545 results on '"Pedersen, Ole Birger"'
Search Results
2. Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage
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Westergaard, David, Steinthorsdottir, Valgerdur, Stefansdottir, Lilja, Rohde, Palle Duun, Wu, Xiaoping, Geller, Frank, Tyrmi, Jaakko, Havulinna, Aki S., Solé-Navais, Pol, Flatley, Christopher, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Erikstrup, Christian, Sørensen, Erik, Mikkelsen, Christina, Bruun, Mie Topholm, Aagaard Jensen, Bitten, Brodersen, Thorsten, Ullum, Henrik, Magnus, Per, Andreassen, Ole A., Njolstad, Pål R., Kolte, Astrid Marie, Krebs, Lone, Nyegaard, Mette, Hansen, Thomas Folkmann, Feenstra, Bjarke, Daly, Mark, Lindgren, Cecilia M., Thorleifsson, Gudmar, Stefansson, Olafur A., Sveinbjornsson, Gardar, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Banasik, Karina, Jacobsson, Bo, Laisk, Triin, Laivuori, Hannele, Stefansson, Kari, Brunak, Søren, and Nielsen, Henriette Svarre
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- 2024
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3. Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort
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Westergaard, David, Jørgensen, Frederik Hytting, Waaben, Jens, Jung, Alexander Wolfgang, Lademann, Mette, Hansen, Thomas Folkmann, Cremers, Jolien, Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Reguant, Roc, Jørgensen, Isabella Friis, Fitzgerald, Tom, Birney, Ewan, Banasik, Karina, Mortensen, Laust, and Brunak, Søren
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- 2024
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4. History of childhood maltreatment associated with hospitalization or death due to COVID-19: a cohort study
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Wang, Yue, Ge, Fenfen, Aspelund, Thor, Ask, Helga, Hauksdóttir, Arna, Hu, Kejia, Jakobsdóttir, Jóhanna, Zoega, Helga, Shen, Qing, Whalley, Heather C., Pedersen, Ole Birger Vesterager, Lehto, Kelli, Andreassen, Ole A., Fang, Fang, Song, Huan, and Valdimarsdóttir, Unnur A.
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- 2024
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5. Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors
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Olofsson, Isa Amalie, Kristjansson, Ragnar P., Callesen, Ida, Davidsson, Olafur, Winsvold, Bendik, Hjalgrim, Henrik, Ostrowski, Sisse R., Erikstrup, Christian, Bruun, Mie Topholm, Pedersen, Ole Birger, Burgdorf, Kristoffer S., Banasik, Karina, Sørensen, Erik, Mikkelsen, Christina, Didriksen, Maria, Dinh, Khoa Manh, Mikkelsen, Susan, Brunak, Søren, Ullum, Henrik, Chalmer, Mona Ameri, Olesen, Jes, Kogelman, Lisette J. A., and Hansen, Thomas Folkmann
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- 2024
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6. Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors
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Kjerulff, Bertram, Dowsett, Joseph, Jacobsen, Rikke Louise, Gladov, Josephine, Larsen, Margit Hørup, Lundgaard, Agnete Troen, Banasik, Karina, Westergaard, David, Mikkelsen, Susan, Dinh, Khoa Manh, Hindhede, Lotte, Kaspersen, Kathrine Agergård, Schwinn, Michael, Juul, Anders, Poulsen, Betina, Lindegaard, Birgitte, Pedersen, Carsten Bøcker, Sabel, Clive Eric, Bundgaard, Henning, Nielsen, Henriette Svarre, Møller, Janne Amstrup, Boldsen, Jens Kjærgaard, Burgdorf, Kristoffer Sølvsten, Kessing, Lars Vedel, Handgaard, Linda Jenny, Thørner, Lise Wegner, Didriksen, Maria, Nyegaard, Mette, Grarup, Niels, Ødum, Niels, Johansson, Pär I., Jennum, Poul, Frikke-Schmidt, Ruth, Berger, Sanne Schou, Brunak, Søren, Jacobsen, Søren, Hansen, Thomas Folkmann, Lundquist, Tine Kirkeskov, Hansen, Torben, Sørensen, Torben Lykke, Sigsgaard, Torben, Nielsen, Kaspar René, Bruun, Mie Topholm, Hjalgrim, Henrik, Ullum, Henrik, Rostgaard, Klaus, Sørensen, Erik, Pedersen, Ole Birger, Ostrowski, Sisse Rye, and Erikstrup, Christian
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- 2024
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7. A genome-wide association study of social trust in 33,882 Danish blood donors
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Sequeros, Celia Burgos, Hansen, Thomas Folkmann, Westergaard, David, Louloudis, Ioannis, Kalamajski, Sebastian, Röder, Timo, Rohde, Palle Duun, Schwinn, Michael, Clemmensen, Line Harder, Didriksen, Maria, Nyegaard, Mette, Hjalgrim, Henrik, Nielsen, Kaspar René, Bruun, Mie Topholm, Ostrowski, Sisse Rye, Erikstrup, Christian, Mikkelsen, Susan, Sørensen, Erik, Pedersen, Ole Birger Vestager, Brunak, Søren, Banasik, Karina, and Giordano, Giuseppe Nicola
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- 2024
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8. Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination
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Steinthorsdottir, Valgerdur, Halldorsson, Bjarni V., Jonsson, Hakon, Palsson, Gunnar, Oddsson, Asmundur, Westergaard, David, Arnadottir, Gudny A., Stefansdottir, Lilja, Banasik, Karina, Esplin, M. Sean, Hansen, Thomas Folkmann, Brunak, Søren, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Erikstrup, Christian, Thorleifsson, Gudmar, Nadauld, Lincoln D., Haraldsson, Asgeir, Steingrimsdottir, Thora, Tryggvadottir, Laufey, Jonsdottir, Ingileif, Gudbjartsson, Daniel F., Hoffmann, Eva R., Sulem, Patrick, Holm, Hilma, Nielsen, Henriette Svarre, and Stefansson, Kari
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- 2024
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9. Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study
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Chen, Hao Yu, Dina, Christian, Small, Aeron M, Shaffer, Christian M, Levinson, Rebecca T, Helgadóttir, Anna, Capoulade, Romain, Munter, Hans Markus, Martinsson, Andreas, Cairns, Benjamin J, Trudsø, Linea C, Hoekstra, Mary, Burr, Hannah A, Marsh, Thomas W, Damrauer, Scott M, Dufresne, Line, Le Scouarnec, Solena, Messika-Zeitoun, David, Ranatunga, Dilrini K, Whitmer, Rachel A, Bonnefond, Amélie, Sveinbjornsson, Garðar, Daníelsen, Ragnar, Arnar, David O, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Gudbjartsson, Daníel F, Hólm, Hilma, Ghouse, Jonas, Olesen, Morten Salling, Christensen, Alex H, Mikkelsen, Susan, Jacobsen, Rikke Louise, Dowsett, Joseph, Pedersen, Ole Birger Vesterager, Erikstrup, Christian, Ostrowski, Sisse R, Center, Regeneron Genetics, O’Donnell, Christopher J, Budoff, Matthew J, Gudnason, Vilmundur, Post, Wendy S, Rotter, Jerome I, Lathrop, Mark, Bundgaard, Henning, Johansson, Bengt, Ljungberg, Johan, Näslund, Ulf, Le Tourneau, Thierry, Smith, J Gustav, Wells, Quinn S, Söderberg, Stefan, Stefánsson, Kári, Schott, Jean-Jacques, Rader, Daniel J, Clarke, Robert, Engert, James C, and Thanassoulis, George
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Prevention ,Heart Disease ,Cardiovascular ,Genetics ,Human Genome ,Atherosclerosis ,2.1 Biological and endogenous factors ,Humans ,Genome-Wide Association Study ,Adiposity ,Genetic Predisposition to Disease ,Aortic Valve Stenosis ,Obesity ,Risk Factors ,Inflammation ,Dyslipidemias ,Apolipoproteins ,Mendelian Randomization Analysis ,Polymorphism ,Single Nucleotide ,Aortic stenosis ,Genome-wide association study ,Mendelian randomization ,Phenome-wide association study ,Gene expression ,Genetic risk score ,Regeneron Genetics Center ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
AimsAlthough highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS.Methods and resultsA genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European ancestry participants (13 765 cases) was performed. Seventeen loci were associated with AS at P ≤ 5 × 10-8, of which 15 replicated in an independent cohort of 90 828 participants (7111 cases), including CELSR2-SORT1, NLRP6, and SMC2. A genetic risk score comprised of the index variants was associated with AS [odds ratio (OR) per standard deviation, 1.31; 95% confidence interval (CI), 1.26-1.35; P = 2.7 × 10-51] and aortic valve calcium (OR per standard deviation, 1.22; 95% CI, 1.08-1.37; P = 1.4 × 10-3), after adjustment for known risk factors. A phenome-wide association study indicated multiple associations with coronary artery disease, apolipoprotein B, and triglycerides. Mendelian randomization supported a causal role for apolipoprotein B-containing lipoprotein particles in AS (OR per g/L of apolipoprotein B, 3.85; 95% CI, 2.90-5.12; P = 2.1 × 10-20) and replicated previous findings of causality for lipoprotein(a) (OR per natural logarithm, 1.20; 95% CI, 1.17-1.23; P = 4.8 × 10-73) and body mass index (OR per kg/m2, 1.07; 95% CI, 1.05-1.9; P = 1.9 × 10-12). Colocalization analyses using the GTEx database identified a role for differential expression of the genes LPA, SORT1, ACTR2, NOTCH4, IL6R, and FADS.ConclusionDyslipidemia, inflammation, calcification, and adiposity play important roles in the etiology of AS, implicating novel treatments and prevention strategies.
