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2. Identification of primary mediastinal B-cell lymphomas with higher clonal dominance and poorer outcome using 5′RACE

Author

Camus, Vincent, Viennot, Mathieu, Viailly, Pierre-Julien, Drieux, Fanny, Veresezan, Elena-Liana, Bobée, Victor, Rainville, Vinciane, Bohers, Elodie, Sesques, Pierre, Haioun, Corinne, Durot, Eric, Bayaram, Michael, Rossi, Cédric, Martin, Laurent, Penther, Dominique, Kaltenbach, Sophie, Bruneau, Julie, Paillassa, Jérome, Tournilhac, Olivier, Gower, Nicolas, Willaume, Alexandre, Antier, Chloé, Renaud, Loïc, Lévêque, Emilie, Decazes, Pierre, Becker, Stéphanie, Tonnelet, David, Gaulard, Philippe, Tilly, Hervé, Molina, Thierry Jo, Traverse-Glehen, Alexandra, Donzel, Marie, Ruminy, Philippe, and Jardin, Fabrice

Published
2024
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3. High PDL1/PDL2 gene expression correlates with worse outcome in primary mediastinal large B-cell lymphoma

Author

Camus, Vincent, Viailly, Pierre-Julien, Drieux, Fanny, Veresezan, Elena-Liana, Sesques, Pierre, Haioun, Corinne, Durot, Eric, Patey, Martine, Rossi, Cédric, Martin, Laurent, Rainville, Vinciane, Bohers, Elodie, Ruminy, Philippe, Penther, Dominique, Kaltenbach, Sophie, Bruneau, Julie, Paillassa, Jérome, Tournilhac, Olivier, Willaume, Alexandre, Antier, Chloé, Lazarovici, Julien, Lévêque, Emilie, Decazes, Pierre, Becker, Stéphanie, Tonnelet, David, Berriolo-Riedinger, Alina, Gaulard, Philippe, Tilly, Hervé, Molina, Thierry Jo, Traverse-Glehen, Alexandra, and Jardin, Fabrice

Published
2023
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7. The t(X;20)(q13;q13) translocation is a good prognostic factor in myeloid neoplasms: A report of 25 cases from the Groupe Francophone de Cytogénétique Hématologique

Author

Nguyen‐Khac, Florence, primary, Muller, Marc, additional, Chapiro, Elise, additional, Abermil, Nassera, additional, Collonge‐Rame, Marie‐Agnes, additional, Daudignon, Agnes, additional, Gaillard, Baptiste, additional, Guzun, Doina, additional, Ittel, Antoine, additional, Lefebvre, Christine, additional, Lesesve, Jean‐Francois, additional, Mozziconacci, Marie‐Joelle, additional, Penther, Dominique, additional, Quessada, Julie, additional, Settegrana, Catherine, additional, Smagghe, Luce, additional, Terre, Christine, additional, Veronese, Lauren, additional, Hirsch, Pierre, additional, and Troadec, Marie‐Bérengère, additional

Published
2024
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8. The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11

Author

Lafage-Pochitaloff, Marina, Gerby, Bastien, Baccini, Véronique, Largeaud, Laetitia, Fregona, Vincent, Prade, Naïs, Juvin, Pierre-Yves, Jamrog, Laura, Bories, Pierre, Hébrard, Sylvie, Lagarde, Stéphanie, Mas, Véronique Mansat-De, Dovey, Oliver M, Yusa, Kosuke, Vassiliou, George S, Jansen, Joop H., Tekath, Tobias, Rombaut, David, Ameye, Geneviève, Barin, Carole, Bidet, Audrey, Boudjarane, John, Collonge-Rame, Marie-Agnès, Gervais, Carine, Ittel, Antoine, Lefebvre, Christine, Luquet, Isabelle, Michaux, Lucienne, Nadal, Nathalie, Poirel, Hélène A., Radford-Weiss, Isabelle, Ribourtout, Bénédicte, Richebourg, Steven, Struski, Stéphanie, Terré, Christine, Tigaud, Isabelle, Penther, Dominique, Eclache, Virginie, Fontenay, Michaela, Broccardo, Cyril, and Delabesse, Eric

