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3. Optical Spectroscopy for on Line Water Monitoring

Author

Testa, Genni, Persichetti, Gianluca, Bernini, Romeo, Kostianoy, Andrey, Series Editor, Carpenter, Angela, Editorial Board Member, Younos, Tamim, Editorial Board Member, Scozzari, Andrea, Editorial Board Member, Vignudelli, Stefano, Editorial Board Member, Kouraev, Alexei, Editorial Board Member, Di Mauro, Anna, editor, and Soldovieri, Francesco, editor

Published
2022
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4. An integrated device for fast and sensitive immunosuppressant detection

Author

Tombelli, Sara, Trono, Cosimo, Berneschi, Simone, Berrettoni, Chiara, Giannetti, Ambra, Bernini, Romeo, Persichetti, Gianluca, Testa, Genni, Orellana, Guillermo, Salis, Francesca, Weber, Susanne, Luppa, Peter B., Porro, Giampiero, Quarto, Giovanna, Schubert, Markus, Berner, Marcel, Freitas, Paulo P., Cardoso, Susana, Franco, Fernando, Silverio, Vânia, Lopez-Martinez, Maria, Hilbig, Urs, Freudenberger, Kathrin, Gauglitz, Günter, Becker, Holger, Gärtner, Claudia, O’Connell, Mark T., and Baldini, Francesco

Published
2022
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5. Portable Fluorescence Sensor for Organic Contaminants and Cyanobacterial Detection in Waters

Author

Persichetti, Gianluca, Combot, Doriane, Pelissier, Pablo, Savio, Saverio, Testa, Genni, Congestri, Roberta, Labbe, Laurent, Bernini, Romeo, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Di Francia, Girolamo, editor, and Di Natale, Corrado, editor

Published
2021
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6. UV Autofluorescence Spectroscopy for Cyanobacteria Monitoring and Discrimination in Source Water

Author

Persichetti, Gianluca, Testa, Genni, Bernini, Romeo, Viaggiu, Emanuela, Congestri, Roberta, Dumas, Victor, Labbe, Laurent, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Di Francia, G., editor, Di Natale, C., editor, Alfano, B., editor, De Vito, S., editor, Esposito, E., editor, Fattoruso, G., editor, Formisano, F., editor, Massera, E., editor, Miglietta, M. L., editor, and Polichetti, T., editor

Published
2020
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8. Real Time Flow-Through Biosensor

Author

Grimaldi, Immacolata Angelica, Testa, Genni, Persichetti, Gianluca, Bernini, Romeo, Andò, Bruno, editor, Baldini, Francesco, editor, Di Natale, Corrado, editor, Marrazza, Giovanna, editor, and Siciliano, Pietro, editor

Published
2018
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9. Microfluidic Optical Methods: A Review

Author

Testa, Genni, Persichetti, Gianluca, Bernini, Romeo, Barceló, Damià, Editor-in-chief, Kostianoy, Andrey G., Editor-in-chief, Scozzari, Andrea, editor, and Dotsika, Elissavet, editor

Published
2016
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20. Combining micro-optics and integrated optics: a case study on bulk resonators

Author

Farnesi, Daniele, primary, Frigenti, Gabriele, additional, Pelli, Stefano, additional, Soria, Silvia, additional, Berneschi, Simone, additional, Baldini, Francesco, additional, Testa, Genni, additional, Persichetti, Gianluca, additional, Bernini, Romeo, additional, Cheben, Pavel, additional, Vivien, Laurent, additional, Le Rouxe, Xavier, additional, Alonso-Ramos, Carlos, additional, and Nunzi Conti, Gualtiero, additional

Published
2022
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23. An integrated device for fast and sensitive immunosuppressant detection