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- 2023
10. Developmental language disorder – heritability and genetic correlations with other disorders affecting language
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Banasik, Karina, Bay, Jakob, Kjærgaard Boldsen, Jens, Brodersen, Thorsten, Brunak, Søren, Demur, Alfonso Buil, Nordahl Christoffersen, Lea Arregui, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Mikkelsen, Dorte Helenius, Hindhede, Lotte, Hjalgrim, Henrik, von Stemann, Jakob Hjorth, Jensen, Bitten Aagaard, Schork, Andrew Joseph, Kaspersen, Kathrine, Kjerulff, Bertram Dalskov, Kongstad, Mette, Mikkelsen, Susan, Mikkelsen, Christina, Nissen, Janna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Elgaard Quinn, Liam James, Rafnar, Þórunn, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Sørensen, Erik, Stefansson, Kari, Stefánsson, Hreinn, Thørner, Lise Wegner, Þorsteinsdóttir, Unnur, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Nudel, Ron, Chrsitensen, Rikke Vang, Kalnak, Nelli, Lundberg, Mischa, Christoffersen, Lea Arregui Nordahl, Burgdorf, Kristoffer Sølvsten, Pedersen, Ole Birger Vesterager, Gísladóttir, Rósa S., and Walters, G. Bragi
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- 2024
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11. An atlas of genetic determinants of forearm fracture
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Nethander, Maria, Movérare-Skrtic, Sofia, Kämpe, Anders, Coward, Eivind, Reimann, Ene, Grahnemo, Louise, Borbély, Éva, Helyes, Zsuzsanna, Funck-Brentano, Thomas, Cohen-Solal, Martine, Tuukkanen, Juha, Koskela, Antti, Wu, Jianyao, Li, Lei, Lu, Tianyuan, Gabrielsen, Maiken E., Mägi, Reedik, Hoff, Mari, Lerner, Ulf H., Henning, Petra, Ullum, Henrik, Erikstrup, Christian, Brunak, Søren, Langhammer, Arnulf, Tuomi, Tiinamaija, Oddsson, Asmundur, Stefansson, Kari, Pettersson-Kymmer, Ulrika, Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Styrkarsdottir, Unnur, Mäkitie, Outi, Hveem, Kristian, Richards, J. Brent, and Ohlsson, Claes
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- 2023
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12. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
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Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn-Helen, Skotte, Line, Helgeland, Øyvind, Solé-Navais, Pol, Banasik, Karina, Albiñana, Clara, Ronkainen, Justiina, Fadista, João, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sánchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frédérique, Jacques, Pierre-Étienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A., Åsvold, Bjørn Olav, Atalay, Mustafa, Bhatta, Laxmi, Bouchard, Luigi, Brumpton, Ben Michael, Brunak, Søren, Bybjerg-Grauholm, Jonas, Ebbing, Cathrine, Elliott, Paul, Engelbrechtsen, Line, Erikstrup, Christian, Estarlich, Marisa, Franks, Stephen, Gaillard, Romy, Geller, Frank, Grove, Jakob, Hougaard, David M., Kajantie, Eero, Morgen, Camilla S., Nohr, Ellen A., Nyegaard, Mette, Palmer, Colin N. A., Pedersen, Ole Birger, Rivadeneira, Fernando, Sebert, Sylvain, Shields, Beverley M., Stoltenberg, Camilla, Surakka, Ida, Thørner, Lise Wegner, Ullum, Henrik, Vaarasmaki, Marja, Vilhjalmsson, Bjarni J., Willer, Cristen J., Lakka, Timo A., Gybel-Brask, Dorte, Bustamante, Mariona, Hansen, Torben, Pearson, Ewan R., Reynolds, Rebecca M., Ostrowski, Sisse R., Pennell, Craig E., Jaddoe, Vincent W. V., Felix, Janine F., Hattersley, Andrew T., Melbye, Mads, Lawlor, Deborah A., Hveem, Kristian, Werge, Thomas, Nielsen, Henriette Svarre, Magnus, Per, Evans, David M., Jacobsson, Bo, Järvelin, Marjo-Riitta, Zhang, Ge, Hivert, Marie-France, Johansson, Stefan, Freathy, Rachel M., Feenstra, Bjarke, and Njølstad, Pål R.
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- 2023
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13. Symptoms of attention deficit hyperactivity disorder are associated with Hidradenitis suppurativa in Danish blood donors
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Lindsø Andersen, Pernille, Villumsen, Bente, Saunte, Ditte Marie Lindhardt, Burgdorf, Kristoffer Sølvsten, Didriksen, Maria, Ostrowski, Sisse Rye, Thørner, Lise Wegner, Erikstrup, Christian, Dinh, Khoa Manh, Nielsen, Kaspar René, Brodersen, Thorsten, Bruun, Mie Topholm, Banasik, Karina, Hansen, Thomas Folkmann, Pedersen, Ole Birger, and Jemec, Gregor Borut
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- 2023
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14. suPARnostic: an advanced predictive tool for detecting recurrence in renal cell carcinoma
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Azawi, Nessn, Mosholt, Karina Sif Sondergaard, Fryd, Nathalie Demuth, Lund, Lars, Brignone, Juan Ignacio, Hvid, Nanna, Wulf-Johansson, Helle, Pedersen, Ole Birger Vesterager, Saekmose, Susanne Gjørup, and Dabestani, Saeed
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- 2023
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15. Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
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Oddsson, Asmundur, Sulem, Patrick, Sveinbjornsson, Gardar, Arnadottir, Gudny A., Steinthorsdottir, Valgerdur, Halldorsson, Gisli H., Atlason, Bjarni A., Oskarsson, Gudjon R., Helgason, Hannes, Nielsen, Henriette Svarre, Westergaard, David, Karjalainen, Juha M., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Jensson, Brynjar O., Tragante, Vinicius, Ferkingstad, Egil, Jonsson, Hakon, Gudjonsson, Sigurjon A., Beyter, Doruk, Moore, Kristjan H. S., Thordardottir, Helga B., Kristmundsdottir, Snaedis, Stefansson, Olafur A., Rantapää-Dahlqvist, Solbritt, Sonderby, Ida Elken, Didriksen, Maria, Stridh, Pernilla, Haavik, Jan, Tryggvadottir, Laufey, Frei, Oleksandr, Walters, G. Bragi, Kockum, Ingrid, Hjalgrim, Henrik, Olafsdottir, Thorunn A., Selbaek, Geir, Nyegaard, Mette, Erikstrup, Christian, Brodersen, Thorsten, Saevarsdottir, Saedis, Olsson, Tomas, Nielsen, Kaspar Rene, Haraldsson, Asgeir, Bruun, Mie Topholm, Hansen, Thomas Folkmann, Steingrimsdottir, Thora, Jacobsen, Rikke Louise, Lie, Rolv T., Djurovic, Srdjan, Alfredsson, Lars, Lopez de Lapuente Portilla, Aitzkoa, Brunak, Soren, Melsted, Pall, Halldorsson, Bjarni V., Saemundsdottir, Jona, Magnusson, Olafur Th., Padyukov, Leonid, Banasik, Karina, Rafnar, Thorunn, Askling, Johan, Klareskog, Lars, Pedersen, Ole Birger, Masson, Gisli, Havdahl, Alexandra, Nilsson, Bjorn, Andreassen, Ole A., Daly, Mark, Ostrowski, Sisse Rye, Jonsdottir, Ingileif, Stefansson, Hreinn, Holm, Hilma, Helgason, Agnar, Thorsteinsdottir, Unnur, Stefansson, Kari, and Gudbjartsson, Daniel F.
