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2. Toward Diversity-Responsive Medical Education: Taking an Intersectionality-Based Approach to a Curriculum Evaluation

Author

Muntinga, M. E., Krajenbrink, V. Q., Peerdeman, S. M., Croiset, G., and Verdonk, P.

Abstract

Recent years have seen a rise in the efforts to implement diversity topics into medical education, using either a "narrow" or a "broad" definition of culture. These developments urge that outcomes of such efforts are systematically evaluated by mapping the curriculum for diversity-responsive content. This study was aimed at using an intersectionality-based approach to define diversity-related learning objectives and to evaluate how biomedical and sociocultural aspects of diversity were integrated into a medical curriculum in the Netherlands. We took a three-phase mixed methods approach. In phase one and two, we defined essential learning objectives based on qualitative interviews with school stakeholders and diversity literature. In phase three, we screened the written curriculum for diversity content (culture, sex/gender and class) and related the results to learning objectives defined in phase two. We identified learning objectives in three areas of education (medical knowledge and skills, patient-physician communication, and reflexivity). Most diversity content pertained to biomedical knowledge and skills. Limited attention was paid to sociocultural issues as determinants of health and healthcare use. Intersections of culture, sex/gender and class remained mostly unaddressed. The curriculum's diversity-responsiveness could be improved by an operationalization of diversity that goes beyond biomedical traits of assumed homogeneous social groups. Future efforts to take an intersectionality-based approach to curriculum evaluations should include categories of difference other than culture, sex/gender and class as separate, equally important patient identities or groups.

Published
2016
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5. Procedures performed during neurosurgery residency in Europe

Author

Stienen, M. N., Freyschlag, C. F., Schaller, K., Meling, T., Al-Amin, A., Al-Mahfoudh, R., Amelot, A., Arvidsson, L., Athanasiou, A., Avellan, C. I. A., Bauchet, L., Berilazic, L., Bolger, C., Bourdillon, P., Boviatsis, S., Bozinov, O., Branco, P., Braunsdorf, W., Cahill, J., Clusmann, H., Conrad, J., Cordier, D., Cristino, N., Djilvesi, D., Duerinck, J., Dumot, C., Durak, M. A., Eisenring, C. V., Esposito, G., Finiels, P. -J., Flaskas, T., Fuentes, S., Ganau, M., Georgiadis, I., Georgiopoulos, M., Giakoumettis, D., Gilis, N., Gradil, C., Grau, S. J., Grin, A., Hadjigeorgiou, G., Halatsch, M. -E., Hecht, N., Holling, M., Ilic, R., Iken, L., Santos, N. I., Jacquesson, T., Jalloh, I., Jelaca, B., Kaestner, S., Kalasauskas, D., Kaliyev, A., Kleiber, J. -C., Konczalla, J., Kothbauer, K. F., Kovacevic, V., Krajcinovic, N., Krieg, S. M., Kamarainen, O. -P., Lapcic, M., Lapras, C., Ljungqvist, J., W. B., Lo, Lubrano, V., Majovsky, M., Manet, R., Marchi, F., Medetov, Y., Meling, T. R., Melloni, I., Melot, A., Mertens, P., Metcalfe, S., Moerkve, S. H., Mora, A. R., Musabelliu, E., Naushahi, M. J., Nurzhan, A., Omerhodzic, I., Paldor, I., Pallud, J., Papanastassiou, V., Papic, V., Paschalis, T., Payer, M., Peerdeman, S. M., Peruzzi, P., Segerlind, J. P., Posti, J. P., Proust, F., Regli, L., Rinne, J., Roche, P. -H., Rocka, S., Rotermund, R., Rutherford, S. A., Ratsep, T., Ruter, A., Saarenpaa, I. M., Samanci, M. Y., Samardzic, M., Sampron, N., Sandvik, U., Scerrati, A., Schneider, M., Schul, D. B., Sengul, G., Simon, E., Sinha, S., Solheim, O., Spatola, G., Spektor, S., Sundblom, J., Syrmos, N. C., Teo, M., Thomson, S., Tonchev, N., Tosic, L., Vandertop, W. P., von der Brelie, C., Vuk, A., Walkden, J., Wendel, C., Yaqout, M., Yusupova, M., Zollino, G., University of Zurich, Surgical clinical sciences, Neuroprotection & Neuromodulation, Neurosurgery, IOO, and ANS - Systems & Network Neuroscience

Subjects
Adult, Male, Neurosurgery/education, medicine.medical_specialty, Certification, Caseload, Europe, Neurosurgery, Residency, Training program, Working hour restriction, 610 Medicine & health, Neurosurgical Procedures, NO, 03 medical and health sciences, 10180 Clinic for Neurosurgery, 0302 clinical medicine, Surveys and Questionnaires, Germany, Medicine, Humans, Child, Greece, business.industry, Female sex, Internship and Residency, Mean age, Surgical procedures, Middle Aged, Current analysis, United Kingdom, Original Article - Neurosurgery Training, ddc:616.8, 030220 oncology & carcinogenesis, Surgery, Female, Neurology (clinical), France, business, 030217 neurology & neurosurgery, Switzerland, Demography
Abstract

