1. Occupational Hypersensitivity Pneumonitis in a Japanese Citrus Farmer
- Author
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Katsuhiko Kamei, Takahisa Takihara, Yoko Ito, Koichiro Asano, Hiroshi Kajiwara, Yuma Fukutomi, Mari Takahashi, Yoshiki Shiraishi, Naokata Kutsuzawa, Keito Enokida, Naoki Hayama, Yukihiro Horio, Tadashi Imanishi, and Tsuyoshi Oguma
- Subjects
medicine.medical_specialty ,Citrus ,occupational hypersensitivity pneumonitis ,Case Report ,Lung biopsy ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Penicillium digtatum ,Internal Medicine ,Medicine ,Humans ,Leukocytosis ,Aged ,next generation sequencing ,Penicillium digitatum ,Lung ,Farmers ,biology ,business.industry ,Penicillium ,General Medicine ,biology.organism_classification ,medicine.disease ,Dermatology ,respiratory tract diseases ,medicine.anatomical_structure ,General malaise ,030211 gastroenterology & hepatology ,fungi ,medicine.symptom ,business ,hypersensitivity pneumonitis ,Hypersensitivity pneumonitis ,Mycobiome ,Alveolitis, Extrinsic Allergic - Abstract
Hypersensitivity pneumonitis (HP) sometimes develops in people working in specific environments. We herein report a case of occupation-related HP in a citrus farmer in Japan. A 66-year-old man developed a fever, dyspnea, and general malaise in March after working near a trash dump filled with moldy tangerines. He presented with leukocytosis, bilateral lung opacities on chest radiographs, and intra-alveolar and interstitial lymphocytic inflammation with fibrotic change on a lung biopsy. His symptoms disappeared after admission and recurred on a revisit to the workplace. Fungal culture and a mycobiome analysis using next-generation sequencing suggested an association with exposure to Penicillium digitatum.
- Published
- 2021