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ZWINT plays an important role in regulating the mitotic checkpoint and cell cycle, and is closely associated with tumor proliferation and migration. Recent studies have shown that high ZWINT expression is associated with poor prognosis in patients with lung adenocarcinoma(LUAD) and Glioblastoma (GBM). Previous analyses of ZWINT were limited to a certain type of cancer, but there has not been a systematic pan-cancer study of ZWINT. We used the TCGA (The Cancer Genome Atlas) project and GTEx data (Genotype-Tissue Expression) to analyze ZWINT expression levels and the correlation with cancer survival prognosis. To understand the underlying biological mechanisms of ZWINT and its relevance to immune infiltration, we systematically analyzed ZWINT-associated genetic alterations, immune infiltration and gene enrichment analysis with different bioinformatics methods. Our study showed that ZWINT mRNA expression was elevated in most human tumors and was significantly increased in the early stages of cancer compared to ZWINT expression in normal tissues.ZWINT high expression is significantly correlated with poor prognosis in most tumors. ZWINT is extensively involved in immune infiltration of tumors. Single cell sequencing data showed that ZWINT was significantly associated with cell cycle, DNA repair, DNA damage, and proliferation. Thus, ZWINT expression correlates with prognosis and immune infiltration in tumor patients. ZWINT may be a potential biomarker for prognosis and an important target for tumor immunotherapy.

Objective. To analyze the effectiveness of nursing risk management in neonatal asphyxia resuscitation care and to observe and summarize the nursing measures and outcomes. Methods. A total of 60 neonatal asphyxia cases from January 2021 to December 2021 were recruited and assigned via a random number table method at a ratio of 1 : 1 to receive either routine care plus nursing risk management (the observation group, n = 30) or routine care (the control group, n = 30). Outcome measures included blood gas index, neonatal Apgar score, neonatal behavioral neurological assessment (NBNA) score, nursing satisfaction, and complications. Results. The differences in partial pressure of oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2) between the two groups before care were not statistically significant ( P > 0.05 ), while after care, PaO2 in the observation group had a higher level of PaO2 and a lower level of PaCO2 than the control group ( P < 0.01 ). The two groups showed similar Apgar scores and NBNA scores before care ( P > 0.05 ), while after care, routine care plus nursing risk management resulted in higher Apgar scores and NBNA scores versus routine care alone ( P < 0.01 ). The nursing satisfaction rate in the observation group (96.67%) was significantly higher than that of the control group (73.33%) ( P = 0.030 ). Nursing risk management plus routine care was associated with a significantly lower incidence of complications (6.67%) compared to routine care (26.67%) ( P = 0.038 ). Conclusion. Nursing risk management in neonatal asphyxia resuscitation care showed outstanding outcomes in improving neonatal blood gas index, neurological function, and Apgar score, while reducing the occurrence of complications and achieving high nursing satisfaction.

Two kinds of asphalt pavement with thick asphalt layers were used to construct two samples. In structure I, a semirigid base and graded crushed stone subbase were used. In structure II, a granular base and semirigid subbase layer were used. Responses of the two structures under traffic loads were measured using optical fiber sensors, and the differences between theoretical model results and field measurements were analyzed. Field measurements show that vertical compressive stress in structure I is larger than that in structure II. The maximum tensile strain of the asphalt layer is located at the bottom of the AC-25C layer in structure I and at the bottom of the AC-25F layer in structure II. The latter is significantly larger than the former, indicating the possibility of fatigue cracking induced by traffic load is higher in structure II. The measured tensile horizontal strain at the bottom of the semirigid layer is relatively low (<30εμ) in both structure I and structure II. In theoretical model, static modulus, dynamic modulus, and interface bonding ability are considered and theoretical responses are calculated. There are significant differences between the theoretical results and field test data. In the theoretic model, the material properties of layers and bonding status of adjacent layers all influence the results. In order to reduce the difference between the calculated and measured results, numerous material tests and field tests should be carried out.

Three 2-phenyl-1,3-diazaazulene derivatives were synthesized and their protonation behaviours were investigated systematically via UV–vis absorption titration and 1H NMR titration, as well as theoretical calculations. One of them exhibited a monoprotonation process while the others displayed prominent halochromic diprotonation responses. Interestingly, upon protonation of 2-phenyl-1,3-diazaazulene derivatives, the coplanarity and conjugation of the 16-π-conjugated backbones were well kept, while the electronic structures were controllably adjusted. The response mechanism of 1,3-diazaazulene derivatives towards acid is through the attachment of acid proton to the nitrogen atom in the diazaazulene ring, resulting in the change of the hybridization of protonated-N from sp2 to sp3, which differed from that of the well-known azulene (analogue of 1,3-diazaazulene, protonation at carbon atom). This work would provide a new insight into the protonation research of the organic functional molecules.