Background In a previous article (10.1007/s00701-019-03888-3), preliminary results of a survey, aiming to shed light on the number of surgical procedures performed and assisted during neurosurgery residency in Europe were reported. We here present the final results and extend the analyses. Methods Board-certified neurosurgeons of European Association of Neurosurgical Societies (EANS) member countries were asked to review their residency case logs and participate in a 31-question electronic survey (SurveyMonkey Inc., San Mateo, CA). The responses received between April 25, 2018, and April 25, 2020, were considered. We excluded responses that were incomplete, from non-EANS member countries, or from respondents that have not yet completed their residency. Results Of 430 responses, 168 were considered for analysis after checking in- and exclusion criteria. Survey responders had a mean age of 42.7 ± 8.8 years, and 88.8% were male. Responses mainly came from surgeons employed at university/teaching hospitals (85.1%) in Germany (22.0%), France (12.5%), the United Kingdom (UK; 8.3%), Switzerland (7.7%), and Greece (7.1%). Most responders graduated in the years between 2011 and 2019 (57.7%). Thirty-eight responders (22.6%) graduated before and 130 responders (77.4%) after the European WTD 2003/88/EC came into effect. The mean number of surgical procedures performed independently, supervised or assisted throughout residency was 540 (95% CI 424–657), 482 (95% CI 398–568), and 579 (95% CI 441–717), respectively. Detailed numbers for cranial, spinal, adult, and pediatric subgroups are presented in the article. There was an annual decrease of about 33 cases in total caseload between 1976 and 2019 (coeff. − 33, 95% CI − 62 to − 4, p = 0.025). Variables associated with lesser total caseload during residency were training abroad (1210 vs. 1747, p = 0.083) and female sex by trend (947 vs. 1671, p = 0.111), whereas case numbers were comparable across the EANS countries (p = 0.443). Conclusion The final results of this survey largely confirm the previously reported numbers. They provide an opportunity for current trainees to compare their own case logs with. Again, we confirm a significant decline in surgical exposure during training between 1976 and 2019. In addition, the current analysis reveals that female sex and training abroad may be variables associated with lesser case numbers during residency.

Published
2020
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7. Does CSF Outflow Resistance Predict the Response to Shunting in Patients with Normal Pressure Hydrocephalus?

Author

Boon, A. J. W., Tans, J. Th. J., Delwel, E. J., Egeler-Peerdeman, S. M., Hanlo, P. W., Wurzer, J. A. L., Avezaat, C. J. J., de Jong, D. A., Gooskens, R. H. J. M., Hermans, J., Reulen, Hans-J., editor, Steiger, H.-J., editor, Marmarou, Anthony, editor, Bullock, Ross, editor, Avezaat, Cees, editor, Baethmann, Alexander, editor, Becker, Donald, editor, Brock, Mario, editor, Hoff, Julian, editor, Nagai, Hajime, editor, and Teasdale, Graham, editor

Published
1998
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8. The Effect of Intrathecal Baclofen in Dyskinetic Cerebral Palsy: The IDYS Trial

Author

Bonouvrie, Laura A., Becher, Jules G., Vles, Johan S. H., Vermeulen, R. Jeroen, Boeschoten, Karin, Geytenbeek, Johanna J. M., de Groot, Vincent, van de Pol, Laura A., van Ouwerkerk, Willem J. R., Slot, K. M., Peerdeman, S. M., Strijers, Rob L. M., Foncke, Elisabeth M. J., Twisk, Jos W. R., van de Ven, Peter, Soudant, Dan, Fleuren, Sabine, Teernstra, Onno P., MUMC+: MA Niet Med Staf Neurologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), MUMC+: MA Med Staf Spec Neurochirurgie (9), Rehabilitation medicine, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, APH - Societal Participation & Health, and Amsterdam Movement Sciences - Restoration and Development

Subjects
0301 basic medicine, Adult, Male, Baclofen, Adolescent, DYSTONIA, CHILDHOOD, CHILDREN, Placebo, Goal Attainment Scaling, law.invention, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, medicine, Humans, Young adult, VALIDITY, Adverse effect, Child, Research Articles, Injections, Spinal, Dystonia, business.industry, Muscle Relaxants, Central, Cerebral Palsy, medicine.disease, Confidence interval, PREVALENCE, LIFE, 030104 developmental biology, Treatment Outcome, Neurology, nervous system, Anesthesia, Child, Preschool, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Dyskinetic cerebral palsy, CHOREOATHETOSIS, Research Article
Abstract

Objective: Intrathecal baclofen treatment is used for the treatment of dystonia in patients with severe dyskinetic cerebral palsy; however, the current level of evidence for the effect is low. The primary aim of this study was to provide evidence for the effect of intrathecal baclofen treatment on individual goals in patients with severe dyskinetic cerebral palsy. Methods: This multicenter, randomized, double-blind, placebo-controlled trial was performed at 2 university medical centers in the Netherlands. Patients with severe dyskinetic cerebral palsy (Gross Motor Functioning Classification System level IV–V) aged 4 to 24 years who were eligible for intrathecal baclofen were included. Patients were assigned by block randomization (2:2) for treatment with intrathecal baclofen or placebo for 3 months via an implanted microinfusion pump. The primary outcome was goal attainment scaling of individual treatment goals (GAS T score). A linear regression model was used for statistical analysis with study site as a covariate. Safety analyses were done for number and type of (serious) adverse events. Results: Thirty-six patients were recruited from January 1, 2013, to March 31, 2018. Data for final analysis were available for 17 patients in the intrathecal baclofen group and 16 in the placebo group. Mean (standard deviation) GAS T score at 3 months was 38.9 (13.2) for intrathecal baclofen and 21.0 (4.6) for placebo (regression coefficient = 17.8, 95% confidence interval = 10.4-25.0, p < 0.001). Number and types of (serious) adverse events were similar between groups. Interpretation: Intrathecal baclofen treatment is superior to placebo in achieving treatment goals in patients with severe dyskinetic cerebral palsy. ANN NEUROL 2019.

Published
2019
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17. P05.65 The caregiver burden in meningioma: long-term results and its effects on caregiver’s health-related quality of life, anxiety and depression

Author

Zamanipoor Najafabadi, A H, van der Meer, P B, Boele, F W, Reijneveld, J C, Taphoorn, M J B, Klein, M, van Furth, W R, Dirven, L, and Peerdeman, S M

Subjects
Poster Presentations
Abstract

BACKGROUND: Various studies in oncological/neurological patients highlight that informal caregivers suffer from a significant disease burden. We aimed to assess the meningioma caregiver burden, and its effects on caregiver’s health-related quality of life (HRQoL), and levels of anxiety and depression. MATERIAL AND METHODS: In a multicentre cross-sectional study informal caregivers of intracranial meningioma patients at a median of 10 years after their last anti-tumour therapy were included. Informal caregivers were family members or close friends and completed the caregiver disease burden scale, SF-36 (HRQoL) and the Hospital Anxiety and Depression Scale. Caregiver burden was assessed as an independent determinant for caregiver’s HRQoL, and levels of anxiety and depression with multivariable analysis correcting for relevant confounders. Participant recruitment is still in progress. RESULTS: 110 informal caregivers were included (mean age: 64.5, female: 37.2%). Informal caregivers reported any caregiver burden in 35.2% of cases, and clinically relevant burden in 15.7%. More specifically, 20.4% of caregivers suffered from stress, 11.2% from social isolation, 13.0% from feelings of disappointment, 21.0% from emotional problems, and 12.0% from environmental factors complicating the care for the patient. The total caregiver burden score was significantly associated with decreased HRQoL on 6/8 scales and 2/2 component scores: physical function (β=-6.53, p=0.071), role limitation due to physical problems (β=-13.62, p=0.041), bodily pain (β=-13.11, p=0.014), social function (β=-11.87, p=0.001), mental health (β=-14.32, p

