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4. Transition et transfert de la néphrologie pédiatrique à la néphrologie adulte : recommandations de la filière maladies rénales rares ORKiD

Author

Lemoine, Sandrine, Radenac, Jennifer, Baudouin, Véronique, Belaiche, Stéphanie, Bertholet-Thomas, Aurélia, Buebuyck, Nathalie, Broux, Françoise, Burtey, Stéphane, Champion, Gérard, Charbit, Marina, Cochat, Pierre, De Parscau, Loïc, Delmas, Yahsou, Dunand, Olivier, Essig, Marie, Guebre-Egziabher, Fitsum, Langellier-Bellevue, Béatrice, Leclerc, Anne-Laure, Merieau, Élodie, Moulin, Bruno, Perrin, Justine, Rousiot, Dominique, Sartoris, Béatrice, Servais, Aude, Nagra, Arvind, and Novo, Robert

Published
2021
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5. Ofatumumab treatment for nephrotic syndrome recurrence after pediatric renal transplantation

Author

Bernard, Josselin, Lalieve, Fanny, Sarlat, Julie, Perrin, Justine, Dehoux, Laurene, Boyer, Olivia, and Godron-Dubrasquet, Astrid

Subjects
Kidneys -- Transplantation, Diseases -- Relapse, Ofatumumab -- Usage -- Complications and side effects, Nephrotic syndrome -- Care and treatment -- Patient outcomes -- Complications and side effects -- Drug therapy, Pediatric research -- Usage, Health
Abstract

Background Relapsing nephrotic syndrome (NS) after transplantation can be a challenge to treat. The result of the consequent long-lasting proteinuria is the loss of the graft. Disease recurrence after renal transplantation occurs in around half of cases, and the efficacy of therapeutic strategies is often limited. Recently, ofatumumab, a second-generation and fully human anti-CD20 monoclonal antibody, has been shown to be effective in severe situations. Methods We retrospectively collected data from the medical records of children with recurrence of NS after renal transplantation treated with ofatumumab in France, after failure of previous treatments. Results Six patients were included in this study in five centers with a median duration of follow-up of 10.5 months. Two different ofatumumab regimens were administered. The primary outcome was proteinuria at 6 months after the last dose of ofatumumab. No patient achieved a complete remission, 3/6 had a partial remission, and 3/6 had no response to ofatumumab. Four patients exhibited a minor allergic reaction with the first infusion. One patient died of infection, as a consequence of multiple factors. No malignancies were observed; however, the time of follow-up was not sufficient to see such disease. Conclusions Altogether, these results suggest ofatumumab has a poor efficacy in treating recurrence of NS after renal transplantation. However, it could be discussed in multidrug-resistant refractory NS, but infectious complications and overimmunosuppression have to be balanced. There is a need for further studies to confirm these findings and safety and to determine a standardized protocol in this indication., Author(s): Josselin Bernard [sup.1] [sup.2] , Fanny Lalieve [sup.3] , Julie Sarlat [sup.4] , Justine Perrin [sup.5] , Laurene Dehoux [sup.6] , Olivia Boyer [sup.6] , Astrid Godron-Dubrasquet [sup.3] , [...]

Published
2020
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6. Enantioselective Approach for Expanding the Three‐Dimensional Space of Tetrahydroquinoline to Develop BET Bromodomain Inhibitors**

Author

Lespinasse, Marie‐Ange, primary, Wei, Kaiyao, additional, Perrin, Justine, additional, Winkler, Matthias, additional, Hamaidia, Sieme, additional, Leroy, Alexis, additional, Macek Jilkova, Zuzana, additional, Philouze, Christian, additional, Marche, Patrice N., additional, Petosa, Carlo, additional, Govin, Jérôme, additional, Emadali, Anouk, additional, and Wong, Yung‐Sing, additional

Published
2022
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8. Anti-Tumor Efficacy of PD-L1 Targeted Alpha-Particle Therapy in a Human Melanoma Xenograft Model

