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14 results on '"Pena, Matthew"'

7. Assessing Surgical Task Load and Performance: A Comparison of Simulation and Maritime Operation

Author

Spitzer, Holly V, primary, Hoang, Tuan, additional, Pierce, Eric, additional, Franciose, Reginald J, additional, Pena, Matthew, additional, Shattuck, Nita L, additional, Bass, Cameron R, additional, Blankenship, Jeffrey, additional, Juliano, Michael, additional, Lindemann, Cameron B, additional, Springer, Hayden A, additional, and LaPorta, Anthony J, additional

Published
2020
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8. Effects of Fatigue on Surgical Performance and Attentiveness

Author

Spitzer, Holly, primary, Hoang, Tuan, additional, Lindemann, Cameron, additional, LaPorta, Anthony J., additional, Pierce, Eric C., additional, Pena, Matthew T., additional, Franciose, Reginald J., additional, Bass, Cameron R., additional, and Shattuck, Nita L., additional

Published
2018
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10. Pheromone-induced morphogenesis and gradient tracking are dependent on the MAPK Fus3 binding to G

Author

Ford, Eintou, Elston, Timothy C., Vered, Lior, Pena, Matthew I., and Errede, Beverly

Abstract

Mitogen-activated protein kinase (MAPK) pathways control many cellular processes, including differentiation and proliferation. These pathways commonly activate MAPK isoforms that have redundant or overlapping function. However, recent studies have revealed circumstances in which MAPK isoforms have specialized, nonoverlapping roles in differentiation. The mechanisms that underlie this specialization are not well understood. To address this question, we sought to establish regulatory mechanisms that are unique to the MAPK Fus3 in pheromone-induced mating and chemotropic fate transitions of the budding yeast Saccharomyces cerevisiae. Our investigations reveal a previously unappreciated role for inactive Fus3 as a potent negative regulator of pheromone-induced chemotropism. We show that this inhibitory role is dependent on inactive Fus3 binding to the α-subunit of the heterotrimeric G-protein. Further analysis revealed that the binding of catalytically active Fus3 to the G-protein is required for gradient tracking and serves to suppress cell-to-cell variability between mating and chemotropic fates in a population of pheromone-responding cells.

Published
2015
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14. Chicago.

Author

de la Pena, Matthew

Abstract

The article reviews the revival of William Shakespeare's "Othello" by the Joffrey Ballet with the original composition of Elliot Goldenthal and original choreography by Lar Lubovitch, performed at the Auditorium Theatre in Chicago on May 5, 2013.

Published
2013

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