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2. Recent Advances in the Management of Hormone-Sensitive Oligometastatic Prostate Cancer

Author

Marvaso G, Volpe S, Pepa M, Zaffaroni M, Corrao G, Augugliaro M, Nolè F, De Cobelli O, and Jereczek-Fossa BA

Subjects
oligometastatic prostate cancer, metastasis-directed therapies, narrative review, imaging, biology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Giulia Marvaso,1,2,* Stefania Volpe,1,2,* Matteo Pepa,1,* Mattia Zaffaroni,1,* Giulia Corrao,1,2,* Matteo Augugliaro,1,* Franco Nolè,3,* Ottavio De Cobelli,2,4,* Barbara Alicja Jereczek-Fossa1,2,* 1Division of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; 2Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy; 3Medical Oncology Division of Urogenital & Head & Neck Tumors, IEO European Institute of Oncology IRCCS, Milan, Italy; 4Department of Urology, IEO, European Institute of Oncology IRCCS, Milan, Italy*These authors contributed equally to this workCorrespondence: Matteo PepaDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Milan, ItalyEmail matteo.pepa@ieo.itAbstract: After primary treatment for prostate cancer with either radical prostatectomy or radiotherapy, a significant proportion of patients are at risk of developing metastases. In recent years, a deeper understanding of the underlying biology together with improved imaging techniques and the advent of new therapeutic options including metastases-directed therapies and new drugs have revolutionized the management of low-burden metastatic disease, also known as oligometastatic state. The purpose of this narrative review is to report the recent developments in the management of hormone-sensitive oligometastatic prostate cancer patients.Keywords: oligometastatic prostate cancer, metastasis-directed therapies, narrative review, imaging, biology

Published
2022

3. STRA-MI-VT (STereotactic RadioAblation by Multimodal Imaging for Ventricular Tachycardia): rationale and design of an Italian experimental prospective study

Author

Carbucicchio, C., Jereczek-Fossa, B. A., Andreini, D., Catto, V., Piperno, G., Conte, E., Cattani, F., Rondi, E., Vigorito, S., Piccolo, C., Bonomi, A., Gorini, A., Pepa, M., Mushtaq, S., Fassini, G., Moltrasio, M., Tundo, F., Marvaso, G., Veglia, F., Orecchia, R., Tremoli, E., and Tondo, C.

Published
2021
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7. DOSE-VOLUME CONSTRAINTS FOR RE-IRRADIATION OF PROSTATE CANCER RELAPSE

Author

Cambria, R., primary, Floriana, P., additional, Zerini, D., additional, Augugliaro, M., additional, Marvaso, G., additional, Pepa, M., additional, Rojas, D.P., additional, Colombo, F., additional, Bagnardi, V., additional, Frassoni, E., additional, Orecchia, R., additional, Jereczeck-Fossa, B.A., additional, and Cattani, F., additional

Published
2023
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9. Establishing a benchmark of diversity, equity, inclusion and workforce engagement in radiation oncology in Europe – An ESTRO collaborative project

Author

Gasnier, A, Jereczek-Fossa, B, Pepa, M, Bagnardi, V, Frassoni, S, Perryck, S, Spalek, M, Petit, S, Bertholet, J, Dubois, L, Franco, P, Gasnier A., Jereczek-Fossa B. A., Pepa M., Bagnardi V., Frassoni S., Perryck S., Spalek M., Petit S. F., Bertholet J., Dubois L. J., Franco P., Gasnier, A, Jereczek-Fossa, B, Pepa, M, Bagnardi, V, Frassoni, S, Perryck, S, Spalek, M, Petit, S, Bertholet, J, Dubois, L, Franco, P, Gasnier A., Jereczek-Fossa B. A., Pepa M., Bagnardi V., Frassoni S., Perryck S., Spalek M., Petit S. F., Bertholet J., Dubois L. J., and Franco P.

Abstract

Background and purpose: Diversity, Equity and Inclusion (DEI) in the medical workforce is linked to improved patient care and innovation, as well as employee retention and engagement. The European Society for Radiotherapy and Oncology launched a survey to provide a benchmark of DEI and engagement among radiation oncology (RO) professionals in Europe. Methods: An anonymous survey was disseminated among RO professionals in Europe. The survey collected demographics and professional information, and participants were asked if they felt they belonged to a minority group. A DEI and workforce engagement questionnaire by Person et al. evaluated 8 inclusion factors. A favourable score was calculated by adding the percentage of “strongly agreed” or “agreed” answers. Results: A total of 812 complete responses were received from 35 European countries. 21% of respondents felt they belonged to a minority group, mostly based on race/ethnicity (5.9%), nationality (4.8%) and age (4.3%). Compared to benchmark data from the United States, scores were lower for most inclusion factors, and to a greater extent for minority groups. The overall favourable score was 58% for those belonging to a minority group, significantly lower than for other respondents (71%, p < 0.001). Those belonging to a minority group because of their gender or age had the lowest overall favourable score (47% and 51% respectively). Conclusions: Our work indicates that actions to improve DEI and workforce engagement among RO professionals in Europe are urgently needed, in particular among minority groups. This would potentially improve employee wellbeing and retention, promoting high quality care and innovation.

