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2. Recent developments in genetics and medically assisted reproduction: from research to clinical applications

Author

Harper, J. C., Aittomäki, K., Borry, P., Cornel, M. C., de Wert, G., Dondorp, W., Geraedts, J., Gianaroli, L., Ketterson, K., Liebaers, I., Lundin, K., Mertes, H., Morris, M., Pennings, G., Sermon, K., Spits, C., Soini, S., van Montfoort, A. P. A., Veiga, A., Vermeesch, J. R., Viville, S., Macek Jr., M., and on behalf of the European Society of Human Reproduction and Embryology and European Society of Human Genetics

Published
2018
Full Text
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5. Oocyte vitrification for elective fertility preservation: a SWOT analysis

Author

Gil-Arribas E, Blockeel C, Pennings G, Nekkebroeck J, Velasco JAG, Serna J, and De Vos M

Subjects
Egg freezing, Female emancipation, Fertility preservation, Oocyte cryopreservation, Social fertility preservation, Vitrification
Abstract

Oocyte vitrification, also known as egg freezing, is increasingly being used by women as a precautionary measure against the anticipated decline in fertility. In countries where this procedure is allowed, elective oocyte vitrification has become an integral part of the treatment portfolio of fertility clinics. The widespread tendency towards the postponement of motherhood and the advances in laboratory technologies are encouraging women to consider oocyte vitrification and, by doing so, increase their reproductive autonomy. However, elective oocyte vitrification, or elective egg freezing (EEF), still elicits controversy, not only when EEF is appraised from a cost-efficiency point of view, but also in terms of medical and ethical concerns. In general, although the laboratory tool of vitrification has revolutionized the treatment of infertility, the pros and cons need to be clarified when considering EEF.

Published
2022

18. Fertility preservation in boys: recent developments and new insights

Author

Goossens, E., Jahnukainen, K., Mitchell, R.T., Pelt, A. van, Pennings, G., Rives, N., Poels, J., Wyns, C., Lane, S. Mac, Rodriguez-Wallberg, K.A., Rives, A., Valli-Pulaski, H., Steimer, S., Kliesch, S., Braye, A., Andres, M.M., Medrano, J., Ramos, L., Kristensen, S.G., Andersen, C.Y., Bjarnason, R., Orwig, K.E., Neuhaus, N., Stukeborg, J.B., Goossens, E., Jahnukainen, K., Mitchell, R.T., Pelt, A. van, Pennings, G., Rives, N., Poels, J., Wyns, C., Lane, S. Mac, Rodriguez-Wallberg, K.A., Rives, A., Valli-Pulaski, H., Steimer, S., Kliesch, S., Braye, A., Andres, M.M., Medrano, J., Ramos, L., Kristensen, S.G., Andersen, C.Y., Bjarnason, R., Orwig, K.E., Neuhaus, N., and Stukeborg, J.B.

Abstract

Contains fulltext : 229423.pdf (publisher's version ) (Open Access)

Published
2020

19. Fertility preservation in boys: recent developments and new insights .

Author

UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie, Goossens, E, Jahnukainen, K, Mitchell, R T, van Pelt, Amm, Pennings, G, Rives, N, Poels, J, Wyns, Christine, Lane, S, Rodriguez-Wallberg, K A, Rives, A, Valli-Pulaski, H, Steimer, S, Kliesch, S, Braye, A, Andres, M M, Medrano, J, Ramos, L, Kristensen, S G, Andersen, C Y, Bjarnason, R, Orwig, K E, Neuhaus, N, Stukenborg, J B, UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie, Goossens, E, Jahnukainen, K, Mitchell, R T, van Pelt, Amm, Pennings, G, Rives, N, Poels, J, Wyns, Christine, Lane, S, Rodriguez-Wallberg, K A, Rives, A, Valli-Pulaski, H, Steimer, S, Kliesch, S, Braye, A, Andres, M M, Medrano, J, Ramos, L, Kristensen, S G, Andersen, C Y, Bjarnason, R, Orwig, K E, Neuhaus, N, and Stukenborg, J B

