1. The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells.
- Author
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Martin TJ, Gabure S, Maise J, Snipes S, Peete M, and Whalen MM
- Subjects
- Adult, Cell Survival drug effects, Cells, Cultured, Humans, Leukocytes, Mononuclear metabolism, DDT toxicity, Interleukin-6 metabolism, Leukocytes, Mononuclear drug effects, Pentachlorophenol toxicity, Pesticides toxicity
- Abstract
The environmental contaminants pentachlorophenol (PCP) and 4, 4'-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 μM (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulated stimulates inflammatory diseases and tumor progression. Immune cells exposed to PCP at 0.05-5 μM and DDT at 0.025-2.5 μM showed increased secretion of IL-6 when the cell preparations contained either T lymphocytes or monocytes. Increased IL-6 secretion was due to PCP and DDT induced cellular production of the cytokine and was dependent on MAP kinase signaling pathways (in the case of PCP). Compound-induced increases in IL-6 production were in part due to increases in either the transcription of and/or stability of its mRNA. Thus, both PCP and DDT have the potential to produce chronic inflammation by stimulating production of IL-6 by immune cells., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
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