A dimerized 1,3-diazaazulene derivative, namely 1,4-bis(1,3-diazaazulen-2-yl)benzene [or 2,2′-(1,4-phenylene)bis(1,3-diazaazulene)], C22H14N4, (I), has been synthesized successfully through the condensation reaction between 2-methoxytropone and benzene-1,4-dicarboximidamide hydrochloride, and was characterized by 1H NMR and 13C NMR spectroscopies, and ESI–MS. X-ray diffraction analysis reveals that (I) has a nearly planar structure with good π-electron delocalization, indicating that it might serve as a π building block. The crystal belongs to the monoclinic system. One-dimensional chains were formed along the a axis through π–π interactions and adjacent chains are stabilized by C—H...N interactions, forming a three-dimensional architecture. The solid emission of (I) in the crystalline form exhibited a 170 nm red shift compared with that in the solution state. The observed optical bandgap for (I) is 3.22 eV and a cyclic voltammetry experiment confirmed the energy levels of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO). The calculated bandgap for (I) is 3.37 eV, which is very close to the experimental result. In addition, the polarizability and hyperpolarizability of (I) were appraised for its further application in second-order nonlinear optical materials.

Industrialized and intensive aquaculture mode is the development direction of aquaculture in China. Water quality monitoring is the key to realize the modernization of aquaculture. In this paper, in accordance with the policy requirements of national science and technology to promote agriculture, A new water quality monitoring system is designed, which integrates GIS and internet of things technology. Through the control of water temperature, dissolved oxygen, pH and other data, the remote monitoring and management of water environment can be achieved, and the aquaculture environment can be effectively controlled, so that aquatic products can survive in the most suitable environment.

For improve the efficiency and accuracy of Chinese text categorization, this paper presents a new Chinese text classier, in which word segmentation system is based on forward scan corpus, and word frequency statistics method is different in the training stage and the test stage, after that, a novel feature selection is proposed according to word frequency, mutual information and classificatory information, Finally a fast Bayes theory classier is designed. Experiments prove this classier is simple and effective.

Organic–inorganic hybrid perovskite solar cells have achieved great success in recent years. Meanwhile, inverted structured device is an important branch in perovskite photovoltaics owing to its peculiar advantages of low-temperature fabrication process and non-hysteresis behavior. In this kind of device, the electron transport material, as well as the interface between perovskite and electron transport layer (ETL), plays a crucial role in photoelectric conversion process. We report that the utilization of the fullerene derivative blend, PCBM and its dumb-belled dimer, as electron transport material in inverted perovskite solar cells, which could significantly enhance the photovoltaic performances. The morphology of ETL can be regulated by changing the admixing ratio of PCBM and its dimer. Moreover, the steady-state/time-resolved fluorescence and transient photovoltage decay measurements indicate that the optimization of perovskite/ETL interface through an appropriate fullerene blend is beneficial to promote charge separation and suppress charge recombination.

Aiming at the text document similarity and initial center point problems of K-means algorithm, a new model is proposed, in which used a new method of Frequency-Sorted Term Vector Model(FSTVM) to represent a document, and for reducing the dimension of a document designed an automatic method to filter commonly used words, and redesigned the similarity calculation formula and optimization algorithm for the initial center. Compared with the traditional algorithms, the new proposed algorithm can get initial centers with higher quality and steadier cluster results, Experimental results prove this clustering algorithm is simple and effective.

In this paper, a medical image enhancement and 3D reconstruction system is proposed, which uses the processing and analysis of a series of 2D CT image to convert 3D model. The system is developed in the OS of Window8, and uses Microsoft Visual Studio 2012 as the development tool in which includes MFC class library and DirectX. The whole system is completely developed in the c++ language, which can propose a set of image intensification algorithm to enhance the images visual effect and surgery precision, and draw 3D human organ directly. At last, the experimental results made for the prototype illustrate the system well. This research will lay a good foundation for the development of medical image 3D reconstruction.

