., Pelaggi P., Talarico R., Tuccillo B., Irace L., Proietti F., Di Croce G., Di Lorenzo L., Zarrilli A., Bongini M., Ranise A., Aprile A., Fornengo C., Capogrosso V., Tranghese A., Golia B., Marziano A., Roncon L., Picariello C., Bagni E., Leci E., Gregorio G., Gatto F., Piemonte F., Gervasio F., Navazio A., Guerri E., Belmonte E., Marino F., Di Belardino N., Di Nuzzo M. R., Epifani M., Comolatti G., Conconi B., Benea D., Casu G., Merella P., Ammirati M. A., Corrado V. M., Spagnolo D., Caico S. I., Bonizzato S., Margheri M., Corrado L., Antonicelli R., Ferrigno C., Merlino A., Nassiacos D., Antonelli A., Marchese A., Uguccioni M., Villella A., Bechi S., Lo Bianco F., Bedogni F., Negro L., Donato L., Statile D., Cassin M., Fedele F., Granatelli A., Calcagno S., Politi A., and Pani A.

Abstract

Background and aim: Elevated triglyceride (TG) levels seem to identify subjects at increased cardiovascular risk, independent of LDL-C levels. We sought to evaluate the predictive role of hypertriglyceridemia, defined as TG levels ≥150 mg/dl, in very high risk (VHR) patients with chronic coronary syndromes (CCS) treated with statins. Methods and results: Using the data from the STable Coronary Artery Diseases RegisTry (START) study, an Italian nationwide registry, we assessed the association between the TG levels and baseline clinical characteristics, pharmacological treatment and major adverse cardio-cerebrovascular events (MACCE) at 1 year in a large cohort of statin-treated patients at VHR. Of the 4751 consecutive patients with CCS enrolled in the registry and classified as VHR, 2652 (55.8%) had TG values available (mean 120.6 ± 54.9) and were treated with at least a statin at baseline: 2019 (76.1%) with TG < 150 and 633 (23.9%) with TG ≥ 150 mg/dl. At 1 year from enrolment, MACCE occurred in 168 (6.3%) patients, without differences between the two groups of TG (5.9 vs 7.6%; p = 0.14). At multivariable analysis, hypertriglyceridemia did not result as independent predictor of the MACCE (hazard ratio: 1.16; 95% confidence intervals: 0.82–1.64; p = 0.42). Conclusions: In the present large, nationwide cohort of consecutive CCS patients at VHR with statin-controlled LDL-C levels, hypertriglyceridemia was present in around 24% of cases and did not result as predictor of MACCE at 1 year. Further studies with a longer follow-up and larger sample size are needed to better define the prognostic role of TG levels when intensive LDL lowering therapies are used.

Published
2023

16. Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: insights from the START Study

Author

De Luca, Leonardo, primary, Temporelli, Pier Luigi, additional, Gulizia, Michele Massimo, additional, Gonzini, Lucio, additional, Ammaturo, Tiziana Anita, additional, Tedesco, Luigi, additional, Pede, Silvia, additional, Oliva, Fabrizio, additional, Gabrielli, Domenico, additional, Colivicchi, Furio, additional, Averna, Maurizio R., additional, De Luca, L., additional, Gulizia, M.M., additional, Temporelli, P.L., additional, Riccio, C., additional, Colivicchi, F., additional, Amico, A.F., additional, Formigli, D., additional, Geraci, G., additional, Di Lenarda, A., additional, Maggioni, A.P., additional, Lucci, D., additional, Lorimer, A., additional, Orsini, G., additional, Gonzini, L., additional, Fabbri, G., additional, Priami, P., additional, Maras, P., additional, Ramani, F., additional, Falcone, C., additional, Passarelli, I., additional, Mauri, S., additional, Calabrò, P., additional, Bianchi, R., additional, Di Palma, G., additional, Mascia, F., additional, Vetrano, A., additional, Fusco, A., additional, Proia, E., additional, Aiello, A., additional, Tomai, F., additional, Licitra, R., additional, Petrolini, A., additional, Bosco, B., additional, Magliari, F., additional, Callerame, M., additional, Mazzella, T., additional, Lettica, G.V., additional, Coco, G., additional, Incao, F., additional, Marinacci, L., additional, D'Addario, S., additional, Tartaglione, S.N., additional, Ubaldi, S., additional, Sanchez, F.A., additional, Costa, P., additional, Manca, G., additional, Failla, M., additional, Scherillo, M., additional, Procaccini, V., additional, Senni, M., additional, Luminita, E.M., additional, Bonomo, P., additional, Mossa, C., additional, Corda, S., additional, Colavita, A.R., additional, Trevisonno, G., additional, Vizzari, G., additional, Cosentino, N., additional, Formaro, C., additional, Paolillo, C., additional, Nalin, I.L., additional, De Rosa, F.M., additional, Fontana, F., additional, Fuscaldo, G.F., additional, Passamonti, E., additional, Bertella, E., additional, Calvaruso, E.V., additional, Varani, E., additional, Tani, F., additional, Cicchitelli, G., additional, Gabrielli, D., additional, Paoloni, P., additional, Marziali, A., additional, Campo, G., additional, Tebaldi, M., additional, Biscaglia, S., additional, Biase, M Di, additional, Brunetti, N.D., additional, Gallotta, A.M., additional, Mattei, L., additional, Marini, R., additional, Balsemin, F., additional, Urbano, M.D., additional, Naio, R., additional, Vicinelli, P., additional, Arena, G., additional, Mazzini, M., additional, Gigli, N., additional, Miserrafiti, B., additional, Monopoli, A., additional, Mortara, A., additional, Delfino, P., additional, Chioffi, M.M., additional, Marino, P., additional, Gravellone, M., additional, Barbieri, L., additional, Ledda, A., additional, Carmina, M.G., additional, Raisaro, A.E., additional, Di Giacomo, C., additional, Somaschini, A., additional, Fasano, M.L., additional, Sannazzaro, M., additional, Arcieri, R., additional, Pantaleoni, M., additional, Leuzzi, C., additional, Gorlato, G., additional, Greco, G., additional, Chiera, A., additional, Ammaturo, T.A., additional, Malanchini, G., additional, Del Corral, M.P., additional, Tedesco, L., additional, Pede, S., additional, Urso, L.G., additional, Piscione, F., additional, Galasso, G., additional, Provasoli, S., additional, Fattore, L., additional, Lucca, G., additional, Cresti, A., additional, Cardillo, A., additional, Fera, M.S., additional, Vennettilli, F., additional, Gaudio, C., additional, Paravati, V., additional, Caldarola, P., additional, Locuratolo, N., additional, Verlato, R., additional, De Conti, F., additional, Turiano, G., additional, Preti, G., additional, Moretti, L., additional, Silenzi, S., additional, Colonna, G., additional, Picciolo, A., additional, Nicosia, A., additional, Cascone, C., additional, Di Sciascio, G., additional, Mangiacapra, F., additional, Russo, A., additional, Mastroianno, S., additional, Esposito, G., additional, Cosmi, F., additional, D'Orazio, S., additional, Costantini, C., additional, Lanari, A., additional, De Rosa, P., additional, Esposito, L., additional, Bilato, C., additional, Valle, C Dalla, additional, Ceresa, M., additional, Colombo, E., additional, Pennisi, V., additional, Casciola, G., additional, Driussi, M., additional, Bisceglia, T., additional, Scalvini, S., additional, Rivadossi, F., additional, Volpe, M., additional, Comito, F., additional, Scorzoni, D., additional, Grimoldi, P., additional, Lagioia, R., additional, Santoro, D., additional, De Cesare, N., additional, Comotti, T., additional, Poli, A., additional, Martina, P., additional, Musolino, M.F., additional, Multari, E.I., additional, Bilardo, G., additional, Scalchi, G., additional, Olivieri, C., additional, Caranci, F., additional, Pavan, D., additional, Ganci, G., additional, Mariani, A., additional, Falchetti, E., additional, Lanzillo, T., additional, Caccavale, A., additional, Bongo, A.S., additional, Rizzi, A., additional, Favilli, R., additional, Maffei, S., additional, Mallardo, M., additional, Fulgione, C., additional, Bordin, F., additional, Bonmassari, R., additional, Battaia, E., additional, Puzzo, A., additional, Vianello, G., additional, D'Arpino, A., additional, Romei, M., additional, Pajes, G., additional, Petronzelli, S., additional, Ghezzi, F., additional, Brigido, S., additional, Pignatelli, L., additional, Brscic, E., additional, Sori, P., additional, Russo, M., additional, Biancolillo, E., additional, Ignone, G., additional, De Giorgio, N.A., additional, Campaniello, C., additional, Ponticelli, P., additional, Margonato, A., additional, Gerosa, S., additional, Cutaia, A., additional, Casalicchio, C., additional, Bartolomucci, F., additional, Larosa, C., additional, Spadafina, T., additional, Putignano, A., additional, De Cristofaro, R., additional, Bernardi, L., additional, Sommariva, L., additional, Celestini, A., additional, Bertucci, C.M., additional, Marchetti, M., additional, Grisolia, E Franceschini, additional, Ammendolea, C., additional, Carini, M., additional, Scipione, P., additional, Politano, M., additional, Rubino, G., additional, Reina, C., additional, Peccerillo, N., additional, Paloscia, L., additional, D'Alleva, A., additional, Petacchi, R., additional, Pignalosa, M., additional, Lucchetti, D., additional, Di Palma, F., additional, La Mastra, R.A., additional, Filippis, M De, additional, Fontanella, B., additional, Zanini, G., additional, Casolo, G., additional, Del Meglio, J., additional, Parato, V.M., additional, Genovesi, E., additional, D'Alimonte, A., additional, Miglioranza, A., additional, Alessandri, N., additional, Moscariello, F., additional, Mauro, C., additional, Sasso, A., additional, Caso, P., additional, Petrillo, C., additional, Napoletano, C., additional, Paparoni, S.R., additional, Bernardo, V., additional, Serdoz, R., additional, Rotunno, R., additional, Oppo, I., additional, Aloisio, A., additional, Aurelio, A., additional, Licciardello, G., additional, Cassaniti, L., additional, Francese, G.M., additional, Marcassa, C., additional, Villani, R., additional, Zorzoli, F., additional, Mileto, F., additional, Vecchis, M De, additional, Scolozzi, D., additional, Lupi, G., additional, Caruso, D., additional, Rebulla, E., additional, La Fata, B., additional, Anselmi, M., additional, Girardi, P., additional, Borruso, E., additional, Ferrantelli, G., additional, Sassone, B., additional, Bressan, S., additional, Capriolo, M., additional, Pelissero, E., additional, Piancastelli, M., additional, Gobbi, M., additional, Cocco, F., additional, Bruno, M.G., additional, Berti, S., additional, Lo Surdo, G., additional, Tanzi, P., additional, De Rosa, R., additional, Vilei, E., additional, De Iaco, M.R., additional, Grassi, G., additional, Zanella, C., additional, Marullo, L., additional, Alfano, G., additional, Pelaggi, P., additional, Talarico, R., additional, Tuccillo, B., additional, Irace, L., additional, Proietti, F., additional, Di Croce, G., additional, Di Lorenzo, L., additional, Zarrilli, A., additional, Bongini, M., additional, Ranise, A., additional, Aprile, A., additional, Fornengo, C., additional, Capogrosso, V., additional, Tranghese, A., additional, Golia, B., additional, Marziano, A., additional, Roncon, L., additional, Picariello, C., additional, Bagni, E., additional, Leci, E., additional, Gregorio, G., additional, Gatto, F., additional, Piemonte, F., additional, Gervasio, F., additional, Navazio, A., additional, Guerri, E., additional, Belmonte, E., additional, Marino, F., additional, Di Belardino, N., additional, Di Nuzzo, M.R., additional, Epifani, M., additional, Comolatti, G., additional, Conconi, B., additional, Benea, D., additional, Casu, G., additional, Merella, P., additional, Ammirati, M.A., additional, Corrado, V.M., additional, Spagnolo, D., additional, Caico, S.I., additional, Bonizzato, S., additional, Margheri, M., additional, Corrado, L., additional, Antonicelli, R., additional, Ferrigno, C., additional, Merlino, A., additional, Nassiacos, D., additional, Antonelli, A., additional, Marchese, A., additional, Uguccioni, M., additional, Villella, A., additional, Bechi, S., additional, Lo Bianco, F., additional, Bedogni, F., additional, Negro, L., additional, Donato, L., additional, Statile, D., additional, Cassin, M., additional, Fedele, F., additional, Granatelli, A., additional, Calcagno, S., additional, Politi, A., additional, and Pani., A., additional

Published
2023
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17. The triggerless data acquisition system of the XENONnT experiment

Author

Aprile, E., primary, Aalbers, J., additional, Abe, K., additional, Agostini, F., additional, Ahmed Maouloud, S., additional, Althueser, L., additional, Andrieu, B., additional, Angelino, E., additional, Angevaare, J.R., additional, Antochi, V.C., additional, Antón Martin, D., additional, Arneodo, F., additional, Baudis, L., additional, Baxter, A.L., additional, Bellagamba, L., additional, Biondi, R., additional, Bismark, A., additional, Brookes, E.J., additional, Brown, A., additional, Bruenner, S., additional, Bruno, G., additional, Budnik, R., additional, Bui, T.K., additional, Cai, C., additional, Cardoso, J.M.R., additional, Cichon, D., additional, Cimental Chavez, A.P., additional, Coderre, D., additional, Colijn, A.P., additional, Conrad, J., additional, Cuenca-García, J.J., additional, Cussonneau, J.P., additional, D'Andrea, V., additional, Decowski, M.P., additional, Di Gangi, P., additional, Di Pede, S., additional, Diglio, S., additional, Eitel, K., additional, Elykov, A., additional, Farrell, S., additional, Ferella, A.D., additional, Ferrari, C., additional, Fischer, H., additional, Flierman, M., additional, Fulgione, W., additional, Fuselli, C., additional, Gaemers, P., additional, Gaior, R., additional, Gallo Rosso, A., additional, Galloway, M., additional, Gao, F., additional, Glade-Beucke, R., additional, Grandi, L., additional, Grigat, J., additional, Guida, M., additional, Hammann, R., additional, Higuera, A., additional, Hils, C., additional, Hoetzsch, L., additional, Hood, N.F., additional, Howlett, J., additional, Iacovacci, M., additional, Itow, Y., additional, Jakob, J., additional, Joerg, F., additional, Joy, A., additional, Kato, N., additional, Kara, M., additional, Kavrigin, P., additional, Kazama, S., additional, Kobayashi, M., additional, Koltman, G., additional, Kopec, A., additional, Kuger, F., additional, Landsman, H., additional, Lang, R.F., additional, Levinson, L., additional, Li, I., additional, Li, S., additional, Liang, S., additional, Lindemann, S., additional, Lindner, M., additional, Liu, K., additional, Loizeau, J., additional, Lombardi, F., additional, Long, J., additional, Lopes, J.A.M., additional, Ma, Y., additional, Macolino, C., additional, Mahlstedt, J., additional, Mancuso, A., additional, Manenti, L., additional, Marignetti, F., additional, Marrodán Undagoitia, T., additional, Martens, K., additional, Masbou, J., additional, Masson, D., additional, Masson, E., additional, Mastroianni, S., additional, Messina, M., additional, Miuchi, K., additional, Mizukoshi, K., additional, Molinario, A., additional, Moriyama, S., additional, Morå, K., additional, Mosbacher, Y., additional, Murra, M., additional, Müller, J., additional, Ni, K., additional, Oberlack, U., additional, Paetsch, B., additional, Palacio, J., additional, Peres, R., additional, Peters, C., additional, Pienaar, J., additional, Pierre, M., additional, Pizzella, V., additional, Plante, G., additional, Qi, J., additional, Qin, J., additional, Ramírez García, D., additional, Rocchetti, A., additional, Sanchez, L., additional, Sanchez-Lucas, P., additional, dos Santos, J.M.F., additional, Sarnoff, I., additional, Sartorelli, G., additional, Schreiner, J., additional, Schulte, D., additional, Schulte, P., additional, Schulze Eißing, H., additional, Schumann, M., additional, Scotto Lavina, L., additional, Selvi, M., additional, Semeria, F., additional, Shagin, P., additional, Shi, S., additional, Shockley, E., additional, Silva, M., additional, Simgen, H., additional, Takeda, A., additional, Tan, P.-L., additional, Terliuk, A., additional, Thers, D., additional, Toschi, F., additional, Trinchero, G., additional, Tunnell, C., additional, Tönnies, F., additional, Valerius, K., additional, Volta, G., additional, Weinheimer, C., additional, Weiss, M., additional, Wenz, D., additional, Wittweg, C., additional, Wolf, T., additional, Xu, D., additional, Xu, Z., additional, Yamashita, M., additional, Yang, L., additional, Ye, J., additional, Yuan, L., additional, Zavattini, G., additional, Zerbo, S., additional, Zhong, M., additional, and Zhu, T., additional

Published
2023
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18. Low-energy calibration of XENON1T with an internal $$^{{\textbf {37}}}$$ <math> <msup> <mrow></mrow> <mn>37</mn> </msup> </math> Ar source

Author

Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J., Antochi, V., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T., Cai, C., Capelli, C., Cardoso, J., Cichon, D., Colijn, A., Conrad, J., Cuenca-García, J., Cussonneau, J., D’Andrea, V., Decowski, M., Gangi, P., Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Sanchez-Lucas, P., Santos, J., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P.L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., Zhu, T., Geppert, C., and Riemer, J.

Abstract

A low-energy electronic recoil calibration of XENON1T, a dual-phase xenon time projection chamber, with an internal $${}^{37}$$ 37 Ar source was performed. This calibration source features a 35-day half-life and provides two mono-energetic lines at 2.82 keV and 0.27 keV. The photon yield and electron yield at 2.82 keV are measured to be ( $$32.3\,\pm \,0.3$$ 32.3 ± 0.3 ) photons/keV and ( $$40.6\,\pm \,0.5$$ 40.6 ± 0.5 ) electrons/keV, respectively, in agreement with other measurements and with NEST predictions. The electron yield at 0.27 keV is also measured and it is ( $$68.0^{+6.3}_{-3.7}$$ 68 . 0 - 3.7 + 6.3 ) electrons/keV. The $${}^{37}$$ 37 Ar calibration confirms that the detector is well-understood in the energy region close to the detection threshold, with the 2.82 keV line reconstructed at ( $$2.83\,\pm \,0.02$$ 2.83 ± 0.02 ) keV, which further validates the model used to interpret the low-energy electronic recoil excess previously reported by XENON1T. The ability to efficiently remove argon with cryogenic distillation after the calibration proves that $${}^{37}$$ 37 Ar can be considered as a regular calibration source for multi-tonne xenon detectors.

