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374 results on '"Pekkonen, Eero"'

9. GPi-DBS-induced brain metabolic activation in cervical dystonia

Author

Honkanen, Emma A, primary, Rönkä, Jaana, additional, Pekkonen, Eero, additional, Aaltonen, Juho, additional, Koivu, Maija, additional, Eskola, Olli, additional, Eldebakey, Hazem, additional, Volkmann, Jens, additional, Kaasinen, Valtteri, additional, Reich, Martin M, additional, and Joutsa, Juho, additional

Published
2023
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13. Levodopa‐Entacapone‐Carbidopa Intestinal Gel Treatment in Advanced Parkinson's Disease: A Single‐Center Study of 30 Patients.

Author

Viljaharju, Vili, Mertsalmi, Tuomas, Pauls, K. Amande M., Koivu, Maija, Eerola‐Rautio, Johanna, Udd, Marianne, and Pekkonen, Eero

Subjects
PARKINSON'S disease, INTESTINES, TERMINATION of treatment
Abstract

Background: Levodopa‐entacapone‐carbidopa intestinal gel (LECIG) is a novel device assisted treatment option for advanced Parkinson's disease (PD). It has been available in Finland since 2020. There is paucity of scientific studies considering LECIG treatment in clinical practice. Objectives: Objectives of this study were to evaluate the changes in medication, adverse events and early discontinuations of LECIG treatment in real life clinical practice. Methods: The records of 30 consecutive patients, who received LECIG between years 2020 and 2022 in Helsinki University Hospital, were retrospectively analyzed. Data considering changes in medication, discontinuations, and adverse events during the first six months of LECIG treatment was collected. Results: Mean levodopa equivalent daily dose (LEDD) rose significantly between baseline before LECIG and six months with treatment (1230 mg vs. 1570 mg, P = 0.001). Three patients were discarded during nasojejunal tube test phase and seven discontinued the treatment during six‐month follow‐up. Most common reasons for discontinuation were difficulty in finding suitable infusion rate and neuropsychiatric problems. Safety issues encountered were similar to those reported with levodopa‐carbidopa intestinal gel (LCIG) treatment. One case of rhabdomyolysis due to severe dyskinesia during LECIG treatment was observed. Patients were satisfied with the small size of the pump system. Conclusions: LEDD seems to increase during the first months of LECIG treatment. When compared to studies on LCIG, safety profile of LECIG appears similar, but early discontinuation rate is higher than expected. However, long‐term studies are lacking. Only clear advantage to LCIG appears to be the smaller LECIG pump size. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Dopamine transporter binding in the brain is linked to irritable bowel syndrome in Parkinson's disease

Author

Murtomäki, Kirsi, primary, Joutsa, Juho, additional, Mertsalmi, Tuomas, additional, Jaakkola, Elina, additional, Mäkinen, Elina, additional, Levo, Reeta, additional, Eklund, Mikael, additional, Nuuttila, Simo, additional, Pekkonen, Eero, additional, Noponen, Tommi, additional, Ihalainen, Toni, additional, Kaasinen, Valtteri, additional, and Scheperjans, Filip, additional

Published
2023
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15. Feasibility and patient acceptability of a commercially available wearable and a smart phone application in identification of motor states in parkinson’s disease

Author

Liikkanen, Sammeli, primary, Sinkkonen, Janne, additional, Suorsa, Joni, additional, Kaasinen, Valtteri, additional, Pekkonen, Eero, additional, Kärppä, Mikko, additional, Scheperjans, Filip, additional, Huttunen, Teppo, additional, Sarapohja, Toni, additional, Pesonen, Ullamari, additional, Kuoppamäki, Mikko, additional, and Keränen, Tapani, additional

Published
2023
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26. Gastrointestinal Symptoms and Dopamine Transporter Asymmetry in Early Parkinson's Disease

Author

Murtomäki, Kirsi, primary, Mertsalmi, Tuomas, additional, Jaakkola, Elina, additional, Mäkinen, Elina, additional, Levo, Reeta, additional, Nojonen, Tanja, additional, Eklund, Mikael, additional, Nuuttila, Simo, additional, Lindholm, Kari, additional, Pekkonen, Eero, additional, Joutsa, Juho, additional, Noponen, Tommi, additional, Ihalainen, Toni, additional, Kaasinen, Valtteri, additional, and Scheperjans, Filip, additional

Published
2022
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27. Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease

