56 results on '"Pengpeng Jia"'
Search Results
2. Mechanism and Control of Asymmetric Floor Heave in the Gob-Side Coal Roadway under Mining Pressure in Extra-Thick Coal Seams
- Author
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Deqiu Wang, Yun Zheng, Fulian He, Jiayu Song, Jianlong Zhang, Yanhao Wu, Pengpeng Jia, Xiaohui Wang, Baoping Liu, Feifei Wang, Yajiang Zhang, and Kai Tao
- Subjects
mining pressures ,gob-side coal roadway ,asymmetric floor heave ,failure mechanism ,cooperative control ,Technology - Abstract
Due to their tense mining succession relationship, gob-side roadways may undergo significant deformation under multi-mining pressure. In this article, many methods, such as on-site research, a theoretical analysis, a numerical simulation and an industrial experiment, are used to research the mechanism of asymmetric floor heave in a gob-side coal roadway affected by mining pressure during the mining of extra-thick coal seams. Our main research is as follows: (1) By monitoring the floor deformation in the roadway on site, it is concluded that the roadway floor shows asymmetry, indicating that the floor displacement near the coal pillar side is relatively large. (2) Based on a lateral overburden structure model of the roadway, the calculation formulas of the horizontal vertical stress caused by the roadway excavation and the excavation of the upper working face are derived separately, and the vertical stress coupling curves on both sides of the roadway during the mining of the upper working face are obtained through a numerical simulation. It is concluded that the cause of the asymmetric floor heave in the roadway is an uneven distribution of vertical stress. (3) The numerical simulation shows a symmetrical distribution of the floor displacement curve during the roadway excavation with a max. displacement of 49.5 mm. The floor displacement curve during the mining of the upper working face is asymmetric with a max. displacement of 873 mm at a distance of 1 m from the central axis near the coal pillar side. The range of the plastic zone in the roadway gradually expands with the mining of the upper working face, and the maximum depth of floor failure is 5.5 m. (4) According to the cooperative control principle of “roof + two sides + floor”, an asymmetric floor heave joint control scheme of “floor leveling + anchor cable support + concrete hardening” is proposed. The floor deformation monitoring results indicate that the max. floor heave at the measurement point near the coal pillar in the roadway is 167 mm, and the floor heave is effectively controlled.
- Published
- 2023
- Full Text
- View/download PDF
3. Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer
- Author
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Ruizhuo Ouyang, Penghui Cao, Pengpeng Jia, Hui Wang, Tianyu Zong, Chenyu Dai, Jie Yuan, Yuhao Li, Dong Sun, Ning Guo, Yuqing Miao, and Shuang Zhou
- Subjects
Au@Bi2S3 NBs ,DOX ,CT ,Photothermal conversion ,Cancer treatment ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging, novel Au@Bi2S3 core shell nanobones (NBs) (Au@Bi2S3 NBs) with Au nanorods as cores were synthesized. The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal (PT) conversion efficiency, remarkable photoacoustic (PA) imaging and high computed tomography (CT) performance; these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging. Subsequently, poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs (Au@Bi2S3-PVP NBs) were successfully loaded with the anticancer drug doxorubicin (DOX), and a satisfactory pH sensitive release profile was achieved, thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells. Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy, including extremely low toxicity, good biocompatibility, high drug loading ability, precise tumor targeting and effective accumulation. Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy (PTT). As both a contrast enhancement probe and therapeutic agent, Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy.
- Published
- 2021
- Full Text
- View/download PDF
4. Effects of High-Canolol Phenolic Extracts on Fragrant Rapeseed Oil Quality and Flavor Compounds during Frying
- Author
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Lili Cao, Pengpeng Jia, Haotian Liu, Shengmei Kang, Shaotong Jiang, and Min Pang
- Subjects
canolol ,fragrant rapeseed oil ,frying process ,flavor compounds ,Chemical technology ,TP1-1185 - Abstract
Fragrant rapeseed oil (FRO) is a frying oil widely loved by consumers, but its quality deteriorates with increasing frying time. In this study, the effect of high-canolol phenolic extracts (HCP) on the physicochemical properties and flavor of FRO during frying was investigated. During frying, HCP significantly inhibited the increase in peroxide, acid, p-anisidine, and carbonyl values, as well as total polar compounds and degradation of unsaturated fatty acids. A total of 16 volatile flavor compounds that significantly contributed to the overall flavor of FRO were identified. HCP was effective in reducing the generation of off-flavors (hexanoic acid, nonanoic acid, etc.) and increased the level of pleasant deep-fried flavors (such as (E,E)-2,4-decadienal). Therefore, the application of HCP has a positive effect on protecting the quality and prolonging the usability of FRO.
- Published
- 2023
- Full Text
- View/download PDF
5. Trend Feature Consistency Guided Deep Learning Method for Minor Fault Diagnosis
- Author
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Pengpeng Jia, Chaoge Wang, Funa Zhou, and Xiong Hu
- Subjects
deep learning ,minor fault ,trend feature consistency ,fault orientation consistency ,small sample size ,Science ,Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Deep learning can be applied in the field of fault diagnosis without an accurate mechanism model. However, the accurate diagnosis of minor faults using deep learning is limited by the training sample size. In the case that only a small number of noise-polluted samples is available, it is crucial to design a new learning mechanism for the training of deep neural networks to make it more powerful in feature representation. The new learning mechanism for deep neural networks model is accomplished by designing a new loss function such that accurate feature representation driven by consistency of trend features and accurate fault classification driven by consistency of fault direction both can be secured. In such a way, a more robust and more reliable fault diagnosis model using deep neural networks can be established to effectively discriminate those faults with equal or similar membership values of fault classifiers, which is unavailable for traditional methods. Validation for gearbox fault diagnosis shows that 100 training samples polluted with strong noise are adequate for the proposed method to successfully train deep neural networks to achieve satisfactory fault diagnosis accuracy, while more than 1500 training samples are required for traditional methods to achieve comparative fault diagnosis accuracy.
- Published
- 2023
- Full Text
- View/download PDF
6. Novel Water-in-Oil Emulsions for Co-Loading Sialic Acid and Chitosan: Formulation, Characterization, and Stability Evaluation
- Author
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Min Pang, Donglei Zheng, Pengpeng Jia, and Lili Cao
- Subjects
water-in-oil (W/O) emulsion ,sialic acid ,stabilization ,Chemical technology ,TP1-1185 - Abstract
This study was designed to co-load sialic acid (SA) and chitosan in a water-in-oil (W/O) emulsion and investigated its characterization and stability. Emulsions were prepared using two different oils (olive oil and maize oil) and polyglycerol polyricinoleate (PGPR) alone or in combination with lecithin (LE) as emulsifiers. The results revealed that the aqueous phase of 5% (w/v) SA and 2% (w/v) chitosan could form a stable complex and make the aqueous phase into a transparent colloidal state. Increasing the concentration of PGPR and LE presented different effects on emulsion formation between olive oil-base and maize oil-base. Two stable W/O emulsions that were olive oil-based with 1.5% (w/v) PGPR+ 0.5% (w/v) LE and maize oil-based with 2% (w/v) PGPR+ 0% (w/v) LE were obtained. Initial droplet size distribution curves of the two stable emulsions displayed unimodal distribution, and the rheological curves displayed the characteristics of shear thinning and low static shear viscosity. Moreover, the storage stability showed that there was no significant change in droplet size distribution and Sauter mean diameter of the emulsions at room temperature (25 °C) for 30 days. These results indicated that the W/O emulsions could effectively co-load and protect sialic acid and chitosan and thus could be a novel method for increasing the stability of these water-soluble bioactive compounds.