Published
2022

10. Almost one year of COVID-19 pandemic: how radiotherapy centers have counteracted its impact on cancer treatment in Lombardy, Italy. CODRAL/AIRO-L study

Author

Jereczek-Fossa, B, Palazzi, M, Tonoli, S, Zaffaroni, M, Marvaso, G, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, De Stefani, A, Castiglioni, S, Catalano, G, Di Muzio, N, Cerrotta, A, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Massaro, P, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Barbonetti, C, Tortini, R, Valdagni, R, Vavassori, V, Pepa, M, Cazzaniga, L, Soatti, C, Jereczek-Fossa B. A., Palazzi M. F., Tonoli S., Zaffaroni M., Marvaso G., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., De Stefani A., Castiglioni S., Catalano G., Di Muzio N., Cerrotta A., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Massaro P., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Barbonetti C., Tortini R., Valdagni R., Vavassori V., Pepa M., Cazzaniga L. F., Soatti C. P., Jereczek-Fossa, B, Palazzi, M, Tonoli, S, Zaffaroni, M, Marvaso, G, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, De Stefani, A, Castiglioni, S, Catalano, G, Di Muzio, N, Cerrotta, A, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Massaro, P, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Barbonetti, C, Tortini, R, Valdagni, R, Vavassori, V, Pepa, M, Cazzaniga, L, Soatti, C, Jereczek-Fossa B. A., Palazzi M. F., Tonoli S., Zaffaroni M., Marvaso G., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., De Stefani A., Castiglioni S., Catalano G., Di Muzio N., Cerrotta A., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Massaro P., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Barbonetti C., Tortini R., Valdagni R., Vavassori V., Pepa M., Cazzaniga L. F., and Soatti C. P.

Abstract

Lombardy has represented the Italian and European epicenter of the coronavirus disease 2019 (COVID-19) pandemic. Although most clinical efforts within hospitals were diverted towards the care of virally infected patients, therapies for patients with cancer, including radiotherapy (RT), have continued. During both the first and second pandemic waves, several national and regional organizations provided Italian and Lombardian RT departments with detailed guidelines aimed at ensuring safe treatments during the pandemic. The spread of infection among patients and personnel was limited by adopting strict measures, including triage procedures, interpersonal distance, and adequate implementation of personal protective equipment (PPE). Screening procedures addressed to both the healthcare workforce and patients, such as periodic nasopharyngeal swabs, have allowed the early identification of asymptomatic or pauci-symptomatic COVID-19 cases, thus reducing the spread of the infection. Prevention of infection was deemed of paramount importance to protect both patients and personnel and to ensure the availability of a minimum number of staff members to maintain clinical activity. The choice of treating COVID-19–positive patients has represented a matter of debate, and the risk of oncologic progression has been weighted against the risk of infection of personnel and other patients. Such risk was minimized by creating dedicated paths, reserving time slots, applying intensified cleaning procedures, and supplying personnel and staff with appropriate PPE. Remote working of research staff, medical physicists, and, in some cases, radiation oncologists has prevented overcrowding of shared spaces, reducing infection spread.

Published
2022

11. PO-2112 Radiomics of diffusion-MRI for predicting Gleason Score in Prostate Cancer treated with radiotherapy

Author

Morelli, L., primary, Paganelli, C., additional, Marvaso, G., additional, Annunziata, S., additional, Parrella, G., additional, Pepa, M., additional, Zaffaroni, M., additional, Vicini, M.G., additional, Isaksson, L.J., additional, Corrao, G., additional, Pricolo, P., additional, Alessi, S., additional, Summers, P.E., additional, Cattani, F., additional, De Cobelli, O., additional, Orecchia, R., additional, Petralia, G., additional, Jereczek-Fossa, B.A., additional, and Baroni, G., additional

Published
2023
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12. MO-0558 Patients’ needs in Proton Therapy: a survey among 10 European Facilities

Author

Mazzola, G.C., primary, Bergamaschi, L., additional, Pedone, C., additional, Vincini, M.G., additional, Pepa, M., additional, Zaffaroni, M., additional, Volpe, S., additional, Doyen, J., additional, Fossati, P., additional, Haustermans, K., additional, Høyer, M., additional, Langendijk, J.A., additional, Matute, R., additional, Orlandi, E., additional, Rylander, H., additional, Rombi, B., additional, Troost, E., additional, Orecchia, R., additional, Alterio, D., additional, and Jereczek-Fossa, B.A., additional

Published
2023
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15. PO-1498 Stereotactic re-RT for local recurrence of PCa after primary surgery and RT: a retrospective study.