Published
2018

19. OS4.2 The long-term disease burden of meningioma patients: results on health-related quality of life, cognitive function, anxiety and depression

Author

Zamanipoor Najafabadi, A H, van der Meer, P B, Boele, F W, Reijneveld, J C, Taphoorn, M J B, Klein, M, van Furth, W R, Dirven, L, and Peerdeman, S M

Subjects
Oral Presentations
Abstract

BACKGROUND: Recent systematic reviews reported that meningioma patients have an impaired health-related quality of life (HRQoL) and cognitive function up to 5 years after intervention. We aimed to assess the long-term disease burden of meningioma patients. MATERIAL AND METHODS: In this multicentre cross-sectional study, intracranial meningioma patients at least 5 years (median: 9.9 years) after anti-tumour therapy were included. HRQoL was measured with the generic SF-36 (8 scales and 2 component scores) and the disease-specific EORTC QLQ-BN20 (11 scales/items), and anxiety and depression with the Hospital Anxiety and Depression Scale (HADS: ≤11/21 points is indicative for probable anxiety or depression). Six domains of cognitive function were assessed with a standardised neuropsychological test battery (z-score

Published
2018

22. Subduraal hematoom en depressie

Author

Brunekreeft, J. A., Peerdeman, S. M., Rhebergen, D., Neurosurgery, Psychiatry, and EMGO - Mental health

Abstract

Chronic subdural haematoma (CSDH) is difficult to diagnose because patients with this disorder, in particular the elderly, present with such a wide variety of symptoms. The subject of this case study is an 89-year-old man with a history of CSDH who presented with severe depressive symptoms with psychotic features and who in the end turned out to have a recurrence of CSDH. An integrated multidisciplinary approach is advocated in the case of older patients who have had a CSDH in the past and who present with psychiatric problems and fall frequently. When a patient presents with such symptoms, one needs to be on the look-out for a recurrence of CSDH.

Published
2008

23. miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo

Author

Senol, O, primary, Schaaij-Visser, T B M, additional, Erkan, E P, additional, Dorfer, C, additional, Lewandrowski, G, additional, Pham, T V, additional, Piersma, S R, additional, Peerdeman, S M, additional, Ströbel, T, additional, Tannous, B, additional, Saydam, N, additional, Slavc, I, additional, Knosp, E, additional, Jimenez, C R, additional, and Saydam, O, additional

Published
2014
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24. Neuromonitoring bij patiënten na ernstig traumatisch hersenletsel

Author

Folkersma, H, Peerdeman, S M, Visser, M C, Vriens, E M, Girbes, A R, Vandertop, W P, and Neurosurgery

Abstract

To a considerable extent, the neurological outcome of patients with severe brain trauma is determined by the primary injury caused by the accident. Substantial progress has been made in our understanding of the pathophysiological processes resulting in secondary brain damage after brain trauma, partly as a result of the introduction of advanced techniques of neuromonitoring. Early recognition and treatment of the symptoms leading to this type of brain damage seems crucial to the effort to improve the neurological outcome in these patients. Useful modern neuromonitoring techniques include: measurement of the intracranial and cerebral perfusion pressure and continuous electroencephalography. Methods that are also reliable and readily applicable, but less relevant clinically, include cerebral microdialysis of fluid from the extracellular space, determination of the parenchymal oxygen tension, and determination of the venous oxygen saturation. Other techniques that are not clinically applicable include: determination of the cerebral blood flow, the cortical tissue perfusion or the regional cerebral oxygenation.

Published
2003

25. Hypothermia

Author

Polderman, K. H., Girbes, A. R., Peerdeman, S. M., Vandertop, W. P., and Other departments

Published
2001

26. Hypothermia [1] (multiple letters)

Author

Polderman, K. H., Girbes, A. R J, Peerdeman, S. M., Vandertop, W. P., Cliffon, G. L., Intensive care medicine, ACS - Diabetes & metabolism, AII - Infectious diseases, IOO, Neurosurgery, CCA - Cancer biology and immunology, AII - Cancer immunology, CCA - Imaging and biomarkers, and CCA - Cancer Treatment and quality of life

Published
2001

28. External lumbar drainage in uncontrollable intracranial pressure in adults with severe head injury: a report of 7 cases

Author

Willemse, R B, Egeler-Peerdeman, S M, and Neurosurgery

Abstract

The retrospective results of external lumbar drainage in 7 adult patients with severe closed head injury and intracranial pressure (ICP) refractory to aggressive management strategies are presented. All patients had Glasgow Coma Scale (GCS) scores of 8 or less within 24 hours after admission and were treated by a staircase protocol including sedation, ventricular drainage, hyperventilation and mannitol. In three cases barbiturate drugs and an artificially induced hypothermia were used. Four patients required surgical evacuation of mass lesions. Three patients made a good functional recovery, 2 were severely disabled and 2 patients died. In none of the patients clinical signs of cerebral herniation occurred. We recommend additional external lumbar drainage in adults with severe head injury unresponsive to aggressive ICP control with open basilar cisterns and absent focal mass lesions on computerized-tomography scan before drainage.

Published
1998

29. Meningiomas in three male-to-female transgender subjects using oestrogens/progestogens and review of the literature.

Author

Wengel, P. V., Martin, E., Gooren, L., Den Heijer, M., and Peerdeman, S. M.

