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1. Non-Small Cell Lung Cancer Testing on Reference Specimens: An Italian Multicenter Experience

Author

Pepe, Francesco, Russo, Gianluca, Venuta, Alessandro, Scimone, Claudia, Nacchio, Mariantonia, Pisapia, Pasquale, Goteri, Gaia, Barbisan, Francesca, Chiappetta, Caterina, Pernazza, Angelina, Campagna, Domenico, Giordano, Marco, Perrone, Giuseppe, Sabarese, Giovanna, Altimari, Annalisa, de Biase, Dario, Tallini, Giovanni, Calistri, Daniele, Chiadini, Elisa, Capelli, Laura, Santinelli, Alfredo, Gulini, Anna Elisa, Pierpaoli, Elisa, Badiali, Manuela, Murru, Stefania, Murgia, Riccardo, Guerini Rocco, Elena, Venetis, Konstantinos, Fusco, Nicola, Morotti, Denise, Gianatti, Andrea, Furlan, Daniela, Rossi, Giulio, Melocchi, Laura, Russo, Maria, De Luca, Caterina, Palumbo, Lucia, Simonelli, Saverio, Maffè, Antonella, Francia di Celle, Paola, Venesio, Tiziana, Scatolini, Maria, Grosso, Enrico, Orecchia, Sara, Fassan, Matteo, Balistreri, Mariangela, Zulato, Elisabetta, Reghellin, Daniela, Lazzari, Elena, Santacatterina, Maria, Piredda, Maria Liliana, Riccardi, Manuela, Laurino, Licia, Roz, Elena, Longo, Domenico, Romeo, Daniela Petronilla, Fazzari, Carmine, Moreno-Manuel, Andrea, Puglia, Giuseppe Diego, Prjibelski, Andrey D., Shafranskaya, Daria, Righi, Luisella, Listì, Angela, Vitale, Domenico, Iaccarino, Antonino, Malapelle, Umberto, and Troncone, Giancarlo

Published
2024
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2. RadioPathomics: Multimodal Learning in Non-Small Cell Lung Cancer for Adaptive Radiotherapy

Author

Tortora, Matteo, Cordelli, Ermanno, Sicilia, Rosa, Nibid, Lorenzo, Ippolito, Edy, Perrone, Giuseppe, Ramella, Sara, and Soda, Paolo

Subjects
Computer Science - Machine Learning, Computer Science - Computer Vision and Pattern Recognition
Abstract

The current cancer treatment practice collects multimodal data, such as radiology images, histopathology slides, genomics and clinical data. The importance of these data sources taken individually has fostered the recent raise of radiomics and pathomics, i.e. the extraction of quantitative features from radiology and histopathology images routinely collected to predict clinical outcomes or to guide clinical decisions using artificial intelligence algorithms. Nevertheless, how to combine them into a single multimodal framework is still an open issue. In this work we therefore develop a multimodal late fusion approach that combines hand-crafted features computed from radiomics, pathomics and clinical data to predict radiation therapy treatment outcomes for non-small-cell lung cancer patients. Within this context, we investigate eight different late fusion rules (i.e. product, maximum, minimum, mean, decision template, Dempster-Shafer, majority voting, and confidence rule) and two patient-wise aggregation rules leveraging the richness of information given by computer tomography images and whole-slide scans. The experiments in leave-one-patient-out cross-validation on an in-house cohort of 33 patients show that the proposed multimodal paradigm with an AUC equal to $90.9\%$ outperforms each unimodal approach, suggesting that data integration can advance precision medicine. As a further contribution, we also compare the hand-crafted representations with features automatically computed by deep networks, and the late fusion paradigm with early fusion, another popular multimodal approach. In both cases, the experiments show that the proposed multimodal approach provides the best results.

Published
2022
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3. Network approach in liquidomics landscape

Author

Santini, Daniele, Botticelli, Andrea, Galvano, Antonio, Iuliani, Michele, Incorvaia, Lorena, Gristina, Valerio, Taffon, Chiara, Foderaro, Simone, Paccagnella, Elisa, Simonetti, Sonia, Fazio, Federico, Scagnoli, Simone, Pomati, Giulia, Pantano, Francesco, Perrone, Giuseppe, De Falco, Elena, Russo, Antonio, and Spinelli, Gian Paolo

Published
2023
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4. Author Correction: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Author

