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286 results on '"Pequignot, Jean-Marc"'

5. Chemosensory Inputs and Neural Remodeling in Carotid Body and Brainstem Catecholaminergic Cells

Author

Soulage, Christophe, Pascual, Olivier, Roux, Jean-Christophe, Denavit-Saubié, Monique, Pequignot, Jean-Marc, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Champagnat, Jean, editor, Denavit-Saubié, Monique, editor, Fortin, Gilles, editor, Foutz, Arthur S., editor, and Thoby-Brisson, Muriel, editor

Published
2005
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15. Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats

Author

Joseph, Vincent, Soliz, Jorge, Soria, Ruddy, Pequignot, Jacqueline, Favier, Roland, Spielvogel, Hilde, and Pequignot, Jean Marc

Subjects
Dopaminergic mechanisms -- Physiological aspects, Carotid body -- Physiological aspects, Ovariectomy -- Influence, Postmenopausal women -- Physiological aspects, Mountain sickness -- Physiological aspects, Hypoxia -- Physiological aspects, Biological sciences
Abstract

We tested the hypothesis that ovarian steroids stimulate breathing through a dopaminergic mechanism in the carotid bodies. In ovariectomized female rats raised at sea level, domperidone, a peripheral [D.sub.2]-receptor antagonist, increased ventilation in normoxia (minute ventilation = +55%) and acute hypoxia (+32%). This effect disappeared after 10 daily injections of ovarian steroids (progesterone + estradiol). At high altitude (3,600 m, Bolivian Institute for High-Altitude Biology-IBBA, La Paz, Bolivia), neutered females had higher carotid body tyrosine hydroxylase activity (the rate-limiting enzyme for catecholamine synthesis: +129%) and dopamine utilization (+150%), lower minute ventilation (-30%) and hypoxic ventilatory response (-57%), and higher hematocrit (+18%) and Hb concentration (+21%) than intact female rats. Consistent signs of arterial pulmonary hypertension (right ventricular hypertrophy) also appeared in ovariectomized females. None of these parameters was affected by gonadectomy in males. Our results show that ovarian steroids stimulate breathing by lowering a peripheral dopaminergic inhibitory drive. This process may partially explain the deacclimatization of post-menopausal women at high altitude. hypoxia; ovarian steroids; chronic mountain sickness

Published
2002

23. Relationships among training stress, mood and dehydroepiandrosterone sulphate/cortisol ratio in female cyclists

Author

Bouget, Mikael, Rouveix, Mathieu, Michaux, Odile, Pequignot, Jean-Marc, and Filaire, Edith

Subjects
Cyclists -- Training, Cyclists -- Physiological aspects, Cyclists -- Research, Hydrocortisone -- Dosage and administration, Hydrocortisone -- Research, Women athletes -- Psychological aspects, Dehydroepiandrosterone -- Research, Dehydroepiandrosterone -- Dosage and administration
Published
2006

32. Norepinephrine content in discrete brain areas and neurohypophysial vasopressin in rats after a 9-d spaceflight (SLS-1)

Author

Fareh, Jeannette, Cottet-Emard, Jean-Marie, Pequignot, Jean-Marc, Jahns, Gary, Meylor, John, Viso, Michel, Vassaux, Didier, Gauquelin, Guillemette, and Gharib, Claude

Subjects
Life Sciences (General)
Abstract

The norepinephrine (NE) content in discrete brain areas and the vasopressin content in the neurohypophysial system were assessed in rats after a 9-d spaceflight and after a recovery period. The NE content in the locus coeruleus decreased significantly in spaceflight rats, but showed no difference between control and flight animals after a 9-d recovery. These findings were probably due to an acute stress undergone during landing. The NE content was unchanged in the A2 and A5 cell groups. In rats flown aboard SLS-1, the vasopressin content was increased in the posterior pituitary, and was significantly decreased in the hypothalamus. We conclude that the NE depletion in the locus coeruleus and the alteration in vasopressin release were consistent with an acute stress, likely occurring during and/or after landing. These changes tend to mask the actual neuroendocrine modifications caused by microgravity.

Published
1993

37. Protein translocation into dendrites: implication of glia-derived angiotensins in noradrenergic brainstem neurons

Author

Ogier, Michaël, Bricca, Giampiero, Navarro, Fabrice, Pequignot, Jean-Marc, Morales, Anne, Bezin, Laurent, and Cohen-Adad, Frédérique

Subjects
nervous system, ontogeny, tyrosine hydroxylase, [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], angiotensins, gene expression, dendritic trafficking, Transgenic rats
Abstract

Noradrenaline (NA) released by dendrites of locus coeruleus (LC) neurons controls LC neuron activity, and hence, NA released from noradrenergic fibers in terminal fields. NA synthesis is dependent on tyrosine hydroxylase (TH), whose dendritic presence is controlled precisely in LC neurons during postnatal development. However, the mechanisms controlling specifically dendritic sorting of TH without affecting its axonal transport remained to be elucidated. Here, by using transgenic rats with astrocyte-directed depletion of angiotensinogen, we show that dendritic but not axonal TH protein sorting is initiated after weaning by cerebral angiotensins in LC neurons, but not in dopaminergic neurons of the substantia nigra (SN). Cerebral angiotensins trigger dendritic translocation of TH protein by stimulating phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS), known to facilitate macromolecule export from the soma. Protein trafficking within either axons or dendrites of LC neurons is thus controlled by specialized mechanisms, some having a glial origin.

Published
2006

38. Repeated prolonged exercise during four days increases sleeping heart rate and metabolic rate

Author

Mischler, Isabelle, Vermorel, Michel, Montaurier, Christophe, Mounier, Rémi, Pialoux, Vincent, Pequignot, Jean-Marc, Cottet-Emard, Jean Marie, Coudert, Jean, Fellmann, Nicole, Laboratoire de Physiologie-Biologie du Sport, Université d'Auvergne - Clermont-Ferrand I (UdA), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Physiologie intégrative, cellulaire et moléculaire (PICM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), ProdInra, Archive Ouverte, Université d'Auvergne - Clermont-Ferrand I ( UdA ), Unité de Nutrition Humaine - Clermont Auvergne ( UNH ), Université Clermont Auvergne ( UCA ) -Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] ( INRA Auvergne/Rhône-Alpes ), Physiologie intégrative, cellulaire et moléculaire ( PICM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon

Subjects
[SDV] Life Sciences [q-bio], pulse rate, [ SDV ] Life Sciences [q-bio], physical exercise, [SDV]Life Sciences [q-bio], human activities, fréquence cardiaque, activité physique
Abstract

Repeated prolonged exercise during four days increases sleeping heart rate and metabolic rate. 8. Annual Congress of the European College of Sport Science

Published
2003

42. Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis

Author

Morales, Anne, primary, Bonnet, Chantal, additional, Bourgoin, Naïck, additional, Touvier, Thierry, additional, Nadam, Jérémie, additional, Laglaine, Aël, additional, Navarro, Fabrice, additional, Moulin, Colette, additional, Georges, Béatrice, additional, Pequignot, Jean-Marc, additional, and Bezin, Laurent, additional

Published
2006
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