Author

Valkonen, Kati, Mäkelä, Jyrki P., Airaksinen, Katja, Nurminen, Jussi, Kivisaari, Riku, Renvall, Hanna, Pekkonen, Eero, Neurologian yksikkö, HUS Neurocenter, Department of Neurosciences, HUS Medical Imaging Center, BioMag Laboratory, Neurokirurgian yksikkö, University of Helsinki, Clinicum, Helsinki University Hospital, Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, and Aalto University

Subjects
MAGNETOENCEPHALOGRAPHY, IMPROVEMENT, MUSCULAR COHERENCE, SIGNAL-SPACE SEPARATION, MAGNETIC-FIELDS, 3124 Neurology and psychiatry, nervous system diseases, MECHANISMS, ACTIVATION, surgical procedures, operative, nervous system, SYNCHRONIZATION, CONNECTIONS, therapeutics, RESPONSES
Abstract

Publisher Copyright: Copyright: © 2022 Valkonen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson’s disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS.

Published
2022

28. Essentiaalisen vapinan oireet, diagnostiikka ja hoito

Author

Ortiz, Rebekka, Honkaniemi, Jari, Pekkonen, Eero, Tampere University, Kliininen lääketiede, Neuroalojen ja kuntoutuksen vastuualue, HUS Neurokeskus, Neurologian yksikkö, and Neurotieteiden osasto

Subjects
+drug therapy, +therapy, Essential Tremor, +diagnosis, Deep Brain Stimulation, +psychology, Neurocognitive Disorders, +surgery, 3112 Neurotieteet, 3124 Neurologia ja psykiatria
Abstract

Vertaisarvioitu. • Keskeinen oire essentiaalisessa vapinassa on yläraajojen molemminpuolinen aktiovapina. Myös muiden alueiden vapinaa voi esiintyä. • Oirekuvaan saattaa liittyä lieväasteisina myös muita neurologisia oireita, kuten lepovapinaa, kognitiivisia ongelmia, ataksiaa ja tasapainon vaikeuksia. • Muut kuin motoriset oireet, kuten mieliala- ja muistioireet, ovat myös tavallisia, ja ne vaikuttavat merkittävästi elämänlaatuun. • Lääkehoidosta hyötyy noin puolet potilaista. Vaikeassa sairaudessa on harkittava syväaivostimulaatiota.

Published
2022

30. Gut microbiome alterations in fecal samples of treatment-naïve de novo Parkinson’s disease patients

Author

Boertien, Jeffrey M, primary, Murtomäki, Kirsi, additional, Pereira, Pedro AB, additional, van der Zee, Sygrid, additional, Mertsalmi, Tuomas H, additional, Levo, Reeta, additional, Nojonen, Tanja, additional, Mäkinen, Elina, additional, Jaakkola, Elina, additional, Laine, Pia, additional, Paulin, Lars, additional, Pekkonen, Eero, additional, Kaasinen, Valtteri, additional, Auvinen, Petri, additional, Scheperjans, Filip, additional, and van Laar, Teus, additional

Published
2022
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36. Personalised Advanced Therapies in Parkinson’s Disease: The Role of Non-Motor Symptoms Profile

Author

Leta, Valentina, primary, Dafsari, Haidar S., additional, Sauerbier, Anna, additional, Metta, Vinod, additional, Titova, Nataliya, additional, Timmermann, Lars, additional, Ashkan, Keyoumars, additional, Samuel, Michael, additional, Pekkonen, Eero, additional, Odin, Per, additional, Antonini, Angelo, additional, Martinez-Martin, Pablo, additional, Parry, Miriam, additional, van Wamelen, Daniel J., additional, and Ray Chaudhuri, K., additional

Published
2021
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37. Validation of the Finnish Version of the Unified Dyskinesia Rating Scale

Author

Kaasinen, Valtteri, primary, Scheperjans, Filip, additional, Kärppä, Mikko, additional, Korpela, Jaana, additional, Brück, Anna, additional, Sipilä, Jussi O.T., additional, Joutsa, Juho, additional, Järvelä, Juha, additional, Eerola-Rautio, Johanna, additional, Martikainen, Mika H., additional, Airaksinen, Katja, additional, Stebbins, Glenn T., additional, Martinez-Martin, Pablo, additional, Goetz, Christopher G., additional, Lin, Jeffrey, additional, Luo, Sheng, additional, and Pekkonen, Eero, additional

Published
2021
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39. Personalised Advanced Therapies in Parkinson's Disease: The Role of Non-Motor Symptoms Profile

