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1. Real-world data: Call for paradigm shift towards neoadjuvant chemotherapy in patients with upper tract urothelial carcinoma treated with nephroureterectomy - analysis of the ROBUUST registry

Author

Tuderti, G., primary, Proietti, F., additional, Wu, Z., additional, Franco, A., additional, Abdollah, F., additional, Finati, M., additional, Ferro, M., additional, Tozzi, M., additional, Porpiglia, F., additional, Checcucci, E., additional, Margulis, V., additional, Singla, N., additional, Derweesh, I.H., additional, Correa, A., additional, Gonzalgo, M.L., additional, Mehrazin, R., additional, Sundaram, C.P., additional, Tufano, A., additional, Perdonà, S., additional, Djaladat, H., additional, Ditonno, F., additional, Antonelli, A., additional, Autorino, R., additional, and Simone, G., additional

Published
2024
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2. Comparing functional outcomes between active surveillance vs. radical prostatectomy as initial approach in newly diagnosis ISUP 1 prostate cancer

Author

Flammia, R.S., primary, Luzzago, S., additional, Brassetti, A., additional, Mistretta, F.A., additional, Musi, G., additional, Salvador, M., additional, Brunocilla, E., additional, Droghetti, M., additional, Manfredi, M., additional, De Luca, S., additional, Porpiglia, F., additional, Tufano, A., additional, Passaro, F., additional, Perdonà, S., additional, Cormio, A., additional, Chiacchio, G., additional, Galosi, A.B., additional, Scarcia, M., additional, Ludovico, G.M., additional, Cormio, L., additional, De Cobelli, O., additional, Schiavina, R., additional, Leonardo, C., additional, and Simone, G., additional

Published
2024
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3. Real-world management of high-risk upper tract urothelial carcinoma: Level of adherence to EAU guidelines - analysis of the ROBUUST registry

Author

Tuderti, G., primary, Proietti, F., additional, Wu, Z., additional, Franco, A., additional, Abdollah, F., additional, Finati, M., additional, Ferro, M., additional, Tozzi, M., additional, Porpiglia, F., additional, Checcucci, E., additional, Margulis, V., additional, Singla, N., additional, Derweesh, I.H., additional, Correa, A., additional, Gonzalgo, M.L., additional, Mehrazin, R., additional, Sundaram, C.P., additional, Tufano, A., additional, Perdonà, S., additional, Djaladat, H., additional, Ditonno, F., additional, Antonelli, A., additional, Autorino, R., additional, and Simone, G., additional

Published
2024
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5. Decisional and prognostic impact of diagnostic ureteroscopy in high-risk upper tract urothelial carcinoma: A multi-institutional collaborative analysis (ROBUUST collaborative group)

Author

Ditonno, F., primary, Veccia, A., additional, Montanaro, F., additional, Pettenuzzo, G., additional, Costantino, S., additional, Franco, A., additional, Wu, Z., additional, Correa, A., additional, Margulis, V., additional, Djaladat, H., additional, Simone, G., additional, Derweesh, I.H., additional, Abdollah, F., additional, Nirmish, S., additional, Ferro, M., additional, Porpiglia, F., additional, Checcucci, E., additional, Gonzalgo, M.L., additional, Perdonà, S., additional, Mehrazin, R., additional, Sundaram, C.P., additional, Autorino, R., additional, and Antonelli, A., additional

Published
2024
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6. Progression-free survival as surrogate endpoint in high-risk non-muscle invasive bladder cancer studies: results from a machine learning-based analysis of a large multi-institutional database

Author

Marchioni, M., primary, Porreca, A., additional, Di Nicola, M., additional, Lucarelli, G., additional, Dorin, V.M., additional, Soria, F., additional, Terracciano, D., additional, Mistretta, F.A., additional, Buonerba, C., additional, Cantiello, F., additional, Mari, A., additional, Minervini, A., additional, Veccia, A., additional, Musi, G., additional, Hurle, R., additional, Busetto, G.M., additional, Del Giudice, F., additional, Chung, B.I., additional, Berardinelli, F., additional, Perdonà, S., additional, Del Prete, P., additional, Mirone, V., additional, Borghesi, M., additional, Bove, P., additional, Autorino, R., additional, Crisan, N., additional, Battaglia, M., additional, Ditonno, P., additional, Russo, G.I., additional, Muto, M., additional, Damiano, R., additional, Porpiglia, F., additional, de Cobelli, O., additional, Schips, L., additional, and Ferro, M., additional

Published
2022
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7. On-clamp versus off-clamp robotic partial nephrectomy for totally endophytic “deep” renal masses: propensity score-matched comparison of perioperative, oncologic and functional outcomes of a multicenter analysis (rosula database)