Schettini, Francesco, Chic, Nuria, Brasó-Maristany, Fara, Paré, Laia, Pascual, Tomás, Conte, Benedetta, Martínez-Sáez, Olga, Adamo, Barbara, Vidal, Maria, Barnadas, Esther, Fernández-Martinez, Aranzazu, González-Farre, Blanca, Sanfeliu, Esther, Cejalvo, Juan Miguel, Perrone, Giuseppe, Sabarese, Giovanna, Zalfa, Francesca, Peg, Vicente, Fasani, Roberta, Villagrasa, Patricia, Gavilá, Joaquín, Barrios, Carlos H., Lluch, Ana, Martín, Miguel, Locci, Mariavittoria, De Placido, Sabino, and Prat, Aleix

Published
2023
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6. Standardized and simplified reporting of next-generation sequencing results in advanced non-small-cell lung cancer: Practical indications from an Italian multidisciplinary group

Author

Malapelle, Umberto, Donne, Alessandro Delle, Pagni, Fabio, Fraggetta, Filippo, Rocco, Elena Guerini, Pasello, Giulia, Perrone, Giuseppe, Pepe, Francesco, Vatrano, Simona, Pignata, Sandro, Pinto, Carmine, Pruneri, Giancarlo, Russo, Antonio, Soto Parra, Hector J., Vallone, Stefania, Marchetti, Antonio, Troncone, Giancarlo, and Novello, Silvia

Published
2024
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7. Development and Validation of a Score for Fibrotic Nonalcoholic Steatohepatitis

Author

Tavaglione, Federica, Jamialahmadi, Oveis, De Vincentis, Antonio, Qadri, Sami, Mowlaei, Mohammad Erfan, Mancina, Rosellina Margherita, Ciociola, Ester, Carotti, Simone, Perrone, Giuseppe, Bruni, Vincenzo, Gallo, Ida Francesca, Tuccinardi, Dario, Bianco, Cristiana, Prati, Daniele, Manfrini, Silvia, Pozzilli, Paolo, Picardi, Antonio, Caricato, Marco, Yki-Järvinen, Hannele, Valenti, Luca, Vespasiani-Gentilucci, Umberto, and Romeo, Stefano

Published
2023
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11. Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge

Author

Carotti, Simone, Zingariello, Maria, Francesconi, Maria, D’Andrea, Laura, Latasa, M. Ujue, Colyn, Leticia, Fernandez-Barrena, Maite G., Flammia, Rocco Simone, Falchi, Mario, Righi, Daniela, Pedini, Giorgia, Pantano, Francesco, Bagni, Claudia, Perrone, Giuseppe, Rana, Rosa Alba, Avila, Matias A., Morini, Sergio, and Zalfa, Francesca

Published
2021
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13. FGFR2 testing in cholangiocarcinoma: translating molecular studies into clinical practice

Author

Angerilli, Valentina, Fornaro, Lorenzo, Pepe, Francesco, Rossi, Silvia Maria, Perrone, Giuseppe, Malapelle, Umberto, Fassan, Matteo, Angerilli, Valentina, Fornaro, Lorenzo, Pepe, Francesco, Rossi, Silvia Maria, Perrone, Giuseppe, Malapelle, Umberto, and Fassan, Matteo

Subjects
FGFR2, biomarkers, cholangiocarcinoma, precision medicine, biomarker, Pathology and Forensic Medicine
Abstract

Cholangiocarcinoma (CCA) is a heterogeneous group of neoplasms burdened by a dismal prognosis. Several studies have investigated the genomic profile of CCA and identified numerous druggable genetic alterations, including FGFR2 fusions/rearrangements. Approximately 5-7% of CCAs and 10-20% of intrahepatic iCCAs harbor FGFR2 fusions. With the recent advent of FGFR-targeting therapies into clinical practice, a standardization of molecular testing for FGFR2 alterations in CCA will be necessary. In this review, we describe the technical aspects and challenges related to FGFR2 testing in routine practice, focusing on the comparison between Next-Generation Sequencing (NGS) and FISH assays, the best timing to perform the test, and on the role of liquid biopsy.

Published
2023

14. Colonic Epithelial Permeability to Ions Is Restored after Vedolizumab Treatment and May Predict Clinical Response in Inflammatory Bowel Disease Patients.

