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21 results on '"Pelzel-McCluskey, Angela M."'

3. Surveillance of Feral Swine (Sus scrofa ) in the Western USA for Antibodies to Vesicular Stomatitis Virus, 2013–21.

Author

Haynes, Ellen, Cleveland, Christopher A., Brown, Vienna R., Pelzel-McCluskey, Angela M., Tell, Rachel M., and Stallknecht, David E.

Abstract

Vesicular stomatitis virus (VSV) outbreaks periodically occur in livestock in the western US and are thought to originate from outside this country. Feral swine (Sus scrofa) have been identified as an amplifying host for vesicular stomatitis New Jersey virus (VSNJV) and have been used to better understand the epidemiology of this virus through serosurveillance. This study aimed to determine if antibodies to vesicular stomatitis Indiana virus (VSIV) and VSNJV were present in feral swine in the western US and to determine if seropositive animals were associated with areas of previously detected VSV in livestock. A total of 4,541 feral swine samples was tested using virus neutralization (VN); samples exhibiting neutralizing activity against one or more of the viruses were confirmed using competitive ELISA (cELISA). Eight sera exhibited neutralizing activity by VN assay and a single serum sample from an animal from Kinney County, Texas sampled in December 2019 tested positive for antibodies to VSIV by cELISA. This finding is supported by a local outbreak of VSIV in horses in the same county in June 2019. The low prevalence of antibodies against VSNJV and VSIV was unexpected but indicates that feral swine in the western US do not represent an endemic reservoir for either of these viruses. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Vesicular Stomatitis Virus Detected in Biting Midges and Black Flies during the 2023 Outbreak in Southern California.

Author

Scroggs, Stacey L. P., Swanson, Dustin A., Steele, Taylor D., Hudson, Amy R., Reister-Hendricks, Lindsey M., Gutierrez, Jessica, Shults, Phillip, McGregor, Bethany L., Taylor, Caitlin E., Davis, Travis M., Lamberski, Nadine, Phair, Kristen A., Howard, Lauren L., McConnell, Nathan E., Gurfield, Nikos, Drolet, Barbara S., Pelzel-McCluskey, Angela M., and Cohnstaedt, Lee W.

Subjects
BLOODSUCKING insects, VESICULAR stomatitis, SIMULIIDAE, VIRUS diseases, WATCHFUL waiting
Abstract

Vesicular stomatitis (VS) is a viral disease that affects horses, cattle, and swine that is transmitted by direct contact and hematophagous insects. In 2023, a multi-state outbreak of vesicular stomatitis New Jersey virus (VSNJV) occurred in California, Nevada, and Texas, infecting horses, cattle, and rhinoceros. To identify possible insect vectors, we conducted insect surveillance at various locations in San Diego County, CA, including at a wildlife park. CO2 baited traps set from mid-May to mid-August 2023 collected 2357 Culicoides biting midges and 1215 Simulium black flies, which are insect genera implicated in VSNJV transmission. Insects were pooled by species, location, and date, then tested for viral RNA. Nine RNA-positive pools of Culicoides spp. and sixteen RNA-positive pools of Simulium spp were detected. Infectious virus was detected by cytopathic effect in 96% of the RNA-positive pools. This is the first report of VSNJV in wild-caught C. bergi, C. freeborni, C. occidentalis, S. argus, S. hippovorum, and S. tescorum. The vector competency of these species for VSNJV has yet to be determined but warrants examination. Active vector surveillance and testing during disease outbreaks increases our understanding of the ecology and epidemiology of VS and informs vector control efforts. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Modeling the 2014–2015 Vesicular Stomatitis Outbreak in the United States Using an SEIR-SEI Approach.

Author

Humphreys, John M., Pelzel-McCluskey, Angela M., Shults, Phillip T., Velazquez-Salinas, Lauro, Bertram, Miranda R., McGregor, Bethany L., Cohnstaedt, Lee W., Swanson, Dustin A., Scroggs, Stacey L. P., Fautt, Chad, Mooney, Amber, Peters, Debra P. C., and Rodriguez, Luis L.