Published
2023

19. A next-generation liquid xenon observatory for dark matter and neutrino physics

Author

Aalbers, J, AbdusSalam, S S, Abe, K, Aerne, V, Agostini, F, Ahmed Maouloud, S, Akerib, D S, Akimov, D Y, Akshat, J, Al Musalhi, A K, Alder, F, Alsum, S K, Althueser, L, Amarasinghe, C S, Amaro, F D, Ames, A, Anderson, T J, Andrieu, B, Angelides, N, Angelino, E, Angevaare, J, Antochi, V C, Antón Martin, D, Antunovic, B, Aprile, E, Araújo, H M, Armstrong, J E, Arneodo, F, Arthurs, M, Asadi, P, Baek, S, Bai, X, Bajpai, D, Baker, A, Balajthy, J, Balashov, S, Balzer, M, Bandyopadhyay, A, Bang, J, Barberio, E, Bargemann, J W, Baudis, L, Bauer, D, Baur, D, Baxter, A, Baxter, A L, Bazyk, M, Beattie, K, Behrens, J, Bell, N F, Bellagamba, L, Beltrame, P, Benabderrahmane, M, Bernard, E P, Bertone, G F, Bhattacharjee, P, Bhatti, A, Biekert, A, Biesiadzinski, T P, Binau, A R, Biondi, R, Biondi, Y, Birch, H J, Bishara, F, Bismark, A, Blanco, C, Blockinger, G M, Bodnia, E, Boehm, C, Bolozdynya, A I, Bolton, P D, Bottaro, S, Bourgeois, C, Boxer, B, Brás, P, Breskin, A, Breur, P A, Brew, C A J, Brod, J, Brookes, E, Brown, A, Brown, E, Bruenner, S, Bruno, G, Budnik, R, Bui, T K, Burdin, S, Buse, S, Busenitz, J K, Buttazzo, D, Buuck, M, Buzulutskov, A, Cabrita, R, Cai, C, Cai, D, Capelli, C, Cardoso, J M R, Carmona-Benitez, M C, Cascella, M, Catena, R, Chakraborty, S, Chan, C, Chang, S, Chauvin, A, Chawla, A, Chen, H, Chepel, V, Chott, N I, Cichon, D, Cimental Chavez, A, Cimmino, B, Clark, M, Co, R T, Colijn, A P, Conrad, J, Converse, M V, Costa, M, Cottle, A, Cox, G, Creaner, O, Cuenca Garcia, J J, Cussonneau, J P, Cutter, J E, Dahl, C E, D’Andrea, V, David, A, Decowski, M P, Dent, J B, Deppisch, F F, de Viveiros, L, Di Gangi, P, Di Giovanni, A, Di Pede, S, Dierle, J, Diglio, S, Dobson, J E Y, Doerenkamp, M, Douillet, D, Drexlin, G, Druszkiewicz, E, Dunsky, D, Eitel, K, Elykov, A, Emken, T, Engel, R, Eriksen, S R, Fairbairn, M, Fan, A, Fan, J J, Farrell, S J, Fayer, S, Fearon, N M, Ferella, A, Ferrari, C, Fieguth, A, Fiorucci, S, Fischer, H, Flaecher, H, Flierman, M, Florek, T, Foot, R, Fox, P J, Franceschini, R, Fraser, E D, Frenk, C S, Frohlich, S, Fruth, T, Fulgione, W, Fuselli, C, Gaemers, P, Gaior, R, Gaitskell, R J, Galloway, M, Gao, F, Garcia Garcia, I, Genovesi, J, Ghag, C, Ghosh, S, Gibson, E, Gil, W, Giovagnoli, D, Girard, F, Glade-Beucke, R, Glück, F, Gokhale, S, de Gouvêa, A, Gráf, L, Grandi, L, Grigat, J, Grinstein, B, van der Grinten, M G D, Grössle, R, Guan, H, Guida, M, Gumbsheimer, R, Gwilliam, C B, Hall, C R, Hall, L J, Hammann, R, Han, K, Hannen, V, Hansmann-Menzemer, S, Harata, R, Hardin, S P, Hardy, E, Hardy, C A, Harigaya, K, Harnik, R, Haselschwardt, S J, Hernandez, M, Hertel, S A, Higuera, A, Hils, C, Hochrein, S, Hoetzsch, L, Hoferichter, M, Hood, N, Hooper, D, Horn, M, Howlett, J, Huang, D Q, Huang, Y, Hunt, D, Iacovacci, M, Iaquaniello, G, Ide, R, Ignarra, C M, Iloglu, G, Itow, Y, Jacquet, E, Jahangir, O, Jakob, J, James, R S, Jansen, A, Ji, W, Ji, X, Joerg, F, Johnson, J, Joy, A, Kaboth, A C, Kalhor, L, Kamaha, A C, Kanezaki, K, Kar, K, Kara, M, Kato, N, Kavrigin, P, Kazama, S, Keaveney, A W, Kellerer, J, Khaitan, D, Khazov, A, Khundzakishvili, G, Khurana, I, Kilminster, B, Kleifges, M, Ko, P, Kobayashi, M, Kodroff, D, Koltmann, G, Kopec, A, Kopmann, A, Kopp, J, Korley, L, Kornoukhov, V N, Korolkova, E V, Kraus, H, Krauss, L M, Kravitz, S, Kreczko, L, Kudryavtsev, V A, Kuger, F, Kumar, J, López Paredes, B, LaCascio, L, Laha, R, Laine, Q, Landsman, H, Lang, R F, Leason, E A, Lee, J, Leonard, D S, Lesko, K T, Levinson, L, Levy, C, Li, I, Li, S C, Li, T, Liang, S, Liebenthal, C S, Lin, J, Lin, Q, Lindemann, S, Lindner, M, Lindote, A, Linehan, R, Lippincott, W H, Liu, X, Liu, K, Liu, J, Loizeau, J, Lombardi, F, Long, J, Lopes, M I, Lopez Asamar, E, Lorenzon, W, Lu, C, Luitz, S, Ma, Y, Machado, P A N, Macolino, C, Maeda, T, Mahlstedt, J, Majewski, P A, Manalaysay, A, Mancuso, A, Manenti, L, Manfredini, A, Mannino, R L, Marangou, N, March-Russell, J, Marignetti, F, Marrodán Undagoitia, T, Martens, K, Martin, R, 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Lippincott, W H, Liu, X, Liu, K, Liu, J, Loizeau, J, Lombardi, F, Long, J, Lopes, M I, Lopez Asamar, E, Lorenzon, W, Lu, C, Luitz, S, Ma, Y, Machado, P A N, Macolino, C, Maeda, T, Mahlstedt, J, Majewski, P A, Manalaysay, A, Mancuso, A, Manenti, L, Manfredini, A, Mannino, R L, Marangou, N, March-Russell, J, Marignetti, F, Marrodán Undagoitia, T, Martens, K, Martin, R, Martinez-Soler, I, Masbou, J, Masson, D, Masson, E, Mastroianni, S, Mastronardi, M, Matias-Lopes, J A, McCarthy, M E, McFadden, N, McGinness, E, McKinsey, D N, McLaughlin, J, McMichael, K, Meinhardt, P, Menéndez, J, Meng, Y, Messina, M, Midha, R, Milisavljevic, D, Miller, E H, Milosevic, B, Milutinovic, S, Mitra, S A, Miuchi, K, Mizrachi, E, Mizukoshi, K, Molinario, A, Monte, A, Monteiro, C M B, Monzani, M E, Moore, J S, Morå, K, Morad, J A, Morales Mendoza, J D, Moriyama, S, Morrison, E, Morteau, E, Mosbacher, Y, Mount, B J, Mueller, J, Murphy, A St J, Murra, M, Naim, D, Nakamura, S, Nash, E, Navaieelavasani, N, Naylor, A, Nedlik, C, Nelson, H N, Neves, F, Newstead, J L, Ni, K, Nikoleyczik, J A, Niro, V, Oberlack, U G, Obradovic, M, Odgers, K, O’Hare, C A J, Oikonomou, P, Olcina, I, Oliver-Mallory, K, Oranday, A, Orpwood, J, Ostrovskiy, I, Ozaki, K, Paetsch, B, Pal, S, Palacio, J, Palladino, K J, Palmer, J, Panci, P, Pandurovic, M, Parlati, A, Parveen, N, Patton, S J, Pěč, V, Pellegrini, Q, Penning, B, Pereira, G, Peres, R, Perez-Gonzalez, Y, Perry, E, Pershing, T, Petrossian-Byrne, R, Pienaar, J, Piepke, A, Pieramico, G, Pierre, M, Piotter, M, Pizzella, V, Plante, G, Pollmann, T, Porzio, D, Qi, J, Qie, Y, Qin, J, Quevedo, F, Raj, N, Rajado Silva, M, Ramanathan, K, Ramírez García, D, Ravanis, J, Redard-Jacot, L, Redigolo, D, Reichard, S, Reichenbacher, J, Rhyne, C A, Richards, A, Riffard, Q, Rischbieter, G R C, Rocchetti, A, Rosenfeld, S L, Rosero, R, Rupp, N, Rushton, T, Saha, S, Salucci, P, Sanchez, L, Sanchez-Lucas, P, Santone, D, dos Santos, J M F, Sarnoff, I, Sartorelli, G, Sazzad, A B M R, Scheibelhut, M, Schnee, R W, Schrank, M, Schreiner, J, Schulte, P, Schulte, D, Schulze Eissing, H, Schumann, M, Schwemberger, T, Schwenk, A, Schwetz, T, Scotto Lavina, L, Scovell, P R, Sekiya, H, Selvi, M, Semenov, E, Semeria, F, Shagin, P, Shaw, S, Shi, S, Shockley, E, Shutt, T A, Si-Ahmed, R, Silk, J J, Silva, C, Silva, M C, Simgen, H, Šimkovic, F, Sinev, G, Singh, R, Skulski, W, Smirnov, J, Smith, R, Solmaz, M, Solovov, V N, Sorensen, P, Soria, J, Sparmann, T J, Stancu, I, Steidl, M, Stevens, A, Stifter, K, Strigari, L E, Subotic, D, Suerfu, B, Suliga, A M, Sumner, T J, Szabo, P, Szydagis, M, Takeda, A, Takeuchi, Y, Tan, P-L, Taricco, C, Taylor, W C, Temples, D J, Terliuk, A, Terman, P A, Thers, D, Thieme, K, Thümmler, T, Tiedt, D R, Timalsina, M, To, W H, Toennies, F, Tong, Z, Toschi, F, Tovey, D R, Tranter, J, Trask, M, Trinchero, G C, Tripathi, M, Tronstad, D R, Trotta, R, Tsai, Y D, Tunnell, C D, Turner, W G, Ueno, R, Urquijo, P, Utku, U, Vaitkus, A, Valerius, K, Vassilev, E, Vecchi, S, Velan, V, Vetter, S, Vincent, A C, Vittorio, L, Volta, G, von Krosigk, B, von Piechowski, M, Vorkapic, D, Wagner, C E M, Wang, A M, Wang, B, Wang, Y, Wang, W, Wang, J J, Wang, L-T, Wang, M, Watson, J R, Wei, Y, Weinheimer, C, Weisman, E, Weiss, M, Wenz, D, West, S M, Whitis, T J, Williams, M, Wilson, M J, Winkler, D, Wittweg, C, Wolf, J, Wolf, T, Wolfs, F L H, Woodford, S, Woodward, D, Wright, C J, Wu, V H S, Wu, P, Wüstling, S, Wurm, M, Xia, Q, Xiang, X, Xing, Y, Xu, J, Xu, Z, Xu, D, Yamashita, M, Yamazaki, R, Yan, H, Yang, L, Yang, Y, Ye, J, Yeh, M, Young, I, Yu, H B, Yu, T T, Yuan, L, Zavattini, G, Zerbo, S, Zhang, Y, Zhong, M, Zhou, N, Zhou, X, Zhu, T, Zhu, Y, Zhuang, Y, Zopounidis, J P, Zuber, K, and Zupan, J

Abstract

The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon time-projection chamber is the leading technology to cover the available parameter space for weakly interacting massive particles, while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinoless double-beta decay and through a variety of astrophysical sources. A next-generation xenon-based detector will therefore be a true multi-purpose observatory to significantly advance particle physics, nuclear physics, astrophysics, solar physics, and cosmology. This review article presents the science cases for such a detector.

Published
2023

20. Search for New Physics in Electronic Recoil Data from XENONnT

Author

XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D’Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Gardner, R., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Paschos, P., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Stephen, J., Takeda, A., Tan, P.-L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., Zhu, T., IoP (FNWI), XENON (IHEF, IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), Aprile, E, Abe, K, Agostini, F, Ahmed Maouloud, S, Althueser, L, Andrieu, B, Angelino, E, Angevaare, J R, Antochi, V C, Antón Martin, D, Arneodo, F, Baudis, L, Baxter, A L, Bellagamba, L, Biondi, R, Bismark, A, Brown, A, Bruenner, S, Bruno, G, Budnik, R, Bui, T K, Cai, C, Capelli, C, Cardoso, J M R, Cichon, D, Clark, M, Colijn, A P, Conrad, J, Cuenca-García, J J, Cussonneau, J P, D'Andrea, V, Decowski, M P, Di Gangi, P, Di Pede, S, Di Giovanni, A, Di Stefano, R, Diglio, S, Eitel, K, Elykov, A, Farrell, S, Ferella, A D, Ferrari, C, Fischer, H, Fulgione, W, Gaemers, P, Gaior, R, Gallo Rosso, A, Galloway, M, Gao, F, Gardner, R, Glade-Beucke, R, Grandi, L, Grigat, J, Guida, M, Hammann, R, Higuera, A, Hils, C, Hoetzsch, L, Howlett, J, Iacovacci, M, Itow, Y, Jakob, J, Joerg, F, Joy, A, Kato, N, Kara, M, Kavrigin, P, Kazama, S, Kobayashi, M, Koltman, G, Kopec, A, Kuger, F, Landsman, H, Lang, R F, Levinson, L, Li, I, Li, S, Liang, S, Lindemann, S, Lindner, M, Liu, K, Loizeau, J, Lombardi, F, Long, J, Lopes, J A M, Ma, Y, Macolino, C, Mahlstedt, J, Mancuso, A, Manenti, L, Marignetti, F, Marrodán Undagoitia, T, Martens, K, Masbou, J, Masson, D, Masson, E, Mastroianni, S, Messina, M, Miuchi, K, Mizukoshi, K, Molinario, A, Moriyama, S, Morå, K, Mosbacher, Y, Murra, M, Müller, J, Ni, K, Oberlack, U, Paetsch, B, Palacio, J, Paschos, P, Peres, R, Peters, C, Pienaar, J, Pierre, M, Pizzella, V, Plante, G, Qi, J, Qin, J, Ramírez García, D, Reichard, S, Rocchetti, A, Rupp, N, Sanchez, L, Dos Santos, J M F, Sarnoff, I, Sartorelli, G, Schreiner, J, Schulte, D, Schulte, P, Schulze Eißing, H, Schumann, M, Scotto Lavina, L, Selvi, M, Semeria, F, Shagin, P, Shi, S, Shockley, E, Silva, M, Simgen, H, Stephen, J, Takeda, A, Tan, P-L, Terliuk, A, Thers, D, Toschi, F, Trinchero, G, Tunnell, C, Tönnies, F, Valerius, K, Volta, G, Wei, Y, Weinheimer, C, Weiss, M, Wenz, D, Wittweg, C, Wolf, T, Xu, D, Xu, Z, Yamashita, M, Yang, L, Ye, J, Yuan, L, Zavattini, G, Zhong, M, Zhu, T, and HEP, INSPIRE

Subjects
xenon: target, neutrino: solar, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], WIMP, electronic recoil, General Physics and Astronomy, FOS: Physical sciences, coupling constant: upper limit, dark matter: direct detection, WIMP: dark matter, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), recoil, Dark Matter, ddc:530, coupling: (axion 2electron), Xenon nT, xenon: liquid, photon: hidden sector, boson: dark matter, axion: dark matter, background, new physics: search for, Physics, dark matter: detector, neutrino: magnetic moment, Xenon nT, Dark Matter, WIMP, electronic recoil, coupling: (axion 2photon), axion: solar, experimental results
Abstract

We report on a blinded analysis of low-energy electronic-recoil data from the first science run of the XENONnT dark matter experiment. Novel subsystems and the increased 5.9 tonne liquid xenon target reduced the background in the (1, 30) keV search region to $(15.8 \pm 1.3)$ events/(tonne$\times$year$\times$keV), the lowest ever achieved in a dark matter detector and $\sim$5 times lower than in XENON1T. With an exposure of 1.16 tonne-years, we observe no excess above background and set stringent new limits on solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter., Comment: 10 pages, 6 figures. Data points are available in https://zenodo.org/record/7311940

Published
2022

21. Searching for Heavy Dark Matter near the Planck Mass with XENON1T

Author

XENON Collaboration, Aprile, E., Abe, K., Ahmed Maouloud, S., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Cimental Chavez, A. P., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D’Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Pollmann, T. R., Qi, J., Qin, J., Ramírez García, D., Singh, R., Sanchez, L., dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P.-L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
Physics, ddc:530
Abstract

Multiple viable theoretical models predict heavy dark matter particles with a mass close to the Planck mass, a range relatively unexplored by current experimental measurements. We use 219.4 days of data collected with the XENON1T experiment to conduct a blind search for signals from multiply interacting massive particles (MIMPs). Their unique track signature allows a targeted analysis with only 0.05 expected background events from muons. Following unblinding, we observe no signal candidate events. This Letter places strong constraints on spin-independent interactions of dark matter particles with a mass between 1×10$^{12}$ and 2×10$^{17}$ GeV/c$^2$. In addition, we present the first exclusion limits on spin-dependent MIMP-neutron and MIMP-proton cross sections for dark matter particles with masses close to the Planck scale.

Published
2023
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22. Low-energy calibration of XENON1T with an internal $^{{\textbf {37}}}$Ar source

Author

XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D’Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Sanchez-Lucas, P., Santos, J. M. F. Dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P.-L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., Zhu, T., Geppert, C., and Riemer, J.

Subjects
Physics, ddc:530
Abstract

A low-energy electronic recoil calibration of XENON1T, a dual-phase xenon time projection chamber, with an internal 37Ar source was performed. This calibration source features a 35-day half-life and provides two mono-energetic lines at 2.82 keV and 0.27 keV. The photon yield and electron yield at 2.82 keV are measured to be (32.3±0.3) photons/keV and (40.6±0.5) electrons/keV, respectively, in agreement with other measurements and with NEST predictions. The electron yield at 0.27 keV is also measured and it is (68.0+6.3−3.7) electrons/keV. The 37Ar calibration confirms that the detector is well-understood in the energy region close to the detection threshold, with the 2.82 keV line reconstructed at (2.83±0.02) keV, which further validates the model used to interpret the low-energy electronic recoil excess previously reported by XENON1T. The ability to efficiently remove argon with cryogenic distillation after the calibration proves that 37Ar can be considered as a regular calibration source for multi-tonne xenon detectors.

Published
2023

23. A next-generation liquid xenon observatory for dark matter and neutrino physics

Author

Aalbers, J, primary, AbdusSalam, S S, additional, Abe, K, additional, Aerne, V, additional, Agostini, F, additional, Ahmed Maouloud, S, additional, Akerib, D S, additional, Akimov, D Y, additional, Akshat, J, additional, Al Musalhi, A K, additional, Alder, F, additional, Alsum, S K, additional, Althueser, L, additional, Amarasinghe, C S, additional, Amaro, F D, additional, Ames, A, additional, Anderson, T J, additional, Andrieu, B, additional, Angelides, N, additional, Angelino, E, additional, Angevaare, J, additional, Antochi, V C, additional, Antón Martin, D, additional, Antunovic, B, additional, Aprile, E, additional, Araújo, H M, additional, Armstrong, J E, additional, Arneodo, F, additional, Arthurs, M, additional, Asadi, P, additional, Baek, S, additional, Bai, X, additional, Bajpai, D, additional, Baker, A, additional, Balajthy, J, additional, Balashov, S, additional, Balzer, M, additional, Bandyopadhyay, A, additional, Bang, J, additional, Barberio, E, additional, Bargemann, J W, additional, Baudis, L, additional, Bauer, D, additional, Baur, D, additional, Baxter, A, additional, Baxter, A L, additional, Bazyk, M, additional, Beattie, K, additional, Behrens, J, additional, Bell, N F, additional, Bellagamba, L, additional, Beltrame, P, additional, Benabderrahmane, M, additional, Bernard, E P, additional, Bertone, G F, additional, Bhattacharjee, P, additional, Bhatti, A, additional, Biekert, A, additional, Biesiadzinski, T P, additional, Binau, A R, additional, Biondi, R, additional, Biondi, Y, additional, Birch, H J, additional, Bishara, F, additional, Bismark, A, additional, Blanco, C, additional, Blockinger, G M, additional, Bodnia, E, additional, Boehm, C, additional, Bolozdynya, A I, additional, Bolton, P D, additional, Bottaro, S, additional, Bourgeois, C, additional, Boxer, B, additional, Brás, P, additional, Breskin, A, additional, Breur, P A, additional, Brew, C A J, additional, Brod, J, additional, Brookes, E, additional, Brown, A, additional, Brown, E, additional, Bruenner, S, additional, Bruno, G, additional, Budnik, R, additional, Bui, T K, additional, Burdin, S, additional, Buse, S, additional, Busenitz, J K, additional, Buttazzo, D, additional, Buuck, M, additional, Buzulutskov, A, additional, Cabrita, R, additional, Cai, C, additional, Cai, D, additional, Capelli, C, additional, Cardoso, J M R, additional, Carmona-Benitez, M C, additional, Cascella, M, additional, Catena, R, additional, Chakraborty, S, additional, Chan, C, additional, Chang, S, additional, Chauvin, A, additional, Chawla, A, additional, Chen, H, additional, Chepel, V, additional, Chott, N I, additional, Cichon, D, additional, Cimental Chavez, A, additional, Cimmino, B, additional, Clark, M, additional, Co, R T, additional, Colijn, A P, additional, Conrad, J, additional, Converse, M V, additional, Costa, M, additional, Cottle, A, additional, Cox, G, additional, Creaner, O, additional, Cuenca Garcia, J J, additional, Cussonneau, J P, additional, Cutter, J E, additional, Dahl, C E, additional, D’Andrea, V, additional, David, A, additional, Decowski, M P, additional, Dent, J B, additional, Deppisch, F F, additional, de Viveiros, L, additional, Di Gangi, P, additional, Di Giovanni, A, additional, Di Pede, S, additional, Dierle, J, additional, Diglio, S, additional, Dobson, J E Y, additional, Doerenkamp, M, additional, Douillet, D, additional, Drexlin, G, additional, Druszkiewicz, E, additional, Dunsky, D, additional, Eitel, K, additional, Elykov, A, additional, Emken, T, additional, Engel, R, additional, Eriksen, S R, additional, Fairbairn, M, additional, Fan, A, additional, Fan, J J, additional, Farrell, S J, additional, Fayer, S, additional, Fearon, N M, additional, Ferella, A, additional, Ferrari, C, additional, Fieguth, A, additional, Fiorucci, S, additional, Fischer, H, additional, Flaecher, H, additional, Flierman, M, additional, Florek, T, additional, Foot, R, additional, Fox, P J, additional, Franceschini, R, additional, Fraser, E D, additional, Frenk, C S, additional, Frohlich, S, additional, Fruth, T, additional, Fulgione, W, additional, Fuselli, C, additional, Gaemers, P, additional, Gaior, R, additional, Gaitskell, R J, additional, Galloway, M, additional, Gao, F, additional, Garcia Garcia, I, additional, Genovesi, J, additional, Ghag, C, additional, Ghosh, S, additional, Gibson, E, additional, Gil, W, additional, Giovagnoli, D, additional, Girard, F, additional, Glade-Beucke, R, additional, Glück, F, additional, Gokhale, S, additional, de Gouvêa, A, additional, Gráf, L, additional, Grandi, L, additional, Grigat, J, additional, Grinstein, B, additional, van der Grinten, M G D, additional, Grössle, R, additional, Guan, H, additional, Guida, M, additional, Gumbsheimer, R, additional, Gwilliam, C B, additional, Hall, C R, additional, Hall, L J, additional, Hammann, R, additional, Han, K, additional, Hannen, V, additional, Hansmann-Menzemer, S, additional, Harata, R, additional, Hardin, S P, additional, Hardy, E, additional, Hardy, C A, additional, Harigaya, K, additional, Harnik, R, additional, Haselschwardt, S J, additional, Hernandez, M, additional, Hertel, S A, additional, Higuera, A, additional, Hils, C, additional, Hochrein, S, additional, Hoetzsch, L, additional, Hoferichter, M, additional, Hood, N, additional, Hooper, D, additional, Horn, M, additional, Howlett, J, additional, Huang, D Q, additional, Huang, Y, additional, Hunt, D, additional, Iacovacci, M, additional, Iaquaniello, G, additional, Ide, R, additional, Ignarra, C M, additional, Iloglu, G, additional, Itow, Y, additional, Jacquet, E, additional, Jahangir, O, additional, Jakob, J, additional, James, R S, additional, Jansen, A, additional, Ji, W, additional, Ji, X, additional, Joerg, F, additional, Johnson, J, additional, Joy, A, additional, Kaboth, A C, additional, Kalhor, L, additional, Kamaha, A C, additional, Kanezaki, K, additional, Kar, K, additional, Kara, M, additional, Kato, N, additional, Kavrigin, P, additional, Kazama, S, additional, Keaveney, A W, additional, Kellerer, J, additional, Khaitan, D, additional, Khazov, A, additional, Khundzakishvili, G, additional, Khurana, I, additional, Kilminster, B, additional, Kleifges, M, additional, Ko, P, additional, Kobayashi, M, additional, Kodroff, D, additional, Koltmann, G, additional, Kopec, A, additional, Kopmann, A, additional, Kopp, J, additional, Korley, L, additional, Kornoukhov, V N, additional, Korolkova, E V, additional, Kraus, H, additional, Krauss, L M, additional, Kravitz, S, additional, Kreczko, L, additional, Kudryavtsev, V A, additional, Kuger, F, additional, Kumar, J, additional, López Paredes, B, additional, LaCascio, L, additional, Laha, R, additional, Laine, Q, additional, Landsman, H, additional, Lang, R F, additional, Leason, E A, additional, Lee, J, additional, Leonard, D S, additional, Lesko, K T, additional, Levinson, L, additional, Levy, C, additional, Li, I, additional, Li, S C, additional, Li, T, additional, Liang, S, additional, Liebenthal, C S, additional, Lin, J, additional, Lin, Q, additional, Lindemann, S, additional, Lindner, M, additional, Lindote, A, additional, Linehan, R, additional, Lippincott, W H, additional, Liu, X, additional, Liu, K, additional, Liu, J, additional, Loizeau, J, additional, Lombardi, F, additional, Long, J, additional, Lopes, M I, additional, Lopez Asamar, E, additional, Lorenzon, W, additional, Lu, C, additional, Luitz, S, additional, Ma, Y, additional, Machado, P A N, additional, Macolino, C, additional, Maeda, T, additional, Mahlstedt, J, additional, Majewski, P A, additional, Manalaysay, A, additional, Mancuso, A, additional, Manenti, L, additional, Manfredini, A, additional, Mannino, R L, additional, Marangou, N, additional, March-Russell, J, additional, Marignetti, F, additional, Marrodán Undagoitia, T, additional, Martens, K, additional, Martin, R, additional, Martinez-Soler, I, additional, Masbou, J, additional, Masson, D, additional, Masson, E, additional, Mastroianni, S, additional, Mastronardi, M, additional, Matias-Lopes, J A, additional, McCarthy, M E, additional, McFadden, N, additional, McGinness, E, additional, McKinsey, D N, additional, McLaughlin, J, additional, McMichael, K, additional, Meinhardt, P, additional, Menéndez, J, additional, Meng, Y, additional, Messina, M, additional, Midha, R, additional, Milisavljevic, D, additional, Miller, E H, additional, Milosevic, B, additional, Milutinovic, S, additional, Mitra, S A, additional, Miuchi, K, additional, Mizrachi, E, additional, Mizukoshi, K, additional, Molinario, A, additional, Monte, A, additional, Monteiro, C M B, additional, Monzani, M E, additional, Moore, J S, additional, Morå, K, additional, Morad, J A, additional, Morales Mendoza, J D, additional, Moriyama, S, additional, Morrison, E, additional, Morteau, E, additional, Mosbacher, Y, additional, Mount, B J, additional, Mueller, J, additional, Murphy, A St J, additional, Murra, M, additional, Naim, D, additional, Nakamura, S, additional, Nash, E, additional, Navaieelavasani, N, additional, Naylor, A, additional, Nedlik, C, additional, Nelson, H N, additional, Neves, F, additional, Newstead, J L, additional, Ni, K, additional, Nikoleyczik, J A, additional, Niro, V, additional, Oberlack, U G, additional, Obradovic, M, additional, Odgers, K, additional, O’Hare, C A J, additional, Oikonomou, P, additional, Olcina, I, additional, Oliver-Mallory, K, additional, Oranday, A, additional, Orpwood, J, additional, Ostrovskiy, I, additional, Ozaki, K, additional, Paetsch, B, additional, Pal, S, additional, Palacio, J, additional, Palladino, K J, additional, Palmer, J, additional, Panci, P, additional, Pandurovic, M, additional, Parlati, A, additional, Parveen, N, additional, Patton, S J, additional, Pěč, V, additional, Pellegrini, Q, additional, Penning, B, additional, Pereira, G, additional, Peres, R, additional, Perez-Gonzalez, Y, additional, Perry, E, additional, Pershing, T, additional, Petrossian-Byrne, R, additional, Pienaar, J, additional, Piepke, A, additional, Pieramico, G, additional, Pierre, M, additional, Piotter, M, additional, Pizzella, V, additional, Plante, G, additional, Pollmann, T, additional, Porzio, D, additional, Qi, J, additional, Qie, Y, additional, Qin, J, additional, Quevedo, F, additional, Raj, N, additional, Rajado Silva, M, additional, Ramanathan, K, additional, Ramírez García, D, additional, Ravanis, J, additional, Redard-Jacot, L, additional, Redigolo, D, additional, Reichard, S, additional, Reichenbacher, J, additional, Rhyne, C A, additional, Richards, A, additional, Riffard, Q, additional, Rischbieter, G R C, additional, Rocchetti, A, additional, Rosenfeld, S L, additional, Rosero, R, additional, Rupp, N, additional, Rushton, T, additional, Saha, S, additional, Salucci, P, additional, Sanchez, L, additional, Sanchez-Lucas, P, additional, Santone, D, additional, dos Santos, J M F, additional, Sarnoff, I, additional, Sartorelli, G, additional, Sazzad, A B M R, additional, Scheibelhut, M, additional, Schnee, R W, additional, Schrank, M, additional, Schreiner, J, additional, Schulte, P, additional, Schulte, D, additional, Schulze Eissing, H, additional, Schumann, M, additional, Schwemberger, T, additional, Schwenk, A, additional, Schwetz, T, additional, Scotto Lavina, L, additional, Scovell, P R, additional, Sekiya, H, additional, Selvi, M, additional, Semenov, E, additional, Semeria, F, additional, Shagin, P, additional, Shaw, S, additional, Shi, S, additional, Shockley, E, additional, Shutt, T A, additional, Si-Ahmed, R, additional, Silk, J J, additional, Silva, C, additional, Silva, M C, additional, Simgen, H, additional, Šimkovic, F, additional, Sinev, G, additional, Singh, R, additional, Skulski, W, additional, Smirnov, J, additional, Smith, R, additional, Solmaz, M, additional, Solovov, V N, additional, Sorensen, P, additional, Soria, J, additional, Sparmann, T J, additional, Stancu, I, additional, Steidl, M, additional, Stevens, A, additional, Stifter, K, additional, Strigari, L E, additional, Subotic, D, additional, Suerfu, B, additional, Suliga, A M, additional, Sumner, T J, additional, Szabo, P, additional, Szydagis, M, additional, Takeda, A, additional, Takeuchi, Y, additional, Tan, P-L, additional, Taricco, C, additional, Taylor, W C, additional, Temples, D J, additional, Terliuk, A, additional, Terman, P A, additional, Thers, D, additional, Thieme, K, additional, Thümmler, T, additional, Tiedt, D R, additional, Timalsina, M, additional, To, W H, additional, Toennies, F, additional, Tong, Z, additional, Toschi, F, additional, Tovey, D R, additional, Tranter, J, additional, Trask, M, additional, Trinchero, G C, additional, Tripathi, M, additional, Tronstad, D R, additional, Trotta, R, additional, Tsai, Y D, additional, Tunnell, C D, additional, Turner, W G, additional, Ueno, R, additional, Urquijo, P, additional, Utku, U, additional, Vaitkus, A, additional, Valerius, K, additional, Vassilev, E, additional, Vecchi, S, additional, Velan, V, additional, Vetter, S, additional, Vincent, A C, additional, Vittorio, L, additional, Volta, G, additional, von Krosigk, B, additional, von Piechowski, M, additional, Vorkapic, D, additional, Wagner, C E M, additional, Wang, A M, additional, Wang, B, additional, Wang, Y, additional, Wang, W, additional, Wang, J J, additional, Wang, L-T, additional, Wang, M, additional, Watson, J R, additional, Wei, Y, additional, Weinheimer, C, additional, Weisman, E, additional, Weiss, M, additional, Wenz, D, additional, West, S M, additional, Whitis, T J, additional, Williams, M, additional, Wilson, M J, additional, Winkler, D, additional, Wittweg, C, additional, Wolf, J, additional, Wolf, T, additional, Wolfs, F L H, additional, Woodford, S, additional, Woodward, D, additional, Wright, C J, additional, Wu, V H S, additional, Wu, P, additional, Wüstling, S, additional, Wurm, M, additional, Xia, Q, additional, Xiang, X, additional, Xing, Y, additional, Xu, J, additional, Xu, Z, additional, Xu, D, additional, Yamashita, M, additional, Yamazaki, R, additional, Yan, H, additional, Yang, L, additional, Yang, Y, additional, Ye, J, additional, Yeh, M, additional, Young, I, additional, Yu, H B, additional, Yu, T T, additional, Yuan, L, additional, Zavattini, G, additional, Zerbo, S, additional, Zhang, Y, additional, Zhong, M, additional, Zhou, N, additional, Zhou, X, additional, Zhu, T, additional, Zhu, Y, additional, Zhuang, Y, additional, Zopounidis, J P, additional, Zuber, K, additional, and Zupan, J, additional