Author

Lorubbio, C., primary, Repetti, I., additional, Marvaso, G., additional, Corrao, G., additional, Pepa, M., additional, Zaffaroni, M., additional, Vincini, M.G., additional, Zerini, D., additional, Fodor, C., additional, Musi, G., additional, Petralia, G., additional, De Cobelli, O., additional, Cattani, F., additional, Orecchia, R., additional, and Jereczek-Fossa, B.A., additional

Published
2023
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16. PO-2108 Impact of breathing and image filtering on radiomic features derived from 4D-CT in early-STAGE NSCLC

Author

Volpe, S., primary, Mastroleo, F., additional, Gaeta, A., additional, Zaffaroni, M., additional, Pepa, M., additional, Vincini, M.G., additional, Raimondi, S., additional, Isaksson, L.J., additional, Rampinelli, C., additional, Cremonesi, M., additional, Gandini, S., additional, Guckenberger, M., additional, Orecchia, R., additional, and Jereczek-Fossa, B.A., additional

Published
2023
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17. Patients’ needs in Proton Therapy: a survey among 10 European Facilities

Author

Mazzola, G. C., Bergamaschi, L., Vincini, M., Pepa, M., Zaffaroni, M., Volpe, S., Rombi, B., Doyen, J., Fossati, P., Haustermans, K., Hoyer, M., Langendijk, H., Matute, R., Orlandi, E., Rylander, H., (0000-0001-9550-9050) Troost, E. G. C., Orecchia, R., Alterio, D., Jereczek-Fossa, B., Mazzola, G. C., Bergamaschi, L., Vincini, M., Pepa, M., Zaffaroni, M., Volpe, S., Rombi, B., Doyen, J., Fossati, P., Haustermans, K., Hoyer, M., Langendijk, H., Matute, R., Orlandi, E., Rylander, H., (0000-0001-9550-9050) Troost, E. G. C., Orecchia, R., Alterio, D., and Jereczek-Fossa, B.

Abstract

Aims: The number of Proton Therapy (PT) facilities is still limited worldwide, and the access to treatment could be characterized by patients’ logistic and economic challenges. Aim of the present survey is to assess the support provided to patients undergoing PT across Europe. Methods: Through a personnel contact, an online questionnaire (62 multiple-choice and open-ended questions) via Microsoft Forms was administered to 10 European PT centers. The questionnaire consisted of 62 questions divided into 6 sections: i) personal data; ii) general information on clinical activity; iii) fractionation, concurrent systemic treatments and technical aspects of PT facility; iv) indication to PT and reimbursement policies; v) economic and/ or logistic support to patients vi) participants agreement on statements related to the possible limitation of access to PT. A qualitative analysis was performed and reported. Results: From March to May 2022 all ten involved centers filled the survey. Nine centers treat from 100 to 500 patients per year. Paediatric patients accounted for 10–30%, 30–50% and 50–70% of the entire cohort for 7, 2 and 1 center, respectively. The most frequent tumours treated in adult population were brain tumours, sarcomas and head and neck carcinomas; in all centers, the mean duration of PT is longer than 3 weeks. In 80% of cases, the treatment reimbursement for PT is supplied by the respective country’s Health National System (HNS). HNS also provides economic support to patients in 70% of centers, while logistic and meal support is provided in 20% and 40% of centers, respectively. PT facilities offer economic and/or logistic support in 90% of the cases. Logistic support for parents of pediatric patients is provided by HNS only in one-third of centers. Overall, 70% of re- spondents agree that geographic challenges could limit a patient’s access to proton facilities and 60% believe that additional support should be given to patients referred for PT care.

Published
2023

21. High-performance prediction models for prostate cancer radiomics

Author

Isaksson, L.J., Repetto, M., Summers, P.E., Pepa, M., Zaffaroni, M., Vincini, M.G., Corrao, G., Mazzola, G.C., Rotondi, M., Bellerba, F., Raimondi, S., Haron, Z., Alessi, S., Pricolo, P., Mistretta, F.A., Luzzago, S., Cattani, F., Musi, G., De Cobelli, O., Cremonesi, M., Orecchia, R., La Torre, D., Marvaso, G., Petralia, G., and Jereczek-Fossa, B.A.