Published
2021
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12. Complete hematologic response after belinostat treatment and allogeneic stem cell transplantation for multiple relapsed/refractory angioimmunoblastic T-cell lymphoma: a case report

Author

Camus, Vincent, primary, Etancelin, Pascaline, additional, Drieux, Fanny, additional, Veresezan, Elena-Liana, additional, PICQUENOT, Jean-MIchel, additional, Penther, Dominique, additional, Viennot, Mathieu, additional, Ruminy, Philippe, additional, Contentin, Nathalie, additional, Lemasle, Emilie, additional, lepretre, stephane, additional, Dubois, Sydney, additional, Penichoux, Juliette, additional, Stamatoullas, Aspasia, additional, Zduniak, Alexandra, additional, Lanic, Helene, additional, and Jardin, Fabrice, additional

Published
2023
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13. Supplementary Data from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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14. Table S5. Cohort variants. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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15. Table S2. Cell of origin according to MYD88 mutations. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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16. Table S7. Immunohistochemical markers and gene rearrangements according to MYD88 variants. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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17. Table S10. Clinical characteristics of patients with CNS relapse. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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18. Table S1. Clinical and immunohistochemical data according to MYD88 mutation status. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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19. Table S6. Cohort copy number variations. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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20. Supplementary Figures from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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21. Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms

Author

Emadali, Anouk, Hoghoughi, Neda, Duley, Samuel, Hajmirza, Azadeh, Verhoeyen, Els, Cosset, Francois-Loic, Bertrand, Philippe, Roumier, Christophe, Roggy, Anne, Suchaud-Martin, Céline, Chauvet, Martine, Bertrand, Sarah, Hamaidia, Sieme, Rousseaux, Sophie, Josserand, Véronique, Charles, Julie, Templier, Isabelle, Maeda, Takahiro, Bruder-Costa, Juliana, Chaperot, Laurence, Plumas, Joel, Jacob, Marie-Christine, Bonnefoix, Thierry, Park, Sophie, Gressin, Remy, Tensen, Cornelis P., Mecucci, Cristina, Macintyre, Elizabeth, Leroux, Dominique, Brambilla, Elisabeth, Nguyen-Khac, Florence, Luquet, Isabelle, Penther, Dominique, Bastard, Christian, Jardin, Fabrice, Lefebvre, Christine, Garnache, Francine, and Callanan, Mary B.

Published
2016
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22. High PDL1/PDL2gene expression correlates with worse outcome in primary mediastinal large B-cell lymphoma

Author

Camus, Vincent, Viailly, Pierre-Julien, Drieux, Fanny, Veresezan, Elena-Liana, Sesques, Pierre, Haioun, Corinne, Durot, Eric, Patey, Martine, Rossi, Cédric, Martin, Laurent, Rainville, Vinciane, Bohers, Elodie, Ruminy, Philippe, Penther, Dominique, Kaltenbach, Sophie, Bruneau, Julie, Paillassa, Jérome, Tournilhac, Olivier, Willaume, Alexandre, Antier, Chloé, Lazarovici, Julien, Lévêque, Emilie, Decazes, Pierre, Becker, Stéphanie, Tonnelet, David, Berriolo-Riedinger, Alina, Gaulard, Philippe, Tilly, Hervé, Molina, Thierry Jo, Traverse-Glehen, Alexandra, and Jardin, Fabrice

Abstract

•PMBL cases with high gene expression of both PDL1and PDL2 represent a subset of 30% of the population.•These patients have strong immune privilege and poorer outcomes.

Published
2023
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23. “Double‐hit” chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain

Author

Chapiro, Elise, Lesty, Claude, Gabillaud, Clémentine, Durot, Eric, Bouzy, Simon, Armand, Marine, Le Garff‐Tavernier, Magali, Bougacha, Nadia, Struski, Stéphanie, Bidet, Audrey, Laharanne, Elodie, Barin, Carole, Veronese, Lauren, Prié, Nolwen, Eclache, Virginie, Gaillard, Baptiste, Michaux, Lucienne, Lefebvre, Christine, Gaillard, Jean‐Baptiste, Terré, Christine, Penther, Dominique, Bastard, Christian, Nadal, Nathalie, Fert‐Ferrer, Sandra, Auger, Nathalie, Godon, Catherine, Sutton, Laurent, Tournilhac, Olivier, Susin, Santos A., and Nguyen‐Khac, Florence

Published
2018
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24. Complete hematologic response after belinostat treatment and allogeneic stem cell transplantation for multiple relapsed/refractory angioimmunoblastic T‐cell lymphoma: A case report.