Author

Cicala, Michele, Gori, Manuele, Balestrieri, Paola, Altomare, Annamaria, Tullio, Alessandro, Di Cola, Simone, Dejongh, Sander, Graziani, Maria Giovanna, Pagnini, Cristiano, Carotti, Simone, Perrone, Giuseppe, Ribolsi, Mentore, Fiorani, Marcello, Guarino, Michele P. L., and Farré, Ricard

Subjects
INFLAMMATORY bowel diseases, CROHN'S disease, INFLAMMATION, PERMEABILITY, ULCERATIVE colitis
Abstract

Vedolizumab (VDZ) is used for treating inflammatory bowel disease (IBD) patients. A study investigating colonic epithelial barrier function ex vivo following VDZ is lacking. This work aims to evaluate ex vivo the colonic epithelial barrier function in IBD patients at baseline and during VDZ treatment, and to investigate the relationships between barrier function and clinical parameters. Colonic specimens were obtained from 23 IBD patients before, and at 24 and 52 weeks after VDZ treatment, and from 26 healthy volunteers (HV). Transepithelial electrical resistance (TEER, permeability to ions) and paracellular permeability were measured in Ussing chambers. IBD patients showed increased epithelial permeability to ions (TEER, 13.80 ± 1.04 Ω × cm2 vs. HV 20.70 ± 1.52 Ω × cm2, p < 0.001) without changes in paracellular permeability of a 4 kDa probe. VDZ increased TEER (18.09 ± 1.44 Ω × cm2, p < 0.001) after 52 weeks. A clinical response was observed in 58% and 25% of patients at week 24, and in 62% and 50% at week 52, in ulcerative colitis and Crohn's disease, respectively. Clinical and endoscopic scores were strongly associated with TEER. TEER < 14.65 Ω × cm2 predicted response to VDZ (OR 11; CI 2–59). VDZ reduces the increased permeability to ions observed in the colonic epithelium of IBD patients before treatment, in parallel to a clinical, histological (inflammatory infiltrate), and endoscopic improvement. A low TEER predicts clinical response to VDZ therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Think “HER2” different: integrative diagnostic approaches for HER2-low breast cancer

Author

Marchiò, Caterina, primary, Criscitiello, Carmen, additional, Scatena, Cristian, additional, Santinelli, Alfredo, additional, Graziano, Paolo, additional, Malapelle, Umberto, additional, Cursano, Giulia, additional, Venetis, Konstantinos, additional, Fanelli, Giuseppe Nicolò, additional, Pepe, Francesco, additional, Berrino, Enrico, additional, De Angelis, Carmine, additional, Perrone, Giuseppe, additional, Curigliano, Giuseppe, additional, and Fusco, Nicola, additional

Published
2023
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16. Deep pathomics: A new image-based tool for predicting response to treatment in stage III non-small cell lung cancer

Author

Nibid, Lorenzo, primary, Greco, Carlo, additional, Cordelli, Ermanno, additional, Sabarese, Giovanna, additional, Fiore, Michele, additional, Liu, Charles Z., additional, Ippolito, Edy, additional, Sicilia, Rosa, additional, Miele, Marianna, additional, Tortora, Matteo, additional, Taffon, Chiara, additional, Rakaee, Mehrdad, additional, Soda, Paolo, additional, Ramella, Sara, additional, and Perrone, Giuseppe, additional

Published
2023
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17. Glycolytic competence in gastric adenocarcinomas negatively impacts survival outcomes of patients treated with salvage paclitaxel-ramucirumab

Author

Ruzzo, Annamaria, Graziano, Francesco, Bagaloni, Irene, Di Bartolomeo, Maria, Prisciandaro, Michele, Aprile, Giuseppe, Ongaro, Elena, Vincenzi, Bruno, Perrone, Giuseppe, Santini, Daniele, Fornaro, Lorenzo, Vivaldi, Caterina, Tomasello, Gianluca, Loupakis, Fotios, Lonardi, Sara, Fassan, Matteo, Valmasoni, Michele, Sarti, Donatella, Lorenzini, Paola, Catalano, Vincenzo, Bisonni, Renato, Del Prete, Michela, Collina, Guido, and Magnani, Mauro

Published
2020
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18. Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Author

Schettini, Francesco, Chic, Nuria, Brasó-Maristany, Fara, Paré, Laia, Pascual, Tomás, Conte, Benedetta, Martínez-Sáez, Olga, Adamo, Barbara, Vidal, Maria, Barnadas, Esther, Fernández-Martinez, Aranzazu, González-Farre, Blanca, Sanfeliu, Esther, Cejalvo, Juan Miguel, Perrone, Giuseppe, Sabarese, Giovanna, Zalfa, Francesca, Peg, Vicente, Fasani, Roberta, Villagrasa, Patricia, Gavilá, Joaquín, Barrios, Carlos H., Lluch, Ana, Martín, Miguel, Locci, Mariavittoria, De Placido, Sabino, and Prat, Aleix