Published
2022
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24. Material radiopurity control in the XENONnT experiment

Author

XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D’Andrea, V., Decowski, M. P., Gangi, P. Di, Pede, S. Di, Giovanni, A. Di, Stefano, R. Di, Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hiraide, K., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Ni, K., Oberlack, U., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Dos Santos, J. M. F., Sartorelli, G., Schreiner, J., Schulte, D., Schulze Eißing, H., Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. L., Terliuk, A., Therreau, C., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Westermann, J., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., Zopounidis, J. P., Laubenstein, M., Nisi, S., IoP (FNWI), XENON (IHEF, IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), Aprile, E, Abe, K, Agostini, F, Ahmed Maouloud, S, Alfonsi, M, Althueser, L, Angelino, E, Angevaare, J R, Antochi, V C, Antón Martin, D, Arneodo, F, Baudis, L, Baxter, A L, Bellagamba, L, Biondi, R, Bismark, A, Brown, A, Bruenner, S, Bruno, G, Budnik, R, Capelli, C, Cardoso, J M R, Cichon, D, Cimmino, B, Clark, M, Colijn, A P, Conrad, J, Cuenca-García, J J, Cussonneau, J P, D'Andrea, V, Decowski, M P, Gangi, P Di, Pede, S Di, Giovanni, A Di, Stefano, R Di, Diglio, S, Elykov, A, Farrell, S, Ferella, A D, Fischer, H, Fulgione, W, Gaemers, P, Gaior, R, Galloway, M, Gao, F, Glade-Beucke, R, Grandi, L, Grigat, J, Higuera, A, Hils, C, Hiraide, K, Hoetzsch, L, Howlett, J, Iacovacci, M, Itow, Y, Jakob, J, Joerg, F, Kato, N, Kavrigin, P, Kazama, S, Kobayashi, M, Koltman, G, Kopec, A, Landsman, H, Lang, R F, Levinson, L, Li, I, Liang, S, Lindemann, S, Lindner, M, Liu, K, Lombardi, F, Long, J, Lopes, J A M, Ma, Y, Macolino, C, Mahlstedt, J, Mancuso, A, Manenti, L, Manfredini, A, Marignetti, F, Marrodán Undagoitia, T, Martens, K, Masbou, J, Masson, D, Masson, E, Mastroianni, S, Messina, M, Miuchi, K, Mizukoshi, K, Molinario, A, Moriyama, S, Morå, K, Mosbacher, Y, Murra, M, Ni, K, Oberlack, U, Palacio, J, Peres, R, Pienaar, J, Pierre, M, Pizzella, V, Plante, G, Qi, J, Qin, J, Ramírez García, D, Reichard, S, Rocchetti, A, Rupp, N, Sanchez, L, Dos Santos, J M F, Sartorelli, G, Schreiner, J, Schulte, D, Schulze Eißing, H, Schumann, M, Lavina, L Scotto, Selvi, M, Semeria, F, Shagin, P, Shockley, E, Silva, M, Simgen, H, Takeda, A, Tan, P L, Terliuk, A, Therreau, C, Thers, D, Toschi, F, Trinchero, G, Tunnell, C, Tönnies, F, Valerius, K, Volta, G, Wei, Y, Weinheimer, C, Weiss, M, Wenz, D, Westermann, J, Wittweg, C, Wolf, T, Xu, Z, Yamashita, M, Yang, L, Ye, J, Yuan, L, Zavattini, G, Zhang, Y, Zhong, M, Zhu, T, Zopounidis, J P, Laubenstein, M, and Nisi, S

Subjects
Radioactivity, Xenon1T, Spectrometry, Physics - Instrumentation and Detectors, Radioactivity, Physics and Astronomy (miscellaneous), Spectrometry, Physics, FOS: Physical sciences, Xenon1T, ddc:530, Instrumentation and Detectors (physics.ins-det), Astrophysics - Instrumentation and Methods for Astrophysics, Engineering (miscellaneous), Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

The selection of low-radioactive construction materials is of the utmost importance for rare-event searches and thus critical to the XENONnT experiment. Results of an extensive radioassay program are reported, in which material samples have been screened with gamma-ray spectroscopy, mass spectrometry, and $$^{222}$$ 222 Rn emanation measurements. Furthermore, the cleanliness procedures applied to remove or mitigate surface contamination of detector materials are described. Screening results, used as inputs for a XENONnT Monte Carlo simulation, predict a reduction of materials background ($$\sim $$ ∼ 17%) with respect to its predecessor XENON1T. Through radon emanation measurements, the expected $$^{222}$$ 222 Rn activity concentration in XENONnT is determined to be 4.2 ($$^{+0.5}_{-0.7}$$ - 0.7 + 0.5 ) $$\upmu $$ μ Bq/kg, a factor three lower with respect to XENON1T. This radon concentration will be further suppressed by means of the novel radon distillation system.

Published
2021

25. COMPASS criteria applied to a contemporary cohort of unselected patients with stable coronary artery diseases: Insights from the STARTregistry

Author

De Luca, L, Formigli, D, Meessen, J, Uguccioni, M, Cosentino, N, Paolillo, C, Di Lenarda, A, Colivicchi, F, Gabrielli, D, Gulizia, M, Scherillo, M, Maras, P, Ramani, F, Falcone, C, Passarelli, I, Mauri, S, Calabro, P, Bianchi, R, Di Palma, G, Mascia, F, Vetrano, A, Fusco, A, Proia, E, Aiello, A, Tomai, F, Licitra, R, Petrolini, A, Bosco, B, Magliari, F, Callerame, M, Mazzella, T, Lettica, G, Coco, G, Incao, F, Marinacci, L, D'Addario, S, Tartaglione, S, Ubaldi, S, Sanchez, F, Costa, P, Manca, G, Failla, M, Procaccini, V, Senni, M, Luminita, E, Bonomo, P, Mossa, C, Corda, S, Colavita, A, Trevisonno, G, Vizzari, G, Formaro, C, Nalin, I, De Rosa, F, Fontana, F, Fuscaldo, G, Passamonti, E, Bertella, E, Calvaruso, E, Varani, E, Tani, F, Cicchitelli, G, Paoloni, P, Marziali, A, Campo, G, Tebaldi, M, Biscaglia, S, Di Biase, M, Brunetti, N, Gallotta, A, Mattei, L, Marini, R, Balsemin, F, D'Urbano, M, Naio, R, Vicinelli, P, Arena, G, Mazzini, M, Gigli, N, Miserrafiti, B, Monopoli, A, Mortara, A, Delfino, P, Chioffi, M, Marino, P, Gravellone, M, Barbieri, L, Ledda, A, Geraci, G, Carmina, M, Raisaro, A, Di Giacomo, C, Somaschini, A, Fasano, M, Sannazzaro, M, Arcieri, R, Pantaleoni, M, Leuzzi, C, Gorlato, G, Greco, G, Chiera, A, Ammaturo, T, Malanchini, G, Del Corral, M, Tedesco, L, Pede, S, Urso, L, Piscione, F, Galasso, G, Provasoli, S, Fattore, L, Lucca, G, Cresti, A, Cardillo, A, Fera, M, Vennettilli, F, Gaudio, C, Paravati, V, Caldarola, P, Locuratolo, N, Verlato, R, De Conti, F, Turiano, G, Preti, G, Moretti, L, Silenzi, S, Colonna, G, Picciolo, A, Nicosia, A, Cascone, C, Di Sciascio, G, Mangiacapra, F, Russo, A, Mastroianno, S, Esposito, G, Cosmi, F, D'Orazio, S, Costantini, C, Lanari, A, De Rosa, P, Esposito, L, Bilato, C, Dalla Valle, C, Ceresa, M, Colombo, E, Pennisi, V, Casciola, G, Driussi, M, Bisceglia, T, Scalvini, S, Rivadossi, F, Volpe, M, Comito, F, Scorzoni, D, Grimoldi, P, Lagioia, R, Santoro, D, De Cesare, N, Comotti, T, Poli, A, Martina, P, Musolino, M, Multari, E, Bilardo, G, Scalchi, G, Olivieri, C, Caranci, F, Pavan, D, Ganci, G, Mariani, A, Falchetti, E, Lanzillo, T, Caccavale, A, Bongo, A, Rizzi, A, Favilli, R, Maffei, S, Mallardo, M, Fulgione, C, Bordin, F, Bonmassari, R, Battaia, E, Puzzo, A, Vianello, G, D'Arpino, A, Romei, M, Pajes, G, Petronzelli, S, Ghezzi, F, Brigido, S, Pignatelli, L, Brscic, E, Sori, P, Russo, M, Biancolillo, E, Ignone, G, De Giorgio, N, Campaniello, C, Ponticelli, P, Margonato, A, Gerosa, S, Cutaia, A, Casalicchio, C, Bartolomucci, F, Larosa, C, Spadafina, T, Putignano, A, Se Cristofaro, R, Bernardi, L, Sommariva, L, Celestini, A, Bertucci, C, Marchetti, M, Franceschini Grisolia, E, Ammendolea, C, Carini, M, Scipione, P, Politano, M, Rubino, G, Reina, C, Peccerillo, N, Paloscia, L, D'Alleva, A, Petacchi, R, Pignalosa, M, Lucchetti, D, Di Palma, F, La Mastra, R, Amico, A, De Filippis, M, Fontanella, B, Zanini, G, Casolo, G, Del Meglio, J, Parato, V, Genovesi, E, D'Alimonte, A, Miglioranza, A, Alessandri, N, Moscariello, F, Mauro, C, Sasso, A, Caso, P, Petrillo, C, Napoletano, C, Paparoni, S, Bernardo, V, Serdoz, R, Rotunno, R, Oppo, I, Aloisio, A, Aurelio, A, Licciardello, G, Cassaniti, L, Francese, G, Marcassa, C, Temporelli, P, Villani, R, Zorzoli, F, Mileto, F, De Vecchis, M, Scolozzi, D, Lupi, G, Caruso, D, Rebulla, E, La Fata, B, Anselmi, M, Girardi, P, Borruso, E, Ferrantelli, G, Sassone, B, Bressan, S, Capriolo, M, Pelissero, E, Piancastelli, M, Gobbi, M, Cocco, F, Bruno, M, Berti, S, Lo Surdo, G, Tanzi, P, De Rosa, R, Vilei, E, De Iaco, M, Grassi, G, Zanella, C, Marullo, L, Alfano, G, Pelaggi, P, Talarico, R, Tuccillo, B, Irace, L, Proietti, F, Di Croce, G, Di Lorenzo, L, Zarrilli, A, Bongini, M, Ranise, A, Aprile, A, Fornengo, C, Capogrosso, V, Tranghese, A, Golia, B, Marziano, A, Roncon, L, Picariello, C, Bagni, E, Leci, E, Gregorio, G, Gatto, F, Piemonte, F, Gervasio, F, Navazio, A, Guerri, E, Belmonte, E, Marino, F, Di Belardino, N, Di Nuzzo, M, Epifani, M, Comolatti, G, Conconi, B, Benea, D, Casu, G, Merella, P, Ammirati, M, Corrado, V, Spagnolo, D, Caico, S, Bonizzato, S, Margheri, M, Corrado, L, Antonicelli, R, Ferrigno, C, Merlino, A, Nassiacos, D, Antonelli, A, Marchese, A, Villella, A, Bechi, S, Lo Bianco, F, Bedogni, F, Negro, L, Donato, L, Statile, D, Cassin, M, Fedele, F, Granatelli, A, Calcagno, S, Politi, A, Pani, A, De Luca L., Formigli D., Meessen J., Uguccioni M., Cosentino N., Paolillo C., Di Lenarda A., Colivicchi F., Gabrielli D., Gulizia M. M., Scherillo M., Maras P., Ramani F., Falcone C., Passarelli I., Mauri S., Calabro P., Bianchi R., Di Palma G., Mascia F., Vetrano A., Fusco A., Proia E., Aiello A., Tomai F., Licitra R., Petrolini A., Bosco B., Magliari F., Callerame M., Mazzella T., Lettica G. V., Coco G., Incao F., Marinacci L., D'Addario S., Tartaglione S. N., Ubaldi S., Sanchez F. A., Costa P., Manca G., Failla M., Procaccini V., Senni M., Luminita E. M., Bonomo P., Mossa C., Corda S., Colavita A. R., Trevisonno G., Vizzari G., Formaro C., Nalin I. L., De Rosa F. M., Fontana F., Fuscaldo G. F., Passamonti E., Bertella E., Calvaruso E. V., Varani E., Tani F., Cicchitelli G., Paoloni P., Marziali A., Campo G., Tebaldi M., Biscaglia S., Di Biase M., Brunetti N. D., Gallotta A. M., Mattei L., Marini R., Balsemin F., D'Urbano M., Naio R., Vicinelli P., Arena G., Mazzini M., Gigli N., Miserrafiti B., Monopoli A., Mortara A., Delfino P., Chioffi M. M., Marino P., Gravellone M., Barbieri L., Ledda A., Geraci G., Carmina M. G., Raisaro A. E., Di Giacomo C., Somaschini A., Fasano M. L., Sannazzaro M., Arcieri R., Pantaleoni M., Leuzzi C., Gorlato G., Greco G., Chiera A., Ammaturo T. A., Malanchini G., Del Corral M. P., Tedesco L., Pede S., Urso L. G., Piscione F., Galasso G., Provasoli S., Fattore L., Lucca G., Cresti A., Cardillo A., Fera M. S., Vennettilli F., Gaudio C., Paravati V., Caldarola P., Locuratolo N., Verlato R., De Conti F., Turiano G., Preti G., Moretti L., Silenzi S., Colonna G., Picciolo A., Nicosia A., Cascone C., Di Sciascio G., Mangiacapra F., Russo A., Mastroianno S., Esposito G., Cosmi F., D'Orazio S., Costantini C., Lanari A., De Rosa P., Esposito L., Bilato C., Dalla Valle C., Ceresa M., Colombo E., Pennisi V., Casciola G., Driussi M., Bisceglia T., Scalvini S., Rivadossi F., Volpe M., Comito F., Scorzoni D., Grimoldi P., Lagioia R., Santoro D., De Cesare N., Comotti T., Poli A., Martina P., Musolino M. F., Multari E. I., Bilardo G., Scalchi G., Olivieri C., Caranci F., Pavan D., Ganci G., Mariani A., Falchetti E., Lanzillo T., Caccavale A., Bongo A. S., Rizzi A., Favilli R., Maffei S., Mallardo M., Fulgione C., Bordin F., Bonmassari R., Battaia E., Puzzo A., Vianello G., D'Arpino A., Romei M., Pajes G., Petronzelli S., Ghezzi F., Brigido S., Pignatelli L., Brscic E., Sori P., Russo M., Biancolillo E., Ignone G., De Giorgio N. A., Campaniello C., Ponticelli P., Margonato A., Gerosa S., Cutaia A., Casalicchio C., Bartolomucci F., Larosa C., Spadafina T., Putignano A., Se Cristofaro R., Bernardi L., Sommariva L., Celestini A., Bertucci C. M., Marchetti M., Franceschini Grisolia E., Ammendolea C., Carini M., Scipione P., Politano M., Rubino G., Reina C., Peccerillo N., Paloscia L., D'Alleva A., Petacchi R., Pignalosa M., Lucchetti D., Di Palma F., La Mastra R. A., Amico A. F., De Filippis M., Fontanella B., Zanini G., Casolo G., Del Meglio J., Parato V. M., Genovesi E., D'Alimonte A., Miglioranza A., Alessandri N., Moscariello F., Mauro C., Sasso A., Caso P., Petrillo C., Napoletano C., Paparoni S. R., Bernardo V., Serdoz R., Rotunno R., Oppo I., Aloisio A., Aurelio A., Licciardello G., Cassaniti L., Francese G. M., Marcassa C., Temporelli P. L., Villani R., Zorzoli F., Mileto F., De Vecchis M., Scolozzi D., Lupi G., Caruso D., Rebulla E., La Fata B., Anselmi M., Girardi P., Borruso E., Ferrantelli G., Sassone B., Bressan S., Capriolo M., Pelissero E., Piancastelli M., Gobbi M., Cocco F., Bruno M. G., Berti S., Lo Surdo G., Tanzi P., De Rosa R., Vilei E., De Iaco M. R., Grassi G., Zanella C., Marullo L., Alfano G., Pelaggi P., Talarico R., Tuccillo B., Irace L., Proietti F., Di Croce G., Di Lorenzo L., Zarrilli A., Bongini M., Ranise A., Aprile A., Fornengo C., Capogrosso V., Tranghese A., Golia B., Marziano A., Roncon L., Picariello C., Bagni E., Leci E., Gregorio G., Gatto F., Piemonte F., Gervasio F., Navazio A., Guerri E., Belmonte E., Marino F., Di Belardino N., Di Nuzzo M. R., Epifani M., Comolatti G., Conconi B., Benea D., Casu G., Merella P., Ammirati M. A., Corrado V. M., Spagnolo D., Caico S. I., Bonizzato S., Margheri M., Corrado L., Antonicelli R., Ferrigno C., Merlino A., Nassiacos D., Antonelli A., Marchese A., Villella A., Bechi S., Lo Bianco F., Bedogni F., Negro L., Donato L., Statile D., Cassin M., Fedele F., Granatelli A., Calcagno S., Politi A., Pani A., De Luca, L, Formigli, D, Meessen, J, Uguccioni, M, Cosentino, N, Paolillo, C, Di Lenarda, A, Colivicchi, F, Gabrielli, D, Gulizia, M, Scherillo, M, Maras, P, Ramani, F, Falcone, C, Passarelli, I, Mauri, S, Calabro, P, Bianchi, R, Di Palma, G, Mascia, F, Vetrano, A, Fusco, A, Proia, E, Aiello, A, Tomai, F, Licitra, R, Petrolini, A, Bosco, B, Magliari, F, Callerame, M, Mazzella, T, Lettica, G, Coco, G, Incao, F, Marinacci, L, D'Addario, S, Tartaglione, S, Ubaldi, S, Sanchez, F, Costa, P, Manca, G, Failla, M, Procaccini, V, Senni, M, Luminita, E, Bonomo, P, Mossa, C, Corda, S, Colavita, A, Trevisonno, G, Vizzari, G, Formaro, C, Nalin, I, De Rosa, F, Fontana, F, Fuscaldo, G, Passamonti, E, Bertella, E, Calvaruso, E, Varani, E, Tani, F, Cicchitelli, G, Paoloni, P, Marziali, A, Campo, G, Tebaldi, M, Biscaglia, S, Di Biase, M, Brunetti, N, Gallotta, A, Mattei, L, Marini, R, Balsemin, F, D'Urbano, M, Naio, R, Vicinelli, P, Arena, G, Mazzini, M, Gigli, N, Miserrafiti, B, Monopoli, A, Mortara, A, Delfino, P, Chioffi, M, Marino, P, Gravellone, M, Barbieri, L, Ledda, A, Geraci, G, Carmina, M, Raisaro, A, Di Giacomo, C, Somaschini, A, Fasano, M, Sannazzaro, M, Arcieri, R, Pantaleoni, M, Leuzzi, C, Gorlato, G, Greco, G, Chiera, A, Ammaturo, T, Malanchini, G, Del Corral, M, Tedesco, L, Pede, S, Urso, L, Piscione, F, Galasso, G, Provasoli, S, Fattore, L, Lucca, G, Cresti, A, Cardillo, A, Fera, M, Vennettilli, F, Gaudio, C, Paravati, V, Caldarola, P, Locuratolo, N, Verlato, R, De Conti, F, Turiano, G, Preti, G, Moretti, L, Silenzi, S, Colonna, G, Picciolo, A, Nicosia, A, Cascone, C, Di Sciascio, G, Mangiacapra, F, Russo, A, Mastroianno, S, Esposito, G, Cosmi, F, D'Orazio, S, Costantini, C, Lanari, A, De Rosa, P, Esposito, L, Bilato, C, Dalla Valle, C, Ceresa, M, Colombo, E, Pennisi, V, Casciola, G, Driussi, M, Bisceglia, T, Scalvini, S, Rivadossi, F, Volpe, M, Comito, F, Scorzoni, D, Grimoldi, P, Lagioia, R, Santoro, D, De Cesare, N, Comotti, T, Poli, A, Martina, P, Musolino, M, Multari, E, Bilardo, G, Scalchi, G, Olivieri, C, Caranci, F, Pavan, D, Ganci, G, Mariani, A, Falchetti, E, Lanzillo, T, Caccavale, A, Bongo, A, Rizzi, A, Favilli, R, Maffei, S, Mallardo, M, Fulgione, C, Bordin, F, Bonmassari, R, Battaia, E, Puzzo, A, Vianello, G, D'Arpino, A, Romei, M, Pajes, G, Petronzelli, S, Ghezzi, F, Brigido, S, Pignatelli, L, Brscic, E, Sori, P, Russo, M, Biancolillo, E, Ignone, G, De Giorgio, N, Campaniello, C, Ponticelli, P, Margonato, A, Gerosa, S, Cutaia, A, Casalicchio, C, Bartolomucci, F, Larosa, C, Spadafina, T, Putignano, A, Se Cristofaro, R, Bernardi, L, Sommariva, L, Celestini, A, Bertucci, C, Marchetti, M, Franceschini Grisolia, E, Ammendolea, C, Carini, M, Scipione, P, Politano, M, Rubino, G, Reina, C, Peccerillo, N, Paloscia, L, D'Alleva, A, Petacchi, R, Pignalosa, M, Lucchetti, D, Di Palma, F, La Mastra, R, Amico, A, De Filippis, M, Fontanella, B, Zanini, G, Casolo, G, Del Meglio, J, Parato, V, Genovesi, E, D'Alimonte, A, Miglioranza, A, Alessandri, N, Moscariello, F, Mauro, C, Sasso, A, Caso, P, Petrillo, C, Napoletano, C, Paparoni, S, Bernardo, V, Serdoz, R, Rotunno, R, Oppo, I, Aloisio, A, Aurelio, A, Licciardello, G, Cassaniti, L, Francese, G, Marcassa, C, Temporelli, P, Villani, R, Zorzoli, F, Mileto, F, De Vecchis, M, Scolozzi, D, Lupi, G, Caruso, D, Rebulla, E, La Fata, B, Anselmi, M, Girardi, P, Borruso, E, Ferrantelli, G, Sassone, B, Bressan, S, Capriolo, M, Pelissero, E, Piancastelli, M, Gobbi, M, Cocco, F, Bruno, M, Berti, S, Lo Surdo, G, Tanzi, P, De Rosa, R, Vilei, E, De Iaco, M, Grassi, G, Zanella, C, Marullo, L, Alfano, G, Pelaggi, P, Talarico, R, Tuccillo, B, Irace, L, Proietti, F, Di Croce, G, Di Lorenzo, L, Zarrilli, A, Bongini, M, Ranise, A, Aprile, A, Fornengo, C, Capogrosso, V, Tranghese, A, Golia, B, Marziano, A, Roncon, L, Picariello, C, Bagni, E, Leci, E, Gregorio, G, Gatto, F, Piemonte, F, Gervasio, F, Navazio, A, Guerri, E, Belmonte, E, Marino, F, Di Belardino, N, Di Nuzzo, M, Epifani, M, Comolatti, G, Conconi, B, Benea, D, Casu, G, Merella, P, Ammirati, M, Corrado, V, Spagnolo, D, Caico, S, Bonizzato, S, Margheri, M, Corrado, L, Antonicelli, R, Ferrigno, C, Merlino, A, Nassiacos, D, Antonelli, A, Marchese, A, Villella, A, Bechi, S, Lo Bianco, F, Bedogni, F, Negro, L, Donato, L, Statile, D, Cassin, M, Fedele, F, Granatelli, A, Calcagno, S, Politi, A, Pani, A, De Luca L., Formigli D., Meessen J., Uguccioni M., Cosentino N., Paolillo C., Di Lenarda A., Colivicchi F., Gabrielli D., Gulizia M. M., Scherillo M., Maras P., Ramani F., Falcone C., Passarelli I., Mauri S., Calabro P., Bianchi R., Di Palma G., Mascia F., Vetrano A., Fusco A., Proia E., Aiello A., Tomai F., Licitra R., Petrolini A., Bosco B., Magliari F., Callerame M., Mazzella T., Lettica G. V., Coco G., Incao F., Marinacci L., D'Addario S., Tartaglione S. N., Ubaldi S., Sanchez F. A., Costa P., Manca G., Failla M., Procaccini V., Senni M., Luminita E. M., Bonomo P., Mossa C., Corda S., Colavita A. R., Trevisonno G., Vizzari G., Formaro C., Nalin I. L., De Rosa F. M., Fontana F., Fuscaldo G. F., Passamonti E., Bertella E., Calvaruso E. V., Varani E., Tani F., Cicchitelli G., Paoloni P., Marziali A., Campo G., Tebaldi M., Biscaglia S., Di Biase M., Brunetti N. D., Gallotta A. M., Mattei L., Marini R., Balsemin F., D'Urbano M., Naio R., Vicinelli P., Arena G., Mazzini M., Gigli N., Miserrafiti B., Monopoli A., Mortara A., Delfino P., Chioffi M. M., Marino P., Gravellone M., Barbieri L., Ledda A., Geraci G., Carmina M. G., Raisaro A. E., Di Giacomo C., Somaschini A., Fasano M. L., Sannazzaro M., Arcieri R., Pantaleoni M., Leuzzi C., Gorlato G., Greco G., Chiera A., Ammaturo T. A., Malanchini G., Del Corral M. P., Tedesco L., Pede S., Urso L. G., Piscione F., Galasso G., Provasoli S., Fattore L., Lucca G., Cresti A., Cardillo A., Fera M. S., Vennettilli F., Gaudio C., Paravati V., Caldarola P., Locuratolo N., Verlato R., De Conti F., Turiano G., Preti G., Moretti L., Silenzi S., Colonna G., Picciolo A., Nicosia A., Cascone C., Di Sciascio G., Mangiacapra F., Russo A., Mastroianno S., Esposito G., Cosmi F., D'Orazio S., Costantini C., Lanari A., De Rosa P., Esposito L., Bilato C., Dalla Valle C., Ceresa M., Colombo E., Pennisi V., Casciola G., Driussi M., Bisceglia T., Scalvini S., Rivadossi F., Volpe M., Comito F., Scorzoni D., Grimoldi P., Lagioia R., Santoro D., De Cesare N., Comotti T., Poli A., Martina P., Musolino M. F., Multari E. I., Bilardo G., Scalchi G., Olivieri C., Caranci F., Pavan D., Ganci G., Mariani A., Falchetti E., Lanzillo T., Caccavale A., Bongo A. S., Rizzi A., Favilli R., Maffei S., Mallardo M., Fulgione C., Bordin F., Bonmassari R., Battaia E., Puzzo A., Vianello G., D'Arpino A., Romei M., Pajes G., Petronzelli S., Ghezzi F., Brigido S., Pignatelli L., Brscic E., Sori P., Russo M., Biancolillo E., Ignone G., De Giorgio N. A., Campaniello C., Ponticelli P., Margonato A., Gerosa S., Cutaia A., Casalicchio C., Bartolomucci F., Larosa C., Spadafina T., Putignano A., Se Cristofaro R., Bernardi L., Sommariva L., Celestini A., Bertucci C. M., Marchetti M., Franceschini Grisolia E., Ammendolea C., Carini M., Scipione P., Politano M., Rubino G., Reina C., Peccerillo N., Paloscia L., D'Alleva A., Petacchi R., Pignalosa M., Lucchetti D., Di Palma F., La Mastra R. A., Amico A. F., De Filippis M., Fontanella B., Zanini G., Casolo G., Del Meglio J., Parato V. M., Genovesi E., D'Alimonte A., Miglioranza A., Alessandri N., Moscariello F., Mauro C., Sasso A., Caso P., Petrillo C., Napoletano C., Paparoni S. R., Bernardo V., Serdoz R., Rotunno R., Oppo I., Aloisio A., Aurelio A., Licciardello G., Cassaniti L., Francese G. M., Marcassa C., Temporelli P. L., Villani R., Zorzoli F., Mileto F., De Vecchis M., Scolozzi D., Lupi G., Caruso D., Rebulla E., La Fata B., Anselmi M., Girardi P., Borruso E., Ferrantelli G., Sassone B., Bressan S., Capriolo M., Pelissero E., Piancastelli M., Gobbi M., Cocco F., Bruno M. G., Berti S., Lo Surdo G., Tanzi P., De Rosa R., Vilei E., De Iaco M. R., Grassi G., Zanella C., Marullo L., Alfano G., Pelaggi P., Talarico R., Tuccillo B., Irace L., Proietti F., Di Croce G., Di Lorenzo L., Zarrilli A., Bongini M., Ranise A., Aprile A., Fornengo C., Capogrosso V., Tranghese A., Golia B., Marziano A., Roncon L., Picariello C., Bagni E., Leci E., Gregorio G., Gatto F., Piemonte F., Gervasio F., Navazio A., Guerri E., Belmonte E., Marino F., Di Belardino N., Di Nuzzo M. R., Epifani M., Comolatti G., Conconi B., Benea D., Casu G., Merella P., Ammirati M. A., Corrado V. M., Spagnolo D., Caico S. I., Bonizzato S., Margheri M., Corrado L., Antonicelli R., Ferrigno C., Merlino A., Nassiacos D., Antonelli A., Marchese A., Villella A., Bechi S., Lo Bianco F., Bedogni F., Negro L., Donato L., Statile D., Cassin M., Fedele F., Granatelli A., Calcagno S., Politi A., and Pani A.