Subjects
MENINGIOMA, TRANS women, ESTROGEN, PROGESTATIONAL hormones, HORMONE therapy, PATIENTS
Abstract

Sex hormones have been proposed as a possible risk factor for the development and growth of meningiomas. Hormonal therapy plays a fundamental role in the treatment of male-to-female transgenders and needs to be continued after sex reassignment surgery. Usually, this treatment leads to no adverse events; however, its impact on hormone-related tumours such as meningiomas has not yet been investigated thoroughly. We searched our cohort of 2810 male-to-female transgender persons, who have been treated between 1975 and 2010, for patients with meningiomas. Additionally, we conducted a literature search in PubMed and EMBASE. We found three patients who developed a meningioma in male-to-female transgenders in addition to five other who have been described in the literature. These findings support the role of female sex hormones in the development and growth of meningiomas. This might be an underrepresentation, because there is no standard protocol for screening for meningiomas in this population and meningiomas can remain asymptomatic for several years. We observed regression of multiple meningiomas in one of these three cases after discontinuation of hormonal treatment. The decision to stop or continue cross-sex hormone therapy in these particular patients should be carefully reconsidered individually. [ABSTRACT FROM AUTHOR]

Published
2016
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31. Quality of Life

Author

Lucas, M. R., primary, Armstrong, T. S., additional, Acquaye, A., additional, Balachandran, D., additional, Mahajan, A., additional, Kang, D.-H., additional, Vera-Bolanos, E., additional, Gilbert, M. R., additional, Lovely, M. P., additional, Page, M., additional, Mogensen, K., additional, Arzbaecher, J., additional, Amidei, C., additional, Lupica, K., additional, Maher, M. E., additional, Sherwood, P., additional, Kagan, S., additional, Sizoo, E. M., additional, Pasman, H. R. W., additional, Reijneveld, J. C., additional, Heimans, J. J., additional, Deliens, L., additional, Taphoorn, M. J., additional, Sheth, R., additional, Bagan, B. T., additional, Baig, M. N., additional, Karas, C., additional, Jacobs, D. I., additional, Grimm, S. A., additional, Rademaker, A., additional, Rice, L., additional, Chandler, J. P., additional, Muro, K., additional, Marymount, M., additional, Helenowski, I. B., additional, Wagner, L. I., additional, Bennett, C. L., additional, Raizer, J. J., additional, Evans, A., additional, Dhall, G., additional, Finlay, J., additional, Wong, K., additional, McComb, G., additional, Soffietti, R., additional, Mueller, R. P., additional, Abacioglu, U., additional, Villa, S., additional, Fauchon, F., additional, Baumert, B., additional, Fariselli, L., additional, Tridello, G., additional, Kocher, M., additional, Bottomley, A., additional, Pendleton, C., additional, Adams, H., additional, Jallo, G. I., additional, Carson, B. S., additional, Ahn, E., additional, Quinones-Hinojosa, A., additional, Acquaye, A. A., additional, Bekele, B. N., additional, Chandler, J., additional, Nestor, V., additional, Fink, K., additional, Nashed, M., additional, Linskey, M., additional, Bota, D. A., additional, Hoeben, W., additional, Hilverda, K., additional, Postma, T. J., additional, Buter, J., additional, Lenting, J., additional, Collette, E. H., additional, Klein, M., additional, van Nieuwenhuizen, D., additional, Bosscher, L., additional, Szymanska, E., additional, Peerdeman, S. M., additional, Erdmann, T., additional, Lawrence Recht, S. N., additional, Armstrong, T., additional, Gning, I., additional, Cleeland, C., additional, Mendoza, T. R., additional, Jouniaux-Delbez, N., additional, Delattre, J. Y., additional, du Montcel, S. T., additional, Butowski, N., additional, Parvataneni, R., additional, Nicole, A., additional, Lamborn, K., additional, Polley, M., additional, Clarke, J., additional, Chang, S., additional, Prados, M., additional, Liepa, A., additional, Shi, P., additional, Thornton, D., additional, Kahlenberg, C. A., additional, Fadul, C. E., additional, Scott, R., additional, Roberts, D. W., additional, Thadani, V., additional, Bujarski, K., additional, Lallana, E. C., additional, Jobst, B. C., additional, Walker, J. G., additional, Schultz, D., additional, Grisdale, K., additional, Groves, M. D., additional, Peters, K. B., additional, Reardon, D. A., additional, Vredenburgh, J. J., additional, Desjardins, A., additional, Friedman, H. S., additional, Allen, D. H., additional, Carlson, B., additional, Neelon, V., additional, Giovanello, K., additional, Carlson, J., additional, Raynor, R., additional, Lall, R., additional, Ha, S., additional, Marymont, M., additional, Grimm, S., additional, Raizer, J., additional, and Keir, S. T., additional

Published
2010
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32. Neuro-cognitive

Author

O'Neil, S. H., primary, Azoff, J., additional, Buranahirun, C., additional, Dhall, G., additional, Panigrahy, A., additional, Borchert, M., additional, Khatua, S., additional, Ji, L., additional, Sposto, R., additional, Finlay, J., additional, Gong, X., additional, Schwartz, P., additional, Linskey, M., additional, Bota, D. A., additional, Wefel, J. S., additional, Patwardhan, S. Y., additional, Strange, C., additional, Emily, F., additional, Celine, A., additional, Penelope, K., additional, Anne-Sophie, C., additional, Rolando, D. M., additional, Michael, P., additional, Correa, D. D., additional, Shi, W., additional, Abrey, L., additional, DeAngelis, L., additional, Thaler, H., additional, Habets, E. J., additional, Walchenbach, R., additional, Kloet, A., additional, Zwinkels, H., additional, Klein, M., additional, Vecht, C. J., additional, Taphoorn, M. J., additional, Ambachtsheer, N., additional, van Nieuwenhuizen, D., additional, Heimans, J. J., additional, Reijneveld, J. C., additional, Peerdeman, S. M., additional, Lagemaat, C., additional, Peters, K. B., additional, Reardon, D. A., additional, Vredenburgh, J. J., additional, Desjardins, A., additional, Friedman, H. S., additional, Driever, P. H., additional, Koustenis, E., additional, Henze, G., additional, De Sonneville, L., additional, Rueckriegel, S. M., additional, Mok, K., additional, Klein, D., additional, Del Maestro, R., additional, Petrecca, K., additional, Olivier, A., additional, Schanker, B. D., additional, Curry, W. T., additional, Edelstein, K., additional, Spiegler, B. J., additional, Fung, S., additional, Panzarella, T., additional, Hodgson, D. C., additional, Mabbott, D. J., additional, Laperriere, N., additional, Tabori, U., additional, Bouffet, E., additional, and Mason, W. P., additional

