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2. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

Author

Al-Rim, Ben, Bardtke, Lara, Beheim-Schwarzbach, Jörn Ilmo, Behn, Kerstin, Bergfeld, Leon, Bethke, Norma, Bleicker, Tobias, Briesemeister, Dana, Brumhard, Sophia, Conrad, Claudia, Dieckmann, Sebastian, Frey, Doris, Gabelich, Julie-Anne, Georg, Philipp, Gläser, Ute, Hasler, Lisbeth, Hetey, Andreas, Hiller, Anna Luisa, Horn, Alexandra, Hülso, Claudia, Kegel, Luisa, Koch, Willi, Krannich, Alexander, Kroneberg, Paolo, Lisy, Michelle, Mackeldanz, Petra, Maeß, Birgit, Münn, Friederike, Olk, Nadine, Peiser, Christian, Pohl, Kai, Hermel, Annelie, Rönnefarth, Maria, Rubisch, Carolin, Sanchez Rezza, Angela, Schellenberger, Isabelle, Schenkel, Viktoria, Schlesinger, Jenny, Schmidt, Sein, Schwanitz, Georg, Sinnigen, Anne-Sophie, Stubbemann, Paula, Tesch, Julia, Treue, Denise, Wendisch, Daniel, Zvorc, Saskia, Hillus, David, Schwarz, Tatjana, Tober-Lau, Pinkus, Vanshylla, Kanika, Hastor, Hana, Thibeault, Charlotte, Jentzsch, Stefanie, Helbig, Elisa T, Lippert, Lena J, Tscheak, Patricia, Schmidt, Marie Luisa, Riege, Johanna, Solarek, André, von Kalle, Christof, Dang-Heine, Chantip, Gruell, Henning, Kopankiewicz, Piotr, Suttorp, Norbert, Drosten, Christian, Bias, Harald, Seybold, Joachim, Klein, Florian, Kurth, Florian, Corman, Victor Max, and Sander, Leif Erik

Published
2021
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6. COPD and Inflammation

Author

Peiser, Christian

Subjects
Medical
Abstract

COPD is associated with chronic inflammation of the airways, which causes damage to defense and repair mechanisms, resulting in remodeling processes in the bronchi and bronchioles. This leads to fibrosis of the lung tissue, increased smooth muscle tension, swelling of bronchial mucosa, loss of cilia function with accumulation of mucus, and finally to chronic pulmonary obstruction and possibly emphysema, with the main symptoms of dyspnea, coughing, and expectoration. Inhaled pollutants can activate immune cells like macrophages, T-lymphocytes, and subsequently neutrophilic granulocytes. Together, they release various pro-inflammatory messenger substances and enzymes. As a relevant example, they secrete proteases and disable antiproteases, an imbalance that destabilizes lung tissue. Of particular importance are several cytokines that are significantly elevated in the plasma of patients with COPD signals. In addition to the pathophysiologically clearly defined neutrophilic inflammation, there are also COPD patients with a predominantly eosinophilic inflammation, which could overlap with allergic bronchial asthma. Furthermore, inhaled pollutants can lead to oxidative stress, which increases inflammation and remodeling. Respiratory infections, in most cases bacterial infections, can trigger an exacerbation of already established COPD, in most cases bacterial infections. In addition to conventional medication, in case of refractory therapy, treatment with biologics could be an option.