Author

Camus, Vincent, Etancelin, Pascaline, Drieux, Fanny, Veresezan, Elena‐Liana, Picquenot, Jean‐Michel, Penther, Dominique, Viennot, Mathieu, Ruminy, Philippe, Contentin, Nathalie, Lemasle, Emilie, Leprêtre, Stéphane, Dubois, Sydney, Penichoux, Juliette, Stamatoullas, Aspasia, Zduniak, Alexandra, Lanic, Hélène, and Jardin, Fabrice

Subjects
STEM cell transplantation, T-cell lymphoma, STEM cell treatment
Abstract

Key Clinical Message: This case report highlights the potential of belinostat for the treatment of relapsed/refractory peripheral T‐cell lymphomas, for which effective therapies are still scarce. Peripheral T‐cell lymphomas have an aggressive disease course associated with poor outcomes. We report a young patient with highly pretreated relapsed/refractory nodal follicular helper T‐cell lymphoma (angioimmunoblastic‐type [nTFHL‐AI]), who successfully received an allogeneic stem cell transplantation following belinostat therapy. The complete hematologic response achieved has lasted more than 2 years. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature

Author

Chapiro, Elise, Radford-Weiss, Isabelle, Cung, Hong-Anh, Dastugue, Nicole, Nadal, Nathalie, Taviaux, Sylvie, Barin, Carole, Struski, Stephanie, Talmant, Pascaline, Vandenberghe, Peter, Mozziconacci, Marie-Joelle, Tigaud, Isabelle, Lefebvre, Christine, Penther, Dominique, Bastard, Christian, Lippert, Eric, Mugneret, Francine, Romana, Serge, Bernard, Olivier A., Harrison, Christine J., Russell, Lisa J., and Nguyen-Khac, Florence

Published
2013
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26. Oncogenic events rather than antigen selection pressure may be the main driving forces for relapse in diffuse large B‐cell lymphomas

Author

Rizzo, David, Viailly, Pierre‐Julien, Mareschal, Sylvain, Bohers, Elodie, Picquenot, Jean‐Michel, Penther, Dominique, Dubois, Sydney, Marchand, Vinciane, Bertrand, Philippe, Maingonnat, Catherine, Etancelin, Pascaline, Feuillard, Jean, Bastard, Christian, Tilly, Hervé, Jardin, Fabrice, and Ruminy, Philippe

Published
2017
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28. The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11

Author

Lafage-Pochitaloff, Marina, primary, Gerby, Bastien, additional, Baccini, Véronique, additional, Largeaud, Laetitia, additional, Fregona, Vincent, additional, Prade, Naïs, additional, Juvin, Pierre-Yves, additional, Jamrog, Laura, additional, Bories, Pierre, additional, Hébrard, Sylvie, additional, Lagarde, Stéphanie, additional, Mansat-De Mas, Véronique, additional, Dovey, Oliver M., additional, Yusa, Kosuke, additional, Vassiliou, George S., additional, Jansen, Joop H., additional, Tekath, Tobias, additional, Rombaut, David, additional, Ameye, Geneviève, additional, Barin, Carole, additional, Bidet, Audrey, additional, Boudjarane, John, additional, Collonge-Rame, Marie-Agnès, additional, Gervais, Carine, additional, Ittel, Antoine, additional, Lefebvre, Christine, additional, Luquet, Isabelle, additional, Michaux, Lucienne, additional, Nadal, Nathalie, additional, Poirel, Hélène A., additional, Radford-Weiss, Isabelle, additional, Ribourtout, Bénédicte, additional, Richebourg, Steven, additional, Struski, Stéphanie, additional, Terré, Christine, additional, Tigaud, Isabelle, additional, Penther, Dominique, additional, Eclache, Virginie, additional, Fontenay, Michaela, additional, Broccardo, Cyril, additional, and Delabesse,, Eric, additional