Abstract

Aims Recently, the cardiovascular outcomes for people using anticoagulation strategies (COMPASS) trial demonstrated that dual therapy reduced cardiovascular outcomes compared with aspirin alone in patients with stable atherosclerotic disease. Methods and We sought to assess the proportion of patients eligible for the COMPASS trial and to compare the epidemiology results and outcome of these patients with those without COMPASS inclusion or with any exclusion criteria in a contemporary, nationwide cohort of patients with stable coronary artery disease. Among the 4068 patients with detailed information allowing evaluation of eligibility, 1416 (34.8%) did not fulfil the inclusion criteria (COMPASS-Not-Included), 841 (20.7%) had exclusion criteria (COMPASS-Excluded), and the remaining 1811 (44.5%) were classified as COMPASS-Like. At 1 year, the incidence of major adverse cardiovascular event (MACE), a composite of cardiovascular death, myocardial infarction, and stroke, was 0.9% in the COMPASS-Not-Included and 2.0% in the COMPASS-Like (P = 0.01), and 5.0% in the COMPASS-Excluded group (P < 0.0001 for all comparisons). Among the COMPASS-Like population, patients with multiple COMPASS enrichment criteria presented a significant increase in the risk of MACE (from 1.0% to 3.3% in those with 1 and >_3 criteria, respectively; P = 0.012), and a modest absolute increase in major bleeding risk (from 0.2% to 0.4%, respectively; P = 0.46). Conclusion In a contemporary real-world cohort registry of stable coronary artery disease, most patients resulted as eligible for the COMPASS. These patients presented a considerable annual risk of MACE that consistently increases in the presence of multiple risk factors.

Published
2021

26. Double-weak decays of <math><mmultiscripts><mi>Xe</mi><mprescripts></mprescripts><none></none><mn>124</mn></mmultiscripts></math> and <math><mmultiscripts><mi>Xe</mi><mprescripts></mprescripts><none></none><mn>136</mn></mmultiscripts></math> in the XENON1T and XENONnT experiments

Author

Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J.R., Antochi, V.C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A.L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J.M.R., Cichon, D., Clark, M., Colijn, A.P., Conrad, J., Cuenca-García, J.J., Cussonneau, J.P., D'Andrea, V., Decowski, M.P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A.D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R.F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J.A.M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J.M.F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P.L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., and Zhu, T.

Abstract

We present results on the search for two-neutrino double-electron capture (2νECEC) of Xe124 and neutrinoless double-β decay (0νββ) of Xe136 in XENON1T. We consider captures from the K shell up to the N shell in the 2νECEC signal model and measure a total half-life of T1/22νECEC=(1.1±0.2stat±0.1sys)×1022yr with a 0.87kgyr isotope exposure. The statistical significance of the signal is 7.0σ. We use XENON1T data with 36.16kgyr of Xe136 exposure to search for 0νββ. We find no evidence of a signal and set a lower limit on the half-life of T1/20νββ>1.2×1024yrat90%CL. This is the best result from a dark matter detector without an enriched target to date. We also report projections on the sensitivity of XENONnT to 0νββ. Assuming a 275kgyr Xe136 exposure, the expected sensitivity is T1/20νββ>2.1×1025yrat90%CL, corresponding to an effective Majorana mass range of 〈mββ〉<(0.19–0.59)eV/c2.

Published
2022

27. Double-weak decays of 124Xe and 136Xe in the XENON1T and XENONnT experiments

Author

Aprile, E., Angevaare, J.R., Bruenner, S., Colijn, A.P., Decowski, M.P., Di Pede, S., Gaemers, P., Wolf, T., IoP (FNWI), XENON (IHEF, IoP, FNWI), and Astroparticle Physics (IHEF, IoP, FNWI)

Abstract

We present results on the search for two-neutrino double-electron capture (2νECEC) of 124Xe and neutrinoless double-β decay (0νββ) of 136Xe in XENON1T. We consider captures from the K shell up to the N shell in the 2νECEC signal model and measure a total half-life of T2νECEC1/2=(1.1±0.2stat±0.1sys)×1022 yr with a 0.87 kg yr isotope exposure. The statistical significance of the signal is 7.0σ. We use XENON1T data with 36.16 kg yr of 136Xe exposure to search for 0νββ. We find no evidence of a signal and set a lower limit on the half-life of T0νββ1/2>1.2×1024 yr at 90% CL. This is the best result from a dark matter detector without an enriched target to date. We also report projections on the sensitivity of XENONnT to 0νββ. Assuming a 275 kg yr 136Xe exposure, the expected sensitivity is T0νββ1/2>2.1×1025 yr at 90% CL, corresponding to an effective Majorana mass range of ⟨mββ⟩

Published
2022

28. Emission of single and few electrons in XENON1T and limits on light dark matter

Author

Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, Vasile C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, Jan, Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L, Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, Ashley, Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Linder, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, Jörn, Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simigen, H., Takeda, A., Tan, Pueh-Leng, Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnel, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., Zopounidis, J. P., Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, Vasile C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, Jan, Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L, Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, Ashley, Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Linder, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, Jörn, Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simigen, H., Takeda, A., Tan, Pueh-Leng, Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnel, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., and Zopounidis, J. P.

Abstract

Delayed single- and few-electron emissions plague dual-phase time projection chambers, limiting their potential to search for light-mass dark matter. This paper examines the origins of these events in the XENON1T experiment. Characterization of the intensity of delayed electron backgrounds shows that the resulting emissions are correlated, in time and position, with high-energy events and can effectively be vetoed. In this work we extend previous S2-only analyses down to a single electron. From this analysis, after removing the correlated backgrounds, we observe rates <30 events/(electron×kg×day) in the region of interest spanning 1 to 5 electrons. We derive 90% confidence upper limits for dark matter-electron scattering, first direct limits on the electric dipole, magnetic dipole, and anapole interactions, and bosonic dark matter models, where we exclude new parameter space for dark photons and solar dark photons.

Published
2022
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29. Application and modeling of an online distillation method to reduce krypton and argon in XENON1T

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, Vasile C., Martin, D. Anton, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, Jan, Cuenca-Garcia, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Form, S., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Huhmann, C., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, Ashley, Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, S., Li, I., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, Jörn, Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodan Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Mora, K., Mosbacher, Y., Murra, M., Mueller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramirez Garcia, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J. M. F., Sartorelli, G., Schreiner, J., Schulte, D., Schulze Eissing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, Pueh-Leng, Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tonnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, Vasile C., Martin, D. Anton, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, Jan, Cuenca-Garcia, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Form, S., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Huhmann, C., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, Ashley, Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, S., Li, I., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, Jörn, Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodan Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Mora, K., Mosbacher, Y., Murra, M., Mueller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramirez Garcia, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J. M. F., Sartorelli, G., Schreiner, J., Schulte, D., Schulze Eissing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, Pueh-Leng, Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tonnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., and Zhu, T.

Abstract

A novel online distillation technique was developed for the XENON1T dark matter experiment to reduce intrinsic background components more volatile than xenon, such as krypton or argon, while the detector was operating. The method is based on a continuous purification of the gaseous volume of the detector system using the XENON1T cryogenic distillation column. A krypton-in-xenon concentration of (360 +/- 60) ppq was achieved. It is the lowest concentration measured in the fiducial volume of an operating dark matter detector to date. A model was developed and fitted to the data to describe the krypton evolution in the liquid and gas volumes of the detector system for several operation modes over the time span of 550 days, including the commissioning and science runs of XENON1T. The online distillation was also successfully applied to remove Ar-37 after its injection for a low-energy calibration in XENON1T. This makes the usage of Ar-37 as a regular calibration source possible in the future. The online distillation can be applied to next-generation liquid xenon time projection chamber experiments to remove krypton prior to, or during, any science run. The model developed here allows further optimization of the distillation strategy for future large-scale detectors.

Published
2022
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30. Application and modeling of an online distillation method to reduce krypton and argon in XENON1T

Author

Aprile, E, primary, Abe, K, additional, Agostini, F, additional, Maouloud, S Ahmed, additional, Alfonsi, M, additional, Althueser, L, additional, Angelino, E, additional, Angevaare, J R, additional, Antochi, V C, additional, Martin, D Antón, additional, Arneodo, F, additional, Baudis, L, additional, Baxter, A L, additional, Bellagamba, L, additional, Bernard, A, additional, Biondi, R, additional, Bismark, A, additional, Brown, A, additional, Bruenner, S, additional, Bruno, G, additional, Budnik, R, additional, Capelli, C, additional, Cardoso, J M R, additional, Cichon, D, additional, Cimmino, B, additional, Clark, M, additional, Colijn, A P, additional, Conrad, J, additional, Cuenca-García, J J, additional, Cussonneau, J P, additional, D’Andrea, V, additional, Decowski, M P, additional, Di Gangi, P, additional, Di Pede, S, additional, Di Giovanni, A, additional, Di Stefano, R, additional, Diglio, S, additional, Elykov, A, additional, Farrell, S, additional, Ferella, A D, additional, Fischer, H, additional, Form, S, additional, Fulgione, W, additional, Gaemers, P, additional, Gaior, R, additional, Galloway, M, additional, Gao, F, additional, Glade-Beucke, R, additional, Grandi, L, additional, Grigat, J, additional, Higuera, A, additional, Hils, C, additional, Hoetzsch, L, additional, Howlett, J, additional, Huhmann, C, additional, Iacovacci, M, additional, Itow, Y, additional, Jakob, J, additional, Joerg, F, additional, Joy, A, additional, Kato, N, additional, Kavrigin, P, additional, Kazama, S, additional, Kobayashi, M, additional, Koltman, G, additional, Kopec, A, additional, Landsman, H, additional, Lang, R F, additional, Levinson, L, additional, Li, S, additional, Li, I, additional, Liang, S, additional, Lindemann, S, additional, Lindner, M, additional, Liu, K, additional, Lombardi, F, additional, Long, J, additional, Lopes, J A M, additional, Ma, Y, additional, Macolino, C, additional, Mahlstedt, J, additional, Mancuso, A, additional, Manenti, L, additional, Manfredini, A, additional, Marignetti, F, additional, Undagoitia, T Marrodán, additional, Martens, K, additional, Masbou, J, additional, Masson, D, additional, Masson, E, additional, Mastroianni, S, additional, Messina, M, additional, Miuchi, K, additional, Mizukoshi, K, additional, Molinario, A, additional, Moriyama, S, additional, Morå, K, additional, Mosbacher, Y, additional, Murra, M, additional, Müller, J, additional, Ni, K, additional, Oberlack, U, additional, Paetsch, B, additional, Palacio, J, additional, Peres, R, additional, Pienaar, J, additional, Pierre, M, additional, Pizzella, V, additional, Plante, G, additional, Qi, J, additional, Qin, J, additional, García, D Ramírez, additional, Reichard, S, additional, Rocchetti, A, additional, Rupp, N, additional, Sanchez, L, additional, dos Santos, J M F, additional, Sartorelli, G, additional, Schreiner, J, additional, Schulte, D, additional, Eißing, H Schulze, additional, Schumann, M, additional, Lavina, L Scotto, additional, Selvi, M, additional, Semeria, F, additional, Shagin, P, additional, Shockley, E, additional, Silva, M, additional, Simgen, H, additional, Takeda, A, additional, Tan, P-L, additional, Terliuk, A, additional, Thers, D, additional, Toschi, F, additional, Trinchero, G, additional, Tunnell, C, additional, Tönnies, F, additional, Valerius, K, additional, Volta, G, additional, Wei, Y, additional, Weinheimer, C, additional, Weiss, M, additional, Wenz, D, additional, Wittweg, C, additional, Wolf, T, additional, Xu, Z, additional, Yamashita, M, additional, Yang, L, additional, Ye, J, additional, Yuan, L, additional, Zavattini, G, additional, Zhang, Y, additional, Zhong, M, additional, and Zhu, T, additional

Published
2022
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31. Double-weak decays of Xe 124 and Xe 136 in the XENON1T and XENONnT experiments

Author

Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Anton Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-Garcia, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodan Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Mora, K., Mosbacher, Y., Murra, M., Muller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramirez Garcia, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eissing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tonnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., and Zhu, T.

Published
2022

32. An approximate likelihood for nuclear recoil searches with XENON1T data

Author

XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D’Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J. M. F., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., and Zhu, T.

Subjects
Physics, ddc:530
Abstract

The XENON collaboration has published stringent limits on specific dark matter – nucleon recoil spectra from dark matter recoiling on the liquid xenon detector target. In this paper, we present an approximate likelihood for the XENON1T 1 t-year nuclear recoil search applicable to any nuclear recoil spectrum. Alongside this paper, we publish data and code to compute upper limits using the method we present. The approximate likelihood is constructed in bins of reconstructed energy, profiled along the signal expectation in each bin. This approach can be used to compute an approximate likelihood and therefore most statistical results for any nuclear recoil spectrum. Computing approximate results with this method is approximately three orders of magnitude faster than the likelihood used in the original publications of XENON1T, where limits were set for specific families of recoil spectra. Using this same method, we include toy Monte Carlo simulation-derived binwise likelihoods for the upcoming XENONnT experiment that can similarly be used to assess the sensitivity to arbitrary nuclear recoil signatures in its eventual 20 t-year exposure.

Published
2022
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33. Emission of single and few electrons in XENON1T and limits on light dark matter

Author

XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D’Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P.-L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., and Zopounidis, J. P.