Published
2021
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20. Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver

Author

Carotti, Simone, Lettieri-Barbato, Daniele, Piemonte, Fiorella, Ruggiero, Sergio, Rosina, Marco, Zalfa, Francesca, Zingariello, Maria, Arciprete, Francesca, Valentini, Francesco, Francesconi, Maria, D’Amico, Jessica, De Vincentis, Antonio, Baiocchini, Andrea, Perrone, Giuseppe, Antonelli-Incalzi, Raffaele, Morini, Sergio, Picardi, Antonio, Aquilano, Katia, and Vespasiani-Gentilucci, Umberto

Published
2021
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21. PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey

Author

Cerbelli, Bruna, primary, Cirillo, Alessio, additional, Pomati, Giulia, additional, Pernazza, Angelina, additional, Ascione, Andrea, additional, Pisegna, Simona, additional, Pisano, Annalinda, additional, Leopizzi, Martina, additional, Pignataro, Maria Gemma, additional, Costarelli, Leopoldo, additional, Mulè, Antonino, additional, Vecchione, Andrea, additional, Catalano, Piera, additional, Coppola, Luigi, additional, Perrone, Giuseppe, additional, Perracchio, Letizia, additional, Anemona, Lucia, additional, Mastracchio, Antonio, additional, Nardi, Stefano, additional, Reitano, Renato, additional, Massari, Annalisa, additional, Grillo, Lucia Rosalba, additional, Liberati, Fabrizio, additional, Della Rocca, Carlo, additional, Marchetti, Paolo, additional, Botticelli, Andrea, additional, and D’Amati, Giulia, additional

Published
2023
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22. Data from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

Author

Cortellini, Alessio, primary, D'Alessio, Antonio, primary, Cleary, Siobhan, primary, Buti, Sebastiano, primary, Bersanelli, Melissa, primary, Bordi, Paola, primary, Tonini, Giuseppe, primary, Vincenzi, Bruno, primary, Tucci, Marco, primary, Russo, Alessandro, primary, Pantano, Francesco, primary, Russano, Marco, primary, Stucci, Luigia Stefania, primary, Sergi, Maria Chiara, primary, Falconi, Martina, primary, Zarzana, Maria Antonietta, primary, Santini, Daniele, primary, Spagnolo, Francesco, primary, Tanda, Enrica T., primary, Rastelli, Francesca, primary, Giorgi, Francesca Chiara, primary, Pergolesi, Federica, primary, Giusti, Raffaele, primary, Filetti, Marco, primary, Lo Bianco, Francesca, primary, Marchetti, Paolo, primary, Botticelli, Andrea, primary, Gelibter, Alain, primary, Siringo, Marco, primary, Ferrari, Marco, primary, Marconcini, Riccardo, primary, Vitale, Maria Giuseppa, primary, Nicolardi, Linda, primary, Chiari, Rita, primary, Ghidini, Michele, primary, Nigro, Olga, primary, Grossi, Francesco, primary, De Tursi, Michele, primary, Di Marino, Pietro, primary, Queirolo, Paola, primary, Bracarda, Sergio, primary, Macrini, Serena, primary, Inno, Alessandro, primary, Zoratto, Federica, primary, Veltri, Enzo, primary, Spoto, Chiara, primary, Vitale, Maria Grazia, primary, Cannita, Katia, primary, Gennari, Alessandra, primary, Morganstein, Daniel L., primary, Mallardo, Domenico, primary, Nibid, Lorenzo, primary, Sabarese, Giovanna, primary, Brunetti, Leonardo, primary, Perrone, Giuseppe, primary, Ascierto, Paolo A., primary, Ficorella, Corrado, primary, and Pinato, David J., primary

Published
2023
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23. Seismic reliability of Italian code‐conforming bridges

Author

Franchin, Paolo, primary, Baltzopoulos, Georgios, additional, Biondini, Fabio, additional, Callisto, Luigi, additional, Capacci, Luca, additional, Carbonari, Sandro, additional, Cardone, Donatello, additional, Dall'Asta, Andrea, additional, Flora, Amedeo, additional, Gorini, Davide Noè, additional, Marchi, Andrea, additional, Noto, Fabrizio, additional, Perrone, Giuseppe, additional, and Iervolino, Iunio, additional