Author

Capitao, Marisa, Perrin, Justine, Simon, Sylvain, Gouard, Sébastien, Chouin, Nicolas, Bruchertseifer, Frank, Morgenstern, Alfred, Rbah-Vidal, Latifa, Chérel, Michel, Scotet, Emmanuel, Labarrière, Nathalie, Guilloux, Yannick, Gaschet, Joëlle, Bernardo, Elizabeth, Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Anti-Tumor Immunosurveillance and Immunotherapy (CRCINA-ÉQUIPE 3), Directorate for Nuclear Safety and Security [Karlsruhe, Germany], European Commission - Joint Research Centre [Karlsruhe, Germany] (EC-JRC), GIP ARRONAX [Nantes] (Saint-Herblain), Université de Nantes (UN), CRLCC René Gauducheau, Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications (CRCINA-ÉQUIPE 1), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)

Subjects
PD-L1, theranostics, [SDV.CAN] Life Sciences [q-bio]/Cancer, melanoma, [SDV.CAN]Life Sciences [q-bio]/Cancer, TAT, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, bismuth-213, lcsh:RC254-282, Article
Abstract

Simple Summary In recent years, the development of immune checkpoint inhibitors, such as anti-PD‑1 and anti-PD-L1, proved to prolong melanoma patient survival and are now used in routine clinical practice. PD-L1 also represents a potent biomarker for in vivo molecular imaging using radiolabeled anti-PD-L1 mAbs and positron emission tomography and is currently in development to select patients and assess response to treatment. The aim of our study was to investigate in a preclinical model of human melanoma if PD-L1 could also be a good target for treatment using targeted alpha-particle therapy. Our results show that targeting PD-L1 with bismuth-213, an alpha particle emitter, was associated with efficient anti-tumor response, significant tumor growth delay, and improved survival. This demonstrates that anti-PD-L1 antibodies could be used as theranostics in molecular imaging but also in targeted alpha-particle therapy to treat the tumor and its stroma. Abstract PD-L1 (programmed death-ligand 1, B7-H1, CD274), the ligand for PD-1 inhibitory receptor, is expressed on various tumors, and its expression is correlated with a poor prognosis in melanoma. Anti-PD-L1 mAbs have been developed along with anti-CTLA-4 and anti-PD-1 antibodies for immune checkpoint inhibitor (ICI) therapy, and anti-PD-1 mAbs are now used as first line treatment in melanoma. However, many patients do not respond to ICI therapies, and therefore new treatment alternatives should be developed. Because of its expression on the tumor cells and on immunosuppressive cells within the tumor microenvironment, PD-L1 represents an interesting target for targeted alpha-particle therapy (TAT). We developed a TAT approach in a human melanoma xenograft model that stably expresses PD-L1 using a 213Bi-anti-human-PD-L1 mAb. Unlike treatment with unlabeled anti-human-PD-L1 mAb, TAT targeting PD-L1 significantly delayed melanoma tumor growth and improved animal survival. A slight decrease in platelets was observed, but no toxicity on red blood cells, bone marrow, liver or kidney was induced. Anti-tumor efficacy was associated with specific tumor targeting since no therapeutic effect was observed in animals bearing PD-L1 negative melanoma tumors. This study demonstrates that anti-PD-L1 antibodies may be used efficiently for TAT treatment in melanoma.

Published
2021
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10. Cell Tracking in Cancer Immunotherapy

Author

Perrin, Justine, primary, Capitao, Marisa, additional, Mougin-Degraef, Marie, additional, Guérard, François, additional, Faivre-Chauvet, Alain, additional, Rbah-Vidal, Latifa, additional, Gaschet, Joëlle, additional, Guilloux, Yannick, additional, Kraeber-Bodéré, Françoise, additional, Chérel, Michel, additional, and Barbet, Jacques, additional

Published
2020
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12. Beware, polyarteritis nodosa still exists in nephrology!