Author

Tuderti, G., primary, Autorino, R., additional, Minervini, A., additional, Kaouk, J., additional, Lau, C., additional, Perdonà, S., additional, Porpiglia, F., additional, Derweesh, I., additional, Carbonara, U., additional, Rha, K.H., additional, Schiavina, R., additional, Mastroianni, R., additional, Misuraca, L., additional, Mari, A., additional, Brassetti, A., additional, Anceschi, U., additional, Bove, A., additional, Ferriero, M., additional, Mottrie, A., additional, Gallucci, M., additional, and Simone, G., additional

Published
2022
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8. A0334 - On-clamp versus off-clamp robotic partial nephrectomy for totally endophytic deep renal masses: Propensity score-matched comparison of perioperative, oncologic and functional outcomes of a multicenter analysis (ROSULA database)

Author

Tuderti, G., Autorino, R., Minervini, A., Kaouk, J., Lau, C., Perdonà, S., Porpiglia, F., Derweesh, I., Saidian, A., Nguyen, M., Carbonara, U., Rha, K.H., Schiavina, R., Mastroianni, R., Misuraca, L., Mari, A., Brassetti, A., Anceschi, U., Bove, A., Ferriero, M., Mottrie, A., Gallucci, M., and Simone, G.

Published
2022
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9. A0819 - Comparing functional outcomes between active surveillance vs. radical prostatectomy as initial approach in newly diagnosis ISUP 1 prostate cancer

Author

Flammia, R.S., Luzzago, S., Brassetti, A., Mistretta, F.A., Musi, G., Salvador, M., Brunocilla, E., Droghetti, M., Manfredi, M., De Luca, S., Porpiglia, F., Tufano, A., Passaro, F., Perdonà, S., Cormio, A., Chiacchio, G., Galosi, A.B., Scarcia, M., Ludovico, G.M., Cormio, L., De Cobelli, O., Schiavina, R., Leonardo, C., and Simone, G.

Published
2024
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10. A0104 - Robotic distal ureterectomy for high-risk distal ureteral urothelial carcinoma: A retrospective multicenter comparative analysis (ROBUUST collaborative analysis)

Author

Ditonno, F., Franco, A., Wu, Z., Wang, L., Correa, A., Margulis, V., Djaladat, H., Veccia, A., Simone, G., Tuderti, G., Derweesh, I.H., Abdollah, F., Singla, N., Ferro, M., Porpiglia, F., Checcucci, E., Amparore, D., Gonzalgo, M.L., Perdonà, S., Tufano, A., Mehrazin, R., Sundaram, C.P., Antonelli, A., and Autorino, R.

Published
2024
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11. A0091 - Real-world management of high-risk upper tract urothelial carcinoma: Level of adherence to EAU guidelines - analysis of the ROBUUST registry

Author

Tuderti, G., Proietti, F., Wu, Z., Franco, A., Abdollah, F., Finati, M., Ferro, M., Tozzi, M., Porpiglia, F., Checcucci, E., Margulis, V., Singla, N., Derweesh, I.H., Correa, A., Gonzalgo, M.L., Mehrazin, R., Sundaram, C.P., Tufano, A., Perdonà, S., Djaladat, H., Ditonno, F., Antonelli, A., Autorino, R., and Simone, G.

Published
2024
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12. A0090 - Real-world data: Call for paradigm shift towards neoadjuvant chemotherapy in patients with upper tract urothelial carcinoma treated with nephroureterectomy - analysis of the ROBUUST registry

Author

Tuderti, G., Proietti, F., Wu, Z., Franco, A., Abdollah, F., Finati, M., Ferro, M., Tozzi, M., Porpiglia, F., Checcucci, E., Margulis, V., Singla, N., Derweesh, I.H., Correa, A., Gonzalgo, M.L., Mehrazin, R., Sundaram, C.P., Tufano, A., Perdonà, S., Djaladat, H., Ditonno, F., Antonelli, A., Autorino, R., and Simone, G.

Published
2024
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13. A0029 - Decisional and prognostic impact of diagnostic ureteroscopy in high-risk upper tract urothelial carcinoma: A multi-institutional collaborative analysis (ROBUUST collaborative group)

Author

Ditonno, F., Veccia, A., Montanaro, F., Pettenuzzo, G., Costantino, S., Franco, A., Wu, Z., Correa, A., Margulis, V., Djaladat, H., Simone, G., Derweesh, I.H., Abdollah, F., Nirmish, S., Ferro, M., Porpiglia, F., Checcucci, E., Gonzalgo, M.L., Perdonà, S., Mehrazin, R., Sundaram, C.P., Autorino, R., and Antonelli, A.