Published
2023
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24. Response of GAFChromic® HD-V2 film dosimeter in 10-300 Gy dose range for radiation testing of electronic devices

Author

Martorana Francesca, Parlato Aldo, Perrone Giuseppe, and Tomarchio Elio Angelo Giuseppe

Subjects
Gafchromic dosimetry, HD-V2 film, gamma-ray irradiation, dose, electronic device, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The study reported in this paper aimed to investigate the response of a GAFChromic® HD-V2 film dosimeter in the dose range between 10 and 300 Gy, normally used to perform irradiation tests on electronic devices with a 60Co gamma-ray irradiator. The well-defined linearity of response in terms of absorbance as a function of absorbed dose, easiness of handling and data analysis of irradiated dosimeters, reproducibility, stability, and insensitivity to visible light and most of the environmental parameters, make HD-V2 film a flexible, inexpensive and reliable dose measurement device. The study has shown a fogging effect of the dosimeter response since its value changes over time. Strategies and adequate precautions to take into account changes on HD-V2 film physical properties for calibration and routine use in industrial applications, with a specific reference to radiation testing of electronic devices, have been discussed.

Published
2019
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25. Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale

Author

Casadei Gardini, Andrea, Faloppi, Luca, De Matteis, Serena, Foschi, Francesco Giuseppe, Silvestris, Nicola, Tovoli, Francesco, Palmieri, Vincenzo, Marisi, Giorgia, Brunetti, Oronzo, Vespasiani-Gentilucci, Umberto, Perrone, Giuseppe, Valgiusti, Martina, Granato, Anna Maria, Ercolani, Giorgio, Negrini, Giulia, Tamburini, Emiliano, Aprile, Giuseppe, Passardi, Alessandro, Santini, Daniele, Cascinu, Stefano, Frassineti, Giovanni Luca, and Scartozzi, Mario

Published
2017
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27. Supplementary Table S8 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

Author

Cortellini, Alessio, primary, D'Alessio, Antonio, primary, Cleary, Siobhan, primary, Buti, Sebastiano, primary, Bersanelli, Melissa, primary, Bordi, Paola, primary, Tonini, Giuseppe, primary, Vincenzi, Bruno, primary, Tucci, Marco, primary, Russo, Alessandro, primary, Pantano, Francesco, primary, Russano, Marco, primary, Stucci, Luigia Stefania, primary, Sergi, Maria Chiara, primary, Falconi, Martina, primary, Zarzana, Maria Antonietta, primary, Santini, Daniele, primary, Spagnolo, Francesco, primary, Tanda, Enrica T., primary, Rastelli, Francesca, primary, Giorgi, Francesca Chiara, primary, Pergolesi, Federica, primary, Giusti, Raffaele, primary, Filetti, Marco, primary, Lo Bianco, Francesca, primary, Marchetti, Paolo, primary, Botticelli, Andrea, primary, Gelibter, Alain, primary, Siringo, Marco, primary, Ferrari, Marco, primary, Marconcini, Riccardo, primary, Vitale, Maria Giuseppa, primary, Nicolardi, Linda, primary, Chiari, Rita, primary, Ghidini, Michele, primary, Nigro, Olga, primary, Grossi, Francesco, primary, De Tursi, Michele, primary, Di Marino, Pietro, primary, Queirolo, Paola, primary, Bracarda, Sergio, primary, Macrini, Serena, primary, Inno, Alessandro, primary, Zoratto, Federica, primary, Veltri, Enzo, primary, Spoto, Chiara, primary, Vitale, Maria Grazia, primary, Cannita, Katia, primary, Gennari, Alessandra, primary, Morganstein, Daniel L., primary, Mallardo, Domenico, primary, Nibid, Lorenzo, primary, Sabarese, Giovanna, primary, Brunetti, Leonardo, primary, Perrone, Giuseppe, primary, Ascierto, Paolo A., primary, Ficorella, Corrado, primary, and Pinato, David J., primary

Published
2023
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28. Supplementary Figure S8 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