Subjects
Physics, ddc:530
Abstract

Delayed single- and few-electron emissions plague dual-phase time projection chambers, limiting their potential to search for light-mass dark matter. This paper examines the origins of these events in the XENON1T experiment. Characterization of the intensity of delayed electron backgrounds shows that the resulting emissions are correlated, in time and position, with high-energy events and can effectively be vetoed. In this work we extend previous S2-only analyses down to a single electron. From this analysis, after removing the correlated backgrounds, we observe rates

Published
2022
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34. Double-Weak Decays of 124 124 Xe and 136 136 Xe in the XENON1T and XENONnT Experiments

Author

Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Ant??n., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-Garcia, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrod??n., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Mor??, K., Mosbacher, Y., Murra, M., Muller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ram??rez Garcoa, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Ei??ing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., T??nnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., and Zhu, T.

Published
2022

35. Double-weak decays of $^{124}$Xe and $^{136}$Xe in the XENON1T and XENONnT experiments

Author

XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., dos Santos, J. M. F., Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P.-L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., and Zhu, T.

Subjects
Physics, ddc:530
Published
2022
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37. COMPASS criteria applied to a contemporary cohort of unselected patients with stable coronary artery diseases: Insights from the STARTregistry

Author

De Luca L., Formigli D., Meessen J., Uguccioni M., Cosentino N., Paolillo C., Di Lenarda A., Colivicchi F., Gabrielli D., Gulizia M. M., Scherillo M., Maras P., Ramani F., Falcone C., Passarelli I., Mauri S., Calabro P., Bianchi R., Di Palma G., Mascia F., Vetrano A., Fusco A., Proia E., Aiello A., Tomai F., Licitra R., Petrolini A., Bosco B., Magliari F., Callerame M., Mazzella T., Lettica G. V., Coco G., Incao F., Marinacci L., D'Addario S., Tartaglione S. N., Ubaldi S., Sanchez F. A., Costa P., Manca G., Failla M., Procaccini V., Senni M., Luminita E. M., Bonomo P., Mossa C., Corda S., Colavita A. R., Trevisonno G., Vizzari G., Formaro C., Nalin I. L., De Rosa F. M., Fontana F., Fuscaldo G. F., Passamonti E., Bertella E., Calvaruso E. V., Varani E., Tani F., Cicchitelli G., Paoloni P., Marziali A., Campo G., Tebaldi M., Biscaglia S., Di Biase M., Brunetti N. D., Gallotta A. M., Mattei L., Marini R., Balsemin F., D'Urbano M., Naio R., Vicinelli P., Arena G., Mazzini M., Gigli N., Miserrafiti B., Monopoli A., Mortara A., Delfino P., Chioffi M. M., Marino P., Gravellone M., Barbieri L., Ledda A., Geraci G., Carmina M. G., Raisaro A. E., Di Giacomo C., Somaschini A., Fasano M. L., Sannazzaro M., Arcieri R., Pantaleoni M., Leuzzi C., Gorlato G., Greco G., Chiera A., Ammaturo T. A., Malanchini G., Del Corral M. P., Tedesco L., Pede S., Urso L. G., Piscione F., Galasso G., Provasoli S., Fattore L., Lucca G., Cresti A., Cardillo A., Fera M. S., Vennettilli F., Gaudio C., Paravati V., Caldarola P., Locuratolo N., Verlato R., De Conti F., Turiano G., Preti G., Moretti L., Silenzi S., Colonna G., Picciolo A., Nicosia A., Cascone C., Di Sciascio G., Mangiacapra F., Russo A., Mastroianno S., Esposito G., Cosmi F., D'Orazio S., Costantini C., Lanari A., De Rosa P., Esposito L., Bilato C., Dalla Valle C., Ceresa M., Colombo E., Pennisi V., Casciola G., Driussi M., Bisceglia T., Scalvini S., Rivadossi F., Volpe M., Comito F., Scorzoni D., Grimoldi P., Lagioia R., Santoro D., De Cesare N., Comotti T., Poli A., Martina P., Musolino M. F., Multari E. I., Bilardo G., Scalchi G., Olivieri C., Caranci F., Pavan D., Ganci G., Mariani A., Falchetti E., Lanzillo T., Caccavale A., Bongo A. S., Rizzi A., Favilli R., Maffei S., Mallardo M., Fulgione C., Bordin F., Bonmassari R., Battaia E., Puzzo A., Vianello G., D'Arpino A., Romei M., Pajes G., Petronzelli S., Ghezzi F., Brigido S., Pignatelli L., Brscic E., Sori P., Russo M., Biancolillo E., Ignone G., De Giorgio N. A., Campaniello C., Ponticelli P., Margonato A., Gerosa S., Cutaia A., Casalicchio C., Bartolomucci F., Larosa C., Spadafina T., Putignano A., Se Cristofaro R., Bernardi L., Sommariva L., Celestini A., Bertucci C. M., Marchetti M., Franceschini Grisolia E., Ammendolea C., Carini M., Scipione P., Politano M., Rubino G., Reina C., Peccerillo N., Paloscia L., D'Alleva A., Petacchi R., Pignalosa M., Lucchetti D., Di Palma F., La Mastra R. A., Amico A. F., De Filippis M., Fontanella B., Zanini G., Casolo G., Del Meglio J., Parato V. M., Genovesi E., D'Alimonte A., Miglioranza A., Alessandri N., Moscariello F., Mauro C., Sasso A., Caso P., Petrillo C., Napoletano C., Paparoni S. R., Bernardo V., Serdoz R., Rotunno R., Oppo I., Aloisio A., Aurelio A., Licciardello G., Cassaniti L., Francese G. M., Marcassa C., Temporelli P. L., Villani R., Zorzoli F., Mileto F., De Vecchis M., Scolozzi D., Lupi G., Caruso D., Rebulla E., La Fata B., Anselmi M., Girardi P., Borruso E., Ferrantelli G., Sassone B., Bressan S., Capriolo M., Pelissero E., Piancastelli M., Gobbi M., Cocco F., Bruno M. G., Berti S., Lo Surdo G., Tanzi P., De Rosa R., Vilei E., De Iaco M. R., Grassi G., Zanella C., Marullo L., Alfano G., Pelaggi P., Talarico R., Tuccillo B., Irace L., Proietti F., Di Croce G., Di Lorenzo L., Zarrilli A., Bongini M., Ranise A., Aprile A., Fornengo C., Capogrosso V., Tranghese A., Golia B., Marziano A., Roncon L., Picariello C., Bagni E., Leci E., Gregorio G., Gatto F., Piemonte F., Gervasio F., Navazio A., Guerri E., Belmonte E., Marino F., Di Belardino N., Di Nuzzo M. R., Epifani M., Comolatti G., Conconi B., Benea D., Casu G., Merella P., Ammirati M. A., Corrado V. M., Spagnolo D., Caico S. I., Bonizzato S., Margheri M., Corrado L., Antonicelli R., Ferrigno C., Merlino A., Nassiacos D., Antonelli A., Marchese A., Villella A., Bechi S., Lo Bianco F., Bedogni F., Negro L., Donato L., Statile D., Cassin M., Fedele F., Granatelli A., Calcagno S., Politi A., Pani A., De Luca, L, Formigli, D, Meessen, J, Uguccioni, M, Cosentino, N, Paolillo, C, Di Lenarda, A, Colivicchi, F, Gabrielli, D, Gulizia, M, Scherillo, M, Maras, P, Ramani, F, Falcone, C, Passarelli, I, Mauri, S, Calabro, P, Bianchi, R, Di Palma, G, Mascia, F, Vetrano, A, Fusco, A, Proia, E, Aiello, A, Tomai, F, Licitra, R, Petrolini, A, Bosco, B, Magliari, F, Callerame, M, Mazzella, T, Lettica, G, Coco, G, Incao, F, Marinacci, L, D'Addario, S, Tartaglione, S, Ubaldi, S, Sanchez, F, Costa, P, Manca, G, Failla, M, Procaccini, V, Senni, M, Luminita, E, Bonomo, P, Mossa, C, Corda, S, Colavita, A, Trevisonno, G, Vizzari, G, Formaro, C, Nalin, I, De Rosa, F, Fontana, F, Fuscaldo, G, Passamonti, E, Bertella, E, Calvaruso, E, Varani, E, Tani, F, Cicchitelli, G, Paoloni, P, Marziali, A, Campo, G, Tebaldi, M, Biscaglia, S, Di Biase, M, Brunetti, N, Gallotta, A, Mattei, L, Marini, R, Balsemin, F, D'Urbano, M, Naio, R, Vicinelli, P, Arena, G, Mazzini, M, Gigli, N, Miserrafiti, B, Monopoli, A, Mortara, A, Delfino, P, Chioffi, M, Marino, P, Gravellone, M, Barbieri, L, Ledda, A, Geraci, G, Carmina, M, Raisaro, A, Di Giacomo, C, Somaschini, A, Fasano, M, Sannazzaro, M, Arcieri, R, Pantaleoni, M, Leuzzi, C, Gorlato, G, Greco, G, Chiera, A, Ammaturo, T, Malanchini, G, Del Corral, M, Tedesco, L, Pede, S, Urso, L, Piscione, F, Galasso, G, Provasoli, S, Fattore, L, Lucca, G, Cresti, A, Cardillo, A, Fera, M, Vennettilli, F, Gaudio, C, Paravati, V, Caldarola, P, Locuratolo, N, Verlato, R, De Conti, F, Turiano, G, Preti, G, Moretti, L, Silenzi, S, Colonna, G, Picciolo, A, Nicosia, A, Cascone, C, Di Sciascio, G, Mangiacapra, F, Russo, A, Mastroianno, S, Esposito, G, Cosmi, F, D'Orazio, S, Costantini, C, Lanari, A, De Rosa, P, Esposito, L, Bilato, C, Dalla Valle, C, Ceresa, M, Colombo, E, Pennisi, V, Casciola, G, Driussi, M, Bisceglia, T, Scalvini, S, Rivadossi, F, Volpe, M, Comito, F, Scorzoni, D, Grimoldi, P, Lagioia, R, Santoro, D, De Cesare, N, Comotti, T, Poli, A, Martina, P, Musolino, M, Multari, E, Bilardo, G, Scalchi, G, Olivieri, C, Caranci, F, Pavan, D, Ganci, G, Mariani, A, Falchetti, E, Lanzillo, T, Caccavale, A, Bongo, A, Rizzi, A, Favilli, R, Maffei, S, Mallardo, M, Fulgione, C, Bordin, F, Bonmassari, R, Battaia, E, Puzzo, A, Vianello, G, D'Arpino, A, Romei, M, Pajes, G, Petronzelli, S, Ghezzi, F, Brigido, S, Pignatelli, L, Brscic, E, Sori, P, Russo, M, Biancolillo, E, Ignone, G, De Giorgio, N, Campaniello, C, Ponticelli, P, Margonato, A, Gerosa, S, Cutaia, A, Casalicchio, C, Bartolomucci, F, Larosa, C, Spadafina, T, Putignano, A, Se Cristofaro, R, Bernardi, L, Sommariva, L, Celestini, A, Bertucci, C, Marchetti, M, Franceschini Grisolia, E, Ammendolea, C, Carini, M, Scipione, P, Politano, M, Rubino, G, Reina, C, Peccerillo, N, Paloscia, L, D'Alleva, A, Petacchi, R, Pignalosa, M, Lucchetti, D, Di Palma, F, La Mastra, R, Amico, A, De Filippis, M, Fontanella, B, Zanini, G, Casolo, G, Del Meglio, J, Parato, V, Genovesi, E, D'Alimonte, A, Miglioranza, A, Alessandri, N, Moscariello, F, Mauro, C, Sasso, A, Caso, P, Petrillo, C, Napoletano, C, Paparoni, S, Bernardo, V, Serdoz, R, Rotunno, R, Oppo, I, Aloisio, A, Aurelio, A, Licciardello, G, Cassaniti, L, Francese, G, Marcassa, C, Temporelli, P, Villani, R, Zorzoli, F, Mileto, F, De Vecchis, M, Scolozzi, D, Lupi, G, Caruso, D, Rebulla, E, La Fata, B, Anselmi, M, Girardi, P, Borruso, E, Ferrantelli, G, Sassone, B, Bressan, S, Capriolo, M, Pelissero, E, Piancastelli, M, Gobbi, M, Cocco, F, Bruno, M, Berti, S, Lo Surdo, G, Tanzi, P, De Rosa, R, Vilei, E, De Iaco, M, Grassi, G, Zanella, C, Marullo, L, Alfano, G, Pelaggi, P, Talarico, R, Tuccillo, B, Irace, L, Proietti, F, Di Croce, G, Di Lorenzo, L, Zarrilli, A, Bongini, M, Ranise, A, Aprile, A, Fornengo, C, Capogrosso, V, Tranghese, A, Golia, B, Marziano, A, Roncon, L, Picariello, C, Bagni, E, Leci, E, Gregorio, G, Gatto, F, Piemonte, F, Gervasio, F, Navazio, A, Guerri, E, Belmonte, E, Marino, F, Di Belardino, N, Di Nuzzo, M, Epifani, M, Comolatti, G, Conconi, B, Benea, D, Casu, G, Merella, P, Ammirati, M, Corrado, V, Spagnolo, D, Caico, S, Bonizzato, S, Margheri, M, Corrado, L, Antonicelli, R, Ferrigno, C, Merlino, A, Nassiacos, D, Antonelli, A, Marchese, A, Villella, A, Bechi, S, Lo Bianco, F, Bedogni, F, Negro, L, Donato, L, Statile, D, Cassin, M, Fedele, F, Granatelli, A, Calcagno, S, Politi, A, and Pani, A

Subjects
medicine.medical_specialty, animal structures, Population, Myocardial Infarction, Coronary artery disease, Rivaroxaban, Internal medicine, Epidemiology, medicine, Humans, Registries, Myocardial infarction, education, Stroke, education.field_of_study, Aspirin, business.industry, Health Policy, Incidence (epidemiology), medicine.disease, COMPASS trial, Cohort, Cardiology and Cardiovascular Medicine, business, START registry, Mace
Abstract

Aims Recently, the cardiovascular outcomes for people using anticoagulation strategies (COMPASS) trial demonstrated that dual therapy reduced cardiovascular outcomes compared with aspirin alone in patients with stable atherosclerotic disease. Methods and results We sought to assess the proportion of patients eligible for the COMPASS trial and to compare the epidemiology and outcome of these patients with those without COMPASS inclusion or with any exclusion criteria in a contemporary, nationwide cohort of patients with stable coronary artery disease. Among the 4068 patients with detailed information allowing evaluation of eligibility, 1416 (34.8%) did not fulfil the inclusion criteria (COMPASS-Not-Included), 841 (20.7%) had exclusion criteria (COMPASS-Excluded), and the remaining 1811 (44.5%) were classified as COMPASS-Like. At 1 year, the incidence of major adverse cardiovascular event (MACE), a composite of cardiovascular death, myocardial infarction, and stroke, was 0.9% in the COMPASS-Not-Included and 2.0% in the COMPASS-Like (P = 0.01), and 5.0% in the COMPASS-Excluded group (P Conclusion In a contemporary real-world cohort registry of stable coronary artery disease, most patients resulted as eligible for the COMPASS. These patients presented a considerable annual risk of MACE that consistently increases in the presence of multiple risk factors.

Published
2021

38. Clinical outcomes, pharmacological treatment, and quality of life of patients with stable coronary artery diseases managed by cardiologists: 1-year results of the START study

Author

De Luca, L., Temporelli, P. L., Riccio, C., Gonzini, L., Marinacci, L., Tartaglione, S. N., Costa, P., Scherillo, M., Senni, M., Colivicchi, F., Gulizia, M. M., Rehih, K., Vicchi, C., Amico, A. F., Formigli, D., Geraci, G., Di Lenarda, A., Zia, X., Maggioni, A. P., Lucci, D., Lorimer, A., Orsini, G., Fabbri, G., Priami, P., Maras, P., Ramani, F., Falcone, C., Passarelli, I., Mauri, S., Calabro, P., Bianchi, R., Di Palma, G., Anna, S., Sebastiano, S., Mascia, F., Vetrano, A., Fusco, A., Proia, E., Aiello, A., Tomai, F., Licitra, R., Petrolini, A., Bosco, B., Fazzi, V., Magliari, F., Callerame, M., Mazzella, T., Lettica, G. V., Coco, G., Incao, F., D'Addario, S., Ubaldi, S., Sanchez, F. A., Manca, G., Failla, M., Procaccini, V., Luminita, E. M., Bonomo, P., Mossa, C., Corda, S., Colavita, A. R., Trevisonno, G., Vizzari, G., Cosentino, N., Formaro, C., Paolillo, C., Nalin, I. L., De Rosa, F. M., Fontana, F., Fuscaldo, G. F., Passamonti, E., Bertella, E., Calvaruso, E. V., Varani, E., Tani, F., Cicchitelli, G., Gabrielli, D., Paoloni, P., Marziali, A., Campo, G., Tebaldi, M., Biscaglia, S., Di Biase, M., Brunetti, N. D., Gallotta, A. M., Mattei, L., Marini, R., Balsemin, F., D'Urbano, M., Naio, R., Vicinelli, P., Arena, G., Mazzini, M., Gigli, N., Miserrafiti, B., Monopoli, A., Mortara, A., Delfino, P., Chioffi, M. M., Marino, P., Gravellone, M., Barbieri, L., Ledda, A., Carmina, M. G., Raisaro, A. E., Di Giacomo, C., Somaschini, A., Fasano, M. L., Sannazzaro, M., Arcieri, R., Pantaleoni, M., Leuzzi, C., Gorlato, G., Greco, G., Chiera, A., Ammaturo, T. A., Malanchini, G., Del Corral, M. P., Tedesco, L., Pede, S., Urso, L. G., Piscione, F., Galasso, G., Provasoli, S., Fattore, L., Lucca, G., Cresti, A., Cardillo, A., Fera, M. S., Vennettilli, F., Gaudio, C., Paravati, V., Caldarola, P., Locuratolo, N., Verlato, R., De Conti, F., Turiano, G., Preti, G., Moretti, L., Silenzi, S., Colonna, G., Picciolo, A., Nicosia, A., Cascone, C., Di Sciascio, G., Mangiacapra, F., Russo, A., Villella, M., Esposito, G., Cosmi, F., D'Orazio, S., Costantini, C., Lanari, A., De Rosa, P., Esposito, L., Bilato, C., Dalla Valle, C., Ceresa, M., Colombo, E., Pennisi, V., Casciola, G., Driussi, M., Bisceglia, T., Scalvini, S., Rivadossi, F., Volpe, M., Comito, F., Scorzoni, D., Grimoldi, P., Lagioia, R., Santoro, D., De Cesare, N., Comotti, T., Poli, A., Martina, P., Musolino, M. F., Multari, E. I., Bilardo, G., Scalchi, G., Olivieri, C., Caranci, F., Pavan, D., Ganci, G., Mariani, A., Falchetti, E., Lanzillo, T., Caccavale, A., Bongo, A. S., Rizzi, A., Favilli, R., Maffei, S., Mallardo, M., Fulgione, C., Bordin, F., Bonmassari, R., Battaia, E., Puzzo, A., Vianello, G., D'Arpino, A., Romei, M., Pajes, G., Petronzelli, S., Ghezzi, F., Brigido, S., Pignatelli, L., Brscic, E., Sori, P., Russo, M., Biancolillo, E., Ignone, G., De Giorgio, N. A., Campaniello, C., Ponticelli, P., Margonato, A., Gerosa, S., Cutaia, A., Casalicchio, C., Bartolomucci, F., Larosa, C., Spadafina, T., Putignano, A., De Cristofaro, R., Bernardi, L., Sommariva, L., Celestini, A., Bertucci, C. M., Marchetti, M., Grisolia, E. F., Ammendolea, C., Carini, M., Scipione, P., Politano, M., Rubino, G., Reina, C., Peccerillo, N., Paloscia, L., D'Alleva, A., Petacchi, R., Pignalosa, M., Lucchetti, D., Di Palma, F., La Mastra, R. A., De Filippis, M., Fontanella, B., Zanini, G., Casolo, G., Del Meglio, J., Parato, V. M., Genovesi, E., D'Alimonte, A., Miglioranza, A., Alessandri, N., Moscariello, F., Mauro, C., Sasso, A., Caso, P., Petrillo, C., Napoletano, C., Paparoni, S. R., Bernardo, V., Serdoz, R., Rotunno, R., Oppo, I., Aloisio, A., Aurelio, A., Licciardello, G., Cassaniti, L., Francese, G. M., Marcassa, C., Villani, R., Zorzoli, F., Mileto, F., De Vecchis, M., Scolozzi, D., Lupi, G., Caruso, D., Rebulla, E., Fata, B. L., Anselmi, M., Girardi, P., Borruso, E., Ferrantelli, G., Sassone, B., Bressan, S., Capriolo, M., Pelissero, E., Piancastelli, M., Gobbi, M., Cocco, F., Bruno, M. G., Berti, S., Surdo, G. L., Tanzi, P., De Rosa, R., Vilei, E., De Iaco, M. R., Grassi, G., Zanella, C., Marullo, L., Alfano, G., Pelaggi, P., Talarico, R., Tuccillo, B., Irace, L., Di Lorenzo, L., Zarrilli, A., Bongini, M., Ranise, A., Aprile, A., Fornengo, C., Capogrosso, V., Tranghese, A., Golia, B., Marziano, A., Roncon, L., Picariello, C., Bagni, E., Leci, E., Gregorio, G., Gatto, F., Piemonte, F., Puzio, E., Navazio, A., Guerri, E., Belmonte, E., Marino, F., Di Belardino, N., Di Nuzzo, M. R., Epifani, M., Comolatti, G., Conconi, B., Benea, D., Casu, G., Merella, P., Ammirati, M. A., Corrado, V. M., Spagnolo, D., Caico, S. I., Bonizzato, S., Margheri, M., Corrado, L., Antonicelli, R., Ferrigno, C., Merlino, A., Nassiacos, D., Antonelli, A., Marchese, A., Uguccioni, M., Villella, A., Bechi, S., Bianco, F. L., Bedogni, F., Negro, L., Donato, L., Statile, D., Cassin, M., Fedele, F., Granatelli, A., Calcagno, S., Politi, A., Pani, A., De Luca, L., Temporelli, P. L., Riccio, C., Gonzini, L., Marinacci, L., Tartaglione, S. N., Costa, P., Scherillo, M., Senni, M., Colivicchi, F., Gulizia, M. M., Amico, A. F., Formigli, D., Geraci, G., Di Lenarda, A., Maggioni, A. P., Lucci, D., Lorimer, A., Orsini, G., Fabbri, G., Priami, P., Maras, P., Ramani, F., Falcone, C., Passarelli, I., Mauri, S., Calabro, P., Bianchi, R., Di Palma, G., Anna, S., Sebastiano, S., Mascia, F., Vetrano, A., Fusco, A., Proia, E., Aiello, A., Tomai, F., Licitra, R., Petrolini, A., Bosco, B., Fazzi, V., Magliari, F., Callerame, M., Mazzella, T., Lettica, G. V., Coco, G., Incao, F., D'Addario, S., Ubaldi, S., Sanchez, F. A., Manca, G., Failla, M., Procaccini, V., Luminita, E. M., Bonomo, P., Mossa, C., Corda, S., Colavita, A. R., Trevisonno, G., Vizzari, G., Cosentino, N., Formaro, C., Paolillo, C., Nalin, I. L., De Rosa, F. M., Fontana, F., Fuscaldo, G. F., Passamonti, E., Bertella, E., Calvaruso, E. V., Varani, E., Tani, F., Cicchitelli, G., Gabrielli, D., Paoloni, P., Marziali, A., Campo, G., Tebaldi, M., Biscaglia, S., Di Biase, M., Brunetti, N. D., Gallotta, A. M., Mattei, L., Marini, R., Balsemin, F., D'Urbano, M., Naio, R., Vicinelli, P., Arena, G., Mazzini, M., Gigli, N., Miserrafiti, B., Monopoli, A., Mortara, A., Delfino, P., Chioffi, M. M., Marino, P., Gravellone, M., Barbieri, L., Ledda, A., Carmina, M. G., Raisaro, A. E., Di Giacomo, C., Somaschini, A., Fasano, M. L., Sannazzaro, M., Arcieri, R., Pantaleoni, M., Leuzzi, C., Gorlato, G., Greco, G., Chiera, A., Ammaturo, T. A., Malanchini, G., Del Corral, M. P., Tedesco, L., Pede, S., Urso, L. G., Piscione, F., Galasso, G., Provasoli, S., Fattore, L., Lucca, G., Cresti, A., Cardillo, A., Fera, M. S., Vennettilli, F., Gaudio, C., Paravati, V., Caldarola, P., Locuratolo, N., Verlato, R., De Conti, F., Turiano, G., Preti, G., Moretti, L., Silenzi, S., Colonna, G., Picciolo, A., Nicosia, A., Cascone, C., Di Sciascio, G., Mangiacapra, F., Russo, A., Villella, M., Esposito, G., Cosmi, F., D'Orazio, S., Costantini, C., Lanari, A., De Rosa, P., Esposito, L., Bilato, C., Dalla Valle, C., Ceresa, M., Colombo, E., Pennisi, V., Casciola, G., Driussi, M., Bisceglia, T., Scalvini, S., Rivadossi, F., Volpe, M., Comito, F., Scorzoni, D., Grimoldi, P., Lagioia, R., Santoro, D., De Cesare, N., Comotti, T., Poli, A., Martina, P., Musolino, M. F., Multari, E. I., Bilardo, G., Scalchi, G., Olivieri, C., Caranci, F., Pavan, D., Ganci, G., Mariani, A., Falchetti, E., Lanzillo, T., Caccavale, A., Bongo, A. S., Rizzi, A., Favilli, R., Maffei, S., Mallardo, M., Fulgione, C., Bordin, F., Bonmassari, R., Battaia, E., Puzzo, A., Vianello, G., D'Arpino, A., Romei, M., Pajes, G., Petronzelli, S., Ghezzi, F., Brigido, S., Pignatelli, L., Brscic, E., Sori, P., Russo, M., Biancolillo, E., Ignone, G., De Giorgio, N. A., Campaniello, C., Ponticelli, P., Margonato, A., Gerosa, S., Cutaia, A., Casalicchio, C., Bartolomucci, F., Larosa, C., Spadafina, T., Putignano, A., De Cristofaro, R., Bernardi, L., Sommariva, L., Celestini, A., Bertucci, C. M., Marchetti, M., Grisolia, E. F., Ammendolea, C., Carini, M., Scipione, P., Politano, M., Rubino, G., Reina, C., Peccerillo, N., Paloscia, L., D'Alleva, A., Petacchi, R., Pignalosa, M., Lucchetti, D., Di Palma, F., La Mastra, R. A., De Filippis, M., Fontanella, B., Zanini, G., Casolo, G., Del Meglio, J., Parato, V. M., Genovesi, E., D'Alimonte, A., Miglioranza, A., Alessandri, N., Moscariello, F., Mauro, C., Sasso, A., Caso, P., Petrillo, C., Napoletano, C., Paparoni, S. R., Bernardo, V., Serdoz, R., Rotunno, R., Oppo, I., Aloisio, A., Aurelio, A., Licciardello, G., Cassaniti, L., Francese, G. M., Marcassa, C., Villani, R., Zorzoli, F., Mileto, F., De Vecchis, M., Scolozzi, D., Lupi, G., Caruso, D., Rebulla, E., Fata, B. L., Anselmi, M., Girardi, P., Borruso, E., Ferrantelli, G., Sassone, B., Bressan, S., Capriolo, M., Pelissero, E., Piancastelli, M., Gobbi, M., Cocco, F., Bruno, M. G., Berti, S., Surdo, G. L., Tanzi, P., De Rosa, R., Vilei, E., De Iaco, M. R., Grassi, G., Zanella, C., Marullo, L., Alfano, G., Pelaggi, P., Talarico, R., Tuccillo, B., Irace, L., Di Lorenzo, L., Zarrilli, A., Bongini, M., Ranise, A., Aprile, A., Fornengo, C., Capogrosso, V., Tranghese, A., Golia, B., Marziano, A., Roncon, L., Picariello, C., Bagni, E., Leci, E., Gregorio, G., Gatto, F., Piemonte, F., Puzio, E., Navazio, A., Guerri, E., Belmonte, E., Marino, F., Di Belardino, N., Di Nuzzo, M. R., Epifani, M., Comolatti, G., Conconi, B., Benea, D., Casu, G., Merella, P., Ammirati, M. A., Corrado, V. M., Spagnolo, D., Caico, S. I., Bonizzato, S., Margheri, M., Corrado, L., Antonicelli, R., Ferrigno, C., Merlino, A., Nassiacos, D., Antonelli, A., Marchese, A., Uguccioni, M., Villella, A., Bechi, S., Bianco, F. L., Bedogni, F., Negro, L., Donato, L., Statile, D., Cassin, M., Fedele, F., Granatelli, A., Calcagno, S., Politi, A., Pani, A., Vicchi, C., Zia, X., De Luca, L, Temporelli, P, Riccio, C, Gonzini, L, Marinacci, L, Tartaglione, S, Costa, P, Scherillo, M, Senni, M, Colivicchi, F, Gulizia, M, and Start, I

