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1. Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data

Author

Furukawa, Toshi A, Suganuma, Aya, Ostinelli, Edoardo G, Andersson, Gerhard, Beevers, Christopher G, Shumake, Jason, Berger, Thomas, Boele, Florien Willemijn, Buntrock, Claudia, Carlbring, Per, Choi, Isabella, Christensen, Helen, Mackinnon, Andrew, Dahne, Jennifer, Huibers, Marcus J H, Ebert, David D, Farrer, Louise, Forand, Nicholas R, Strunk, Daniel R, Ezawa, Iony D, Forsell, Erik, Kaldo, Viktor, Geraedts, Anna, Gilbody, Simon, Littlewood, Elizabeth, Brabyn, Sally, Hadjistavropoulos, Heather D, Schneider, Luke H, Johansson, Robert, Kenter, Robin, Kivi, Marie, Björkelund, Cecilia, Kleiboer, Annet, Riper, Heleen, Klein, Jan Philipp, Schröder, Johanna, Meyer, Björn, Moritz, Steffen, Bücker, Lara, Lintvedt, Ove, Johansson, Peter, Lundgren, Johan, Milgrom, Jeannette, Gemmill, Alan W, Mohr, David C, Montero-Marin, Jesus, Garcia-Campayo, Javier, Nobis, Stephanie, Zarski, Anna-Carlotta, O'Moore, Kathleen, Williams, Alishia D, Newby, Jill M, Perini, Sarah, Phillips, Rachel, Schneider, Justine, Pots, Wendy, Pugh, Nicole E, Richards, Derek, Rosso, Isabelle M, Rauch, Scott L, Sheeber, Lisa B, Smith, Jessica, Spek, Viola, Pop, Victor J, Ünlü, Burçin, van Bastelaar, Kim M P, van Luenen, Sanne, Garnefski, Nadia, Kraaij, Vivian, Vernmark, Kristofer, Warmerdam, Lisanne, van Straten, Annemieke, Zagorscak, Pavle, Knaevelsrud, Christine, Heinrich, Manuel, Miguel, Clara, Cipriani, Andrea, Efthimiou, Orestis, Karyotaki, Eirini, and Cuijpers, Pim

Published
2021
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2. Do guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis

Author

Karyotaki, Eirini, Ebert, David Daniel, Donkin, Liesje, Riper, Heleen, Twisk, Jos, Burger, Simone, Rozental, Alexander, Lange, Alfred, Williams, Alishia D., Zarski, Anna Carlotta, Geraedts, Anna, van Straten, Annemieke, Kleiboer, Annet, Meyer, Björn, Ünlü Ince, Burçin B., Buntrock, Claudia, Lehr, Dirk, Snoek, Frank J., Andrews, Gavin, Andersson, Gerhard, Choi, Isabella, Ruwaard, Jeroen, Klein, Jan Philipp, Newby, Jill M., Schröder, Johanna, Laferton, Johannes A.C., Van Bastelaar, Kim, Imamura, Kotaro, Vernmark, Kristofer, Boß, Leif, Sheeber, Lisa B., Kivi, Marie, Berking, Matthias, Titov, Nickolai, Carlbring, Per, Johansson, Robert, Kenter, Robin, Perini, Sarah, Moritz, Steffen, Nobis, Stephanie, Berger, Thomas, Kaldo, Viktor, Forsell, Yvonne, Lindefors, Nils, Kraepelien, Martin, Björkelund, Cecilia, Kawakami, Norito, and Cuijpers, Pim

Published
2018
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3. Dismantling, optimising and personalising internet cognitive-behavioural therapy for depression : A systematic review and individual participant data component network meta-analysis