Author

Perrin, Justine, Carvelli, Julie, Gondouin, Bertrand, Daniel, Laurent, Fraisse, Megan, Gaudon, Céline, Bouzana, Fouad, Vacher-Coponat, Henri, Moussi-Francès, Julie, Dussol, Bertrand, Jourde-Chiche, Noemie, Vascular research center of Marseille (VRCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Héritages et Constructions dans le Texte et l'Image (HCTI), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO)-Université de Brest (UBO), Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Chirurgie urologique et transplantation rénale [Hôpital de la Conception - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Physiopathologie de l'Endothelium, Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Brest (UBO), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), and Université de Brest (UBO)-Université de Brest (UBO)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)

Subjects
Male, Insuffisance rénale aiguë, [SDV]Life Sciences [q-bio], Angiography, Contrast Media, Vascularite systémique, Acute Kidney Injury, urologic and male genital diseases, Polyarteritis Nodosa, Diagnosis, Differential, Acute renal failure, Périartérite noueuse, Nephrology, Systemic vasculitis, Humans, Aneurysm polyarteritis nodosa, cardiovascular diseases, Anévrysme, Tomography, X-Ray Computed, Aged
Abstract

International audience; Renal involvement of systemic vasculitides is an emergency in nephrology. Although it has become very rare, the diagnosis of polyarteritis nodosa must be considered in some patients. A 70-year-old patient, previously healthy, presented with acute renal failure and malignant hypertension and abundant albuminuria. Subcutaneous nodule, orchitis and mononeuritis appeared subsequently. The search for auto-immunity or viral infection was negative. Markers of thrombotic microangiopathy, present initially, resolved after blood pressure control. After a renal computed tomography with contrast medium injection was considered normal, without any micro-aneurysm, a renal biopsy was performed. It showed vascular lesions and glomerular ischemia. It was complicated by hemorragic shock after 36hours. The diagnosis of periarteritis nodosa was finally made after arterial angiography showed millimetric renal micro-aneurysms. In case of systemic vasculitis with renal involvement, periarteritis nodosa must be part of differential diagnosis, especially in case of malignant hypertension, subcutaneous nodosa and orchitis, and despite albuminuria. This implies the search for micro-aneurysms with arterial angiography, and the contraindication of renal biopsy, associated with a high risk of severe hemorrhage. Periarteritis nodosa still exists in nephrology, even without hepatitis B infection. The association of acute renal failure with medium vessel vasculitis, with negative ANCA, must alert the nephrologist and lead to arterial angiography not to renal biopsy.

