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A resilient city includes multiple energy carriers, high-efficiency infrastructure, lower resource demand to decarbonize and sustain the urban system in accordance with the Paris Agreement, the United Nations 2030 Agenda for Sustainable Development, and the various recovery plans following the COVID-19 pandemic period. To achieve these goals, a key role is played by all urban sectors, which can reduce environmental impacts and accelerate the green transition at larger scale. Intervening on a district scale obviously requires the evaluation of different aspects, taking into account both economic and non-economic criteria, as well as different points of view, involving all stakeholders. This paper proposes a multi-step evaluation procedure that extends the European manual-based Cost-Benefit Analysis (CBA) to include the extra-economic benefits and the stakeholders' opinion in the evaluation, according to the COmpoSIte Model for Assessment (COSIMA) method. This is the first application of COSIMA in the urban design sectors (i.e. buildings, water, public lighting, transportation and waste management) where different sustainable measures for a real case study located in Turin (Italy) were compared to define the most suitable transformation scenario according to multiple criteria. The results have shown how invasive scenarios allow achieving the greatest benefits, despite the huge initial costs of realization. • Decarbonizing the urban system is a priority nowadays. • Considering an urban regeneration process all urban sectors is necessary. • COSIMA proposes a standardized approach to evaluate projects at the district level. • The multi-step approach evaluates energy, environmental, social performances. • Sectors considered are residential buildings, water, transport, waste management. [ABSTRACT FROM AUTHOR]