Objective Community health services are an emerging trend. We have found in practice that diagnosis and treatment of respiratory diseases in the community are distinct. The respiratory department’s daily work involves a number of outpatient registration items and a vast workload. The routine manual operation is inefficient and it is not convenient to make effective statistical analysis of the outpatient data to identify the risk factors closely related to diseases. Therefore, it is imperative to process the outpatient information of patients with respiratory diseases effectively and efficiently in a unified manner by means of computer technology. Methods The design and realization of the Community Health Service-oriented computer-assisted Information System for Diagnosis and Treatment of Respiratory Diseases (CHS-DTRD) was completed as part of the community intervention study on bronchial asthma that was carried out jointly by the Nanjing First Hospital Affiliated to Nanjing Medical University and the Hospital of Nanjing University of Science & Technology, and based on 2 years of experience and the needs of an overall analysis. Results The computer-assisted information system for diagnosis and treatment was developed using Java Server Page (JSP) technology and introducing the advanced Asynchronous JavaScript XML (AJAX) technique and MS-SQL Server was used in the background database. CHS-DTRD was composed of eight functional modules (outpatient data maintenance, outpatient appointment, intelligent analysis for disease risk factors, query and statistics, data dictionary maintenance, database manipulation, access control, and system configuration). CHS-DTRD featured a friendly interface, convenient operation, and stability and reliability. Conclusion Community health-oriented diagnosis and treatment of respiratory diseases is simple, programmable, and intuitive, thus the workload of physicians is significantly reduced and the work efficiency is improved. This system facilitates an intelligent analysis of disease risk factors using data mining technology, and provides physicians with suggestions on intelligent analysis for diagnosis of disease and conclusion of disease causes.

Background: YKL-40, a novel COPD biomarker, participates in inflammatory responses and promotes angiogenesis. This study aimed to evaluate the correlations of serum YKL-40 levels with clinical disease severity and laboratory parameters of COPD and to assess the associations of YKL-40 with IL-6 and VEGF. Method: The circulating YKL-40, IL-6, and VEGF levels in 40 stable COPD patients, 40 acutely exacerbated COPD patients and 20 healthy subjects were measured via ELISA. Radiological examination (CT emphysema index) and lung function parameters were examined to assess disease severity. Symptoms (mMRC, CAT), BMI, frequency of COPD exacerbations, smoking burden, and laboratory parameters such as CRP levels and peripheral blood neutrophil cell counts were recorded. Results: The serum YKL-40, IL-6, and VEGF levels were significantly higher in COPD patients than in controls (p 2 , CAT score≥10, ≥2 exacerbations per year or smoking index>10 pack-years. In stable COPD patients, YKL-40 negatively correlated with FEV 1 % (r=-0.503, p=0.005) and MVV%(r=-0.463, p=0.010), positively correlated with LAA% (r=0.452, p=0.03),but not with the DCLOc%. Conclusions: The circulating YKL-40 level strongly reflects inflammation and disease severity and negatively correlates with pulmonary ventilation function in COPD patients. These findings suggest a novel role of YKL-40 in COPD management.

Objective: To investigate the feasibility of a non-stimulation needle with an external indwelling cannula for upper-limb surgery and acute postoperative pain management. Methods: 62 patients undergoing either scheduled or emergency upper-limb surgery received brachial plexus block of modified interscalene or axillary brachial and then postoperative patient-controlled analgesia (PCA) with local analgesics using a specially designed non-stimulation needle with an external indwelling cannula. The outcome measurements included anesthetic effect, acute or chronic complications, postoperative analgesic effect and patient's satisfaction. Results: The success rate of anesthesia was 96.8%. The single attempt placement with the external indwelling cannula was achieved in 85.2% of patients with axillary brachial plexus block and 78.8% with modified interscalene brachial plexus block. The incidence of severe intoxication was 3.7% with axillary brachial plexus block and 3.0% with modified interscalene brachial plexus block. No hematoma at the injection site, Horner's syndrome, hoarseness or dyspnea was observed. Postoperative analgesic effect was achieved in 100% and activities were slightly lowered in 91.7%. The incidence of nausea and vomit was 8.3%; patient's satisfaction was 9.1 on a 10-point scale system. Infection, nerve injury and respiratory depression were absent during the catheter indwelling. The indwelling time of external indwelling cannula was 30.5 h on average. There was no nerve injury related complication after withdrawing the external indwelling catheter. Conclusions: Brachial plexus block using a non-stimulation needle with an external indwelling cannula has favorable intra-operative anesthetic benefit and provides an excellent postoperative analgesic outcome. The low incidence of complications and favorable patient's satisfaction suggest that non-stimulation needle with an external indwelling cannula is a useful and safe anesthetic tool in brachial nerve block and acute postoperative pain management.