Subjects
Registrie, Quality of life, Male, medicine.medical_specialty, Outcome, Quality of life, Stable coronary artery disease, Treatment, Aged, Cardiology, Coronary Artery Disease, Prospective Studies, Registries, Time Factors, Time Factors, Time Factor, Cardiology, Coronary Artery Disease, NO, Coronary artery disease, angina, Pharmacotherapy, Internal medicine, medicine, Humans, adherence, guidelines, Prospective Studies, Registries, outcome keywords plus:focused update, Cause of death, Outcome, Aged, therapy, treatment, business.industry, Health Policy, association, Odds ratio, Middle Aged, medicine.disease, mortality, Confidence interval, stable coronary artery disease, quality of life, outpatients, Treatment, Prospective Studie, Treatment Outcome, Cohort, Observational study, Stable coronary artery disease, Female, Cardiology and Cardiovascular Medicine, business, Human
Abstract

Aims We evaluated the 1-year clinical events, pharmacological management, and quality of life in a contemporary cohort of stable coronary artery disease (CAD) patients managed by cardiologists. Methods and results START (STable Coronary Artery Diseases RegisTry) was a prospective, observational, nationwide study that enrolled 5070 stable CAD patients over 3 months in 183 cardiology centres in Italy. At 1 year, 4790 (94.5%) patients had data on vital status. Death occurred in 107 (2.2%) patients and the cause of death was cardiovascular in 41 (38.3%) of cases. Among the 4775 patients with follow-up data on clinical events available, a hospitalization due to cardiovascular and non-cardiovascular causes occurred in 523 (11.0%) and in 231 (4.8%) of cases, respectively. Over 60% of patients reported as ‘no problems’ in all domains (61.4–84.5%) of the EuroQoL quality of life 5D-5L questionnaire. Among the 3239 patients with clinical visit/telephone interview at follow-up, in whom optimal medical therapy (OMT; aspirin or thienopyridine, β-blocker, and statin) was prescribed at enrolment, 2971 (91.7%) were still receiving OMT at follow-up. At multivariable analysis, only increasing age (odds ratio 0.98; 95% confidence interval 0.97–0.99; P = 0.04) resulted as independent negative predictor of OMT persistence at 1 year from enrolment. Conclusion In this large, contemporary registry, stable CAD patients managed by cardiologists presented a high rate of clinical events at 1 year. Nevertheless, the persistence to OMT and quality of life appeared reasonable.

Published
2019

40. Prognostic significance of serum uric acid in outpatients with chronic heart failure is complex and related to body mass index: Data from the IN-CHF Registry

Author

Baldasseroni, S, Urso, R, Maggioni, Ap, Orso, F, Fabbri, G, Marchionni, N, Tavazzi, L, the IN CHF Investigators: Mezzani, A, Bielli, M, Milanese, G, Ugliengo, G, Pozzi, R, Rabajoli, F, Bosimini, E, Begliuomini, G, Ferrari, A, Barzizza, F, Valsecchi, F, Dadda, F, Faggiano, P, Castiglioni, G, Gibelli, G, Turelli, Al, Belluschi, R, Bianchi, C, Emanuelli, C, Gramenzi, S, Foti, S, Agnelli, D, Mascioli, G, Cazzani, E, Zanelli, E, Domenighini, D, Castelli, C, Moroni, E, Gara, E, Guzzetti, S, Muzzupappa, S, Turiel, M, Cappiello, E, Sandrone, G, Recalcati, F, Valenti, D, Achilli, F, Vincenzi, A, Rusconi, F, Palvarini, M, Ghio, S, Fontana, A, Giusti, A, Scelsi, L, Sebastiani, R, Ceresa, M, Nassiacos, D, Meloni, S, Nicoli, T, Bandini, P, Pedretti, R, Paolucci, M, Amati, L, Ravetta, M, Morandi, F, Provasoli, S, Bertolini, A, Imperiale, D, Agen, W, Planca, E, Quorso, P, Ferro, A, Pedrolli, C, Russo, P, Tarantini, L, Candelpergher, G, Cannarozzo, Pp, De Cian, F, Agnoli, A, Stefanini, Mg, Cacciavillani, L, Boffa, Gm, Mario, L, Renosto, G, Stritoni, P, Varotto, L, Penzo, M, Perini, G, Giuliano, G, Barducci, E, Piazza, R, Albanese, Mc, Fresco, C, Picco, F, Venturini, P, Camerini, A, Griffo, R, Derchi, G, Delfino, L, Pizzorno, L, Mazzantini, S, Torre, F, Orlandi, S, Bertoli, D, Gentile, A, Naccarella, F, Gatti, M, Coluccini, M, Morgagni, G, Alfano, G, Reggianini, L, Sansoni, S, Serra, W, Passerini, F, Del Corso, P, Rusconi, L, Marzaloni, M, Mezzetti, M, Gambarati, Gp, Mariani, Pr, Volterrani, C, Venturi, F, Zambald, G, Casolo, G, Moschi, G, Geri Brandinelli, A, Miracapillo, G, Boni, A, Italiani, G, Vergoni, W, Paci, Am, Lattanzi, F, Reisenhofer, B, Severini, D, Taddei, T, Dalle Luche, A, Comella, A, Gasperini, U, Cocchieri, M, Alunni, G, Bosi, E, Panciarola, R, Maragoni, G, Bardelli, G, Testarmata, P, Pasetti, L, Budini, A, Gabrilelli, D, Coderoni, B, Midi, P, Romaniello, C, Del Sindaco, D, Leggio, F, Terranova, A, Pulignano, G, Pozzar, F, Ansalone, G, Magris, B, Giannantoni, P, Cacciatore, G, Bottero, G, Scaffidi, G, Valtorta, C, Salustri, A, Amadeo, F, Barbato, G, Aspromonte, N, Baldo, V, Baldo, E, Frattaroli, C, Mariani, A, Di Marco, G, Levantesi, G, Potena, Ap, Colonna, N, Montano, A, Sensale, P, Maiolica, O, Somelli, A, Napolitano, F, Provvisiero, P, Bottiglieri, P, Ciriello, N, Angelini, E, Andriulo, C, De Santis, F, Cocco, F, Zecca, A, Pennetta, A, Mariello, F, Magliari, F, De Giorgi, A, Callerame, M, Santoro, V, Pede, S, Renna, A, De Donno, O, De Lorenzi, E, Polimeni, G, Russo, Va, Mangia, R, Truncellito, L, Cariello, Fp, Affinita, M, Perticone, F, Cloro, C, Borelli, D, Matta, M, Lopresti, D, Misuraca, G, Caporale, R, Chiappetta, P, Tripodi, E, Tassone, F, Salituri, S, Errigo, C, Meringolo, G, Donnangelo, L, Canonico, G, Coco, R, Franco, M, Coglitore, A, Donato, A, Di Tano, G, Cento, Domenico, DE GREGORIO, Cesare, Mongiovı, M, Schillaci, Am, Mirto, Ij, Clemenza, F, Ingrillı, F, Cavallaro, A, Aloisi, B, Ledda, G, Rizzo, C, Porcu, M, Salis, S, Pistis, L, Pili, G, Piras, S, Maoddi, I, and Uras, F.

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Hyperuricemia, Models, Biological, Severity of Illness Index, Body Mass Index, chemistry.chemical_compound, Thinness, Internal medicine, Severity of illness, Ambulatory Care, Humans, Medicine, Registries, Mortality, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, Heart Failure, Nutrition and Dietetics, business.industry, Hazard ratio, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Confidence interval, Uric Acid, Surgery, Italy, chemistry, Heart failure, Cardiology, Uric acid, Female, Cardiology and Cardiovascular Medicine, business, Body mass index
Abstract

In the field of cardiovascular diseases, elevated levels of serum uric acid (UA) reflect a marked activation of the xanthine oxidase pathway with increase in free radicals production; it is often associated with an inflammatory state, oxygen consumption and endothelial dysfunction. All these associations have been also confirmed in heart failure (HF) but the pathophysiological role of UA in this setting is not well understood. The aim of this study was to evaluate the prognostic role of UA in outpatients enrolled in the Italian Registry of Congestive Heart Failure (IN-CHF).All patients met the European Society of Cardiology (ESC) criteria for diagnosis of HF. We considered patients with complete clinical data and UA level available at the baseline and at 1-year follow-up. The study population was composed of 877 patients aged 63 ± 12 years. One-year mortality was 10.8% and dead patients had a higher level of UA than survivors (7.1 mg dl⁻¹ vs 6.6 mg dl⁻¹, p0.0207). In multivariable full model of analysis, UA did not result in an independent predictor of death in overall population, but only in patients with low body mass index (BMI) (≤22 kg m⁻²) (hazard ratio (HR): 2.38, 95% confidence interval (CI) 1.36-4.18). In this subgroup, a statistically significant gradual relationship between UA and survival was detected starting from values higher than 8 mg dl⁻¹.Elevated level of UA is not an independent predictor of mortality in chronic HF, but it markedly worsens outcome if associated with low level of BMI. This association is likely an indicator of chronic inflammatory and catabolic state.

Published
2012
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41. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial

Author

Trimarco, THE TELMISARTAN RANDOMISED ASSESSMENT STUDY IN ACE INTOLERANT SUBJECTS WITH CARDIOVASCULAR DISEASE TRANSCEND INVESTIGATORS Italy: B., Verdecchia, P., Maggioni, A., Achilli, A., Agabiti Rosei, E., Ambrosio, Gb, Bentivoglio, M., Branzi, A., Chersevani, D., Chiariello, M., Cirrincione, V., Dembech, C., Ferrari, R., Gattobigio, R., Giovannini, E., Lauro, R., Lembo, Giuseppe, Moretti, L., Pancaldi, L., Pede, S., Pettinati, G., Reboldi, G., Ricci, R., Rosiello, G., Rozza, F., Sardone, Mg, Tavazzi, L., Terrosu, P., Venco, A., Vetrano, A., and Volpe, Massimo

Subjects
Male, medicine.medical_specialty, Angiotensin-Converting Enzyme Inhibitors, Kaplan-Meier Estimate, Klinikai orvostudományok, Placebo, Benzoates, law.invention, Randomized controlled trial, law, Internal medicine, medicine, Humans, Single-Blind Method, Telmisartan, Myocardial infarction, Angioedema, Stroke, Aged, Intention-to-treat analysis, biology, business.industry, Angiotensin-converting enzyme, Orvostudományok, General Medicine, medicine.disease, ACE inibitori, AT1 bloccanti, trial clinico, Candesartan, Cough, Therapeutic Equivalency, Cardiovascular Diseases, Anesthesia, biology.protein, Benzimidazoles, Female, Hypotension, business, Risk Reduction Behavior, Follow-Up Studies, medicine.drug
Abstract

BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors reduce major cardiovascular events, but are not tolerated by about 20% of patients. We therefore assessed whether the angiotensin-receptor blocker telmisartan would be effective in patients intolerant to ACE inhibitors with cardiovascular disease or diabetes with end-organ damage. METHODS: After a 3-week run-in period, 5926 patients, many of whom were receiving concomitant proven therapies, were randomised to receive telmisartan 80 mg/day (n=2954) or placebo (n=2972) by use of a central automated randomisation system. Randomisation was stratified by hospital. The primary outcome was the composite of cardiovascular death, myocardial infarction, stroke, or hospitalisation for heart failure. Analyses were done by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00153101. FINDINGS: The median duration of follow-up was 56 (IQR 51-64) months. All randomised patients were included in the efficacy analyses. Mean blood pressure was lower in the telmisartan group than in the placebo group throughout the study (weighted mean difference between groups 4.0/2.2 [SD 19.6/12.0] mm Hg). 465 (15.7%) patients experienced the primary outcome in the telmisartan group compared with 504 (17.0%) in the placebo group (hazard ratio 0.92, 95% CI 0.81-1.05, p=0.216). One of the secondary outcomes-a composite of cardiovascular death, myocardial infarction, or stroke-occurred in 384 (13.0%) patients on telmisartan compared with 440 (14.8%) on placebo (0.87, 0.76-1.00, p=0.048 unadjusted; p=0.068 after adjustment for multiplicity of comparisons and overlap with primary outcome). 894 (30.3%) patients receiving telmisartan were hospitalised for a cardiovascular reason, compared with 980 (33.0%) on placebo (relative risk 0.92, 95% CI 0.85-0.99; p=0.025). Fewer patients permanently discontinued study medication in the telmisartan group than in the placebo group (639 [21.6%] vs 705 [23.8%]; p=0.055); the most common reason for permanent discontinuation was hypotensive symptoms (29 [0.98%] in the telmisartan group vs 16 [0.54%] in the placebo group). INTERPRETATION: Telmisartan was well tolerated in patients unable to tolerate ACE inhibitors. Although the drug had no significant effect on the primary outcome of this study, which included hospitalisations for heart failure, it modestly reduced the risk of the composite outcome of cardiovascular death, myocardial infarction, or stroke. FUNDING: Boehringer Ingelheim.

Published
2008
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42. Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post‐Hoc Analysis of the GISSI‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) Trial