Subjects
*VESICULAR stomatitis, *MARKOV chain Monte Carlo, *VECTOR-borne diseases, *INFECTIOUS disease transmission, *INSECT hosts
Abstract

Vesicular stomatitis (VS) is a vector-borne livestock disease caused by the vesicular stomatitis New Jersey virus (VSNJV). This study presents the first application of an SEIR-SEI compartmental model to analyze VSNJV transmission dynamics. Focusing on the 2014–2015 outbreak in the United States, the model integrates vertebrate hosts and insect vector demographics while accounting for heterogeneous competency within the populations and observation bias in documented disease cases. Key epidemiological parameters were estimated using Bayesian inference and Markov chain Monte Carlo (MCMC) methods, including the force of infection, effective reproduction number ( R t ), and incubation periods. The model revealed significant underreporting, with only 10–24% of infections documented, 23% of which presented with clinical symptoms. These findings underscore the importance of including competence and imperfect detection in disease models to depict outbreak dynamics and inform effective control strategies accurately. As a baseline model, this SEIR-SEI implementation is intended to serve as a foundation for future refinements and expansions to improve our understanding of VS dynamics. Enhanced surveillance and targeted interventions are recommended to manage future VS outbreaks. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Interrogating Genomes and Geography to Unravel Multiyear Vesicular Stomatitis Epizootics.

Author

Humphreys, John M., Shults, Phillip T., Velazquez-Salinas, Lauro, Bertram, Miranda R., Pelzel-McCluskey, Angela M., Pauszek, Steven J., Peters, Debra P. C., and Rodriguez, Luis L.

Subjects
VESICULAR stomatitis, VIRAL variation, VIRUS diversity, VECTOR-borne diseases, SUMMER
Abstract

We conducted an integrative analysis to elucidate the spatial epidemiological patterns of the Vesicular Stomatitis New Jersey virus (VSNJV) during the 2014–15 epizootic cycle in the United States (US). Using georeferenced VSNJV genomics data, confirmed vesicular stomatitis (VS) disease cases from surveillance, and a suite of environmental factors, our study assessed environmental and phylogenetic similarity to compare VS cases reported in 2014 and 2015. Despite uncertainties from incomplete virus sampling and cross-scale spatial processes, patterns suggested multiple independent re-invasion events concurrent with potential viral overwintering between sequential seasons. Our findings pointed to a geographically defined southern virus pool at the US–Mexico interface as the source of VSNJV invasions and overwintering sites. Phylodynamic analysis demonstrated an increase in virus diversity before a rise in case numbers and a pronounced reduction in virus diversity during the winter season, indicative of a genetic bottleneck and a significant narrowing of virus variation between the summer outbreak seasons. Environment–vector interactions underscored the central role of meta-population dynamics in driving disease spread. These insights emphasize the necessity for location- and time-specific management practices, including rapid response, movement restrictions, vector control, and other targeted interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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8. An Integrated View of Complex Landscapes : A Big Data-Model Integration Approach to Transdisciplinary Science

Author

PETERS, DEBRA P.C., BURRUSS, N. DYLAN, RODRIGUEZ, LUIS L., MCVEY, D. SCOTT, ELIAS, EMILE H., PELZEL-MCCLUSKEY, ANGELA M., DERNER, JUSTIN D., SCHRADER, T. SCOTT, YAO, JIN, PAUSZEK, STEVEN J., LOMBARD, JASON, ARCHER, STEVEN R., BESTELMEYER, BRANDON T., BROWNING, DAWN M., BRUNGARD, COLBY W., HATFIELD, JERRY L., HANAN, NIALL P., HERRICK, JEFFREY E., OKIN, GREGORY S., SALA, OSVALDO E., SAVOY, HEATHER, and VIVONI, ENRIQUE R.

Published
2018

9. Discovery of a novel species, Theileria haneyi n. sp., infective to equids, highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance

Author

Knowles, Donald P., Kappmeyer, Lowell S., Haney, Darrell, Herndon, David R., Fry, Lindsay M., Munro, James B., Sears, Kelly, Ueti, Massaro W., Wise, Lauren N., Silva, Marta, Schneider, David A., Grause, Juanita, White, Stephen N., Tretina, Kyle, Bishop, Richard P., Odongo, David O., Pelzel-McCluskey, Angela M., Scoles, Glen A., Mealey, Robert H., and Silva, Joana C.