Author

Furukawa, Toshi A, Suganuma, Aya, Ostinelli, Edoardo G., Andersson, Gerhard, Beevers, Christopher G., Shumake, Jason, Berger, Thomas, Boele, Florien Willemijn, Buntrock, Claudia, Carlbring, Per, Choi, Isabella, Christensen, Heleen, Mackinnon, Andrew, Dahne, Jennifer, Huibers, Marcus J.H., D. Ebert, David, Farrer, Louise, Forand, Nicholas R., Strunk, Daniel R., Ezawa, Ionu D., Forsell, Erik, Kaldo, Viktor, Geraedts, Anna, Gilbody, Simon, Littlewood, Liz, Brabyn, Sally, Hadjistavropoulos, Heather D., Schneider, Luke H., Johansson, Robert, Kenter, Robin, Kivi, Marie, Björkelund, Cecilia, Kleiboer, Annet, Riper, Heleen, Klein, Jan Philipp, Schröder, Johanna, Meyer, Björn, Moritz, Steffen, Bücker, Lara, Lintvedt, Ove, Lundgren, Johan, Milgrom, Jeannette, Gemmill, Alan W., Mohr, David C., Montero-Marin, Jesus, Garcia- Campayo, Javier, Nobis, Stephanie, Zarski, Anna-Carlotta, O'Moore, Kathleen, D. Williams, Alishia, Newby, Jill M., Perini, Sarah, Phillips, Rachel, Schneider, Justine, Pots, Wendy, Pugh, Nicole E, Richards, Derek, M. Rosso, Isabelle, Rauch, Scott L., Sheeber, Lisa B., Smith, Jessica, Spek, Viola, Pop, Viktor J., Ünlü, Burçin, van Bastelaar, Kim M. P., van Luenen, Sanne, Garnefski, Nadia, Vernmark, Kristofer, Warmerdam, Lisanne, van Straten, Annemieke, Zagorscak, Pavle, Knaevelsrud, Christine, Heinrich, Manuel, Miguel, Clara, Cipriani, Andrea, Efthimiou, Orestis, Karyotaki, Eirini, and Cuijpers, Pim

Published
2021

9. Be Assertive

Author

Barlow, David H., primary, Rapee, Ronald M., additional, and Perini, Sarah, additional

Published
2014
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11. Conclusion

Author

Barlow, David H., primary, Rapee, Ronald M., additional, and Perini, Sarah, additional

Published
2014
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13. Solve Problems

Author

Barlow, David H., primary, Rapee, Ronald M., additional, and Perini, Sarah, additional

Published
2014
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15. Take Control

Author

Barlow, David H., primary, Rapee, Ronald M., additional, and Perini, Sarah, additional

Published
2014
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18. Contributors

Author

Albano, Anne Marie, primary, Alden, Lynn E., additional, Amado, Danielle, additional, Amir, Nader, additional, Anderson, Kristin N., additional, Auyeung, Karen W., additional, Barrett, Paula, additional, Blanco, Carlos, additional, Bockstaele, Bram Van, additional, Bögels, Susan M., additional, Bragdon, Laura, additional, Brandsma, Lynn L., additional, Brockveld, Keila C., additional, Brozovich, Faith A., additional, Comer, Jonathan S., additional, Cooper, Marita, additional, Crum, Kathleen I., additional, Detweiler, Michael F., additional, Diamond, Allison, additional, Farmer, Antonina S., additional, Fischer, Laura, additional, Flett, Gordon L., additional, Gilbert, Paul, additional, Gilboa-Schechtman, Eva, additional, Goldin, Philippe R., additional, Gross, James J., additional, Hearon, Bridget A., additional, Heimberg, Richard G., additional, Helpman, Liat, additional, Henderson, Lynne, additional, Herbert, James D., additional, Hewitt, Paul L., additional, Hope, Debra A., additional, Jager-Hyman, Shari, additional, Jazaieri, Hooria, additional, Jongman-Sereno, Katrina P., additional, Kagan, Jerome, additional, Kashdan, Todd B., additional, Kauffman, Brooke Y., additional, Klumpp, Heide, additional, Kuckertz, Jennie M., additional, Kyparissis, Angela, additional, Leary, Mark R., additional, Lejuez, C.W., additional, Liebowitz, Michael R., additional, McNeil, Daniel W., additional, Miller, Rowland S., additional, Otto, Michael W., additional, Perini, Sarah J., additional, Phan, K. Luan, additional, Plasencia, Leili, additional, Powers, Mark B., additional, Randall, Cameron L., additional, Rapee, Ronald M., additional, Reich, James, additional, Safren, Steven A., additional, Schneier, Franklin R., additional, Shachar, Iris, additional, Smits, Jasper A.J., additional, Sorrell, John T., additional, Stravynski, Ariel, additional, Weeks, Justin W., additional, Wenzel, Amy, additional, and Zimbardo, Philip, additional