Published
2022
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30. Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogénétique Hématologique study

Author

Coyaud, Etienne, Struski, Stephanie, Prade, Nais, Familiades, Julien, Eichner, Ruth, Quelen, Cathy, Bousquet, Marina, Mugneret, Francine, Talmant, Pascaline, Pages, Marie-Pierre, Lefebvre, Christine, Penther, Dominique, Lippert, Eric, Nadal, Nathalie, Taviaux, Sylvie, Poppe, Bruce, Luquet, Isabelle, Baranger, Laurence, Eclache, Virginie, Radford, Isabelle, Barin, Carole, Mozziconacci, Marie-Joëlle, Lafage-Pochitaloff, Marina, Antoine-Poirel, Hélène, Charrin, Christiane, Perot, Christine, Terre, Christine, Brousset, Pierre, Dastugue, Nicole, and Broccardo, Cyril

Published
2010
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32. Concomitant occurrence of genetically distinct Hodgkin lymphoma and primary mediastinal lymphoma

Author

Dubois, Sydney, primary, Ruminy, Philippe, additional, Bohers, Elodie, additional, Viailly, Pierre‐Julien, additional, Veresezan, Liana, additional, Picquenot, Jean‐Michel, additional, Bobée, Victor, additional, Viennot, Mathieu, additional, Penther, Dominique, additional, Camus, Vincent, additional, Thieblemont, Catherine, additional, Pouaty, Camille, additional, Tilly, Hervé, additional, and Jardin, Fabrice, additional

Published
2021
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33. Optical genome mapping, a promising alternative to gold standard cytogenetic approaches in a series of acute lymphoblastic leukemias

Author

Lestringant, Valentin, primary, Duployez, Nicolas, additional, Penther, Dominique, additional, Luquet, Isabelle, additional, Derrieux, Coralie, additional, Lutun, Anne, additional, Preudhomme, Claude, additional, West, Michaela, additional, Ouled‐Haddou, Hakim, additional, Devoldere, Catherine, additional, Marolleau, Jean‐Pierre, additional, Garçon, Loïc, additional, Jedraszak, Guillaume, additional, and Ferret, Yann, additional

Published
2021
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34. Additional file 1 of Improving high-resolution copy number variation analysis from next generation sequencing using unique molecular identifiers

Author

Viailly, Pierre-Julien, Sater, Vincent, Viennot, Mathieu, Bohers, Elodie, Vergne, Nicolas, Berard, Caroline, Dauchel, Hélène, Lecroq, Thierry, Celebi, Alison, Ruminy, Philippe, Marchand, Vinciane, Marie-Delphine Lanic, Dubois, Sydney, Penther, Dominique, Tilly, Hervé, Mareschal, Sylvain, and Jardin, Fabrice

Abstract

Additional file 1. Supplementary Figures S1–S5, Supplementary Tables S1–S3.

Published
2021
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35. Clinical and biological features of B‐cell neoplasms with CDK6 translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and TP53 abnormalities

Author

Gailllard, Baptiste, Cornillet‐Lefebvre, Pascale, Le, Quoc‐Hung, Maloum, Karim, Pannetier, Mélanie, Lecoq‐Lafon, Carinne, Grange, Béatrice, Jondreville, Ludovic, Michaux, Lucienne, Nadal, Nathalie, Ittel, Antoine, Luquet, Isabelle, Struski, Stéphanie, Lefebvre, Christine, Gaillard, Jean‐Baptiste, Lafage‐Pochitaloff, Marina, Balducci, Estelle, Penther, Dominique, Barin, Carole, Collonge‐Rame, Marie Agnès, Jimenez‐Poquet, Mélanie, Richebourg, Steven, Defasque, Sabine, Radford‐Weiss, Isabelle, Bidet, Audrey, Susin, Santos, Nguyen‐Khac, Florence, Chapiro, Elise, Lemaire, Pierre, Hôpital universitaire Robert Debré [Reims], Service d'Hématologie Biologique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pontchaillou [Rennes], Hospices Civils de Lyon (HCL), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), University Hospitals Leuven [Leuven], CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Strasbourg, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire [Grenoble] (CHU), Unité de Génétique Chromosomique [Montpellier], Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée [Montpellier], Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de pédiatrie, d'hématologie et d'oncologie [Hôpital de La Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Paul Brousse, Département de génétique [CHU Rouen] (Centre Normandie de Génomique et de Médecine Personnalisée), CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laborizon Abo+, Faculté de médecine de l'Université Laval [Québec] (ULaval), Université Laval [Québec] (ULaval), Laboratoire CERBA [Saint Ouen l'Aumône], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université Paris Cité (UPCité), Gestionnaire, HAL Sorbonne Université 5, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Paris (UP)

