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301 results on '"Pena, Y."'

5. Simplified risk-prediction for benchmarking and quality improvement in emergency general surgery. Prospective, multicenter, observational cohort study

Author

Afonso, N., Aguilella, V., Aguiló, J., Alados, J.C., Alberich, M., Apio, A.B., Balongo, R., Bra, E., Bravo-Gutiérrez, A., Briceño, F.J., Cabañas, J., Cánovas, G., Caravaca, I., Carbonell, S., Carrera-Dacosta, E., Castro E, E., Caula, C., Choolani-Bhojwani, E., Codina, A., Corral, S., Cuenca, C., Curbelo-Peña, Y., Delgado-Morales, M.M., Delgado-Plasencia, L., Doménech, E., Estévez, A.M., Feria, A.M., Gascón-Domínguez, M.A., Gianchandani, R., González, C., Hevia, R.J., González, M.A., Hidalgo, J.M., Lainez, M., Lluís, N., López, F., López-Fernández, J., López-Ruíz, J.A., Lora-Cumplido, P., Madrazo, Z., Marchena, J., Marenco de la Cuadra, B., Martín, S., Casas, I. Martínez, Martínez, P., Mena-Mateos, A., Morales-García, D., Mulas, C., Muñoz-Forner, E., Naranjo, A., Navarro-Sánchez, A., Oliver, I., Ortega, I., Ortega-Higueruelo, R., Ortega-Ruiz, S., Osorio, J., Padín, M.H., Pamies, J.J., Paredes, M., Pareja-Ciuró, F., Parra, J., Pérez-Guarinós, C.V., Pérez-Saborido, B., Pintor-Tortolero, J., Plua-Muñiz, K., Rey, M., Rodríguez, I., Ruiz, C., Ruíz, R., Ruiz, S., Sánchez, A., Sánchez, D., Sánchez, R., Sánchez-Cabezudo, F., Sánchez-Santos, R., Santos, J., Serrano-Paz, M.P., Soria-Aledo, V., Tallón-Aguilar, L., Valdivia-Risco, J.H., Vallverdú-Cartié, H., Varela, C., Villar-del-Moral, J., Zambudio, N., Villodre, C., Taccogna, L., Zapater, P., Cantó, M., Mena, L., Ramia, J.M., and Lluís, F.

Published
2022
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8. Linfoma anaplásico de células grandes asociado a implantes mamarios. Documento de consenso (I): epidemiología, patogenia, clínica y diagnóstico

Author

Acea, B., Albi, B., Albi, M., Andrés-Luna, R., Ara, C., Arranz, M., Caba, M., Camps, J., Carcamo, C., Ciérvide, R., Comin, L., Cordeiro, P., de Castro, G., Delgado, M., Durán Poveda, M., Estelles, N., Estrada, N., Fernández, E., Fuster, G., García-Foncillas, J., García, I., García Mur, C., Garcia Pardo, L., Gil Olarte, M.A., Gómez, M.T., González, A., Gutierrez, I., Hernanz, F., Izarzugaza, Y., Jimeno, J., Lobo, F., Martínez, D., Martínez, M., Martínez, R., Matei, P., Masià, J., Menjón, S., Murillo, J., Orihuela, P., Osorio, I., Lillo, A. Peña y, Pérez, S., Pinardo, A., Piris, M.A., Pla, M.J., Ramón y Cajal, T., Ramos, M., Ramos, T., Rivas, S., Rodriguez, I., Rodriguez, N., Romero, C., Rojo, F., Sanroman, J.M., Sanz, J., Salvatierra, V., Salido, S., Sánchez, J.I., Serra, J.M., Serrano, C., Socorro, M., Tejerina, Alejandro, Tejerina, Antonio, Treserra, F., Valadas, G., Vernet, M., Vega, V., Vidal, S., Zarain, L., Pardo, Ricardo, Quintana, Rosa, Piñero, Antonio, Vázquez, Carlos, Cabañas, Jacobo, Martínez Regueira, Fernando, Bernet, Laia, Rioja, María Eugenia, Rabadán, Lorenzo, Barriga, Raquel, Mallent, José, Urruticoetxea, Ander, Algara, Manel, Montero, Ángel, Palomo, Teresa, Llamas, Pilar, and Córdoba, Raúl

Published
2019
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9. Linfoma anaplásico de células grandes asociado a implantes mamarios. Documento de consenso parte II: estadificación, tratamiento, pronóstico y seguimiento

Author

Acea, B., Albi, B., Albi, M., Andrés-Luna, R., Ara, C., Arranz, M., Caba, M., Camps, J., Carcamo, C., Ciérvide, R., Comin, L., Cordeiro, P., De Castro, G., Delgado, M., Durán Poveda, M., Estelles, N., Estrada, N., Fernández, E., Fuster, G., García-Foncillas, J., García, I., García Mur, C., García Pardo, L., Gil Olarte, M.A., Gómez, M.T., González, A., Gutierrez, I., Hernanz, F., Izarzugaza, Y., Jimeno, J., Lobo, F., Martínez, D., Martínez, M., Martínez, R., Matei, P., Masià, J., Menjón, S., Murillo, J., Orihuela, P., Osorio, I., Peña y Lillo, A., Pérez, S., Pinardo, A., Piris, M.A., Pla, M.J., Ramón y Cajal, T., Ramos, M., Ramos, T., Rivas, S., Rodriguez, I., Rodríguez, N., Romero, C., Rojo, F., Sanromán, J.M., Sanz, J., Salvatierra, V., Salido, S., Sánchez, J.I., Serra, J.M., Serrano, C., Socorro, M., Alejandro, Tejerina, Antonio, Tejerina, Treserra, F., Valadas, G., Vernet, M., Vega, V., Vidal, S., Zarain, L., Pardo, Ricardo, Quintana, Rosa, Piñero, Antonio, Vázquez, Carlos, Cabañas, Jacobo, Martínez Regueira, Fernando, Palomo, Teresa, Llamas, Pilar, Córdoba, Raúl, Rabadán, Lorenzo, Barriga, Raquel, Mallent, José, Urruticoetxea, Ander, Algara, Manel, Montero, Ángel, Bernet, Laia, and Rioja, María Eugenia