- Published
- 2022
- Full Text
- View/download PDF
7. CuS Hybrid Hydrogel for Near-Infrared-Enhanced Infected Wound Healing: A Gelatin-Assisted Synthesis and Direct Incorporation Strategy
- Author
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Pengpeng Jia, Yu Zou, and Jiang Jiang
- Subjects
General Materials Science - Published
- 2023
- Full Text
- View/download PDF
8. Mechanism and Control of Asymmetric Floor Heave in the Gob-Side Coal Roadway under Mining Pressure in Extra-Thick Coal Seams
- Author
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Tao, Deqiu Wang, Yun Zheng, Fulian He, Jiayu Song, Jianlong Zhang, Yanhao Wu, Pengpeng Jia, Xiaohui Wang, Baoping Liu, Feifei Wang, Yajiang Zhang, and Kai
- Subjects
mining pressures ,gob-side coal roadway ,asymmetric floor heave ,failure mechanism ,cooperative control - Abstract
Due to their tense mining succession relationship, gob-side roadways may undergo significant deformation under multi-mining pressure. In this article, many methods, such as on-site research, a theoretical analysis, a numerical simulation and an industrial experiment, are used to research the mechanism of asymmetric floor heave in a gob-side coal roadway affected by mining pressure during the mining of extra-thick coal seams. Our main research is as follows: (1) By monitoring the floor deformation in the roadway on site, it is concluded that the roadway floor shows asymmetry, indicating that the floor displacement near the coal pillar side is relatively large. (2) Based on a lateral overburden structure model of the roadway, the calculation formulas of the horizontal vertical stress caused by the roadway excavation and the excavation of the upper working face are derived separately, and the vertical stress coupling curves on both sides of the roadway during the mining of the upper working face are obtained through a numerical simulation. It is concluded that the cause of the asymmetric floor heave in the roadway is an uneven distribution of vertical stress. (3) The numerical simulation shows a symmetrical distribution of the floor displacement curve during the roadway excavation with a max. displacement of 49.5 mm. The floor displacement curve during the mining of the upper working face is asymmetric with a max. displacement of 873 mm at a distance of 1 m from the central axis near the coal pillar side. The range of the plastic zone in the roadway gradually expands with the mining of the upper working face, and the maximum depth of floor failure is 5.5 m. (4) According to the cooperative control principle of “roof + two sides + floor”, an asymmetric floor heave joint control scheme of “floor leveling + anchor cable support + concrete hardening” is proposed. The floor deformation monitoring results indicate that the max. floor heave at the measurement point near the coal pillar in the roadway is 167 mm, and the floor heave is effectively controlled.
- Published
- 2023
- Full Text
- View/download PDF
9. A geometric neural solving method based on a diagram text information fusion analysis
- Author
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Bin Ma, Pengpeng Jian, Cong Pan, Yanli Wang, and Wei Ma
- Subjects
Geometry problem solving ,Multi-modal information ,Feature extraction ,Diagram parser ,Medicine ,Science - Abstract
Abstract The long-standing problem of geometric problem solving in artificial intelligence education has attracted widespread attention. It is necessary to combine geometry diagrams and text descriptions to form a logical representation. This involves combining the knowledge of mathematical theorems, generating a solution sequence, and executing to obtain the answer. However, deficiencies in the feature extraction of geometry diagrams and the fusion of diagram text information can lead to poor performance in solving geometry problems. To effectively extract geometry diagram features, this study proposes an improved diagram parser DenseNet, and enhances the semantic representation of cross-modal information by adding auxiliary tasks. A structural and semantic pre-training strategy was used to parse the text description to avoid different problem solving schemes due to subtle differences in the interpretation of text content. Information fusion was realized by connecting the two modal labels, and then the information was sent to the encoder for fusion. The geometric knowledge was generated under the guidance of multi-modal information, and these programs were executed to obtain the results. Additionally, the performance of the proposed geometric neural solution method on the PGPS9K dataset is improved by 1.3% on average. Compared with the Geometry3K dataset, the effectiveness was proven.
- Published
- 2024
- Full Text
- View/download PDF
10. Ball pen writing-without-ink: a truly simple and accessible method for sensitivity enhancement in lateral flow assays
- Author
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Zedong Li, Shuang Wu, Jingcheng Ji, Yuemeng Bai, Pengpeng Jia, Yan Gong, Shangsheng Feng, and Fei Li
- Subjects
General Chemical Engineering ,General Chemistry - Abstract
Lateral flow assays (LFAs), a popular point-of-care testing platform, have found widespread applications from laboratory to clinics. However, LFA-based testing is still subject to limited detection sensitivity, especially for classical gold nanoparticle-based LFAs. Inspired by traditional pen-based writing technologies, we developed a ball pen writing-without-ink method to amplify the detection signal of LFAs through controlling fluid flow rate. An enhancement of detection sensitivity by two times was obtained. Since the underlying mechanism of this method to improve detection sensitivity is to control the flow rate of the liquid on paper, it may be suitable for most paper-based platforms.
- Published
- 2022
- Full Text
- View/download PDF
11. Application and Prospect of Spatial Information Technology in Inland Waterway Resources Census
- Author
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Pengpeng Jia, Zhefei Jin, Honglin Feng, Qiong Yang, and Wenwu Yang
- Abstract
In recent years, the rapid development of GIS, remote sensing, big data and other spatial information technologies have provided a huge driving force for the information construction and development of many industries. As an important branch of transportation field, inland water transportation also has great development opportunities in information construction. Since the second National Inland Waterway Census, great changes have taken place in the current situation of China’s inland waterway. It is urgent to carry out a new round of National Inland Waterway Census and comprehensively find out the current situation of China’s inland waterway. This paper comprehensively discusses the current situation of the application of spatial information technology in the general census of resources in typical industries. This paper also summarizes the basic situation of Inland Waterway Census in China, and analyzes the key and difficult points of the application of spatial information technology in Waterway Census data acquisition, working base map compilation, application achievement display and so on. It initially puts forward the technical scheme of channel resources census based on information means and online system. Compared with the traditional offline census, the technical scheme proposed in this study has achieved a breakthrough in improving the efficiency of census and ensuring the quality of census results. The research can provide technical reserves and experience for the general survey of channel resources for the whole country and all the provinces.
- Published
- 2023
- Full Text
- View/download PDF
12. Evaporation-Induced Diffusion Acceleration in Liquid-Filled Porous Materials
- Author
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Feng Xu, Tian Jian Lu, Xiaocong He, Pengpeng Jia, Shanyouming Sun, Shangsheng Feng, and Xuefeng Wang
- Subjects
Molecular diffusion ,Work (thermodynamics) ,Materials science ,General Chemical Engineering ,Diffusion ,Flow (psychology) ,Evaporation ,General Chemistry ,Article ,Chemistry ,Diffusion process ,Flow velocity ,Chemical physics ,Porous medium ,QD1-999 - Abstract
Liquid-filled porous materials exist widely in nature and engineering fields, with the diffusion of substances in them playing an important role in system functions. Although surface evaporation is often inevitable in practical scenarios, the evaporation effects on diffusion behavior in liquid-filled porous materials have not been well explored yet. In this work, we performed noninvasive diffusion imaging experiments to observe the diffusion process of erioglaucine disodium salt dye in a liquid-filled nitrocellulose membrane under a wide range of relative humidities (RHs). We found that evaporation can significantly accelerate the diffusion rate and alter concentration distribution compared with the case without evaporation. We explained the accelerated diffusion phenomenon by the mechanism that evaporation would induce a weak flow in liquid-filled porous materials, which leads to convective diffusion, i.e., evaporation-induced flow and diffusion (EIFD). Based on the EIFD mechanism, we proposed a convective diffusion model to quantitatively predict the diffusion process in liquid-filled porous materials under evaporation and experimentally validated the model. Introducing the dimensionless Peclet (Pe) number to measure the relative contribution of the evaporation effect to pure molecular diffusion, we demonstrated that even at a high RH of 95%, where the evaporation effect is usually assumed negligible in common sense, the evaporation-induced diffusion still overwhelms the molecular diffusion. The flow velocity induced by evaporation in liquid-filled porous materials was found to be 0.4–5 μm/s, comparable to flow in many biological and biomedical systems. The present analysis may help to explain the driving mechanism of tissue perfusion and provide quantitative analysis or inspire new control methods of flow and material exchange in numerous cutting-edge technologies, such as paper-based diagnostics, hydrogel-based flexible electronics, evaporation-induced electricity generation, and seawater purification.
- Published
- 2021
13. Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer
- Author
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Dong Sun, Ruizhuo Ouyang, Tianyu Zong, Hui Wang, Ning Guo, Penghui Cao, Jie Yuan, Pengpeng Jia, Chenyu Dai, Shuang Zhou, Yuhao Li, and Yuqing Miao
- Subjects
Biocompatibility ,0206 medical engineering ,Biomedical Engineering ,02 engineering and technology ,Biomaterials ,In vivo ,lcsh:TA401-492 ,medicine ,Doxorubicin ,lcsh:QH301-705.5 ,Au@Bi2S3 NBs ,DOX ,Chemistry ,technology, industry, and agriculture ,food and beverages ,Photothermal therapy ,021001 nanoscience & nanotechnology ,medicine.disease ,Photothermal conversion ,020601 biomedical engineering ,lcsh:Biology (General) ,Cancer treatment ,embryonic structures ,Cancer cell ,lcsh:Materials of engineering and construction. Mechanics of materials ,Nanorod ,0210 nano-technology ,Drug carrier ,Liver cancer ,CT ,Biotechnology ,medicine.drug ,Biomedical engineering - Abstract
To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging, novel Au@Bi2S3 core shell nanobones (NBs) (Au@Bi2S3 NBs) with Au nanorods as cores were synthesized. The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal (PT) conversion efficiency, remarkable photoacoustic (PA) imaging and high computed tomography (CT) performance; these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging. Subsequently, poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs (Au@Bi2S3-PVP NBs) were successfully loaded with the anticancer drug doxorubicin (DOX), and a satisfactory pH sensitive release profile was achieved, thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells. Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy, including extremely low toxicity, good biocompatibility, high drug loading ability, precise tumor targeting and effective accumulation. Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy (PTT). As both a contrast enhancement probe and therapeutic agent, Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy.