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- 2023
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16. Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
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Oddsson, Asmundur, Sulem, Patrick, Sveinbjornsson, Gardar, Arnadottir, Gudny A., Steinthorsdottir, Valgerdur, Halldorsson, Gisli H., Atlason, Bjarni A., Oskarsson, Gudjon R., Helgason, Hannes, Nielsen, Henriette Svarre, Westergaard, David, Karjalainen, Juha M., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Jensson, Brynjar O., Tragante, Vinicius, Ferkingstad, Egil, Jonsson, Hakon, Gudjonsson, Sigurjon A., Beyter, Doruk, Moore, Kristjan H. S., Thordardottir, Helga B., Kristmundsdottir, Snaedis, Stefansson, Olafur A., Rantapää-Dahlqvist, Solbritt, Sonderby, Ida Elken, Didriksen, Maria, Stridh, Pernilla, Haavik, Jan, Tryggvadottir, Laufey, Frei, Oleksandr, Walters, G. Bragi, Kockum, Ingrid, Hjalgrim, Henrik, Olafsdottir, Thorunn A., Selbaek, Geir, Nyegaard, Mette, Erikstrup, Christian, Brodersen, Thorsten, Saevarsdottir, Saedis, Olsson, Tomas, Nielsen, Kaspar Rene, Haraldsson, Asgeir, Bruun, Mie Topholm, Hansen, Thomas Folkmann, Steingrimsdottir, Thora, Jacobsen, Rikke Louise, Lie, Rolv T., Djurovic, Srdjan, Alfredsson, Lars, Lopez de Lapuente Portilla, Aitzkoa, Brunak, Soren, Melsted, Pall, Halldorsson, Bjarni V., Saemundsdottir, Jona, Magnusson, Olafur Th., Padyukov, Leonid, Banasik, Karina, Rafnar, Thorunn, Askling, Johan, Klareskog, Lars, Pedersen, Ole Birger, Masson, Gisli, Havdahl, Alexandra, Nilsson, Bjorn, Andreassen, Ole A., Daly, Mark, Ostrowski, Sisse Rye, Jonsdottir, Ingileif, Stefansson, Hreinn, Holm, Hilma, Helgason, Agnar, Thorsteinsdottir, Unnur, Stefansson, Kari, and Gudbjartsson, Daniel F.
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- 2023
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17. Developmental language disorder – a comprehensive study of more than 46,000 individuals
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Nudel, Ron, Christensen, Rikke Vang, Kalnak, Nelli, Schwinn, Michael, Banasik, Karina, Dinh, Khoa Manh, Erikstrup, Christian, Pedersen, Ole Birger, Burgdorf, Kristoffer Sølvsten, Ullum, Henrik, Ostrowski, Sisse Rye, Hansen, Thomas Folkmann, and Werge, Thomas
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- 2023
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18. Multiomics study of nonalcoholic fatty liver disease
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Sveinbjornsson, Gardar, Ulfarsson, Magnus O., Thorolfsdottir, Rosa B., Jonsson, Benedikt A., Einarsson, Eythor, Gunnlaugsson, Gylfi, Rognvaldsson, Solvi, Arnar, David O., Baldvinsson, Magnus, Bjarnason, Ragnar G., Eiriksdottir, Thjodbjorg, Erikstrup, Christian, Ferkingstad, Egil, Halldorsson, Gisli H., Helgason, Hannes, Helgadottir, Anna, Hindhede, Lotte, Hjorleifsson, Grimur, Jones, David, Knowlton, Kirk U., Lund, Sigrun H., Melsted, Pall, Norland, Kristjan, Olafsson, Isleifur, Olafsson, Sigurdur, Oskarsson, Gudjon R., Ostrowski, Sisse Rye, Pedersen, Ole Birger, Snaebjarnarson, Auðunn S., Sigurdsson, Emil, Steinthorsdottir, Valgerdur, Schwinn, Michael, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Jonsdottir, Ingileif, Bundgaard, Henning, Nadauld, Lincoln, Bjornsson, Einar S., Rulifson, Ingrid C., Rafnar, Thorunn, Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, Gudbjartsson, Daniel F., Holm, Hilma, and Stefansson, Kari
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- 2022
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19. The sequences of 150,119 genomes in the UK Biobank
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Halldorsson, Bjarni V., Eggertsson, Hannes P., Moore, Kristjan H. S., Hauswedell, Hannes, Eiriksson, Ogmundur, Ulfarsson, Magnus O., Palsson, Gunnar, Hardarson, Marteinn T., Oddsson, Asmundur, Jensson, Brynjar O., Kristmundsdottir, Snaedis, Sigurpalsdottir, Brynja D., Stefansson, Olafur A., Beyter, Doruk, Holley, Guillaume, Tragante, Vinicius, Gylfason, Arnaldur, Olason, Pall I., Zink, Florian, Asgeirsdottir, Margret, Sverrisson, Sverrir T., Sigurdsson, Brynjar, Gudjonsson, Sigurjon A., Sigurdsson, Gunnar T., Halldorsson, Gisli H., Sveinbjornsson, Gardar, Norland, Kristjan, Styrkarsdottir, Unnur, Magnusdottir, Droplaug N., Snorradottir, Steinunn, Kristinsson, Kari, Sobech, Emilia, Jonsson, Helgi, Geirsson, Arni J., Olafsson, Isleifur, Jonsson, Palmi, Pedersen, Ole Birger, Erikstrup, Christian, Brunak, Søren, Ostrowski, Sisse Rye, Thorleifsson, Gudmar, Jonsson, Frosti, Melsted, Pall, Jonsdottir, Ingileif, Rafnar, Thorunn, Holm, Hilma, Stefansson, Hreinn, Saemundsdottir, Jona, Gudbjartsson, Daniel F., Magnusson, Olafur T., Masson, Gisli, Thorsteinsdottir, Unnur, Helgason, Agnar, Jonsson, Hakon, Sulem, Patrick, and Stefansson, Kari
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- 2022
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20. A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome
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Skuladottir, Astros Th., Bjornsdottir, Gyda, Ferkingstad, Egil, Einarsson, Gudmundur, Stefansdottir, Lilja, Nawaz, Muhammad Sulaman, Oddsson, Asmundur, Olafsdottir, Thorunn A., Saevarsdottir, Saedis, Walters, G. Bragi, Magnusson, Sigurdur H., Bjornsdottir, Anna, Sveinsson, Olafur A., Vikingsson, Arnor, Hansen, Thomas Folkmann, Jacobsen, Rikke Louise, Erikstrup, Christian, Schwinn, Michael, Brunak, Søren, Banasik, Karina, Ostrowski, Sisse Rye, Troelsen, Anders, Henkel, Cecilie, Pedersen, Ole Birger, Jonsdottir, Ingileif, Gudbjartsson, Daniel F., Sulem, Patrick, Thorgeirsson, Thorgeir E., Stefansson, Hreinn, and Stefansson, Kari
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- 2022
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21. Low adherence to the guideline for the acute treatment of migraine
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Olesen, Astrid, Schytz, Henrik Winther, Ostrowski, Sisse Rye, Topholm, Mie, Nielsen, Kaspar, Erikstrup, Christian, Mikkelsen, Susan, Pedersen, Ole Birger, Olesen, Jes, Hansen, Thomas Folkmann, and Chalmer, Mona Ameri
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- 2022
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22. Chronic inflammation markers and cytokine-specific autoantibodies in Danish blood donors with restless legs syndrome
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Dowsett, Joseph, Didriksen, Maria, von Stemann, Jakob Hjorth, Larsen, Margit Hørup, Thørner, Lise Wegner, Sørensen, Erik, Erikstrup, Christian, Pedersen, Ole Birger, Hansen, Morten Bagge, Eugen-Olsen, Jesper, Banasik, Karina, and Ostrowski, Sisse Rye
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- 2022
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23. Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection
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Hønge, Bo Langhoff, Hindhede, Lotte, Kaspersen, Kathrine Agergård, Harritshøj, Lene Holm, Mikkelsen, Susan, Holm, Dorte Kinggaard, Nilsson, Anna Christine, Sækmose, Susanne Gjørup, Sørensen, Erik, Aagaard, Bitten, Hjalgrim, Henrik, Jørgensen, Charlotte Sværke, Krause, Tyra Grove, Ullum, Henrik, Pedersen, Ole Birger Vestager, Ostrowski, Sisse Rye, and Erikstrup, Christian
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- 2022
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24. Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