Published
2019
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10. Rewiring yeast metabolism for producing 2,3-butanediol and two downstream applications: Techno-economic analysis and life cycle assessment of methyl ethyl ketone (MEK) and agricultural biostimulant production

Author

Lee, J, Bhagwat, S, Kuanyshev, N, Cho, Y, Sun, L, Lee, Y, Cortes-Pena, Y, Li, Y, Rao, C, Guest, J, Jin, Y, Lee J. W., Bhagwat S. S., Kuanyshev N., Cho Y. B., Sun L., Lee Y. -G., Cortes-Pena Y. R., Li Y., Rao C. V., Guest J. S., Jin Y. -S., Lee, J, Bhagwat, S, Kuanyshev, N, Cho, Y, Sun, L, Lee, Y, Cortes-Pena, Y, Li, Y, Rao, C, Guest, J, Jin, Y, Lee J. W., Bhagwat S. S., Kuanyshev N., Cho Y. B., Sun L., Lee Y. -G., Cortes-Pena Y. R., Li Y., Rao C. V., Guest J. S., and Jin Y. -S.

Abstract

Rising concerns for sustainability and global climate change have driven the development of sustainable production pathways for biofuels and chemicals from lignocellulosic biomass via integrated biological and chemical processes. We constructed an engineered Saccharomyces cerevisiae capable of producing 2,3-butanediol (2,3-BDO) from glucose without accumulating ethanol and glycerol, which hinder downstream processing of 2,3-BDO, through extensive metabolic reprogramming. Specifically, we introduced heterologous 2,3-BDO biosynthetic enzymes and deleted the major isozymes of ethanol and glycerol biosynthetic enzymes. In addition, we introduced an NAD+ regenerating Pyruvate-Malate (PM) cycle and enhanced the NAD+ regenerating capability of the PM cycle to resolve the redox imbalance from the deletion of ethanol and glycerol production pathways. The resulting engineered yeast produced 109.9 g/L of 2,3-BDO with a productivity of 1.0 g/L/h and a yield of 0.36 g/g glucose in a fed-batch fermentation. We also conducted techno-economic analysis (TEA) and life cycle assessment (LCA) of the production of methyl ethyl ketone (MEK) through catalytic dehydration of 2,3-BDO. A TEA based on the experimental results indicated that the minimum product selling price (MPSP) was estimated to be $1.90/kg. Regarding cradle-to-grave LCA, 100-year global warming potential (GWP100) and fossil energy consumption (FEC) were found to be 0.37 kg CO2 eq/kg and 3.1 MJ/kg, respectively. These results demonstrated the feasibility of cost-competitive and sustainable bio-based MEK production via yeast fermentation. In addition, we explored the possibility of using the fermentation broth containing 2,3-BDO as a biostimulant inducing drought tolerance in plants. As a result, the yeast 2,3-BDO fermentation broth can induce drought tolerance in Arabidopsis thaliana without a complicated purification process.

Published
2023

16. List of Contributors

Author

Aymerich-Franch, Laura, primary, Bailenson, Jeremy N., additional, Brew-Sam, Nicola, additional, Britt, Rebecca K., additional, Calabrese, Christopher, additional, Chang, Pamara F., additional, Chib, Arul, additional, Chignell, Mark, additional, Cramer, Emily M., additional, Fauville, Géraldine, additional, Fisher, Jacob T., additional, Hayes, Jameson L., additional, Hether, Heather J., additional, Isabell, Koinig, additional, Jang, Jeong-woo, additional, Kanthawala, Shaheen, additional, Khan, Subuhi, additional, Kuang, Kai, additional, Lee, Chul-joo, additional, Lee, SongYi, additional, Li, Benjamin J., additional, Liao, Tony, additional, Maddox, Jessica, additional, Marsh, Alexis K., additional, Moller, Henry, additional, Pandita, Swati, additional, Peña, Jorge, additional, Pena-y-Lillo, Macarena, additional, Queiroz, Anna Carolina Muller, additional, Ratan, Rabindra, additional, Sandra, Diehl, additional, Van Stee, Stephanie K., additional, Wang, Ningxin, additional, Waterworth, John A., additional, Weber, René, additional, Won, Andrea Stevenson, additional, and Yang, Qinghua, additional

Published
2020
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17. Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits

Author

Saul Herranz-Martin, Jayanth Chandran, Katherine Lewis, Padraig Mulcahy, Adrian Higginbottom, Callum Walker, Isabel Martinez-Pena y Valenzuela, Ross A. Jones, Ian Coldicott, Tommaso Iannitti, Mohammed Akaaboune, Sherif F. El-Khamisy, Thomas H. Gillingwater, Pamela J. Shaw, and Mimoun Azzouz

Subjects
C9orf72, Neurodegeneration, ALS/FTD, Mouse model, C9RAN aggregates, Medicine, Pathology, RB1-214
Abstract

Intronic GGGGCC repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been identified in postmortem tissue: intracellular RNA foci and repeat-associated non-ATG dependent (RAN) dipeptides, although it is unclear how these and other hallmarks of disease contribute to the pathophysiology of neuronal injury. Here, we describe two novel lines of mice that overexpress either 10 pure or 102 interrupted GGGGCC repeats mediated by adeno-associated virus (AAV) and recapitulate the relevant human pathology and disease-related behavioural phenotypes. Similar levels of intracellular RNA foci developed in both lines of mice, but only mice expressing 102 repeats generated C9orf72 RAN pathology, neuromuscular junction (NMJ) abnormalities, dispersal of the hippocampal CA1, enhanced apoptosis, and deficits in gait and cognition. Neither line of mice, however, showed extensive TAR DNA-binding protein 43 (TDP-43) pathology or neurodegeneration. Our data suggest that RNA foci pathology is not a good predictor of C9orf72 RAN dipeptide formation, and that RAN dipeptides and NMJ dysfunction are drivers of C9orf72 disease pathogenesis. These AAV-mediated models of C9orf72-associated ALS/FTD will be useful tools for studying disease pathophysiology and developing new therapeutic approaches.