- Published
- 2021
- Full Text
- View/download PDF
14. Performance improvement of lateral flow assay using heterogeneous nitrocellulose membrane with nonuniform pore size
- Author
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Pengpeng Jia, Zedong Li, Xuefeng Wang, Feng Xu, Minli You, and Shangsheng Feng
- Subjects
General Chemical Engineering ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics - Published
- 2023
- Full Text
- View/download PDF
15. Spatially modulated stiffness on hydrogels for soft and stretchable integrated electronics
- Author
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Xiaojin Guo, Huayuan Yang, Shaobao Liu, Fei Li, Feng Xu, Moxiao Li, Shangsheng Feng, Hao Liu, Tian Jian Lu, and Pengpeng Jia
- Subjects
Materials science ,Biocompatibility ,Process Chemistry and Technology ,Stretchable electronics ,technology, industry, and agriculture ,Stiffness ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Coupling (electronics) ,Mechanics of Materials ,Interfacing ,visual_art ,Self-healing hydrogels ,Electronic component ,medicine ,visual_art.visual_art_medium ,General Materials Science ,Electronics ,Electrical and Electronic Engineering ,medicine.symptom ,0210 nano-technology - Abstract
One major conundrum that impedes the development and application of emerging soft and stretchable electronics lies in the integration of electronic components with soft substrates for rational combination of various device functionalities into a single wearable state, since the rigid, nondeformable electronics tend to detach from the deformable substrate under mechanical loadings like stretch. Modulating the stiffness of soft materials in a spatially controllable manner provides a promising solution to this rigid–soft coupling challenge, by shielding the local strain of rigid components while maintaining the stretchable properties of the soft substrates. Hydrogels with superb biocompatibility and skin-like mechanical features are ideal candidates for interfacing the human body and electronic functionalities for cutting-edge wearable uses, where there exists a challenge of spatially modulating the stiffness of hydrogels to meet the application demands. Herein, we develop a facile and straightforward method to locally stiffen a hydrogel (with an increased Young's modulus of one order of magnitude) via an additional crosslinking strategy. The locally stiffened site undergoes minimal strain (down to 12%) and the untreated area remains stretchable under external deformations (100% strain), which presents excellent and tunable strain shielding capability to prevent detachment of the electronic components from the substrate under strain levels up to 150%. We further demonstrate a multifunctional health sensing device based on a component-integrated locally stiffened hydrogel and its satisfactory performance in monitoring temperature, UV exposure and EMG signals unveils its brilliant prospects for wearable healthcare applications.
- Published
- 2020
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16. The role of reactive oxygen species in tumor treatment
- Author
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Pengpeng Jia, Penghui Cao, Chenyu Dai, Ruizhuo Ouyang, Yuqing Miao, and Dong Sun
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chemistry.chemical_classification ,Tumor microenvironment ,Cell signaling ,Reactive oxygen species ,General Chemical Engineering ,Autophagy ,Cell ,02 engineering and technology ,General Chemistry ,Biology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,medicine.disease ,medicine.disease_cause ,01 natural sciences ,0104 chemical sciences ,Metastasis ,medicine.anatomical_structure ,chemistry ,Apoptosis ,medicine ,Cancer research ,0210 nano-technology ,Oxidative stress - Abstract
Reactive oxygen species (ROS) are by-products of aerobic metabolism and can also act as signaling molecules to participate in multiple regulation of biological and physiological processes. The occurrence, growth and metastasis of tumors, and even the apoptosis, necrosis and autophagy of tumor cells are all closely related to ROS. However, ROS levels in the body are usually maintained at a stable status. ROS produced by oxidative stress can cause damage to cell lipids, protein and DNA. In recent years, ROS have achieved satisfactory results on the treatment of tumors. Therefore, this review summarizes some research results of tumor treatments from the perspective of ROS in recent years, and analyzes how to achieve the mechanism of inhibition and treatment of tumors by ROS or how to affect the tumor microenvironment by influencing ROS. At the same time, the detection methods of ROS, problems encountered in the research process and solutions are also summarized. The purpose of this review is to provide a clearer understanding of the ROS role in tumor treatment, so that researchers might have more inspiration and thoughts for cancer prevention and treatment in the next stage.
- Published
- 2020
- Full Text
- View/download PDF
17. Synthetic biology-powered biosensors based on CRISPR/Cas mediated cascade signal amplification for precise RNA detection
- Author
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Chao Zhang, Penghui Zhang, Hui Ren, Pengpeng Jia, Jingcheng Ji, Lei Cao, Peiwei Yang, Yuxin Li, Jie Liu, Zedong Li, Minli You, Xiaoman Duan, Jie Hu, and Feng Xu
- Subjects
General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2022
- Full Text
- View/download PDF
18. Cascade targeting tumor mitochondria with CuS nanoparticles for enhanced photothermal therapy in the second near-infrared window
- Author
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Haiyan Wu, Jiang Jiang, Pengpeng Jia, and Yu Zou
- Subjects
biology ,Photothermal Therapy ,CD44 ,Biomedical Engineering ,Nanoparticle ,Mitochondrion ,Photothermal therapy ,Phototherapy ,Mitochondria ,chemistry.chemical_compound ,chemistry ,In vivo ,Heat generation ,Hyaluronic acid ,biology.protein ,Biophysics ,Nanoparticles ,General Materials Science ,Tumor growth ,Copper - Abstract
Photothermal therapy, assisted by local heat generation using photothermal nanoparticles (NPs), is an emerging strategy to treat tumors noninvasively. To improve treatment outcomes and to alleviate potential side effects on normal tissue cells, utilizing the optically transparent second near-infrared (NIR-II) window and actively targeting tumors are critical. Considering that mitochondria are heat sensitive and play an important role in the up-regulation of metabolic activity in tumor cells, herein we report a cascade targeting scheme that enables active photothermal ablation of tumor mitochondria. First, NIR-II absorbing CuS NPs were surface modified with the mitochondria targeting moiety (3-carboxypropyl) triphenylphosphonium bromide (TPP) and then shielded with CD44 targeting hyaluronic acid, which will only expose TPP upon reaching the tumor sites. This allowed over 90% CuS NP enrichment at tumor mitochondria, and as a result, significantly improved tumor cell photothermal ablation was observed at the cellular level. An in vivo study demonstrated enhanced tumor uptake and improved tumor growth suppression by using these cascade targeting CuS NPs as NIR-II photothermal agents.
- Published
- 2021
19. Cell-Free Synthetic Biosensors Based on CRISPR/Cas Mediated Cascade Signal Amplification for Precise RNA Detection
- Author
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Chao Zhang, Xiaoman Duan, Peiwei Yang, Minli You, Hui Ren, Ji Jingcheng, Zedong Li, Jie Hu, Feng Xu, Pengpeng Jia, Yuxin Li, Jie Liu, Penghui Zhang, and Lei Cao
- Subjects
Chemistry ,Cascade ,RNA ,CRISPR ,Cell free ,Biosensor ,Signal amplification ,Cell biology - Abstract
Synthetic biology has been harnessed to create new diagnostic technologies. However, most synthetic biosensors involve error-prone amplification steps and limitations of accuracy in RNA detection. Here, we report a cell-free synthetic biosensing platform, termed as SHARK (Synthetic Enzyme Shift RNA Signal Amplifier Related Cas13a Knockdown Reaction), to efficiently and accurately amplify RNA signal by leveraging the collateral cleavage of activated Cas13a to regulate cell-free enzyme synthesis. Based on cascade amplification and customized enzyme output, SHARK behaves a broad compatibility in different scenarios. Using a personal glucose meter, we detected 50 copies/μl SARS-CoV-2 on a SHARK-loaded paper. In addition, when combined with machine learning, SHARK can perform bio-computations and thus provide miRNA patterns for cancer diagnosis and staging. SHARK shows characteristics of precise recognition, cascade amplification and customizable signal outputting in one pot comparisons with established assays based on 64 clinical samples, presenting great potential in developing next-generation RNA detection technology.