Published
2016

13. Liste des collaborateurs

Author

Bacchetta, Justine, Boyer, Olivia, Adonis-Koffy, Laurence Ya, Allain-Launay, Emma, Allard, Lise, Audard, Vincent, Baudin, Florent, Baudouin, Véronique, Beauvais, Anne, Belot, Alexandre, Bensman, Albert, Bérard, Étienne, Berteloot, Laureline, Berthaud, Romain, Bertholet-Thomas, Aurélia, Bertocchio, Jean-Philippe, Biebuyck, Nathalie, Bonnefoy, Catherine, Botto, Nathalie, Boubred, Farid, Bowman, Lucie, Broux, Françoise, Cailliez, Mathilde, Cambier, Alexandra, Capito, Carmen, Charbit, Marina, Chardot, Christophe, Claris, Olivier, Clavé, Stéphanie, Cochat, Pierre, Collard, Laure, Coste, Marie-Édith, Dalodier, Emmeline, Demède, Delphine, Deschênes, Georges, Dijoud, Frédérique, Dossier, Claire, Dubourg, Laurence, Exantus, Judith, Fargue, Sonia, Fila, Marc, Frémeaux-Bacchi, Véronique, Garaix, Florentine, Garnier, Charlotte, Gillet, Yves, Gonçalves, David, Gubler, Marie-Claire, Guigonis, Vincent, Harambat, Jérôme, Hazan, Myriam, Heidet, Laurence, Hogan, Julien, Hureaux, Marguerite, Iacobelli, Sylvia, Jamin, Agnès, Jouret, François, Keller-Petrot, Isabelle, Kohaut, Jules, Krid, Saoussen, Krug-Tricot, Pauline, Kwon, Theresa, de Labriolle-Vaylet, Claire, Lachaux, Alain, Launay, Élise, Lemoine, Sandrine, Linglart, Agnès, Manucci-Lahoche, Annie, Massardier, Jérôme, Mekahli, Djalila, Morin, Denis, Nathanson, Sylvie, Naud, Corentin, Nobili, François, Novo, Robert, de Parscau, Loïc, Parvex, Paloma, Perrin, Justine, Picard, Cécile, Piètrement, Christine, Putoux, Audrey, Rabant, Marion, Ranchin, Bruno, Robert, Thomas, Rousset-Rouvière, Caroline, Roussey, Gwenaelle, Ryckewaert, Amélie, Salomon, Rémi, Sellier-Leclerc, Anne-Laure, Sérusclat, André, Tanné, Corentin, Thaunat, Olivier, Tsimaratos, Michel, Ulinski, Tim, Vargas-Poussou, Rosa, Vrillon, Isabelle, Zaloszyc, Ariane, and Zennaro, Maria Christina

Published
2020
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14. Les associations d'usagers de la santé et leur regard sur le pharmacien d'officine : Enquêtes réalisées en Lorraine auprès des associations d'usagers de la santé et de pharmaciens d'officine

Author

Perrin, Justine, Université Henri Poincaré - Nancy 1 (UHP), UHP - Université Henri Poincaré, and Emmanuelle Benoit

Subjects
Santé, Pharmacies d'officine, Malades, Pharmaciens, Thèse d'exercice de pharmacie, Non disponible / Not available, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Abstract

Au début des années 1980, le monde médical découvrait de nouveaux acteurs dans le domaine de la santé : les associations d'usagers de la santé. Les droits des usagers de la santé ont considérablement évolué, notamment depuis la loi du 4 mars 2002 relative aux droits des malades et à la qualité du système de santé. Dans notre travail de thèse, nous nous sommes interrogées sur le regard que portent les associations d'usagers de la santé sur le pharmacien d'officine. La première partie de cette thèse est consacrée à une bibliographie sur les associations et les droits des usagers de la santé. Nous étudions tout d'abord les caractéristiques des associations loi 1901 et des associations de droit local d'Alsace-Moselle. Ensuite, nous nous intéressons spécifiquement aux associations d'usagers de la santé : nous étudions leurs caractéristiques, leurs origines, leurs rôles. Enfin, nous examinons les droits des usagers de la santé. La seconde partie de cette thèse est consacrée à notre travail personnel. Tout d'abord, nous présentons les résultats de nos recherches sur l'organisation des associations d'usagers de la santé : nous avons recensé les différentes associations agréées en fonction de leur domaine d'intervention. Ensuite nous présentons les résultats des deux enquêtes que nous avons menées auprès de douze associations d'usagers de la santé agréées en Lorraine et auprès de douze pharmaciens d'officine dans la région nancéenne. Enfin, l'analyse et la confrontation des résultats de ces deux enquêtes nous permettent d'ouvrir notre réflexion sur la profession officinale, dans un contexte où celle-ci est en pleine évolution avec le projet de loi "Hôpital, Patients, Santé et Territoires".

Published
2009

15. Enantioselective Approach for Expanding the Three-Dimensional Space of Tetrahydroquinoline to Develop BET Bromodomain Inhibitors.