Abstract

BACKGROUND: Infertility is an important side effect of treatments used for cancer and other non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells (SSCs) and/or altered functionality of testicular somatic cells (e.g. Sertoli cells, Leydig cells). Whereas sperm cryopreservation is the first-line procedure to preserve fertility in post-pubertal males, this option does not exist for prepubertal boys. For patients unable to produce sperm and at high risk of losing their fertility, testicular tissue freezing is now proposed as an alternative experimental option to safeguard their fertility. OBJECTIVE AND RATIONALE: With this review, we aim to provide an update on clinical practices and experimental methods, as well as to describe patient management inclusion strategies used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss. SEARCH METHODS: Based on the expertise of the participating centres and a literature search of the progress in clinical practices, patient management strategies and experimental methods used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss were identified. In addition, a survey was conducted amongst European and North American centres/networks that have published papers on their testicular tissue banking activity. OUTCOMES: Since the first publication on murine SSC transplantation in 1994, remarkable progress has been made towards clinical application: cryopreservation protocols for testicular tissue have been developed in animal models and are now offered to patients in clinics as a still experimental procedure. Transplantation methods have been adapted for human testis, and the efficiency and safety of the technique are being evaluated in mouse and primate models. However, important practical, medical and ethical issues must be resolved before fertility restoration can be applied in the clinic.Since the previous survey conducted in 201

Published
2020

20. Fertility preservation in boys:recent developments and new insights †

Author

Goossens, E, Jahnukainen, K, Mitchell, R T, van Pelt, Amm, Pennings, G, Rives, N, Poels, J, Wyns, C, Lane, S, Rodriguez-Wallberg, K A, Rives, A, Valli-Pulaski, H, Steimer, S, Kliesch, S, Braye, A, Andres, M M, Medrano, J, Ramos, L, Kristensen, S G, Andersen, C Y, Bjarnason, R, Orwig, K E, Neuhaus, N, Stukenborg, J B, Goossens, E, Jahnukainen, K, Mitchell, R T, van Pelt, Amm, Pennings, G, Rives, N, Poels, J, Wyns, C, Lane, S, Rodriguez-Wallberg, K A, Rives, A, Valli-Pulaski, H, Steimer, S, Kliesch, S, Braye, A, Andres, M M, Medrano, J, Ramos, L, Kristensen, S G, Andersen, C Y, Bjarnason, R, Orwig, K E, Neuhaus, N, and Stukenborg, J B

Abstract

BACKGROUND: Infertility is an important side effect of treatments used for cancer and other non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells (SSCs) and/or altered functionality of testicular somatic cells (e.g. Sertoli cells, Leydig cells). Whereas sperm cryopreservation is the first-line procedure to preserve fertility in post-pubertal males, this option does not exist for prepubertal boys. For patients unable to produce sperm and at high risk of losing their fertility, testicular tissue freezing is now proposed as an alternative experimental option to safeguard their fertility.OBJECTIVE AND RATIONALE: With this review, we aim to provide an update on clinical practices and experimental methods, as well as to describe patient management inclusion strategies used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss.SEARCH METHODS: Based on the expertise of the participating centres and a literature search of the progress in clinical practices, patient management strategies and experimental methods used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss were identified. In addition, a survey was conducted amongst European and North American centres/networks that have published papers on their testicular tissue banking activity.OUTCOMES: Since the first publication on murine SSC transplantation in 1994, remarkable progress has been made towards clinical application: cryopreservation protocols for testicular tissue have been developed in animal models and are now offered to patients in clinics as a still experimental procedure. Transplantation methods have been adapted for human testis, and the efficiency and safety of the technique are being evaluated in mouse and primate models. However, important practical, medical and ethical issues must be resolved before fertility restoration can be applied in the clinic.Since the previous su

Published
2020

40. Fertility preservation in boys: recent developments and new insights †

Author

Goossens, E, primary, Jahnukainen, K, primary, Mitchell, RT, primary, van Pelt, AMM, primary, Pennings, G, primary, Rives, N, primary, Poels, J, primary, Wyns, C, primary, Lane, S, primary, Rodriguez-Wallberg, KA, primary, Rives, A, primary, Valli-Pulaski, H, primary, Steimer, S, primary, Kliesch, S, primary, Braye, A, primary, Andres, MM, primary, Medrano, J, primary, Ramos, L, primary, Kristensen, SG, primary, Andersen, CY, primary, Bjarnason, R, primary, Orwig, KE, primary, Neuhaus, N, primary, and Stukenborg, JB, primary

Published
2020
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45. Cross-border reproductive care in Belgium

Author

Pennings, G, Autin, C, Decleer, W, Delbaere, A, Delbeke, L, Delvigne, A, De Neubourg, D, Devroey, P, Dhont, M, DʼHooghe, T, Gordts, S, Lejeune, B, Nijs, M, Pauwels, P, Perrad, B, Pirard, C, and Vandekerckhove, F

Published
2009

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