Published
2018
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12. Contributors

Author

Abutarbush, Sameeh M., primary, Aceto, Helen, additional, Affolter, Verena K., additional, Albanese, Valeria, additional, Aleman, Monica, additional, Allen, Kate, additional, Allen, Kent, additional, Alvarenga, Marco Antonio, additional, Andrews, Frank M., additional, Annear, Matthew, additional, Banse, Heidi, additional, Barrett, Elizabeth J., additional, Bauck, Anje G., additional, Beard, Laurie A., additional, Beard, Warren, additional, Belgrave, Rodney L., additional, Blanchard, Terry L., additional, Blott, Sarah, additional, Brandt, Sabine, additional, Branson, Keith R., additional, Brink, Palle, additional, Brockus, Charles W., additional, Brown, James A., additional, Buchanan, Benjamin R., additional, Buhl, Rikke, additional, Burba, Daniel J., additional, Burden, Faith, additional, Burns, Teresa A., additional, Camacho-Luna, Pilar, additional, Canisso, Igor F., additional, Carlson, Kelly L., additional, Carr, Elizabeth A., additional, Chapman, Hannah-Sophie, additional, Claes, Anthony, additional, Clayton, Hilary M., additional, Clode, Alison B., additional, Coleman, Michelle C., additional, Contino, Erin K., additional, Cook, R. Frank, additional, Cook, Vanessa L., additional, Corley, Kevin T., additional, Cullinane, Ann, additional, Coutinho da Silva, Marco A., additional, Dahlgren, Linda A., additional, Dart, Andrew J., additional, Davidson, Elizabeth J., additional, Davis, Elizabeth, additional, Dechant, Julie E., additional, Diaz-Méndez, Andrés, additional, Divers, Thomas J., additional, du Toit, Nicole, additional, Dunkel, Bettina, additional, Durham, Matthew G., additional, Dyson, Sue, additional, Eastman, Tim G., additional, Elton, Debra, additional, Epstein, Kira L., additional, Estell, Krista E., additional, Ewart, Susan L., additional, Ferris, Ryan A., additional, Fielding, C. Langdon, additional, Finan, Seán A., additional, Finno, Carrie J., additional, Fowlie, Jennifer, additional, Frank, Nicholas, additional, Franklin, Samantha H., additional, Frazer, Michele L., additional, Freeman, David E., additional, Furr, Martin, additional, Garrett, Katherine S., additional, Gilger, Brian C., additional, Gillis, Carol L., additional, Gimenez, Rebecca M., additional, Giuliano, Elizabeth A., additional, Goehring, Lutz S., additional, Goodrich, Laurie R., additional, Graves, Emily A., additional, Guthrie, Alan J., additional, Hackett, Eileen S., additional, Hahn, Caroline, additional, Hainisch, Edmund K., additional, Hanson, R. Reid, additional, Hart, Kelsey A., additional, Haussler, Kevin K., additional, Henninger, Rick W., additional, Hogan, Patricia M., additional, Hollis, Anna R., additional, Hurcombe, Samuel D.A., additional, Issel, Charles J., additional, Jesty, Sophy A., additional, Johnson, Amy L., additional, Johnson, Philip J., additional, Jokisalo, Jonna M., additional, Kamm, J. Lacy, additional, Katz, Lisa Michelle, additional, Knych, Heather K., additional, Labelle, Amber L., additional, Lacombe, Véronique A., additional, Landolt, Gabriele A., additional, Léguillette, Renaud, additional, Leutenegger, Christian M., additional, Lorch, Gwendolen, additional, Losinno, Luis, additional, Lugo, Joel, additional, Macpherson, Margo L., additional, Madigan, John E., additional, Magdesian, K. Gary, additional, Mair, Tim, additional, Mama, Khursheed