Published
2024
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15. Renal function deterioration assessment in totally endophytic “deep” renal masses treated with robotic partial nephrectomy: comparison with a whole cohort of cT1-2 renal tumors patients from a multicenter analysis (ROSULA database)

Author

Tuderti, G., primary, Autorino, R., additional, Carbonara, U., additional, Mari, A., additional, Amparore, D., additional, Mastroianni, R., additional, Bove, A.M., additional, Anceschi, U., additional, Perdonà, S., additional, Lau, C., additional, Koon, H.R., additional, Leonardo, C., additional, Misuraca, L., additional, Ferriero, M., additional, Brassetti, A., additional, Schiavina, R., additional, Derweesh, I., additional, Porpiglia, F., additional, Mottrie, A., additional, Kaouk, J., additional, Minervini, A., additional, and Simone, G., additional

Published
2021
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16. Robotic partial nephrectomy for totally endophytic “deep” renal masses: perioperative, pathologic, oncologic and functional outcomes of a multicenter analysis (ROSULA database)

Author

Misuraca, L., primary, Tuderti, G., additional, Autorino, R., additional, Carbonara, U., additional, Mari, A., additional, Amparore, D., additional, Mastroianni, R., additional, Bove, A.M., additional, Anceschi, U., additional, Ferriero, M., additional, Brassetti, A., additional, Perdonà, S., additional, Lau, C., additional, Koon, H.R., additional, Leonardo, C., additional, Schiavina, R., additional, Derweesh, I., additional, Porpiglia, F., additional, Mottrie, A., additional, Kaouk, J., additional, Minervini, A., additional, and Simone, G., additional

Published
2021
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17. Trifecta assessment in totally endophytic “deep” renal masses treated with robotic partial nephrectomy: comparison with a whole cohort of cT1-2 renal tumors patients from a multicenter analysis (ROSULA database)

Author

Tuderti, G., primary, Autorino, R., additional, Carbonara, U., additional, Mari, A., additional, Amparore, D., additional, Mastroianni, R., additional, Bove, A.M., additional, Anceschi, U., additional, Misuraca, L., additional, Ferriero, M., additional, Brassetti, A., additional, Perdonà, S., additional, Lau, C., additional, Koon, H.R., additional, Leonardo, C., additional, Schiavina, R., additional, Derweesh, I., additional, Porpiglia, F., additional, Mottrie, A., additional, Kaouk, J., additional, Minervini, A., additional, and Simone, G., additional

Published
2021
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19. Nephrometry scores predicting value of trifecta achievement in a multicenter analysis (ROSULA database) of robotic partial nephrectomy for totally endophytic “deep” renal masses

Author

Misuraca, L., primary, Tuderti, G., additional, Autorino, R., additional, Carbonara, U., additional, Mari, A., additional, Amparore, D., additional, Mastroianni, R., additional, Bove, A.M., additional, Anceschi, U., additional, Ferriero, M., additional, Brassetti, A., additional, Perdonà, S., additional, Lau, C., additional, Koon, H.R., additional, Leonardo, C., additional, Schiavina, R., additional, Derweesh, I., additional, Porpiglia, F., additional, Mottrie, A., additional, Kaouk, J., additional, Minervini, A., additional, and Simone, G., additional

Published
2021
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23. Management of Oncological Urological Surgery Cases During the Covid-19 Epidemic. The Real Life Experince of A Oncological Terziary High Volume Center

Author

Rossetti S, Cascella M, L. Castaldo, Pignata S, A. Izzo, Perdonà S, Grimaldi G, De Sicato S, Cuomo M, Quarto G, Raffaele Muscariello, and Frazese D

Subjects
medicine.medical_specialty, business.industry, General surgery, Urinary system, Psychological intervention, Cancer, Context (language use), medicine.disease, medicine, Penile cancer, Robotic surgery, business, Kidney cancer, Testicular cancer
Abstract

Aim: The COVID-19 has dramatically stressed the Italian health system. The management of cancers of the urinary and male genital tracts must be adapted to this context. Material and Method: were analysed operator data of cancer patients treated during outbreaks. Results: The medical and surgical management of patients with any cancers of the urinary and male genital tracts must be adapted by modifying the consultation methods, by prioritizing interventions according to the intrinsic prognosis of cancers, taking into account the patient's comorbidities. The protection of urologists from COVID-19 must be considered. Conclusion: Our study shows that with due precautions and with the right patient choice, urological surgical procedures can also be performed during the covid period and that robotic surgery is preferable as a therapeutic choice.

Published
2020
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25. SC221 - Progression-free survival as surrogate endpoint in high-risk non-muscle invasive bladder cancer studies: results from a machine learning-based analysis of a large multi-institutional database

Author

Marchioni, M., Porreca, A., Di Nicola, M., Lucarelli, G., Dorin, V.M., Soria, F., Terracciano, D., Mistretta, F.A., Buonerba, C., Cantiello, F., Mari, A., Minervini, A., Veccia, A., Musi, G., Hurle, R., Busetto, G.M., Del Giudice, F., Chung, B.I., Berardinelli, F., Perdonà, S., Del Prete, P., Mirone, V., Borghesi, M., Bove, P., Autorino, R., Crisan, N., Battaglia, M., Ditonno, P., Russo, G.I., Muto, M., Damiano, R., Porpiglia, F., de Cobelli, O., Schips, L., and Ferro, M.