Author

Lespinasse MA, Wei K, Perrin J, Winkler M, Hamaidia S, Leroy A, Macek Jilkova Z, Philouze C, Marche PN, Petosa C, Govin J, Emadali A, and Wong YS

Subjects
Stereoisomerism, Catalysis, Quinolines, Antineoplastic Agents
Abstract

The pharmaceutical industry has a pervasive need for chiral specific molecules with optimal affinity for their biological targets. However, the mass production of such compounds is currently limited by conventional chemical routes, that are costly and have an environmental impact. Here, we propose an easy access to obtain new tetrahydroquinolines, a motif found in many bioactive compounds, that is rapid and cost effective. Starting from simple raw materials, the procedure uses a proline-catalyzed Mannich reaction followed by the addition of BF 3  ⋅ OEt 2 , which generates a highly electrophilic aza-ortho-quinone methide intermediate capable of reacting with different nucleophiles to form the diversely functionalized tetrahydroquinoline. Moreover, this enantioselective one-pot process provides access for the first time to tetrahydroquinolines with a cis-2,3 and trans-3,4 configuration. As proof of concept, we demonstrate that a three-step reaction sequence, from simple and inexpensive starting compounds and catalysts, can generate a BD2-selective BET bromodomain inhibitor with anti-inflammatory effect., (© 2022 Wiley-VCH GmbH.)

Published
2022
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16. [Recommendations for management of patients from pediatrics unit to adult unit: Transition and transfer program].

Author

Lemoine S, Radenac J, Baudouin V, Belaiche S, Bertholet-Thomas A, Buebuyck N, Broux F, Burtey S, Champion G, Charbit M, Cochat P, De Parscau L, Delmas Y, Dunand O, Essig M, Guebre-Egziabher F, Langellier-Bellevue B, Leclerc AL, Merieau É, Moulin B, Perrin J, Rousiot D, Sartoris B, Servais A, Nagra A, and Novo R

Subjects
Adult, Child, Hospital Units, Humans, Pediatrics, Transition to Adult Care
Published
2021
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17. [Beware, polyarteritis nodosa still exists in nephrology!]

Author

Perrin J, Carvelli J, Gondouin B, Daniel L, Fraisse M, Gaudon C, Bouzana F, Vacher-Coponat H, Moussi-Francès J, Dussol B, and Jourde-Chiche N

Subjects
Acute Kidney Injury etiology, Aged, Diagnosis, Differential, Humans, Male, Polyarteritis Nodosa complications, Polyarteritis Nodosa diagnostic imaging, Acute Kidney Injury diagnosis, Angiography methods, Contrast Media administration & dosage, Nephrology, Polyarteritis Nodosa diagnosis, Tomography, X-Ray Computed methods
Abstract

Renal involvement of systemic vasculitides is an emergency in nephrology. Although it has become very rare, the diagnosis of polyarteritis nodosa must be considered in some patients. A 70-year-old patient, previously healthy, presented with acute renal failure and malignant hypertension and abundant albuminuria. Subcutaneous nodule, orchitis and mononeuritis appeared subsequently. The search for auto-immunity or viral infection was negative. Markers of thrombotic microangiopathy, present initially, resolved after blood pressure control. After a renal computed tomography with contrast medium injection was considered normal, without any micro-aneurysm, a renal biopsy was performed. It showed vascular lesions and glomerular ischemia. It was complicated by hemorragic shock after 36hours. The diagnosis of periarteritis nodosa was finally made after arterial angiography showed millimetric renal micro-aneurysms. In case of systemic vasculitis with renal involvement, periarteritis nodosa must be part of differential diagnosis, especially in case of malignant hypertension, subcutaneous nodosa and orchitis, and despite albuminuria. This implies the search for micro-aneurysms with arterial angiography, and the contraindication of renal biopsy, associated with a high risk of severe hemorrhage. Periarteritis nodosa still exists in nephrology, even without hepatitis B infection. The association of acute renal failure with medium vessel vasculitis, with negative ANCA, must alert the nephrologist and lead to arterial angiography not to renal biopsy., (Copyright © 2016 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.)

Published
2016
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