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232 results on '"Pereira, Marina Alessandra"'

28. INTRAPERITONEAL CHEMOTHERAPY FOR GASTRIC CANCER WITH PERITONEAL CARCINOMATOSIS: STUDY PROTOCOL OF A PHASE II TRIAL

Author

Ramos, Marcus Fernando Kodama Pertille, Pereira, Marina Alessandra, Charruf, Amir Zeide, Victor, Carolina Ribeiro, Gregorio, João Vitor Antunes Marques, Alban, Luciana Bastos Valente, Moniz, Camila Motta Venchiarutti, Zilberstein, Bruno, Mello, Evandro Sobroza de, Hoff, Paulo Marcelo Gehm, Ribeiro Junior, Ulysses, and Dias, Andre Roncon

Subjects
Peritoneal neoplasms, Hyperthermic intraperitoneal chemotherapy, Catheters, Neoplasias gástricas, Quimioterapia combinada, Stomach neoplasms, Drug therapy, combination, Neoplasias peritoneais, Cateteres, Quimioterapia intraperitoneal hipertérmica
Abstract

BACKGROUND: Peritoneal carcinomatosis in gastric cancer is considered a fatal disease, without expectation of definitive cure. As systemic chemotherapy is not sufficient to contain the disease, a multimodal approach associating intraperitoneal chemotherapy with surgery may represent an alternative for these cases. AIMS: The aim of this study was to investigate the role of intraperitoneal chemotherapy in stage IV gastric cancer patients with peritoneal metastasis. METHODS: This study is a single institutional single-arm prospective clinical trial phase II (NCT05541146). Patients with the following inclusion criteria undergo implantation of a peritoneal catheter for intraperitoneal chemotherapy: Stage IV gastric adenocarcinoma; age 18–75 years; Peritoneal carcinomatosis with peritoneal cancer index

Published
2023

29. PREOPERATIVE CHEMOTHERAPY VERSUS UPFRONT SURGERY FOR ADVANCED GASTRIC CANCER: A PROPENSITY SCORE MATCHING ANALYSIS

Author

Hong, Stefany, Pereira, Marina Alessandra, Victor, Carolina Ribeiro, Gregório, João Vitor Antunes, Zilberstein, Bruno, Ribeiro Junior, Ulysses, D'albuquerque, Luiz Augusto Carneiro, and Ramos, Marcus Fernando Kodama Pertille

Subjects
Terapia neoadjuvante, Surgical procedures, operative, Neoplasias gástricas, Propensity score, Stomach neoplasms, Neoadjuvant therapy, Procedimentos cirúrgicos operatórios, Pontuação de propensão, Quimioterapia Combinada, Drug therapy, combination
Abstract

BACKGROUND: Surgical resection remains the main curative therapeutic modality for advanced gastric cancer. Recently, the association of preoperative chemotherapy has allowed the improvement of results without increasing surgical complications. AIMS: To evaluate the surgical and oncological outcomes of preoperative chemotherapy in a real-world setting. METHODS: A retrospective review of gastric cancer patients who underwent gastrectomy was performed. Patients were divided into two groups for analysis: upfront surgery and preoperative chemotherapy. The propensity score matching analysis, including 9 variables, was applied to adjust for potential confounding factors. RESULTS: Of the 536 patients included, 112 (20.9%) were referred for preoperative chemotherapy. Before the propensity score matching analysis, the groups were different in terms of age, hemoglobin level, node metastasis at clinical stage- status, and extent of gastrectomy. After the analysis, 112 patients were stratified for each group. Both were similar for all variables assigned in the score. Patients in the preoperative chemotherapy group had less advanced postoperative p staging (p=0.010), postoperative n staging (p

Published
2023

30. Risk factors for blood transfusion and its prognostic implications in curative gastrectomy for gastric cancer

Author

Kawakami, Lucas Eiki, primary, Bonomi, Pedro Barzan, additional, Pereira, Marina Alessandra, additional, Carvalho, Fabrício Oliveira, additional, Ribeiro Jr, Ulysses, additional, Zilberstein, Bruno, additional, Sampaio, Luciana Ribeiro, additional, Carneiro-D'Albuquerque, Luiz Augusto, additional, and Ramos, Marcus Fernando Kodama Pertille, additional

Published
2023
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36. INTRAPERITONEAL CHEMOTHERAPY FOR GASTRIC CANCER WITH PERITONEAL CARCINOMATOSIS: STUDY PROTOCOL OF A PHASE II TRIAL