Subjects
Adult, Male, [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, CDK6, Trisomy, CD5 Antigens, Translocation, Genetic, prolymphocytic cell, Humans, TP53, In Situ Hybridization, Fluorescence, Aged, Aged, 80 and over, Chromosome Aberrations, Splenic Neoplasms, Bronchial Neoplasms, Cell Differentiation, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Cyclin-Dependent Kinase 6, Lymphoma, B-Cell, Marginal Zone, Middle Aged, Genes, p53, Leukemia, Lymphocytic, Chronic, B-Cell, Survival Analysis, marginal zone lymphoma, CD5, Phenotype, Tertiary Lymphoid Structures, Mutation, Female, Tumor Suppressor Protein p53, Immunoglobulin Heavy Chains
Abstract

International audience; A translocation involving the cyclin‐dependent kinase 6 (CDK6) gene [t(CDK6)] is a rare but recurrent abnormality in B‐cell neoplasms. To further characterise this aberration, we studied 57 cases; the largest series reported to date. Fluorescence in situ hybridisation analysis confirmed the involvement of CDK6 in all cases, including t(2;7)(p11;q21) immunoglobulin kappa locus (IGK)/CDK6 (n = 51), t(7;14)(q21;q32) CDK6/immunoglobulin heavy locus (IGH) (n = 2) and the previously undescribed t(7;14)(q21;q11) CDK6/T‐cell receptor alpha locus (TRA)/T‐cell receptor delta locus (TRD) (n = 4). In total, 10 patients were diagnosed with chronic lymphocytic leukaemia, monoclonal B‐cell lymphocytosis or small lymphocytic lymphoma, and 47 had small B‐cell lymphoma (SmBL) including 36 cases of marginal zone lymphoma (MZL; 34 splenic MZLs, one nodal MZL and one bronchus‐associated lymphoid tissue lymphoma). In all, 18 of the 26 cytologically reviewed cases of MZL (69%) had an atypical aspect with prolymphocytic cells. Among the 47 patients with MZL/SmBL, CD5 expression was found in 26 (55%) and the tumour protein p53 (TP53) deletion in 22 (47%). The TP53 gene was mutated in 10/30 (33%); the 7q deletion was detected in only one case, and no Notch receptor 2 (NOTCH2) mutations were found. Immunoglobulin heavy‐chain variable‐region (IGHV) locus sequencing revealed that none harboured an IGHV1‐02*04 gene. Overall survival was 82% at 10 years and not influenced by TP53 aberration. Our present findings suggest that most t(CDK6)+ neoplasms correspond to a particular subgroup of indolent marginal zone B‐cell lymphomas with distinctive features.

Published
2020

36. Prognostic relevance of lymphocyte-to-monocyte ratio in primary myelodysplastic syndromes: a single center experience

Author

Pénichoux, Juliette, primary, Dubois, Sydney, additional, Krzisch, Daphné, additional, Menard, Anne-Lise, additional, Lanic, Hélène, additional, Camus, Vincent, additional, Lemasle, Emilie, additional, Leprêtre, Stéphane, additional, Lenain, Pascal, additional, Contentin, Nathalie, additional, Daliphard, Sylvie, additional, Buchonnet, Gérard, additional, Penther, Dominique, additional, Bastard, Christian, additional, Tilly, Hervé, additional, Jardin, Fabrice, additional, and Stamatoullas, Aspasia, additional

Published
2021
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37. Successful treatment of T/myeloid mixed‐phenotype acute leukemia with the translocation (10;11)(p13;q14) PICALM/AF10 with 3 + 7 myeloid standard treatment: A case report