Author

Tombelli, Sara, primary, Trono, Cosimo, additional, Berneschi, Simone, additional, Berrettoni, Chiara, additional, Giannetti, Ambra, additional, Bernini, Romeo, additional, Persichetti, Gianluca, additional, Testa, Genni, additional, Orellana, Guillermo, additional, Salis, Francesca, additional, Weber, Susanne, additional, Luppa, Peter B., additional, Porro, Giampiero, additional, Quarto, Giovanna, additional, Schubert, Markus, additional, Berner, Marcel, additional, Freitas, Paulo P., additional, Cardoso, Susana, additional, Franco, Fernando, additional, Silverio, Vânia, additional, Lopez-Martinez, Maria, additional, Hilbig, Urs, additional, Freudenberger, Kathrin, additional, Gauglitz, Günter, additional, Becker, Holger, additional, Gärtner, Claudia, additional, O’Connell, Mark T., additional, and Baldini, Francesco, additional

Published
2021
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25. An integrated device for fast and sensitive immunosuppressant detection

Author

Tombelli, Sara, Trono, Cosimo, Berneschi, Simone, Berrettoni, Chiara, Giannetti, Ambra, Bernini, Romeo, Persichetti, Gianluca, Testa, Genni, Orellana, Guillermo, Salis, Francesca, Weber, Susanne, Luppa, Peter B., Porro, Giampiero, Quarto, Giovanna, Schubert, Markus, Berner, Marcel, Freitas, Paulo P., Cardoso, Susana, Franco, Fernando, Silverio, Vania, Lopez-Martinez, Maria, Hilbig, Urs, Freudenberger, Kathrin, Gauglitz, Gunter, Becker, Holger, Gartner, Claudia, O'Connell, Mark T., and Baldini, Francesco

Subjects
Cyclosporine A, Mycophenolic acid, POCT, Fluorescence, Immunosuppressant
Abstract

The present paper describes a compact point of care (POC) optical device for therapeutic drug monitoring (TDM). The core of the device is a disposable plastic chip where an immunoassay for the determination of immunosuppressants takes place. The chip is designed in order to have ten parallel microchannels allowing the simultaneous detection of more than one analyte with replicate measurements. The device is equipped with a microfluidic system, which provides sample mixing with the necessary chemicals and pumping samples, reagents and buffers into the measurement chip, and with integrated thin film amorphous silicon photodiodes for the fluorescence detection. Submicrometric fluorescent magnetic particles are used as support in the immunoassay in order to improve the efficiency of the assay. In particular, the magnetic feature is used to concentrate the antibody onto the sensing layer leading to a much faster implementation of the assay, while the fluorescent feature is used to increase the optical signal leading to a larger optical dynamic change and consequently a better sensitivity and a lower limit of detection. The design and development of the whole integrated optical device are here illustrated. In addition, detection of mycophenolic acid and cyclosporine A in spiked solutions and in microdialysate samples from patient blood with the implemented device are reported.

Published
2021
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33. Waveguide-based coupling of coated micro-spherical resonators

Author

Nunzi Conti, Gualtiero, primary, Barucci, Andrea, additional, Grimaldi, Immacolata A., additional, Persichetti, Gianluca, additional, Berneschi, Simone, additional, Soria, Silvia, additional, Tiribilli, Bruno, additional, Bernini, Romeo, additional, and Baldini, Francesco, additional

Published
2019
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36. Glass-based microresonators

Author

Nunzi Conti, Gualtiero, primary, Berneschi, Simone, primary, Farnesi, Daniele, primary, Frigenti, Gabriele, primary, Righini, Giancarlo C., primary, Pelli, Stefano, primary, Soria, Silvia, primary, Baldini, Francesco, primary, Dumeige, Yannick, primary, Féron, Patrice, primary, Ristić, Davor, primary, Ivanda, Mile, primary, Prudenzano, Francesco, primary, Bernini, Romeo, primary, Cosi, Franco, primary, and Persichetti, Gianluca, primary

Published
2018
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40. A POCT platform for sepsis biomarkers (Conference Presentation)