Published
2017
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20. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19

Author

Einstein, A, Hirschfeld, C, Williams, M, Vitola, J, Better, N, Villines, T, Cerci, R, Shaw, L, Choi, A, Dorbala, S, Karthikeyan, G, Lu, B, Sinitsyn, V, Ansheles, A, Kudo, T, Bucciarelli-Ducci, C, Norgaard, B, Maurovich-Horvat, P, Campisi, R, Milan, E, Louw, L, Allam, A, Bhatia, M, Sewanan, L, Malkovskiy, E, Cohen, Y, Randazzo, M, Narula, J, Morozova, O, Pascual, T, Pynda, Y, Dondi, M, Paez, D, Hinterleitner, G, Lu, Y, Xu, Z, Erinne, I, Shetty, M, Lopez-Mattei, J, Parwani, P, Goda, A, Shirka, E, Bouyoucef, S, Chelghoum, L, Mansouri, F, Medjahedi, A, Naili, Q, Ridouh, M, Alasia, D, Alberghina, L, Aramayo, N, Buchara, D, Busso, F, Bustos Rivadero, J, Camilletti, J, Campanelli, H, Castro, R, Daicz, M, del Riego, H, Dragonetti, L, Echazarreta, D, Erriest, J, Faccio, F, Facello, A, Gallegos, H, Geronazzo, R, Glait, H, Hasbani, V, Jager, V, Lewkowicz, J, Lotti, J, Maciel, N, Masoli, O, Mastrovito, E, Medus, M, Merani, M, Molteni, S, Montecinos, M, Parisi, G, Sueldo, C, Perez de Arenaza, D, Quintana, L, Radzinschi, A, Redruello, M, Rodriguez, M, Rojas, H, Acuna, A, Schere, D, Traverso, S, Vazquez, G, Zeffiro, S, Sakanyan, M, Beuzeville, S, Boktor, R, Crowley, M, Downie, D, Dwivedi, G, Elison, B, Farouque, O, Jasper, K, Joshi, S, Lee, J, Lee, K, Lui, E, Mcconachie, P, Meaker, J, Nandurkar, D, Neill, J, O'Rourke, E, O'Sullivan, P, Pandos, G, Premaratne, M, Prior, D, Rutherford, N, Saunders, C, Taubman, K, Tauro, A, Taylor, A, Theuerle, J, Thomas, P, Tow, J, Upton, A, Vamadevan, S, Wayne, V, Wegner, E, Wong, D, Younger, J, Beitzke, D, Feuchtner, G, Sommer, O, Weiss, K, Maroz-Vadalazhskaya, N, Tserakhau, U, Homans, F, Van De Heyning, C, Araujo, R, Soldat-Stankovic, V, Stankovic, S, Almeida, A, Anselmi, C, Azevedo, G, Bittencourt, M, Pianta, D, Cabeda, E, Carreira, L, Coelho, I, de Amorim Fernandes, F, de Lorenzo, A, Delgado, R, Erthal, F, Fernandes, F, Fernandes, J, Ferreira de Souza, T, Foppa, M, Matos Alves, W, Gontijo, C, Gottlieb, I, Grossman, G, Albernaz Siqueira, M, Nomura, C, Koga, K, Lima, R, Lopes, R, Marcal Filho, H, Masiero, P, Mastrocola, L, Menezes de Siqueira, M, Mesquita, C, Naves, D, Penna, F, Pinto, I, Rocha, T, Rocha, J, Rodrigues, A, Salioni, L, Sanches, A, Santos, M, Da Silva, L, Schvartzman, P, Matushita, C, Senra, T, Silva, M, Soares, C, Spiro, B, Suaide Silva, C, Torres, R, Monte, G, Vilela, A, Villa, A, Voss, T, Waltrick, R, Zapparoli, M, Naseer, H, Garcheva-Tsacheva, M, Ouattara, T, Thou, S, Varoeun, S, Abikhzer, G, Beanlands, R, Chetrit, M, Dabreo, D, Dennie, C, Friedrich, M, Hafez, M, Hanneman, K, Miller, R, Oikonomou, A, Roifman, I, Small, G, Tandon, V, Trivedi, A, White, J, Zukotynski, K, Alay, R, Concha, C, Massardo, T, Abad, P, Anzola, K, Arturo, H, Benitez, L, Cadena, A, Zamudio, C, Calderon, A, Gutierrez Villamil, C, Jaimes, C, Londono, J, Lopez, N, Merlano-Gaitan, S, Murgieitio-Cabrera, R, Valencia, M, Vergel, D, Santamaria, A, Solis, F, Batinic, T, Franceschi, M, Paar, M, Prpic, M, Felipe Batista, C, Cabrera, L, Peix, A, Pena, Y, Rochela Vazquez, L, Ntalas, I, Kaminek, M, Kincl, V, Lang, O, Abdulla, J, Bottcher, M, Busk, M, Geisler, U, Gormsen, L, Hansson, N, Hess, S, Hove, J, Jensen, L, Jensen, M, Kragholm, K, Ovrehus, K, Rasmussen, J, Ronnow Sand, N, Sondergaard, H, Zaremba, T, Speckter, H, Amores, N, Velez, M, Alrahman, T, Elsamad, S, Abdelfattah, A, Elkaffas, S, Hassan, M, Hussein, E, Ibrahim, A, Kandeel, A, Ali, M, Shaaban, M, Flores, C, Gomez Leiva, V, Liiver, A, Larikka, M, Uusitalo, V, Agostini, D, Berger, C, Dietz, M, Hyafil, F, Ohana, M, Prigent, K, Regaieg, H, Sarda-Mantel, L, H-Ici, D, Ayetey, H, Angelidis, G, Fragkaki, C, Fragkiadaki, C, Georgoulias, P, Koutelou, M, Kyrozi, E, Lama, N, Prassopoulos, V, Spartalis, M, Zaglavara, T, Gonzalez, C, Gutierrez, G, Maldonado, A, Martinez, Y, Kovacs, A, Szilveszter, B, Banthia, N, Bhat, V, Choudhury, P, Chowdekar, V, Christopher, J, Garg, T, Goyal, N, Gupta, R, Gupta, A, Hephzibah, J, Jain, S, Krupa, J, Kumar, P, Kumar, S, Lalchandani, A, Mishra, A, Mishra, V, Mohan, P, Ozair, A, Pandey, S, Parameswaran, R, Patel, C, Patel, T, Patel, S, Vimala, L, Kumar Sarangi, D, Sengupta, S, Sethi, A, Sharma, A, Sharma, P, Shrigiriwar, A, Singh, S, Singh, H, Sood, A, Verma, A, Vyas, A, Soeriadi, E, Bun, E, Hutomo, F, Syawaluddin, H, Yudistiro, R, Albadr, A, Assadi, M, Emami, F, Emami-Ardekani, A, Farzanehfar, S, Jafari, R, Manafi-Farid, R, Tajik, M, Arnson, Y, Fuchs, S, Goldkorn, R, Kennedy, J, Leitman, M, Shalev, A, Acampa, W, Albano, D, Alongi, P, Arnone, G, Assante, R, Baritussio, A, Bauckneht, M, Bianco, F, Bonfiglioli, R, Bovenzi, F, Bruno, I, Bruno, A, Busnardo, E, Califaretti, E, Casoni, R, Censullo, V, Chierichetti, F, Chiocchi, M, Cittanti, C, Clemente, A, Cuocolo, A, De