R., additional, Marsella, Rosanna, additional, Mason, Clara Ann, additional, Matthews, Nora S., additional, McCarrel, Taralyn M., additional, McCluskey, Brian J., additional, McConnico, Rebecca S., additional, McCracken, Jeanette L., additional, McCue, Patrick M., additional, McGorum, Bruce C., additional, McGurrin, M. Kimberly J., additional, McKenzie, Harold C., additional, McKinnon, Angus O., additional, McNabb, Noelle T., additional, Meindel, Mandy J., additional, Mendes, Luiz Claudio Nogueira, additional, Millerick-May, Melissa L., additional, Morehead, James P., additional, Morresey, Peter R., additional, Morrison, Scott E., additional, Morton, Alison J., additional, Mowat, Freya M., additional, Murray, Rachel C., additional, Natalini, Claudio C., additional, Nelson, Brad B., additional, Neto, Carlos Ramires, additional, Newcombe, John R., additional, Newton, J. Richard, additional, Nielsen, Martin K., additional, O'Brien, Philippa, additional, O'Grady, Stephen E., additional, O'Neill, Henry D., additional, Oosterlinck, Maarten, additional, Paccamonti, Dale L., additional, Page, Allen E., additional, Papa, Frederico Ozanam, additional, Parkin, Tim D.H., additional, Parks, Andrew H., additional, Pease, Anthony P., additional, Peek, Simon F., additional, Pelzel-McCluskey, Angela M., additional, Perkins, Justin D., additional, Peroni, John F., additional, Peters, Duncan F., additional, Petersen, Annette, additional, Phillips, Jeffrey, additional, Plummer, Caryn E., additional, Powell, Sarah E., additional, Pozor, Malgorzata, additional, Prange, Timo, additional, Puschner, Birgit, additional, Pusterla, Nicola, additional, Pynn, Oliver D., additional, Ragle, Claude A., additional, Rashmir-Raven, Ann, additional, Reed, Stephen M., additional, Richter, Ruth-Anne, additional, Robinson, N. Edward, additional, Rombach, Nicole, additional, Ruggles, Alan J., additional, Runcan, Erin E., additional, Schott, Harold C., additional, Schroeder, Eric L., additional, Schumacher, John, additional, Schumacher, Stephen A., additional, Scoggin, Charles F., additional, Sellon, Debra C., additional, Sherlock, Ceri, additional, Sinclair, Charlotte, additional, Sinclair, Melissa, additional, Slovis, Nathan, additional, Soboll Hussey, Gisela, additional, Spier, Sharon J., additional, Sponseller, Beatrice T., additional, Sprayberry, Kim A., additional, Stack, Alice, additional, Stick, John, additional, Stover, Susan M., additional, Stratford, Claire H., additional, Stubbs, Narelle Colleen, additional, Taintor, Jennifer S., additional, Thiemann, Alexandra K., additional, Timoney, John F., additional, Toribio, Ramiro E., additional, Tranquille, Carolyne A., additional, Traub-Dargatz, Josie L., additional, Tulloch, Laura K., additional, Utter, Mary Lassaline, additional, van den Top, Gerald, additional, Varner, Dickson D., additional, Viel, Laurent, additional, von Schweinitz, Dietrich Graf, additional, Waldridge, Bryan M., additional, Walker, Vicki A., additional, Watts, Ashlee E., additional, Werner, Laura A., additional, Weyer, Camilla T., additional, White, Stephen D., additional, Wilkerson, Melinda J., additional, Wilkins, Pamela A., additional, Wilson, M. Eilidh, additional, Wilson, Pamela J., additional, Witte, Thomas H., additional, Wong, David M., additional, and Yiannikouris, Stavros, additional