Author

Dauriz, Marco, primary, Targher, Giovanni, additional, Temporelli, Pier Luigi, additional, Lucci, Donata, additional, Gonzini, Lucio, additional, Nicolosi, Gian Luigi, additional, Marchioli, Roberto, additional, Tognoni, Gianni, additional, Latini, Roberto, additional, Cosmi, Franco, additional, Tavazzi, Luigi, additional, Maggioni, Aldo Pietro, additional, Barlera, Simona, additional, Franzosi, Maria Grazia, additional, Maggioni, Aldo P., additional, Porcu, Maurizio, additional, Yusuf, Salim, additional, Camerini, Fulvio, additional, Cohn, Jay N., additional, Decarli, Adriano, additional, Pitt, Bertram, additional, Sleight, Peter, additional, Poole‐Wilson, Philip A., additional, Geraci, Enrico, additional, Scherillo, Marino, additional, Fabbri, Gianna, additional, Bartolomei, Barbara, additional, Bertoli, Daniele, additional, Cobelli, Franco, additional, Fresco, Claudio, additional, Ledda, Antonietta, additional, Levantesi, Giacomo, additional, Opasich, Cristina, additional, Rusconi, Franco, additional, Sinagra, Gianfranco, additional, Turazza, Fabio, additional, Volpi, Alberto, additional, Ceseri, Martina, additional, Alongi, Gianluca, additional, Atzori, Antonio, additional, Bambi, Filippo, additional, Bastarolo, Desiree, additional, Bianchini, Francesca, additional, Cangioli, Iacopo, additional, Canu, Vittoriana, additional, Caporusso, Concetta, additional, Cenni, Gabriele, additional, Cintelli, Laura, additional, Cocchio, Michele, additional, Confente, Alessia, additional, Fenicia, Eva, additional, Friso, Giorgio, additional, Gianfriddo, Marco, additional, Grilli, Gianluca, additional, Lazzaro, Beatrice, additional, Lonardo, Giuseppe, additional, Luise, Alessia, additional, Nota, Rachele, additional, Orlando, Mariaelena, additional, Petrolo, Rosaria, additional, Pierattini, Chiara, additional, Pierota, Valeria, additional, Provenzani, Alessandro, additional, Quartuccio, Velia, additional, Ragno, Anna, additional, Serio, Chiara, additional, Spolaor, Alvise, additional, Tafi, Arianna, additional, Tellaroli, Elisa, additional, Ghio, Stefano, additional, Ghizzardi, Elisa, additional, Masson, Serge, additional, Crociati, Lella, additional, La Rovere, Maria Teresa, additional, Corrà, Ugo, additional, Finzi, Andrea, additional, Gorini, Marco, additional, Milani, Valentina, additional, Orsini, Giampietro, additional, Bianchini, Elisa, additional, Cabiddu, Silvia, additional, Cangioli, Ilaria, additional, Cipressa, Laura, additional, Cipressa, Maria Lucia, additional, Di Bitetto, Giuseppina, additional, Ferri, Barbara, additional, Galbiati, Luisa, additional, Lorimer, Andrea, additional, Pera, Carla, additional, Priami, Paola, additional, Vasamì, Antonella, additional, Moccetti, T., additional, Rossi, M.G., additional, Pasotti, E., additional, Vaghi, F., additional, Roncarolo, P., additional, Zunino, M.T., additional, Matta, F., additional, Perinetto, E. Actis, additional, Gaita, F., additional, Azzaro, G., additional, Zanetta, M., additional, Paino, A.M., additional, Parravicini, U., additional, Vegis, D., additional, Conte, R., additional, Ferraro, P., additional, De Bernardi, A., additional, Morelloni, S., additional, Fagnani, M., additional, Lucchina, P. Greco, additional, Montagna, L., additional, Bellone, E., additional, Sappè, D., additional, Ferraro, F., additional, Delucchi, M., additional, Reynaud, S.G., additional, Dore, M., additional, La Brocca, A., additional, Massobrio, N., additional, Bo, L., additional, Trinchero, R., additional, Imazio, M., additional, Brocchi, G., additional, Nejrotti, A., additional, Rissone, L., additional, Gabasio, S., additional, Zocchi, C., additional, Randazzo, S., additional, Crenna, A., additional, Giannuzzi, P., additional, Bonanomi, E., additional, Mezzani, A., additional, De Marchi, M., additional, Begliuomini, G., additional, Gianonatti, C.A., additional, Gavazzi, A., additional, Grosu, A., additional, Dei Cas, L., additional, Nodari, S., additional, Garyfallidis, P., additional, Bertoletti, A., additional, Bonifazi, C., additional, Arisi, S., additional, Mascaro, F., additional, Fraccarollo, M., additional, Dell'Orto, S., additional, Sfolcini, M., additional, Bortolini, F., additional, Raccagni, D., additional, Turelli, A., additional, Santarone, M., additional, Miglierina, E., additional, Sormani, L., additional, Jemoli, R., additional, Tettamanti, F., additional, Pirelli, S., additional, Bianchi, C., additional, Verde, S., additional, Mariani, M., additional, Ziacchi, V., additional, Ferrazza, A., additional, Russo, A., additional, Bortolotti, M., additional, Pasini, G.F., additional, Volpi, A., additional, Jones, K.N., additional, Cuzzucrea, D., additional, Gullace, G., additional, Carbone, C., additional, Granata, A., additional, De Servi, S., additional, Del Rosso, G., additional, Inserra, C., additional, Renaldini, E., additional, Zappa, C., additional, Moretti, M., additional, Zanini, R., additional, Ferrari, M., additional, Moroni, E., additional, Cei, A., additional, Lissi, C., additional, Dovico, E., additional, Fiorentini, C., additional, Palermo, P., additional, Brusoni, B., additional, Negrini, M., additional, Heyman, J., additional, Danzi, G.B., additional, Finzi, A., additional, Frigerio, M., additional, Turazza, F., additional, Beretta, L., additional, Sachero, A., additional, Casazza, F., additional, Squadroni, L., additional, Lombardi, F., additional, Marano, L., additional, Margonato, A., additional, Fragasso, G., additional, Febo, O.C., additional, Aiolfi, E., additional, Olmetti, F., additional, Grieco, A., additional, Antonazzo, V., additional, Specchia, G., additional, Mortara, A., additional, Robustelli, F., additional, Songini, M.G., additional, Schweiger, C., additional, Frisinghelli, A., additional, Palvarini, M., additional, Campana, C., additional, Scelsi, L., additional, Ajmone Marsan, N., additional, Cobelli, F., additional, Gualco, A., additional, Opasich, C., additional, De Feo, S., additional, Mazzucco, R., additional, Iannone, M.A., additional, Diaco, T., additional, Zaniboni, D., additional, Milanesi, G., additional, Nassiacos, D., additional, Meloni, S., additional, Giani, P., additional, Nicoli, T., additional, Malinverni, C., additional, Gusmini, A., additional, Pozzoni, L., additional, Bisiani, G., additional, Margaroli, P., additional, Schizzarotto, A., additional, Daverio, A., additional, Occhi, G., additional, Partesana, N., additional, Bandini, P., additional, Rosella, M.G., additional, Giustiniani, S., additional, Cucchi, G., additional, Pedretti, R., additional, Raimondo, R., additional, Vaninetti, R., additional, Fedele, A., additional, Ghezzi, I., additional, Rezzonico, E., additional, Salerno Uriarte, J.A., additional, Morandi, F., additional, Salvucci, F., additional, Valenti, C., additional, Graziano, G., additional, Romanò, M., additional, Cimminiello, C., additional, Mangone, I., additional, Lombardo, M., additional, Quorso, P., additional, Marinoni, G., additional, Breghi, M., additional, Erckert, M., additional, Dienstl, A., additional, Mirante Marini, G., additional, Stefenelli, C., additional, Cioffi, G., additional, Buczkowska, E., additional, Bonanome, A., additional, Bazzanini, F., additional, Parissenti, L., additional, Serafini, C., additional, Catania, G., additional, Tarantini, L., additional, Rigatelli, G., additional, Boni, S., additional, Pasini, A., additional, Masini, E., additional, Zampiero, A.A., additional, Zanchetta, M., additional, Franceschetto, L., additional, Delise, P., additional, Marcon, C., additional, Sacchetta, A., additional, Borgese, L., additional, Artusi, L., additional, Casolino, P., additional, Corbara, F., additional, Banzato, A., additional, Barbiero, M., additional, Aldegheri, M.P., additional, Bazzucco, R., additional, Crivellenti, G., additional, Raviele, A., additional, Zanella, C., additional, Pascotto, P., additional, Sarto, P., additional, Milan, S., additional, Barbieri, E., additional, Girardi, P., additional, Dalla Villa, W., additional, Dalle Mule, J., additional, Di Sipio, M.L., additional, Cazzin, R., additional, Milan, D., additional, Zonzin, P., additional, Carraro, M., additional, Rossi, R., additional, Carbonieri, E., additional, Rossi, I., additional, Stritoni, P., additional, Meneghetti, P., additional, Risica, G., additional, Tenderini, P.L., additional, Vassanelli, C., additional, Zanolla, L., additional, Perini, G., additional, Brighetti, G., additional, Chiozza, R., additional, Giuliano, G., additional, Gortan, R., additional, Cesanelli, R., additional, Nicolosi, G.L., additional, Piazza, R., additional, Mos, L., additional, Vriz, O., additional, Pavan, D., additional, Pascottini, G., additional, Alberti, E., additional, Werren, M., additional, Solinas, L., additional, Sinagra, G., additional, Longaro, F., additional, Fioretti, P., additional, Albanese, M.C., additional, Miani, D., additional, Gianrossi, R., additional, Pende, A., additional, Rubartelli, P., additional, Magaia, O., additional, Domenicucci, S., additional, Caruso, D., additional, Faraguti, A.S., additional, Magliani, L., additional, Miccoli, F., additional, Guglielmino, G., additional, Bertoli, D., additional, Cantarelli, A., additional, Orlandi, S., additional, Vallebona, A., additional, Pozzati, A., additional, Brega, G., additional, Pancaldi, L.G., additional, Vandelli, R., additional, Urbinati, S., additional, Poci, M.G., additional, Zoli, M., additional, Costa, G.M., additional, Guiducci, U., additional, Zobbi, G., additional, Tartagni, F., additional, Tisselli, A., additional, Gentili, A., additional, Pieri, P., additional, Cagnetta, E., additional, Bendinelli, S., additional, Barbieri, A., additional, Conti, R., additional, Ferrari, R., additional, Merlini, F., additional, Fucili, A., additional, Moruzzi, P., additional, Buia, E., additional, Galvani, M., additional, Ferrini, D., additional, Baggioni, G., additional, Yiannacopulu, P., additional, Canè, G., additional, Bonfiglioli, A., additional, Zandomeneghi, R., additional, Brugioni, L., additional, Giannini, A., additional, Di Ruvo, R., additional, Giuliani, M., additional, Rusconi, L., additional, Del Corso, P., additional, Piovaccari, G., additional, Bologna, F., additional, Venturi, P., additional, Melandri, F., additional, Bagni, E., additional, Bolognese, L., additional, Perticucci, R., additional, Zuppiroli, A., additional, Nannini, M., additional, Consoli, N., additional, Petrone, P., additional, Pipitò, C., additional, Colombi, L., additional, Bernardi, D., additional, Mariani, P.R., additional, Testa, R., additional, Mazzinghi, F., additional, Cosmi, F., additional, Cosmi, D., additional, Zipoli, A., additional, Cecchi, A., additional, Castelli, G., additional, Ciaccheri, M., additional, Mori, F., additional, Pieri, F., additional, Valoti, P., additional, Chiarantini, D., additional, Santoro, G.M., additional, Minneci, C., additional, Marchi, F., additional, Milli, M., additional, Zambaldi, G., additional, Brandinelli Geri, A.A., additional, Cipriani, M., additional, Alessandri, M., additional, Severi, S., additional, Stefanelli, S., additional, Comella, A., additional, Poddighe, R., additional, Digiorgio, A., additional, Carluccio, M., additional, Berti, S., additional, Rizza, A., additional, Bonatti, V., additional, Molendi, V., additional, Brancato, A., additional, D'Aprile, N., additional, Giappichini, G., additional, Del Vecchio, S., additional, Mantini, G., additional, De Tommasi, F., additional, Meucci, G., additional, Cordoni, M., additional, Bechi, S., additional, Barsotti, L., additional, Baldini, P., additional, Romei, M., additional, Scopelliti, G., additional, Lauri, G., additional, Pestelli, F., additional, Furiozzi, F., additional, Cocchieri, M., additional, Severini, D., additional, Patriarchi, F., additional, Chiocchi, P., additional, Buccolieri, M., additional, Martinelli, S., additional, Wee, A., additional, Angelici, F., additional, Bernardinangeli, M., additional, Proietti, G., additional, Biscottini, B., additional, Panciarola, R., additional, Marinacci, L., additional, Perna, G.P., additional, Gabrielli, D., additional, Moraca, A., additional, Moretti, L., additional, Partemi, L., additional, Gregori, G., additional, Amici, R., additional, Patteri, G., additional, Capone, P., additional, Savini, E., additional, Morgagni, G.L., additional, Paccaloni, L., additional, Pezzuoli, F., additional, Carincola, S., additional, Papi, S., additional, De Crescentini, S., additional, Gerardi, P., additional, Midi, P., additional, Gallenzi, E., additional, Pajes, G., additional, Mancone, C., additional, Di Spirito, V., additional, Di Gennaro, M., additional, Calcagno, S., additional, Toscano, S., additional, Antonicoli, S., additional, Carta, F., additional, Giorgi, G., additional, Comito, F., additional, Daniele, E., additional, Ciarla, O., additional, Gelfo, P.G., additional, Acquaviva, A., additional, Testa, D., additional, Testa, G., additional, Pagliaro, F.A., additional, Russo, F., additional, Vetta, F., additional, Marchese, I., additional, Di Sciascio, G., additional, D'Ambrosio, A., additional, Leggio, F., additional, Del Sindaco, D., additional, Lacchè, A., additional, Avallone, A., additional, Risa, M.P., additional, Azzolini, P., additional, Baldo, E., additional, Giovannini, E., additional, Pulignano, G., additional, Tondo, C., additional, Picchio, E., additional, ani, E., additional, Tanzi, P., additional, Pozzar, F., additional, Farnetti, F., additional, Azzarito, M., additional, Santini, M., additional, Varveri, A., additional, Ferraiuolo, G., additional, Valtorta, C., additional, Gaspardone, A., additional, Barbato, G., additional, Ceci, V., additional, Aspromonte, N., additional, Bellocci, F., additional, Colizzi, C., additional, Fedele, F., additional, Perez, F.I., additional, Galati, A., additional, Rossetti, A., additional, Mainella, A., additional, etta, D., additional, Matteucci, C., additional, Busi, G., additional, De Angelis, A., additional, Farina, G., additional, Granatelli, A., additional, Leone, F., additional, Frasca, F., additional, Di Giovambattista, R., additional, Castellani, G., additional, Massaro, G., additional, Mastrogiuseppe, G., additional, Vacri, A., additional, De Sanctis, F., additional, Cioli, M., additional, Di Luzio, S., additional, Napoletano, C., additional, Piccioni, L.L., additional, De Simone, G., additional, Ottaviano, A., additional, Mazza, V., additional, Spedaliere, C., additional, Staniscia, D., additional, Calgione, E., additional, De Marco, G., additional, Chiacchio, T., additional, Di Napoli, T., additional, Romanzi, S., additional, Salvatore, G., additional, Golino, P., additional, Palermo, A., additional, Mascia, F., additional, Vetrano, A., additional, Vinciguerra, A., additional, Caliendo, L., additional, Longobardi, R., additional, De Caro, G., additional, Di Nola, R., additional, Piemonte, F., additional, Prinzi, D., additional, De Rosa, P., additional, De Rosa, V., additional, Riello, F., additional, Capuano, V., additional, Vecchio, G., additional, Landi, M., additional, Amato, S., additional, Garofalo, M., additional, D'Avino, M., additional, Sensale, P., additional, Maiolica, O., additional, Santoro, R., additional, Caso, P., additional, Miceli, D., additional, Maurea, N., additional, Bianchi, U., additional, Crispo, C., additional, Chiariello, M., additional, Perrone Filardi, P., additional, Russo, L., additional, Capuano, N., additional, Ungaro, G., additional, Vergara, G., additional, Scafuro, F., additional, D'Angelo, G., additional, Campaniello, C., additional, Bottiglieri, P., additional, Volpe, A., additional, Battista, R., additional, De Risi, L., additional, Cardillo, G., additional, Sibilio, G., additional, Marino, A.P., additional, Silvestri, F., additional, Predotti, P., additional, Iervoglini, A., additional, De Matteis, C., additional, Sarnicola, P., additional, Matarazzo, M.M., additional, Baldi, S., additional, Iuliano, V., additional, Astarita, C., additional, Cuccaro, P., additional, Liguori, A., additional, Liguori, G., additional, Gregorio, G., additional, Petraglia, L., additional, Antonelli, G., additional, Amodio, G., additional, De Luca, I., additional, Traversa, D., additional, Franchini, G., additional, Lenti, M.L., additional, Cavallari, D., additional, D'Agostino, C., additional, Scalera, G., additional, Altamura, C.M., additional, Russo, M., additional, Mascolo, A.R., additional, Pettinati, G., additional, Ciricugno, S.A., additional, Scrutinio, D., additional, Passantino, A., additional, Mastrangelo, D., additional, Di Masi, A., additional, De Carne, R., additional, Cannone, M., additional, Dibiase, F., additional, Pensato, M., additional, Loliva, F., additional, Trapani, F., additional, Panettieri, I., additional, Leone, L., additional, Di Biase, M., additional, Carrone, M., additional, Gallone, V., additional, Cocco, F., additional, Costantini, M., additional, Tritto, C., additional, Cavalieri, F., additional, Stella, L., additional, Magliari, F., additional, Callerame, M., additional, De Giorgi, A., additional, Pellegrino, L., additional, Correra, M., additional, Portulano, V., additional, Nisi, G.L., additional, Grassi, G., additional, Cristallo, E., additional, De Laura, D., additional, Salerno, C., additional, Fanelli, R., additional, Villella, M., additional, Pede, S., additional, Renna, A., additional, De Lorenzi, E., additional, Urso, L., additional, Lenti, V., additional, Peluso, A., additional, Baldi, N., additional, Polimeni, G., additional, Palma, P., additional, Lauletta, R., additional, Tagliamonte, E., additional, Cirillo, T., additional, Silvestri, B., additional, Centonze, G., additional, D'Alessandro, B., additional, Truncellito, L., additional, Mecca, D., additional, Petruzzi, M.A., additional, Coviello, R.O.M., additional, Lopizzo, A., additional, telli, M., additional, Barbuzzi, S., additional, Gubelli, S., additional, Germinario, G., additional, Cosentino, N., additional, Mingrone, A., additional, Vico, R., additional, Borrello, G., additional, Mazza, M.L., additional, Cimino, R., additional, Galasso, D., additional, Cassadonte, F., additional, Talarico, U., additional, Perticone, F., additional, Cassano, S., additional, Catapano, F., additional, Calemme, S., additional, Feraco, E., additional, Cloro, C., additional, Misuraca, G., additional, Caporale, R., additional, Vigna, L., additional, Spagnuolo, V., additional, De Rosa, F., additional, Spadafora, G., additional, Zampaglione, G., additional, Russo, R., additional, Schipani, F.A., additional, Ferragina, A.F., additional, Stranieri, D., additional, Musca, G., additional, Carpino, C., additional, Bencardino, P., additional, Raimondo, F., additional, Musacchio, D., additional, Pulitanò, G., additional, Ruggeri, A., additional, Provenzano, A., additional, Salituri, S., additional, Musolino, M., additional, Calandruccio, S., additional, Marrari, A., additional, Tripodi, E., additional, Scali, R., additional, Anastasio, L., additional, Arone, A., additional, Aragona, P., additional, Donnangelo, L., additional, Comito, M.G.A., additional, Bilotta, F., additional, Vaccaro, I., additional, Rametta, R., additional, Ventura, V., additional, Bonvegna, A., additional, Alì, A., additional, Cinnirella, C., additional, Raineri, M., additional, Pompeo, F., additional, Cascio Ingurgio, N., additional, Carini, V., additional, Coco, R., additional, Giunta, G., additional, Leonardi, G., additional, Randazzo, V., additional, Di Blasi, V., additional, Tamburino, C., additional, Russo, G., additional, Mangiameli, S., additional, Cardillo, R., additional, Castelli, D., additional, Inserra, V., additional, Arena, A., additional, Gulizia, M.M., additional, Raciti, S., additional, Rapisarda, G., additional, Romano, R., additional, Prestifilippo, P., additional, Braschi, G.B., additional, Ledda, G., additional, Terrazzino, R., additional, De Caro, M., additional, Scilabra, G., additional, agnino, B., additional, Grassi, R., additional, Di Tano, G., additional, Scimone, G.F., additional, Vasquez, L., additional, Coppolino, C., additional, Casale, A., additional, Castelli, M., additional, D'Urso, G., additional, D'Antonio, E., additional, Lo Presti, L., additional, Badalamenti, E., additional, Conti, P., additional, Sanfilippo, N., additional, Cirrincione, V., additional, Cinà, M.T., additional, Cusimano, G., additional, Taormina, A., additional, Giuliano, P., additional, Bajardi, A., additional, Mandalà, V., additional, Canonico, A., additional, Geraci, G., additional, Sabella, F.P., additional, Enia, F., additional, Floresta, A.M., additional, Lo Cascio, I., additional, Gumina, D., additional, Cavallaro, A., additional, Piccione, G., additional, Ferrante, R., additional, Blandino, M., additional, Iudicello, M.S., additional, Mossuti, E., additional, Romano, G., additional, Lombardo, L., additional, Monastra, P., additional, Di Vincenzo, D., additional, Porcu, M., additional, Orrù, P., additional, Muscas, F., additional, Giardina, G., additional, Corda, M., additional, Locci, G., additional, Podda, A., additional, Ledda, M., additional, Siddi, P., additional, Lai, C., additional, Pili, G., additional, Mercuro, G., additional, Mureddu, G., additional, Ganau, A., additional, Meloni, G., additional, Poddighe, G., additional, and Sanna, G., additional

Published
2017
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43. Regular Wine Consumption in Chronic Heart Failure: Impact on Outcomes, Quality of Life, and Circulating Biomarkers