Subjects
Radiomics, Prostate cancer, Gradient boost, Deep learning, Settore MED/24 - Urologia
Published
2023

22. PO-2101 Added Value Of MRI Radiomics To Predict Pathological Status Of Prostate Cancer Patients

Author

Vincini, M.G, Marvaso, G., Isaksson, L.J, Zaffaroni, M., Pepa, M., Corrao, G., Summers, P.E., Repetto, M., Mazzola, G.C., Rotondi, M., Raimondi, S., Gandini, S., Volpe, S., Haron, Z., Alessi, S., Pricolo, P., Mistretta, F.A., Luzzago, S., Cattani, F., Musi, G., De Cobelli, O., Cremonesi, M., Orecchia, R., La Torre, D., Petralia, G., and Jereczek-Fossa, B.A.

Published
2023
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23. Finding safe dose-volume constraints for re-irradiation with SBRT of patients with prostate cancer relapse: The IEO experience

Author

Augugliaro, M, Marvaso, G, Cambria, R, Pepa, M, Bagnardi, V, Frassoni, S, Pansini, F, Patricia Rojas, D, Colombo, F, Iuliana Fodor, C, Musi, G, Petralia, G, De Cobelli, O, Cattani, F, Orecchia, R, Zerini, D, Alicja Jereczek-Fossa, B, Augugliaro M., Marvaso G., Cambria R., Pepa M., Bagnardi V., Frassoni S., Pansini F., Patricia Rojas D., Colombo F., Iuliana Fodor C., Musi G., Petralia G., De Cobelli O., Cattani F., Orecchia R., Zerini D., Alicja Jereczek-Fossa B., Augugliaro, M, Marvaso, G, Cambria, R, Pepa, M, Bagnardi, V, Frassoni, S, Pansini, F, Patricia Rojas, D, Colombo, F, Iuliana Fodor, C, Musi, G, Petralia, G, De Cobelli, O, Cattani, F, Orecchia, R, Zerini, D, Alicja Jereczek-Fossa, B, Augugliaro M., Marvaso G., Cambria R., Pepa M., Bagnardi V., Frassoni S., Pansini F., Patricia Rojas D., Colombo F., Iuliana Fodor C., Musi G., Petralia G., De Cobelli O., Cattani F., Orecchia R., Zerini D., and Alicja Jereczek-Fossa B.

Abstract

Aim: The primary aim of this study is to provide preliminary indications for safe constraints of rectum and bladder in patients re-irradiated with stereotactic body RT (SBRT). Methods: Data from patients treated for prostate cancer (PCa) and intraprostatic relapse, from 1998 to 2016, were retrospectively collected. First RT course was delivered with 3D conformal RT techniques, SBRT or volumetric modulated arc therapy (VMAT). All patients underwent re-irradiation with SBRT with heavy hypofractionated schedules. Cumulative dose-volume values to organs at risk (OARs) were computed and possible correlation with developed toxicities was investigated. Results: Twenty-six patients were included. Median age at re-irradiation was 75 years, mean interval between the two RT courses was 5.6 years and the median follow-up was 47.7 months (13.4–114.3 months). After re-irradiation, acute and late G ≥ 2 GU toxicity events were reported in 3 (12%) and 10 (38%) patients, respectively, while late G ≥ 2 GI events were reported in 4 (15%) patients. No acute G ≥ 2 GI side effects were registered. Patients receiving an equivalent uniform dose of the two RT treatments < 131 Gy appeared to be at higher risk of progression (4-yr b-PFS: 19% vs 33%, p = 0.145). Cumulative re-irradiation constraints that appear to be safe are D30% < 57.9 Gy for bladder and D30% < 66.0 Gy, D60% < 38.0 Gy and V122.1 Gy < 5% for rectum. Conclusion: Preliminary re-irradiation constraints for bladder and rectum have been reported. Our preliminary investigation may serve to clear some grey areas of PCa re-irradiation.

Published
2021

24. Salvage stereotactic body radiotherapy (SBRT) for intraprostatic relapse after prostate cancer radiotherapy: An ESTRO ACROP Delphi consensus

