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199 results on '"Perotti, Germano"'

2. Lutetium [177Lu]-DOTA-TATE in gastroenteropancreatic-neuroendocrine tumours: rationale, design and baseline characteristics of the Italian prospective observational (REAL-LU) study

Author

Lastoria, Secondo, Rodari, Marcello, Sansovini, Maddalena, Baldari, Sergio, D’Agostini, Antonio, Cervino, Anna Rita, Filice, Angelina, Salgarello, Matteo, Perotti, Germano, Nieri, Alberto, Campana, Davide, Pellerito, Riccardo Emanuele, Pomposelli, Elena, Gaudieri, Valeria, Storto, Giovanni, Grana, Chiara Maria, Signore, Alberto, Boni, Giuseppe, Dondi, Francesco, Simontacchi, Gabriele, and Seregni, Ettore

Published
2024
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4. Teaching Cases in Nuclear Medicine: Non-oncological Applications

Author

Valenza, Venanzio, Bruno, Isabella, Di Giuda, Daniela, Perotti, Germano, Cocciolillo, Fabrizio, Lanni, Valerio, Leccisotti, Lucia, Maccora, Daria, Scolozzi, Valentina, Volterrani, Duccio, editor, Erba, Paola Anna, editor, Carrió, Ignasi, editor, Strauss, H. William, editor, and Mariani, Giuliano, editor

Published
2019
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7. The Role of Lung Density in the Voxel-Based Dosimetry of 90 Y-TARE Evaluated with the Voxel S-Value (VSV) Method and Fast Monte Carlo Simulation.

Author

Capotosti, Amedeo, Moretti, Roberto, Vaccaro, Maria, Ribeiro, Cintia De Almeida, Placidi, Lorenzo, Nardini, Matteo, Meffe, Guenda, Cusumano, Davide, Zagaria, Luca, De Risi, Marina, Perotti, Germano, Leccisotti, Lucia, De Spirito, Marco, Iezzi, Roberto, and Indovina, Luca

Subjects
IMAGING phantoms, ABSORBED dose, MONTE Carlo method, LUNGS, MEDICAL dosimetry
Abstract

(1) Background: In 90Y-TARE treatments, lung-absorbed doses should be calculated according to the manufacturer's instructions, using the MIRD-scheme. This scheme is derived from the assumption that 90Y-microspheres deliver the dose in a water-equivalent medium. Since the density of the lungs is quite different from that of the liver, the absorbed dose to the lungs could vary considerably, especially at the liver/lungs interface. The aim of this work is to compare the dosimetric results obtained by two dedicated software packages implementing a water-equivalent dose calculation and a Monte Carlo (MC) simulation, respectively. (2) Methods: An anthropomorphic IEC phantom and a retrospective selection of 24 patients with a diagnosis of HCC were taken into account. In the phantom study, starting from a 90Y-PET/CT acquisition, the liver cavity was manually fixed with a uniform activity concentration on PET series, while the lung compartment was manually expanded on a CT series to simulate a realistic situation in which the liver and lungs are adjacent. These steps were performed by using MIM 90Y SurePlan. Then, a first simulation was carried out with only the liver cavity filled, while a second one was carried out, in which the lung compartment was also manually fixed with a uniform activity concentration corresponding to 10% lung shunt fraction. MIM 90Y SurePlan was used to obtain Voxel S-Value (VSV) approach dose values; instead, Torch was used to obtain MC approach dose values for both the phantom and the patients. (3) Results: In the phantom study, the percentage mean dose differences (∆D%) between VSV and MC in the first and second simulation, respectively were found to be 1.2 and 0.5% (absolute dose variation, ∆D, of 0.7 and 0.3 Gy) for the liver, −56 and 70% (∆D of −0.3 and −16.2 Gy) for the lungs, and −48 and −60% (∆D of −4.3 and −16.5 Gy) for the Liver/Lungs Edge region. The patient study reports similar results with ∆D% between VSV and MC of 7.0%, 4.1% and 6.7% for the whole liver, healthy liver, and tumor, respectively, while the result was −61.2% for the left lung and −61.1% for both the right lung and lungs. (4) Conclusion: Both VSV and MC allowed accurate radiation dose estimation with small differences (<7%) in regions of uniform water-equivalent density (i.e., within the liver). Larger differences between the two methods (>50%) were observed for air-equivalent regions in the phantom simulation and the patient study. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Dose-Response Analysis in Hepatic Tumors Treated with 90Y-TARE According to a Personalized Dosimetric Workflow: Preliminary Results

Author

Capotosti, Amedeo, primary, Milano, Alessia, additional, Zagaria, Luca, additional, Perotti, Germano, additional, Rizzo, Alessio, additional, Longo, Valentina, additional, De Leoni, Davide, additional, Moretti, Roberto, additional, Breschi, Laura, additional, Meffe, Guenda, additional, Placidi, Lorenzo, additional, Cusumano, Davide, additional, Cerrito, Lucia, additional, Annunziata, Salvatore, additional, Iezzi, Roberto, additional, and Indovina, Luca, additional