Published
2010
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33. Radiology

Author

Ellingson, B. M., primary, Pope, W. B., additional, Lai, A., additional, Nghiemphu, P. L., additional, Cloughesy, T. F., additional, Juhasz, C., additional, Mittal, S., additional, Muzik, O., additional, Chugani, D. C., additional, Chakraborty, P. K., additional, Bahl, G., additional, Barger, G. R., additional, Carrillo, J. A., additional, Nghiemphu, P., additional, Tran, A., additional, Moftakhar, P., additional, Bruggers, C., additional, Moore, K., additional, Khatua, S., additional, Gumerlock, M. K., additional, Stolzenberg, E., additional, Fung, K.-M., additional, Smith, M. L., additional, Kedzierska, K., additional, Chacko, G., additional, Epstein, R. B., additional, Holter, J., additional, Parvataneni, R., additional, Kadambi, A., additional, Park, I., additional, Elkhaled, A., additional, Essock-Burns, E., additional, Khayal, I., additional, Butowski, N., additional, Lamborn, K., additional, Chang, S., additional, Nelson, S., additional, Sanverdi, E., additional, Ozgen, B., additional, Oguz, K. K., additional, Soylemezoglu, F., additional, Mut, M., additional, Zhu, J.-J., additional, Pfannl, R., additional, Do-Dai, D., additional, Yao, K., additional, Mignano, J., additional, Wu, J. K., additional, Linendoll, N., additional, Beal, K., additional, Chan, T., additional, Yamamda, Y., additional, Holodny, A., additional, Gutin, P. H., additional, Zhang, Z., additional, Young, R. J., additional, Lupo, J. M., additional, Cha, S., additional, Chang, S. M., additional, Nelson, S. J., additional, Laperriere, N., additional, Perry, J., additional, Macdonald, D., additional, Mason, W., additional, Easaw, J., additional, Del Maestro, R., additional, Kucharczyk, W., additional, Hussey, D., additional, Greaves, K., additional, Moore, S., additional, Pouliot, J.-F., additional, Rauschkolb, P. K., additional, Smith, S. D., additional, Belden, C. J., additional, Lallana, E. C., additional, Fadul, C. E., additional, Bosscher, L., additional, Slot, M., additional, Sanchez, E., additional, Uitdehaag, B. M., additional, Vandertop, W. P., additional, Peerdeman, S. M., additional, Blumenthal, D. T., additional, Bokstein, F., additional, Artzi, M., additional, Palmon, M., additional, Aizenstein, O., additional, Sitt, R., additional, Gurevich, K., additional, Kanner, A., additional, Ram, Z., additional, Corn, B., additional, Ben Bashat, D., additional, Martinez, N., additional, Gorniak, R., additional, Tartaglino, L., additional, Scanlan, M., additional, Glass, J., additional, Kleijn, A., additional, Chen, J. W., additional, Sun, P. Z., additional, Buhrman, J., additional, Rabkin, S. D., additional, Weissleder, R., additional, Martuza, R. L., additional, Lamfers, M. L., additional, Fulci, G., additional, Brong, K. A., additional, Hekmatyar, K., additional, Jerome, N., additional, Wilson, M., additional, Kauppinen, R. A., additional, Mok, K., additional, Valenca, M. M., additional, Sherafat, E., additional, Olivier, A., additional, Pentsova, E., additional, Rosenblum, M., additional, Palomba, L., additional, Omuro, A., additional, Murad, G. J., additional, Yachnis, A. T., additional, Dunbar, E. M., additional, Li, Y., additional, Lupo, J., additional, Polley, M.-Y., additional, Kohler, N., additional, Quisling, R., additional, Swanson, K. R., additional, Gu, S., additional, Chakraborty, G., additional, Alessio, A., additional, Claridge, J., additional, Rockne, R. C., additional, Muzi, M., additional, Krohn, K. A., additional, Spence, A. M., additional, Alvord, E. C., additional, Anderson, A. R., additional, Kinahan, P., additional, Boone, A. E., additional, Mrugala, M. M., additional, Gutova, M., additional, Khankaldyyan, V., additional, Herrmann, K. A., additional, Harutyunyan, I., additional, Abramyants, Y., additional, Annala, A. J., additional, Najbauer, J., additional, Moats, R. A., additional, Shackleford, G. M., additional, Barish, M. E., additional, and Aboody, K. S., additional

Published
2010
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34. Ongoing Clinical Trials

