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32 results on '"Perrone, Elisabetta"'

8. Impressive Response to TANDEM Peptide Receptor Radionuclide Therapy with 177 Lu/ 225 AcDOTA-LM3 Somatostatin Receptor Antagonist in a Patient with Therapy-Refractory, Rapidly Progressive Neuroendocrine Neoplasm of the Pancreas.

Author

Perrone, Elisabetta, Ghai, Kriti, Eismant, Aleksandr, Andreassen, Mikkel, Langer, Seppo W., Knigge, Ulrich, Kjaer, Andreas, and Baum, Richard P.

Subjects
*PEPTIDE receptors, *SOMATOSTATIN receptors, *NEUROENDOCRINE tumors, *PANCREATIC tumors, *POSITRON emission tomography, *PANCREAS
Abstract

The present report describes the history of a 58-year-old woman with a rapidly progressing neuroendocrine pancreatic tumor (initially G2) presenting with extensive liver, bone, and lymph node metastases. Previous treatments included chemotherapy, hemithyroidectomy for right lobe metastasis, Peptide Receptor Radionuclide Therapy (PRRT) with [177Lu]Lu-DOTATATE, Lanreotide, Everolimus, and liver embolization. Due to severe disease progression, after a liver biopsy revealing tumor grade G3, PRRT with the somatostatin receptor antagonist LM3 was initiated. [68Ga]GaDOTA-LM3 PET/CT showed intense tracer uptake in the liver, pancreatic tumor, lymph nodes, and bone metastases. Three TANDEM-PRRT cycles using [177Lu]LuDOTA-LM3 and [225Ac]AcDOTA-LM3, administered concurrently, resulted in significant improvement, notably in liver metastases, hepatomegaly reduction, the complete regression of bone and lymph node metastases, and primary tumor improvement. Partial remission was confirmed by positron emission tomography/computed tomography, chest–abdomen–pelvis contrast-enhanced computed tomography, and magnetic resonance of the abdomen, with marked clinical improvement in pain, energy levels, and quality of life, enabling full resumption of physical activity. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC)

Author

Russo, Fabiana, primary, Vandelli, Maria Angela, additional, Biagini, Giuseppe, additional, Schmid, Martin, additional, Luongo, Livio, additional, Perrone, Michela, additional, Ricciardi, Federica, additional, Maione, Sabatino, additional, Laganà, Aldo, additional, Capriotti, Anna Laura, additional, Gallo, Alfonso, additional, Carbone, Luigi, additional, Perrone, Elisabetta, additional, Gigli, Giuseppe, additional, Cannazza, Giuseppe, additional, and Citti, Cinzia, additional

Published
2023
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14. Enantioseparation of Chiral Phytocannabinoids in Medicinal Cannabis

Author

Russo, Fabiana, primary, Tolomeo, Francesco, additional, Vandelli, Maria Angela, additional, Biagini, Giuseppe, additional, Laganà, Aldo, additional, Capriotti, Anna Laura, additional, Cerrato, Andrea, additional, Carbone, Luigi, additional, Perrone, Elisabetta, additional, Cavazzini, Alberto, additional, Maiorano, Vincenzo, additional, Gigli, Giuseppe, additional, Cannazza, Giuseppe, additional, and Citti, Cinzia, additional

Published
2023
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19. Polymeric Membranes Doped with Halloysite Nanotubes Imaged by Proton Microbeam Microscopy

Author

Arima, Valentina, primary, Vasco, Giovanna, additional, Boudjelida, Soufiane, additional, Carraro, Mauro, additional, Bianco, Monica, additional, Zizzari, Alessandra, additional, Perrone, Elisabetta, additional, Galiano, Francesco, additional, Figoli, Alberto, additional, Maruccio, Lucio, additional, Quarta, Gianluca, additional, Calcagnile, Lucio, additional, and Cesaria, Maura, additional

Published
2022
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20. Cis-Δ9-Tetrahydrocannabinolic Acid Occurrence in Cannabis Sativa L

Author

Tolomeo, Francesco, primary, Russo, Fabiana, additional, Kaczorova, Dominika, additional, Vandelli, Maria Angela, additional, Biagini, Giuseppe, additional, Laganà, Aldo, additional, Capriotti, Anna Laura, additional, Paris, Roberta, additional, Fulvio, Flavia, additional, Carbone, Luigi, additional, Perrone, Elisabetta, additional, Gigli, Giuseppe, additional, Cannazza, Giuseppe, additional, and Citti, Cinzia, additional

Published
2022
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22. Highly Sensitive Membrane-Based Pressure Sensors (MePS) for Real-Time Monitoring of Catalytic Reactions