Author

Krzisch, Daphné, primary, Zduniak, Alexandra, additional, Veresezan, Elena‐Liana, additional, Daliphard, Sylvie, additional, Contentin, Nathalie, additional, Penther, Dominique, additional, Etancelin, Pascaline, additional, Jardin, Fabrice, additional, and Camus, Vincent, additional

Published
2021
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38. Optical Mapping, a Promising Alternative to Gold Standard Cytogenetic Approaches in Acute Lymphoblastic Leukemias: A Blind Comparison on 10 Patients

Author

Lestringant, Valentin, primary, Duployez, Nicolas, additional, Penther, Dominique, additional, Grardel, Nathalie, additional, Lutun, Anne, additional, Preudhomme, Claude, additional, West, Michaela, additional, Lee, Joyce, additional, Marolleau, Jean-Pierre, additional, Garçon, Loïc, additional, and Ferret, Yann, additional

Published
2020
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41. B-ALL With t(5;14)(q31;q32); IGH-IL3 Rearrangement and Eosinophilia: A Comprehensive Analysis of a Peculiar IGH-Rearranged B-ALL

Author

Fournier, Benjamin, primary, Balducci, Estelle, additional, Duployez, Nicolas, additional, Clappier, Emmanuelle, additional, Cuccuini, Wendy, additional, Arfeuille, Chloé, additional, Caye-Eude, Aurélie, additional, Delabesse, Eric, additional, Bottollier-Lemallaz Colomb, Elodie, additional, Nebral, Karin, additional, Chrétien, Marie-Lorraine, additional, Derrieux, Coralie, additional, Cabannes-Hamy, Aurélie, additional, Dumezy, Florent, additional, Etancelin, Pascaline, additional, Fenneteau, Odile, additional, Frayfer, Jamile, additional, Gourmel, Antoine, additional, Loosveld, Marie, additional, Michel, Gérard, additional, Nadal, Nathalie, additional, Penther, Dominique, additional, Tigaud, Isabelle, additional, Fournier, Elise, additional, Reismüller, Bettina, additional, Attarbaschi, Andishe, additional, Lafage-Pochitaloff, Marina, additional, and Baruchel, André, additional

Published
2019
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43. A recurrent clonally distinct Burkitt lymphoma case highlights genetic key events contributing to oncogenesis.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Penther, Dominique, Viailly, Pierre-Julien, Latour, Sylvain, Etancelin, Pascaline, Bohers, Elodie, Vellemans, Hélène, Camus, Vincent, Menard, Anne Lise, Coutant, Sophie, Lanic, Hélène, Lemasle, Emilie, Drieux, Fanny, Veresezan, Liana, Ruminy, Philippe, Raimbault, Anna, Soulier, Jean, Frebourg, Thierry, Tilly, Hervé, Jardin, Fabrice, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Penther, Dominique, Viailly, Pierre-Julien, Latour, Sylvain, Etancelin, Pascaline, Bohers, Elodie, Vellemans, Hélène, Camus, Vincent, Menard, Anne Lise, Coutant, Sophie, Lanic, Hélène, Lemasle, Emilie, Drieux, Fanny, Veresezan, Liana, Ruminy, Philippe, Raimbault, Anna, Soulier, Jean, Frebourg, Thierry, Tilly, Hervé, and Jardin, Fabrice

Abstract

Burkitt lymphoma (BL) is characterized by a translocation of the MYC oncogene that leads to the upregulation of MYC expression, cell growth and proliferation. It is well-established that MYC translocation is not a sufficient genetic event to cause BL. Next-generation sequencing has recently provided a comprehensive analysis of the landscape of additional genetic events that contribute to BL lymphomagenesis. Refractory BL or relapsing BL are almost always incurable as a result of the selection of a highly chemoresistant clonally related cell population. Conversely, a few BL recurrence cases arising from clonally distinct tumors have been reported and were associated with a favorable outcome similar to that reported for first-line treatment. Here, we used an unusual case of recurrent but clonally distinct EBV+ BL to highlight the key genetic events that drive BL lymphomagenesis. By whole exome sequencing, we established that ID3 gene was targeted by distinct mutations in the two clonally unrelated diseases, highlighting the crucial role of this gene during lymphomagenesis. We also detected a heterozygous E1021K PIK3CD mutation, thus increasing the spectrum of somatic mutations altering the PI3K signaling pathway in BL. Interestingly, this mutation is known to be associated with activated phosphoinositide 3-kinase delta syndrome (APDS). Finally, we also identified an inherited heterozygous truncating c.5791CT FANCM mutation that may contribute to the unusual recurrence of BL.