Published
2014
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19. Internet-Based Cognitive Behavioral Therapy for Depression: A Systematic Review and Individual Patient Data Network Meta-analysis

Author

Karyotaki, Eirini, Efthimiou, Orestis, Miguel, Clara, Bermpohl, Frederic Maas Genannt, Furukawa, Toshi A., Cuijpers, Pim, Riper, Heleen, Patel, Vikram, Mira, Adriana, Gemmil, Alan W., Yeung, Albert S., Lange, Alfred, Williams, Alishia D., Mackinnon, Andrew, Geraedts, Anna, Van Straten, Annemieke, Meyer, Björn, Björkelund, Cecilia, Knaevelsrud, Christine, Beevers, Christopher G., Botella, Cristina, Strunk, Daniel R., Mohr, David C., Ebert, David D., Kessler, David, Richards, Derek, Littlewood, Elizabeth, Forsell, Erik, Feng, Fan, Wang, Fang, Andersson, Gerhard, Hadjistavropoulos, Heather, Christensen, Heleen, Ezawa, Iony D., Choi, Isabella, Rosso, Isabelle M., Klein, Jan Philipp, Shumake, Jason, Garcia-Campayo, Javier, Milgrom, Jeannette, Smith, Jessica, Montero-Marin, Jesus, Newby, Jill M., Bretón-López, Juana, Schneider, Justine, Vernmark, Kristofer, Bücker, Lara, Sheeber, Lisa B., Warmerdam, Lisanne, Farrer, Louise, Heinrich, Manuel, Huibers, Marcus J.H., Kivi, Marie, Kraepelien, Martin, Forand, Nicholas R., Pugh, Nicky, Lindefors, Nils, Lintvedt, Ove, Zagorscak, Pavle, Carlbring, Per, Phillips, Rachel, Johansson, Robert, Kessler, Ronald C., Brabyn, Sally, Perini, Sarah, Rauch, Scott L., Gilbody, Simon, Moritz, Steffen, Berger, Thomas, Pop, Victor, Kaldo, Viktor, Spek, Viola, Forsell, Yvonne, Karyotaki, Eirini, Efthimiou, Orestis, Miguel, Clara, Bermpohl, Frederic Maas Genannt, Furukawa, Toshi A., Cuijpers, Pim, Riper, Heleen, Patel, Vikram, Mira, Adriana, Gemmil, Alan W., Yeung, Albert S., Lange, Alfred, Williams, Alishia D., Mackinnon, Andrew, Geraedts, Anna, Van Straten, Annemieke, Meyer, Björn, Björkelund, Cecilia, Knaevelsrud, Christine, Beevers, Christopher G., Botella, Cristina, Strunk, Daniel R., Mohr, David C., Ebert, David D., Kessler, David, Richards, Derek, Littlewood, Elizabeth, Forsell, Erik, Feng, Fan, Wang, Fang, Andersson, Gerhard, Hadjistavropoulos, Heather, Christensen, Heleen, Ezawa, Iony D., Choi, Isabella, Rosso, Isabelle M., Klein, Jan Philipp, Shumake, Jason, Garcia-Campayo, Javier, Milgrom, Jeannette, Smith, Jessica, Montero-Marin, Jesus, Newby, Jill M., Bretón-López, Juana, Schneider, Justine, Vernmark, Kristofer, Bücker, Lara, Sheeber, Lisa B., Warmerdam, Lisanne, Farrer, Louise, Heinrich, Manuel, Huibers, Marcus J.H., Kivi, Marie, Kraepelien, Martin, Forand, Nicholas R., Pugh, Nicky, Lindefors, Nils, Lintvedt, Ove, Zagorscak, Pavle, Carlbring, Per, Phillips, Rachel, Johansson, Robert, Kessler, Ronald C., Brabyn, Sally, Perini, Sarah, Rauch, Scott L., Gilbody, Simon, Moritz, Steffen, Berger, Thomas, Pop, Victor, Kaldo, Viktor, Spek, Viola, and Forsell, Yvonne