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Hautakangas, Heidi, Winsvold, Bendik S., Ruotsalainen, Sanni E., Bjornsdottir, Gyda, Harder, Aster V. E., Kogelman, Lisette J. A., Thomas, Laurent F., Noordam, Raymond, Benner, Christian, Gormley, Padhraig, Artto, Ville, Banasik, Karina, Bjornsdottir, Anna, Boomsma, Dorret I., Brumpton, Ben M., Burgdorf, Kristoffer Sølvsten, Buring, Julie E., Chalmer, Mona Ameri, de Boer, Irene, Dichgans, Martin, Erikstrup, Christian, Färkkilä, Markus, Garbrielsen, Maiken Elvestad, Ghanbari, Mohsen, Hagen, Knut, Häppölä, Paavo, Hottenga, Jouke-Jan, Hrafnsdottir, Maria G., Hveem, Kristian, Johnsen, Marianne Bakke, Kähönen, Mika, Kristoffersen, Espen S., Kurth, Tobias, Lehtimäki, Terho, Lighart, Lannie, Magnusson, Sigurdur H., Malik, Rainer, Pedersen, Ole Birger, Pelzer, Nadine, Penninx, Brenda W. J. H., Ran, Caroline, Ridker, Paul M., Rosendaal, Frits R., Sigurdardottir, Gudrun R., Skogholt, Anne Heidi, Sveinsson, Olafur A., Thorgeirsson, Thorgeir E., Ullum, Henrik, Vijfhuizen, Lisanne S., Widén, Elisabeth, van Dijk, Ko Willems, Aromaa, Arpo, Belin, Andrea Carmine, Freilinger, Tobias, Ikram, M. Arfan, Järvelin, Marjo-Riitta, Raitakari, Olli T., Terwindt, Gisela M., Kallela, Mikko, Wessman, Maija, Olesen, Jes, Chasman, Daniel I., Nyholt, Dale R., Stefánsson, Hreinn, Stefansson, Kari, van den Maagdenberg, Arn M. J. M., Hansen, Thomas Folkmann, Ripatti, Samuli, Zwart, John-Anker, Palotie, Aarno, and Pirinen, Matti
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- 2022
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25. No association between plasma hepcidin levels and restless legs syndrome - results from the Danish Blood Donor Study
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Dowsett, Joseph, Didriksen, Maria, Larsen, Margit Hørup, Burgdorf, Kristoffer Sølvsten, Thørner, Lise Wegner, Sørensen, Erik, Erikstrup, Christian, Pedersen, Ole Birger, Ostrowski, Sisse Rye, and Ullum, Henrik
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- 2021
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26. Trends in Lower Extremity Artery Disease Repair Incidence, Comorbidity, and Mortality: A Danish Nationwide Cohort Study, 1996–2018
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Møller, Anders, primary, Eldrup, Nikolaj, additional, Wetterslev, Jørn, additional, Hellemann, Dorthe, additional, Nielsen, Henning, additional, Rostgaard, Klaus, additional, Hjalgrim, Henrik, additional, and Pedersen, Ole Birger, additional
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- 2024
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27. Investigations of the migraine-provoking effect of levcromakalim in patients with migraine with aura
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Thomsen, Andreas Vinther, primary, Al-Karagholi, Mohammad Al-Mahdi, additional, Hougaard, Anders, additional, Ostrowski, Sisse Rye, additional, Pedersen, Ole Birger, additional, Hansen, Thomas Folkmann, additional, and Ashina, Messoud, additional
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- 2024
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28. Trends in Abdominal Aortic Aneurysm Repair Incidence, Comorbidity, Treatment, and Mortality: A Danish Nationwide Cohort Study, 1996–2018
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Møller, Anders, primary, Eldrup, Nikolaj, additional, Wetterslev, Jørn, additional, Hellemann, Dorthe, additional, Nielsen, Henning, additional, Rostgaard, Klaus, additional, Hjalgrim, Henrik, additional, and Pedersen, Ole Birger, additional
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- 2024
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29. Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors
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Mikkelsen, Susan, Boldsen, Jens Kjærgaard, Møller, Bjarne Kuno, Dinh, Khoa Manh, Rostgaard, Klaus, Petersen, Mikkel Steen, Kaspersen, Kathrine Agergård, Pedersen, Ole Birger, Thørner, Lise Wegner, Handgaard, Linda Jenny, Ostrowski, Sisse Rye, Sigsgaard, Torben, and Erikstrup, Christian
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- 2021
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30. Sex and Population-Specific 99th Percentiles of Troponin for Myocardial Infarction in the Danish Population (DANSPOT)
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Hasselbalch, Rasmus Bo, Jørgensen, Nicoline, Kristensen, Jonas, Strandkjær, Nina, Kock, Thilde Olivia, Lange, Theis, Ostrowski, Sisse Rye, Nissen, Janna, Larsen, Margit Hørup, Pedersen, Ole Birger Vesterager, Bor, Mustafa Vakur, Afzal, Shoaib, Kamstrup, Pia Rørbæk, Dahl, Morten, Hilsted, Linda, Torp-Pedersen, Christian, Bundgaard, Henning, and Iversen, Kasper Karmark
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- 2024
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31. Homozygosity for a stop-gain variant in CCDC201causes primary ovarian insufficiency
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Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Oskarsson, Gudjon R., Styrkarsdottir, Unnur, Moore, Kristjan H. S., Isberg, Salvor, Halldorsson, Gisli H., Sveinbjornsson, Gardar, Westergaard, David, Nielsen, Henriette Svarre, Fridriksdottir, Run, Jensson, Brynjar O., Arnadottir, Gudny A., Jonsson, Hakon, Sturluson, Arni, Snaebjarnarson, Audunn S., Andreassen, Ole A., Walters, G. Bragi, Nyegaard, Mette, Erikstrup, Christian, Steingrimsdottir, Thora, Lie, Rolv T., Melsted, Pall, Jonsdottir, Ingileif, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Saemundsdottir, Jona, Magnusson, Olafur Th., Banasik, Karina, Sorensen, Erik, Masson, Gisli, Pedersen, Ole Birger, Tryggvadottir, Laufey, Haavik, Jan, Ostrowski, Sisse Rye, Stefansson, Hreinn, Holm, Hilma, Rafnar, Thorunn, Gudbjartsson, Daniel F., Sulem, Patrick, and Stefansson, Kari
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Age at menopause (AOM) has a substantial impact on fertility and disease risk. While many loci with variants that associate with AOM have been identified through genome-wide association studies (GWAS) under an additive model, other genetic models are rarely considered1. Here through GWAS meta-analysis under the recessive model of 174,329 postmenopausal women from Iceland, Denmark, the United Kingdom (UK; UK Biobank) and Norway, we study low-frequency variants with a large effect on AOM. We discovered that women homozygous for the stop-gain variant rs117316434(A) in CCDC201(p.(Arg162Ter), minor allele frequency ~1%) reached menopause 9 years earlier than other women (P= 1.3 × 10−15). The genotype is present in one in 10,000 northern European women and leads to primary ovarian insufficiency in close to half of them. Consequently, homozygotes have fewer children, and the age at last childbirth is 5 years earlier (P= 3.8 × 10−5). The CCDC201gene was only found in humans in 2022 and is highly expressed in oocytes. Homozygosity for CCDC201loss-of-function has a substantial impact on female reproductive health, and homozygotes would benefit from reproductive counseling and treatment for symptoms of early menopause.
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- 2024
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32. Trends in Abdominal Aortic Aneurysm Repair Incidence, Comorbidity, Treatment, and Mortality: A Danish Nationwide Cohort Study, 1996–2018
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Møller,Anders, Eldrup,Nikolaj, Wetterslev,Jørn, Hellemann,Dorthe, Nielsen,Henning, Rostgaard,Klaus, Hjalgrim,Henrik, Pedersen,Ole Birger, Møller,Anders, Eldrup,Nikolaj, Wetterslev,Jørn, Hellemann,Dorthe, Nielsen,Henning, Rostgaard,Klaus, Hjalgrim,Henrik, and Pedersen,Ole Birger