Published
2015
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15. Surveillance along the Rio Grande during the 2020 Vesicular Stomatitis Outbreak Reveals Spatio-Temporal Dynamics of and Viral RNA Detection in Black Flies

Author

Young, Katherine I., primary, Valdez, Federico, additional, Vaquera, Christina, additional, Campos, Carlos, additional, Zhou, Lawrence, additional, Vessels, Helen K., additional, Moulton, J. Kevin, additional, Drolet, Barbara S., additional, Rozo-Lopez, Paula, additional, Pelzel-McCluskey, Angela M., additional, Peters, Debra C., additional, Rodriguez, Luis L., additional, and Hanley, Kathryn A., additional

Published
2021
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16. Integrating Spatiotemporal Epidemiology, Eco-Phylogenetics, and Distributional Ecology to Assess West Nile Disease Risk in Horses

Author

Humphreys, John M., primary, Pelzel-McCluskey, Angela M., additional, Cohnstaedt, Lee W., additional, McGregor, Bethany L., additional, Hanley, Kathryn A., additional, Hudson, Amy R., additional, Young, Katherine I., additional, Peck, Dannele, additional, Rodriguez, Luis L., additional, and Peters, Debra P. C., additional

Published
2021
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17. Big data–model integration and AI for vector‐borne disease prediction

Author

Peters, Debra P. C., primary, McVey, D. Scott, additional, Elias, Emile H., additional, Pelzel‐McCluskey, Angela M., additional, Derner, Justin D., additional, Burruss, N. Dylan, additional, Schrader, T. Scott, additional, Yao, Jin, additional, Pauszek, Steven J., additional, Lombard, Jason, additional, and Rodriguez, Luis L., additional

Published
2020
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19. Serum Antibodies from a Subset of Horses Positive for Babesia caballi by Competitive Enzyme-Linked Immunosorbent Assay Demonstrate a Protein Recognition Pattern That Is Not Consistent with Infection

Author

Awinda, Peter O., primary, Mealey, Robert H., additional, Williams, Laura B. A., additional, Conrad, Patricia A., additional, Packham, Andrea E., additional, Reif, Kathryn E., additional, Grause, Juanita F., additional, Pelzel-McCluskey, Angela M., additional, Chung, Chungwon, additional, Bastos, Reginaldo G., additional, Kappmeyer, Lowell S., additional, Howe, Daniel K., additional, Ness, SallyAnne L., additional, Knowles, Donald P., additional, and Ueti, Massaro W., additional

Published
2013
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21. Serum Antibodies from a Subset of Horses Positive for Babesia caballiby Competitive Enzyme-Linked Immunosorbent Assay Demonstrate a Protein Recognition Pattern That Is Not Consistent with Infection

Author

Awinda, Peter O., Mealey, Robert H., Williams, Laura B. A., Conrad, Patricia A., Packham, Andrea E., Reif, Kathryn E., Grause, Juanita F., Pelzel-McCluskey, Angela M., Chung, Chungwon, Bastos, Reginaldo G., Kappmeyer, Lowell S., Howe, Daniel K., Ness, SallyAnne L., Knowles, Donald P., and Ueti, Massaro W.

Abstract

ABSTRACTTick-borne pathogens that cause persistent infection are of major concern to the livestock industry because of transmission risk from persistently infected animals and the potential economic losses they pose. The recent reemergence of Theileria equiin the United States prompted a widespread national survey resulting in identification of limited distribution of equine piroplasmosis (EP) in the U.S. horse population. This program identified Babesia caballi-seropositive horses using rhoptry-associated protein 1 (RAP-1)–competitive enzyme-linked immunosorbent assay (cELISA), despite B. caballibeing considered nonendemic on the U.S. mainland. The purpose of the present study was to evaluate the suitability of RAP-1–cELISA as a single serological test to determine the infection status of B. caballiin U.S. horses. Immunoblotting indicated that sera from U.S. horses reacted with B. caballilysate and purified B. caballiRAP-1 protein. Antibody reactivity to B. caballilysate was exclusively directed against a single ~50-kDa band corresponding to a native B. caballiRAP-1 protein. In contrast, sera from experimentally and naturally infected horses from regions where B. caballiis endemic bound multiple proteins ranging from 30 to 50 kDa. Dilutions of sera from U.S. horses positive by cELISA revealed low levels of antibodies, while sera from horses experimentally infected with B. caballiand from areas where B. caballiis endemic had comparatively high antibody levels. Finally, blood transfer from seropositive U.S. horses into naive horses demonstrated no evidence of B. caballitransmission, confirming that antibody reactivity in cELISA-positive U.S. horses was not consistent with infection. Therefore, we conclude that a combination of cELISA and immunoblotting is required for the accurate serodiagnosis of B. caballi.

Published
2013
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