Author

Zizzari, Alessandra, primary, Bianco, Monica, additional, del Mercato, Loretta L., additional, Sorarù, Antonio, additional, Carraro, Mauro, additional, Pellegrino, Paolo, additional, Perrone, Elisabetta, additional, Monteduro, Anna G., additional, Bonchio, Marcella, additional, Rinaldi, Rosaria, additional, Viola, Ilenia, additional, and Arima, Valentina, additional

Published
2018
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26. Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals

Author

Arima, Valentina, primary, Pascali, Giancarlo, additional, Lade, Oliver, additional, Kretschmer, Hans R., additional, Bernsdorf, Ingo, additional, Hammond, Victoria, additional, Watts, Paul, additional, De Leonardis, Francesco, additional, Tarn, Mark D., additional, Pamme, Nicole, additional, Cvetkovic, Benjamin Z., additional, Dittrich, Petra S., additional, Vasovic, Nikola, additional, Duane, Russell, additional, Jaksic, Aleksandar, additional, Zacheo, Antonella, additional, Zizzari, Alessandra, additional, Marra, Lucia, additional, Perrone, Elisabetta, additional, Salvadori, Piero A., additional, and Rinaldi, Rosaria, additional

Published
2013
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28. Highly Sensitive Membrane-Based Pressure Sensors (MePS) for Real-Time Monitoring of Catalytic Reactions

Author

Paolo Pellegrino, Valentina Arima, Rosaria Rinaldi, Marcella Bonchio, Loretta L. del Mercato, Mauro Carraro, Antonio Sorarù, Ilenia Viola, Monica Bianco, A. G. Monteduro, Alessandra Zizzari, Elisabetta Perrone, Zizzari, Alessandra, Bianco, Monica, Del Mercato Loretta, L., Soraru, Antonio, Carraro, Mauro, Pellegrino, Paolo, Perrone, Elisabetta, Monteduro, ANNA GRAZIA, Bonchio, Marcella, Rinaldi, R., Viola, Ilenia, and Arima, V.

Subjects
MULTILAYER CAPSULES, High resolution, Nanotechnology, 02 engineering and technology, 010402 general chemistry, OXIDATION, 01 natural sciences, Analytical Chemistry, Catalysis, FORCE, chemistry.chemical_compound, MICROCHANNELS, DEFORMATION, FLOW CHEMISTRY, POLYDIMETHYLSILOXANE, MODULUS, CELLS, Reaction chamber, membrane, Polydimethylsiloxane, catalysis, Chemistry, 021001 nanoscience & nanotechnology, Pressure sensor, 0104 chemical sciences, Highly sensitive, Elastic membrane, Membrane, 0210 nano-technology
Abstract

Functional, flexible, and integrated lab-on-chips, based on elastic membranes, are capable of fine response to external stimuli, so to pave the way for many applications as multiplexed sensors for a wide range of chemical, physical and biomedical processes. Here, we report on the use of elastic thin membranes (TMs), integrated with a reaction chamber, to fabricate a membrane-based pressure sensor (MePS) for reaction monitoring. In particular, the TM becomes the key-element in the design of a highly sensitive MePS capable to monitor gaseous species production in dynamic and temporally fast processes with high resolution and reproducibility. Indeed, we demonstrate the use of a functional MePS integrating a 2 pm thick polydimethylsiloxane TM by monitoring the dioxygen evolution resulting from catalytic hydrogen peroxide dismutation. The operation of the membrane, explained using a diffusion-dominated model, is demonstrated on two similar catalytic systems with catalase-like activity, assembled into polyelectrolyte multilayers capsules. The MePS, tested in a range between 2 and 50 Pa, allows detecting a dioxygen variation of the mu mol L-1 s(-1) order. Due to their structural features, flexibility of integration, and biocompatibility, the MePSs are amenable of future development within advanced lab-on-chips.

Published
2018

29. Multi layered Polyelectrolyte Capsules and Coated Colloids: Cytotoxicity and Uptake by Cancer Cells

Author

Addolorata Coluccia, Elisabetta Perrone, Ilaria Elena Palamà, Ross Rinaldi, Antonio Della Torre, Viviana Vergaro, Roberto Cingolani, Stefano Leporatti, Palama', ILARIA ELENA, Coluccia, Addolorata Maria Luce, della Torre, Antonio, Vergaro, Viviana, Perrone, Elisabetta, Cingolani, Roberto, Rinaldi, Ro, Leporatti, Stefano, I. E., Palamà, A. M. L., Coluccia, A., Della Torre, E., Perrone, R., Cingolani, Rinaldi, Rosaria, and S., Leporatti

Subjects
Colloid, Microcapsules, Materials science, Cytotoxicity, Cancer cell, Biophysics, Uptake, General Materials Science, Polyelectrolyte
Abstract