Author

Cortellini, Alessio, primary, D'Alessio, Antonio, primary, Cleary, Siobhan, primary, Buti, Sebastiano, primary, Bersanelli, Melissa, primary, Bordi, Paola, primary, Tonini, Giuseppe, primary, Vincenzi, Bruno, primary, Tucci, Marco, primary, Russo, Alessandro, primary, Pantano, Francesco, primary, Russano, Marco, primary, Stucci, Luigia Stefania, primary, Sergi, Maria Chiara, primary, Falconi, Martina, primary, Zarzana, Maria Antonietta, primary, Santini, Daniele, primary, Spagnolo, Francesco, primary, Tanda, Enrica T., primary, Rastelli, Francesca, primary, Giorgi, Francesca Chiara, primary, Pergolesi, Federica, primary, Giusti, Raffaele, primary, Filetti, Marco, primary, Lo Bianco, Francesca, primary, Marchetti, Paolo, primary, Botticelli, Andrea, primary, Gelibter, Alain, primary, Siringo, Marco, primary, Ferrari, Marco, primary, Marconcini, Riccardo, primary, Vitale, Maria Giuseppa, primary, Nicolardi, Linda, primary, Chiari, Rita, primary, Ghidini, Michele, primary, Nigro, Olga, primary, Grossi, Francesco, primary, De Tursi, Michele, primary, Di Marino, Pietro, primary, Queirolo, Paola, primary, Bracarda, Sergio, primary, Macrini, Serena, primary, Inno, Alessandro, primary, Zoratto, Federica, primary, Veltri, Enzo, primary, Spoto, Chiara, primary, Vitale, Maria Grazia, primary, Cannita, Katia, primary, Gennari, Alessandra, primary, Morganstein, Daniel L., primary, Mallardo, Domenico, primary, Nibid, Lorenzo, primary, Sabarese, Giovanna, primary, Brunetti, Leonardo, primary, Perrone, Giuseppe, primary, Ascierto, Paolo A., primary, Ficorella, Corrado, primary, and Pinato, David J., primary

Published
2023
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30. Type 2 diabetes mellitus and efficacy outcomes from imune checkpoint blockade in patients with cancer

Author

Cortellini, Alessio, primary, D'Alessio, Antonio, additional, Cleary, Siobhan, additional, Buti, Sebastiano, additional, Bersanelli, Melissa, additional, Bordi, Paola, additional, Tonini, Giuseppe, additional, Vincenzi, Bruno, additional, Tucci, Marco, additional, Russo, Alessandro, additional, Pantano, Francesco, additional, Russano, Marco, additional, Stucci, Luigia Stefania, additional, Sergi, Maria Chiara, additional, Falconi, Martina, additional, Zarzana, Maria Antonietta., additional, Santini, Daniele, additional, Spagnolo, Francesco, additional, Tanda, Enrica T., additional, Rastelli, Francesca, additional, Giorgi, Francesca Chiara., additional, Pergolesi, Federica, additional, Giusti, Raffaele, additional, Filetti, Marco, additional, Lo Bianco, Francesca, additional, Marchetti, Paolo, additional, Botticelli, Andrea, additional, Gelibter, Alain, additional, Siringo, Marco, additional, Ferrari, Marco, additional, Marconcini, Riccardo, additional, Vitale, Maria Giuseppa., additional, Nicolardi, Linda, additional, Chiari, Rita, additional, Ghidini, Michele, additional, Nigro, Olga, additional, Grossi, Francesco, additional, De Tursi, Michele, additional, Di Marino, Pietro, additional, Queirolo, Paola, additional, Bracarda, Sergio, additional, Macrini, Serena, additional, Inno, Alessandro, additional, Zoratto, Federica, additional, Veltri, Enzo, additional, Spoto, Chiara, additional, Vitale, Maria Grazia., additional, Cannita, Katia, additional, Gennari, Alessandra, additional, Morganstein, Daniel L., additional, Mallardo, Domenico, additional, Nibid, Lorenzo, additional, Sabarese, Giovanna, additional, Brunetti, Leonardo, additional, Perrone, Giuseppe, additional, Ascierto, Paolo A., additional, Ficorella, Corrado, additional, and Pinato, David J., additional

Published
2023
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31. PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey

Author

Cerbelli, Bruna, Cirillo, Alessio, Pomati, Giulia, Pernazza, Angelina, Ascione, Andrea, Pisegna, Simona, Pisano, Annalinda, Leopizzi, Martina, Pignataro, Maria Gemma, Costarelli, Leopoldo, Mulè, Antonino, Vecchione, Andrea, Catalano, Piera, Coppola, Luigi, Perrone, Giuseppe, Perracchio, Letizia, Anemona, Lucia, Mastracchio, Antonio, Nardi, Stefano, Reitano, Renato, Massari, Annalisa, Grillo, Lucia Rosalba, Liberati, Fabrizio, Della Rocca, Carlo, Marchetti, Paolo, Botticelli, Andrea, and D’Amati, Giulia

