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8. Seizures, focal neurological signs, and pneumococcal aetiology associate with impaired consciousness in childhood bacterial meningitis.

Author

Valtiala, Ester, Roine, Irmeli, Cruzeiro, Manuel Leite, Peltola, Heikki, and Pelkonen, Tuula

Subjects
BACTERIAL meningitis, ETIOLOGY of diseases, GLASGOW Coma Scale, SEIZURES (Medicine), PNEUMOCOCCAL vaccines, TREATMENT delay (Medicine)
Abstract

Aim: A low Glasgow Coma Scale Score (GCS) on admission is a known predictor of poor outcome from childhood bacterial meningitis. In turn, the factors associated with the admission GCS are less known. Our aim was to identify them, both for clinical alerts of reserved prognosis and to find potential targets for intervention. Methods: This study is a secondary analysis of data collected prospectively in Angola and in Latin America between 1996 and 2007. Children with bacterial meningitis were examined on hospital admission and their GCS was assessed using the age‐adjusted scale. Associations between on‐admission GCS and host clinical factors were examined. Results: A total of 1376 patients with confirmed bacterial meningitis were included in the analysis (609 from Latin America and 767 from Angola). The median GCS was 13 for all patients (12 in Angola and 13 in Latin America). In the multivariate analysis, in the areas combined, seizures, focal neurological signs, and pneumococcal aetiology associated with GCS <13, as did treatment delay in Latin America. Conclusion: Besides pneumococcal aetiology, we identified characteristics, easily registrable on admission, which are associated with a low GCS in childhood bacterial meningitis. Of these, expanding pneumococcal vaccinations and treatment delays could be modified. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Pneumonia in childhood bacterial meningitis–Experience from three continents.

Author

Pelkonen, Tuula, Roine, Irmeli, Cruzeiro, Manuel Leite, Kallio, Markku, and Peltola, Heikki

Subjects
BACTERIAL meningitis, PNEUMONIA, DISEASE complications, CHEST X rays, CONTINENTS, MULTIVARIATE analysis
Abstract

Introduction: Although concomitant pneumonia is sometimes diagnosed in childhood bacterial meningitis, its role in the illness course and prognosis is not known. We examined these associations using prospectively collected data from Finland, Latin America and Angola. Methods: This was a secondary descriptive analysis of prospectively collected data (clinical and laboratory findings at admission, during hospitalisation and outcome) from five clinical bacterial meningitis trials. We included children aged 2 months to 15 years from sites with confirmed bacterial meningitis and potential concomitant pneumonia (diagnosed clinically with or without a chest radiograph). Results: Pneumonia was not observed in the 341 children included in Finland. Pneumonia was observed in 8% (51/606) of children in Latin America and in 46% (377/819) in Angola (p < 0.0001). In multivariate analyses, predisposing factors for pneumonia in Latin America were age <1 year, seizures and severe anaemia; the corresponding factors for Angola were preadmission duration of illness >3 days and non‐meningococcal meningitis. Concomitant pneumonia increased the severity of the disease and disabling sequelae. Conclusion: Bacterial meningitis with pneumonia is a major, previously undescribed entity of severe bacterial meningitis, especially in Angola. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Reply to Bradley

Author

Peltola, Heikki, Pääkkönen, Markus, Kallio, Pentti, and Kallio, Markku J. T.

Published
2009

31. Vaccine-induced waning of Haemophilus influenzae empyema and meningitis, Angola

Author

Peltola, Heikki, Pelkonen, Tuula, Bernardino, Luis, Monteiro, Lurdes, Silvestre, Silvia da Conceicao, Anjos, Elizabete, Cruzeiro, Manuel Leite, Pitkaranta, Anne, and Roine, Irmeli

Subjects
Diagnosis, Diseases, Vaccines, Empyema -- Diagnosis, Meningitis -- Diagnosis, Pneumonia -- Diagnosis, Vaccination, Hemophilus infections -- Diagnosis, Bacterial pneumonia -- Diagnosis
Abstract

In sub-Saharan Africa, most children with severe community-acquired pneumonia are discharged from care with the causative agent unidentified. In the few diagnosed cases, diagnosis is usually based on positive blood [...]

Published
2014
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48. Laumaimmuniteetista tai rokotteestako ratkaisu COVID-19-tautiin?

Author

Peltola, Heikki, HUS Lasten ja nuorten sairaudet, Lastentautien yksikkö, and Lastenklinikka

Subjects
Immunity, Herd, Vaccines, 3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet, 3111 Biolääketieteet, 317 Farmasia, +prevention & control, 11832 Mikrobiologia ja virologia, Coronavirus Infections, Pandemics
Published
2020

50. Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial

Author

Peltola, Heikki, Roine, Irmeli, Fernandez, Josefina, Zavala, Ines, Ayala, Silvia Gonzalez, Mata, Antonio Gonzalez, Arbo, Antonio, Bologna, Rosa, Mino, Greta, Goyo, Jose, Lopez, Eduardo, de Andrade, Solange Dourado, and Sarna, Seppo

Subjects
Bacterial meningitis -- Demographic aspects, Bacterial meningitis -- Drug therapy, Glycerin -- Dosage and administration, Glycerin -- Physiological aspects, Glycerol -- Dosage and administration, Glycerol -- Physiological aspects, Dexamethasone -- Dosage and administration, Dexamethasone -- Physiological aspects, Placebos -- Usage, Hemophilus influenzae -- Health aspects, Experimental design, Health, Health care industry
Published
2007

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