Published
2019

44. Myeloid malignancies with translocation t(4;12)(q11-13; p13): molecular landscape, clonal hierarchy and clinical outcomes.

Author

Parinet, Vincent, Chapiro, Elise, Bidet, Audrey, Gaillard, Baptiste, Maarek, Odile, Simon, Laurence, Lefebvre, Christine, Defasque, Sabine, Mozziconacci, Marie-Joelle, Quinquenel, Anne, Decamp, Matthieu, Lifermann, François, Ali-Ammar, Nadia, Maillon, Agathe, Baron, Marine, Martin, Mélanie, Struski, Stéphanie, Penther, Dominique, Micol, Jean-Baptiste, and Auger, Nathalie

Subjects
TREATMENT effectiveness, DYSPLASIA, ACUTE myeloid leukemia, SURVIVAL rate, MYELODYSPLASTIC syndromes, FLUORESCENCE in situ hybridization
Abstract

Translocation t(4;12)(q11-13; p13) is a recurrent but very rare chromosomal aberration in acute myeloid leukaemia (AML) resulting in the non-constant expression of a CHIC2/ETV6 fusion transcript. We report clinico-biological features, molecular characteristics and outcomes of 21 cases of t(4;12) including 19 AML and two myelodysplastic syndromes (MDS). Median age at the time of t(4;12) was 78 years (range, 56-88). Multilineage dysplasia was described in 10 of 19 (53%) AML cases and CD7 and/or CD56 expression in 90%. FISH analyses identified ETV6 and CHIC2 region rearrangements in respectively 18 of 18 and 15 of 17 studied cases. The t(4;12) was the sole cytogenetic abnormality in 48% of cases. The most frequent associated mutated genes were ASXL1 (n = 8/16, 50%), IDH1/2 (n = 7/16, 44%), SRSF2 (n = 5/16, 31%) and RUNX1 (n = 4/16, 25%). Interestingly, concurrent FISH and molecular analyses showed that t(4;12) can be, but not always, a founding oncogenic event. Median OS was 7.8 months for the entire cohort. In the 16 of 21 patients (76%) who received antitumoral treatment, overall response and first complete remission rates were 37% and 31%, respectively. Median progression-free survival in responders was 13.7 months. Finally, t(4;12) cases harboured many characteristics of AML with myelodysplasia-related changes (multilineage dysplasia, MDS-related cytogenetic abnormalities, frequent ASXL1 mutations) and a poor prognosis. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Light chain lambda myeloma with fatal AL cardiac amyloidosis in a 21‐year‐old patient: A case report and review

Author

Camus, Vincent, primary, Dubois, Sydney, additional, Thiébaut, Pierre‐Alain, additional, Lepretre, Stéphane, additional, Lenain, Pascal, additional, Picquenot, Jean‐Michel, additional, Veresezan, Elena‐Liana, additional, François, Arnaud, additional, Penther, Dominique, additional, Bauer, Fabrice, additional, Jaccard, Arnaud, additional, and Jardin, Fabrice, additional

Published
2019
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48. A recurrent clonally distinct Burkitt lymphoma case highlights genetic key events contributing to oncogenesis

Author

Penther, Dominique, primary, Viailly, Pierre‐Julien, additional, Latour, Sylvain, additional, Etancelin, Pascaline, additional, Bohers, Elodie, additional, Vellemans, Hélène, additional, Camus, Vincent, additional, Menard, Anne Lise, additional, Coutant, Sophie, additional, Lanic, Hélène, additional, Lemasle, Emilie, additional, Drieux, Fanny, additional, Veresezan, Liana, additional, Ruminy, Philippe, additional, Raimbault, Anna, additional, Soulier, Jean, additional, Frebourg, Thierry, additional, Tilly, Hervé, additional, and Jardin, Fabrice, additional