Rimini, M, De Vincentis, G, Della Tommasina, V, Dellegrottaglie, S, Erba, P, Evangelista, L, Faggi, L, Faragasso, E, Florimonte, L, Frantellizzi, V, Gatti, M, Gaudiano, A, Gelardi, F, Gerali, A, Gimelli, A, Guglielmo, M, Leccisotti, L, Liga, R, Liguori, C, Longo, G, Maffione, M, Marcassa, C, Matassa, G, Mele, D, Mircoli, L, Paccagnella, A, Pacella, S, Padovano, F, Pellegrini, D, Pergola, V, Pugliese, L, Quartuccio, N, Rampin, L, Ricci, F, Rubini, G, Russo, V, Sambuceti, G, Scatteia, A, Sciagra, R, Spidalieri, G, Stefanelli, A, Tedeschi, C, Ventroni, G, Baugh, D, Madu, E, Aikawa, T, Asano, H, Fujimoto, S, Fujise, K, Fukushima, Y, Fukuyama, K, Ichikawa, Y, Ideguchi, R, Iguchi, N, Imai, M, Ishimura, H, Isobe, S, Ito, K, Izawa, Y, Kadokami, T, Kasai, T, Kato, T, Kawamoto, T, Kiryu, S, Kumita, S, Manabe, O, Maruno, H, Matsumoto, N, Miyagawa, M, Moroi, M, Nagamachi, S, Nakajima, K, Nakazato, R, Nanasato, M, Naya, M, Norikane, T, Ohta, Y, Otomi, Y, Otsuka, H, Oyama-Manabe, N, Saito, M, Sarai, M, Sato, J, Sato, D, Shiraishi, S, Takanami, K, Takehana, K, Taniguchi, Y, Teragawa, H, Tomizawa, N, Umeji, K, Wakabayashi, Y, Yamada, S, Yamazaki, S, Yoneyama, T, Rawashdeh, M, Dautov, T, Makhdomi, K, Abass, M, Garashi, M, Siraj, Q, Kalnina, M, Haidar, M, Komiagiene, R, Kviecinskiene, G, Vajauskas, D, Karim, N, Doucoure, M, Reichmuth, L, Samuel, A, Dieng, M, Naojee, A, Hernandez, E, Alducin Tellez, C, Alexanderson-Rosas, E, Barragan, E, Cabada, M, Calderon, D, Carvajal-Juarez, I, Esparza, J, Gama-Moreno, M, Quinto, V, Gonzalez, N, Herrera-Zarza, M, Meave, A, Medina Verdugo, J, Melendez, G, Morales Murguia, R, Navarro Quiroz, C, Ornelas, M, Preciado-Anaya, A, Preciado-Gutierrez, O, Puente, A, Salazar, A, Rosales Uvera, S, Rosales-Uvera, S, Serna Macias, J, Sierra-Galan, L, Tirado Alderete, J, Vallejo, E, Faraggi, M, Sereegotov, E, Ben Rais, N, Alaoui, N, Kyiphyu, T, Oo, S, Win, S, Zar, H, Ghimire, R, Neupane, M, Glaudemans, A, Slart, R, Verschure, D, Allen, B, Edmond, J, Mckenzie, C, Tie, S, Van Pelt, N, Worthington, K, Young, C, Soli, I, Kana, S, Onubogu, U, Sani, M, Braten, A, Jorgensen, A, Vassbotn, H, Al Dhuhli, H, Jawa, Z, Tag, N, Fatima, S, Imran, M, Younis, M, Saadullah, M, Malo, Y, Lenturut-Katal, D, Castillo, M, Ortellado, J, Akhter, A, Cader, F, Hussain, R, Khan, S, Mandal, T, Nasreen, F, An, Y, Cao, D, Gong, L, Hou, Y, Jia, C, Li, T, Li, C, Liu, H, Liu, W, Liu, J, Ng, M, Shi, H, Tang, C, Wang, X, Wang, Z, Wang, Y, Wu, J, Yi, Y, Yuan, L, Zhang, T, Zhang, L, Chavez, E, Cruz, C, Llontop, C, Morales, R, Abrihan, P, Bustos-Barroso, A, Duldulao-Ogbac, M, Eduarte, C, Obaldo, J, Quinon, A, San Juan, B, San Juan, C, Sauler-Gomez, M, Uy, M, Kostkiewicz, M, Kunikowska, J, Teresinska, A, Urbanik, T, Bettencourt, N, Fontes-Carvalho, R, Gavina, C, Goncalves, L, Macedo, F, Moreno, N, Sousa, C, Timoteo, A, Vidigal, M, Al Heidous, M, Ramanathan, S, Arnous, S, Aytani, S, Byrne, A, Gleeson, T, Kerins, D, O'Brien, J, Bang, J, Bom, H, Cheon, M, Cheon, G, Cho, S, Hong, C, Jeong, Y, Kang, W, Kang, Y, Kim, J, Oh, S, So, Y, Song, H, Won, K, Yoo, S, Mitevska, I, Vavlukis, M, Salobir, B, Stalc, M, Benedek, T, Pop, M, Stan, C, Dariy, O, Gagarina, N, Itskovich, I, Karalkin, A, Kokov, A, Marina, G, Migunova, E, Pospelov, V, Ryzhkova, D, Sayfullina, G, Sergienko, V, Shurupova, I, Vakhromeeva, M, Valiullina, N, Zavadovsky, K, Zhuravlev, K, Abazid, R, Al Garni, T, Alasnag, M, Aljizeeri, A, Amer, H, Amro, A, Hamdy, H, Smettei, O, Saranovic, D, Vlajkovic, M, Keng, F, See, J, Berecova, Z, Mistinova, J, Evbuomwan, O, Govender, N, Hack, J, Hadebe, B, Hlongwa, K, Kaplan, M, Lakhi, H, Milos, K, Modiselle, M, More, S, Muambadzi, N, Scholtz, L, Barreiro-Perez, M, Blanco, I, Broncano, J, Camarero, A, Casans-Tormo, I, De Haro, J, Flotats, A, Garcia, E, Mendiguchia, C, Jimenez-Heffernan, A, Leta, R, Diaz, J, Vega, L, Manovel-Sanchez, A, Monzonis, A, Patrut, B, Pubul, V, Perez, R, Zeidan, N, Nanayakkara, D, Suliman, A, Engblom, H, Murtadha, M, Ostenfeld, E, Simonsson, M, Alkadhi, H, Buechel, R, Burger, P, Grani, C, Kamani, C, Kawel-Bohm, N, Klaeser, B, Manka, R, Prior, J, Kaewchur, T, Khiewvan, B, Kositwattanarerk, A, Namwongprom, S, Thientunyakit, T, Sayman, H, Yuksel, M, Sebikali, M, Okello, E, Korol, P, Noverko, I, Satyr, M, 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K. A., Doucoure M., Reichmuth L., Samuel A., Dieng M. L., Naojee A. S., Hernandez E. A., Alducin Tellez C. R., Alexanderson-Rosas E., Barragan E., Cabada M., Calderon D., Carvajal-Juarez I., Esparza J., Gama-Moreno M. G., Quinto V. G., Gonzalez N. C., Herrera-Zarza M. C., Meave A., Medina Verdugo J. G., Melendez G., Morales Murguia R. H., Navarro Quiroz C. S., Ornelas M., Preciado-Anaya