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17. The efficacy of adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression: A systematic review and meta-analysis of individual participant data

Author

Driessen, Ellen, Dekker, Jack J.M., Peen, Jaap, Van, Henricus L., Maina, Giuseppe, Rosso, Gianluca, Rigardetto, Sylvia, Cuniberti, Francesco, Vitriol, Veronica G., Florenzano, Ramon U., Andreoli, Antonio, Burnand, Yvonne, López-Rodríguez, Jaime, Villamil-Salcedo, Valerio, Twisk, Jos W.R., and Cuijpers, Pim

Published
2020
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18. Interrater Reliability of the Psychological Mindedness Assessment Procedure, Extended (Dutch) Version, in a Clinical Patient Population.

Author

Segaar, Jaap, Ingenhoven, Theo, Berghuis, Han, Peen, Jaap, and Dekker, Jack

Subjects
PSYCHOLOGICAL tests, INTER-observer reliability, MENTAL health services, MENTAL health personnel, PERSONALITY disorders
Abstract

The Psychological Mindedness Assessment Procedure, Extended Dutch Version (PMAP-plus), was developed to assess psychological mindedness in mental health care. Psychological Mindedness represents the ability to understand self and others through mental representations of internal psychodynamic states. In patients, deficits in psychological mindedness capacity can cause problems in self- and interpersonal functioning. This brief report describes interrater reliability of four PMAP-plus scenarios for evaluating psychological mindedness capacity among patients. Patients with personality disorders (N = 194) were asked to respond to four enacted videotaped PMAP-plus scenarios presenting a person talking about a personal experience. The videotaped scenarios varied in their emotional impact. All verbatim responses were scored by two clinically experienced raters on a hierarchical scale with gradually increasing complexity of psychodynamic understanding. Clinicians achieved acceptable interrater reliability on PMAP-plus in this patient population. Two scenarios with low emotional impact evoked significantly higher interrater agreement as compared to two scenarios with high emotional impact. Our results suggest that mental health professionals can reliably distinguish levels of psychological mindedness by assessing PMAP-plus in a patient population. Scenarios differ in potency to reveal psychological mindedness capacity. The variation in emotional impact in subsequent scenarios makes it a promising instrument measuring psychodynamic capacities for psychotherapeutic treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Patterns of obsessive-compulsive symptoms and social functioning in schizophrenia; a replication study

Author

Swets, Marije, van Dijk, Floor A., Schirmbeck, Frederike, Peen, Jaap, de Haan, Lieuwe, Alizadeh, Behrooz Z., van Amelsvoort, Therese, Bartels-Velthuis, Agna A., van Beveren, Nico J., Bruggeman, Richard, Cahn, Wiepke, Delespaul, Philippe, Luykx, Jurjen J., Myin-Germeys, Inez, Kahn, Rene S., Simons, Claudia J.P., van Haren, Neeltje E., van Os, Jim, and van Winkel, Ruud

Published
2019
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27. Psychotherapy or medication for depression? Using individual symptom meta-analyses to derive a Symptom-Oriented Therapy (SOrT) metric for a personalised psychiatry

Author

Kappelmann, Nils, Rein, Martin, Fietz, Julia, Mayberg, Helen S., Craighead, W. Edward, Dunlop, Boadie W., Nemeroff, Charles B., Keller, Martin, Klein, Daniel N., Arnow, Bruce A., Husain, Nusrat, Jarrett, Robin B., Vittengl, Jeffrey R., Menchetti, Marco, Parker, Gordon, Barber, Jacques P., Bastos, Andre G., Dekker, Jack, Peen, Jaap, Keck, Martin E., and Kopf-Beck, Johannes

Published
2020
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29. Which patients benefit from adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression? A systematic review and meta-analysis of individual participant data.

Author

Driessen, Ellen, Fokkema, Marjolein, Dekker, Jack J. M., Peen, Jaap, Van, Henricus L., Maina, Giuseppe, Rosso, Gianluca, Rigardetto, Sylvia, Cuniberti, Francesco, Vitriol, Veronica G., Andreoli, Antonio, Burnand, Yvonne, López Rodríguez, Jaime, Villamil Salcedo, Valerio, Twisk, Jos W. R., Wienicke, Frederik J., and Cuijpers, Pim

Subjects
BRIEF psychotherapy, ANTIDEPRESSANTS, ONLINE information services, PSYCHOLOGY information storage & retrieval systems, MEDICAL databases, META-analysis, MEDICAL information storage & retrieval systems, SYSTEMATIC reviews, PSYCHODYNAMIC psychotherapy, TREATMENT effectiveness, SEVERITY of illness index, MENTAL depression, RESEARCH funding, COMBINED modality therapy, PATIENT care, MEDLINE, EVALUATION, ADULTS
Abstract