Published
2022
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26. SC192 - On-clamp versus off-clamp robotic partial nephrectomy for totally endophytic “deep” renal masses: propensity score-matched comparison of perioperative, oncologic and functional outcomes of a multicenter analysis (rosula database)

Author

Tuderti, G., Autorino, R., Minervini, A., Kaouk, J., Lau, C., Perdonà, S., Porpiglia, F., Derweesh, I., Carbonara, U., Rha, K.H., Schiavina, R., Mastroianni, R., Misuraca, L., Mari, A., Brassetti, A., Anceschi, U., Bove, A., Ferriero, M., Mottrie, A., Gallucci, M., and Simone, G.

Published
2022
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29. SC64 - Robotic partial nephrectomy for totally endophytic “deep” renal masses: perioperative, pathologic, oncologic and functional outcomes of a multicenter analysis (ROSULA database)

Author

Misuraca, L., Tuderti, G., Autorino, R., Carbonara, U., Mari, A., Amparore, D., Mastroianni, R., Bove, A.M., Anceschi, U., Ferriero, M., Brassetti, A., Perdonà, S., Lau, C., Koon, H.R., Leonardo, C., Schiavina, R., Derweesh, I., Porpiglia, F., Mottrie, A., Kaouk, J., Minervini, A., and Simone, G.

Published
2021
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30. SC63 - Trifecta assessment in totally endophytic “deep” renal masses treated with robotic partial nephrectomy: comparison with a whole cohort of cT1-2 renal tumors patients from a multicenter analysis (ROSULA database)

Author

Tuderti, G., Autorino, R., Carbonara, U., Mari, A., Amparore, D., Mastroianni, R., Bove, A.M., Anceschi, U., Misuraca, L., Ferriero, M., Brassetti, A., Perdonà, S., Lau, C., Koon, H.R., Leonardo, C., Schiavina, R., Derweesh, I., Porpiglia, F., Mottrie, A., Kaouk, J., Minervini, A., and Simone, G.

Published
2021
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31. SC62 - Renal function deterioration assessment in totally endophytic “deep” renal masses treated with robotic partial nephrectomy: comparison with a whole cohort of cT1-2 renal tumors patients from a multicenter analysis (ROSULA database)

Author

Tuderti, G., Autorino, R., Carbonara, U., Mari, A., Amparore, D., Mastroianni, R., Bove, A.M., Anceschi, U., Perdonà, S., Lau, C., Koon, H.R., Leonardo, C., Misuraca, L., Ferriero, M., Brassetti, A., Schiavina, R., Derweesh, I., Porpiglia, F., Mottrie, A., Kaouk, J., Minervini, A., and Simone, G.

Published
2021
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32. SC43 - Nephrometry scores predicting value of trifecta achievement in a multicenter analysis (ROSULA database) of robotic partial nephrectomy for totally endophytic “deep” renal masses

Author

Misuraca, L., Tuderti, G., Autorino, R., Carbonara, U., Mari, A., Amparore, D., Mastroianni, R., Bove, A.M., Anceschi, U., Ferriero, M., Brassetti, A., Perdonà, S., Lau, C., Koon, H.R., Leonardo, C., Schiavina, R., Derweesh, I., Porpiglia, F., Mottrie, A., Kaouk, J., Minervini, A., and Simone, G.

Published
2021
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33. P0577 - Renal function deterioration assessment in totally endophytic “deep” renal masses treated with robotic partial nephrectomy: Comparison with a whole cohort of cT1-2 renal tumors patients from a multicenter analysis (ROSULA database)

Author

Tuderti, G., Autorino, R., Carbonara, U., Mari, A., Amparore, D., Di Maida, F., Beksac, A.T., Mastroianni, R., Bove, A., Anceschi, U., Franzese, D., Rosiello, G., Bianchi, L., Koukourikis, P., Perdonà, S., Lau, C., Koon, H.R., Leonardo, C., Schiavina, R., Derweesh, I., Porpiglia, F., Alexandre, M., Kaouk, J., Minervini, A., and Simone, G.