Author

Jereczek-Fossa, B, Marvaso, G, Zaffaroni, M, Gugliandolo, S, Zerini, D, Corso, F, Gandini, S, Alongi, F, Bossi, A, Cornford, P, De Bari, B, Fonteyne, V, Hoskin, P, Pieters, B, Tree, A, Arcangeli, S, Fuller, D, Franzese, C, Hannoun-Levi, J, Janoray, G, Kerkmeijer, L, Kwok, Y, Livi, L, Loi, M, Miralbell, R, Pasquier, D, Pinkawa, M, Scher, N, Scorsetti, M, Shelan, M, Toledano, A, van As, N, Vavassori, A, Zilli, T, Pepa, M, Ost, P, Jereczek-Fossa B. A., Marvaso G., Zaffaroni M., Gugliandolo S. G., Zerini D., Corso F., Gandini S., Alongi F., Bossi A., Cornford P., De Bari B., Fonteyne V., Hoskin P., Pieters B. R., Tree A. C., Arcangeli S., Fuller D. B., Franzese C., Hannoun-Levi J. -M., Janoray G., Kerkmeijer L., Kwok Y., Livi L., Loi M., Miralbell R., Pasquier D., Pinkawa M., Scher N., Scorsetti M., Shelan M., Toledano A., van As N., Vavassori A., Zilli T., Pepa M., Ost P., Jereczek-Fossa, B, Marvaso, G, Zaffaroni, M, Gugliandolo, S, Zerini, D, Corso, F, Gandini, S, Alongi, F, Bossi, A, Cornford, P, De Bari, B, Fonteyne, V, Hoskin, P, Pieters, B, Tree, A, Arcangeli, S, Fuller, D, Franzese, C, Hannoun-Levi, J, Janoray, G, Kerkmeijer, L, Kwok, Y, Livi, L, Loi, M, Miralbell, R, Pasquier, D, Pinkawa, M, Scher, N, Scorsetti, M, Shelan, M, Toledano, A, van As, N, Vavassori, A, Zilli, T, Pepa, M, Ost, P, Jereczek-Fossa B. A., Marvaso G., Zaffaroni M., Gugliandolo S. G., Zerini D., Corso F., Gandini S., Alongi F., Bossi A., Cornford P., De Bari B., Fonteyne V., Hoskin P., Pieters B. R., Tree A. C., Arcangeli S., Fuller D. B., Franzese C., Hannoun-Levi J. -M., Janoray G., Kerkmeijer L., Kwok Y., Livi L., Loi M., Miralbell R., Pasquier D., Pinkawa M., Scher N., Scorsetti M., Shelan M., Toledano A., van As N., Vavassori A., Zilli T., Pepa M., and Ost P.

Abstract

Background and purpose: Between 30% and 47% of patients treated with definitive radiotherapy (RT) for prostate cancer are at risk of intraprostatic recurrence during follow-up. Re-irradiation with stereotactic body RT (SBRT) is emerging as a feasible and safe therapeutic option. However, no consensus or guidelines exist on this topic. The purpose of this ESTRO ACROP project is to investigate expert opinion on salvage SBRT for intraprostatic relapse after RT. Materials and Methods: A 40-item questionnaire on salvage SBRT was prepared by an internal committee and reviewed by a panel of leading radiation oncologists plus a urologist expert in prostate cancer. Following the procedure of a Delphi consensus, 3 rounds of questionnaires were sent to selected experts on prostate re-irradiation. Results: Among the 33 contacted experts, 18 (54.5%) agreed to participate. At the end of the final round, participants were able to find consensus on 14 out of 40 questions (35% overall) and major agreement on 13 questions (32.5% overall). Specifically, the consensus was reached regarding some selection criteria (no age limit, ECOG 0–1, satisfactory urinary flow), diagnostic procedures (exclusion of metastatic disease, SBRT target defined on the MRI) and therapeutic approach (no need for concomitant ADT, consideration of the first RT dose, validity of Phoenix criteria for salvage SBRT failure). Conclusion: While awaiting the results of ongoing studies, our ESTRO ACROP Delphi consensus may serve as a practical guidance for salvage SBRT. Future research should address the existing disagreements on this promising approach.

Published
2021

25. Phantom study of stereotactic radioablation for ventricular tachycardia (STRA-MI-VT) using Cyberknife Synchrony Respiratory Tracking System with a single fiducial marker

Author

Piccolo, C., primary, Vigorito, S., additional, Rondi, E., additional, Piperno, G., additional, Ferrari, A., additional, Pepa, M., additional, Riva, G., additional, Durante, S., additional, Conte, E., additional, Catto, V., additional, Andreini, D., additional, Carbucicchio, C., additional, Jereczek-Fossa, B.A., additional, Pompilio, G., additional, Orecchia, R., additional, and Cattani, F., additional

Published
2022
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26. Back to (new) normality—A CODRAL/AIRO-L survey on cancer radiotherapy in Lombardy during Italian COVID-19 phase 2

Author

Jereczek-Fossa, B, Pepa, M, Marvaso, G, Isaksson, J, Soatti, C, Cazzaniga, L, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tortini, R, Valdagni, R, Vavassori, V, Tonoli, S, Palazzi, M, Jereczek-Fossa B. A., Pepa M., Marvaso G., Isaksson J. L., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tortini R., Valdagni R., Vavassori V., Tonoli S., Palazzi M. F., Jereczek-Fossa, B, Pepa, M, Marvaso, G, Isaksson, J, Soatti, C, Cazzaniga, L, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tortini, R, Valdagni, R, Vavassori, V, Tonoli, S, Palazzi, M, Jereczek-Fossa B. A., Pepa M., Marvaso G., Isaksson J. L., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tortini R., Valdagni R., Vavassori V., Tonoli S., and Palazzi M. F.

