1. Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
- Author
-
Müller Claudia Regina, Haas Sandra Elisa, Bassani Valquíria Linck, Guterres Sílvia Stanisçuaski, Fessi Hatem, Peralba Maria do Carmo R., and Pohlmann Adriana Raffin
- Subjects
nanoparticles ,diclofenac ,degradation ,Chemistry ,QD1-999 - Abstract
The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2',6'-dichlorophenyl)aminobenzyl alcohol and N-(2',6'-dichlorophenyl)anthranilylaldehyde.
- Published
- 2004