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Your search keyword '"Perez, Maria-Thereza R."' showing total 16 results
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16 results on '"Perez, Maria-Thereza R."'

14. CNS Progenitor Cells Promote a Permissive Environment for Neurite Outgrowth via a Matrix Metalloproteinase-2- Dependent Mechanism.

Author

Yiqin Zhang, Klassen, Henry J., Tucker, Budd A., Perez, Maria-Thereza R., and Young, Michael J.

Subjects
CENTRAL nervous system surgery, CELL transplantation, NEURONS, APOPTOSIS, RETINAL degeneration, NEUROGLIA, PROTEOLYSIS, NERVOUS system regeneration
Abstract

Transplantation of progenitor cells to the CNS has shown promise in neuronal and glial replacement and as a means of rescuing host neurons from apoptosis. Here we examined the effect of progenitor grafts on neurite extension in the degenerating retina of rd1 (retinal degeneration 1) mice. Transplantation of retinal progenitor cells induced increased matrix metalloproteinase-2(MMP2) secretion, partly from activated glial cells, which was then activated by neuronally expressed MMP14. Active MMP2 resulted in proteolysis of the neurite outgrowth inhibitors CD44 and neurocan in the degenerative retina, allowing significantly increased neurite outgrowth across the border between abutting nondystrophic and rd1 retinas. Progenitor-induced enhancement of outgrowth was abrogated by an MMP inhibitor or by coculture with retinal explants from MMP2-/- mice. This study provides the first identification of an MMP2-dependent mechanism by which exogenous progenitor cells alter the host environment to promote neural regeneration. This suggests a novel therapeutic role for progenitor cells in the treatment of CNS degenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2007
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15. In situhybridization of neuropeptide Y NPY mRNA in the goldfish brain

Author

Vecino, Elena, Perez, Maria-Thereza R., and Ekström, Peter

Abstract

THE distribution of neurones expressing neuropeptide Y (NPY) mRNA in the brain of the goldfish was investigated using a non-radioactive in situhybridization technique. Neurones expressing NPY mRNA were located in cell groups previously shown to exhibit NPY immunoreactivity in the ventral telencephalon, thalamus, optic tectum, and a region adjacent to the locus coeruleus. In addition, neurones expressing NPY mRNA were observed in the diffuse nucleus of the torus lateralis, and in the mesencephalic tegmentum. Our results suggest that in the two latter groups of neurones the rate of transport of NPY from the perikarya is higher, or that NPY is not synthesized at levels detectable by immunocytochemistry.

Published
1994

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