Published
2022

9. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

Author

Hillus, David, primary, Schwarz, Tatjana, additional, Tober-Lau, Pinkus, additional, Vanshylla, Kanika, additional, Hastor, Hana, additional, Thibeault, Charlotte, additional, Jentzsch, Stefanie, additional, Helbig, Elisa T, additional, Lippert, Lena J, additional, Tscheak, Patricia, additional, Schmidt, Marie Luisa, additional, Riege, Johanna, additional, Solarek, André, additional, von Kalle, Christof, additional, Dang-Heine, Chantip, additional, Gruell, Henning, additional, Kopankiewicz, Piotr, additional, Suttorp, Norbert, additional, Drosten, Christian, additional, Bias, Harald, additional, Seybold, Joachim, additional, Klein, Florian, additional, Kurth, Florian, additional, Corman, Victor Max, additional, Sander, Leif Erik, additional, Al-Rim, Ben, additional, Bardtke, Lara, additional, Beheim-Schwarzbach, Jörn Ilmo, additional, Behn, Kerstin, additional, Bergfeld, Leon, additional, Bethke, Norma, additional, Bleicker, Tobias, additional, Briesemeister, Dana, additional, Brumhard, Sophia, additional, Conrad, Claudia, additional, Dieckmann, Sebastian, additional, Frey, Doris, additional, Gabelich, Julie-Anne, additional, Georg, Philipp, additional, Gläser, Ute, additional, Hasler, Lisbeth, additional, Hetey, Andreas, additional, Hiller, Anna Luisa, additional, Horn, Alexandra, additional, Hülso, Claudia, additional, Kegel, Luisa, additional, Koch, Willi, additional, Krannich, Alexander, additional, Kroneberg, Paolo, additional, Lisy, Michelle, additional, Mackeldanz, Petra, additional, Maeß, Birgit, additional, Münn, Friederike, additional, Olk, Nadine, additional, Peiser, Christian, additional, Pohl, Kai, additional, Hermel, Annelie, additional, Rönnefarth, Maria, additional, Rubisch, Carolin, additional, Sanchez Rezza, Angela, additional, Schellenberger, Isabelle, additional, Schenkel, Viktoria, additional, Schlesinger, Jenny, additional, Schmidt, Sein, additional, Schwanitz, Georg, additional, Sinnigen, Anne-Sophie, additional, Stubbemann, Paula, additional, Tesch, Julia, additional, Treue, Denise, additional, Wendisch, Daniel, additional, and Zvorc, Saskia, additional

Published
2021
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10. Dopamine type 2 receptor expression and function in rodent sensory neurons projecting to the airways

Author

Peiser, Christian, Trevisani, Marcello, Groneberg, David A., Dinh, Q. Thai, Lencer, Doerthe, Amadesi, Silvia, Maggiore, Barbara, Harrison, Selena, Geppetti, Pierangelo, and Fischer, Axel

Subjects
Rats -- Physiological aspects, Rats -- Research, Rattus -- Physiological aspects, Rattus -- Research, Neurons, Ganglion, Dopamine receptors, Biological sciences
Abstract

Agonists of the dopamine receptors have been demonstrated to have bronchodilatory properties in pathologically constricted airways. The mechanism by which these agonists induce bronchodilatation is thought to involve airway sensory nerves. In this study, the expression and function of dopamine [D.sub.2] receptor were examined in sensory ganglia supplying the airways. Neuronal dopamine [D.sub.2] receptor mRNA expression was demonstrated by single-cell RT-PCR following laser-assisted microdissection. The projection of the neurons to the airways was confirmed by retrograde neuronal labeling. In functional studies, dopamine [D.sub.2] receptor agonists (AR-C65116AB and ropinirole) inhibited intraneuronal calcium mobilization in rat capsaicin-sensitive primary sensory neurons and capsaicin-induced plasma extravasation in the rat trachea. Our results provide support to the hypothesis that dopamine [D.sub.2] receptor activation inhibits neurogenic inflammation and proinflammatory reflex responses. [D.sub.2] dopamine receptor; jugular-nodose ganglion; dorsal root ganglion; rat

Published
2005

21. Distribution of salivary aquaporin-5 in Sjogren's syndrome

Author

Fischer, Axel, Peiser, Christian, Groneberg, David A, Jonsson, Roland, Gordon, Tom P, Hiscock, Jenny, Beroukas, Dimitra, Waterman, Sally A, Delporte, Christine, and Steinfeld, Serge D

Subjects
Sjogren's syndrome -- Physiological aspects, Salivary glands -- Physiological aspects, Lacrimal organs -- Physiological aspects
Published
2002

22. Bronchitis in Children

Author

Peiser, Christian

Subjects
Medical / Pulmonary & Thoracic Medicine
Abstract

Bronchitis in Children

Published
2012

24. Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease

Author

Springer, Jochen, Scholz, Frank R., Peiser, Christian, Dinh, Q. Thai, Fischer, Axel, Quarcoo, David, Groneberg, Jan David Alexander, Springer, Jochen, Scholz, Frank R., Peiser, Christian, Dinh, Q. Thai, Fischer, Axel, Quarcoo, David, and Groneberg, Jan David Alexander