Abstract

Background: Immunotherapy has revolutionized the approach to metastatic triple-negative breast cancers. Atezolizumab was approved for patients with metastatic triple-negative breast cancers whose tumors express PD-L1, determined by SP 142 assay. To assess the availability and practice of SP142 test we administered a survey to all the 15 pathology departments of the Lazio Region during a six-month period.Methods: The survey comprised 12 questions regarding the availability of SP142 in the pathology departments, the percentage of positive tests, the difficulties of pathologists in cases close to cut-off value and the tested samples.Results: The SP142 assay was available in only eight centers. In case of positive result, most centers (5/8, 62.5%) reported values of PD-L1 expression ranging from > 1 to ⩽ 5%, with values close to the cut-off point (⩾ 1% or < 1%) being the greatest challenge. Most of the centers (6/8, 75%) tested material from both their own and other hospitals. In most centers, the evaluations were performed either on primary tumors or metastasis, in particular lymph nodes (5/8, 62.5%), followed by lung (3/8, 37.5%) and liver (1/8, 12.5%) metastasis.Conclusion: Our results raise some important issues concerning the evaluation of PD-L1 in the “real-life” setting, providing strategies for its implementation.

Published
2024
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33. Long-Term Sequential Digital Dermoscopy of Low-Risk Patients May Not Improve Early Diagnosis of Melanoma Compared to Periodical Handheld Dermoscopy

Author

Borroni, Riccardo G., primary, Panasiti, Vincenzo, additional, Valenti, Mario, additional, Gargiulo, Luigi, additional, Perrone, Giuseppe, additional, Dall’Alba, Roberta, additional, Fava, Clarissa, additional, Sacrini, Francesco, additional, Mancini, Luca L., additional, Manara, Sofia A. A. M., additional, Morenghi, Emanuela, additional, and Costanzo, Antonio, additional

Published
2023
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36. Subaxillary Replacement Flap Compared with the Round Block Displacement Technique in Oncoplastic Breast Conserving Surgery: Functional Outcomes of a Feasible One Stage Reconstruction

Author

Orsaria, Paolo, primary, Grasso, Antonella, additional, Soponaru, Georgeta, additional, Carnevale, Francesca, additional, Scorsone, Virginia, additional, Ippolito, Edy, additional, Pantano, Francesco, additional, Sammarra, Matteo, additional, Piccolo, Claudia, additional, Altomare, Michele, additional, Perrone, Giuseppe, additional, and Altomare, Vittorio, additional

Published
2022
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39. Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas

Author

Iorio, Jessica, primary, Antonuzzo, Lorenzo, additional, Scarpi, Emanuela, additional, D’Amico, Massimo, additional, Duranti, Claudia, additional, Messerini, Luca, additional, Sparano, Clotilde, additional, Caputo, Damiano, additional, Lavacchi, Daniele, additional, Borzomati, Domenico, additional, Antonelli, Alice, additional, Nibid, Lorenzo, additional, Perrone, Giuseppe, additional, Coppola, Alessandro, additional, Coppola, Roberto, additional, di Costanzo, Francesco, additional, Lastraioli, Elena, additional, and Arcangeli, Annarosa, additional

Published
2022
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40. Uncommon EGFR mutations in non-small-cell lung cancer

Author

Russano, Marco, primary, Perrone, Giuseppe, additional, Di Fazio, Giuseppina Rita, additional, Galletti, Alessandro, additional, Citarella, Fabrizio, additional, Santo, Valentina, additional, Brunetti, Leonardo, additional, Vendittelli, Alessia, additional, Vincenzi, Bruno, additional, Tonini, Giuseppe, additional, and Santini, Daniele, additional

Published
2022
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43. Large-Scale Profiling of Extracellular Vesicles Identified miR-625-5p as a Novel Biomarker of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer Patients