A., Preciado-Gutierrez O. U., Puente A., Salazar A. R., Rosales Uvera S. G., Rosales-Uvera S., Serna Macias J. A., Sierra-Galan L., Sierra-Galan L. M., Tirado Alderete J. C., Vallejo E., Faraggi M., Sereegotov E., Ben Rais N., Alaoui N. I., Kyiphyu T., Oo S. T., Win S. M., Zar H., Ghimire R., Neupane M., Glaudemans A., Slart R., Verschure D., Allen B., Edmond J., Mckenzie C., Tie S., Van Pelt N., Worthington K., Young C., Soli I. A., Kana S., Onubogu U., Sani M., Braten A. T., Jorgensen A., Vassbotn H. -E., Al Dhuhli H., Jawa Z., Tag N., Fatima S., Imran M. B., Younis M. N., Saadullah M., Malo Y. H., Lenturut-Katal D., Castillo M., Ortellado J., Akhter A., Cader F. A., Hussain R., Khan S. R., Mandal T., Nasreen F., An Y., Cao D., Gong L., Hou Y., Jia C., Li T., Li C., Liu H., Liu W., Liu J., Ng M. -Y., Shi H., Tang C., Wang X., Wang Z., Wang Y., Wu J., Yi Y., Yuan L., Zhang T., Zhang L., Chavez E., Cruz C., Llontop C., Morales R., Abrihan P., Bustos-Barroso A., Duldulao-Ogbac M., Eduarte C., Obaldo J., Quinon A., San Juan B., San Juan C. J., Sauler-Gomez M. R., Uy M., Kostkiewicz M., Kunikowska J., Teresinska A., Urbanik T., Bettencourt N., Fontes-Carvalho R., Gavina C., Goncalves L., Macedo F., Moreno N., Sousa C., Timoteo A. T., Vidigal M. J., Al Heidous M., Ramanathan S., Arnous S., Aytani S., Byrne A., Gleeson T., Kerins D., O'Brien J., Bang J. -I., Bom H., Cheon M., Cheon G. J., Cho S. -G., Hong C. M., Jeong Y. H., Kang W. J., Kang Y. -K., Kim J. -Y., Oh S. W., So Y., Song H. -C., Won K. S., Yoo S. W., Mitevska I., Vavlukis M., Salobir B. G., Stalc M., Benedek T., Pop M., Stan C., Ansheles A., Dariy O., Gagarina N., Itskovich I., Karalkin A., Kokov A., Marina G., Migunova E., Pospelov V., Ryzhkova D., Sayfullina G., Sergienko V., Shurupova I., Vakhromeeva M., Valiullina N., Zavadovsky K., Zhuravlev K., Abazid R., Al Garni T., Alasnag M., Aljizeeri A., Amer H., Amro A., Hamdy H., Smettei O., Saranovic D. S., Vlajkovic M., Keng F., See J., Berecova Z., Mistinova J. P., Evbuomwan O., Govender N., Hack J., Hadebe B., Hlongwa K., Kaplan M., Lakhi H., Milos K., Modiselle M., More S., Muambadzi N., Scholtz L., Barreiro-Perez M., Blanco I., Broncano J., Camarero A., Casans-Tormo I., De Haro J., Flotats A., Garcia E., Mendiguchia C. G., Jimenez-Heffernan A., Leta R., Diaz J. L., Vega L. L., Manovel-Sanchez A., Monzonis A. M., Patrut B., Pubul V., Perez R. R., Zeidan N., Nanayakkara D., Suliman A., Engblom H., Murtadha M., Ostenfeld E., Simonsson M., Alkadhi H., Buechel R. R., Burger P., Grani C., Kamani C., Kawel-Bohm N., Klaeser B., Manka R., Prior J., Kaewchur T., Khiewvan B., Kositwattanarerk A., Namwongprom S., Thientunyakit T., Sayman H. B., Yuksel M., Sebikali M. J., Okello E., Korol P., Noverko I., Satyr M., Ahmad T., Alfakih K., Andrade I., Buckingham S., Bularga A., Carpenter J. -P., Cole G., Cusack D., David S., Davis P., Fairbairn T., Ghosh A., Ramkumar P. G., Hamilton M., Haque F., Hudson B., Johnstone A., Karthikeyan V. J., Kay M., Khan M. A., Kitt J., Low C. S., Mcalindon E., Mccreavy D., Morrissey B., Motwani M., Na D., Nicol E., Patel D., Rodrigues J., Rofe C., Schofield R., Semple T., Sheikh A., Sinha A., Subedi D., Topping W., Tweed K., Underwood S. R., Weir-Mccall J., Zuhairy H., Abbasi T., Abohashem S., Abramson S., Al-Mallah M., Kumar M. A., Balmer-Swain M., Berman D., Bernheim A., Bhatti S., Biederman R., Bieging E., Bingham S., Bloom S., Blue S., Borges A., Branch K., Bravo P., Buddhe S., Budoff M., Bullock-Palmer R., Cahill M., Candela C., Cao J., Chatterjee S., Chatzizisis Y., Chaudhuri N. R., Cheezum M., Chelliah A., Chen T., Chen M., Chen L., Chokshi A., Chung J., Danciu S., DeSisto W., Dilorenzo M., Doukky R., Duvall W., Ferencik M., Foster C., Fuisz A., Gannon M., German D., Gerson M., Geske J., Hage F., Haider A., Haider S., Hamirani Y., Hassen K., Hendel R., Henkel J., Horgan S., Hyun M., Janardhanan R., Jerome S., Kalra D., Kassop D., Kinkhabwala M., Kinzfogl G., Koch B., Koweek L., Krepp J., Kwon Y., Layer J., Lesser J., Leung S., Lisske B., Magurany K., Markowitz J., Mccullough B., Moalemi A., Moffitt C., Montanez J., Moore W., Morayati S., Mossa-Basha M., Mrsic Z., Murthy V., Nagpal P., Nelson K., Nijjar P., O'Quinn R., Passen E., Patil P., Pursnani A., Quachang N., Rabbat M., Ranjan P., Lozano P. R., Schemmer M., Seifried R., Shah N., Shah A., Shanbhag S., Sharma G., Skotnicki R., Sobczak M., Soman P., Sorrell V., Srichai M., Streeter J., Strickland L., Suliman S., Tebyanian N., Thomas D., Thompson R., Uretsky S., Vallurupalli S., Vandyck-Acquah M., Verma V., Villines T., Weinstein J., Wolinsky D., Zareba K., Zgaljardic M., Beretta M., Ferrando R., Kapitan M., Mut F., Djuraev O., Rozikhodjaeva G., Vera L., Duc B. D., Nguyen X. C., and Hiep Nguyen P. M.