Published
2019
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49. The CADM1tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11

Author

Lafage-Pochitaloff, Marina, Gerby, Bastien, Baccini, Véronique, Largeaud, Laetitia, Fregona, Vincent, Prade, Naïs, Juvin, Pierre-Yves, Jamrog, Laura, Bories, Pierre, Hébrard, Sylvie, Lagarde, Stéphanie, Mansat-De Mas, Véronique, Dovey, Oliver M., Yusa, Kosuke, Vassiliou, George S., Jansen, Joop H., Tekath, Tobias, Rombaut, David, Ameye, Geneviève, Barin, Carole, Bidet, Audrey, Boudjarane, John, Collonge-Rame, Marie-Agnès, Gervais, Carine, Ittel, Antoine, Lefebvre, Christine, Luquet, Isabelle, Michaux, Lucienne, Nadal, Nathalie, Poirel, Hélène A., Radford-Weiss, Isabelle, Ribourtout, Bénédicte, Richebourg, Steven, Struski, Stéphanie, Terré, Christine, Tigaud, Isabelle, Penther, Dominique, Eclache, Virginie, Fontenay, Michaela, Broccardo, Cyril, and Delabesse, Eric

Abstract

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis leading to peripheral cytopenias and in a substantial proportion of cases to acute myeloid leukemia. The deletion of the long arm of chromosome 11, del(11q), is a rare but recurrent clonal event in MDS. Here, we detail the largest series of 113 cases of MDS and myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) harboring a del(11q) analyzed at clinical, cytological, cytogenetic, and molecular levels. Female predominance, a survival prognosis similar to other MDS, a low monocyte count, and dysmegakaryopoiesis were the specific clinical and cytological features of del(11q) MDS. In most cases, del(11q) was isolated, primary and interstitial encompassing the 11q22-23 region containing ATM, KMT2A, and CBLgenes. The common deleted region at 11q23.2 is centered on an intergenic region between CADM1(also known as Tumor Suppressor in Lung Cancer 1) and NXPE2. CADM1was expressed in all myeloid cells analyzed in contrast to NXPE2. At the functional level, the deletion of Cadm1 in murine Lineage-Sca1+Kit+cells modifies the lymphoid-to-myeloid ratio in bone marrow, although not altering their multilineage hematopoietic reconstitution potential after syngenic transplantation. Together with the frequent simultaneous deletions of KMT2A, ATM, and CBLand mutations of ASXL1, SF3B1, and CBL, we show that CADM1may be important in the physiopathology of the del(11q) MDS, extending its role as tumor-suppressor gene from solid tumors to hematopoietic malignancies.

Published
2022
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50. Poor prognosis of chromosome 7 clonal aberrations in Philadelphia-negative metaphases and relevance of potential underlying myelodysplastic features in chronic myeloid leukemia

Author

Bidet, Audrey, primary, Dulucq, Stéphanie, additional, Smol, Thomas, additional, Marceau-Renaut, Alice, additional, Morisset, Stéphane, additional, Coiteux, Valérie, additional, Noël-Walter, Marie-Pierre, additional, Nicolini, Franck-Emmanuel, additional, Tigaud, Isabelle, additional, Luquet, Isabelle, additional, Struski, Stéphanie, additional, Gaillard, Baptiste, additional, Penther, Dominique, additional, Tondeur, Sylvie, additional, Nadal, Nathalie, additional, Hermet, Eric, additional, Véronèse, Lauren, additional, Réa, Delphine, additional, Gervais, Carine, additional, Theisen, Olivier, additional, Terré, Christine, additional, Cony-Makhoul, Pascale, additional, Lefebvre, Christine, additional, Gaillard, Jean-Baptiste, additional, Radford, Isabelle, additional, Vervaeke, Anne-Laure, additional, Barin, Carole, additional, Chapiro, Elise, additional, Nguyen-Khac, Florence, additional, Etienne, Gabriel, additional, Preudhomme, Claude, additional, Mahon, François Xavier, additional, and Roche-Lestienne, Catherine, additional

Published
2018
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