Published
2023
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10. Case Reports

Author

Bluemel, Christina, Campos, Francisco, Collarino, Angela, Cramer, Andreas, Dik, Stephan, Giordano, Alessandro, Grimminger, Hanns-Jörg, Groen, Niel, Herrmann, Ken, Horn, Martin, Kajdi, Georg W., Lajaab, Dikra, Paepke, Stefan, Pahisa, Jaume, Paredes, Pilar, Perotti, Germano, Vidal-Sicart, Sergi, Von Meyenfeldt, Erik M., Wendler, Thomas, Herrmann, Ken, editor, Nieweg, Omgo E., editor, and Povoski, Stephen P., editor

Published
2016
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11. Multidisciplinary personalized approach in the management of vulvar cancer - the Vul.Can Team experience

Author

Tagliaferri, Luca, Garganese, Giorgia, DʼAviero, Andrea, Lancellotta, Valentina, Fragomeni, Simona Maria, Fionda, Bruno, Casà, Calogero, Gui, Benedetta, Perotti, Germano, Gentileschi, Stefano, Inzani, Frediano, Corrado, Giacomo, Buwenge, Milly, Morganti, Alessio Giuseppe, Valentini, Vincenzo, Scambia, Giovanni, Gambacorta, Maria Antonietta, and Macchia, Gabriella

Published
2020
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26. Dose-response Analysis in Hepatic Tumors Treated with 90Y-TARE According to a Personalized Dosimetric Workflow: Preliminary Results

Author

Milano, Alessia, Capotosti, Amedeo, Zagaria, Luca, Perotti, Germano, Rizzo, Alessio, Longo, Valentina, De Leoni, Davide, Moretti, Roberto, Breschi, Laura, Meffe, Guenda, Placidi, Lorenzo, Cusumano, Davide, Cerrito, Lucia, Annunziata, Salvatore, Iezzi, Roberto, and Indovina, Luca

Abstract

Background: Transarterial Radioembolization (TARE) is a widespread radiation therapy for unresectable hepatic lesions, but a clear understanding of the dose-response link is still missing. The aim of this preliminary study is to investigate the role of both dosimetric and clinical parameters as classifiers or predictors of response and survival for TARE in hepatic tumors and to present possible response cut-off. Methods: 20 patients treated with glass or resin microspheres according to a personalized workflow were included. Dosimetric parameters were extracted from personalized absorbed dose maps obtained from the convolution of 90Y PET images with 90Y voxel S-values. Results: D95 ≥ 104 Gy and tumor mean absorbed dose MADt ≥ 229 Gy were found to be optimal cut-off values for complete response, while D30 ≥ 180 Gy and MADt ≥ 117 Gy were selected as cut-off values for at least partial response and predicted better survival. Clinical parameters Alanine Transaminase (ALT) and Model for End-Stage Liver Disease (MELD) didn’t show sufficient classification capability for response or survival. Concusion: These preliminary results highlight the importance of an accurate dosimetric evaluation and suggest a cautious approach when considering clinical indicators. Dosimetric cut-off values could be a support tool in both planning and post-treatment phases. Larger multi-centric randomized trials, with standardized methods regarding patient selection, response criteria, Regions of Interest definition, dosimetric approach and activity planning are needed to confirm these promising results.

Published
2023
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36. Comparison of Different Positron Emission Tomography Tracers in Patients with Recurrent Medullary Thyroid Carcinoma: Our Experience and a Review of the Literature

Author

Treglia, Giorgio, primary, Castaldi, Paola, additional, Villani, Maria Felicia, additional, Perotti, Germano, additional, Filice, Angelina, additional, Ambrosini, Valentina, additional, Cremonini, Nadia, additional, Versari, Annibale, additional, Fanti, Stefano, additional, Giordano, Alessandro, additional, and Rufini, Vittoria, additional

Published
2012
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38. An Old Tool for an Effective Diagnosis of Thyroid Autonomy

Author

Ianni, Francesca, primary, Perotti, Germano, additional, Paragliola, Rosa Maria, additional, Ricciato, Maria Pia, additional, Castellino, Laura, additional, Prete, Alessandro, additional, Luotto, Valentina, additional, Pontecorvi, Alfredo, additional, and Corsello, Salvatore M, additional

Published
2011
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45. Radiofarmaco per utilizzo diagnostico terapeutico in medicina nucleare e medicina radio guidata

Author

Faccini, Riccardo, Rotili, Dante, Ciogli, Alessia, Cartoni, Antonella, Fratoddi, Ilaria, Venditti, Iole, Giordano, Alessandro, Maccora, Daria, Perotti, Germano, Scotognella, Teresa, and SOLFAROLI CAMILLOCCI, Elena