Abstract

Background: The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown. Objectives: The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide. Methods: The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Multivariable regression was used to determine factors associated with procedure volume recovery. Results: Surveys were submitted from 669 centers in 107 countries. Worldwide reduction in cardiac procedure volumes of 64% from March 2019 to April 2020 recovered by April 2021 in high- and upper middle-income countries (recovery rates of 108% and 99%) but remained depressed in lower middle- and low-income countries (46% and 30% recovery). Although stress testing was used 12% less frequently in 2021 than in 2019, coronary computed tomographic angiography was used 14% more, a trend also seen for other advanced cardiac imaging modalities (positron emission tomography and magnetic resonance; 22%-25% increases). Pandemic-related psychological stress was estimated to have affected nearly 40% of staff, impacting patient care at 78% of sites. In multivariable regression, only lower-income status and physicians’ psychological stress were significant in predicting recovery of cardiac testing. Conclusions: Cardiac diagnostic testing has yet to recover to prepandemic levels in lower-income countries. Worldwide, the decrease in standard stress testing is offset by greater use of advanced cardiac imaging modalities. Pandemic-related psychological stress among providers is widespread and associated with poor recovery of cardiac testing.

Published
2022

21. The Metabolic Stability of the Nicotinic Acetylcholine Receptor at the Neuromuscular Junction

Author

Isabel Martinez-Pena y Valenzuela and Mohammed Akaaboune

Subjects
AChR, metabolic stability, synaptic activity, denervation, endocytosis, recycling, Cytology, QH573-671
Abstract

The clustering and maintenance of nicotinic acetylcholine receptors (AChRs) at high density in the postsynaptic membrane is a hallmark of the mammalian neuromuscular junction (NMJ). The regulation of receptor density/turnover rate at synapses is one of the main thrusts of neurobiology because it plays an important role in synaptic development and synaptic plasticity. The state-of-the-art imaging revealed that AChRs are highly dynamic despite the overall structural stability of the NMJ over the lifetime of the animal. This review highlights the work on the metabolic stability of AChRs at developing and mature NMJs and discusses the role of synaptic activity and the regulatory signaling pathways involved in the dynamics of AChRs.