Objective: To investigate the feasibility of a non-stimulation needle with an external indwelling cannula for upper-limb surgery and acute postoperative pain management. Methods: 62 patients undergoing either scheduled or emergency upper-limb surgery received brachial plexus block of modified interscalene or axillary brachial and then postoperative patient-controlled analgesia (PCA) with local analgesics using a specially designed non-stimulation needle with an external indwelling cannula. The outcome measurements included anesthetic effect, acute or chronic complications, postoperative analgesic effect and patient's satisfaction. Results: The success rate of anesthesia was 96.8%. The single attempt placement with the external indwelling cannula was achieved in 85.2% of patients with axillary brachial plexus block and 78.8% with modified interscalene brachial plexus block. The incidence of severe intoxication was 3.7% with axillary brachial plexus block and 3.0% with modified interscalene brachial plexus block. No hematoma at the injection site, Horner's syndrome, hoarseness or dyspnea was observed. Postoperative analgesic effect was achieved in 100% and activities were slightly lowered in 91.7%. The incidence of nausea and vomit was 8.3%; patient's satisfaction was 9.1 on a 10-point scale system. Infection, nerve injury and respiratory depression were absent during the catheter indwelling. The indwelling time of external indwelling cannula was 30.5 h on average. There was no nerve injury related complication after withdrawing the external indwelling catheter. Conclusions: Brachial plexus block using a non-stimulation needle with an external indwelling cannula has favorable intra-operative anesthetic benefit and provides an excellent postoperative analgesic outcome. The low incidence of complications and favorable patient's satisfaction suggest that non-stimulation needle with an external indwelling cannula is a useful and safe anesthetic tool in brachial nerve block and acute postoperative pain management.

In order to study the uniaxial loading failure process of pervious concrete and the influence of water-cement ratio and loading rate on the compressive strength, we carry out indoor uniaxial compression test and establish parallel bond model by discrete element program PFC2D to analysis from the angle of micro. By comparing the indoor test data with discrete element simulation results, we found that the compressive strength of pervious concrete increased with the increase of water cement ratio, and there is a difference between the state of failure and the distribution of cracks. With the increase of loading rate, the compressive strength of pervious concrete is improving, the corresponding peak point strain is reducing, the number of microscopic cracks is decreasing, and the degree of breakage is reducing.

The measurement of hydrogen peroxide (H(2)O(2)) in exhaled breath condensate (EBC) has been proposed as a noninvasive way of monitoring airway inflammation. However, results from individual studies on EBC H(2)O(2) evaluation of asthma are conflicting. The purpose of this study was to explore whether EBC H(2)O(2) is elevated in people with asthma and whether it reflects disease severity and disease control or responds to corticosteroid treatment.Studies were identified by searching PubMed, Embase, Cochrane Database, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and www.controlled-trials.com for relevant reports published before September 2010. Observational studies comparing levels of EBC H(2)O(2) between patients with asthma who were nonsmokers and healthy subjects were included. Data were independently extracted by two investigators and analyzed using Stata 10.0 software.Eight studies (involving 728 participants) were included. EBC H(2)O(2) concentrations were significantly higher in patients with asthma who were nonsmokers compared with healthy subjects, and higher values of EBC H(2)O(2) were observed at each level of asthma, classified either by severity or control level, and the values were negatively correlated with FEV(1). In addition, EBC H(2)O(2) concentrations were lower in patients with asthma treated with corticosteroids than in patients with asthma not treated with corticosteroids.H(2)O(2) might be a promising biomarker for guiding asthma treatment. However, further investigation is needed to establish its role.

A conceptual medical robotic system applicable for establishing surgical platform in the process of minimally invasive spine surgery (MISS) is proposed in this paper. According to the requirement of MISS operation, a five-degree-of-freedom (5-DOF) operating mechanism is designed and developed for such applications, and a detailed analysis has been performed for the robot involving the issues of kinematics, control and navigation. In view of the physical constraints imposed by mechanical joints, the operating mechanism is determined. Moreover, the kinematic analysis is carried out via the Denavit-Hartenberg (D-H) representation, and the control system is briefly introduced. Based on the principle of volume reconstruction and Windows programming technology, the surgical navigation system is established. At last, the experimental results made for the prototype illustrate the system well. This research will lay a good foundation for the development of a medical robot to assist in MISS operation.