Abstract

Importance: Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them. Objective: To provide personalized estimates of short-term and long-term relative efficacy of guided and unguided iCBT for depression using patient-level information. Data Sources: We searched PubMed, Embase, PsycInfo, and Cochrane Library to identify randomized clinical trials (RCTs) published up to January 1, 2019. Study Selection: Eligible RCTs were those comparing guided or unguided iCBT against each other or against any control intervention in individuals with depression. Available individual patient data (IPD) was collected from all eligible studies. Depression symptom severity was assessed after treatment, 6 months, and 12 months after randomization. Data Extraction and Synthesis: We conducted a systematic review and IPD network meta-analysis and estimated relative treatment effect sizes across different patient characteristics through IPD network meta-regression. Main Outcomes and Measures: Patient Health Questionnaire-9 (PHQ-9) scores. Results: Of 42 eligible RCTs, 39 studies comprising 9751 participants with depression contributed IPD to the IPD network meta-analysis, of which 8107 IPD were synthesized. Overall, both guided and unguided iCBT were associated with more effectiveness as measured by PHQ-9 scores than control treatments over the short term and the long term. Guided iCBT was associated with more effectiveness than unguided iCBT (mean difference [MD] in posttreatment PHQ-9 scores, -0.8; 95% CI, -1.4 to -0.2), but we found no evidence of a difference at 6 or 12 months following randomization. Baseline depression was found to be the most important modifier of the relative association for efficacy of guided vs unguided iCBT. Differences between unguided and guided iCBT in people with baseline symptoms of subthreshold depression (P

Published
2021
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20. Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data