Abstract

Background: Italy experienced one of the world’s severest COVID-19 outbreak, with Lombardy being the most afflicted region. However, the imposed safety measures allowed to flatten the epidemic curve and hence to ease the restrictions and inaugurate, on the 4th of May 2020, the Italian phase (P) 2 of the pandemic. The present survey study, endorsed by CODRAL and AIRO-L, aimed to assess how radiotherapy (RT) departments in Lombardy have dealt with the recovery. Materials and methods: A questionnaire dealing with the management of pandemic was developed online and sent to all CODRAL Directors on the 10th of June 2020. Answers were collected in full anonymity one week after. Results: All the 33 contacted RT facilities (100%) responded to the survey. Despite the scale of the pandemic, during P1 14 (42.4%) centres managed to safely continue the activity (≤ 10% reduction). During P2, 10 (30.3%) centres fully recovered and 14 (42.4%) reported an increase. Nonetheless, 6 (18.2%) declared no changes and, interestingly, 3 (9.1%) reduced activities. Overall, 21 centres (63.6%) reported suspected or positive cases within healthcare workforce since the beginning of the pandemic. Staff units were quarantined in 19 (57.6%) and 6 (18.2%) centres throughout P1 and P2, respectively. In the two phases, about two thirds centres registered positive or suspected cases amongst patients. Conclusion: The study revealed a particular attention to anti-contagion measures and a return to normal or even higher clinical workload in most RT centres in Lombardy, necessary to carry out current and previously deferred treatments.

Published
2020

27. COVID-19 Outbreak and Cancer Radiotherapy Disruption in Lombardy, Northern Italy

Author

Jereczek-Fossa, B, Palazzi, M, Soatti, C, Cazzaniga, L, Ivaldi, G, Pepa, M, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Berlinghieri, S, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tonoli, S, Tortini, R, Valdagni, R, Vavassori, V, Marvaso, G, Jereczek-Fossa B. A., Palazzi M. F., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Pepa M., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Berlinghieri S., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tonoli S., Tortini R., Valdagni R., Vavassori V., Marvaso G., Jereczek-Fossa, B, Palazzi, M, Soatti, C, Cazzaniga, L, Ivaldi, G, Pepa, M, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Berlinghieri, S, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tonoli, S, Tortini, R, Valdagni, R, Vavassori, V, Marvaso, G, Jereczek-Fossa B. A., Palazzi M. F., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Pepa M., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Berlinghieri S., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tonoli S., Tortini R., Valdagni R., Vavassori V., and Marvaso G.

Published
2020

29. PO-1114 Intensity Modulated Radiotherapy (IMRT) after conservative surgery for supraglottic tumours

Author

Alterio, D., primary, Vigorito, S., additional, Emiro, F., additional, Vincini, M.G., additional, Ferrari, A., additional, Marani, S., additional, Pepa, M., additional, Zaffaroni, M., additional, Fodor, C., additional, Volpe, S., additional, Marvaso, G., additional, Bergamaschi, L., additional, Pedone, C., additional, Franzetti, J., additional, Zorzi, S., additional, Tagliabue, M., additional, Ansarin, M., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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30. PO-1482 Estimation of inter-fraction motion of pelvic organs in SBRT treatments of prostate oligometastases

Author

Pepa, M., primary, Corrao, G., additional, Morigi, G., additional, La Fauci, F.M., additional, Zaffaroni, M., additional, Vincini, M.G., additional, Augugliaro, M., additional, Mazzola, G.C., additional, Comi, S., additional, Mistretta, F.A., additional, Luzzago, S., additional, Gandini, S., additional, Musi, G., additional, Petralia, G., additional, De Cobelli, O., additional, Orecchia, R., additional, Cattani, F., additional, Marvaso, G., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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31. PO-1254 SBRT vs 3D-CRT FOR OLIGOMETASTATIC BONE NSCLC

Author

Marvaso, G., primary, Milovanova, E., additional, Santamaria, R., additional, Volpe, S., additional, Corrao, G., additional, Zaffaroni, M., additional, Pepa, M., additional, Vincini, M.G., additional, D'Ecclesiis, O., additional, Gandini, S., additional, Piperno, G., additional, Ferrari, A., additional, Orecchia, R., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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33. PO-1546 Dosimetric characterization of PLA 3D printed boluses for external beam radiotherapy