Subjects
Radiofarmaci, utilizzo diagnostico, utilizzo terapeutico, medicina nucleare, medicina radio guidata, utilizzo terapeutico, medicina nucleare, medicina radio guidata, utilizzo diagnostico, Radiofarmaci
Published
2019

47. Liver Transplantation in Patients with Alcoholic Liver Disease: A Retrospective Study

Author

Vassallo, Gabriele A., Tarli, Claudia, Rando, Maria Margherita, Mosoni, Carolina, Mirijello, Antonio, Agyei-Nkansah, Adwoa, Antonelli, Mariangela, Sestito, Luisa, Perotti, Germano, Di Giuda, Daniela, Agnes, Salvatore, Grieco, Antonio, Gasbarrini, Antonio, Addolorato, Giovanni, Abbate, Valeria, Ainora, Maria Elena, Annicchiarico, Brigida Eleonora, Avolio, Alfonso Wolfango, Biolato, Marco, Calia, Rosaria, De Matthaeis, Nicoletta, Cristina d'Angelo, Null, Ferrarese, Daniele, Ferrulli, Anna, Garcovich, Matteo, Frongillo, Francesco, Marrone, Giuseppe, Miele, Luca, Nure, Eda, Pietrogiacomi, Paola, Pizzolante, Fabrizio, Pompili, Maurizio, Ponziani, Francesca Romana, Rapaccini, Gian Ludovico, Riccardi, Laura, Rinninella, Emanuele, Sganga, Gabriele, Siciliano, Massimo, and Zocco, Maria Assunta

Subjects
Liver Cirrhosis, Male, Alcoholic liver disease, Cirrhosis, medicine.medical_treatment, Settore MED/18 - CHIRURGIA GENERALE, Medicine (miscellaneous), Kaplan-Meier Estimate, Liver transplantation, Toxicology, Gastroenterology, Liver disease, 0302 clinical medicine, Postoperative Complications, Liver Cirrhosis, Alcoholic, Recurrence, Cause of Death, Alcoholic Liver Diseases | Liver Transplantation | Alcohol Abstinence, Alcohol Abstinence, Liver Diseases, Graft Survival, Liver Neoplasms, General Medicine, Middle Aged, Alcoholic, surgical procedures, operative, Psychiatry and Mental Health, 030211 gastroenterology & hepatology, Female, Adult, Reoperation, medicine.medical_specialty, Liver tumor, 03 medical and health sciences, Internal medicine, Aged, Follow-Up Studies, Humans, Liver Diseases, Alcoholic, Liver Transplantation, Retrospective Studies, Survival Analysis, medicine, Survival rate, business.industry, Postoperative complication, medicine.disease, Transplantation, business, 030217 neurology & neurosurgery
Abstract

Aim Alcoholic liver disease (ALD) is the most common liver disease in the Western World. Liver transplantation (LT) is the treatment for end-stage ALD. However, many transplant centers are still reluctant to transplant these patients because of the risk of alcohol relapse, recurrence of the primary liver disease and associated post-transplant complications. We examined survival rate, prevalence of primary liver disease recurrence, re-transplantation and post-transplant complications among transplanted patients for alcoholic cirrhosis compared with those transplanted for viral cirrhosis. Methods data about patients transplanted for alcoholic and viral cirrhosis at the Gemelli Hospital from January 1995 to April 2016 were retrospectively collected. Survival rate was evaluated according to the Kaplan-Meier method. Recurrence was defined as histological evidence of primary liver disease. Data on the onset of complication, causes of death and graft failure after liver transplant were analyzed. Results There was no statistically significant difference regarding survival rate between the two groups. Only patients transplanted for viral cirrhosis presented with primary liver disease recurrence. There was a higher rate of cancer development in patients transplanted for alcoholic cirrhosis. Cancer was the major cause of death in this population. Risk factors associated with the onset of cancer were a high MELD score at the transplant time and smoking after transplantation. Conclusion ALD is a good indication for LT. Patients transplanted for alcoholic cirrhosis should receive regular cancer screening and should be advised against smoking. Short summary No difference was found between patients transplanted for alcoholic cirrhosis and viral cirrhosis in term of survival rate. Only patients transplanted for viral cirrhosis presented primary liver disease recurrence. A higher rate of cancer development was found in patients transplanted for alcoholic cirrohosis. This complication was associated with post-trasplant smoking.

Published
2018

48. Taralli S, Sollini M, Milella M, Perotti G, Filice A, Menga M, Versari A, Rufini V. (18)F-FDG and (68)Ga-somatostatin analogs PET/CT in patients with Merkel cell carcinoma: a comparison study

Author

Taralli, S, Sollini, M, Milella, M, Perotti, Germano, Filice, A, Menga, M, Versari, A, and Rufini, Vittoria

Subjects
Merkel cell carcinoma, Positron emission tomography/computed tomography, 18F-FDG, 68Ga-somatostatin analogs, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Published
2018

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