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Anders Møller,1,2 Nikolaj Eldrup,3â 5 Jørn Wetterslev,6 Dorthe Hellemann,1,5 Henning Bay Nielsen,7,8 Klaus Rostgaard,9,10 Henrik Hjalgrim,5,9â 11,* Ole Birger Pedersen5,10,12,* 1Department of Anesthesia and Intensive Care, Næstved-Slagelse-Ringsted, Slagelse Hospital, Slagelse, Denmark; 2Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 3Department of Vascular Surgery, Rigshospitalet, Copenhagen, Denmark; 4Danish Vascular Registry, Aarhus, Denmark; 5Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 6Private Office, Tuborg Sundpark, Hellerup, 2900, Denmark; 7Department of Anesthesia and Intensive care, Zealand University Hospital Roskilde, Roskilde, Denmark; 8Department of Nutrition, Exercise and Sport, Faculty of Science, University of Copenhagen, Copenhagen, Denmark; 9Danish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark; 10Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; 11Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark; 12Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark*These authors contributed equally to this workCorrespondence: Anders Møller, Department of Anesthesia and Intensive Care, Næstved-Slagelse-Ringsted Hospital, Fælledvej 11, Slagelse, DK-4200, Denmark, Tel +45 58 55 92 02, Email dr.andersm@gmail.comBackground: Significant changes in Western populationsâ abdominal aortic aneurysm (AAA) epidemiology have been reported following the introduction of screening, endovascular AAA repair, and reduced tobacco consumption. We report incidence and mortality of AAA repair in Denmark from 1996 to 2018, where AAA screening was not implemented.Methods: Nationwide cohort study of prospective data from population-based Danish registries covering 1996 to 2018. We identified 15,39
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- 2024
33. Biallelic variants in POPDC2 cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy
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Genetica Groep Van Tintelen, Cancer, Child Health, Circulatory Health, Nicastro, Michele, Vermeer, Alexa M C, Postema, Pieter G, Tadros, Rafik, Bowling, Forrest Z, Aegisdottir, Hildur M, Tragante, Vinicius, Mach, Lukas, Postma, Alex V, Lodder, Elisabeth M, van Duijvenboden, Karel, Zwart, Rob, Beekman, Leander, Wu, Lingshuang, van der Zwaag, Paul A, Alders, Mariëlle, Allouba, Mona, Aguib, Yasmine, Santomel, J Luis, de Una, David, Monserrat, Lorenzo, Miranda, Antonio M A, Kanemaru, Kazumasa, Cranley, James, van Zeggeren, Ingeborg E, Aronica, Eleonora M A, Ripolone, Michela, Zanotti, Simona, Sveinbjornsson, Gardar, Ivarsdottir, Erna V, Hólm, Hilma, Guðbjartsson, Daníel F, Skúladóttir, Ástrós Th, Stefánsson, Kári, Nadauld, Lincoln, Knowlton, Kirk U, Ostrowski, Sisse Rye, Sørensen, Erik, Vesterager Pedersen, Ole Birger, Ghouse, Jonas, Rand, Søren, Bundgaard, Henning, Ullum, Henrik, Erikstrup, Christian, Aagaard, Bitten, Bruun, Mie Topholm, Christiansen, Mette, Jensen, Henrik K, Carere, Deanna Alexis, Cummings, Christopher T, Fishler, Kristen, Tøring, Pernille Mathiesen, Brusgaard, Klaus, Juul, Trine Maxel, Saaby, Lotte, Winkel, Bo Gregers, Mogensen, Jens, Fortunato, Francesco, Comi, Giacomo Pietro, Ronchi, Dario, van Tintelen, J Peter, Noseda, Michela, Airola, Michael V, Christiaans, Imke, Wilde, Arthur A M, Wilders, Ronald, Clur, Sally-Ann, Verkerk, Arie O, Bezzina, Connie R, Lahrouchi, Najim, Genetica Groep Van Tintelen, Cancer, Child Health, Circulatory Health, Nicastro, Michele, Vermeer, Alexa M C, Postema, Pieter G, Tadros, Rafik, Bowling, Forrest Z, Aegisdottir, Hildur M, Tragante, Vinicius, Mach, Lukas, Postma, Alex V, Lodder, Elisabeth M, van Duijvenboden, Karel, Zwart, Rob, Beekman, Leander, Wu, Lingshuang, van der Zwaag, Paul A, Alders, Mariëlle, Allouba, Mona, Aguib, Yasmine, Santomel, J Luis, de Una, David, Monserrat, Lorenzo, Miranda, Antonio M A, Kanemaru, Kazumasa, Cranley, James, van Zeggeren, Ingeborg E, Aronica, Eleonora M A, Ripolone, Michela, Zanotti, Simona, Sveinbjornsson, Gardar, Ivarsdottir, Erna V, Hólm, Hilma, Guðbjartsson, Daníel F, Skúladóttir, Ástrós Th, Stefánsson, Kári, Nadauld, Lincoln, Knowlton, Kirk U, Ostrowski, Sisse Rye, Sørensen, Erik, Vesterager Pedersen, Ole Birger, Ghouse, Jonas, Rand, Søren, Bundgaard, Henning, Ullum, Henrik, Erikstrup, Christian, Aagaard, Bitten, Bruun, Mie Topholm, Christiansen, Mette, Jensen, Henrik K, Carere, Deanna Alexis, Cummings, Christopher T, Fishler, Kristen, Tøring, Pernille Mathiesen, Brusgaard, Klaus, Juul, Trine Maxel, Saaby, Lotte, Winkel, Bo Gregers, Mogensen, Jens, Fortunato, Francesco, Comi, Giacomo Pietro, Ronchi, Dario, van Tintelen, J Peter, Noseda, Michela, Airola, Michael V, Christiaans, Imke, Wilde, Arthur A M, Wilders, Ronald, Clur, Sally-Ann, Verkerk, Arie O, Bezzina, Connie R, and Lahrouchi, Najim
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- 2024
34. Trends in Abdominal Aortic Aneurysm Repair Incidence, Comorbidity, Treatment, and Mortality:A Danish Nationwide Cohort Study, 1996–2018
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Møller, Anders, Eldrup, Nikolaj, Wetterslev, Jørn, Hellemann, Dorthe, Nielsen, Henning Bay, Rostgaard, Klaus, Hjalgrim, Henrik, Pedersen, Ole Birger, Møller, Anders, Eldrup, Nikolaj, Wetterslev, Jørn, Hellemann, Dorthe, Nielsen, Henning Bay, Rostgaard, Klaus, Hjalgrim, Henrik, and Pedersen, Ole Birger
- Abstract
Background: Significant changes in Western populations’ abdominal aortic aneurysm (AAA) epidemiology have been reported following the introduction of screening, endovascular AAA repair, and reduced tobacco consumption. We report incidence and mortality of AAA repair in Denmark from 1996 to 2018, where AAA screening was not implemented. Methods: Nationwide cohort study of prospective data from population-based Danish registries covering 1996 to 2018. We identified 15,395 patients undergoing first-time AAA repair using the Danish Vascular Registry. Comorbidity was assessed by Charlson’s Comorbidity Index (CCI). Incidence rate (IR) ratios and mortality rate ratios (MRR) were estimated by multivariable Poisson and Cox regression, respectively. Results: Overall AAA repair IR decreased by 24% from 1996 through 2018, mainly reflecting a 53% IR reduction in ruptured AAA repairs in men. Overall, the IR decreased 52– 63% in age groups below 70 years and increased 81% among octogenarians. The proportion of intact AAAs repaired endovascularly increased from 2% in 1996– 1999 to 42% in 2015– 2018. For both ruptured and intact AAAs the CCI score increased by 0.9% annually independently of age and sex. The adjusted five-year MRR in 2016– 2018 vs.1996– 2000 was 0.46 (95% confidence interval (CI): 0.39– 0.54) following ruptured and 0.51 (95% CI: 0.44– 0.59) following intact AAA repair. Conclusion: In Denmark, overall AAA repair incidence decreased between 1996 and 2018, primarily reflecting a reduction among males and a shift to an older population requiring intervention. These trends mirror changes in tobacco consumption in Denmark. Regardless of age and comorbidity, AAA repair mortality decreased markedly during the study period., Background: Significant changes in Western populations’ abdominal aortic aneurysm (AAA) epidemiology have been reported following the introduction of screening, endovascular AAA repair, and reduced tobacco consumption. We report incidence and mortality of AAA repair in Denmark from 1996 to 2018, where AAA screening was not implemented. Methods: Nationwide cohort study of prospective data from population-based Danish registries covering 1996 to 2018. We identified 15,395 patients undergoing first-time AAA repair using the Danish Vascular Registry. Comorbidity was assessed by Charlson’s Comorbidity Index (CCI). Incidence rate (IR) ratios and mortality rate ratios (MRR) were estimated by multivariable Poisson and Cox regression, respectively. Results: Overall AAA repair IR decreased by 24% from 1996 through 2018, mainly reflecting a 53% IR reduction in ruptured AAA repairs in men. Overall, the IR decreased 52–63% in age groups below 70 years and increased 81% among octogenarians. The proportion of intact AAAs repaired endovascularly increased from 2% in 1996–1999 to 42% in 2015–2018. For both ruptured and intact AAAs the CCI score increased by 0.9% annually independently of age and sex. The adjusted five-year MRR in 2016–2018 vs.1996–2000 was 0.46 (95% confidence interval (CI): 0.39–0.54) following ruptured and 0.51 (95% CI: 0.44–0.59) following intact AAA repair. Conclusion: In Denmark, overall AAA repair incidence decreased between 1996 and 2018, primarily reflecting a reduction among males and a shift to an older population requiring intervention. These trends mirror changes in tobacco consumption in Denmark. Regardless of age and comorbidity, AAA repair mortality decreased markedly during the study period.