- Published
- 2021
- Full Text
- View/download PDF
20. Quantifying and Adjusting Plasmon-Driven Nano-Localized Temperature Field around Gold Nanorods for Nucleic Acids Amplification
- Author
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Pengpeng Jia, Xiaocong He, Zedong Li, Zheyu Wang, Minli You, Shangsheng Feng, Bin Gao, Chunyan Yao, Lei Cao, Yulin Ren, Srikanth Singamaneni, and Feng Xu
- Subjects
Materials science ,Nanotubes ,Field (physics) ,Infrared Rays ,Temperature ,Nanotechnology ,General Chemistry ,DNA ,Polymerase Chain Reaction ,Nano ,Nucleic acid ,General Materials Science ,Nanorod ,Gold ,DNA Probes ,Plasmon - Abstract
Fast nucleic acid (NA) amplification has found widespread biomedical applications, where high thermocycling rate is the key. The plasmon-driven nano-localized thermocycling around the gold nanorods (AuNRs) is a promising alternative, as the significantly reduced reaction volume enables a rapid temperature response. However, quantifying and adjusting the nano-localized temperature field remains challenging for now. Herein, a simple method is developed to quantify and adjust the nano-localized temperature field around AuNRs by combining experimental measurement and numerical simulation. An indirect method to measure the surface temperature of AuNRs is first developed by utilizing the temperature-dependent stability of Authiol bond. Meanwhile, the relationship of AuNRs' surface temperature with the AuNRs concentration and laser intensity, is also studied. In combination with thermal diffusion simulation, the nano-localized temperature field under the laser irradiation is obtained. The results show that the restricted reaction volume (≈aL level) enables ultrafast thermocycling rate (10
- Published
- 2021
21. Bistratal Au@Bi
- Author
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Ruizhuo, Ouyang, Penghui, Cao, Pengpeng, Jia, Hui, Wang, Tianyu, Zong, Chenyu, Dai, Jie, Yuan, Yuhao, Li, Dong, Sun, Ning, Guo, Yuqing, Miao, and Shuang, Zhou
- Subjects
Au@Bi2S3 NBs ,DOX ,Cancer treatment ,embryonic structures ,technology, industry, and agriculture ,food and beverages ,Photothermal conversion ,Article ,CT - Abstract
To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging, novel Au@Bi2S3 core shell nanobones (NBs) (Au@Bi2S3 NBs) with Au nanorods as cores were synthesized. The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal (PT) conversion efficiency, remarkable photoacoustic (PA) imaging and high computed tomography (CT) performance; these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging. Subsequently, poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs (Au@Bi2S3-PVP NBs) were successfully loaded with the anticancer drug doxorubicin (DOX), and a satisfactory pH sensitive release profile was achieved, thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells. Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy, including extremely low toxicity, good biocompatibility, high drug loading ability, precise tumor targeting and effective accumulation. Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy (PTT). As both a contrast enhancement probe and therapeutic agent, Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy., Graphical abstract Image 1, Highlights • Novel Au@Bi2S3 core shell NBs were synthesized with ultrahigh photothermal conversion efficiency (η=68.1%). • The Au@Bi2S3-PVP NBs can serve as a multimodal imaging agent for PT/PA/CT imaging. • The Au@Bi2S3-PVP NBs can act as nanocarrier for anticancer drug DOX in a pH sensitive DOX release profile. • This work reports outstanding NIR-triggered trimodal PT/PA/CT imaging-guided chemo/PT synergistic therapy of liver cancer.
- Published
- 2020
22. Numerical simulation of exhaust reforming characteristics in catalytic fixed-bed reactors for a natural gas engine
- Author
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Shangsheng Feng, Gesheng Li, Pengpeng Jia, Junjie Liang, Long Yanxiang, and Zunhua Zhang
- Subjects
Materials science ,Hydrogen ,General Chemical Engineering ,chemistry.chemical_element ,02 engineering and technology ,complex mixtures ,Industrial and Manufacturing Engineering ,Methane ,Water-gas shift reaction ,Catalysis ,Steam reforming ,chemistry.chemical_compound ,Natural gas ,0502 economics and business ,050207 economics ,health care economics and organizations ,Hydrogen production ,business.industry ,Applied Mathematics ,05 social sciences ,General Chemistry ,021001 nanoscience & nanotechnology ,chemistry ,Chemical engineering ,0210 nano-technology ,business ,Space velocity - Abstract
Coupled with detailed catalytic reaction mechanism, the exhaust reforming process in a fixed bed reactor was simulated using a porous media model to investigate the reforming characteristics under different initial conditions. The effects of gas hourly space velocity (GHSV), feed component, steam addition and wall temperature on the methane conversion rate, hydrogen yield and other characteristic parameters were analyzed. The simulation results show that the oxygen is consumed rapidly when the reforming gas enters the reaction zone and the steam reforming plays a dominant role in the latter part. The exhaust reforming process mainly involves oxidation reaction, steam reforming reaction and water gas shift reaction. The methane conversion and hydrogen production decrease with the rise of GHSV, while the molar ratio of H2 to CO first increases and then decreases and reaches its peak value when GHSV ranges from 30,000 h−1 to 35,000 h−1. As the ratio of methane to exhaust increases, a higher molar fraction of hydrogen at the outlet can be achieved owing to a bigger proportion of partial reforming reaction of methane, and methane conversion rate decreases. It also suggests that a modest steam addition is preferable for both the reforming performance and the life span of the fixed bed.
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- 2018
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23. Numerical study of exhaust reforming characteristics on hydrogen production for a marine engine fueled with LNG
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Zunhua Zhang, Junjie Liang, Geyu Zhong, Gesheng Li, and Pengpeng Jia
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Materials science ,Waste management ,Carbon dioxide reforming ,Methane reformer ,Hydrogen ,business.industry ,020209 energy ,education ,05 social sciences ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,Combustion ,Industrial and Manufacturing Engineering ,Methane ,Steam reforming ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,0502 economics and business ,0202 electrical engineering, electronic engineering, information engineering ,Exhaust gas recirculation ,050207 economics ,business ,Hydrogen production - Abstract
When the engine exhaust heat is used for catalytically reforming the mixtures of natural gas and partial exhaust to produce the on-board hydrogen, the hydrogen-rich combustion can be achieved to improve the combustion performance of the natural gas engine. In this work, according to the Exhaust Gas Recirculation (EGR) system of a LNG-fueled engine, an exhaust reforming reaction tube of the reformer with interior coated Ni-based catalyst was modeled with full computational fluid dynamics (CFD) combined with detailed chemical reaction mechanisms to study the reforming characteristics when the EGR ratio ranges from 2.5% to 10% and the molar ratio of water to carbon ranges from 1.0 to 3.5. The simulation results present species formation characteristics in the reforming reactions which involve only steam reforming reaction and partial reforming reaction. Higher mass ratio of water to fuel (W/F) is advantageous for the methane reforming reaction, more hydrogen yield and the inhibition of the coke formation, while higher EGR ratio promotes the conversion of methane and carbon monoxide production. The simulation result also gets a high molar ratio of hydrogen to carbon monoxide ratio for the presence of excess water content. In the given conditions, a more preferable reaction process can be achieved when EGR rate is equal to 5% and W/F gets the value of 3.5.
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- 2017
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24. Impacts of temperature and precipitation on the spatiotemporal distribution of water resources in Chinese mega cities: the case of Beijing
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Dafang Zhuang, Pengpeng Jia, and Yong Wang
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Hydrology ,Atmospheric Science ,Global and Planetary Change ,Resource (biology) ,Land use ,0208 environmental biotechnology ,02 engineering and technology ,Land cover ,Management, Monitoring, Policy and Law ,020801 environmental engineering ,Water resources ,Beijing ,Urbanization ,Environmental science ,Precipitation ,Urban heat island ,Water resource management ,Water Science and Technology - Abstract
Water shortages in China have hindered development of mega cities, especially Beijing. Assessing the impact of temperature and precipitation on water resources is important. This study analyzed spatiotemporal variations and impacts of temperature and precipitation on water resources in Beijing from 1956 to 2013, using statistical and spatial analysis. The results showed the following. (1) Temperature and precipitation affect water resources variously from region to region; their correlation in mountains is lower than in other areas. Precipitation redistribution caused by terrain reduces water resources. (2) The inter-annual variabilities of precipitation, temperature and water resources are different among five water resource divisions. Because of ‘rain-slope’, Beisanhe's precipitation is larger than others; Yongdinghe's precipitation is less than others due to ‘rain-shadow’; suffering from urban heat island effect, Beisihe and Daqinghe-plain's temperature is higher than others; Beisanhe and Beisihe's water resources are greater than others due to area differences. (3) Water resources are positively correlated with precipitation and negatively with temperature. (4) In recent years, precipitation and water resources decreased and temperature rose. Population growth, land use/land cover change, urbanization and pollution affected precipitation, temperature and water resources. Imported water cannot completely solve water shortages. With increasing water demand, precipitation and temperature will significantly influence water resources in Beijing.