Author

Pepa, M., primary, Gugliandolo, S.G., additional, Pansini, F., additional, Vavassori, A., additional, Vincini, M.G., additional, Zaffaroni, M., additional, Alterio, D., additional, Rajendran, S., additional, Pillai, S.P., additional, Volpe, S., additional, Marvaso, G., additional, Corrao, G., additional, Cattani, F., additional, Colosimo, B.M., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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34. PO-1360 Nutritional and inflammatory status as predictive biomarkers in oligorecurrent PCa (RADIOSA TRIAL)

Author

Zaffaroni, M., primary, Marvaso, G., additional, Corrao, G., additional, Gandini, S., additional, Pepa, M., additional, Vincini, M.G., additional, Zerini, D., additional, Castronovo, F.M., additional, Augugliaro, M., additional, Cattani, F., additional, Mistretta, F.A., additional, Luzzago, S., additional, Musi, G., additional, Alessi, S., additional, Fodor, C., additional, Petralia, G., additional, Pravettoni, G., additional, De Cobelli, O., additional, Orecchia, R., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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35. PO-1772 Radiomic feature relevance in the prediction of pathological features of prostate cancer

Author

Isaksson, L.J., primary, Summers, P.E., additional, Pepa, M., additional, Zaffaroni, M., additional, Vincini, M.G., additional, Corrao, G., additional, Mazzola, G.C., additional, Rotondi, M., additional, Raimondi, S., additional, Gandini, S., additional, Volpe, S., additional, Haron, Z., additional, Alessi, S., additional, Pricolo, P., additional, Mistretta, F.A., additional, Luzzago, S., additional, Cattani, F., additional, Musi, G., additional, De Cobelli, O., additional, Cremonesi, M., additional, Orecchia, R., additional, Marvaso, G., additional, Petralia, G., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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36. MO-0551 Short-term RT for early PCa with concomitant boost to the DIL (phase II trial AIRC-IG-13218)-updates

Author

Corrao, G., primary, Marvaso, G., additional, Pepa, M., additional, Zaffaroni, M., additional, Vincini, M.G., additional, Bellerba, F., additional, Gandini, S., additional, Volpe, S., additional, Rojas, D.P., additional, Zerini, D., additional, Fodor, C.I., additional, Pricolo, P., additional, Alessi, S., additional, Petralia, G., additional, Mistretta, F.A., additional, Cambria, R., additional, Cattani, F., additional, De Cobelli, O., additional, Orecchia, R., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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37. PD-0412 Impact of adjuvant radiotherapy on biochemical recurrence rates for pn1 prostate cancer patients

Author

Corrao, G., primary, Marvaso, G., additional, Mistretta, F.A., additional, Luzzago, S., additional, Sabatini, I., additional, Di Trapani, E., additional, Cozzi, G., additional, Bianchi, R., additional, Ferro, M., additional, Matei, D.V., additional, Musi, G., additional, Pepa, M., additional, Zaffaroni, M., additional, Jereczek-Fossa, B.A., additional, and De Cobelli, O., additional

Published
2022
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40. MO-0385 Added value of MRI radiomics to predict pathological status of prostate cancer patients

Author

Marvaso, G., primary, Pepa, M., additional, Isaksson, L.J., additional, Summers, P.E., additional, Zaffaroni, M., additional, Vincini, M.G., additional, Corrao, G., additional, Mazzola, G.C., additional, Rotondi, M., additional, Raimondi, S., additional, Gandini, S., additional, Volpe, S., additional, Haron, Z., additional, Alessi, S., additional, Pricolo, P., additional, Mistretta, F.A., additional, Luzzago, S., additional, Cattani, F., additional, Musi, G., additional, De Cobelli, O., additional, Cremonesi, M., additional, Orecchia, R., additional, Petralia, G., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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41. PO-1190 Machine learning to predict locoregional relapse in pT1-2pN0-1 breast cancer following mastectomy

Author

Volpe, S., primary, Bellerba, F., additional, Zaffaroni, M., additional, Pepa, M., additional, Isaksson, L.J., additional, Maimone, G., additional, Menzani, B., additional, Monaco, I., additional, Maisonneuve, P., additional, Scognamiglio, I.R., additional, Dicuonzo, S., additional, Zerella, M.A., additional, Rojas, D.P., additional, Marvaso, G., additional, Fodor, C., additional, Gandini, S., additional, De Momi, E., additional, Veronesi, P., additional, Corso, G., additional, Galimberti, V.E., additional, Leonardi, M.C., additional, and Jereczek-Fossa, B.A., additional

Published
2022
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43. Campylobacter jejuni bacteremia in Italian pediatric patients with acute lymphoblastic leukemia: Report of two cases

Author

Martora F., Pagliuca C., Della Pepa M. E., Della Rocca M. T., Curto S., Iovene M. R., Vitiello M., Martora, F., Pagliuca, C., Della Pepa, M. E., Della Rocca, M. T., Curto, S., Iovene, M. R., and Vitiello, M.