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- 2024
35. Trends in Lower Extremity Artery Disease Repair Incidence, Comorbidity, and Mortality:A Danish Nationwide Cohort Study, 1996–2018
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Møller, Anders, Eldrup, Nikolaj, Wetterslev, Jørn, Hellemann, Dorthe, Nielsen, Henning Bay, Rostgaard, Klaus, Hjalgrim, Henrik, Pedersen, Ole Birger, Møller, Anders, Eldrup, Nikolaj, Wetterslev, Jørn, Hellemann, Dorthe, Nielsen, Henning Bay, Rostgaard, Klaus, Hjalgrim, Henrik, and Pedersen, Ole Birger
- Abstract
Background: The prevalence of occlusive lower extremity artery disease (LEAD) is rising worldwide while European epidemiology data are scarce. We report incidence and mortality of LEAD repair in Denmark from 1996 through 2018, stratified on open aorto-iliac, open peripheral, and endovascular repair. Methods: A nationwide cohort study of prospective data from population-based Danish registers covering 1996 to 2018. Comorbidity was assessed by Charlson’s Comorbidity Index (CCI). Incidence rate (IR) ratios and mortality rate ratios (MRR) were estimated by multivariable Poisson and Cox regression, respectively. Results: We identified 41,438 unique patients undergoing 46,236 incident first-time LEAD repairs by either aorto-iliac- (n=5213), peripheral surgery (n=18,665) or percutaneous transluminal angioplasty (PTA, n=22,358). From 1996 to 2018, the age- and sex-standardized IR for primary revascularization declined from 71.8 to 50.2 per 100,000 person-years (IRR, 0.70; 95% CI, 0.66– 0.75). Following a 2.5-fold IR increase of PTA from 1996 to 2010, all three repair techniques showed a declining trend after 2010. The declining IR was driven by decreasing LEAD repair due to claudication, and by persons aged below 80 years, while the IR increased in persons aged above 80 years (p interaction< 0.001). LEAD repair was more frequent in men (IRRfemale vs male, 0.78; 95% CI, 0.77– 0.80), which was consistent over calendar time (p interaction=0.41). Crude mortality decreased following open/surgical repair, and increased following PTA, but all three techniques trended towards lower adjusted mortality comparing the start and the end of the study period (MRRaorto-iliac, 0.71; 95% CI, 0.54– 0.93 vs MRRperipheral, 0.76; 95% CI, 0.69– 0.83 vs MRRPTA, 0.96; 95% CI, 0.86– 1.07). Increasing age and CCI, male sex, smoking, and care dependency associated with increased mortality. Conclusion: The incidence rate of LEAD repair decreased in Denmark from 1996 to 2018, especially i, Background: The prevalence of occlusive lower extremity artery disease (LEAD) is rising worldwide while European epidemiology data are scarce. We report incidence and mortality of LEAD repair in Denmark from 1996 through 2018, stratified on open aorto-iliac, open peripheral, and endovascular repair. Methods: A nationwide cohort study of prospective data from population-based Danish registers covering 1996 to 2018. Comorbidity was assessed by Charlson’s Comorbidity Index (CCI). Incidence rate (IR) ratios and mortality rate ratios (MRR) were estimated by multivariable Poisson and Cox regression, respectively. Results: We identified 41,438 unique patients undergoing 46,236 incident first-time LEAD repairs by either aorto-iliac-(n=5213), peripheral surgery (n=18,665) or percutaneous transluminal angioplasty (PTA, n=22,358). From 1996 to 2018, the age-and sex-standardized IR for primary revascularization declined from 71.8 to 50.2 per 100,000 person-years (IRR, 0.70; 95% CI, 0.66–0.75). Following a 2.5-fold IR increase of PTA from 1996 to 2010, all three repair techniques showed a declining trend after 2010. The declining IR was driven by decreasing LEAD repair due to claudication, and by persons aged below 80 years, while the IR increased in persons aged above 80 years (p interaction<0.001). LEAD repair was more frequent in men (IRRfemale vs male, 0.78; 95% CI, 0.77– 0.80), which was consistent over calendar time (p interaction=0.41). Crude mortality decreased following open/surgical repair, and increased following PTA, but all three techniques trended towards lower adjusted mortality comparing the start and the end of the study period (MRRaorto-iliac, 0.71; 95% CI, 0.54–0.93 vs MRRperipheral, 0.76; 95% CI, 0.69–0.83 vs MRRPTA, 0.96; 95% CI, 0.86–1.07). Increasing age and CCI, male sex, smoking, and care dependency associated with increased mortality. Conclusion: The incidence rate of LEAD repair decreased in Denmark fro
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- 2024
36. Investigations of the migraine-provoking effect of levcromakalim in patients with migraine with aura
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Thomsen, Andreas Vinther, Al-Karagholi, Mohammad Al Mahdi, Hougaard, Anders, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Hansen, Thomas Folkmann, Ashina, Messoud, Thomsen, Andreas Vinther, Al-Karagholi, Mohammad Al Mahdi, Hougaard, Anders, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Hansen, Thomas Folkmann, and Ashina, Messoud
- Abstract
Background/Hypothesis Experimental provocation studies have yielded important insights in migraine pathophysiology. Levcromakalim has been previously shown to induce migraine-like attacks with and without aura. In this study, we aim to further explore the migraine aura-inducing potential of levcromakalim. Methods In a double-blind, randomized, placebo-controlled cross-over study, 27 adult participants with migraine with aura received intravenous infusions of levcromakalim and saline. Headache, aura and associated symptoms were evaluated for 24 hours following administration of the study drug. The primary endpoint was occurrence of migraine-like attacks with or without aura in the 24-hour observation period. Results Thirteen participants developed migraine-like attacks on the active day only (P = 0.0098), and four participants developed aura on the active day only (P = 0.68). The median time to onset of migraine-like headache was three hours, and the median time to onset of aura was 27.5 minutes. Conclusion/Interpretation Our findings affirm the potent migraine-inducing effect of levcromakalim. We observed a lower induction-rate of migraine aura than previously reported. Further studies are warranted to identify predictors of migraine aura following levcromakalim., BACKGROUND/HYPOTHESIS: Experimental provocation studies have yielded important insights in migraine pathophysiology. Levcromakalim has been previously shown to induce migraine-like attacks with and without aura. In this study, we aim to further explore the migraine aura-inducing potential of levcromakalim. METHODS: In a double-blind, randomized, placebo-controlled cross-over study, 27 adult participants with migraine with aura received intravenous infusions of levcromakalim and saline. Headache, aura and associated symptoms were evaluated for 24 hours following administration of the study drug. The primary endpoint was occurrence of migraine-like attacks with or without aura in the 24-hour observation period. RESULTS: Thirteen participants developed migraine-like attacks on the active day only (P = 0.0098), and four participants developed aura on the active day only (P = 0.68). The median time to onset of migraine-like headache was three hours, and the median time to onset of aura was 27.5 minutes. CONCLUSION/INTERPRETATION: Our findings affirm the potent migraine-inducing effect of levcromakalim. We observed a lower induction-rate of migraine aura than previously reported. Further studies are warranted to identify predictors of migraine aura following levcromakalim. CLINICALTRIALS.GOV IDENTIFIER: NCT04905654.
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- 2024
37. Blood donation and migraine relief:A national population cohort study in Denmark
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Davidsson, Olafur B., Rostgaard, Klaus, Chalmer, Mona A., Kogelman, Lisette J.A., Aagaard, Bitten, Brodersen, Thorsten, Bruun, Mie Topholm, Mikkelsen, Christina, Mikkelsen, Susan, Nyegaard, Mette, Pedersen, Ole Birger, Ullum, Henrik, Sørensen, Erik, Ostrowski, Sisse Rye, Erikstrup, Christian, Hansen, Thomas Folkmann, Hjalgrim, Henrik, Davidsson, Olafur B., Rostgaard, Klaus, Chalmer, Mona A., Kogelman, Lisette J.A., Aagaard, Bitten, Brodersen, Thorsten, Bruun, Mie Topholm, Mikkelsen, Christina, Mikkelsen, Susan, Nyegaard, Mette, Pedersen, Ole Birger, Ullum, Henrik, Sørensen, Erik, Ostrowski, Sisse Rye, Erikstrup, Christian, Hansen, Thomas Folkmann, and Hjalgrim, Henrik
- Abstract
Introduction Migraine is a prevalent neurological headache disorder. Due to challenges associated with finding effective treatment, many individuals with migraine feel compelled to explore alternative treatment strategies, such as blood donation, hypothesized to provide migraine relief. Methods Through logistic, Poisson, and Cox regression methods, we examined the links between migraine and blood donation activities in two population cohorts: Danish blood donors in the Scandinavian Donations and Transfusions Database (SCANDAT-DK, N >1 million) and the Danish Blood Donor Study (N ~ 100,000). Results SCANDAT-DK analyses showed no link between migraine and the propensity to become a blood donor among males (odds ratio [OR]Males = 0.95 [95% Confidence Interval: 0.86–1.04], and a reduced propensity among females ORFemales = 0.88 [0.83–0.93]). The incidence of migraine was not reduced upon blood donation (standardized incidence ratio [SIR]Males = 0.94 [0.83–1.06]; SIRFemales = 1.04 [0.99–1.10]). Donors with migraine demonstrated longer intervals between donations (hazard ratio [HR]Males = 0.87 [0.85–0.91], HRFemales = 0.80 [0.78–0.82]), and an increased risk of donor lapse (ORMales = 1.23 [1.14–1.32]; ORFemales = 1.28 [1.22–1.33]). Results were corroborated in DBDS using self-reported migraine. Genetic predisposition to migraine associated with longer intervals in females (HRFemales = 0.98 [0.97–0.99]), but not in males. Discussion Our findings do not support the hypothesis that blood donation serves as a viable treatment strategy among migraine patients. Future prospective investigations may help to elucidate the underlying biological mechanisms by which blood donation may influence migraine pathology., Introduction: Migraine is a prevalent neurological headache disorder. Due to challenges associated with finding effective treatment, many individuals with migraine feel compelled to explore alternative treatment strategies, such as blood donation, hypothesized to provide migraine relief. Methods: Through logistic, Poisson, and Cox regression methods, we examined the links between migraine and blood donation activities in two population cohorts: Danish blood donors in the Scandinavian Donations and Transfusions Database (SCANDAT-DK, N >1 million) and the Danish Blood Donor Study (N ~ 100,000). Results: SCANDAT-DK analyses showed no link between migraine and the propensity to become a blood donor among males (odds ratio [OR]Males = 0.95 [95% Confidence Interval: 0.86–1.04], and a reduced propensity among females ORFemales = 0.88 [0.83–0.93]). The incidence of migraine was not reduced upon blood donation (standardized incidence ratio [SIR]Males = 0.94 [0.83–1.06]; SIRFemales = 1.04 [0.99–1.10]). Donors with migraine demonstrated longer intervals between donations (hazard ratio [HR]Males = 0.87 [0.85–0.91], HRFemales = 0.80 [0.78–0.82]), and an increased risk of donor lapse (ORMales = 1.23 [1.14–1.32]; ORFemales = 1.28 [1.22–1.33]). Results were corroborated in DBDS using self-reported migraine. Genetic predisposition to migraine associated with longer intervals in females (HRFemales = 0.98 [0.97–0.99]), but not in males. Discussion: Our findings do not support the hypothesis that blood donation serves as a viable treatment strategy among migraine patients. Future prospective investigations may help to elucidate the underlying biological mechanisms by which blood donation may influence migraine pathology.