- Published
- 2017
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25. Review: recent advances and future development of metal complexes as anticancer agents
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Haizhou Chang, Pengpeng Jia, Tian Lei, Xiao Tong, Penghui Cao, Yuefeng Zhao, Ning Guo, Shuang Zhou, Xia Zhou, Ruizhuo Ouyang, and Yuqing Miao
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Aqueous medium ,010405 organic chemistry ,Chemistry ,Materials Chemistry ,Physical and Theoretical Chemistry ,Pharmacology ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,Clinical treatment ,0104 chemical sciences - Abstract
Since the initial discovery of applications of platinum complexes in the clinical treatment of many kinds of cancers, the efficiency of platinum complexes in inhibiting the proliferation of various types of tumors surprised researchers working on the development of anticancer drugs. Meanwhile, despite the potent clinical treatment patients get from platinum complexes, there are also disadvantages including limited solubility in aqueous media and side effects like ototoxicity, myelosuppression, nephrotoxicity, and poor selectivity toward healthy cells. For this reason, efforts have been made to search for novel solutions. Non-platinum complexes (like Fe, Pd, Ru, Cu, Bi, Zn, etc.) were found with potential anticancer activities. We here review the properties of five metal complexes as anticancer agents and make comparisons among them in biological features and cytotoxic activity. Seeking the interrelation between microstructure and mechanism of anticancer, we hope this review provides distinct insig...
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- 2017
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26. Excellent electrocatalytic performance of a Ni2+-loaded multiwalled carbon nanotube composite in glucose oxidation
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Yang Yang, Kai Feng, Yongfu Su, Fei Xiong, Yuqing Miao, Ying Chen, Yuefeng Zhao, Tianyu Zong, Shuang Zhou, Haizhou Chang, Ruizhuo Ouyang, and Pengpeng Jia
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Detection limit ,Nanotube ,Materials science ,Composite number ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Electrochemistry ,Electrocatalyst ,01 natural sciences ,0104 chemical sciences ,Adsorption ,Chemical engineering ,Inductively coupled plasma atomic emission spectroscopy ,Electrode ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology - Abstract
A new type of Ni2+-loaded MWCNT composite was prepared by mixing carboxylated multiwalled carbon nanotubes (MWCNTs) and Ni2+ ions and allowing them to interact electrostatically. The resulting composite was subsequently used as an electrocatalyst for glucose (Glu) oxidation. Compared with electrodes modified through the addition of free Ni2+ ions or MWCNTs, the Ni2+/MWCNT composite electrode showed greatly improved properties such as hydrophilicity. Investigations of the Ni2+/MWCNT composite electrode via inductively coupled plasma atomic emission spectroscopy and nitrogen adsorption–desorption isotherms verified that Ni2+ ions had been adsorbed onto the surfaces of the MWCNTs in the composite. As expected, a Ni2+/MWCNT composite-based sensor showed extraordinary electrocatalytic performance in Glu oxidation. In the concentration range 0–4.3 mM, a good linear relationship between the Glu added and the current generated was observed, with a correlation coefficient (R 2) of 0.9988. The detection limit and sensitivity were calculated to be 0.081 μM and 2285 μA mM−1 cm−2, respectively. Finally, the new method was successfully applied to determine the Glu in a human blood sample. Recoveries of >100%, indicative of high reliability, accuracy, and precision, were obtained.
- Published
- 2017
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27. Progesterone attenuates Aβ
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Zhigang, Wu, Hang, Wu, Shuang, Sun, Honghai, Wu, Wenjing, Shi, Jing, Song, Jianfang, Liu, Yunhao, Zhang, Fang, Bian, Pengpeng, Jia, and Yanning, Hou
- Subjects
Cerebral Cortex ,Neurons ,Proteomics ,Amyloid beta-Peptides ,Cell Survival ,Membrane Proteins ,Apoptosis ,Neuroprotection ,Rats ,Rats, Sprague-Dawley ,Gene Knockout Techniques ,Methionine ,Alzheimer Disease ,Tandem Mass Spectrometry ,Animals ,Humans ,Gene Silencing ,Enzyme Inhibitors ,Receptors, Progesterone ,Chromatography, High Pressure Liquid ,Progesterone ,GRB2 Adaptor Protein ,Signal Transduction - Abstract
Progesterone receptor membrane component 1 (PGRMC1) has been reported to mediate the neuroprotective effect of progesterone, but the exact mechanism has not been elucidated. Therefore, the purpose of this study was to investigate the signalling pathway downstream of PGRMC1 in progesterone-induced neuroprotection. Recognition of the mechanism of progesterone opens novel perspectives for the treatment of diseases of the nervous system.The PGRMC1 protein level was knocked down in rat primary cortical neurons, and AβThe neuroprotective effect of progesterone was significantly attenuated with PGRMC1 silencing. The expression of many proteins in the Ras signalling pathway was significantly changed in response to PGRMC1 silencing. FTI-277 inhibited progesterone-induced neuroprotection. Progesterone increased the expression of total Ras and Grb2.These findings provide new perspectives for understanding the mechanism of and role of PGRMC1 in progesterone-induced neuroprotection. The Ras signalling pathway is the signalling pathway downstream of PGRMC1 in the mediation of progesterone-induced neuroprotection.
- Published
- 2019
28. Front Cover: Quantifying and Adjusting Plasmon‐Driven Nano‐Localized Temperature Field around Gold Nanorods for Nucleic Acids Amplification (Small Methods 5/2021)
- Author
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Yulin Ren, Xiaocong He, Pengpeng Jia, Chunyan Yao, Minli You, Srikanth Singamaneni, Feng Xu, Zedong Li, Shangsheng Feng, Zheyu Wang, Bin Gao, and Lei Cao
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Materials science ,Front cover ,Field (physics) ,business.industry ,Nano ,Nucleic acid ,Optoelectronics ,General Materials Science ,Nanorod ,General Chemistry ,business ,Plasmon - Published
- 2021
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29. Potential anti-cancer activity of a novel Bi(III) containing thiosemicarbazone derivative
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Kai Feng, Ruizhuo Ouyang, Ning Guo, Yaoqin Yang, Shuang Zhou, Yuqing Miao, Haizhou Chang, Penghui Cao, Yang Yang, Xiao Tong, Huihong Tao, Pengpeng Jia, and Tianyu Zong
- Subjects
Cisplatin ,010405 organic chemistry ,Stereochemistry ,Chemistry ,Cancer ,010402 general chemistry ,medicine.disease ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,medicine.anatomical_structure ,Apoptosis ,Toxicity ,Materials Chemistry ,medicine ,Cancer research ,Physical and Theoretical Chemistry ,Fibroblast ,Cytotoxicity ,Lung cancer ,Semicarbazone ,medicine.drug - Abstract
By mixing 5-bromo-2-furaldehyde, phenylthiosemicarbazide and Bi(CH3COO)3, a new amorphous bismuth-containing complex, BiL2Cl3, was synthesized under aqueous conditions via a one-pot method and characterized with some analytical techniques, where L was produced by dehydration between 5-bromo-2-furaldehyde, phenylthiosemicarbazide. The obtained complex effectively inhibited the proliferation and migration of A549 and H460 lung cancer cells, induced cell apoptosis and displayed fairly low cytotoxicity to normal human lung fibroblast (HLF). Compared with cisplatin, BiL2Cl3 displayed better anti-cancer activity against tumor cells and lower toxicity to normal cell. Therefore, BiL2Cl3 with potent anti-cancer activity may be a viable drug candidate in anti-cancer therapies.
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- 2016
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30. Anomaly based multi-stage attack detection method.
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Wei Ma, Yunyun Hou, Mingyu Jin, and Pengpeng Jian
- Subjects
Medicine ,Science - Abstract
Multi-stage attacks are one of the most critical security threats in the current cyberspace. To accurately identify multi-stage attacks, this paper proposes an anomaly-based multi-stage attack detection method. It constructs a Multi-Stage Profile (MSP) by modeling the stable system's normal state to detect attack behaviors. Initially, the method employs Doc2Vec to vectorize alert messages generated by the intrusion detection systems (IDS), extracting profound inter-message correlations. Subsequently, Hidden Markov Models (HMM) are employed to model the normal system state, constructing an MSP, with relevant HMM parameters dynamically acquired via clustering algorithms. Finally, the detection of attacks is achieved by determining the anomaly threshold through the generation probability (GP). To evaluate the performance of the proposed method, experiments were conducted using three public datasets and compared with three advanced multi-stage attack detection methods. The experimental results demonstrate that our method achieves an accuracy of over 99% and precision of 100% in multi-stage attack detection. This confirms the effectiveness of our method in adapting to different attack scenarios and ultimately completing attack detection.
