1. Progress update from the hippocampal subfields group
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Trevor A. Steve, Katrin Amunts, Olga Kedo, Rosanna K. Olsen, Elliott G. Johnson, Joshua K. Lee, Martina Bocchetta, Ulman Lindenberger, Craig E.L. Stark, Ricardo Insausti, Daniela J. Palombo, Naftali Raz, Margaret L. Schlichting, Gaël Chételat, Valerie A. Carr, Markus Werkle-Bergner, Nanthia Suthana, Paul A. Yushkevich, Jordan DeKraker, Attila Keresztes, Andrew R. Bender, Noa Ofen, John Pluta, Arnold Bakker, David Berron, Karen M. Rodrigue, Kristen M. Kennedy, Robert S. C. Amaral, Prabesh Kanel, Renaud La Joie, Mirjam I. Geerlings, Susanne G. Mueller, Qijing Yu, Songlin Ding, Jean C. Augustinack, Laura E.M. Wisse, Marina Boccardi, Lei Wang, Lorenzo Pasquini, Yee Lee Shing, Ana M. Daugherty, Elizabeth M. Mulligan, Robin de Flores, Yushan Huang, M. Mallar Chakravarty, Alison C. Burggren, Rotman Research Institute at the Baycrest Centre (RRI), University of Toronto, San Jose State University [San José] (SJSU), Wayne State University [Detroit], Memory and Aging Center [San Francisco, CA, États-Unis], University of California [San Francisco] (UCSF), University of California-University of California, Douglas Mental Health University Institute [Montréal], McGill University = Université McGill [Montréal, Canada], Institute of Neuroscience and Medicine [Jülich] (INM-1), Massachusetts General Hospital [Boston], Johns Hopkins University School of Medicine [Baltimore], Lund University [Lund], German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Neuroimaging and Telemedicine (LENITEM), IRCCS Fatebenefratelli - Brescia, Dementia Research Centre [London] (DRC), University College of London [London] (UCL), University of Oregon [Eugene], Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), GIP Cyceron (Cyceron), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU), University of Western Ontario (UWO), Allen Institute for Brain Science [Seattle, WA, USA], University Medical Center [Utrecht], University of Alberta, Human Neuroanatomy Laboratory [Albacete, Spain] (School of Medicine - CRIB), University of Castilla-La Mancha (UCLM)-Centro Regional de Investigaciones Biomédicas (CRIB), University of California, University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], University of Texas at Dallas [Richardson] (UT Dallas), Max Planck Institute for Human Development, Max-Planck-Gesellschaft, University of California [Davis] (UC Davis), Freie Universität Berlin, Florida State University [Tallahassee] (FSU), Weizmann Institutes of Science [Rehovot, Israel], University of British Columbia (UBC), University of Pennsylvania [Philadelphia], Goethe-University Frankfurt am Main, University of California [Irvine] (UCI), University of California [Los Angeles] (UCLA), Northwestern University Feinberg School of Medicine, Penn Image Computing & Science Lab [Philadelphia] (PICSL), The work on this article was also supported by NIH grant R01 AG-011230 to Naftali Raz, NIH grant R01 AG-055121 to Lei Wang, NIH grant R01 AG-056014 to Paul Yushkevich, and NIH grant R01 AG-034613 to Craig Stark. M.M.C. receives salary support from the Fonds du Recherches Santes Quebec and also acknowledges support from NSERC, Weston Brain Institute, and CIHR., Hippocampal Subfields Group, San Jose State University [San Jose] (SJSU), University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM)-Centro Regional de Investigaciones Biomédicas (CRIB), University of California (UC), University of Pennsylvania, University of California [Irvine] (UC Irvine), and CHETELAT, Gaëlle
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Histology ,Standardization ,Computer science ,Clinical Neurology ,Structural imaging ,Neuroimaging ,lcsh:Geriatrics ,Hippocampal formation ,Hippocampus ,lcsh:RC346-429 ,Special Section: Working Group Summaries for the European Joint Programme for Neurodegenerative Disease Research (JPND). (Guest Editors: Jorge Jovicich & Giovanni B. Frisoni) ,Temporal lobe ,ddc:616.89 ,03 medical and health sciences ,0302 clinical medicine ,Volumetry ,Segmentation ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,ddc:610 ,lcsh:Neurology. Diseases of the nervous system ,Reliability (statistics) ,030304 developmental biology ,Protocol (science) ,0303 health sciences ,ex vivo ,International working group ,Data science ,Ex vivo ,3. Good health ,lcsh:RC952-954.6 ,Psychiatry and Mental health ,Neuroanatomy ,Cytoarchitec- ture ,Cytoarchitecture ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Neurology (clinical) ,030217 neurology & neurosurgery ,Human - Abstract
Introduction Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide., Highlights • Harmonization of MRI-based segmentation of medial temporal regions is needed. • The Hippocampal Subfield Group includes >200 imaging and anatomy experts worldwide. • Reliable and valid protocol based on specialized histology data set in development. • A modified Delphi procedure is used to determine consensus on protocol rules. • Final protocol will provide subfield delineation in hippocampal body, head, and tail.
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- 2019