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- 2024
38. Clonal hematopoiesis and COVID-19 hospitalization in Danish adults
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Burgos Sequeros, Celia, Tulstrup, Morten, Bliddal, Sofie, Sørensen, Karina Meden, Nissen, Ioanna, Rezahosseini, Omid, Brooks, Patrick Terrence, Feenstra, Bjarke, Gang, Anne Ortved, Geller, Frank, Hald, Annemette, Harboe, Zitta Barrella, Helleberg, Marie, Jespersen, Jakob S., Lebech, Anne Mette, Lindegaard, Birgitte, Mogensen, Trine H., Møller, Maria Elizabeth Engel, Nielsen, Claus Henrik, Niemann, Carsten Utoft, Podlekareva, Daria, Sejdic, Adin, Sørensen, Erik, Teglgaard, Rebecca Svanberg, Tommerup, Niels, Weis, Nina, Brunak, Søren, Pedersen, Ole Birger Vestager, Banasik, Karina, Feldt-Rasmussen, Ulla, Nielsen, Susanne Dam, Ostrowski, Sisse Rye, Grønbæk, Kirsten, Burgos Sequeros, Celia, Tulstrup, Morten, Bliddal, Sofie, Sørensen, Karina Meden, Nissen, Ioanna, Rezahosseini, Omid, Brooks, Patrick Terrence, Feenstra, Bjarke, Gang, Anne Ortved, Geller, Frank, Hald, Annemette, Harboe, Zitta Barrella, Helleberg, Marie, Jespersen, Jakob S., Lebech, Anne Mette, Lindegaard, Birgitte, Mogensen, Trine H., Møller, Maria Elizabeth Engel, Nielsen, Claus Henrik, Niemann, Carsten Utoft, Podlekareva, Daria, Sejdic, Adin, Sørensen, Erik, Teglgaard, Rebecca Svanberg, Tommerup, Niels, Weis, Nina, Brunak, Søren, Pedersen, Ole Birger Vestager, Banasik, Karina, Feldt-Rasmussen, Ulla, Nielsen, Susanne Dam, Ostrowski, Sisse Rye, and Grønbæk, Kirsten
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- 2024
39. Trends in Lower Extremity Artery Disease Repair Incidence, Comorbidity, and Mortality: A Danish Nationwide Cohort Study, 1996–2018
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Møller,Anders, Eldrup,Nikolaj, Wetterslev,Jørn, Hellemann,Dorthe, Nielsen,Henning, Rostgaard,Klaus, Hjalgrim,Henrik, Pedersen,Ole Birger, Møller,Anders, Eldrup,Nikolaj, Wetterslev,Jørn, Hellemann,Dorthe, Nielsen,Henning, Rostgaard,Klaus, Hjalgrim,Henrik, and Pedersen,Ole Birger
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Anders Møller,1,2 Nikolaj Eldrup,3â 5 Jørn Wetterslev,6 Dorthe Hellemann,1,5 Henning Bay Nielsen,7,8 Klaus Rostgaard,9,10 Henrik Hjalgrim,5,9â 11,* Ole Birger Pedersen5,10,12,* 1Department of Anesthesia and Intensive Care, Næstved-Slagelse-Ringsted, Slagelse Hospital, Slagelse, Denmark; 2Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 3Department of Vascular Surgery, Rigshospitalet, Copenhagen, Denmark; 4Danish Vascular Registry, Aarhus, Denmark; 5Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 6Private Office, Tuborg Sundpark, Hellerup, 2900, Denmark; 7Department of Anesthesia and Intensive Care, Zealand University Hospital Roskilde, Roskilde, Denmark; 8Department of Nutrition, Exercise and Sport, Faculty of Science, University of Copenhagen, Copenhagen, Denmark; 9Danish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark; 10Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; 11Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark; 12Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark*These authors contributed equally to this workCorrespondence: Anders Møller, Department of Anesthesia and Intensive Care, Næstved-Slagelse-Ringsted Hospital, Fælledvej 11, Slagelse, DK-4200, Denmark, Tel +45 58 55 92 02, Email dr.andersm@gmail.comBackground: The prevalence of occlusive lower extremity artery disease (LEAD) is rising worldwide while European epidemiology data are scarce. We report incidence and mortality of LEAD repair in Denmark from 1996 through 2018, stratified on open aorto-iliac, open peripheral, and endovascular repair.Methods: A nationwide cohort study of prospective data from population-based Danish registers covering 1996 to 2018. Comorbidity was assessed by Charlsonâs Comorbidity Inde
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- 2024
40. Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
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Hindy, George, Tyrrell, Daniel J., Vasbinder, Alexi, Wei, Changli, Presswalla, Feriel, Wang, Hui, Blakely, Pennelope, Ozel, Ayse Bilge, Graham, Sarah, Holton, Grace H., Dowsett, Joseph, Fahed, Akl C., Amadi, Kingsley-Michael, Erne, Grace K., Tekmulla, Annika, Ismail, Anis, Launius, Christopher, Sotoodehnia, Nona, Pankow, James S., Thorner, Lise Wegner, Erikstrup, Christian, Pedersen, Ole Birger, Banasik, Karina, Brunak, Soren, Ullum, Henrik, Eugen-Olsen, Jesper, Ostrowski, Sisse Rye, Haas, Mary E., Nielsen, Jonas B., Lotta, Luca A., Engstrom, Gunnar, Melander, Olle, Orho-Melander, Marju, Zhao, Lili, Murthy, Venkatesh L., Pinsky, David J., Willer, Cristen J., Heckbert, Susan R., Reiser, Jochen, Goldstein, Daniel R., Desch, Karl C., and Hayek, Salim S.
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Immune response -- Genetic aspects ,Cell receptors -- Health aspects ,Atherosclerosis -- Genetic aspects -- Development and progression -- Care and treatment ,Health care industry - Abstract
People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly associated with cardiovascular outcomes. We assessed suPAR's pathogenic involvement in atherosclerosis using epidemiologic, genetic, and experimental approaches. We found serum suPAR levels to be predictive of coronary artery calcification and cardiovascular events in 5,406 participants without known coronary disease. In a genome-wide association meta-analysis including over 25,000 individuals, we identified a missense variant in the plasminogen activator, urokinase receptor (PLAUR) gene (rs4760), confirmed experimentally to lead to higher suPAR levels. Mendelian randomization analysis in the UK Biobank using rs4760 indicated a causal association between genetically predicted suPAR levels and atherosclerotic phenotypes. In an experimental model of atherosclerosis, proprotein convertase subtilisin/kexin-9 (Pcsk9) transfection in mice overexpressing suPAR ([suPAR.sup.Tg]) led to substantially increased atherosclerotic plaques with necrotic cores and macrophage infiltration compared with those in WT mice, despite similar cholesterol levels. Prior to induction of atherosclerosis, aortas of [suPAR.sup.Tg] mice excreted higher levels of CCL2 and had higher monocyte counts compared with WT aortas. Aortic and circulating [suPAR.sup.Tg] monocytes exhibited a proinflammatory profile and enhanced chemotaxis. These findings characterize suPAR as a pathogenic factor for atherosclerosis acting at least partially through modulation of monocyte function., Introduction People with chronic kidney disease (CKD) are disproportionately affected by cardiovascular disease (CVD), with two-thirds of patients having at least one form of CVD, atherosclerosis being the most common [...]
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- 2022
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41. Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density.