Author

Baldini, Francesco, primary, Adinolfi, Barbara, additional, Berneschi, Simone, additional, Bernini, Romeo, additional, Giannetti, Ambra, additional, Grimaldi, Immacolata Angelica, additional, Persichetti, Gianluca, additional, Testa, Genni, additional, Tombelli, Sara, additional, and Trono, Cosimo, additional

Published
2017
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42. Novel fluorescence-based POCT platform for therapeutic drug monitoring in transplanted patients (Conference Presentation)

Author

Baldini, Francesco, primary, Berrettoni, Chiara, additional, Giannetti, Ambra, additional, Tombelli, Sara, additional, Trono, Cosimo, additional, Porro, Giampiero, additional, Bernini, Romeo, additional, Grimaldi, Immacolata Angelica, additional, Testa, Genni, additional, Persichetti, Gianluca, additional, Gärtner, Claudia, additional, Becker, Holger, additional, Berner, Marcel, additional, Schubert, Markus B., additional, O'Connell, Mark T., additional, Carney, Daniel, additional, Orellana, Guillermo, additional, Descalzo, Ana B., additional, Salis, Francesca, additional, Freitas, Paulo P., additional, Luppa, Peter B., additional, Bittersohl, Heike, additional, Gauglitz, Günter, additional, Hilbig, Urs, additional, and Freudenberger, Kathrin, additional

Published
2017
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44. Water-jet waveguide for fluorescence spectroscopy

Author

Persichetti, Gianluca, Testa, Genni, and Bernini, Romeo

Subjects
Physics::Optics
Abstract

An optofluidic sensor based on a liquid-jet waveguide is presented. The waveguide consists of a high-speed water jet produced by means of a microchannel coupled with a multimode optical fibre collecting the fluorescence opportunely excited. The liquid jet acts, at the same time, as the solution to analyse and as an optical waveguide. This configuration allows a strong reduction of the scattering and fluorescence of non-analyte substances enabling a very low limit of detection (LOD). The integrated device is fabricated by PMMA micro-machining allowing a self-alignment between the liquid-jet waveguide and the optical fibre used to deliver the fluorescence to the detector. The performance of the system has been tested on Cy5 water solutions and LOD of 2.56 nM has been obtained. A proof-of-concept of filter-free measurements has been performed demonstrating that fluorescence measurements can be performed also by using a photodiode with an LOD of 6.11 nM. © 2014 Springer International Publishing Switzerland.

Published
2014

45. Polymer microflow cytofluorometer

Author

Testa, Genni, Persichetti, Gianluca, and Bernini, Romeo

Abstract

This paper reports a microflow cytometer fabricated in polymethylmethacrylate (PMMA) in which a 3D hydrodynamic flow focusing is employed in order to align the particles in a single line along the focused stream. By exploiting an innovative and simple technique to realize a 3D hydrodynamic focusing effect, a tunable and circular-shaped focused stream has been obtained. The device has been fabricated by direct micromilling of two parts of PMMA that were finally bonded together. Flow cytometry measurements have been performed by using 10 ?m-sized fluorescent particles. From the analysis of the fluorescence signals collected at each transit event, we can confirm that the device is capable of creating a single-file particle stream. © 2014 Springer International Publishing Switzerland.

Published
2014

50. Total Internal Reflection Fluorescence-based Optical Biochip for the Detection of Immunosuppressants in Transplanted Patients

Author

Adinolfi, Barbara, primary, Baldini, Francesco, additional, Berrettoni, Chiara, additional, Berneschi, Simone, additional, Giannetti, Ambra, additional, Tombelli, Sara, additional, Trono, Cosimo, additional, Bernini, Romeo, additional, Grimaldi, Immacolata A., additional, Persichetti, Gianluca, additional, Testa, Genni, additional, Kremer, Clemens, additional, and Gartner, Claudia, additional

Published
2015
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