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An extremely schematic model of the forces acting an a sailing yacht equipped with a system of foils is here presented and discussed. The role of the foils is to raise the hull from the water in order to reduce the total resistance and then increase the speed. Some CFD simulations are providing the total resistance of the bare hull at some values of speed and displacement, as well as the characteristics (drag and lift coefficients) of the 2D foil sections used for the appendages. A parametric study has been performed for the characterization of a foil of finite dimensions. The equilibrium of the vertical forces and longitudinal moments, as well as a reduced displacement, is obtained by controlling the pitch angle of the foils. The value of the total resistance of the yacht with foils is then compared with the case without foils, evidencing the speed regime where an advantage is obtained, if any.

Interpolation models are critical for a wide range of applications, from numerical optimization to artificial intelligence. The reliability of the provided interpolated value is of utmost importance, and it is crucial to avoid the insurgence of spurious noise. Noise sources can be prevented using proper countermeasures when the training set is designed, but the data sparsity is inevitable in some cases. A typical example is represented by the application of an optimization algorithm: the area where the minimum or maximum of the objective function is assumed to be present is where new data is abundantly added, but other areas of design variable space are significantly neglected. In these cases, a regularization of the interpolation model becomes absolutely crucial. In this paper we are presenting an approach for the regularization of an interpolator based on the control of its kernel function via the condition number of the self-correlation matrix.

Usually, clinicians assess the correct hemodynamic behavior and fetal well-being during the gestational age thanks to their professional expertise, with the support of some indices defined for Doppler fetal waveforms. Although this approach has demonstrated to be satisfactory in the most of the cases, it can be largely improved with the aid of more advanced techniques, i.e. numerical analysis and simulation. Another key aspect limiting the analysis is that clinicians rely on a limited number of Doppler waveforms observed during the clinical examination. Moreover, the use of simple velocimetric indicators for deriving possible malfunctions of the fetal cardiovascular system can be misleading, being the fetal assessment based on a mere statistical analysis (comparison with physiological ranges), without any deep physio-pathological interpretations of the observed hemodynamic changes. The use of a lumped mathematical model, properly describing the entire fetal cardiovascular system, would be absolutely helpful in this context: by targeting physiological model parameters on the clinical reliefs, we could gain deep insights of the full system. The calibration of model parameters may also help in formulating patient-specific early diagnosis of fetal pathologies. In the present work, we develop a robust parameter estimation algorithm based on two different optimization methods using synthetic data. In particular, we deal with the inverse problem of recognizing the most significant parameters of a lumped fetal circulation model by using time tracings of fetal blood flows and pressures obtained by the model. This represents a first methodological work for the assessment of the accuracy in the identification of model parameters of an algorithm based on closed-loop mathematical model of fetal circulation and opens the way to the application of the algorithm to clinical data., Comment: 33 pages, 6 figures

Numerical optimization of complex systems benefits from the technological development of computing platforms in the last twenty years. Unfortunately, this is still not enough, and a large computational time is still necessary when mathematical models that include richer (and therefore more realistic) physical models are adopted. In this paper we show how the combination of optimization and Artificial Intelligence (AI), in particular the Machine Learning algorithms, can help in strongly reducing the overall computational times, making possible the use of complex simulation systems within the optimization cycle. Original approaches are also proposed.

In this survey we consider mathematical models and methods recently developed to control crowd dynamics, with particular emphasis on egressing pedestrians. We focus on two control strategies: The first one consists in using special agents, called leaders, to steer the crowd towards the desired direction. Leaders can be either hidden in the crowd or recognizable as such. This strategy heavily relies on the power of the social influence (herding effect), namely the natural tendency of people to follow group mates in situations of emergency or doubt. The second one consists in modify the surrounding environment by adding in the walking area multiple obstacles optimally placed and shaped. The aim of the obstacles is to naturally force people to behave as desired. Both control strategies discussed in this paper aim at reducing as much as possible the intervention on the crowd. Ideally the natural behavior of people is kept, and people do not even realize they are being led by an external intelligence. Mathematical models are discussed at different scales of observation, showing how macroscopic (fluid-dynamic) models can be derived by mesoscopic (kinetic) models which, in turn, can be derived by microscopic (agent-based) models., Comment: arXiv admin note: text overlap with arXiv:1504.04064

The definition of an innovative therapeutic protocol requires the fine tuning of all the involved operations in order to maximize the efficiency. In some cases, the price of the experiments, or their duration, represents a great obstacle and the full potential of the protocol risks to be reduced or even hidden by a non-optimal application. The implementation of a numerical model of the protocol may represent the solution, allowing a systematic exploration of all the different alternatives, shedding the light on the most promising combination and also identifying the key elements/parameters. In this paper, the injection of a plasmid, preceded by a hyaluronidase injection, is simulated through a mathematical model. Some key elements of the administration protocol are identified by means of a mathematical optimization procedure, maximizing the efficacy of the therapy. As a side effect of the extensive investigation, robust solutions able to reduce the effects of human errors in the administration are also obtained.

In this paper, we deal with a size-variable group of pedestrians moving in a unknown confined environment and searching for an exit. Pedestrian dynamics are simulated by means of a recently introduced microscopic (agent-based) model, characterized by an exploration phase and an egress phase. First, we study the model to reveal the role of its main parameters and its qualitative properties. Second, we tackle a robust optimization problem by means of the Particle Swarm Optimization method, aiming at reducing the time-to-target by adding in the walking area multiple obstacles optimally placed and shaped. Robustness is sought against the number of people in the group, which is an uncertain quantity described by a random variable with given probability density distribution.

In this paper we are concerned with the simulation of crowds in built environments, where obstacles play a role in the dynamics and in the interactions among pedestrians. First of all, we review the state-of-the-art of the techniques for handling obstacles in numerical simulations. Then, we introduce a new modelling technique which guarantees both impermeability and opacity of the obstacles, and does not require ad hoc runtime interventions to avoid collisions. Most important, we solve a complex optimization problem by means of the Particle Swarm Optimization method in order to exploit the so-called Braess's paradox. More precisely, we reduce the evacuation time from a room by adding in the walking area multiple obstacles optimally placed and shaped.