Author

Cosmi, Franco, Di Giulio, Paola, Masson, Serge, Finzi, Andrea, Marfisi, Rosa Maria, Cosmi, Deborah, Scarano, Marco, Tognoni, Gianni, Maggioni, Aldo P., Porcu, Maurizio, Boni, Silvana, Cutrupi, Giovanni, Tavazzi, Luigi, Latini, Roberto Tavazzi, L, Tognoni, G, Barlera, S, Franzosi, Mg, Latini, R, Lucci, D, Maggioni, Ap, Marchioli, R, Nicolosi, Gl, Porcu, M, Yusuf, S, Camerini, F, Cohn, Jn, Decarli, A, Pitt, B, Sleight, P, Poole-Wilson, Pa, Geraci, E, Scherillo, M, Fabbri, G, Bartolomei, B, Bertoli, D, Cobelli, F, Fresco, C, Ledda, A, Levantesi, G, Opasich, C, Rusconi, F, Sinagra, G, Turazza, F, Volpi, A, Ceseri, M, Alongi, G, Atzori, A, Bambi, F, Bastarolo, D, Bianchini, F, Cangioli, I, Canu, V, Caporusso, C, Cenni, G, Cintelli, L, Cocchio, M, Confente, A, Fenicia, E, Friso, G, Gianfriddo, M, Grilli, G, Lazzaro, B, Lonardo, G, Luise, A, Nota, R, Orlando, M, Petrolo, R, Pierattini, C, Pierota, V, Provenzani, A, Quartuccio, V, Ragno, A, Serio, C, Spolaor, A, Tafi, A, Tellaroli, E, Ghio, S, Ghizzardi, E, Masson, S, Crociati, L, Rovere, Mt, Corra, U, Di Giulio, P, Finzi, A, Gorini, M, Gonzini, L, Milani, V, Orsini, G, Bianchini, E, Cabiddu, S, Cipressa, L, Cipressa, Ml, Di Bitetto, G, Ferri, B, Galbiati, L, Lorimer, A, Pera, C, Priami, P, Rossi, Mg, Pasotti, E, Vaghi, F, Roncarolo, P, Zunino, Mt, Matta, F, Actis, E, Gaita, F, Azzaro, G, Zanetta, M, Paino, Am, Parravicini, U, Vegis, D, Conte, R, Ferraro, P, De Bernardi, A, Morelloni, S, Fagnani, M, Lucchina, Pg, Montagna, L, Bellone, E, Sappe, D, Ferraro, F, Delucchi, M, Reynaud, Sg, Dore, M, La, A, Massobrio, N, Bo, L, Trinchero, R, Imazio, M, Brocchi, G, Nejrotti, A, Rissone, L, Gabasio, S, Zocchi, C, Randazzo, S, Crenna, A, Giannuzzi, P, Bonanomi, E, Mezzani, A, De Marchi, M, Begliuomini, G, Gianonatti, Ca, Gavazzi, A, Grosu, A, Cas, Ld, Nodari, S, Garyfallidis, P, Bertoletti, A, Bonifazi, C, Arisi, S, Mascaro, F, Fraccarollo, M, Dell, S, Sfolcini, M, Bortolini, F, Raccagni, D, Turelli, A, Santarone, M, Miglierina, E, Sormani, L, Jemoli, R, Tettamanti, F, Pirelli, S, Bianchi, C, Verde, S, Mariani, M, Ziacchi, V, Ferrazza, A, Russo, A, Bortolotti, M, Pasini, Gf, Jones, Kn, Cuzzucrea, D, Gullace, G, Carbone, C, Granata, A, De, S, Del Rosso, G, Inserra, C, Renaldini, E, Zappa, C, Moretti, M, Zanini, R, Ferrari, M, Cei, A, Lissi, C, Dovico, E, Fiorentini, C, Palermo, P, Brusoni, B, Negrini, M, Heyman, J, Danzi, Gb, Frigerio, M, Beretta, L, Sachero, A, Casazza, F, Squadroni, L, Lombardi, F, Marano, L, Margonato, A, Fragasso, G, Febo, Oc, Aiolfi, E, Olmetti, F, Grieco, A, Antonazzo, V, Specchia, G, Mortara, A, Robustelli, F, Songini, Mg, Schweiger, C, Frisinghelli, A, Palvarini, M, Campana, C, Scelsi, L, Marsan, Na, Gualco, A, De Feo, S, Iannone, Ma, Diaco, T, Zaniboni, D, Milanesi, G, Nassiacos, D, Meloni, S, Giani, P, Nicoli, T, Malinverni, C, Gusmini, A, Pozzoni, L, Bisiani, G, Margaroli, P, Schizzarotto, A, Daverio, A, Morelli, E, Occhi, G, Partesana, N, Bandini, P, Rosella, Mg, Giustiniani, S, Cucchi, G, Pedretti, R, Raimondo, R, Vaninetti, R, Fedele, A, Ghezzi, I, Rezzonico, E, Salerno, Ja, Morandi, F, Salvucci, F, Valenti, C, Graziano, G, Romano, M, Cimminiello, C, Mangone, I, Lombardo, M, Quorso, P, Marinoni, G, Breghi, M, Erckert, M, Dienstl, A, Mirante, G, Stefenelli, C, Cioffi, G, Buczkowska, E, Bonanome, A, Bazzanini, F, Parissenti, L, Serafini, C, Catania, G, Tarantini, L, Rigatelli, G, Boni, S, Pasini, A, Masini, E, Zampiero, Aa, Zanchetta, M, Franceschetto, L, Delise, P, Marcon, C, Sacchetta, A, Borgese, L, Artusi, L, Casolino, P, Corbara, F, Banzato, A, Barbiero, M, Aldegheri, Mp, Bazzucco, R, Crivellenti, G, Raviele, A, Zanella, C, Pascotto, P, Sarto, P, Milan, S, Barbieri, E, Girardi, P, Dalla, W, Mule, Jd, Di Sipio ML, Cazzin, R, Milan, D, Zonzin, P, Carraro, M, Rossi, R, Carbonieri, E, Rossi, I, Stritoni, P, Meneghetti, P, Risica, G, Tenderini, Pl, Vassanelli, C, Zanolla, L, Perini, G, Brighetti, G, Chiozza, R, Giuliano, G, Baldin, Mg, Gortan, R, Cesanelli, R, Piazza, R, Mos, L, Vriz, O, Pavan, D, Pascottini, G, Alberti, E, Werren, M, Solinas, L, Longaro, F, Fioretti, P, Albanese, Mc, Miani, D, Gianrossi, R, Pende, A, Rubartelli, P, Magaia, O, Caruso, D, Faraguti, As, Magliani, L, Miccoli, F, Guglielmino, G, Cantarelli, A, Orlandi, S, Vallebona, A, Pozzati, A, Brega, G, Pancaldi, Lg, Vandelli, R, Urbinati, S, Poci, Mg, Zoli, M, Costa, Gm, Guiducci, U, Zobbi, G, Tartagni, F, Tisselli, A, Gentili, A, Pieri, P, Cagnetta, E, Bendinelli, S, Barbieri, A, Conti, R, Ferrari, R, Merlini, F, Fucili, A, Moruzzi, P, Buia, E, Galvani, M, Ferrini, D, Baggioni, G, Yiannacopulu, P, Canè, G, Bonfiglioli, A, Zandomeneghi, R, Brugioni, L, Giannini, A, Di, R, Giuliani, M, Rusconi, L, Del Corso, P, Piovaccari, G, Bologna, F, Venturi, P, Melandri, F, Bagni, E, Bolognese, L, Perticucci, R, Zuppiroli, A, Nannini, M, Consoli, N, Petrone, P, Pipitò, C, Colombi, L, Bernardi, D, Mariani, Pr, Testa, R, Mazzinghi, F, Cosmi, F, Cosmi, D, Zipoli, A, Cecchi, A, Castelli, G, Ciaccheri, M, Mori, F, Pieri, F, Valoti, P, Chiarantini, D, Santoro, Gm, Minneci, C, Marchi, F, Milli, M, Zambaldi, G, Geri, Aa, Cipriani, M, Alessandri, M, Severi, S, Stefanelli, S, Comella, A, Poddighe, R, Digiorgio, A, Carluccio, M, Berti, S, Rizza, A, Bonatti, V, Molendi, V, Brancato, A, D'Aprile, N, Giappichini, G, Del Vecchio, S, Mantini, G, De Tommasi, F, Meucci, G, Cordoni, M, Bechi, S, Barsotti, L, Baldini, P, Romei, M, Scopelliti, G, Lauri, G, Pestelli, F, Furiozzi, F, Cocchieri, M, Severini, D, Patriarchi, F, Chiocchi, P, Buccolieri, M, Martinelli, S, Wee, A, Angelici, F, Bernardinangeli, M, Proietti, G, Biscottini, B, Panciarola, R, Marinacci, L, Perna, Gp, Gabrielli, D, Moraca, A, Moretti, L, Partemi, L, Gregori, G, Amici, R, Patteri, G, Capone, P, Savini, E, Morgagni, Gl, Paccaloni, L, Pezzuoli, F, Carincola, S, Papi, S, De Crescentini, S, Gerardi, P, Midi, P, Gallenzi, E, Pajes, G, Mancone, C, Di, V, Di Gennaro, M, Calcagno, S, Toscano, S, Antonicoli, S, Carta, F, Giorgi, G, Comito, F, Daniele, E, Goretti, Sm, Ciarla, O, Gelfo, Pg, Acquaviva, A, Testa, D, Testa, G, Pagliaro, Fa, Russo, F, Vetta, F, Marchese, I, Di, G, D'Ambrosio, A, Leggio, F, Del Sindaco, D, Lacchè, A, Avallone, A, Risa, Mp, Azzolini, P, Baldo, E, Giovannini, E, Pulignano, G, Tondo, C, Picchio, E, Biffani, E, Tanzi, P, Pozzar, F, Farnetti, F, Azzarito, M, Santini, M, Varveri, A, Ferraiuolo, G, Valtorta, C, Gaspardone, A, Barbato, G, Ceci, V, Aspromonte, N, Bellocci, F, Colizzi, C, Fedele, F, Perez, Fi, Galati, A, Rossetti, A, Mainella, A, Ciuffetta, D, Matteucci, C, Busi, G, De, A, Farina, G, Granatelli, A, Leone, F, Frasca, F, Castellani, G, Massaro, G, Mastrogiuseppe, G, Vacri, A, De Sanctis, F, Cioli, M, Di Luzio, S, Napoletano, C, Piccioni, Ll, De Simone, G, Ottaviano, A, Mazza, V, Spedaliere, C, Staniscia, Td, Calgione, E, De Marco, G, Chiacchio, T, Di, T, Romanzi, S, Salvatore, G, Golino, P, Palermo, A, Mascia, F, Vetrano, A, Vinciguerra, A, Caliendo, L, Longobardi, R, De Caro, G, Di Nola, R, Piemonte, F, Prinzi, D, De Rosa, P, De, V, Riello, F, Capuano, V, Vecchio, G, Landi, M, Amato, S, Garofalo, M, D'Avino, M, Sensale, P, Maiolica, O, Santoro, R, Caso, P, Miceli, D, Maurea, N, Bianchi, U, Crispo, C, Chiariello, M, Filardi, Pp, Russo, L, Capuano, N, Ungaro, G, Vergara, G, Scafuro, F, D'Angelo, G, Campaniello, C, Bottiglieri, P, Volpe, A, Battista, R, De Risi, L, Cardillo, G, Sibilio, G, Marino, Ap, Silvestri, F, Predotti, P, Iervoglini, A, De Matteis, C, Sarnicola, P, Matarazzo, Mm, Baldi, S, Iuliano, V, Astarita, C, Cuccaro, P, Liguori, A, Liguori, G, Gregorio, G, Petraglia, L, Antonelli, G, Amodio, G, De Luca, I, Franchini, G, Lenti, Ml, Cavallari, D, D'Agostino, C, Scalera, G, Altamura, Cm, Russo, M, Mascolo, Ar, Pettinati, G, Ciricugno, Sa, Scrutinio, D, Passantino, A, Mastrangelo, D, Di Masi, A, De, R, Cannone, M, Dibiase, F, Pensato, M, Loliva, F, Trapani, F, Panettieri, I, Leone, L, Di, M, Carrone, M, Gallone, V, Cocco, F, Costantini, M, Tritto, C, Cavalieri, F, Stella, L, Magliari, F, Callerame, M, De Giorgi, A, Pellegrino, L, Correra, M, Portulano, V, Nisi, Gl, Grassi, G, Cristallo, E, De Laura, D, Salerno, C, Fanelli, R, Villella, M, Pede, S, Renna, A, De Lorenzi, E, Urso, L, Lenti, V, Peluso, A, Baldi, N, Polimeni, G, Palma, P, Lauletta, R, Tagliamonte, E, Cirillo, T, Centonze, G, D'Alessandro, B, Truncellito, L, Mecca, D, Petruzzi, Ma, Coviello, Ro, Lopizzo, A, Chiaffitelli, M, Barbuzzi, S, Gubelli, S, Germinario, G, Cosentino, N, Mingrone, A, Vico, R, Borrello, G, Mazza, Ml, Cimino, R, Galasso, D, Cassadonte, F, Talarico, U, Perticone, F, Cassano, S, Catapano, F, Calemme, S, Feraco, E, Cloro, C, Misuraca, G, Caporale, R, Vigna, L, Spagnuolo, V, De Rosa, F, Spadafora, G, Zampaglione, G, Russo, R, Schipani, Fa, Ferragina, Af, Stranieri, D, Musca, G, Carpino, C, Bencardino, P, Raimondo, F, Musacchio, D, Pulitano, G, Ruggeri, A, Provenzano, A, Salituri, S, Musolino, M, Calandruccio, S, Marrari, A, Tripodi, E, Scali, R, Anastasio, L, Arone, A, Aragona, P, Donnangelo, L, Comito, Mg, Bilotta, F, Vaccaro, I, Rametta, R, Ventura, V, Bonvegna, A, Alì, A, Cinnirella, C, Raineri, M, Pompeo, F, Ingurgio, Nc, Carini, V, Coco, R, Giunta, G, Leonardi, G, Randazzo, V, Di Blasi, V, Tamburino, C, Russo, G, Mangiameli, S, Cardillo, R, Castelli, D, Inserra, V, Arena, A, Gulizia, Mm, Raciti, S, Rapisarda, G, Romano, R, Prestifilippo, P, Braschi, Gb, Ledda, G, Terrazzino, R, De Caro, M, Scilabra, G, Graffagnino, B, Grassi, R, Scimone, Gf, Vasquez, L, Coppolino, C, Casale, A, Castelli, M, D'Urso, G, D'Antonio, E, Presti, Ll, Badalamenti, E, Conti, P, Sanfilippo, N, Cirrincione, V, Cinà, Mt, Cusimano, G, Taormina, A, Giuliano, P, Bajardi, A, Mandala, V, Canonico, A, Geraci, G, Sabella, Fp, Enia, F, Floresta, Am, Cascio, Il, Gumina, D, Cavallaro, A, Piccione, G, Ferrante, R, Blandino, M, Iudicello, Ms, Mossuti, E, Romano, G, Lombardo, L, Monastra, P, Di Vincenzo, D, Orru, P, Muscas, F, Giardina, G, Corda, M, Locci, G, Podda, A, Ledda, M, Siddi, P, Lai, C, Pili, G, Mercuro, G, Mureddu, G, Ganau, A, Meloni, G, Poddighe, G, Sanna, G., Cosmi, Franco, Di Giulio, Paola, Masson, Serge, Finzi, Andrea, Marfisi, Rosa Maria, Cosmi, Deborah, Scarano, Marco, Tognoni, Gianni, Maggioni, Aldo P, Porcu, Maurizio, Boni, Silvana, Cutrupi, Giovanni, Tavazzi, Luigi, Latini, Roberto, on behalf of the GISSI-HF, Investigator, Margonato, Alberto, DI GIULIO, Paola, Maggioni, Aldo P., GISSI HF, Investigator, and Sinagra, Gianfranco

Subjects
Male, Health Status, Left, Wine, Comorbidity, Ventricular Function, Left, Health Statu, Quality of life, Risk Factors, Surveys and Questionnaires, Prevalence, Ventricular Function, Surveys and Questionnaire, Depression (differential diagnoses), Depression, Medicine (all), Middle Aged, Prognosis, biological marker, Italy, Female, Risk assessment, Cardiology and Cardiovascular Medicine, biological markers, Human, Cardiac function curve, Vasculitis, medicine.medical_specialty, Vasculiti, Alcohol Drinking, Prognosi, Lower risk, Risk Assessment, Internal medicine, medicine, Humans, Protective Factor, Aged, Heart Failure, business.industry, Risk Factor, Stroke Volume, Biomarker, quality of life, wine, aged, alcohol drinking, biomarkers, chronic disease, comorbidity, depression, female, heart failure, humans, italy, male, middle aged, prevalence, prognosis, protective factors, risk assessment, risk factors, stroke volume, surveys and questionnaires, vasculitis, ventricular function, left, health status, cardiology and cardiovascular medicine, Biomarkers, Chronic Disease, Protective Factors, Quality of Life, medicine.disease, Clinical trial, Heart failure, Physical therapy, business
Abstract

Background— Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results— A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P P =0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P P =0.01) after adjusting for possible confounders. Conclusions— We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT0033633.

Published
2015

44. Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial

Author

Verdecchia P, Staessen JA, Angeli F, DE SIMONE, GIOVANNI, Achilli A, Ganau A, Mureddu G, Pede S, Maggioni AP, Lucci D, Reboldi G, Cardio Sis investigators, GALLETTI, FERRUCCIO, BARBATO, ANTONIO, STRAZZULLO, PASQUALE, Verdecchia, P, Staessen, Ja, Angeli, F, DE SIMONE, Giovanni, Achilli, A, Ganau, A, Mureddu, G, Pede, S, Maggioni, Ap, Lucci, D, Reboldi, G, Cardio Sis, Investigator, Galletti, Ferruccio, Barbato, Antonio, and Strazzullo, Pasquale

Subjects
hypertension, blood pressure
Published
2009

45. Precipitating factors and decision-making processes of short-term worsening heart failure despite 'optimal' treatment (from the IN-CHF Registry)

Author

Opasich, C., Rapezzi, C., Lucci, D., Gorini, M., Pozzar, F., Zanelli, E., Tavazzi, L., Mezzani, Maggioni A. P. AND THE IN CHF Investigators: A., Bielli, M., Milanese, U., Ugliengo, G., Pozzi, R., Rabajoli, F., Bosimini, E., Valsecchi, M. G., Dadda, F., Faggiano, P., Castiglioni, G., Gibelli, G., Turelli, A. L., Belluschi, R., Bianchi, C., Emanuelli, C., Gramenzi, S., Foti, G., Agnelli, D., Volterrani, M., Moroni, E., Gara, E., Turiel, A., Recalcati, F., Valenti, D., Rusconi, F., Palvarini, M., Giusti, A., Inserra, C., Nassiacos, D., Meloni, S., Nicoli, T., Bandini, P., Moizi, M., Pedretti, R., Paolucci, M., Amati, L., Ravetta, M., Morandi, F., Provasoli, S., Planca, E., Quorso, P., Ferro, A., Pedrolli, C., Riggi, L., Tarantini, L., Candelpergher, G., Berton, G., Stefanini, M. G., Cacciavillani, L., Boffa, G. M., Mario, L., Renosto, G., Stritoni, P., Perini, G., Bonadiman, C., Varotto, L., Penzo, M., Giuliano, G., Marini, R., Barducci), E., Humar, F., Albanese, M. C., Fresco, C., Camerini, A., Griffo, R., Derchi, G., Vengo, P., Fazzini, L., Pizzorno, L., Bertoli, D., Morgagni, G., Bruno, G., Iori, E., Melandri, F., Cionini, F., Reggianini, L., Passerini, F., Del Corso, P., Rusconi, L., Marzaloni, M., Mezzetti, M., Gambarati, G. P., Mariani, P. R., Volterrani, C., Venturi, F., Zambaldi, G., Geri Brandinelli, A., Taddei, T., Dalle Luche, A., Arcuri, G., Giannini, R., Gasperini, U., Alunni, G., Bosi, E., Cocchieri, M., Severini, D., Maragoni, G., C. Ferroni, G. Saccomanno, Pasetti, L., Budini, A., Manfrin, M., Coderoni, B., Mori, A., Midi, P., D. Del Sindaco, F. Leggio, Terranova, A., Pulignano, G., Cacciatore, G., Menichelli, M., Ansalone, G., Magris, B., Scaffidi, G., Valtorta, C., Salustri, A., Amaddeo, F., Barbato, G., Aspromonte, N., Renzi, M., Mantini, L., Frattaroli, C., Mariani, A., Di Marco, G., Levantesi, G., Colonna, N., Montano, A., Di Maggio, O., Toscano, G., Capuano, V., Scherillo, M., Sensale, P., Rullo, V., Maurea, N., Miceli, D., Somelli, A., Napolitano, F., Provvisiero, P., Di Muro, M. R., Bottiglieri, P., Rufolo, F., Ciriello, N., Angelini, E., Andriulo, C., De Santis, F., Cocco, F., Zecca, A., Pennetta, A., Mariello, F., Magliari, F., De Giorgi, A., Santoro, V., Pede, S., Renna, A., De Donno, O., De Lorenzi, E., Polimeni, G., Russo, V. A., Mangia, R., Cariello, F. P., Affinita, M., Perticone, F., Cloro, C., Misuraca, G., Caporale, R., Chiappetta, P., Tripodi, E., Tassone, F., Salituri, S., Errigo, C., Meringolo, G., Donnangelo, L., Canonico, G., Coco, R., Franco, M., Coglitore, A., Donato, A., Di Tano, G., Cento, D., DE GREGORIO, Cesare, Mongiovì, M., Schillaci, A. M., Mirto, U., Clemenza, F., Ingrillì, F., Aloisi, B., Porcu, M., Pili, G., and Piras, S.

Subjects
Male, medicine.medical_specialty, Heart disease, Decision Making, Risk Factors, Internal medicine, Heart rate, Humans, Medicine, Decompensation, Prospective Studies, Registries, Practice Patterns, Physicians', Intensive care medicine, Prospective cohort study, Aged, Heart Failure, business.industry, Atrial fibrillation, Middle Aged, Prognosis, medicine.disease, Blood pressure, Heart failure, Multivariate Analysis, Emergency medicine, Ambulatory, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract

This study sought to prospectively assess which factors were related to short-term worsening heart failure (HF) leading to or not to hospital admission, in long-term outpatients followed by cardiologists. The subsequent decision-making process was also analyzed. The study population consisted of 2,701 outpatients enrolled in the registry of the Italian Network on Congestive Heart Failure (IN-CHF) and followed by 133 cardiology centers (19% of all existing Italian cardiology centers). Clinical and follow-up data were collected by local trained clinicians; 215 patients (8%) had short-term decompensation (on average 2 months after the index outpatient visit). Multivariate analysis showed that previous hospitalization, long duration of symptoms, ischemic etiology, atrial fibrillation, higher functional class (New York Heart Association classification III to IV), higher heart rate, and low systolic blood pressure were independently associated with HF destabilization. Poor compliance (21%) and infection (12%) were the most frequent precipitating factors, but a precipitating factor was not identified in 40% of the patients. Poor compliance was more common in women, but no other clinical characteristics emerged as being related with a specific precipitating factor. Fifty-seven percent of the patients with a short-term recurrence of worsening HF required hospital admission; infusion treatment with inotropes and/or vasodilators was necessary in 19% of them. Long-term therapy was changed in 48% of the patients. Thus, in ambulatory HF patients, short-term worsening HF can be predicted according to the clinical characteristics on an outpatient basis. Nearly 1/3 of precipitating factors can be prevented. Patient education and avoidance of inappropriate treatment may reduce the number of relapses.

Published
2001
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46. Randomized study of traditional versus aggressive systolic blood pressure control (Cardio-Sis): rationale, design and characteristics of the study population. Cardio-Sis Study Group

Author

Verdecchia P, Staessen JA, Achilli A, DE SIMONE, GIOVANNI, Ganau A, Mureddu G, Pede S, Porcellati C, Fornari G, Repaci S, Castellani C, Achilli P, Jaspers C, Cucchiara G, Panzano C, Angeli F, Aillon C, Sclavo MG, Scherillo M, Raucci D, Di Donato M, Cas LD, Faggiano P, Porcu M, Calamida R, Pistia L, Vancheri F, Alletto M, Curcio M, Pettinati G, Ieva M, Muscella A, Guerrieri M, Denbek C, Gulizia M, Francese GM, Perticone F, Iemma G, Fariello R, Sala N, Mezzetti A, Pierdomenico SD, Bucci M, Benemio G, Gattobigio R, Sacchi N, Cocchieri M, Prosciutti L, Battocchi P, Garognoli O, Arcelli G, Pirelli S, Emanuelli C, Braschi GB, Abrignani M, De Ferrari G, Ponremoli R, Igidbashian D, Marini R, Scarpino L, Mandorla S, Buccolieri M, Picchi L, Casolo G, Pardini M, Marracci G, STRAZZULLO, PASQUALE, GALLETTI, FERRUCCIO, BARBATO, ANTONIO, Cavallini C, Borgioni C, Seghieri G, Cipollini F, Arcangeli E, Boddi W, Palermo C, Savelli F, Lembo G, Vecchione C, Malatino L, Belluardo P, Zoccali C, Leonardis D, Mallamaci F, Lacchè A, Gentile C, Boccanelli A, Mureddu GF, Santini M, Colivicchi F, Ficili S, Uguccioni M, Nardozi C, Tedeschi A, Martin G, Zanata G, Mos L, Dialti V, Martina S, Renna A, Farina G, Tripodi E, Miserrafiti B, Scali R, Stornello M, Valvo E, Bernardinangeli M, Proietti G, Poddighe G, Biscottini B, Panciarola R, Boccali A, Veglio F, Rabbia F, Caserta M, Chiatto M, Stefenelli C, Cioffi G, Bonazza G, Scabbia EV, Bottoni D., Verdecchia, P, Staessen, Ja, Achilli, A, DE SIMONE, Giovanni, Ganau, A, Mureddu, G, Pede, S, Porcellati, C, Fornari, G, Repaci, S, Castellani, C, Achilli, P, Jaspers, C, Cucchiara, G, Panzano, C, Angeli, F, Aillon, C, Sclavo, Mg, Scherillo, M, Raucci, D, Di Donato, M, Cas, Ld, Faggiano, P, Porcu, M, Calamida, R, Pistia, L, Vancheri, F, Alletto, M, Curcio, M, Pettinati, G, Ieva, M, Muscella, A, Guerrieri, M, Denbek, C, Gulizia, M, Francese, Gm, Perticone, F, Iemma, G, Fariello, R, Sala, N, Mezzetti, A, Pierdomenico, Sd, Bucci, M, Benemio, G, Gattobigio, R, Sacchi, N, Cocchieri, M, Prosciutti, L, Battocchi, P, Garognoli, O, Arcelli, G, Pirelli, S, Emanuelli, C, Braschi, Gb, Abrignani, M, De Ferrari, G, Ponremoli, R, Igidbashian, D, Marini, R, Scarpino, L, Mandorla, S, Buccolieri, M, Picchi, L, Casolo, G, Pardini, M, Marracci, G, Strazzullo, Pasquale, Galletti, Ferruccio, Barbato, Antonio, Cavallini, C, Borgioni, C, Seghieri, G, Cipollini, F, Arcangeli, E, Boddi, W, Palermo, C, Savelli, F, Lembo, G, Vecchione, C, Malatino, L, Belluardo, P, Zoccali, C, Leonardis, D, Mallamaci, F, Lacchè, A, Gentile, C, Boccanelli, A, Mureddu, Gf, Santini, M, Colivicchi, F, Ficili, S, Uguccioni, M, Nardozi, C, Tedeschi, A, Martin, G, Zanata, G, Mos, L, Dialti, V, Martina, S, Renna, A, Farina, G, Tripodi, E, Miserrafiti, B, Scali, R, Stornello, M, Valvo, E, Bernardinangeli, M, Proietti, G, Poddighe, G, Biscottini, B, Panciarola, R, Boccali, A, Veglio, F, Rabbia, F, Caserta, M, Chiatto, M, Stefenelli, C, Cioffi, G, Bonazza, G, Scabbia, Ev, and Bottoni, D.

Abstract

The hypothesis that a therapeutic strategy aimed at lowering systolic blood pressure (SBP) below 130 mm Hg is superior to a conventional strategy targeted at below 140 mm Hg in hypertensive subjects has never been tested in randomized intervention studies. The Studio Italiano Sugli Effetti Cardiovascolari del Controllo della Pressione Arteriosa Sistolica (Cardio-Sis) is a multi-centre study in non-diabetic, treated hypertensive subjects aged >55 years with uncontrolled SBP (>or=150 mm Hg) and at least one additional cardiovascular risk factor (ClinicalTrials.gov identifier: NCT00421863). Subjects are randomized to an SBP goal

Published
2008

47. Prognostic value of serial electrocardiographic voltage and repolarization changes in essential hypertension: the HEART Survey study

Author

Verdecchia, P, Reboldi, Gianpaolo, Angeli, F, Avanzini, F, DE SIMONE, G, Pede, S, Perticone, F, Schillaci, Giuseppe, Vanuzzo, D, Maggioni, Ap, ON BEHALF OF THE HEART SURVEY STUDY GROUP, Verdecchia, P, Reboldi, G, Angeli, F, Avanzini, F, DE SIMONE, Giovanni, Pede, S, Perticone, F, Schillaci, G, Vanuzzo, D, Maggioni, Ap, and HEART SURVEY STUDY, Group

Subjects
Male, medicine.medical_specialty, Left ventricular hypertrophy, Essential hypertension, Sudden death, Electrocardiography, Internal medicine, Internal Medicine, medicine, Humans, Repolarization, Prospective Studies, cardiovascular diseases, Proportional hazards model, business.industry, Hazard ratio, Middle Aged, Prognosis, medicine.disease, Confidence interval, Heart failure, Hypertension, Multivariate Analysis, Cardiology, Female, Hypertrophy, Left Ventricular, business
Abstract

Background The interpretation of serial electrocardiographic (ECG) changes in hypertensive subjects is uncertain. We tested the hypothesis that serial changes in repolarization and voltage are independent determinants of outcome. Methods The Hypertrophy at ECG And its Regression during Treatment (HEART) Survey was a prospective observational study performed at 61 centers. We studied 711 subjects with hypertension and ECG left-ventricular hypertrophy (LVH) at entry. Tracings from 496 subjects at entry and one or more visits during follow-up were available for central reading. Results The prevalence of ECG LVH progressively decreased by 49.6% at 3 years. The crude rate of a prespecified primary composite end point of cardiovascular events was 4.17 per 100 subjects per year (95% confidence interval [CI], 3.27 to 5.33). We used Cox regression models of ECG LVH indexes as time-varying covariates at baseline and at follow-up. Time-varying LVH, defined as an absence of ST-T alterations (“strain”), was associated with a lower event rate hazard ratio (HR), 0.47; 95% CI, 0.28 to 0.78; P = .0035), whereas the LVH changes defined in terms of ECG voltages did not achieve significance (HR, 0.91; 95% CI, 0.74 to 1.13; P = .39). The crude event rate in subjects with versus without in-treatment ST-T alterations on the last available ECG before the event or before censoring was 8.38 versus 3.17 per 100 subjects per year ( P Conclusions In this study of subjects with hypertension and ECG LVH at entry, serial changes in repolarization significantly predicted the prognosis, independent of voltage change (which was not significantly predictive in this study). The persistence or new development of ST-T alterations identifies subjects at very high risk of cardiovascular events.

Published
2007

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