Abstract

Background: Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD). Suppressor of cytokine signaling (SOCS) family members are involved in the pathogenesis of many inflammatory diseases and SOCS-3 has been shown to play an important role in the regulation, onset and maintenance of airway allergic inflammation indicating that SOCS-3 displays a potential therapeutic target for anti-inflammatory respiratory drugs development. Since chronic obstructive pulmonary disease (COPD) is also characterized by inflammatory changes and airflow limitation, the present study assessed the transcriptional expression of SOCS-3 in COPD. Methods: Real-time PCR was performed to assess quantitative changes in bronchial biopsies of COPD patients in comparison to unaffected controls. Results: SOCS-3 was significantly down-regulated in COPD at the transcriptional level while SOCS-4 and SOCS-5 displayed no change. Conclusions: It can be concluded that the presently observed inhibition of SOCS-3 mRNA expression may be related to the dysbalance of cytokine signaling observed in COPD.

Published
2013

25. Leptinrezeptor: Signaltransduktor und Vehikel

Author

Peiser, Christian and Prof. Dr. Rudolf E. Lang

Subjects
Medizin, Gesundheit -- Medical sciences, Medicine, Medical sciences, Medicine, ddc:610, Medizin, Gesundheit, 2000
Published
2002

27. Towards a Personalised Approach to Managing Influenza Infections in Infants and Children – Food for Thought and a Note on Oseltamivir

Author

Rath, Barbara, primary, Tief, Franziska, additional, Karsch, Katharina, additional, Muehlhans, Susann, additional, Obermeier, Patrick, additional, Adamou, Eleni, additional, Chen, Xi, additional, Seeber, Lea, additional, Peiser, Christian, additional, Hoppe, Christian, additional, Kleist, Max, additional, Conrad, Tim, additional, and Schweiger, Brunhilde, additional

Published
2013
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28. Specific immunotherapy in Albanian patients with anaphylaxis to hymenoptera venoms

Author

Mingomataj, Ervin, Priftanji, Alfred, Qirko, Etleva, Dinh, Q. Thai, Fischer, Axel, Peiser, Christian, Groneberg, Jan David Alexander, Mingomataj, Ervin, Priftanji, Alfred, Qirko, Etleva, Dinh, Q. Thai, Fischer, Axel, Peiser, Christian, and Groneberg, Jan David Alexander

Abstract

Background: Severe allergic reactions during rush-specific immunotherapy (Rush-SIT) may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allergic reactions during Rush-SIT in a cohort of patients with allergy towards hymenoptera venom in the mediterranean population of Albania. Methods: A retrospective study was performed using the clinical reports of 37 patients with venom of bee (apinae), wasp (vespidae, subfamily vespinae) or paperwasp (vespidae, subfamily polistinae) allergy treated with Rush-SIT between 1987 and 1996. After hymenoptera sting allergy diagnosis according to anamnesis and intracutaneous tests the patient were treated with Rush-SIT. The protocol lasted 3 - 4 d with an increase in the concentration from 0.01 microg/ml to 100 microg/ml. Anaphylactic reactions were classified according to the Mueller-classification. Results: The frequency of reactions during Rush-SIT for bee-venom was 4.7% and for wasp-venom was 1.5% (p < 0.01). The mean frequency of reactions of Mueller grade II for the bee-venom Rush-SIT patients during the first 4 d (= 26 injections) was 0.73 and for the wasp-venom Rush-SIT patients 0.15. No patient experienced a third-degree reaction. 94.6% of the patient supported an end dose of 100 microg. Conclusions: Rush-SIT is a reliable method for the treatment of anaphylactic reactions to hymenoptera venom even in less developed countries. Bee-venom Rush-SIT was found to cause higher numbers allergic reactions than wasp or paperwasp Rush-SIT.