Author

Furukawa, Toshi A., Suganuma, Aya, Ostinelli, Edoardo G., Andersson, Gerhard, Beevers, Christopher G., Shumake, Jason, Berger, Thomas, Boele, Florien Willemijn, Buntrock, Claudia, Carlbring, Per, Choi, Isabella, Christensen, Helen, Mackinnon, Andrew, Dahne, Jennifer, Huibers, Marcus J. H., Ebert, David D., Farrer, Louise, Forand, Nicholas R., Strunk, Daniel R., Ezawa, Iony D., Forsell, Erik, Kaldo, Viktor, Geraedts, Anna, Gilbody, Simon, Littlewood, Elizabeth, Brabyn, Sally, Hadjistavropoulos, Heather D., Schneider, Luke H., Johansson, Robert, Kenter, Robin, Kivi, Marie, Bjorkelund, Cecilia, Kleiboer, Annet, Riper, Heleen, Klein, Jan Philipp, Schroder, Johanna, Meyer, Bjorn, Moritz, Steffen, Bucker, Lara, Lintvedt, Ove, Johansson, Peter, Lundgren, Johan, Milgrom, Jeannette, Gemmill, Alan W., Mohr, David C., Montero-Marin, Jesus, Garcia-Campayo, Javier, Nobis, Stephanie, Zarski, Anna-Carlotta, O'Moore, Kathleen, Williams, Alishia D., Newby, Jill M., Perini, Sarah, Phillips, Rachel, Schneider, Justine, Pots, Wendy, Pugh, Nicole E., Richards, Derek, Rosso, Isabelle M., Rauch, Scott L., Sheeber, Lisa B., Smith, Jessica, Spek, Viola, Pop, Victor J., Unlu, Burcin, van Bastelaar, Kim M. P., van Luenen, Sanne, Garnefski, Nadia, Kraaij, Vivian, Vernmark, Kristofer, Warmerdam, Lisanne, van Straten, Annemieke, Zagorscak, Pavle, Knaevelsrud, Christine, Heinrich, Manuel, Miguel, Clara, Cipriani, Andrea, Efthimiou, Orestis, Karyotaki, Eirini, Cuijpers, Pim, Furukawa, Toshi A., Suganuma, Aya, Ostinelli, Edoardo G., Andersson, Gerhard, Beevers, Christopher G., Shumake, Jason, Berger, Thomas, Boele, Florien Willemijn, Buntrock, Claudia, Carlbring, Per, Choi, Isabella, Christensen, Helen, Mackinnon, Andrew, Dahne, Jennifer, Huibers, Marcus J. H., Ebert, David D., Farrer, Louise, Forand, Nicholas R., Strunk, Daniel R., Ezawa, Iony D., Forsell, Erik, Kaldo, Viktor, Geraedts, Anna, Gilbody, Simon, Littlewood, Elizabeth, Brabyn, Sally, Hadjistavropoulos, Heather D., Schneider, Luke H., Johansson, Robert, Kenter, Robin, Kivi, Marie, Bjorkelund, Cecilia, Kleiboer, Annet, Riper, Heleen, Klein, Jan Philipp, Schroder, Johanna, Meyer, Bjorn, Moritz, Steffen, Bucker, Lara, Lintvedt, Ove, Johansson, Peter, Lundgren, Johan, Milgrom, Jeannette, Gemmill, Alan W., Mohr, David C., Montero-Marin, Jesus, Garcia-Campayo, Javier, Nobis, Stephanie, Zarski, Anna-Carlotta, O'Moore, Kathleen, Williams, Alishia D., Newby, Jill M., Perini, Sarah, Phillips, Rachel, Schneider, Justine, Pots, Wendy, Pugh, Nicole E., Richards, Derek, Rosso, Isabelle M., Rauch, Scott L., Sheeber, Lisa B., Smith, Jessica, Spek, Viola, Pop, Victor J., Unlu, Burcin, van Bastelaar, Kim M. P., van Luenen, Sanne, Garnefski, Nadia, Kraaij, Vivian, Vernmark, Kristofer, Warmerdam, Lisanne, van Straten, Annemieke, Zagorscak, Pavle, Knaevelsrud, Christine, Heinrich, Manuel, Miguel, Clara, Cipriani, Andrea, Efthimiou, Orestis, Karyotaki, Eirini, and Cuijpers, Pim

Abstract

Background Internet cognitive behavioural therapy (iCBT) is a viable delivery format of CBT for depression. However, iCBT programmes include training in a wide array of cognitive and behavioural skills via different delivery methods, and it remains unclear which of these components are more efficacious and for whom. Methods We did a systematic review and individual participant data component network meta-analysis (cNMA) of iCBT trials for depression. We searched PubMed, PsycINFO, Embase, and the Cochrane Library for randomised controlled trials (RCTs) published from database inception to Jan 1, 2019, that compared any form of iCBT against another or a control condition in the acute treatment of adults (aged ≥18 years) with depression. Studies with inpatients or patients with bipolar depression were excluded. We sought individual participant data from the original authors. When these data were unavailable, we used aggregate data. Two independent researchers identified the included components. The primary outcome was depression severity, expressed as incremental mean difference (iMD) in the Patient Health Questionnaire-9 (PHQ-9) scores when a component is added to a treatment. We developed a web app that estimates relative efficacies between any two combinations of components, given baseline patient characteristics. This study is registered in PROSPERO, CRD42018104683. Findings We identified 76 RCTs, including 48 trials contributing individual participant data (11 704 participants) and 28 trials with aggregate data (6474 participants). The participants' weighted mean age was 42·0 years and 12 406 (71%) of 17 521 reported were women. There was suggestive evidence that behavioural activation might be beneficial (iMD −1·83 [95% credible interval (CrI) −2·90 to −0·80]) and that relaxation might be harmful (1·20 [95% CrI 0·17 to 2·27]). Baseline severity emerged as the strongest prognostic factor for endpoint depression. Combining human and au

Published
2021
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30. Internet-Based Cognitive Behavioral Therapy for Depression: A Systematic Review and Individual Patient Data Network Meta-analysis.

