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5. Conditioned taste aversion induced by ethanol in alcohol-preferring rats: influence of the method of ethanol administration

Author

Ciccocioppo, R., Angeletti, S., Chhada, M., Perfumi, M., Froldi, Rino, and Massi, M.

Subjects
Conditioned taste aversion, Marchigian Sardinian alcohol-preferring rats, Intragastric ethanol administration, Intraperitoneal ethanol administration, Conditioned taste aversion, Intragastric ethanol administration, Marchigian Sardinian alcohol-preferring rats, Intraperitoneal ethanol administration
Published
1999

18. Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats.

Author

Mattioli, L., Funari, C., and Perfumi, M.

Subjects
ROSEROOT, ALTERNATIVE medicine, ANTIDEPRESSANTS, MENTAL depression, DEPRESSED persons, TRADITIONAL medicine
Abstract

Rhodiola rosea L. is one of the most popular adaptogen and an antistress plant in European and Asiatic traditional medicine. Our previous studies have confirmed the adaptogenic and antistress properties of a single administration of R. rosea L. extract in rats exposed to acute stress. There is increasing evidence that prolonged exposure to stressful life events and depression are both related to significant behavioural, endocrinological and neurobiological changes in human and animal subjects. The aim of this study was to determine whether chronic treatment with a hydroalcoholic R. rosea extract (RHO) standardized in 3% rosavin and 1% salidroside can prevent alterations induced in female rats following 6 weeks of a chronic mild stress (CMS) procedure. This was analysed through the behavioural and physiological parameters of consumption of 1% sucrose solution, locomotor and exploratory activities, body weight gain and oestrous cycle length. After the first 3 weeks of stress, RHO was administered daily by gavage at doses of 10, 15 and 20 mg/kg for the remaining 3 weeks. In addition, the antidepressant drug fluoxetine (10 mg/kg os), which has been shown to reverse CMS-induced disruptions, was used as the reference treatment. Rats subjected to the CMS procedure demonstrated decreased sucrose intake, reduced moving behaviour, minimized weight gain and dysregulation of their oestrous cycle. Treatment with RHO completely reverted all of these changes. The effects of RHO were comparable to those of fluoxetine. Interestingly, neither RHO nor fluoxetine influence the behavioural and physiological parameters tested in non-stressed animals. These findings strongly showed that chronic administration of RHO results in potent inhibition of the behavioural and physiological changes induced by chronic exposure to mild stressors. [ABSTRACT FROM AUTHOR]

Published
2009
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27. Neonatal Capsaicin Treatment Affects Rat Thymocyte Proliferation and Cell Death by Modulating Substance P and Neurokinin-1 Receptor Expression

Author

Santoni, G., Amantini, C., Lucciarini, R., Perfumi, M., Pompei, P., and Piccoli, M.

Abstract

AbstractHerein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4– CD8– cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration. SP-induced enhancement of thymus cellularity parallels its ability of inhibiting the thymocyte apoptotic program. Indeed, exogenously administered SP completely nullified CPS-induced apoptosis, and SR140333 abrogated the SP-mediated protective effect. SP administration also stimulated concanavalin A (Con A)-induced thymocyte proliferation of CPS-treated rats, completely reversing the CPS-induced inhibition. The SP-mediated stimulation of Con A-induced thymocyte proliferation was NK-1R dependent as shown by concomitant administration of SP and SR140333 to CPS-treated rats. Our results also demonstrate that CPS treatment induces a marked decrease of thymocyte PPT-A mRNA level and endogenous SP content as evaluated by quantitative RT-PCR, in situ hybridization and cytofluorimetric analysis. By contrast, NK-1R mRNA levels were increased in thymocytes from CPS-treated rats. Exogenous SP administration augmented PPT-A, SP and NK-1R thymocyte expression in CPS-treated rats, and this enhancement was antagonized by SR140333 administration. Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells.Copyright © 2004 S. Karger AG, Basel

Published
2004

28. α<INF>2</INF>-Adrenoreceptors Profile Modulation and High Antinociceptive Activity of (S)-(−)-2-[1-(Biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole

Author

Gentili, F., Bousquet, P., Brasili, L., Caretto, M., Carrieri, A., Dontenwill, M., Giannella, M., Marucci, G., Perfumi, M., Piergentili, A., Quaglia, W., Rascente, C., and Pigini, M.

Abstract

A number of derivatives structurally related to cirazoline (1) were synthesized and studied with the purpose of modulating α2-adrenoreceptors selectivity versus both α1-adrenoreceptors and I2 imidazoline binding sites. The most potent α2-agonist was 2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole (7), whose key pharmacophoric features closely matched those found in the α2-agonist 2-(3-exo-(3-phenylprop-1-yl)-2-exo-norbornyl)amino-2-oxazoline (15).30 (S)-(−)-7 was the most potent of the two enantiomers, confirming the stereospecificity of the interaction with α2-adrenoreceptors. This eutomer was tested on two algesiometric paradigms and, because of the interaction with α2-adrenoreceptors, showed a potent and long-lasting antinociceptive activity, since it was abolished by the selective α2-antagonist RX821002.

Published
2002

31. Spasmolytic Activity of Essential Oil of Artemisia thusculaCav. from the Canary Islands

Author

Perfumi, M., Paparelli, F., and Cingolani, M.L.

Abstract

ABSTRACTThe present in vitro work studied (against carbachol) the spasmolytic activity of the essential oil obtained from the flowers of two chemotypes of Artemisia thuscula, endemic plant in the Canary Islands. Both oils displayed dose-dependent and essentially noncompetitive spasmolytic action. The davanone chemotype (46%) found in the samples gathered from the island of Tenerife, was more potent, and its spasmolytic activity was attributable mainly to the davanone itself. The camphor chemotype (36%) found in the samples gathered from the island of Hierro was less active; its spasmolytic effect clearly is not due to camphor. The spasmolytic effect of this camphor chemotype is believed to be due in part to the β-thujone content; however, the majority of the activity is probably due to other substances present in the oil.

Published
1995
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32. Chemical Constituents and Spasmolytic Activity in Guinea-Pig Ileum of Essential Oil of Artemisia albafrom Two Geographically and Ecologically Different Localities

Author

Perfumi, M., Valentini, G., Bellomaria, B., and Biondi, E.

Abstract

AbstractThe chemical composition and spasmolytic activity in isolated guinea-pig ileum of the essential oil of Artemisia albaTurra has been determined. The oil was hydrodistilled from the plant's flowering tops gathered in two very ecologically different Appennine environments: die gravely substrata of the mean-water bed of the Taro river (Taro-oil)and the calcareous-marly declivities of a modest relief of the central Apennines (Morro di Camerino, Morro-oil). GC and GC/MS analyses of the oil revealed a similar qualitative composition (terpenes and phenols for a total of 59 components identified) with a constant predominance of thujone and camphor in the Taro-oiland a percentage of artemisia ketone in the Morro-oilwhich varied notably in the two harvests gathered in successive years. All the samples demonstrated in vitro(against carbachol) a notable dose-dependent, essentially non-competitive spasmolytic action which was greatest in the sample with the highest content of artemisia ketone.

Published
1999
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