Published
2002

35. Distribution of Respiratory Mucin Proteins in Human Nasal Mucosa

Author

Groneberg, David A., primary, Peiser, Christian, additional, Dinh, Q. Thai, additional, Matthias, John, additional, Eynott, Paul R., additional, Heppt, Werner, additional, Carlstedt, Ingemar, additional, Witt, Christian, additional, Fischer, Axel, additional, and Chung, K. Fan, additional

Published
2003
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42. Leptin: A Potent Inhibitor of Insulin Secretion

Author

Fehmann, Hans-Christoph, primary, Peiser, Christian, additional, Bode, Hans-Peter, additional, Stamm, Matthias, additional, Staats, Petra, additional, Hedetoft, Christoffer, additional, Lang, Rudolf Ernst, additional, and Göke, Burkhard, additional

Published
1997
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44. Dopamine D2 receptor mRNA expression is increased in the jugular-nodose ganglia of rats with nitrogen dioxide-induced chronic bronchitis

Author

Peiser, Christian, Andreae, Doerthe A., Groneberg, David A., Dinh, Q. Thai, Müller, Bernd, Wahn, Ulrich, and Fischer, Axel

Subjects
*DOPAMINE receptors, *MESSENGER RNA, *GENE expression, *SENSORY ganglia, *NITROGEN dioxide, *BRONCHITIS, *LABORATORY rats
Abstract

Abstract: The bronchodilatatory effect of inhaled dopamine or dopamine D2 receptor agonists in cases of bronchial constriction may involve the suppression of pathologically increased airway sensory nerve activity. The aim of this study is to investigate the regulation of the dopamine D2 receptor mRNA expression in the ganglia of rats with nitrogen dioxide-induced chronic bronchitis compared with that in ganglia of healthy control animals. Rats were exposed to nitrogen dioxide (10ppm, 20d) and dopamine D2 receptor mRNA levels in sensory ganglia (jugular-nodose, trigeminal, cervical dorsal root and thoracic dorsal root ganglia) were examined by quantitative real-time polymerase chain reaction and compared to control tissues. Whereas for trigeminal and dorsal root ganglia the dopamine D2 receptor expression levels showed no difference between both animal groups, there was a significant (p <0.05) increase in the jugular-nodose ganglia with a 2.1-fold factor. The increase of dopamine D2 receptor mRNA in jugular-nodose sensory neurons which innervate the airways may represent a neurochemical basis for the effects seen in man and animal models following topical administration of dopamine or dopamine agonists onto the respiratory epithelium. [Copyright &y& Elsevier]

Published
2009
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45. Abundant Expression of Vasoactive Intestinal Polypeptide Receptor VPAC2 mRNA in Human Skin.

Author

Fischer, Tanja C., Hartmann, Petra, Löser, Christoph, Springer, Jochen, Peiser, Christian, Dinh, Q. Thai, Fischer, Axel, and Groneberg, David A.

Subjects
*VASOACTIVE intestinal peptide, *NEUROTRANSMITTERS, *SENSORY neurons, *SKIN
Abstract

Presents a study carried out to correlate the bioactive peptide vasoactive intestinal polypeptide (VIP) and its receptor in the human skin. Influence of VIP over many aspects of cell function and differentiation; Presence in cutaneous autonomic and sensory nerve fibers where it acts as neuromodulator and participates in the regulation of regional blood flow.

Published
2001
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46. [Emergency department management of mild traumatic brain injury in children - an evidencebased algorithmic approach].

Author

Leidel BA, Peiser C, Wolf S, and Kanz KG

Subjects
Adolescent, Brain pathology, Child, Child Abuse diagnosis, Child Abuse legislation & jurisprudence, Child, Preschool, Craniocerebral Trauma etiology, Female, Glasgow Coma Scale, Humans, Infant, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed, Algorithms, Cerebral Hemorrhage, Traumatic diagnosis, Cerebral Hemorrhage, Traumatic etiology, Craniocerebral Trauma diagnosis, Emergency Service, Hospital, Evidence-Based Medicine
Published
2016
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47. Towards a personalised approach to managing influenza infections in infants and children - food for thought and a note on oseltamivir.