Published
2021
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35. Minimally invasive partial nephrectomy for elderly patients with renal mass: Morbidity, renal function and oncologic outcomes in the resurge collaborative database

Author

Larcher, A., primary, Capitanio, U., additional, Muttin, F., additional, Antonelli, A., additional, Palumbo, C., additional, Furlan, M., additional, Pavan, N., additional, Trombetta, C., additional, Silvestri, T., additional, Mir, C., additional, Breda, A., additional, Palou, J., additional, Rodriguez Faba, O., additional, Linares, E., additional, Aguilera, A., additional, Takagi, T., additional, Tanabe, K., additional, Porpiglia, F., additional, Bertolo, R., additional, Rha, K., additional, Raheem, A., additional, Maurer, T., additional, Amiel, T., additional, Yang, B., additional, Zang, C., additional, De Naeyer, G., additional, Mottrie, A., additional, Long, J., additional, Fiard, G., additional, De Nunzio, C., additional, Tubaro, A., additional, Ferro, M., additional, de Cobelli, O., additional, Micali, S., additional, Bevilacqua, L., additional, Lima, E., additional, Torres, J., additional, Perdonà, S., additional, Quarto, G., additional, Schips, L., additional, Castellucci, R., additional, Bove, P., additional, Celia, A., additional, De Concilio, B., additional, Derweesh, I., additional, Bindayi, A., additional, Hamilton, Z., additional, Tracey, A., additional, Montorsi, F., additional, and Autorino, R., additional

Published
2018
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37. Minimally invasive partial nephrectomy in the elderly patient: Analysis from the resurge collaborative project

Author

Autorino, R., primary, Larcher, A., additional, Amparore, D., additional, Wallis, C., additional, Pavan, N., additional, Takagi, T., additional, Rha, K., additional, Yang, B., additional, Perdonà, S., additional, Maurer, T., additional, Schips, L., additional, Castellucci, R., additional, Crivellaro, S., additional, Celia, A., additional, De Concilio, B., additional, Furlan, M., additional, Lima, E., additional, Linares, E., additional, Micali, S., additional, Bevilacqua, L., additional, Tracey, A., additional, Umari, P., additional, Antonelli, A., additional, Derweesh, I., additional, Mir, C., additional, Mottrie, A., additional, Capitanio, U., additional, and Porpiglia, F., additional

Published
2018
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38. Perioperative, functional and oncological outcomes of robot-assisted partial nephrectomy for cT2 renal tumors: A multicenter analysis (The ROSULA project)

Author

Bertolo, R.G., primary, Autorino, R., additional, Derweesh, I., additional, Porter, J., additional, Liao, M., additional, Anele, U., additional, Hampton, L., additional, Larcher, A., additional, Capitanio, U., additional, Gallucci, M., additional, Simone, G., additional, Minervini, A., additional, Carini, M., additional, Mari, A., additional, Eun, D., additional, Keehn, A., additional, Perdonà, S., additional, Quarto, G., additional, Ferro, M., additional, Mottrie, A., additional, De Naeyer, G., additional, Chang, K., additional, Rha, K., additional, Uzzo, R., additional, Kutikov, A., additional, Chen, D., additional, Smaldone, M., additional, Schips, L., additional, Berardinelli, F., additional, White, W., additional, Yang, B., additional, Zang, C., additional, Jacobsohn, K., additional, Langenstroer, P., additional, Dasgupta, P., additional, De Luyk, N., additional, Challacombe, B., additional, Kilday, P., additional, Lau, C., additional, Garisto Risco, J.D., additional, Kaouk, J., additional, Sanduram, C., additional, Sulek, J., additional, Ashrafi, A., additional, Aron, M., additional, Gill, I., additional, and Porpiglia, F., additional

Published
2018
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39. Robot-assisted Retroperitoneal Lymph Node Dissection (Ra-RPLND) for massive postchemotherapy retroperitoneal residual mass in mixed germ cell left testicular cancer: Surgical technique and intraoperative vascular complication management

Author

Mirone, V.G., primary, Imbimbo, C., additional, Verze, P., additional, La Rocca, R., additional, Grimaldi, G., additional, Quarto, G., additional, Sorrentino, D., additional, Castaldo, L., additional, Muscariello, R., additional, Izzo, A., additional, and Perdonà, S., additional

Published
2017
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41. Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy

Author

Perdonà, S, Bruzzese, D, Ferro, M, Autorino, R, Marino, A, Mazzarella, C, Perruolo, G, Longo, M, Spinelli, R, Di Lorenzo, G, Oliva, A, De Sio, M, Damiano, R, Altieri, Vincenzo, Terracciano, D., Perdonà, S, Bruzzese, D, Ferro, M, Autorino, Riccardo, Marino, A, Mazzarella, C, Perruolo, G, Longo, M, Spinelli, R, Di Lorenzo, G, Oliva, Adriana, DE SIO, Marco, Damiano, R, Altieri, V, Terracciano, D., Sisto, Perdonà, Bruzzese, Dario, Matteo, Ferro, Riccardo, Autorino, Ada, Marino, Claudia, Mazzarella, Perruolo, Giuseppe, Longo, Michele, Spinelli, Rosa, Giuseppe Di Lorenzo, Andrea, Oliva, Marco De Sio, Rocco, Damiano, Vincenzo, Altieri, and Terracciano, Daniela

Subjects
Male, Prostate cancer, Biopsy, Prostate, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, PHI, Sensitivity and Specificity, Logistic Models, ROC Curve, Antigens, Neoplasm, Biomarkers, Tumor, Humans, PCA3, Prospective Studies, Aged
Abstract

