10 results on '"Pereira Vasconcelos, Daniel Fernando"'
Search Results
2. Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis.
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Carneiro Gomes, Paulo Roberto, Rodrigues da Rocha, Maria Débora, Sousa Pinho de Lira, John Arlley, da Rocha Coelho, Francisco Alex, Pereira Alves, Even Herlany, Silva Nascimento, Hélio Mateus, Marques de Oliveira, Samara, de Sousa Carmo, Rubens Renato, Torres Araújo, Havila, Pereira da Silva, Felipe Rodolfo, and Pereira Vasconcelos, Daniel Fernando
- Subjects
PERIODONTITIS ,NOSOLOGY ,PERIODONTAL disease ,BIOMARKERS ,SCIENCE databases ,META-analysis - Abstract
Background: A new classification for periodontitis has been adopted in clinical practice. However, there are still discussions regarding this new classification and difficulties in its adoption, both by professionals and researchers. Thus, this study aimed to evaluate which salivary biomarkers are present in periodontitis, following the new classification of periodontal diseases through meta-analysis. Material and Methods: A literature search was carried out in the scientific databases: PubMed, Scielo and Google scholar to select studies. The selection of studies was followed by two authors upon reading of the title, abstract and full text. The necessary data were collected and statistical analyses were performed using the Review Manager statistical software version 5.4, with calculation of Mean Difference, heterogeneity (I²) and funnel plot with P < 0.05. Results: After following the selection criteria, 9 articles were selected for comparison. The studies address the presence of biomarkers in the saliva of patients with periodontitis and their possible use in the monitoring and diagnosis of the disease. For the meta-analytic comparison, a sample size of 1,983 individuals was used. Statistical analyses showed that nitric oxide, IL-6, IL-1B and osteoprotegerin are substances that are significantly present in patients with periodontitis (P < 0.05). Conclusions: IL-6, nitric oxide, IL-1B, TNF-a and osteoprotegerin are among the most present biomarkers in patients with periodontitis, and may be used in the future as a monitoring of periodontal disease. The present study also revealed that there was no statistically significant difference in the concentration of these biomarkers for clinical distinction from periodontitis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Phosphatidylinositol 3-kinase gamma participates in nimesulide-induced hepatic damage
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Pereira, Cynthia Maria C, primary, Júnior, Genilson José Dias, additional, Lima, José Victor do N, additional, Alves Lemos, Sarah Izabelly, additional, da Rocha Rodrigues, Lauanda, additional, dos Santos Ferreira, Jayro, additional, Araújo, Anna Sofia Miranda Loiola, additional, de Oliveira, Joveline Costa, additional, Monteiro, Carlos Eduardo, additional, Franco, Álvaro Xavier, additional, Pereira Alves, Even Herlany, additional, Oliveira Silva, Francisca Géssica, additional, de Carvalho Filgueiras, Marcelo, additional, Soares, Pedro M G, additional, Pereira Vasconcelos, Daniel Fernando, additional, de Oliveira, Jefferson Soares, additional, de Brito, Tarcisio Vieira, additional, and Barbosa, André Luiz Reis, additional
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- 2021
- Full Text
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4. Influence Of Sleeping In Hammocks On The Orthostatic Posture
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Rocha Nóbrega Neto, Antonio de Pádua, primary, Pereira da Silva, Felipe Rodolfo, additional, Cardoso Guimarães Vasconcelos, Any Carolina, additional, Pasqual Marques, Amélia, additional, Kato da Silva, Baldomero Antônio, additional, and Pereira Vasconcelos, Daniel Fernando, additional
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- 2015
- Full Text
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5. Profile of the Brazilian Researcher in Occupational Therapy.
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Guimarães Vasconcelos, Any Carolina Cardoso, Pio Rodrigues, João Pedro, Rodrigues, Ezaíne Costa, and Pereira Vasconcelos, Daniel Fernando
- Abstract
Copyright of Cadernos de Terapia Ocupacional da UFSCar is the property of Cadernos de Terapia Ocupacional da UFSCar and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2014
- Full Text
- View/download PDF
6. Perfil do pesquisador terapeuta ocupacional brasileiro.
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Guimarães Vasconcelos, Any Carolina Cardoso, Pio Rodrigues, João Pedro, Rodrigues, Ezaíne Costa, and Pereira Vasconcelos, Daniel Fernando
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RESEARCH personnel ,AUTHORSHIP ,COLLEGE teachers ,RESEARCH methodology ,MEDICAL specialties & specialists ,OCCUPATIONAL therapy ,POPULATION geography ,PUBLISHING ,RESEARCH ,SEX distribution ,DOCTORAL programs ,DESCRIPTIVE statistics ,EVALUATION - Abstract
Copyright of Cadernos de Terapia Ocupacional da UFSCar is the property of Cadernos de Terapia Ocupacional da UFSCar and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2014
- Full Text
- View/download PDF
7. Lymphotoxin-Alpha Gene Polymorphism +252A/G (rs909253, A/G) Is Associated with Susceptibility to Chronic Periodontitis: A Pilot Study.