Author

Rath B, Tief F, Karsch K, Muehlhans S, Obermeier P, Adamou E, Chen X, Seeber L, Peiser C, Hoppe C, von Kleist M, Conrad T, and Schweiger B

Subjects
Antiviral Agents pharmacology, Child, Child, Preschool, Coinfection diagnosis, Coinfection drug therapy, Coinfection prevention & control, Coinfection virology, Drug Resistance, Viral, Early Diagnosis, Enzyme Inhibitors therapeutic use, Humans, Infant, Infant, Newborn, Influenza A virus enzymology, Influenza A virus growth & development, Influenza A virus isolation & purification, Influenza, Human complications, Influenza, Human diagnosis, Influenza, Human virology, Neuraminidase antagonists & inhibitors, Oseltamivir pharmacology, Oseltamivir therapeutic use, Patient Isolation, Respiratory Tract Infections diagnosis, Respiratory Tract Infections drug therapy, Respiratory Tract Infections prevention & control, Respiratory Tract Infections virology, Viral Proteins antagonists & inhibitors, Antiviral Agents therapeutic use, Evidence-Based Medicine, Influenza A virus drug effects, Influenza, Human drug therapy, Precision Medicine
Abstract

Acute respiratory infections represent common diseases in childhood and a challenge to infection control, public heath, and the clinical management of patients and their families. Children are avid spreaders of respiratory viruses, and seasonal outbreaks of influenza create additional disease burden and healthcare cost. Infants under the age of two and children with chronic conditions are at high risk. The absence of pre-defined risk factors however, does not protect from serious disease. Immunisation rates remain low, and physical interventions are of limited value in young children. Children with influenza may be contagious prior to the onset of symptoms, and school closures have been shown to have a temporary effect at most. The timely detection of influenza in at-risk patients is important to prevent hospital-based transmission and influenza-associated morbidity and mortality. Guidelines issued by professional associations and public health agencies need to be translated into everyday clinical practice. Antiviral therapy should be initiated early and monitored closely, including virologic and clinical outcomes. The duration of treatment and the decision to readmit children to schools and kindergartens should be adjusted to the individual child patient using evidence-based clinical and virologic criteria. This article presents lessons learnt from a quality management program for infants and children with influenza-like illness at the Charite Department of Paediatrics in collaboration with the National Reference Centre for Influenza at the Robert Koch Institute, in Berlin, Germany. The Charité Influenza-Like Disease (ChILD) Cohort was established during the 2009 influenza pandemic and encompasses nearly 4000 disease episodes to date.

Published
2013
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48. Expression of substance P and nitric oxide synthase in vagal sensory neurons innervating the mouse airways.

Author

Dinh QT, Groneberg DA, Peiser C, Joachim RA, Frossard N, Arck PC, Klapp BF, and Fischer A

Subjects
Amidines, Animals, Female, Gene Expression, Immunohistochemistry, Mice, Nitric Oxide Synthase Type I, Jugular Veins innervation, Nerve Tissue Proteins biosynthesis, Neurons, Afferent metabolism, Nitric Oxide Synthase biosynthesis, Nodose Ganglion physiology, Substance P biosynthesis
Abstract

Introduction: Airway sensory nerves have the capacity to release neuromediators such as substance P and nitric oxide to control airway functions. The aim of the present study was to investigate substance P and neuronal nitric oxide synthase (NOS-1) expression in airway-specific sensory neurons., Methods: Airway-projecting neurons in the jugular-nodose ganglia were investigated for NOS-1 and substance P expression by neuronal tracing and double-labelling immunoreactivity., Results: Of the Fast blue labelled neurons, 14.6+/-1.8% (mean+/-S.E.M.) were immunoreactive only for NOS-1, 3.0+/-0.3% for NOS-1 and substance P, 2.7+/-0.3% only for substance P, and 79.7+/-1.7% of the labelled neurons were nonimmunoreactive for substance P or NOS-1 but were partly positive for I-B4-lectin-binding. Fast blue labelled NOS and/or substance P-positive neurons were small to medium sized (<20 microm)., Conclusion: Based on the expression of substance P and nitric oxide synthase in airway neurons, the present study suggests that there may be substance P and NO biosynthesis and release following a peripheral activation of the afferents, there could be a triggering of substance P and NO-mediated phenomena, including those related to airway inflammation, such as plasma extravasation and vasodilatation.

Published
2005
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