BACKGROUND: Prostate health index (phi) and prostate cancer antigen 3 (PCA3) have been recently proposed as novel biomarkers for prostate cancer (PCa). We assessed the diagnostic performance of these biomarkers, alone or in combination, in men undergoing first prostate biopsy for suspicion of PCa. METHODS: One hundred sixty male subjects were enrolled in this prospective observational study. PSA molecular forms, phi index (Beckman coulter immunoassay), PCA3 score (Progensa PCA3 assay), and other established biomarkers (tPSA, fPSA, and %fPSA) were assessed before patients underwent a 18-core first prostate biopsy. The discriminating ability between PCa-negative and PCa-positive biopsies of Beckman coulter phi and PCA3 score and other used biomarkers were determined. RESULTS: One hundred sixty patients met inclusion criteria. %p2PSA (p2PSA/fPSA × 100), phi and PCA3 were significantly higher in patients with PCa compared to PCa-negative group (median values: 1.92 vs. 1.55, 49.97 vs. 36.84, and 50 vs. 32, respectively, P ≤ 0.001). ROC curve analysis showed that %p2PSA, phi, and PCA3 are good indicator of malignancy (AUCs = 0.68, 0.71, and 0.66, respectively). A multivariable logistic regression model consisting of both the phi index and PCA3 score allowed to reach an overall diagnostic accuracy of 0.77. Decision curve analysis revealed that this "combined" marker achieved the highest net benefit over the examined range of the threshold probability. CONCLUSIONS: phi and PCA3 showed no significant difference in the ability to predict PCa diagnosis in men undergoing first prostate biopsy. However, diagnostic performance is significantly improved by combining phi and PCA3.

Published
2012

42. PLASMATIC SIL 6R/IL-6 RATIO AS APOTENTIAL PREDICTOR OF HIGH GLEASON SUM AT RADICAL PROSTATECTOMY

Author

Ferro, M, Montanino, F, Marsicano, M, Montanaro, V, Terracciano, D, Marino, A, Illiano, E, Prezioso, D, Sio, M, Domenico, R, Sorrentino, D, Quarto, G, Perdonà, S, Altieri, V., SERRETTA, Vincenzo, Ferro, M, Montanino, F, Marsicano, M, Montanaro, V, Terracciano, D, Marino, A, Illiano, E, Prezioso, D, Sio, M, Domenico, R, Sorrentino, D, Quarto, G, Perdonà, S, Serretta, V, and Altieri, V

Subjects
Prostate cancer, interleukins, Gleason, Settore MED/24 - Urologia
Abstract

Background: Approximately 40% of males with low Gleason grade clinically localized prostate cancer (PCa) at biopsy were finally diagnosed with high Gleason grade PCa at radical prostatectomy (RP). Therefore, a more reliable assessment of the Gleason grade prior to RP is required. Readily available modalities such as circulating biomarkers may be useful for this purpose. The aim of this study was to evaluate the ability of preoperative interleukin 6 (IL-6) and its soluble receptor (sIL-6R), as well as urokinase-type plasminogen activator (u- PA), its receptor (u-PAR) and the inhibitor (PAI-1) to predict Gleason score upgrading. Patients and Methods: A total of 51 PCa patients with biopsy Gleason score ≤7 were studied. Preoperative serum samples were collected prior to digital rectal examination (DRE) and TRUS. Blood was collected into non-heparinized tubes and serum was separated within 1 h of blood collection. The serum was stored at –80˚C and then thawed just prior to testing. Serum levels of PSA, free-PSA and IL-6 were measured using the Immulite 2000 automated assay (DPC, Los Angeles, CA, USA). The concentrations of sIL-6R (R&D Systems, Minneapolis, MN, USA), uPA, uPAR and PAI- 1 (Assaypro, Winfield, MO, USA) in serum were determined according to the manufacturer’s instructions using the ELISA test. Every sample was run in duplicate and the mean was used. The differences between the two measurements were minimal. Results: GS upgrading was defined as a Gleason sum increase between biopsy and RP from ≤7 to >7, since this is important for the therapeutic strategy. On this basis, an upgrade was noted in 5 (10%) samples. Median sIL-6R values were found to be significantly higher in patients with GS upgrading (difference in medians, 28.40 ng/ml; 95% CI, 5.60-49.44; p=0.024). The association between sIL-6R and GS upgrading became more significant by using the sIL-6R/IL-6 ratio (difference in medians, 7.77; 95% CI, 1.72-11.28; p=0.011). Sensitivity and specificity of sIL-6R and the sIL-6R/IL-6 ratio were explored by ROC curve analysis (Figure 1). Figure 1. ROC analysis comparing sIL-6R (--) and sIL-6R/IL-6 ratio (–). The results indicated an extremely good ability to predict the probability of biopsy Gleason sum upgrading of the two parameters (sIL-6R: AUC=0.80; 95% CI, 0.63-0.97; p=0.026. sIL-6R/IL-6 ratio: AUC=0.84; 95% CI, 0.69-0.98; p=0.014). The optimal cut-off point for sIL-6R was 76.5 ng/ml, providing a sensitivity of 80% and a specificity of 76%, whereas for the sIL-6R/IL-6 ratio the optimal cut-off point was 13.5 with comparable sensitivity (80%), but higher specificity (83%). Discussion and Conclusion: sIL-6R may be a significant circulating biomarker employed to predict GS upgrading in patients with a biopsy GS ≤7. Moreover, this ability appears to be enhanced by calculating the sIL-6R/IL-6 ratio. These findings may provide an additional ‘staging tool’ for PCa patients, which may be of great significance in guiding clinicians’ treatment choices, according to current guidelines. 1 Shariat SF, Andrews B, Kattan MW, Kim J, Wheeler TM and Slawin KM: Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis. Urology 58: 1008-1015, 2001. 2 Spiotto MT and Chung TD: STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells. Prostate 42: 186-195, 2000. 3 Deeble PD, Murphy DJ, Parsons SJ and Cox ME: Interleukin-6-and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells. Mol Cell Biol 21: 84718482, 2001.