Author

Clarke, J. L., primary, Ennis, M. M., additional, Lamborn, K. R., additional, Prados, M. D., additional, Puduvalli, V. K., additional, Penas-Prado, M., additional, Gilbert, M. R., additional, Groves, M. D., additional, Hess, K. R., additional, Levin, V. A., additional, de Groot, J., additional, Colman, H., additional, Conrad, C. A., additional, Loghin, M. E., additional, Hunter, K., additional, Yung, W. K., additional, Chen, C., additional, Damek, D., additional, Liu, A., additional, Gaspar, L. E., additional, Waziri, A., additional, Lillehei, K., additional, Kavanagh, B., additional, Finlay, J. L., additional, Haley, K., additional, Dhall, G., additional, Gardner, S., additional, Allen, J., additional, Cornelius, A., additional, Olshefski, R., additional, Garvin, J., additional, Pradhan, K., additional, Etzl, M., additional, Goldman, S., additional, Atlas, M., additional, Thompson, S., additional, Hirt, A., additional, Hukin, J., additional, Comito, M., additional, Bertolone, S., additional, Torkildson, J., additional, Joyce, M., additional, Moertel, C., additional, Letterio, J., additional, Kennedy, G., additional, Walter, A., additional, Ji, L., additional, Sposto, R., additional, Dorris, K., additional, Wagner, L., additional, Hummel, T., additional, Drissi, R., additional, Miles, L., additional, Leach, J., additional, Chow, L., additional, Turner, R., additional, Gragert, M. N., additional, Pruitt, D., additional, Sutton, M., additional, Breneman, J., additional, Crone, K., additional, Fouladi, M., additional, Friday, B. B., additional, Buckner, J., additional, Anderson, S. K., additional, Giannini, C., additional, Kugler, J., additional, Mazurczac, M., additional, Flynn, P., additional, Gross, H., additional, Pajon, E., additional, Jaeckle, K., additional, Galanis, E., additional, Badruddoja, M. A., additional, Pazzi, M. A., additional, Stea, B., additional, Lefferts, P., additional, Contreras, N., additional, Bishop, M., additional, Seeger, J., additional, Carmody, R., additional, Rance, N., additional, Marsella, M., additional, Schroeder, K., additional, Sanan, A., additional, Swinnen, L. J., additional, Rankin, C., additional, Rushing, E. J., additional, Hutchins, L. F., additional, Damek, D. M., additional, Barger, G. R., additional, Norden, A. D., additional, Lesser, G., additional, Hammond, S. N., additional, Drappatz, J., additional, Fadul, C. E., additional, Batchelor, T. T., additional, Quant, E. C., additional, Beroukhim, R., additional, Ciampa, A., additional, Doherty, L., additional, LaFrankie, D., additional, Ruland, S., additional, Bochacki, C., additional, Phan, P., additional, Faroh, E., additional, McNamara, B., additional, David, K., additional, Rosenfeld, M. R., additional, Wen, P. Y., additional, Phuphanich, S., additional, Reardon, D., additional, Wong, E. T., additional, Plotkin, S. R., additional, Mintz, A., additional, Raizer, J. J., additional, Kaley, T. J., additional, Smith, K. H., additional, Chamberlain, M. C., additional, Graham, C., additional, Mrugala, M., additional, Johnston, S., additional, Kreisl, T. N., additional, Smith, P., additional, Iwamoto, F., additional, Sul, J., additional, Butman, J. A., additional, Fine, H. A., additional, Westphal, M., additional, Heese, O., additional, Warmuth-Metz, M., additional, Pietsch, T., additional, Schlegel, U., additional, Tonn, J.-C., additional, Schramm, J., additional, Schackert, G., additional, Melms, A., additional, Mehdorn, H. M., additional, Seifert, V., additional, Geletneky, K., additional, Reuter, D., additional, Bach, F., additional, Khasraw, M., additional, Abrey, L. E., additional, Lassman, A. B., additional, Hormigo, A., additional, Nolan, C., additional, Gavrilovic, I. T., additional, Mellinghoff, I. K., additional, Reiner, A. S., additional, DeAngelis, L., additional, Omuro, A. M., additional, Burzynski, S. R., additional, Weaver, R. A., additional, Janicki, T. J., additional, Burzynski, G. S., additional, Szymkowski, B., additional, Acelar, S. S., additional, Mechtler, L. L., additional, O'Connor, P. C., additional, Kroon, H.-A., additional, Vora, T., additional, Kurkure, P., additional, Arora, B., additional, Gupta, T., additional, Dhamankar, V., additional, Banavali, S., additional, Moiyadi, A., additional, Epari, S., additional, Merchant, N., additional, Jalali, R., additional, Moller, S., additional, Grunnet, K., additional, Hansen, S., additional, Schultz, H., additional, Holmberg, M., additional, Sorensen, M. M., additional, Poulsen, H. S., additional, Lassen, U., additional, Reardon, D. A., additional, Vredenburgh, J. J., additional, Desjardins, A., additional, Janney, D. E., additional, Peters, K., additional, Sampson, J., additional, Gururangan, S., additional, Friedman, H. S., additional, Jeyapalan, S., additional, Constantinou, M., additional, Evans, D., additional, Elinzano, H., additional, O'Connor, B., additional, Puthawala, M. Y., additional, Goldman, M., additional, Oyelese, A., additional, Cielo, D., additional, Dipetrillo, T., additional, Safran, H., additional, Anan, M., additional, Seyed Sadr, M., additional, Alshami, J., additional, Sabau, C., additional, Seyed Sadr, E., additional, Siu, V., additional, Guiot, M.-C., additional, Samani, A., additional, Del Maestro, R., additional, Bogdahn, U., additional, Stockhammer, G., additional, Mahapatra, A. K., additional, Venkataramana, N. K., additional, Oliushine, V. E., additional, Parfenov, V. E., additional, Poverennova, I. E., additional, Hau, P., additional, Jachimczak, P., additional, Heinrichs, H., additional, Schlingensiepen, K.-H., additional, Shibui, S., additional, Kayama, T., additional, Wakabayashi, T., additional, Nishikawa, R., additional, de Groot, M., additional, Aronica, E., additional, Vecht, C. J., additional, Toering, S. T., additional, Heimans, J. J., additional, Reijneveld, J. C., additional, Batchelor, T., additional, Mulholland, P., additional, Neyns, B., additional, Nabors, L. B., additional, Campone, M., additional, Wick, A., additional, Mason, W., additional, Mikkelsen, T., additional, Ashby, L. S., additional, DeGroot, J. F., additional, Gattamaneni, H. R., additional, Cher, L. M., additional, Rosenthal, M. A., additional, Payer, F., additional, Xu, J., additional, Liu, Q., additional, van den Bent, M., additional, Nabors, B., additional, Fink, K., additional, Chan, M., additional, Trusheim, J., additional, Raval, S., additional, Hicking, C., additional, Henslee-Downey, J., additional, Picard, M., additional, Schiff, D., additional, Karimi, S., additional, DeAngelis, L. M., additional, Nolan, C. P., additional, Omuro, A., additional, Gavrilovic, I., additional, Norden, A., additional, Purow, B. W., additional, Lieberman, F. S., additional, Hariharan, S., additional, Perez-Larraya, J. G., additional, Honnorat, J., additional, Chinot, O., additional, Catry-Thomas, I., additional, Taillandier, L., additional, Guillamo, J. S., additional, Campello, C., additional, Monjour, A., additional, Tanguy, M. L., additional, Delattre, J. Y., additional, Franz, D. N., additional, Krueger, D. A., additional, Care, M. M., additional, Holland-Bouley, K., additional, Agricola, K., additional, Tudor, C., additional, Mangeshkar, P., additional, Byars, A. W., additional, Sahmoud, T., additional, Alonso-Basanta, M., additional, Lustig, R. A., additional, Dorsey, J. F., additional, Lai, R. K., additional, Recht, L. D., additional, Paleologos, N., additional, Groves, M., additional, Meech, S., additional, Davis, T., additional, Pavlov, D., additional, Marshall, M. A., additional, Slot, M., additional, Peerdeman, S. M., additional, Beauchesne, P. D., additional, Faure, G., additional, Noel, G., additional, Schmitt, T., additional, Kerr, C., additional, Jadaud, E., additional, Martin, L., additional, Carnin, C., additional, Peters, K. B., additional, Herndon, J. E., additional, Kirkpatrick, J. P., additional, Nayak, L., additional, Panageas, K. S., additional, and Deangelis, L. M., additional