The internalisation efficiency and cytotoxicity of polymeric microparticles and capsules were studied for three different adherent cell lines: HeLa (human cervice cancer), MCF-7 (human breast cancer) and B104 (murine neuroblastoma). Microparticles of colloidal CaCO3 cores coated with either layerby- layer self-assembled oppositely charged biosynthetic (PSS\PAH) or biodegradable (DXS\PRM) polyelectrolytes and hollow capsules thereof, obtained upon removal of the CaCO3 cores by EDTA, were fabricated. Fluorescent-labeled polymer layers coated onto CaCO3 cores were employed for evaluating cell uptake efficiency. Confocal laser scanning microscopy was used to confirm dissolution of preformed biodegradable multilayers. Cellular viability for all type of colloidal entities was preserved, indicating safety and tolerability of the potential drug carriers.

Published
2010

30. Radiomolecular Theranostics With Fibroblast-Activation-Protein Inhibitors and Peptides.

Author

Baum RP, Novruzov E, Zhao T, Greifenstein L, Jakobsson V, Perrone E, Mishra A, Eismant A, Ghai K, Klein O, Jaeschke B, Benz-Zils D, Cardinale J, Mori Y, Giesel FL, and Zhang J

Abstract

The advancement of theranostics, which combines therapeutic and diagnostic capabilities in oncology, has significantly impacted cancer management. This review explores fibroblast activation protein (FAP) expression in the tumor microenvironment (TME) and its association with various malignancies, highlighting its potential as a theranostic marker for PET/CT imaging using FAP-targeted tracers and for FAP-targeted radiopharmaceutical therapy. We examine the development and clinical applications of FAP inhibitors (FAPIs) and peptides, providing insights into their diagnostic accuracy, initial therapeutic efficacy, and clinical impact across diverse cancer types, as well as the synthesis of novel FAP-targeted ligands. This review aims to showcase the promising outcomes and challenges in integrating FAP-targeted approaches into cancer management., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Frederik L. Giesel is a FAPI co-inventor and is an advisor at Telix Pharma, SOFIE, ABX, and Alpha Fusion and receives royalties from iTheranostics and SOFIE Biosciences. Richard P. Baum is an advisor to 3B Pharmaceuticals (Berlin, Germany), ITM, Full Life Technologies, Sinotau, Jiangsu Huayi Technology, and Telix Pharmaceuticals, and cofounder of RadioVaxx GmbH., (Copyright © 2024. Published by Elsevier Inc.)

Published
2024
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31. 177Lu-PSMA radioligand therapy for isolated bilateral adrenal metastases from prostate cancer.

Author

Perrone E, Ghai K, Eismant A, Konz K, and Baum RP

Subjects
Aged, Humans, Male, Dipeptides therapeutic use, Heterocyclic Compounds, 1-Ring therapeutic use, Prostate-Specific Antigen, Prostatic Neoplasms radiotherapy, Prostatic Neoplasms pathology, Radioisotopes therapeutic use, Adrenal Gland Neoplasms secondary, Adrenal Gland Neoplasms radiotherapy, Lutetium therapeutic use, Radiopharmaceuticals therapeutic use
Published
2024
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32. Breast Relapse of Pediatric B-Cell Acute Lymphoblastic Leukemia After CAR-T Therapy Detected by 18 F-FDG PET/CT.

Author

Perrone E, Taralli S, Pagliara D, Larocca LM, Vinti L, and Leccisotti L

Subjects
Humans, Female, Child, Neoplasm Recurrence, Local diagnostic imaging, Neoplasm Recurrence, Local pathology, Breast Neoplasms diagnostic imaging, Breast Neoplasms therapy, Breast Neoplasms pathology, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography methods, Immunotherapy, Adoptive adverse effects, Immunotherapy, Adoptive methods, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma therapy, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma diagnostic imaging
Abstract

Background: B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy. Medullary and extramedullary disease relapse is a well-known occurrence in B-ALL pediatric patients treated with standard chemo-immunotherapy and, more recently, with chimeric antigen receptor (CAR)-T cell therapy. 18 F-Fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) emerges as a sensitive imaging tool for detecting disease relapse at extra-medullary sites, with only limited literature evidence in the CAR-T therapy setting., Case Report: In a 12-year-old female treated with CAR-T therapy for B-ALL relapse, 18 F-FDG PET/CT scan performed for surveillance, after disease remission, detected a solitary and clinically occult relapse in the breast parenchyma that was histologically confirmed., Conclusion: At our knowledge, this is the first report about a pediatric B-ALL patient with a solitary and occult breast relapse after CAR-T therapy, early discovered by 18 F-FDG PET/CT during disease monitoring., (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2024
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