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- 2024
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31. Traffic control optimization strategy based on license plate recognition data
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Ruimin Li, Shi Wang, Pengpeng Jiao, and Shichao Lin
- Subjects
Traffic control ,Model predictive control ,Closed-loop control ,License plate recognition data ,Transportation engineering ,TA1001-1280 - Abstract
Traffic signal control is essential to the efficiency of the road network's operation. In recent years, more and more detailed detection data provide potential data support for traffic signal control, such as license plate recognition (LPR) data. This study aims to develop a traffic signal control optimization method based on model predictive control (MPC) and LPR data. The proposed framework of a closed-loop control system is described in detail. First, the control objectives and queue prediction model for signalized intersection are determined. Then, online optimization and feedback compensation are discussed and implemented. Calculations of the arrival rate at the downstream are based on the LPR data detected at the upstream intersection, and dynamic optimization method of the offset is proposed for a coordinated control. The model is validated using the LPR data of two consecutive intersections with a traffic simulation platform. Results demonstrate that the model can restrain extreme long queuing, improve intersection capacity, and reduce intersection average delay. The developed model promotes the system operating efficiency and shows the general advantage of real-time optimization, feedback, and control. The proposed framework can be potentially applied by local traffic management centers to improve the quality of traffic signal control.
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- 2023
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32. ADSORPTIVE STRIPPING DETERMINATION OF TRACE NICKEL USING BISMUTH MODIFIED MESOPOROUS CARBON COMPOSITE ELECTRODE
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Kai Feng, Haizhou Chang, Yuqing Miao, Ruizhuo Ouyang, Xia Zhou, Tianyu Zong, Pengpeng Jia, Ning Guo, Yuefeng Zhao, Penghui Cao, Shuang Zhou, Yongfu Su, and Tian Lei
- Subjects
Detection limit ,Materials science ,Stripping (chemistry) ,Analytical chemistry ,chemistry.chemical_element ,02 engineering and technology ,Surfaces and Interfaces ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,Bismuth ,chemistry.chemical_compound ,Nickel ,Dimethylglyoxime ,chemistry ,Electrode ,Adsorptive stripping voltammetry ,Materials Chemistry ,0210 nano-technology - Abstract
Novel bismuth nanoparticle-modified mesoporous carbon (MPC) was successfully prepared on a glassy carbon electrode (Bi@MPC/GCE) for the adsorptive stripping voltammetric determination of nickel by complexing with dimethylglyoxime (DMG). The presence of MPC obviously improved the properties of Bi particles like the electron transfer ability, particle size and hydrophicility, important parameters to achieve preferable analytical performances of Bi@MPC/GCE toward Ni(II). The best electrochemical behaviors of Bi@MPC/GCE was obtained for the stripping determination of Ni(II), compared with electrodes individually modified with Bi and MPC. The synergic effect between metallic Bi and ordered MPC (forming a 3D array like Bi microelectrodes) made major contribution to such improved electrochemical properties of Bi@MPC/GCE for Ni(II) sensing. The good linear analytical curve was achieved in a Ni(II) concentration range from 0.1[Formula: see text][Formula: see text]M to 5.0[Formula: see text][Formula: see text]M with a correlation coefficient of 0.9995. The detection limit and sensitivity were calculated to be 1.2[Formula: see text]nM ([Formula: see text]) and 1410[Formula: see text][Formula: see text]A[Formula: see text]mM[Formula: see text][Formula: see text]cm[Formula: see text], respectively. The new method was successfully applied to Ni(II) determination in soybean samples with recoveries higher than 99% and proved to be a simple, efficient alternative for Ni(II) monitoring in real samples.
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- 2017
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33. Analyzing the Risk Factors of Traffic Accident Severity Using a Combination of Random Forest and Association Rules
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Jianyu Wang, Shuo Ma, Pengpeng Jiao, Lanxin Ji, Xu Sun, and Huapu Lu
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crash severity ,random forest ,shapley additive explanation ,Apriori ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
This study explores risk factors influencing the at-fault party in traffic accidents and analyzes their impact on traffic accident severity. Based on the traffic accident data of Shenyang City, Liaoning Province, China, from 2018 to 2020, 19 attribute variables including road attributes, time attributes, environmental attributes, and characteristics of the at-fault parties with either full responsibility, primary responsibility, or equal responsibility of the traffic accidents were extracted and analyzed in conjunction with the built environment attributes, such as road network density and POI (points of interest) density at the sites of traffic accidents. Using the RF-SHAP method to determine the relative importance of risk factors influencing the severity of traffic accidents with either motor vehicles or vulnerable groups at-fault, the top ten risk factors influencing the severity of traffic accidents with vulnerable road users as the at-fault parties are: functional zone, density of shopping POI, density of services POI, cause of accident, travel mode, collision type, season, road type, age of driver, and physical isolation. Travel mode, season, and road speed limit are more important risk factors for traffic accidents, with motor vehicle drivers as the at-fault parties. The density of service POI and cause of the accident are less critical for traffic accidents with motor vehicle drivers than traffic accidents with vulnerable road users who are at-fault. Subsequently, the Apriori algorithm based on association rules is used to analyze the important causal factors of traffic accidents, so as to explore the influence mechanism of multiple causal factors and their implied strong association rules. Our results show that most combined factors are associated with the matched Service and Shopping POI features. This study provides valuable information on the perceived risk of fatal accidents and highlights the built environment’s significant influence on fatal traffic accidents. Management strategies targeting the most typical combinations of accident risk factors are proposed for preventing fatalities and injuries in serious traffic accidents.
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- 2023
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34. Identification of three predictors of gastric cancer progression and prognosis
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Kai Huang, Shuhua Chen, Rongzhang Xie, Pengpeng Jiang, Changjun Yu, Jinmei Fang, Xingcun Liu, and Fazhi Yu
- Subjects
gastric cancer ,potential predictors ,TCGA ,GEO ,Biology (General) ,QH301-705.5 - Abstract
Abnormal gene expression is an established cause of gastric cancer (GC) initiation and progression. In this study, we aimed to identify several key genes that could be used to effectively predict progression and prognosis in patients with GC. The Cancer Genome Atlas and the Gene Expression Omnibus database were used to identify candidate genes. Fourteen genes were found to associate highly with progress, metastasis, and survival of GC. Five of these genes were overexpressed in tumor tissue compared to adjacent normal tissue. This was confirmed by reverse transcription‐polymerase chain reaction and western blotting for myosin‐Va (MYO5A), phospholipid transfer protein (PLTP), and tripeptidyl peptidase 1 (TPP1), while the CCK8 assay was used to show that these three genes promote GC cell proliferation. In summary, we demonstrate that MYO5A, PLTP, and TPP1 expression may be suitable markers for the progression and prognosis of GC.
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- 2020
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35. Cascaded Progressive Generative Adversarial Networks for Reconstructing Three-Dimensional Grayscale Core Images From a Single Two-Dimensional Image
- Author
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Yang Li, Pengpeng Jian, and Guanghui Han
- Subjects
porous media ,3D microstructure reconstruction ,deep learning ,cascaded progressive generative adversarial network (CPGAN) ,super-dimension (SD) ,Physics ,QC1-999 - Abstract
It is very challenging to accurately understand and characterize the internal structure of three-dimensional (3D) rock masses using geological monitoring and conventional laboratory measures. One important method for obtaining 3D core images involves reconstructing their 3D structure from two-dimensional (2D) core images. However, traditional 2D–3D reconstruction methods are mostly designed for binary core images, rather than grayscale images. Furthermore, the reconstruction structure cannot reflect the gray level distribution of the core. Here, by combining the dimension promotion theory in super-dimension (SD) reconstruction and framework of deep learning, we propose a novel convolutional neural network framework, the cascaded progressive generative adversarial network (CPGAN), to reconstruct 3D grayscale core images. Within this network, we propose a loss function based on the gray level distribution and pattern distribution to maintain the texture information of the reconstructed structure. Simultaneously, by adopting SD dimension promotion theory, we set the input and output of every single node of the CPGAN network to be deep gray-padding structures of equivalent size. Through the cascade of every single node network, we thus ensured continuity and variability between the reconstruction layers. In addition, we used 3D convolution to determine the spatial characteristics of the core. The reconstructed 3D results showed that the gray level information in the 2D image were accurately reflected in the 3D space. This proposed method can help us to understand and analyze various parameter characteristics in cores.
- Published
- 2022
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36. Corrigendum to 'Optimization Model of Traffic Sensor Layout considering Traffic Big Data'
- Author
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Xu Sun, Zixiu Bai, Kun Lin, Pengpeng Jiao, and HuaPu Lu
- Subjects
Transportation engineering ,TA1001-1280 ,Transportation and communications ,HE1-9990 - Published
- 2022
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37. Does Policy Matter in Carsharing Traveling? Evolution Game Model-Based Carsharing and Private Car Study
- Author
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Wei Luo, Shi Qiu, Pengpeng Jiao, Liya Yao, and Yi Wang
- Subjects
Transportation engineering ,TA1001-1280 ,Transportation and communications ,HE1-9990 - Abstract
As an alternative trip mode to the private car, carsharing mode first emerged in Europe in the 1940s. Although it possesses many merits such as convenience, affordability, and comfort, its development is far slower than the private car in recent years. Identifying the factors affecting the users’ choice between carsharing and private car is becoming very important. This paper proposes an evolution game model to explore the competitive choice process between carsharing and private car under different government policies. First, an evolution game model with incomplete information is developed to analyze the travel choice of carsharing over private car. The influences of government policy are taken into consideration. Then, the evolutionary stable strategy solution of the model is derived from replicator dynamics, and a discussion about the stable condition is presented. Finally, a case study is conducted to validate the proposed model. This study provides a rationale for agencies to improve the current carsharing choice rate between carsharing and private car.