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Pereira Vasconcelos, Daniel Fernando, da Silva, Marco Antônio Dias, Marques, Marcelo Rocha, de Brito Júnior, Rui Barbosa, Guimarães Vasconcelos, Any Carolina Cardoso, and Barros, Silvana Pereira
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ALLELES ,PERIODONTITIS ,CHI-squared test ,CHRONIC diseases ,FISHER exact test ,GENES ,GENETIC polymorphisms ,POLYMERASE chain reaction ,PILOT projects ,CASE-control method ,DATA analysis software ,DESCRIPTIVE statistics ,GENETICS ,DISEASE risk factors - Abstract
Background. Periodontal disease leading to clinical findings such as increased periodontal probing depth involves a complex interaction between invading pathogenic microorganisms and the patient's immune system. Lymphotoxin alpha (LT-a) is a potent multifunctional immune modulator that contributes toward susceptibility to immune regulation disorders, including periodontal disease. Objective. In this study, we tested the hypothesis that chronic periodontitis (CP) is associated with polymorphisms of the LT-a gene. Materials and Methods. A total of 126 subjects, 44 healthy subjects, and 82 subjects with CP, were evaluated for periodontal disease by measuring clinical attachment loss and separation. Samples of epithelial cells were obtained for DNA analysis by scraping of the buccal mucosa. The LT-a gene was analyzed by polymerase chain reaction followed by endonuclease digestion with NcoI to analyze restriction fragment length polymorphisms. Results. The LT-a gene (+252A/G) polymorphism was associated with CP. LT-a allele frequencies were significantly different (P = 0.0019) between patients with CP and healthy individuals, with an odds ratio of 2.67 for patients with CP with the G allele. Conclusions. These findings suggest the LT-a gene genotype is a risk indicator for susceptibility to chronic periodontal disease in the Brazilian population studied. [ABSTRACT FROM AUTHOR]
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- 2012
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- View/download PDF
8. Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review.
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Lee, Kwang Seob, Kronbichler, Andreas, Pereira Vasconcelos, Daniel Fernando, Pereira da Silva, Felipe Rodolfo, Ko, Younhee, Oh, Yeon Su, Eisenhut, Michael, Merkel, Peter A., Jayne, David, Amos, Christopher I., Siminovitch, Katherine A., Rahmattulla, Chinar, Lee, Keum Hwa, and Shin, Jae Il
- Subjects
META-analysis ,ANTINEUTROPHIL cytoplasmic antibodies ,VASCULITIS ,SINGLE nucleotide polymorphisms ,MAJOR histocompatibility complex - Abstract
A number of genome-wide association studies (GWASs) and meta-analyses of genetic variants have been performed in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We reinterpreted previous studies using false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP). This study searched publications in PubMed and Excerpta Medica Database (EMBASE) up to February 2018. Identification of noteworthy associations were analyzed using FPRP and BFDP, and data (i.e., odds ratio (OR), 95% confidence interval (CI), p-value) related to significant associations were separately extracted. Using filtered gene variants, gene ontology (GO) enrichment analysis and protein–protein interaction (PPI) networks were performed. Overall, 241 articles were identified, and 7 were selected for analysis. Single nucleotide polymorphisms (SNPs) discovered by GWASs were shown to be noteworthy, whereas only 27% of significant results from meta-analyses of observational studies were noteworthy. Eighty-five percent of SNPs with borderline p-values (5.0 × 10
−8 < p < 0.05) in GWASs were found to be noteworthy. No overlapping SNPs were found between PR3-ANCA and MPO-ANCA vasculitis. GO analysis revealed immune-related GO terms, including "antigen processing and presentation of peptide or polysaccharide antigen via major histocompatibility complex (MHC) class II", "interferon-gamma-mediated (IFN-γ) signaling pathway". By using FPRP and BFDP, network analysis of noteworthy genetic variants discovered genetic risk factors associated with the IFN-γ pathway as novel mechanisms potentially implicated in the complex pathogenesis of ANCA-associated vasculitis. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
9. Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review
- Author
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Lee, Kwang Seob, Kronbichler, Andreas, Pereira Vasconcelos, Daniel Fernando, Pereira Da Silva, Felipe Rodolfo, Ko, Younhee, Oh, Yeon Su, Eisenhut, Michael, Merkel, Peter A, Jayne, David, Amos, Christopher I, Siminovitch, Katherine A, Rahmattulla, Chinar, Lee, Keum Hwa, and Shin, Jae Il
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meta-analysis ,myeloperoxidase ,genome-wide association study ,single nucleotide polymorphism ,antineutrophil cytoplasmic antibody (ANCA) ,vasculitis ,3. Good health ,proteinase 3 - Abstract