Published
2021
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23. Distinct roles of the dystrophin–glycoprotein complex: α-dystrobrevin and α-syntrophin in the maintenance of the postsynaptic apparatus of the neuromuscular synapse

Author

Isabel Martinez-Pena y Valenzuela, Po-Ju Chen, Joseph Barden, Olivia Kosloski, and Mohammed Akaaboune

Subjects
Calcium-Binding Proteins, Membrane Proteins, Muscle Proteins, General Medicine, Dystrophin, Mice, nervous system, Dystrophin-Associated Proteins, Synapses, Genetics, Animals, Receptors, Cholinergic, Original Article, Muscle, Skeletal, Molecular Biology, Genetics (clinical), Glycoproteins
Abstract

α-syntrophin (α-syn) and α-dystrobrevin (α-dbn), two components of the dystrophin–glycoprotein complex, are essential for the maturation and maintenance of the neuromuscular junction (NMJ) and mice deficient in either α-syn or α-dbn exhibit similar synaptic defects. However, the functional link between these two proteins and whether they exert distinct or redundant functions in the postsynaptic organization of the NMJ remain largely unknown. We generated and analyzed the synaptic phenotype of double heterozygote (α-dbn+/−, α-syn+/−), and double homozygote knockout (α-dbn−/−; α-syn−/−) mice and examined the ability of individual molecules to restore their defects in the synaptic phenotype. We showed that in double heterozygote mice, NMJs have normal synaptic phenotypes and no signs of muscular dystrophy. However, in double knockout mice (α-dbn−/−; α-syn−/−), the synaptic phenotype (the density, the turnover and the distribution of AChRs within synaptic branches) is more severely impaired than in single α-dbn−/− or α-syn−/− mutants. Furthermore, double mutant and single α-dbn−/− mutant mice showed more severe exercise-induced fatigue and more significant reductions in grip strength than single α-syn−/− mutant and wild-type. Finally, we showed that the overexpression of the transgene α-syn-GFP in muscles of double mutant restores primarily the abnormal extensions of membrane containing AChRs that extend beyond synaptic gutters and lack synaptic folds, whereas the overexpression of α-dbn essentially restores the abnormal dispersion of patchy AChR aggregates in the crests of synaptic folds. Altogether, these data suggest that α-syn and α-dbn act in parallel pathways and exert distinct functions on the postsynaptic structural organization of NMJs.

Published
2022
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37. A Communication Inequalities Approach to Disparities in Physical Activities: The Case of the VERB Campaign

Author

Macarena Pena-y-Lillo and Chul-joo Lee

Subjects
Male, Health (social science), Ethnic group, 050801 communication & media studies, Verb, Health Promotion, Intention, Library and Information Sciences, Social class, Developmental psychology, Social group, 03 medical and health sciences, 0508 media and communications, Ethnicity, Humans, Social inequality, Longitudinal Studies, Child, Exercise, Socioeconomic status, Minority Groups, 030505 public health, Communication, Racial Groups, 05 social sciences, Public Health, Environmental and Occupational Health, Health Status Disparities, Health equity, Health promotion, Health Communication, Social Class, Female, 0305 other medical science, Psychology
Abstract

This study focuses on the VERB campaign and explores whether the campaign effects differed across socioeconomic status and race/ethnicity groups. Using a three-wave longitudinal survey dataset, this study found that the effects of exposure to the VERB campaign on behaviors were mediated by descriptive norms, perceived behavioral control (PBC), and intentions. More importantly, the VERB campaign increased intentions of being physically active by affecting PBC and descriptive norms across all social groups. When the link between intentions and behavior was taken into consideration, however, disparities between high and low SES, and majority and minority racial/ethnic group children emerged. The implications of this study for research on health disparities and public health communication campaigns are discussed.

Published
2019
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38. PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice.

Author

Isabel Martinez-Pena y Valenzuela, Marcelo Pires-Oliveira, and Mohammed Akaaboune

Subjects
Medicine, Science
Abstract

The steady state of the acetylcholine receptor (AChR) density at the neuromuscular junction (NMJ) is critical for efficient and reliable synaptic transmission. However, little is known about signaling molecules involved in regulating the equilibrium between the removal and insertion of AChRs that establishes a stable postsynaptic receptor density over time. In this work, we tested the effect of activities of two serine/threonine kinases, PKC and PKA, on the removal rate of AChRs from and the re-insertion rate of internalized recycled AChRs into synaptic sites of innervated and denervated NMJs of living mice. Using an in vivo time-lapse imaging approach and various pharmacological agents, we showed that PKC and PKA activities have antagonistic effects on the removal and recycling of AChRs. Inhibition of PKC activity or activation of PKA largely prevents the removal of pre-existing AChRs and promotes the recycling of internalized AChRs into the postsynaptic membrane. In contrast, stimulation of PKC or inactivation of PKA significantly accelerates the removal of postsynaptic AChRs and depresses AChR recycling. These results indicate that a balance between PKA and PKC activities may be critical for the maintenance of the postsynaptic receptor density.