Author

Karyotaki E, Efthimiou O, Miguel C, Bermpohl FMG, Furukawa TA, Cuijpers P, Riper H, Patel V, Mira A, Gemmil AW, Yeung AS, Lange A, Williams AD, Mackinnon A, Geraedts A, van Straten A, Meyer B, Björkelund C, Knaevelsrud C, Beevers CG, Botella C, Strunk DR, Mohr DC, Ebert DD, Kessler D, Richards D, Littlewood E, Forsell E, Feng F, Wang F, Andersson G, Hadjistavropoulos H, Christensen H, Ezawa ID, Choi I, Rosso IM, Klein JP, Shumake J, Garcia-Campayo J, Milgrom J, Smith J, Montero-Marin J, Newby JM, Bretón-López J, Schneider J, Vernmark K, Bücker L, Sheeber LB, Warmerdam L, Farrer L, Heinrich M, Huibers MJH, Kivi M, Kraepelien M, Forand NR, Pugh N, Lindefors N, Lintvedt O, Zagorscak P, Carlbring P, Phillips R, Johansson R, Kessler RC, Brabyn S, Perini S, Rauch SL, Gilbody S, Moritz S, Berger T, Pop V, Kaldo V, Spek V, and Forsell Y

Subjects
Humans, Cognitive Behavioral Therapy, Depression therapy, Depressive Disorder therapy, Internet-Based Intervention, Network Meta-Analysis
Abstract

Importance: Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them., Objective: To provide personalized estimates of short-term and long-term relative efficacy of guided and unguided iCBT for depression using patient-level information., Data Sources: We searched PubMed, Embase, PsycInfo, and Cochrane Library to identify randomized clinical trials (RCTs) published up to January 1, 2019., Study Selection: Eligible RCTs were those comparing guided or unguided iCBT against each other or against any control intervention in individuals with depression. Available individual patient data (IPD) was collected from all eligible studies. Depression symptom severity was assessed after treatment, 6 months, and 12 months after randomization., Data Extraction and Synthesis: We conducted a systematic review and IPD network meta-analysis and estimated relative treatment effect sizes across different patient characteristics through IPD network meta-regression., Main Outcomes and Measures: Patient Health Questionnaire-9 (PHQ-9) scores., Results: Of 42 eligible RCTs, 39 studies comprising 9751 participants with depression contributed IPD to the IPD network meta-analysis, of which 8107 IPD were synthesized. Overall, both guided and unguided iCBT were associated with more effectiveness as measured by PHQ-9 scores than control treatments over the short term and the long term. Guided iCBT was associated with more effectiveness than unguided iCBT (mean difference [MD] in posttreatment PHQ-9 scores, -0.8; 95% CI, -1.4 to -0.2), but we found no evidence of a difference at 6 or 12 months following randomization. Baseline depression was found to be the most important modifier of the relative association for efficacy of guided vs unguided iCBT. Differences between unguided and guided iCBT in people with baseline symptoms of subthreshold depression (PHQ-9 scores 5-9) were small, while guided iCBT was associated with overall better outcomes in patients with baseline PHQ-9 greater than 9., Conclusions and Relevance: In this network meta-analysis with IPD, guided iCBT was associated with more effectiveness than unguided iCBT for individuals with depression, benefits were more substantial in individuals with moderate to severe depression. Unguided iCBT was associated with similar effectiveness among individuals with symptoms of mild/subthreshold depression. Personalized treatment selection is entirely possible and necessary to ensure the best allocation of treatment resources for depression.

Published
2021
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