A number of genome-wide association studies (GWASs) and meta-analyses of genetic variants have been performed in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We reinterpreted previous studies using false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP). This study searched publications in PubMed and Excerpta Medica Database (EMBASE) up to February 2018. Identification of noteworthy associations were analyzed using FPRP and BFDP, and data (i.e., odds ratio (OR), 95% confidence interval (CI), p-value) related to significant associations were separately extracted. Using filtered gene variants, gene ontology (GO) enrichment analysis and protein⁻protein interaction (PPI) networks were performed. Overall, 241 articles were identified, and 7 were selected for analysis. Single nucleotide polymorphisms (SNPs) discovered by GWASs were shown to be noteworthy, whereas only 27% of significant results from meta-analyses of observational studies were noteworthy. Eighty-five percent of SNPs with borderline p-values (5.0 × 10-8 < p < 0.05) in GWASs were found to be noteworthy. No overlapping SNPs were found between PR3-ANCA and MPO-ANCA vasculitis. GO analysis revealed immune-related GO terms, including "antigen processing and presentation of peptide or polysaccharide antigen via major histocompatibility complex (MHC) class II", "interferon-gamma-mediated (IFN-γ) signaling pathway". By using FPRP and BFDP, network analysis of noteworthy genetic variants discovered genetic risk factors associated with the IFN-γ pathway as novel mechanisms potentially implicated in the complex pathogenesis of ANCA-associated vasculitis.
10. Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review
- Author
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Keum Hwa Lee, Andreas Kronbichler, Daniel Fernando Pereira Vasconcelos, Katherine A. Siminovitch, Younhee Ko, Chinar Rahmattulla, Michael Eisenhut, Kwang Seob Lee, Peter A. Merkel, Christopher I. Amos, Felipe Rodolfo Pereira da Silva, Yeon Su Oh, David Jayne, Jae Il Shin, Kronbichler, Andreas [0000-0002-2945-2946], Pereira Vasconcelos, Daniel Fernando [0000-0002-3331-452X], Pereira da Silva, Felipe Rodolfo [0000-0001-9224-5571], Jayne, David [0000-0002-1712-0637], Lee, Keum Hwa [0000-0002-1511-9587], Shin, Jae Il [0000-0003-2326-1820], and Apollo - University of Cambridge Repository
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lcsh:Medicine ,Single-nucleotide polymorphism ,Genome-wide association study ,antineutrophil cytoplasmic antibody (ANCA) ,Major histocompatibility complex ,Article ,vasculitis ,03 medical and health sciences ,0302 clinical medicine ,Antigen ,single nucleotide polymorphism ,Medicine ,030304 developmental biology ,Anti-neutrophil cytoplasmic antibody ,Genetic association ,030203 arthritis & rheumatology ,Genetics ,0303 health sciences ,genome-wide association study ,biology ,business.industry ,lcsh:R ,General Medicine ,Odds ratio ,medicine.disease ,3. Good health ,proteinase 3 ,meta-analysis ,myeloperoxidase ,biology.protein ,business ,Vasculitis - Abstract
A number of genome-wide association studies (GWASs) and meta-analyses of genetic variants have been performed in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We reinterpreted previous studies using false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP). This study searched publications in PubMed and Excerpta Medica Database (EMBASE) up to February 2018. Identification of noteworthy associations were analyzed using FPRP and BFDP, and data (i.e., odds ratio (OR), 95% confidence interval (CI), p-value) related to significant associations were separately extracted. Using filtered gene variants, gene ontology (GO) enrichment analysis and protein&ndash, protein interaction (PPI) networks were performed. Overall, 241 articles were identified, and 7 were selected for analysis. Single nucleotide polymorphisms (SNPs) discovered by GWASs were shown to be noteworthy, whereas only 27% of significant results from meta-analyses of observational studies were noteworthy. Eighty-five percent of SNPs with borderline p-values (5.0 ×, 10&minus, 8 <, p <, 0.05) in GWASs were found to be noteworthy. No overlapping SNPs were found between PR3-ANCA and MPO-ANCA vasculitis. GO analysis revealed immune-related GO terms, including &ldquo, antigen processing and presentation of peptide or polysaccharide antigen via major histocompatibility complex (MHC) class II&rdquo, &ldquo, interferon-gamma-mediated (IFN-&gamma, ) signaling pathway&rdquo, By using FPRP and BFDP, network analysis of noteworthy genetic variants discovered genetic risk factors associated with the IFN-&gamma, pathway as novel mechanisms potentially implicated in the complex pathogenesis of ANCA-associated vasculitis.
- Published
- 2019
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