Published
2013
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39. A communication inequalities approach to disparities in fruit and vegetable consumption: Findings from a national survey with U.S. adults

Author

Chul-joo Lee and Macarena Pena-y-Lillo

Subjects
Consumption (economics), Adult, 030503 health policy & services, Communication, Psychological intervention, Health literacy, General Medicine, Feeding Behavior, Health Promotion, Diet, Social group, 03 medical and health sciences, 0302 clinical medicine, Socioeconomic Factors, Environmental health, Fruit, Vegetables, Survey data collection, Humans, 030212 general & internal medicine, 0305 other medical science, Psychology, Path analysis (statistics), Socioeconomic status, Social capital
Abstract

Objectives This study assessed whether socioeconomic disparities in fruit and vegetable consumption and its differences by social capital are accounted for by exposure to media information about fruits and vegetables and reflective integration of that information. Methods Online survey data were collected in July 2014 from 572 U.S. adults from a nationally representative online panel. Path analysis was employed to test our models. Results Education and social capital were positively associated with media exposure, which was in turn positively related to reflective integration and finally led to fruit and vegetable consumption. Education and income were positively associated with social capital. Conclusion Differences in fruit and vegetable consumption across social groups are at least partly explained by exposure to information about fruits and vegetables from the media, and by reflective integration of that information. Practice Implications Healthcare professionals and health educators should create health messages delivered via the media that are easy to understand with an appropriate level of health literacy. Also, health interventions that aim to build social capital may promote health media use and its reasoning processes, thereby reducing communication inequalities by SES as well as disparities in fruit and vegetable consumption.

Published
2020

40. Preoperative Body Mass Index < 45 Kg/m2 Predicts Clinical Success after Bariatric Surgery in Patients with Ventricular Assist Devices

Author

daSilva-deAbreu, A., primary, Alhafez, B., additional, Garikapati, K., additional, Curbelo-Pena, Y., additional, Wooldridge, J., additional, Desai, S., additional, Eiswirth, C., additional, Krim, S., additional, Patel, H., additional, Loro-Ferrer, J.F., additional, Lavie, C.J., additional, Ventura, H.O., additional, and Mandras, S.A., additional

Published
2021
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48. List of Contributors

Author

Laura Aymerich-Franch, Jeremy N. Bailenson, Nicola Brew-Sam, Rebecca K. Britt, Christopher Calabrese, Pamara F. Chang, Arul Chib, Mark Chignell, Emily M. Cramer, Géraldine Fauville, Jacob T. Fisher, Jameson L. Hayes, Heather J. Hether, Koinig Isabell, Jeong-woo Jang, Shaheen Kanthawala, Subuhi Khan, Kai Kuang, Chul-joo Lee, SongYi Lee, Benjamin J. Li, Tony Liao, Jessica Maddox, Alexis K. Marsh, Henry Moller, Swati Pandita, Jorge Peña, Macarena Pena-y-Lillo, Anna Carolina Muller Queiroz, Rabindra Ratan, Diehl Sandra, Stephanie K. Van Stee, Ningxin Wang, John A. Waterworth, René Weber, Andrea Stevenson Won, and Qinghua Yang

Published
2020
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49. Revisiting the social enhancement and social compensation hypotheses in the social media era

Author

Jeong-woo Jang, Macarena Pena-y-Lillo, Ningxin Wang, and Chul-joo Lee

Subjects
Discussion board, Social support, Social compensation, Extraversion and introversion, business.industry, Internet privacy, Message board, Social media, Instant messaging, InformationSystems_MISCELLANEOUS, Psychology, business
Abstract

This study explores the effects of socially oriented online activities on subjective well-being. Using data from a longitudinal survey of college students (N = 413), the study tested the effects that instant messaging (IM), checking or updating profiles on social networking sites (SNS), sharing photos or videos, accessing to and posting on Twitter, and posting messages on discussion or message boards may have on subjective well-being. We also examined the roles of extraversion and social support as moderators of these effects. We found that SNS use increased subjective well-being over time; however, IM use had positive effects on well-being only among respondents with higher levels of extraversion and social support. Twitter use decreased well-being only for those with lower social support. Posting messages on discussion boards decreased well-being, while sharing photos and videos had no effect.

Published
2020
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50. Global patient perspective on top challenges in lupus care and research participation.

Author

Werth V., Bloch L., Bruce I.N., Costenbader K., Dickerson B., Dorner T., Getz K., Kao A., Manzi S., Morand E.F., Raymond S., Rovin B.H., Schanberg L., Von Feldt J., Hanrahan L., Zook D., Tse K., Pena Y., Arntsen K., Bae S.C., Werth V., Bloch L., Bruce I.N., Costenbader K., Dickerson B., Dorner T., Getz K., Kao A., Manzi S., Morand E.F., Raymond S., Rovin B.H., Schanberg L., Von Feldt J., Hanrahan L., Zook D., Tse K., Pena Y., Arntsen K., and Bae S.C.

Abstract

Background: The Addressing Lupus Pillars for Health Advancement (ALPHA) Project is a global consensus initiative to identify, prioritize and address top barriers in lupus drug development, clinical care and access to care. The Lupus Foundation of America convenes ALPHA with Tufts Center for the Study of Drug Development and a Global Advisory Committee of lupus experts representing clinician-scientists, industry and patients. Objective(s): Collect global patient input to determine alignment with the lupus clinician-scientist community on prior published consensus of top lupus barriers. Method(s): A 23-question online Qualtrics survey was developed to identify challenges across lupus diagnosis, clinical care and research participation. The survey, available in English, Spanish, Korean and simplified Chinese, was fielded in November 2019 to people with lupus and caregivers of children <18 with lupus. SPSS 26 and SAS 9.4 were used for descriptive statistics and sub-analysis. Result(s): Analysis included only consented responses with >= 68% survey completion (n=3,447) received across 83 countries. 95% were female with a mean age of 45. Respondents reported being White (57%), Black or of African descent (14%), Hispanic or Latino (18%) and Asian (10%). 65% resided in the US while 35% resided in countries outside of the US. 97% were people with lupus while 3% were caregivers to children <18 with lupus. Highest ranked challenges were similar globally and across children and adults: medication side effects, lack of treatment options and high out-of-pocket costs. Managing side effects ranked significantly higher (p<.05) outside of the US (48%) compared to US (40%). 50% of caregivers reported managing side effects as the top challenge for children compared to 43% of adults (p<.05). Research participation was low (24%) and lower among children (16%). The top reason for not participating in a clinical trial was not being asked by their doctor. Conclusion(s): This global survey re

Published
2020

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