Author

Leta, Valentina, Dafsari, Haidar S., Sauerbier, Anna, Metta, Vinod, Titova, Nataliya, Timmermann, Lars, Ashkan, Keyoumars, Samuel, Michael, Pekkonen, Eero, Odin, Per, Antonini, Angelo, Martinez-Martin, Pablo, Parry, Miriam, van Wamelen, Daniel J., Ray Chaudhuri, K., Leta, Valentina, Dafsari, Haidar S., Sauerbier, Anna, Metta, Vinod, Titova, Nataliya, Timmermann, Lars, Ashkan, Keyoumars, Samuel, Michael, Pekkonen, Eero, Odin, Per, Antonini, Angelo, Martinez-Martin, Pablo, Parry, Miriam, van Wamelen, Daniel J., and Ray Chaudhuri, K.

Abstract

Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, are available in many countries for the management of the advanced stage of Parkinson's disease (PD). Currently, selection of device-aided therapies is mainly focused on patients' motor profile while non-motor symptoms play a role limited to being regarded as possible exclusion criteria in the decision-making process for the delivery and sustenance of a successful treatment. Differential beneficial effects on specific non-motor symptoms of the currently available device-aided therapies for PD are emerging and these could hold relevant clinical implications. In this viewpoint, we suggest that specific non-motor symptoms could be used as an additional anchor to motor symptoms and not merely as exclusion criteria to deliver bespoke and patient-specific personalised therapy for advanced PD.

Published
2021

42. Dystoniat ja syväaivostimulaatio aikuisilla

Author

Ortiz, Rebekka, Scheperjans, Filip, Mertsalmi, Tuomas, Pekkonen, Eero, HUS Neurokeskus, Neurologian yksikkö, Helsingin yliopisto, Clinicum, Neurotieteiden osasto, HUS Kuvantaminen, and BioMag-laboratorio

Subjects
Adult, Dystonia, +therapy, Deep Brain Stimulation, 3112 Neurotieteet, 3124 Neurologia ja psykiatria
Published
2020

49. Single‐Center Study of 103 Consecutive Parkinson's Disease Patients with Levodopa‐Carbidopa Intestinal Gel.

Author

Viljaharju, Vili, Mertsalmi, Tuomas, Pauls, K. Amande M., Koivu, Maija, Eerola‐Rautio, Johanna, Udd, Marianne, and Pekkonen, Eero

Subjects
PARKINSON'S disease, LIVING alone, TERTIARY care, INTESTINES
Abstract

Background: Levodopa‐carbidopa intestinal gel (LCIG) effectively reduces off time and dyskinesia and increases on time in advanced Parkinson's disease (PD). However, patients with LCIG‐infusion experience frequent complications and some discontinue treatment early on. Objectives: The objectives of this study were to find predictive factors for early dropout from the LCIG infusion, analyze the treatment burden on the tertiary health care system, and explore changes in medication during the LCIG treatment. Methods: LCIG‐infusion was administrated to 103 patients between July 2006 and May 2020 at the Helsinki University Hospital, accumulating 350 years of follow‐up data. We evaluated, retrospectively, changes in medication during treatment, discontinuation of the infusion, and adverse events from the patient records. Results: Living alone was a predictive factor for early dropout (OR = 3.88; 95% CI = 1.03–14.66; P = 0.045). The treatment burden on the tertiary health care system increased after the initiation of LCIG infusion mostly because of common complications related to the infusion system (median change of in‐ and out‐patient visits +1, P = 0.03). Mean levodopa equivalent daily dose (LEDD) rose from baseline to 6 months (1246.7 vs. 1684.9, P = 0.001) and stabilized thereafter. Patients commonly switched from "polypharmacy" to "LCIG‐only" or "LCIG + oral levodopa" medication‐groups during long‐term treatment. Conclusions: Recurrent complications related to the infusion system increase the treatment burden on tertiary healthcare system after the initiation of LCIG‐infusion. Most patients continue long‐term with the infusion. Few patients discontinue infusion during the first year after initiation and living alone appears to be a risk factor for this outcome. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Additional file 1: of Deep brain stimulation for dystonia in Finland during 2007–2016

Author

Ortiz, Rebekka, Scheperjans, Filip, and Pekkonen, Eero

Abstract

Table S1. The clinical response as measured with GDS in different patient groups in isolated dystonia. The clinical response as measured with GDS at 6 and 12 months with isolated dystonia patients did not differ between age groups under vs. over 50 years, duration of disease under vs. over 10 years, patients with vs. without previously diagnosed depression or that had been operated with and without MER. (DOCX 13 kb)

Published
2019
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