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Styrkarsdottir, Unnur, Tragante, Vinicius, Stefansdottir, Lilja, Thorleifsson, Gudmar, Oddsson, Asmundur, Sørensen, Erik, Erikstrup, Christian, Schwarz, Peter, Jørgensen, Henrik Løvendahl, Lauritzen, Jes Bruun, Brunak, Søren, Knowlton, Kirk U, Nadauld, Lincoln D, Ullum, Henrik, Pedersen, Ole Birger Vesterager, Ostrowski, Sisse Rye, Holm, Hilma, Gudbjartsson, Daniel F, Sulem, Patrick, and Stefansson, Kari
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BONE density ,BONE fractures ,DUAL-energy X-ray absorptiometry ,GENETIC variation ,VERTEBRAL fractures ,HIP fractures - Abstract
Context It is not clear if antagonizing the GIP (glucose-dependent insulinotropic polypeptide) receptor (GIPR) for treatment of obesity is likely to increase the risk of fractures, or to lower bone mineral density (BMD) beyond what is expected with rapid weight loss. Objective The objective of this study was to investigate the risk of fracture and BMD of sequence variants in GIPR that reduce the activity of the GIP receptor and have been associated with reduced body mass index (BMI). Methods We analyzed the association of 3 missense variants in GIPR , a common variant, rs1800437 (p.Glu354Gln), and 2 rare variants, rs139215588 (p.Arg190Gln) and rs143430880 (p.Glu288Gly), as well as a burden of predicted loss-of-function (LoF) variants with risk of fracture and with BMD in a large meta-analysis of up to 1.2 million participants. We analyzed associations with fractures at different skeletal sites in the general population: any fractures, hip fractures, vertebral fractures and forearm fractures, and specifically nonvertebral and osteoporotic fractures in postmenopausal women. We also evaluated associations with BMD at the lumbar spine, femoral neck, and total body measured with dual-energy x-ray absorptiometry (DXA), and with BMD estimated from heel ultrasound (eBMD). Results None of the 3 missense variants in GIPR was significantly associated with increased risk of fractures or with lower BMD. Burden of LoF variants in GIPR was not associated with fractures or with BMD measured with clinically validated DXA, but was associated with eBMD. Conclusion Missense variants in GIPR , or burden of LoF variants in the gene, are not associated with risk of fractures or with lower BMD. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Distribution of the cytochrome P450 *alleles for CYP2C9 and CYP2C19 in a cohort of the Danish Blood Donor Study determined by using the Illumina Infinium Global Screening Array.
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Jørgensen, Steffen, Brodersen, Thorsten, Vesterager Pedersen, Ole Birger, and Westergaard, Niels
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CYTOCHROME P-450 ,CYTOCHROME P-450 CYP2C19 ,BLOOD donors ,GENETIC regulation ,GENETIC variation ,CYTOCHROME c - Abstract
This article presents a study on the distribution of cytochrome P450 (CYP450) alleles in the Danish population. CYP450 enzymes are important for drug metabolism, and genetic variations in the genes encoding these enzymes can impact drug response. The study compared genotype data from different genotyping platforms and found that the CYP2C19*17 and CYP2C9*2 alleles were more common than the CYP2C19*2 and CYP2C9*3 alleles. The results provide valuable insights into the genetic variability of these enzymes in the Danish population and suggest that the Illumina GSA platform could be useful for identifying drug-gene interactions. [Extracted from the article]
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- 2024
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43. Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density
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Styrkarsdottir, Unnur, primary, Tragante, Vinicius, additional, Stefansdottir, Lilja, additional, Thorleifsson, Gudmar, additional, Oddsson, Asmundur, additional, Sørensen, Erik, additional, Erikstrup, Christian, additional, Schwarz, Peter, additional, Jørgensen, Henrik Løvendahl, additional, Lauritzen, Jes Bruun, additional, Brunak, Søren, additional, Knowlton, Kirk U, additional, Nadauld, Lincoln D, additional, Ullum, Henrik, additional, Pedersen, Ole Birger Vesterager, additional, Ostrowski, Sisse Rye, additional, Holm, Hilma, additional, Gudbjartsson, Daniel F, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
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- 2023
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44. A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy
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Skuladottir, Astros Th., Bjornsdottir, Gyda, Thorleifsson, Gudmar, Walters, G. Bragi, Nawaz, Muhammad Sulaman, Moore, Kristjan Helgi Swerford, Olason, Pall I., Thorgeirsson, Thorgeir E., Sigurpalsdottir, Brynja, Sveinbjornsson, Gardar, Eggertsson, Hannes P., Magnusson, Sigurdur H., Oddsson, Asmundur, Bjornsdottir, Anna, Vikingsson, Arnor, Sveinsson, Olafur A., Hrafnsdottir, Maria G., Sigurdardottir, Gudrun R., Halldorsson, Bjarni V., Hansen, Thomas Folkmann, Paarup, Helene, Erikstrup, Christian, Nielsen, Kaspar, Klokker, Mads, Bruun, Mie Topholm, Sorensen, Erik, Banasik, Karina, Burgdorf, Kristoffer S., Pedersen, Ole Birger, Ullum, Henrik, Jonsdottir, Ingileif, Stefansson, Hreinn, and Stefansson, Kari
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- 2021
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45. Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients
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Bliddal, Sofie, Banasik, Karina, Pedersen, Ole Birger, Nissen, Janna, Cantwell, Lisa, Schwinn, Michael, Tulstrup, Morten, Westergaard, David, Ullum, Henrik, Brunak, Søren, Tommerup, Niels, Feenstra, Bjarke, Geller, Frank, Ostrowski, Sisse Rye, Grønbæk, Kirsten, Nielsen, Claus Henrik, Nielsen, Susanne Dam, and Feldt-Rasmussen, Ulla
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- 2021
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46. Pain sensitivity in men who have never experienced a headache: an observer blinded case control study
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Olofsson, Isa Amalie, Hvedstrup, Jeppe, Falkenberg, Katrine, Chalmer, Mona Ameri, Schytz, Henrik Winther, Pedersen, Miguel Benjamin, Ullum, Henrik, Pedersen, Ole Birger, Olesen, Jes, and Hansen, Thomas Folkmann
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- 2021
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47. SMIM1 absence is associated with reduced energy expenditure and excess weight
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Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor, Jensen, Bitten Aagaard, Kaspersen, Katrine, Kjerulff, Bertram Dalskov, Kogelman, Lisette, Hørup Larsen, Margit Anita, Louloudis, Ioannis, Lundgaard, Agnete, Susan, Mikkelsen, Christina, Nissen, Ioanna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Henriksen, Alexander Pil, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Stefansson, Kari, Stefánsson, Hreinn, Sørensen, Erik, þorsteinsdóttir, Unnur, Thørner, Lise Wegner, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Katie Chan, Kei Hang, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Loz, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V.R., Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P., Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Southam, Lorraine, Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J.L., Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J.C., Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M. Arfan, Johnson, W. Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R.H.J., Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, Van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Goncalo R., Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Ida Chen, Yii-Der, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, Janaka de Silva, H., Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J. Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L.R., Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J.F., Magnusson, Patrik K.E., Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N.A., Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P. Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I.A., Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E. Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G.M., Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C.J., Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Võsa, Urmo, Burling, Keith, Walker, Lindsay, Ord, John, Barker, Peter, Warner, James, Frary, Amy, Renhstrom, Karola, Ashford, Sofie E., Piper, Jo, Biggs, Gail, Erber, Wendy N., Hoffman, Gary J., Schoenmakers, Nadia, Rieneck, Klaus, Dziegiel, Morten H., Azzu, Vian, Vacca, Michele, Aparicio, Hugo Javier, Hui, Qin, Cho, Kelly, Sun, Yan V., Wilson, Peter W., Bayraktar, Omer A., Vidal-Puig, Antonio, Ostrowski, Sisse R., Astle, William J., Olsson, Martin L., Storry, Jill R., Pedersen, Ole B., Ouwehand, Willem H., Chatterjee, Krishna, Vuckovic, Dragana, and Frontini, Mattia
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- 2024
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48. Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population
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Nissen, Janna, Trabjerg, Betina, Pedersen, MG, Banasik, Karina, Pedersen, Ole Birger, Sørensen, Erik, Nielsen, Kaspar René, Erikstrup, Christian, Petersen, Mikkel Steen, Paarup, Helene Martina, Bruun-Rasmussen, Peter, Westergaard, David, Hansen, TF, Pedersen, Carsten B., Werge, Thomas, Torrey, Fuller, Hjalgrim, Henrik, Mortensen, Preben Bo, Yolken, Robert, Brunak, Søren, Ullum, Henrik, and Burgdorf, KS
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- 2019
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49. Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
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Burgdorf, Kristoffer Sølvsten, Trabjerg, Betina B., Pedersen, Marianne Giørtz, Nissen, Janna, Banasik, Karina, Pedersen, Ole Birger, Sørensen, Erik, Nielsen, Kaspar René, Larsen, Margit Hørup, Erikstrup, Christian, Bruun-Rasmussen, Peter, Westergaard, David, Thørner, Lise Wegner, Hjalgrim, Henrik, Paarup, Helene Martina, Brunak, Søren, Pedersen, Carsten B., Torrey, E. Fuller, Werge, Thomas, Mortensen, Preben Bo, Yolken, Robert H., and Ullum, Henrik
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- 2019
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50. Obesity Variants in the GIPRGene Are not Associated With Risk of Fracture or Bone Mineral Density
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Styrkarsdottir, Unnur, Tragante, Vinicius, Stefansdottir, Lilja, Thorleifsson, Gudmar, Oddsson, Asmundur, Sørensen, Erik, Erikstrup, Christian, Schwarz, Peter, Jørgensen, Henrik Løvendahl, Lauritzen, Jes Bruun, Brunak, Søren, Knowlton, Kirk U, Nadauld, Lincoln D, Ullum, Henrik, Pedersen, Ole Birger Vesterager, Ostrowski, Sisse Rye, Holm, Hilma, Gudbjartsson, Daniel F, Sulem, Patrick, and Stefansson, Kari
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- 2024
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