Published
2012

43. SC55 - The effect of obesity and overweight status on complications and survival after minimally invasive kidney surgery in patients with clinical T2 renal masses: Evidences from rosula dataset

Author

Berardinelli, F., Marchioni, M., De Francesco, P., Simone, G., Minervini, A., Perdona, S., Capitanio, U., Ferro, M., Amparone, D., Eun, D., Porter, J., Rha, K., Mottrie, A., White, W., Yang, B., Jacobsohn, K., Uzzo, R., Challacombe, B., Antonio, D., Tuderti, G., Costantini, M., Mari, A., Carini, M., Quarto, G., Larcher, A., De Cobelli, O., De Luyk, N., Sundaram, C., Cindolo, L., Spinozzi, L., Castellucci, R., Haber, G., Montorsi, F., Derweesh, I., Gallucci, M., Kaouk, J., Portpiglia, F., Autorino, R., and Schips, L.

Published
2019
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45. Phase II Study of docetaxel re-treatment in docetaxel-pretreated castration-resistant prostate cancer

Author

Di Lorenzo G, Buonerba C, Faiella A, Rescigno P, Rizzo M, Perdonà S, Riccardi N, Scagliorini S, Scognamiglio F, Masala D, Ferro M, Palmieri G, Aieta M, Marinelli A, Altieri V, De Placido S, Cartenì G., AUTORINO, Riccardo, Di Lorenzo, G, Buonerba, Carlo, Faiella, Adriana, Rescigno, Pasquale, Rizzo, M, Autorino, R, Perdonà, S, Riccardi, N, Scagliorini, S, Scognamiglio, F, Masala, D, Ferro, M, Palmieri, Giovannella, Aieta, M, Marinelli, Alfredo, Altieri, V, DE PLACIDO, Sabino, Cartenì, G., Buonerba, C, Faiella, A, Rescigno, P, Autorino, Riccardo, Palmieri, G, Marinelli, A, and De Placido, S

Subjects
Male, Treatment Outcome, Retreatment, Humans, Prostatic Neoplasms, Antineoplastic Agents, Taxoids, Docetaxel, Middle Aged, Prostate-Specific Antigen, Epidemiologic Methods, Orchiectomy, Aged
Abstract

To determine the activity and tolerability of docetaxel re-treatment after first-line therapy with docetaxel in castration-resistant prostate cancer (CRPC).Between November 2005 and January 2009, 45 patients initially responding to docetaxel and then experiencing disease progression after a period of biochemical remission of at least 5 months were enrolled in a prospective multicenter study and re-treated with docetaxel. The primary endpoint was the biochemical response (biochemical partial response defined as50% prostate-specific antigen [PSA] decline); secondary endpoints were objective response, toxicity, progression-free survival (PFS) and overall survival (OS).Partial PSA responses were observed in 11 patients (24.5%), 4 (25%) of whom also had an objective response. The treatment was well tolerated, with grade 1-2 neutropenia, thrombocytopenia, vomiting and peripheral neuropathy noted in 18 (40%), 11 (24.5%), 8 (17.8%), and 6 (13.3%) patients, respectively. The most common grade 3 toxicity was neutropenia, which was observed in 8 patients (17.8%). Median PFS was 5 months and median OS was 13 months.Docetaxel re-treatment preserves anti-tumour activity and is well tolerated in a selected population of pretreated patients with CRPC. Further randomized trials are needed to confirm our preliminary results.