Published
2010
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36. TE SLAP VAN HET LACHEN

Author

Egeler-Peerdeman, S. M., Visscher, F., Taphoorn, M. J.B., Neurosurgery, AII - Cancer immunology, CCA - Cancer biology and immunology, and Neurology

Published
1990

41. Acquired encephaloceles and epilepsy in osteopetrosis.

Author

Mandl, E. S., Buis, D. R., Heimans, J. J., and Peerdeman, S. M.

Subjects
ENCEPHALOCELE, EPILEPSY, OSTEOPETROSIS, BONE resorption, OSTEOCLASTS, BONE diseases
Abstract

Osteopetrosis is a condition in which there is a defect in bone resorption by osteoclasts. With thickening of the skull and skull base, the cranial capacity becomes compromised and skull foramina gradually occlude, resulting in a wide range of neurological symptoms and signs. We present a case of autosomal dominant osteopetrosis with temporal lobe epilepsy and nasal obstruction due to acquired bifrontal encephaloceles associated with a decreased intracranial capacity. Neurosurgical reconstruction of the frontal skull base alleviated the symptoms of epilepsy and nasal obstruction. [ABSTRACT FROM AUTHOR]

Published
2007
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45. Effects of physician-based emergency medical service dispatch in severe traumatic brain injury on prehospital run time.

Author

Franschman G, Verburg N, Brens-Heldens V, Andriessen TM, Van der Naalt J, Peerdeman SM, Valk JP, Hoogerwerf N, Greuters S, Schober P, Vos PE, Christiaans HM, and Boer C

Subjects
Adult, Air Ambulances, Brain Injuries complications, Brain Injuries epidemiology, Female, Glasgow Coma Scale, Guideline Adherence, Humans, Injury Severity Score, Male, Outcome Assessment, Health Care, Practice Guidelines as Topic, Prognosis, Retrospective Studies, Time Factors, Workforce, Brain Injuries therapy, Emergency Medical Services organization & administration, Intubation, Intratracheal methods, Physicians
Abstract

Introduction: Prehospital care by physician-based helicopter emergency medical services (P-HEMS) may prolong total prehospital run time. This has raised an issue of debate about the benefits of these services in traumatic brain injury (TBI). We therefore investigated the effects of P-HEMS dispatch on prehospital run time and outcome in severe TBI., Methods: Prehospital run times of 497 patients with severe TBI who were solely treated by a paramedic EMS (n = 125) or an EMS/P-HEMS combination (n = 372) were retrospectively analyzed. Other study parameters included the injury severity score (ISS), Glasgow Coma Scale (GCS), prehospital endotracheal intubation and predicted and observed outcome rates., Results: Patients who received P-HEMS care were younger and had higher ISS values than solely EMS-treated patients (10%; P = 0.04). The overall prehospital run time was 74 ± 54 min, with similar out-of-hospital times for EMS and P-HEMS treated patients. Prehospital endotracheal intubation was more frequently performed in the P-HEMS group (88%) than in the EMS group (35%; P<0.001). The prehospital run time for intubated patients was similar for P-HEMS (66 (51-80)min) and EMS-treated patients (59 (41-88 min). Unexpectedly, mortality probability scores and observed outcome scores were less favourable for EMS-treated patients when compared to patients treated by P-HEMS., Conclusion: P-HEMS dispatch does not increase prehospital run times in severe TBI, while it assures prehospital intubation of TBI patients by a well-trained physician. Our data however suggest that a subgroup of the most severely injured patients received prehospital care by an EMS, while international guidelines recommend advanced life support by a physician-based EMS in these cases., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Published
2012
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46. Feasibility of online seizure detection with continuous EEG monitoring in the intensive care unit.

Author

Ponten SC, Ronner HE, Strijers RL, Visser MC, Peerdeman SM, Vandertop WP, Beishuizen A, Girbes AR, and Stam CJ

Subjects
Aged, Brain physiopathology, Coma physiopathology, Female, Humans, Male, Middle Aged, Monitoring, Physiologic methods, Prospective Studies, Seizures physiopathology, Electroencephalography methods, Intensive Care Units, Seizures diagnosis
Abstract

Introduction: Continuous EEG (cEEG) is of great interest in view of the reported high prevalence of non-convulsive seizures on intensive care units (ICUs). Here, we describe our experiences applying a seizure warning system using cEEG monitoring., Methods: Fifty comatose ICU patients were included prospectively and monitored. Twenty-eight patients had post-anoxic encephalopathy (PAE) and 22 had focal brain lesions. A measure of neuronal interactions, synchronization likelihood, was calculated online over 10s EEG epochs and instances when the synchronization likelihood exceeded a threshold where marked as seizures., Results: Five patients developed seizures. Our method detected seizures in three patients, in the other patients seizures were missed because of they were non-convulsive and had a focal character. The average false positive rate was 0.676/h., Discussion: This is our first attempt to implement online seizure detection in the ICU. Despite problems with artifacts and that we missed focally oriented seizures, we succeeded in monitoring patients online. Given the relatively high occurrence of seizures, online seizure detection with cEEG merits further development for use in ICUs., (Copyright © 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.)