- Published
- 2022
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38. Improvement Strategy at Pedestrian Bottleneck in Subway Stations
- Author
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Wei Luo, Yi Wang, Pengpeng Jiao, and Zehao Wang
- Subjects
Mathematics ,QA1-939 - Abstract
The bottleneck normally refers to a narrowed region that decreases the flow, which is the key limiting factor in the pedestrian flow in the subway station. Due to the confined space, pedestrians are frequently forced to gather together at bottlenecks, which could not only limit the pedestrians’ efficiency and comfort but also cause serious crowd catastrophes such as stampedes. Optimization techniques for crowd congestion in subway stations should be investigated. This study proposed and demonstrated a set of optimization methods using conduction field experiments. The effects of passing time, traffic efficiency, speed, and density were explored using different design models. Results showed that optimization methods such as the design with a 45° funnel, broken guardrail, concaves, and column on the left had significant optimal effects. The optimization methods used in this study would help to implement bottlenecks in subway stations and provide design suggestions to subway designers.
- Published
- 2022
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39. On the origin of the shift in color in white organic light-emitting diodes
- Author
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Min Kong, Zhen Yu, Wei Huang, Qiang Wu, Xiaofei Zhao, Pengpeng Jia, and Shufen Chen
- Subjects
Brightness ,White emission ,Materials science ,business.industry ,General Chemistry ,Backlight ,Electroluminescence ,Rendering (computer graphics) ,Materials Chemistry ,OLED ,Optoelectronics ,Chromaticity ,business ,Diode - Abstract
White organic light-emitting diodes (WOLEDs) have attracted more and more attention in recent years because of their potential applications on flat-panel displays, solid-state lighting, and liquid-crystal display backlighting sources. With the goal towards practical applications, it requires WOLEDs possess not only high brightness and large electroluminescent (EL) efficiency, but also excellent stability. Here, good device stability includes two aspects, these are long operation lifetime and good color stability over a wide EL range. In this review, we explored all possible factors rendering a shift in color in both single- and multiple-emitting layer WOLEDs and summarized some typical design strategies for preventing shift in color of white emission. We hope the present paper can provide valuable clues to academic researchers and industrial designers in developing highly efficient WOLEDs with extremely stable chromaticity.
- Published
- 2013
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40. Exploring Passengers’ Dependency Variety on Stations’ Functions in Urban Subway
- Author
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Xia Zhao, Pengpeng Jiao, Yong Zhang, and Chenjing Zhou
- Subjects
Transportation engineering ,TA1001-1280 ,Transportation and communications ,HE1-9990 - Abstract
Urban subway is taken by people in different frequencies, thus leading them to present different dependency varieties on this mode. Yet, how those passengers who possess low dependency on urban subway travel is less investigated. Under this background, we propose a framework to uncover passengers’ dependency variety on stations’ functions in urban subway. To begin with, nine features regarding travel frequency and time are extracted from 100 million transaction records generated by 11.45 million passengers in a month. Thus, their travel dependency on urban subway is quantified. These features are clustered into 5 distinct levels via the k-means algorithm, before an inference of subway stations’ functions from 236,040 POI data sources via the LDA approach. In this way, passengers’ travel purposes can be identified. How passengers with different dependency levels behave in subway stations in space and time is further explored in a visualization way. The intuitive experimental results, validated by priori user experiences and land-use plan of Beijing, show that among the 5 levels of dependency varieties, passengers in the first two groups present a relatively strong dependency on urban subway. Meanwhile, passengers in the rest three groups possess a low dependency on urban subway and display extreme travel patterns in time and frequency, greatly increasing management difficulties for transit operators. Findings in this research help distinguish passengers with low levels of subway dependency and grasp how those passengers without striking dependency travel by subway and what for so that practitioners can conduct an accurate risk assessment on them.
- Published
- 2021
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- View/download PDF
41. Spatio-Temporal Segmented Traffic Flow Prediction with ANPRS Data Based on Improved XGBoost
- Author
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Bo Sun, Tuo Sun, and Pengpeng Jiao
- Subjects
Transportation engineering ,TA1001-1280 ,Transportation and communications ,HE1-9990 - Abstract
Traffic prediction is highly significant for intelligent traffic systems and traffic management. eXtreme Gradient Boosting (XGBoost), a scalable tree lifting algorithm, is proposed and improved to predict more high-resolution traffic state by utilizing origin-destination (OD) relationship of segment flow data between upstream and downstream on the highway. In order to achieve fine prediction, a generalized extended-segment data acquirement mode is added by incorporating information of Automatic Number Plate Recognition System (ANPRS) from exits and entrances of toll stations and acquired by mathematical OD calculation indirectly without cameras. Abnormal data preprocessing and spatio-temporal relationship matching are conducted to ensure the effectiveness of prediction. Pearson analysis of spatial correlation is performed to find the relevance between adjacent roads, and the relative importance of input modes can be verified by spatial lag input and ordinary input. Two improved models, independent XGBoost (XGBoost-I) with individual adjustment parameters of different sections and static XGBoost (XGBoost-S) with overall adjustment of parameters, are conducted and combined with temporal relevant intervals and spatial staggered sectional lag. The early_stopping_rounds adjustment mechanism (EAM) is introduced to improve the effect of the XGBoost model. The prediction accuracy of XGBoost-I-lag is generally higher than XGBoost-I, XGBoost-S-lag, XGBoost-S, and other baseline methods for short-term and long-term multistep ahead. Additionally, the accuracy of the XGBoost-I-lag is evaluated well in nonrecurrent conditions and missing cases with considerable running time. The experiment results indicate that the proposed framework is convincing, satisfactory, and computationally reasonable.
- Published
- 2021
- Full Text
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42. Optimization Model of Traffic Sensor Layout considering Traffic Big Data
- Author
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Xu Sun, Zixiu Bai, Kun Lin, Pengpeng Jiao, and HuaPu Lu
- Subjects
Transportation engineering ,TA1001-1280 ,Transportation and communications ,HE1-9990 - Abstract
In order to improve the accuracy, reliability, and economy of urban traffic information collection, an optimization model of traffic sensor layout is proposed in this paper. Considering the impact of traffic big data, a set of impact factors for traffic sensor layout is established, including system cost, multisource data sharing, data demand, sensor failures, road infrastructure, and sensor type. The impacts of these influential factors are taken into account in the traffic sensor layout optimization problem, which is formulated in the form of multiobjective programming model that includes minimum system cost, maximum truncation flow, minimum path coverage, and an origin-destination (OD) coverage constraint. The model is solved by the tolerant lexicographic method based on a genetic algorithm. A case study shows that the model reflects the influence of multisource data sharing and fault conditions and satisfies the origin-destination coverage constraint to achieve the multiobjective optimization of traffic sensor layout.
- Published
- 2020
- Full Text
- View/download PDF
43. Pedestrian Arching Mechanism at Bottleneck in Subway Transit Hub
- Author
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Wei Luo, Pengpeng Jiao, and Yi Wang
- Subjects
subway transit hub ,bottleneck ,pedestrian behavior ,simulation experiment ,social force model ,Information technology ,T58.5-58.64 - Abstract
Under the massive pedestrian flow, pedestrians arching phenomenon forms easily at bottleneck in subway hubs, which might stampede and crush. To explore pedestrian arching mechanism at bottleneck in subway transit hub, this paper conducts a series of simulation experiment. Firstly, movement preference characteristic in subway transit hubs was introduced into the social force model which considers multiple force. Then, after setting basic experiment scenario, unidirectional flow at different bottlenecks were simulated. Finally, the mechanism of pedestrian arching phenomenon at bottleneck was quantitative analyzed with the help of experimental data. Some main conclusions are summarized. Pedestrian arching phenomenon could be divided into four stages: Free, arching formation, arching stabilization and arching dissipation. In addition, the relationship between bottleneck scenario and passing time could be built to a function model. With the different of bottleneck width ratio, passing time presents positive correlation. The research results could give some helps for understanding the dynamic evolution process of unidirectional flow at bottleneck, improving the pedestrian efficiency at bottleneck and optimizing pedestrian facilities in subway transit hub.