Published
2010

46. Differential role of CD133 and CXCR4 in renal cellcarcinoma

Author

D'Alterio C, Cindolo L, Portella L, Polimeno M, Consales C, Riccio A, Cioffi M, Franco R, Chiodini P, Cartenì G, Mirone V, Longo N, Marra L, Perdonà S, Claudio L, Falsaperla M, Puglisi M, Martignoni G, Ficarra V, Castello G, Scala S., MASCOLO, MASSIMO, STAIBANO, STEFANIA, D'Alterio, C, Cindolo, L, Portella, L, Polimeno, M, Consales, C, Riccio, A, Cioffi, M, Franco, R, Chiodini, P, Cartenì, G, Mirone, V, Longo, N, Marra, L, Perdonà, S, Claudio, L, Mascolo, Massimo, Staibano, Stefania, Falsaperla, M, Puglisi, M, Martignoni, G, Ficarra, V, Castello, G, and Scala, S.

Abstract

The chemokine receptor CXCR4 and CD133, putative stem cell markers, were previously described in renal cancer (RCC). To evaluate the biological and prognostic role of CD133 and CXCR4 in RCC the expression was evaluated through qPCR and immunoblotting in human renal cancer cell lines (786-O, A498, ACHN, CAKI-1, SN12C, TK10, UO31) and patients biopsies. Renal cancer cells and surgical biopsies expressed functional CXCR4 while CD133 was not detectable. CXCR4 and CD133 expression was then evaluated in 240 renal cancer patients through immunohistochemistry. CXCR4 and CD133 were low in 19.1% and 59.6%; intermediate in 20% and 17.9%; high in 60.8% and 22.5% of the cases, respectively. CXCR4 was overexpressed in tumours (p= 0.02), while CD133 was over expressed in healthy tissues (p= 0.04). Disease free survival Kaplan Meier plots suggest that prognosis is unfavourable for patients whose primary tumours express CXCR4 (p= 0.0199) but nor CD133 (p= 0.151) neither the concomitant CXCR4-CD133 (p=0.848) high expression affected prognosis. Analysis of prognostic factors suggests that age, clinical presentation, AJCC stage and CXCR4 had a significant prognostic value at the univariate analysis. The CXCR4 predictive ability was confirmed at the multivariate analysis while no prognostic role was identified for CD133.Thus concomitant CD133 and CXCR4 evaluation is not worth in RCC patient while the CXCR4 prognostic role encourage CXCR4 antagonists as promising therapeutic option.

Published
2010

47. Activity and toxicity of paclitaxel in pretreated metastatic penile cancer patients

Author

DI LORENZO G, CARTENÌ G, GONNELLA A, PERDONÀ S, FERRO M, LONGO N, RESCIGNO P, DORIA F, FAIELLA A, ALTIERI V, PALMIERI G, IMBIMBO C, MIRONE V, PLACIDO S., AUTORINO, Riccardo, DI LORENZO, G, Cartenì, G, Autorino, Riccardo, Gonnella, A, Perdonà, S, Ferro, M, Longo, N, Rescigno, P, Doria, F, Faiella, A, Altieri, V, Palmieri, G, Imbimbo, C, Mirone, V, De, and Placido, S.

Published
2009

49. 42 - Prognostic role of neutrophil-to-lymphocyte ratio in patients with T1G3 non-muscle invasive bladder cancer

Author

Vartolomei, M.D., Ferro, M., Cantiello, F., Lucarelli, G., Di Stasi, S., Guazzoni, G., Busetto, G.M., De Berardinis, F., Rocco, D., Perdona, S., Verze, P., Borghesi, M., Schiavina, R., Almeida, G., Bove, P., Lima, F., Grimaldi, G., Crisan, N., Abu Farhan, A.R., Battaglia, M., Serretta, V., Russo, G.I., Morgia, G., Mirone, V., De Cobelli, O., and Shariat, S.F.

Published
2018
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50. P265 - Minimally invasive partial nephrectomy for elderly patients with renal mass: Morbidity, renal function and oncologic outcomes in the resurge collaborative database

Author

Larcher, A., Capitanio, U., Muttin, F., Antonelli, A., Palumbo, C., Furlan, M., Pavan, N., Trombetta, C., Silvestri, T., Mir, C., Breda, A., Palou, J., Rodriguez Faba, O., Linares, E., Aguilera, A., Takagi, T., Tanabe, K., Porpiglia, F., Bertolo, R., Rha, K., Raheem, A., Maurer, T., Amiel, T., Yang, B., Zang, C., De Naeyer, G., Mottrie, A., Long, J., Fiard, G., De Nunzio, C., Tubaro, A., Ferro, M., de Cobelli, O., Micali, S., Bevilacqua, L., Lima, E., Torres, J., Perdonà, S., Quarto, G., Schips, L., Castellucci, R., Bove, P., Celia, A., De Concilio, B., Derweesh, I., Bindayi, A., Hamilton, Z., Tracey, A., Montorsi, F., and Autorino, R.

Published
2018
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