Author

Pantano, Francesco, primary, Zalfa, Francesca, additional, Iuliani, Michele, additional, Simonetti, Sonia, additional, Manca, Paolo, additional, Napolitano, Andrea, additional, Tiberi, Simone, additional, Russano, Marco, additional, Citarella, Fabrizio, additional, Foderaro, Simone, additional, Vulpis, Elisabetta, additional, Zingoni, Alessandra, additional, Masuelli, Laura, additional, Bei, Roberto, additional, Ribelli, Giulia, additional, Del Re, Marzia, additional, Danesi, Romano, additional, Vincenzi, Bruno, additional, Perrone, Giuseppe, additional, Tonini, Giuseppe, additional, and Santini, Daniele, additional

Published
2022
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46. PD-L1 Testing In Metastatic Triple Negative Breast Cancer: Results Of An Italian Survey

Author

Cerbelli, Bruna, primary, Cirillo, Alessio, additional, Pomati, Giulia, additional, Pernazza, Angelina, additional, Ascione, Andrea, additional, Pisegna, Simona, additional, Pisano, Annalinda, additional, Leopizzi, Martina, additional, Pignataro, Maria Gemma, additional, Costarelli, Leopoldo, additional, Mulè, Antonino, additional, Vecchione, Andrea, additional, Catalano, Piera, additional, Coppola, Luigi, additional, Perrone, Giuseppe, additional, Perracchio, Letizia, additional, Anemona, Lucia, additional, Mastracchio, Antonio, additional, Nardi, Stefano, additional, Reitano, Renato, additional, Massari, Annalisa, additional, Grillo, Lucia Rosalba, additional, Liberati, Fabrizio, additional, Rocca, Carlo Della, additional, Marchetti, Paolo, additional, Botticelli, Andrea, additional, and D’Amati, Giulia, additional

Published
2022
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47. Preoperative Ultrasound-guided Sub-areolar Biopsy in Predicting Occult Nipple Involvement in Breast Cancer Patients: Proposal for a Methodological Approach

Author

ALTOMARE, VITTORIO, primary, ORSARIA, PAOLO, additional, GRASSO, ANTONELLA, additional, CAGGIATI, LORENZA, additional, IPPOLITO, EDY, additional, PANTANO, FRANCESCO, additional, SAMMARRA, MATTEO, additional, ALTOMARE, CARLO, additional, PERRONE, GIUSEPPE, additional, GULLOTTA, GABRIELLA, additional, and CARINO, RITA, additional

Published
2022
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48. Accuracy of controlled attenuation parameter for assessing liver steatosis in individuals with morbid obesity before bariatric surgery

Author

Tavaglione, Federica, primary, De Vincentis, Antonio, additional, Bruni, Vincenzo, additional, Gallo, Ida Francesca, additional, Carotti, Simone, additional, Tuccinardi, Dario, additional, Spagnolo, Giuseppe, additional, Ciociola, Ester, additional, Mancina, Rosellina Margherita, additional, Jamialahmadi, Oveis, additional, D’Alessio, Rossella, additional, Bottazzi, Bruna, additional, Manfrini, Silvia, additional, Picardi, Antonio, additional, Perrone, Giuseppe, additional, Pozzilli, Paolo, additional, Caricato, Marco, additional, Vespasiani‐Gentilucci, Umberto, additional, and Romeo, Stefano, additional

Published
2021
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49. Role and evaluation of pathologic response in early breast cancer specimens after neoadjuvant therapy: consensus statement

Author

Guerini-Rocco, Elena, primary, Botti, Gerardo, additional, Foschini, Maria Pia, additional, Marchiò, Caterina, additional, Mastropasqua, Mauro Giuseppe, additional, Perrone, Giuseppe, additional, Roz, Elena, additional, Santinelli, Alfredo, additional, Sassi, Isabella, additional, Galimberti, Viviana, additional, Gianni, Luca, additional, and Viale, Giuseppe, additional

Published
2021
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50. Evaluating programmed death‐ligand 1 (PD‐L1) in head and neck squamous cell carcinoma: concordance between the 22C3 PharmDx assay and the SP263 assay on whole sections from a multicentre study

Author

Cerbelli, Bruna, primary, Girolami, Ilaria, additional, Eccher, Albino, additional, Costarelli, Leopoldo, additional, Taccogna, Silvia, additional, Scialpi, Renzo, additional, Benevolo, Maria, additional, Lucante, Teresa, additional, Luigi Alò, Piero, additional, Stella, Francesca, additional, Gemma Pignataro, Maria, additional, Fadda, Guido, additional, Perrone, Giuseppe, additional, D’Amati, Giulia, additional, and Martini, Maurizio, additional

Published
2021
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