Published
2010
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47. Prehospital endotracheal intubation in patients with severe traumatic brain injury: guidelines versus reality.

Author

Franschman G, Peerdeman SM, Greuters S, Vieveen J, Brinkman AC, Christiaans HM, Toor EJ, Jukema GN, Loer SA, and Boer C

Subjects
Brain Injuries physiopathology, Female, Glasgow Coma Scale, Humans, Male, Middle Aged, Practice Guidelines as Topic, Prognosis, Brain Injuries therapy, Emergency Medical Services, Guideline Adherence, Intubation, Intratracheal statistics & numerical data
Abstract

The international Brain Trauma Foundation guidelines recommend prehospital endotracheal intubation in all patients with traumatic brain injury (TBI) and a Glasgow Coma Scale (GCS)< or =8. Close adherence to these guidelines is associated with improved outcome, but not all severely injured TBI patients receive adequate prehospital airway support. Here we hypothesized that guideline adherence varies when skills are involved that rely on training and expertise, such as endotracheal intubation. We retrospectively studied the medical records of CT-confirmed TBI patients with a GCS< or =8 who were referred to a level 1 trauma centre in Amsterdam (n=127). Records were analyzed for demographic parameters, prehospital treatment modalities, involvement of an emergency medical service (EMS) and respiratory and metabolic parameters upon arrival at the hospital. Patients were mostly male, aged 45+/-21 years with a median injury severity score (ISS) of 26. Of all patients for whom guidelines recommend endotracheal intubation, only 56% were intubated. In 21 out of 106 severe cases an EMS was not called for, suggesting low guideline adherence. Especially those TBI patients treated by paramedics tended to develop higher levels of stress markers like glucose and lactate. We observed a low degree of adherence to intubation guidelines in a Dutch urban area. Main reasons for low adherence were the unavailability of specialized care, scoop and run strategies and absence of a specialist physician in cases where intubation was recommended. The discrepancy between guidelines and reality warrants changing practice to improve guideline compliance and optimize outcome in TBI patients.

Published
2009
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48. [Subdural hematoma and depression].

Author

Brunekreeft JA, Peerdeman SM, and Rhebergen D

Subjects
Accidental Falls, Aged, 80 and over, Diagnosis, Differential, Hematoma, Subdural, Chronic pathology, Hematoma, Subdural, Chronic psychology, Humans, Male, Recurrence, Depression diagnosis, Hematoma, Subdural, Chronic diagnosis
Abstract

Background: Chronic subdural haematoma (csdh) is difficult to diagnose because patients with this disorder, in particular the elderly, present with such a wide variety of symptoms. The subject of this case study is an 89-year-old man with a history of csdh who presented with severe depressive symptoms with psychotic features and who in the end turned out to have a recurrence of csdh. An integrated past and who present with psychiatric problems and fall frequently. When a patient presents with such symptoms, one needs to be on the look-out for a recurrence of csdh.

Published
2008

49. Cerebral microdialysis and positron emission tomography after surgery for aneurysmal subarachnoid hemorrhage in grade I patients.

Author

Noske DP, Peerdeman SM, Comans EF, Dirven CM, Knol DL, Girbes AR, and Vandertop WP

Subjects
Adult, Aged, Brain Chemistry, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Radiopharmaceuticals, Reference Values, Glucose metabolism, Intracranial Aneurysm complications, Microdialysis, Positron-Emission Tomography, Subarachnoid Hemorrhage diagnostic imaging, Subarachnoid Hemorrhage surgery
Abstract

Background: Using cerebral microdialysis, baseline values for energy-related chemical markers have been reported in awake patients. Radionuclide studies have demonstrated a locally decreased metabolism, thought to be the result of brain retraction. These baseline values, however, may not be applicable to patients after surgical aneurysm repair following a subarachnoid hemorrhage (SAH). We assessed metabolic chemical marker levels in World Federation of Neurological Surgeons Committee (WFNS) grade I SAH patients after aneurysm surgery and compared them with previously reported baseline values., Methods: In 5 WFNS grade I SAH patients, energy-related chemical marker levels were obtained using microdialysis in the area of brain retraction after aneurysm surgery. In addition, an [(18)F]2-deoxy-d-glucose positron emission tomography (FDG-PET) was performed., Results: The FDG-PET showed a decrease of glucose metabolism in the frontotemporal area. Comparing the mean values for chemical markers of this study with reported baseline values, the most striking difference was a mild decrease of pyruvate and an increase of the lactate/pyruvate ratio. In individual patients, some markers indicated possible ischemia. A consistent pattern or ischemic profile for all markers, however, was not found., Conclusion: FDG-PET scanning confirmed postoperative metabolic changes found in previous studies. Mean interstitial chemical marker levels ranged from normal to mildly deviant compared with reference chemical marker levels for awake patients and are likely to be applicable in SAH patients after aneurysm repair.

Published
2005
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50. [Neuromonitoring of patients following severe brain trauma].

Author

Folkersma H, Peerdeman SM, Visser MC, Vriens EM, Girbes AR, and Vandertop WP

Subjects
Brain Damage, Chronic prevention & control, Cerebrovascular Circulation physiology, Humans, Intracranial Pressure physiology, Monitoring, Physiologic, Prognosis, Brain Injuries physiopathology
Abstract

To a considerable extent, the neurological outcome of patients with severe brain trauma is determined by the primary injury caused by the accident. Substantial progress has been made in our understanding of the pathophysiological processes resulting in secondary brain damage after brain trauma, partly as a result of the introduction of advanced techniques of neuromonitoring. Early recognition and treatment of the symptoms leading to this type of brain damage seems crucial to the effort to improve the neurological outcome in these patients. Useful modern neuromonitoring techniques include: measurement of the intracranial and cerebral perfusion pressure and continuous electroencephalography. Methods that are also reliable and readily applicable, but less relevant clinically, include cerebral microdialysis of fluid from the extracellular space, determination of the parenchymal oxygen tension, and determination of the venous oxygen saturation. Other techniques that are not clinically applicable include: determination of the cerebral blood flow, the cortical tissue perfusion or the regional cerebral oxygenation.

Published
2003

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