- Published
- 2021
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44. Study of Preparation, Growth Mechanism and Catalytic Performance of Carbon Based Embedded Silver Nano Composite Materials
- Author
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Pengpeng Jiang, Jiao Liu, Yingxin Huang, Xiaohong Jiang, and Lude Lu
- Subjects
carbon materials ,nanoparticles ,composite materials ,photocatalytic performance ,Chemistry ,QD1-999 - Abstract
Novel and stable carbon based embedded silver nano composite materials (Ag/CSs) were successfully prepared by a facile one-pot hydrothermal method with trioctylamine (TOA) as soft template and stabilizer. These as-prepared Ag/CSs exhibit well-defined shape and relatively uniform size with an average diameter of 1.5 μm and uniformly embedded Ag nanoparticles about 5 nm. The proper proportion of glucose, AgNO3 and TOA is the key to the common growth of hydrothermal carbon materials and silver nanoparticles in an embedded way. Besides, the thickness of carbon sphere matrix and the size of Ag particles can be tailored precisely by adjusting the experimental parameters. In order to facilitate comparative analysis, carbon spheres (CSs) without Ag particles embedded were also prepared with glucose under the same hydrothermal reaction conditions. The composition, structure and morphology of the as-prepared Ag/CSs and CSs were confirmed by X-ray powder diffraction (XRD), FT-IR spectroscopy, Raman spectrum, Transmission electron microscopy (TEM) and scanning electron microscopy (SEM). In addition, the possible formation mechanism of the Ag/CSs has been proposed based on experimental evidences. Finally, the as-prepared Ag/CSs and CSs were used as catalysts in the experiments of photocatalytic degradation of methylene MB in water under visible light irradiation and the high efficiency of photocatalytic performance of Ag/CSs has been verified.
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- 2017
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45. Signal Timing Optimization Model Based on Bus Priority
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Xu Sun, Kun Lin, Pengpeng Jiao, and Huapu Lu
- Subjects
bus priority ,signal timing design ,passenger delay ,optimization model ,Information technology ,T58.5-58.64 - Abstract
This paper focuses on the optimization problem of a signal timing design based on the concept of bus priority. This optimization problem is formulated in the form of a bi-level programming model that minimizes average passenger delay at intersections and vehicle delay in lanes simultaneously. A solution framework that implements the differential evolution (DE) algorithm is developed to efficiently solve the model. A case study based on a real-world intersection in Beijing, China, is implemented to test the efficiency and applicability of the proposed modeling and computing methods. The experiment’s result shows that the optimization model can not only significantly improve the priority capacity of the buses at the intersection but also reduce the adverse impact of bus-priority approaches on the private vehicles for the intersections.
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- 2020
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46. Investigation of Start-Up Characteristics of Thermosyphons Modified with Different Hydrophilic and Hydrophobic Inner Surfaces
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Xiaolong Ma, Zhongchao Zhao, Pengpeng Jiang, Shan Yang, Shilin Li, and Xudong Chen
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thermosyphon ,start-up characteristics ,hydrophilic and hydrophobic ,contact angle ,Technology - Abstract
In this paper, the influence of wettability properties on the start-up characteristics of two-phase closed thermosyphons (TPCTs) is investigated. Chemical coating and etching techniques are performed to prepare the surfaces with different wettabilities that is quantified in the form of the contact angle (CA). The 12 TPCTs are processed including the same CA and a different CA combination on the inner surfaces inside both the evaporator and the condenser sections. For TPCTs with the same wettability properties, the introduction of hydrophilic properties inside the evaporator section not only significantly reduces the start-up time but also decreases the start-up temperature. For example, the start-up time of a TPCT with CA = 28° at 40 W, 60 W and 80 W is 46%, 50% and 55% shorter than that of a TPCT with a smooth surface and the wall superheat degrees is 55%, 39% and 28% lower, respectively. For TPCTs with combined hydrophilic and hydrophobic properties, the start-up time spent on the evaporator section with hydrophilic properties is shorter than that of the hydrophobic evaporator section and the smaller CA on the condenser section shows better results. The start-up time of a TPCT with CA = 28° on the evaporator section and CA = 105° on the condenser section has the best start-up process at 40 W, 60 W and 80 W which is 14%, 22% and 26% shorter than that of a TPCT with smooth surface. Thus, the hydrophilic and hydrophobic modifications play a significant role in promoting the start-up process of a TPCT.
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- 2020
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47. Pareto front–based multi-objective real-time traffic signal control model for intersections using particle swarm optimization algorithm
- Author
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Pengpeng Jiao, Ruimin Li, and Zhihong Li
- Subjects
Mechanical engineering and machinery ,TJ1-1570 - Abstract
Real-time traffic control is very important for urban transportation systems. Due to conflicts among different optimization objectives, the existing multi-objective models often convert into single-objective problems through weighted sum method. To obtain real-time signal parameters and evaluation indices, this article puts forward a Pareto front–based multi-objective traffic signal control model using particle swarm optimization algorithm. The article first formulates a control model for intersections based on detected real-time link volumes, with minimum delay time, minimum number of stops, and maximum effective capacity as three objectives. Moreover, this article designs a step-by-step particle swarm optimization algorithm based on Pareto front for solution. Pareto dominance relation and density distance are employed for ranking, tournament selection is used to select and weed out particles, and Pareto front for the signal timing plan is then obtained, including time-varying cycle length and split. Finally, based on actual survey data, scenario analyses determine the optimal parameters of the particle swarm algorithm, comparisons with the current situation and existing models demonstrate the excellent performances, and the experiments incorporating outliers in the input data or total failure of detectors further prove the robustness. Generally, the proposed methodology is effective and robust enough for real-time traffic signal control.
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- 2016
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48. Real-time traffic signal optimization model based on average delay time per person
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Pengpeng Jiao, Zhihong Li, Meiqi Liu, Dongyue Li, and Yangwei Li
- Subjects
Mechanical engineering and machinery ,TJ1-1570 - Abstract
Real-time traffic signal control is very important for relieving urban traffic congestion. Many existing traffic control models were formulated using optimization approach, with the objective functions of minimizing vehicle delay time. To improve people’s trip efficiency, this article aims to minimize delay time per person. Based on the time-varying traffic flow data at intersections, the article first fits curves of accumulative arrival and departure vehicles, as well as the corresponding functions. Moreover, this article transfers vehicle delay time to personal delay time using average passenger load of cars and buses, employs such time as the objective function, and proposes a signal timing optimization model for intersections to achieve real-time signal parameters, including cycle length and green time. This research further implements a case study based on practical data collected at an intersection in Beijing, China. The average delay time per person and queue length are employed as evaluation indices to show the performances of the model. The results show that the proposed methodology is capable of improving traffic efficiency and is very effective for real-world applications.
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- 2015
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49. Integrated Model of Joint Residence-Workplace Location Choice and Commute Behavior Using Latent Class and Mixed Logit Methods
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Pengpeng Jiao, Meiqi Liu, and Jin Guo
- Subjects
Mathematics ,QA1-939 - Abstract
With the rapid development of urbanization and motorization, urban commute trips are becoming increasingly serious due to the unbalanced distribution of residence and workplace land-use types in most Chinese cities. To explore the inherent interrelations among residence location, workplace, and commute trip, an integrated model framework of joint residence-workplace location choice and commute behavior is put forward based on the personal trip survey data of Beijing in 2005. First, to extract households’ different choice characteristics, this paper presents a latent class model, clusters all households into several groups, and analyzes the conditional probability of each group. Second, the paper integrates the residence location and workplace together as the joint choice alternative, employs the socioeconomic factors, individual attributes, household attributes, and trip characteristics as explanatory variables, and formulates the joint residence-workplace location choice model using mixed logit method. Estimations of the latent class model show that four latent groups fit the data best. Further results of the joint residence-workplace location choice model indicate that there exist significantly different choice characteristics in each latent group. Generally, the integrated model framework outperforms traditional location choice methods.
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- 2015
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50. Joint Residence-Workplace Location Choice Model Based on Household Decision Behavior
- Author
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Pengpeng Jiao, Tuo Sun, Jin Guo, and Yangwei Li
- Subjects
Mathematics ,QA1-939 - Abstract
Residence location and workplace are the two most important urban land-use types, and there exist strong interdependences between them. Existing researches often assume that one choice dimension is correlated to the other. Using the mixed logit framework, three groups of choice models are developed to illustrate such choice dependencies. First, for all households, this paper presents a basic methodology of the residence location and workplace choice without decision sequence based on the assumption that the two choice behaviors are independent of each other. Second, the paper clusters all households into two groups, choosing residence or workplace first, and formulates the residence location and workplace choice models under the constraint of decision sequence. Third, this paper combines the residence location and workplace together as the choice alternative and puts forward the joint choice model. A questionnaire survey is implemented in Beijing city to collect the data of 1994 households. Estimation results indicate that the joint choice model fits the data significantly better, and the elasticity effects analyses show that the joint choice model reflects the influences of relevant factors to the choice probability well and leads to the job-housing balance.
- Published
- 2015
- Full Text
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