Search

Objective The diagnosis of endometrial cancer is made by biopsy sampling with pathological analysis, but it is extremely important to make an accurate diagnosis in order to plan the specific treatment, and we suggest that HE4 in the endometrial tissue and in serum could be tools to make the diagnosis more precise. Material and methods Our prospective study compared patients with endometrial cancer against non-endometrial cancer ones, matched with several variables. The inclusion criteria were females older than 18 years old that accepted to participate in the research study but that had never underwent surgery for other oncological pathologies, whether for ovarian, colon, cervical carcinoma or uterine sarcoma, and none of them had received preoperative chemo or radiotherapy; moreover, they could not have any severe renal or liver pathology. All of them had hysterectomy surgery and the endometrium was studied by a pathologist who compared the regular staining with HE4-antibody staining, in addition, there were collected the serum samples previous to the surgery. Results Suggest bad correlation between the tissue HE4 in patients with and without carcinoma, however, the serum HE4 is statistically significant in the diagnosis of endometrial carcinoma (median EC= 123.1 U, median NE=64.67 U, p=0.002), although the CA125 level is not significant (p=0.208). Conclusion Compared to previous studies our results are quite different in the pathological side, but the serum conclusions are positive and very hopeful as the tumor marker HE4 seems to be able to diagnose endometrial cancer.

La cerveza es una bebida natural con bajo contenido en calorías, bajo grado de alcohol, sin grasas ni azúcares y con una cantidad importante de hidratos de carbono, vitaminas y proteínas. Sus cualidades beneficiosas para la salud se basan en la presencia en la cerveza de compuestos antioxidantes (polifenoles), que reducen la presencia de radicales libres en el organismo, y de fitoestrógenos, elementos biosimilares a los estrógenos naturales. En las mujeres gestantes, la cerveza, obviamente sin alcohol, presenta elementos en su composición que la diferencian de otras bebidas fermentadas como es el ácido fólico, vitamina necesaria para prevenir los defectos del tubo neural en el nacimiento o para regular la homocisteína. Con respecto a la lactancia, la suplementación con cerveza sin alcohol, merced a sus polifenoles, aumenta la actividad antioxidante en la leche materna y, por tanto, reduce el estrés oxidativo del neonato tras el nacimiento. En la menopausia, son de especial relevancia sus propiedades antioxidantes, de aporte de vitaminas y nutrientes, por su contenido en fibra y la repercusión de la ingesta de fibra en la salud, así como por su contenido en fitoestrógenos, altamente beneficiosos en la prevención de patologías derivadas del descenso de estrógenos propio de esta etapa de la vida. La osteoporosis, igualmente, es eficazmente combatida por la cerveza. La ingesta de cerveza favorece una mayor masa ósea en las mujeres, independientemente de su estado gonadal Beer is a natural beverage low calorie, low degree of alcohol, no fats or sugars and a significant amount of carbohydrates, vitamins, and proteins. Beneficial health qualities are based on the presence in the beer of antioxidant compounds (polyphenols), which reduce the presence of free radicals in the organism, and phytoestrogens, elements biosimilars to natural estrogens. In pregnant women, beer, obviously alcohol-free, presents elements in its composition that differ it from other fermented beverages as it is the folic acid, vitamin necessary to prevent defects of the neural tube in the fetus or regulate homocysteine. With regard to breastfeeding, beer alcohol-free supplementation increases the antioxidant activity in breast milk and therefore reduces the oxidative stress of the newborn after birth In menopause, the presence of antioxidants, vitamins, nutrients, and dietetic fiber, as well as phytoestrogens, is highly beneficial in the prevention of pathologies arising from the decline in estrogens. Osteoporosis also is effectively combated by the beer. The intake of beer, favors a greater bone mass in women, irrespective of their gonadal status

Se hace una introducción histórica al concepto de menopausia y climaterio seguida de un estudio endocrinológico del mismo. Se estudia la química de los esteroides sexuales y se hace una definición del concepto de osteoporosis con su diferenciación con otras osteopatías. Se aborda la frecuencia y clasificación, así como el metabolismo de la estructura ósea en función de la osteoporosis. Se estudian 182 mujeres a las que se les determina la historia clínica, datos antropométricos, mamografías, ecografía ginecológica, cito y colposcopia, analítica de sangre y orina complete, marcadores de la función ósea y 12 hormonas: la fsh, lh, e1, e2, a2, dhea-s, prl, t, ct, pth, cortisol y somatomedina c. Se valora por densitometria la composición corporal de 9 regiones (cabeza, tronco, columna lumbar, pelvis: cuello, t. De wards, trocanter, brazos, piernas y totalidad corporal, relacionando los datos antropológicos con la grasa, músculo, cmo, cat que nos da 120 gráficas y 28 conclusiones.