Author

Ramos, Marcus Fernando Kodama Pertille, primary, Pereira, Marina Alessandra, additional, Charruf, Amir Zeide, additional, Victor, Carolina Ribeiro, additional, Gregorio, João Vitor Antunes Marques, additional, Alban, Luciana Bastos Valente, additional, Moniz, Camila Motta Venchiarutti, additional, Zilberstein, Bruno, additional, Mello, Evandro Sobroza de, additional, Hoff, Paulo Marcelo Gehm, additional, Ribeiro Junior, Ulysses, additional, and Dias, Andre Roncon, additional

Published
2023
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38. Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer

Author

Pereira, Marina Alessandra, Pertille Ramos, Marcus Fernando Kodama, Dias, André Roncon, Cardili, Leonardo, de Moraes, Rafael Dyer Rodrigues, Ribeiro, Renan Ribeiro E, Alves, Venancio Avancini Ferreira, Zilberstein, Bruno, de Mello, Evandro Sobroza, and Jr, Ulysses Ribeiro

Subjects
Original Article
Abstract

OBJECTIVE: Remnant gastric cancer (RGC) is usually associated with a worse prognosis. As they are less common and very heterogeneous tumors, new prognostic and reliable determinants are required to predict patients’ clinical course for RGC. This study aimed to investigate the tumor-infiltrating lymphocytes (TILs) and programmed cell death ligand 1 (PD-L1) status as prognostic biomarkers in a cohort of patients with RGC to develop an immune-related score. METHODS: Patients with gastric cancer (GC) who underwent curative intent gastrectomy were retrospectively investigated. RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study. The risk score based on immune parameters was developed using binary logistic regression analysis. RGCs were divided into high-risk (HR), intermediate-risk (IR), and low-risk (LR) groups based on their immune score. The markers (CD3+, CD4+/CD8+ T cells and PD-L1) were selected for their potential prognostic, therapeutic value, and evaluated by immunohistochemistry (IHC). RESULTS: A total of 42 patients with RGC were enrolled in the study. The score based on immune parameters exhibited an accuracy of 79% [the area under the receiver operating characteristic curve (AUC)=0.79, 95% confidence interval (95% CI), 0.63−0.94, P=0.002], and the population was divided into 3 prognostic groups: 10 (23.8%) patients were classified as LR, 15 (35.7%) as IR, and 17 (40.5%) as HR groups. There were no differences in clinicopathological and surgical characteristics between the three groups. In survival analysis, HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group. In the multivariate analysis, lymph node metastasis and the immune score risk groups were independent factors related to worse survival. CONCLUSIONS: A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival. Accordingly, tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC.

Published
2022

39. Analysis of Epidermal Growth Factor Receptor (EGFR) Expression and Amplification in Cholangiocarcinoma and Correlation with Histological Types

Author

Costa, Vanesse Maria, primary, Soares, Ibere Cauduro, additional, Pereira, Marina Alessandra, additional, Souza, Nathalia Caroline Santiago e, additional, Assato, Aline Kawassaki, additional, Jukemura, José, additional, Jureidini, Ricardo, additional, Alves, Venâncio Avancini Ferreira, additional, and Mello, Evandro Sobroza, additional

Published
2022
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48. RhoA, Claudin 18, and c-MET in Gastric Cancer: Clinicopathological Characteristics and Prognostic Significance in Curative Resected Patients

Author

Pereira, Marina Alessandra, primary, Ramos, Marcus Fernando Kodama Pertille, additional, Dias, Andre Roncon, additional, Cardili, Leonardo, additional, Ribeiro, Renan Ribeiro e, additional, de Castria, Tiago Biachi, additional, Zilberstein, Bruno, additional, Nahas, Sergio Carlos, additional, Ribeiro, Jr., Ulysses, additional, and de Mello, Evandro Sobroza, additional

Published
2021
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50. Gastric cancer molecular classification based on immunohistochemistry and in situ hybridization: Analysis in western patients after curative-intent surgery

Author

Ramos, Marcus Fernando Kodama Pertille, primary, Pereira, Marina Alessandra, additional, de Mello, Evandro Sobroza, additional, Cirqueira, Cinthya dos Santos, additional, Zilberstein, Bruno, additional, Alves, Venancio Avancini Ferreira, additional, Ribeiro-Junior, Ulysses, additional, and Cecconello, Ivan, additional

Published
2021
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