Background: Adding short-term psychodynamic psychotherapy (STPP) to antidepressants increases treatment efficacy, but it is unclear which patients benefit specifically. This study examined efficacy moderators of combined treatment (STPP + antidepressants) v. antidepressants for adults with depression. Methods: For this systematic review and meta-analysis (PROSPERO registration number: CRD42017056029), we searched PubMed, PsycINFO, Embase.com, and the Cochrane Library from inception to 1 January 2022. We included randomized clinical trials comparing combined treatment (antidepressants + individual outpatient STPP) v. antidepressants in the acute-phase treatment of depression in adults. Individual participant data were requested and analyzed combinedly using mixed-effects models (adding Cochrane risk of bias items as covariates) and an exploratory machine learning technique. The primary outcome was post-treatment depression symptom level. Results: Data were obtained for all seven trials identified (100%, n = 482, combined: n = 238, antidepressants: n = 244). Adding STPP to antidepressants was more efficacious for patients with high rather than low baseline depression levels [ B = −0.49, 95% confidence interval (CI) −0.61 to −0.37, p < 0.0001] and for patients with a depressive episode duration of >2 years rather than <1 year (B = −0.68, 95% CI −1.31 to −0.05, p = 0.03) and than 1–2 years (B = −0.86, 95% CI −1.66 to −0.06, p = 0.04). Heterogeneity was low. Effects were replicated in analyses controlling for risk of bias. Conclusions: To our knowledge, this is the first study that examines moderators across trials assessing the addition of STPP to antidepressants. These findings need validation but suggest that depression severity and episode duration are factors to consider when adding STPP to antidepressants and might contribute to personalizing treatment selection for depression. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Which patients benefit from adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression? A systematic review and meta-analysis of individual participant data

Author

Driessen, Ellen, primary, Fokkema, Marjolein, additional, Dekker, Jack J. M., additional, Peen, Jaap, additional, Van, Henricus L., additional, Maina, Giuseppe, additional, Rosso, Gianluca, additional, Rigardetto, Sylvia, additional, Cuniberti, Francesco, additional, Vitriol, Veronica G., additional, Andreoli, Antonio, additional, Burnand, Yvonne, additional, López Rodríguez, Jaime, additional, Villamil Salcedo, Valerio, additional, Twisk, Jos W. R., additional, Wienicke, Frederik J., additional, and Cuijpers, Pim, additional

Published
2022
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35. Replicating and diversifying research on therapist effects and their determinants in cognitive-behavioral and psychodynamic treatments for depression

Author

Mehta, Anuj Heena Premal, Averi Gaines, Dekker, Jack, Constantino, Michael, Frank. J. Don, Peen, Jaap, Driessen, Ellen, Coyne, Alice E., and Van, Henricus

Subjects
FOS: Psychology, Clinical Psychology, Psychology, Social and Behavioral Sciences
Abstract

This multi-part study will examine nine research questions related to therapist effects and their determinants based on data from a randomized controlled trial (RCT) that compared the efficacy of manualized cognitive behavioral therapy (CBT) versus theory-informed short psychodynamic supportive therapy (SPSP) for depression in the Netherlands (Driessen et al., 2013).

Published
2023
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42. The Association Between Loneliness and Psychiatric Symptomatology in Older Psychiatric Outpatients.

Author

Schutter, Natasja, Holwerda, Tjalling J, Kuipers, Hanna, Van, Rien H. L., Stek, Max L., Comijs, Hannie C., Peen, Jaap, and Dekker, Jack J M.

Subjects
LONELINESS, PEOPLE with mental illness, SOCIAL isolation, SOCIAL interaction, OLDER patients, SOCIAL networks
Abstract

purpose: Loneliness in adults increases with age. Although loneliness has been found to be associated with psychiatric disorders and dementia, no information is available on prevalence of loneliness in older psychiatric patients. The aims of this study were to examine prevalence of loneliness in older psychiatric outpatients, including gender differences and associations with psychiatric disorders and social isolation. Methods: Cross-sectional study in an outpatient clinic for geriatric psychiatry between September 2013 and February 2018. Interviews were done in 181 patients. Results: 80% of participants were lonely. Loneliness was associated with having contacts in less social network domains, in women but not in men. There were no associations with DSM-IV-TR-classifications. However, loneliness was associated with higher scores on questionnaires for depression and cognitive function. Intensity of treatment did not differ significantly between lonely and non-lonely participants. Conclusion: Loneliness is highly prevalent in older psychiatric outpatients, with men and women equally affected. Loneliness should be assessed in all older psychiatric patients, especially when they show high scores on symptom checklists or have a restricted social network. [ABSTRACT FROM AUTHOR]

Published
2022
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