Subjects
Campylobacter jejuni, acute lymphoblastic leukemia (ALL), bacteremia
Abstract

Infections caused by Campylobacter jejuni are rarely associated with extraintestinal complications. C. jejuni bacteremia is difficult to detect in patients with hematological malignancies undergoing chemotherapy where the choice of appropriate antibiotic treatment is extremely important. We report two cases of C. jejuni bacteremia in Italian pediatric patients affected by acute lymphoblastic leukemia (ALL). Agreeing with the most recent epidemiological data, both clinical isolates showed a typical phenotypic antimicrobial resistance patterns with combined resistance to ciprofloxacin and tetracycline. To our knowledge, this is the first report of C. jejuni isolation from the blood of ALL pediatric patients in Italy, and it provides important epidemiological information on this rare infection.

Published
2020

44. Salvage stereotactic external beam re-irradiation for prostate cancer local failure: finding safe dose constraints for principal organs at risk

Author

Cambria, R., primary, Zerini, D., additional, Pansini, F., additional, Rojas, D.P., additional, Pepa, M., additional, Colombo, F., additional, Marvaso, G., additional, Fodor, C.I., additional, Bagnardi, V., additional, Frassoni, S., additional, Cattani, F., additional, and Jereczek-Fossa, B.A., additional

Published
2021
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45. Evaluation of effect on dose due to displacement of bowel and target volume in SBRT treatment for oligorecurrent crastation sensitive prostate cancer patients

Author

la Fauci, F., primary, Marvaso, G., additional, Augugliaro, M., additional, Comi, S., additional, Pepa, M., additional, Zaffaroni, M., additional, Corrao, G., additional, Mistretta, F.A., additional, Gandini, S., additional, Petralia, G., additional, Cattani, F., additional, de Cobelli, O., additional, Orecchia, R., additional, and Jereczek-Fossa, B., additional

Published
2021
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46. Comparison of automated segmentation techniques for magnetic resonance images of the prostate

Author

Pepa, M., primary, Isaksson, J. Lars, additional, Zaffaroni, M., additional, Summers, P.E., additional, Marvaso, G., additional, Raimondi, S., additional, Gandini, S., additional, Volpe, S., additional, Rojas, D.P., additional, Zerini, D., additional, Haron, Z., additional, Pricolo, P., additional, Alessi, S., additional, Mistretta, F.A., additional, Luzzago, S., additional, Cattani, F., additional, De Cobelli, O., additional, Cassano, E., additional, Cremonesi, M., additional, Bellomi, M., additional, Orecchia, R., additional, Petralia, G., additional, and Jereczek-Fossa, B.A., additional

Published
2021
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47. Phantom study of stereotactic radioablation treatments for ventricular tachycardia (STRA-MI-VT) using Cyberknife synchrony respiratory tracking system with a single fiducial marker

Author

Piccolo, C., primary, Vigorito, S., additional, Rondi, E., additional, Piperno, G., additional, Ferrari, A., additional, Pepa, M., additional, Conte, E., additional, Catto, V., additional, Andreini, D., additional, Carbucicchio, C., additional, Jereczek-Fossa, B., additional, and Cattani, F., additional

Published
2021
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48. PO-1344 Preliminary results of Phase II trial on Carbon-ion boost followed by IMRT for high risk PCa

Author

Patti, F., primary, Marvaso, G., additional, Pepa, M., additional, Vischioni, B., additional, Zaffaroni, M., additional, Comi, S., additional, Zerini, D., additional, Augugliaro, M., additional, Russo, S., additional, Valvo, F., additional, Giandini, T., additional, Avuzzi, B., additional, Valdagni, R., additional, De Cobelli, O., additional, Cattani, F., additional, Orlandi, E., additional, Jereczek-Fossa, B.A., additional, and Orecchia, R., additional

Published
2021
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49. PH-0604 Hippocampal Sparing WBRT: Trade-Off Between Tumor Control And Quality Of Life? A series of 150 pts

Author

Corrao, G., primary, Bergamaschi, L., additional, Pierini, V.E., additional, Ferrari, A., additional, Piperno, G., additional, Marvaso, G., additional, Riva, G., additional, Cavallo, I., additional, Emiro, F., additional, Pepa, M., additional, Zaffaroni, M., additional, Gandini, S., additional, Leonardi, M.C., additional, Cattani, F., additional, Orecchia, R., additional, and Jereczek-Fossa, B.A., additional

Published
2021
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